Advances in Experimental Medicine and Biology 
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This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.Necroptosis and Its Involvement in Various Diseases
Adv Exp Med Biol. 2024;1444:129-143. doi: 10.1007/978-981-99-9781-7_9.ABSTRACTNecroptosis is a regulated form of cell death involved in the development of various pathological conditions. In contrast to apoptosis, plasma membrane rupture (PMR) occurs in cells in the relatively early stage of necroptosis; therefore, necroptosis induces a strong inflammatory response. Stimuli, including tumor necrosis factor (TNF), interferon (IFN)α/β, lipopolysaccharide, polyI:C, and viral infection, induce the formation of necrosomes that lead to membrane rupture and the release of intracellular contents, termed danger-associated molecul...
Source: Advances in Experimental Medicine and Biology - March 12, 2024 Category: Research Authors: Hiroyasu Nakano Source Type: research
RNA Metabolism Governs Immune Function and Response
Adv Exp Med Biol. 2024;1444:145-161. doi: 10.1007/978-981-99-9781-7_10.ABSTRACTInflammation is a complex process that protects our body from various insults such as infection, injury, and stress. Proper inflammation is beneficial to eliminate the insults and maintain organ homeostasis, however, it can become detrimental if uncontrolled. To tightly regulate inflammation, post-transcriptional mechanisms governing RNA metabolism play a crucial role in monitoring the expression of immune-related genes, such as tumor necrosis factor (TNF) and interleukin-6 (IL-6). These mechanisms involve the coordinated action of various RNA-b...
Source: Advances in Experimental Medicine and Biology - March 12, 2024 Category: Research Authors: Masanori Yoshinaga Osamu Takeuchi Source Type: research
Development of Orally Ingestible IgA Antibody Drugs to Maintain Symbiosis Between Humans and Microorganisms
Adv Exp Med Biol. 2024;1444:165-176. doi: 10.1007/978-981-99-9781-7_11.ABSTRACTIn recent years, dysbiosis, abnormalities in the gut microbiota, has been reported to be associated with the development of many diseases, and improving the gut microbiota is important for health maintenance. It has been shown that the host recognizes and regulates intestinal bacteria by means of IgA antibodies secreted into the gut, but the precise nature of the commensal gut bacteria recognized by each IgA antibody is unclear. We have cloned monoclonal IgA antibodies from mouse intestinal IgA-producing cells and are searching for bacterial mol...
Source: Advances in Experimental Medicine and Biology - March 12, 2024 Category: Research Authors: Reiko Shinkura Source Type: research
TCR Signals Controlling Adaptive Immunity against Toxoplasma and Cancer
Adv Exp Med Biol. 2024;1444:177-193. doi: 10.1007/978-981-99-9781-7_12.ABSTRACTT cells play a crucial role in adaptive immunity by recognizing and eliminating foreign pathogens and abnormal cells such as cancer cells. T cell receptor (TCR), which is expressed on the surface of T cells, recognizes and binds to specific antigens presented by major histocompatibility complex (MHC) molecules on antigen-presenting cells (APCs). This activation process leads to the proliferation and differentiation of T cells, allowing them to carry out their specific immune response functions. This chapter outlines the TCR signaling pathways th...
Source: Advances in Experimental Medicine and Biology - March 12, 2024 Category: Research Authors: Masaaki Okamoto Masahiro Yamamoto Source Type: research
Molecular Imaging of PD-1 Unveils Unknown Characteristics of PD-1 Itself by Visualizing "PD-1 Microclusters"
Adv Exp Med Biol. 2024;1444:197-205. doi: 10.1007/978-981-99-9781-7_13.ABSTRACTProgrammed cell death-1 (PD-1) is one of the most famous coinhibitory receptors that are expressed on effector T cells to regulate their function. The PD-1 ligands, PD-L1 and PD-L2, are expressed by various cells throughout the body at steady state and their expression was further regulated within different pathological conditions such as tumor-bearing and chronic inflammatory diseases. In recent years, immune checkpoint inhibitor (ICI) therapies with anti-PD-1 or anti-PD-L1 has become a standard treatment for various malignancies and has shown ...
Source: Advances in Experimental Medicine and Biology - March 12, 2024 Category: Research Authors: Wataru Nishi Ei Wakamatsu Hiroaki Machiyama Ryohei Matsushima Yosuke Yoshida Tetsushi Nishikawa Hiroko Toyota Masae Furuhata Hitoshi Nishijima Arata Takeuchi Makoto Suzuki Tadashi Yokosuka Source Type: research
