Detection of two synchronous histologically different renal cell carcinoma subtypes in the same kidney: a case report and review of the literature
ConclusionThe coexistence of dissimilar RCC subtypes can contribute to diverse prognostic implications. Further research should focus on enhancing the complex, yet highly crucial, preoperative detection and pathological examination to differentiate multiple renal lesions. Planning optimal operative techniques (radical or partial nephrectomy), selecting suitable adjuvant regimens, and reporting long-term follow-up outcomes of patients in whom synchronous yet different RCC subtypes were detected are of utmost importance. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - May 18, 2024 Category: General Medicine Source Type: research
Basal cell carcinoma has greater subclinical extension than squamous cell carcinoma: a cohort study
(Source: Archives of Dermatological Research)
Source: Archives of Dermatological Research - May 18, 2024 Category: Dermatology Source Type: research
Cancers, Vol. 16, Pages 1929: Efficacy of Cytoreductive Surgery (CRS) + HIPEC in Gastric Cancer with Peritoneal Metastasis: Systematic Review and Meta-Analysis
Conclusions: CRS + HIPEC could provide survival advantages in gastric cancer peritoneal metastasis compared to pSC. (Source: Cancers)
Source: Cancers - May 18, 2024 Category: Cancer & Oncology Authors: Lodovica Langellotti Claudio Fiorillo Giorgio D ’Annibale Edoardo Panza Fabio Pacelli Sergio Alfieri Andrea Di Giorgio Francesco Santullo Tags: Systematic Review Source Type: research
Cancers, Vol. 16, Pages 1925: Conventional versus Hepatic Arteriography and C-Arm CT-Guided Ablation of Liver Tumors (HepACAGA): A Comparative Analysis
Conclusions: In this study, the HepACAGA technique was safer and more effective than conventional ablation for HCC and CRLM, resulting in lower rates of local tumor recurrence, longer local tumor recurrence-free survival and fewer procedure-related complications. (Source: Cancers)
Source: Cancers - May 18, 2024 Category: Cancer & Oncology Authors: Niek Wijnen Rutger C. G. Bruijnen Evert-Jan P. A. Vonken Hugo W. A. M. de Jong Joep de Bruijne Guus M. Bol Jeroen Hagendoorn Martijn P. W. Intven Maarten L. J. Smits Tags: Article Source Type: research
Cancers, Vol. 16, Pages 1926: Update on Renal Cell Carcinoma Diagnosis with Novel Imaging Approaches
ier Meyrignac
This review highlights recent advances in renal cell carcinoma (RCC) imaging. It begins with dual-energy computed tomography (DECT), which has demonstrated a high diagnostic accuracy in the evaluation of renal masses. Several studies have suggested the potential benefits of iodine quantification, particularly for distinguishing low-attenuation, true enhancing solid masses from hyperdense cysts. By determining whether or not a renal mass is present, DECT could avoid the need for additional imaging studies, thereby reducing healthcare costs. DECT can also provide virtual unenhanced images, helping to reduce...
Source: Cancers - May 18, 2024 Category: Cancer & Oncology Authors: Marie-France Bellin Catarina Valente Omar Bekdache Florian Maxwell Cristina Balasa Alexia Savignac Olivier Meyrignac Tags: Review Source Type: research
Cancers, Vol. 16, Pages 1931: The Utility of Intraluminal Therapies in Upper Tract Urothelial Carcinoma: A Narrative Review
engupta
Nephron sparing surgery (NSS) is considered for selected cases of upper tract urothelial carcinoma (UTUC) as it maintains renal function and avoids morbidity associated with radical nephroureterectomy (RNU). The appropriate selection of patients suitable for NSS without compromising oncological outcomes can sometimes be difficult, given the limitations of diagnostic modalities. Recurrence rates for UTUC can be as high as 36 to 54% after NSS. Intraluminal adjuvant therapy can be attempted following NSS to reduce recurrence, but delivery to the upper tract is more challenging than into the bladder. Bacillus Calme...
