The diverse role of the raphe 5-HTergic systems in epilepsy
Acta Pharmacologica Sinica, Published online: 25 May 2022; doi:10.1038/s41401-022-00918-2The diverse role of the raphe 5-HTergic systems in epilepsy (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - May 25, 2022 Category: Drugs & Pharmacology Authors: He-ming Cheng Chen-shu Gao Qiu-wen Lou Zhong Chen Yi Wang Source Type: research

Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis
In this study we investigated the role of APOC1 in GBM tumorigenesis. Using in silico assays we showed that APOC1 was highly expressed in GBM tissues and its expression was closely related to GBM progression. We showed that APOC1 protein expression was markedly increased in four GBM cell lines (U251, U138, A172 and U87) compared to the normal brain glia cell lines (HEB, HA1800). In U251 cells, overexpression of APOC1 promoted cell proliferation, migration, invasion and colony information, which was reversed by APOC1 knockdown. APOC1 knockdown also markedly inhibited the growth of GBM xenografts in the ventricle of nude mic...
Source: Acta Pharmacologica Sinica - May 17, 2022 Category: Drugs & Pharmacology Authors: Xiang-Jin Zheng Wen-Lin Chen Jie Yi Wan Li Jin-Yi Liu Wei-Qi Fu Li-Wen Ren Sha Li Bin-Bin Ge Yi-Hui Yang Yi-Zhi Zhang Hong Yang Guan-Hua Du Yu Wang Jin-Hua Wang Source Type: research

Antagonism of histamine H < sub > 3 < /sub > receptor promotes angiogenesis following focal cerebral ischemia
In conclusion, this study demonstrates that H3R antagonism promotes angiogenesis after cerebral ischemia, which is independent of activation of histaminergic neurons, but related to the H3R on vascular endothelial cells and its interaction with Annexin A2. Thus, H3R antagonists might be promising drug candidates to improve angiogenesis and neurological recovery after ischemic stroke.PMID:35581293 | DOI:10.1038/s41401-022-00916-4 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - May 17, 2022 Category: Drugs & Pharmacology Authors: Li-Shi Fan You-Chao Chen Ru-Jia Liao Yan-Yan Zhao Xiang-Nan Zhang Zhong Chen Lei Jiang Wei-Wei Hu Source Type: research

Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis
In this study we investigated the role of APOC1 in GBM tumorigenesis. Using in silico assays we showed that APOC1 was highly expressed in GBM tissues and its expression was closely related to GBM progression. We showed that APOC1 protein expression was markedly increased in four GBM cell lines (U251, U138, A172 and U87) compared to the normal brain glia cell lines (HEB, HA1800). In U251 cells, overexpression of APOC1 promoted cell proliferation, migration, invasion and colony information, which was reversed by APOC1 knockdown. APOC1 knockdown also markedly inhibited the growth of GBM xenografts in the ventricle of nude mic...
Source: Acta Pharmacologica Sinica - May 17, 2022 Category: Drugs & Pharmacology Authors: Xiang-Jin Zheng Wen-Lin Chen Jie Yi Wan Li Jin-Yi Liu Wei-Qi Fu Li-Wen Ren Sha Li Bin-Bin Ge Yi-Hui Yang Yi-Zhi Zhang Hong Yang Guan-Hua Du Yu Wang Jin-Hua Wang Source Type: research

Antagonism of histamine H < sub > 3 < /sub > receptor promotes angiogenesis following focal cerebral ischemia
In conclusion, this study demonstrates that H3R antagonism promotes angiogenesis after cerebral ischemia, which is independent of activation of histaminergic neurons, but related to the H3R on vascular endothelial cells and its interaction with Annexin A2. Thus, H3R antagonists might be promising drug candidates to improve angiogenesis and neurological recovery after ischemic stroke.PMID:35581293 | DOI:10.1038/s41401-022-00916-4 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - May 17, 2022 Category: Drugs & Pharmacology Authors: Li-Shi Fan You-Chao Chen Ru-Jia Liao Yan-Yan Zhao Xiang-Nan Zhang Zhong Chen Lei Jiang Wei-Wei Hu Source Type: research

Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis
In this study we investigated the role of APOC1 in GBM tumorigenesis. Using in silico assays we showed that APOC1 was highly expressed in GBM tissues and its expression was closely related to GBM progression. We showed that APOC1 protein expression was markedly increased in four GBM cell lines (U251, U138, A172 and U87) compared to the normal brain glia cell lines (HEB, HA1800). In U251 cells, overexpression of APOC1 promoted cell proliferation, migration, invasion and colony information, which was reversed by APOC1 knockdown. APOC1 knockdown also markedly inhibited the growth of GBM xenografts in the ventricle of nude mic...
Source: Acta Pharmacologica Sinica - May 17, 2022 Category: Drugs & Pharmacology Authors: Xiang-Jin Zheng Wen-Lin Chen Jie Yi Wan Li Jin-Yi Liu Wei-Qi Fu Li-Wen Ren Sha Li Bin-Bin Ge Yi-Hui Yang Yi-Zhi Zhang Hong Yang Guan-Hua Du Yu Wang Jin-Hua Wang Source Type: research

Antagonism of histamine H < sub > 3 < /sub > receptor promotes angiogenesis following focal cerebral ischemia
In conclusion, this study demonstrates that H3R antagonism promotes angiogenesis after cerebral ischemia, which is independent of activation of histaminergic neurons, but related to the H3R on vascular endothelial cells and its interaction with Annexin A2. Thus, H3R antagonists might be promising drug candidates to improve angiogenesis and neurological recovery after ischemic stroke.PMID:35581293 | DOI:10.1038/s41401-022-00916-4 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - May 17, 2022 Category: Drugs & Pharmacology Authors: Li-Shi Fan You-Chao Chen Ru-Jia Liao Yan-Yan Zhao Xiang-Nan Zhang Zhong Chen Lei Jiang Wei-Wei Hu Source Type: research

Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis
In this study we investigated the role of APOC1 in GBM tumorigenesis. Using in silico assays we showed that APOC1 was highly expressed in GBM tissues and its expression was closely related to GBM progression. We showed that APOC1 protein expression was markedly increased in four GBM cell lines (U251, U138, A172 and U87) compared to the normal brain glia cell lines (HEB, HA1800). In U251 cells, overexpression of APOC1 promoted cell proliferation, migration, invasion and colony information, which was reversed by APOC1 knockdown. APOC1 knockdown also markedly inhibited the growth of GBM xenografts in the ventricle of nude mic...
Source: Acta Pharmacologica Sinica - May 17, 2022 Category: Drugs & Pharmacology