Source: Cancers - May 18, 2024 Category: Cancer & Oncology Authors: Jack Tyrrell William Chui Joshua Kealey Shomik Sengupta Tags: Review Source Type: research
HLA-A+ tertiary lymphoid structures with reactivated tumor infiltrating lymphocytes are associated with a positive immunotherapy response in esophageal squamous cell carcinoma
British Journal of Cancer, Published online: 18 May 2024; doi:10.1038/s41416-024-02712-9HLA-A+ tertiary lymphoid structures with reactivated tumor infiltrating lymphocytes are associated with a positive immunotherapy response in esophageal squamous cell carcinoma (Source: British Journal of Cancer)
Source: British Journal of Cancer - May 18, 2024 Category: Cancer & Oncology Authors: Dandan Zhang Dongxian Jiang Liping Jiang Jiakang Ma Xiaobing Wang Xingyu Xu Ziqiang Chen Mengping Jiang Wenjing Ye Jie Wang Weida Meng Wenqing Qiu Yingyong Hou Jing Huang Yuchen Jiao Yun Liu Zhihua Liu Source Type: research
Cancers, Vol. 16, Pages 1920: Clinical and Genomic Features of Patients with Renal Cell Carcinoma and Advanced Chronic Kidney Disease: Analysis of a Multi-Institutional Database
Conclusions: Using the clinicogenomic ORIEN database, our study found lower rates of BAP1 mutations in RCC specimens from patients with ACKD, which may reflect a BAP1-independent mutational driver of RCC in patients with ACKD. (Source: Cancers)
Source: Cancers - May 18, 2024 Category: Cancer & Oncology Authors: Corbin J. Eule Junxiao Hu Dale Hedges Alkesh Jani Thomas Pshak Brandon J. Manley Alejandro Sanchez Robert Dreicer Zin W. Myint Yousef Zakharia Elaine T. Lam Tags: Article Source Type: research
LARS1 is a Prognostic Biomarker and Exhibits a Correlation with Immune Infiltrates in Hepatocellular Carcinoma
(Source: International Journal of General Medicine)
Source: International Journal of General Medicine - May 17, 2024 Category: General Medicine Tags: International Journal of General Medicine Source Type: research
Meta-analysis of the GALAD model for diagnosing primary hepatocellular carcinoma
CONCLUSION: This meta-analysis confirmed that the GALAD model has excellent diagnostic performance for early-stage and all-stage HCC and can maintain high sensitivity and specificity in early-stage HCC. Therefore, the GALAD model is qualified for screening early-stage canceration from chronic liver disease.PMID:38759033 | DOI:10.3233/THC-231470 (Source: Technology and Health Care)
Source: Technology and Health Care - May 17, 2024 Category: Medical Devices Authors: Jian-Lin Lu Xiao-Yan Yuan Jin-Shan Zhang Yuan Li Source Type: research
Bevacizumab induces ferroptosis and enhances CD8 < sup > + < /sup > T cell immune activity in liver cancer via modulating HAT1 and increasing IL-9
This study provides new insight into the mechanisms by which bevacizumab synergistically modulates ferroptosis and CD8+ T cell immune activity in liver cancer.PMID:38760543 | DOI:10.1038/s41401-024-01299-4 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - May 17, 2024 Category: Drugs & Pharmacology Authors: Chun-Yu Hou Pan Lv Hong-Feng Yuan Li-Na Zhao Yu-Fei Wang Hui-Hui Zhang Guang Yang Xiao-Dong Zhang Source Type: research
Incidence, mortality and survival in people with Merkel cell carcinoma: a systematic review
Br J Dermatol. 2024 May 17;190(6):e64. doi: 10.1093/bjd/ljae159.NO ABSTRACTPMID:38758058 | DOI:10.1093/bjd/ljae159 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 17, 2024 Category: Dermatology Source Type: research
Isobutyric acid enhances the anti-tumour effect of anti-PD-1 antibody
Sci Rep. 2024 May 17;14(1):11325. doi: 10.1038/s41598-024-59677-1.ABSTRACTThe low response rate of immune checkpoint inhibitors (ICIs) is a challenge. The efficacy of ICIs is influenced by the tumour microenvironment, which is controlled by the gut microbiota. In particular, intestinal bacteria and their metabolites, such as short chain fatty acids (SCFAs), are important regulators of cancer immunity; however, our knowledge on the effects of individual SCFAs remains limited. Here, we show that isobutyric acid has the strongest effect among SCFAs on both immune activity and tumour growth. In vitro, cancer cell numbers were ...
Source: Cancer Control - May 17, 2024 Category: Cancer & Oncology Authors: Masakazu Murayama Masahiro Hosonuma Atsuo Kuramasu Sei Kobayashi Akiko Sasaki Yuta Baba Yoichiro Narikawa Hitoshi Toyoda Junya Isobe Eiji Funayama Kohei Tajima Aya Sasaki Yuki Maruyama Yoshitaka Yamazaki Midori Shida Kazuyuki Hamada Yuya Hirasawa Toshiaki Source Type: research
Transarterial Chemoembolization (TACE) Combined with Lenvatinib versus TACE Alone in Intermediate-Stage Hepatocellular Carcinoma Patients Beyond Up-To-Seven Criteria: A Retrospective, Propensity Score-Matched Analysis
CONCLUSION: The combination of TACE and lenvatinib provides clinical benefits for patients with intermediate HCC beyond the up-to-seven criteria, has an acceptable safety profile, shows a trend towards improving liver function, and does not increase the occurrence of grade 3-4 AEs.KEY POINTS: The efficacy of transarterial chemoembolization in intermediate-stage hepatocellular carcinoma patients is partially unsatisfactory. Addition of lenvatinib to transarterial chemoembolization improves OS, PFS, ORR, and DCR for patients with intermediate-stage hepatocellular carcinoma beyond the up-to-seven criteria. This combination th...
Source: Cancer Control - May 17, 2024 Category: Cancer & Oncology Authors: Churen Zhou Boyang Chang Zhanwang Xiang Zhengran Li Chun Wu Mingjun Bai Zaibo Jiang Mingsheng Huang Junwei Chen Source Type: research
Investigating the molecular mechanisms of microRNA ‑409‑3p in tumor progression: Towards targeted therapeutics (Review)
Int J Oncol. 2024 Jul;65(1):67. doi: 10.3892/ijo.2024.5655. Epub 2024 May 17.ABSTRACTMicroRNAs (miRNAs) are a group of non‑coding RNAs that exert master regulatory functions in post‑-transcriptional gene expression. Accumulating evidence shows that miRNAs can either promote or suppress tumorigenesis by regulating different target genes or pathways and may be involved in the occurrence of carcinoma. miR‑409‑3p is dysregulated in a variety of malignant cancers. It plays a fundamental role in numerous cellular biological processes, such as cell proliferation, apoptosis, migration, invasion, autophagy, angiogenesis and...
Source: International Journal of Oncology - May 17, 2024 Category: Cancer & Oncology Authors: Wenjie Xie Zhichao Wang Junke Wang Xiu Wang Hongzai Guan Source Type: research
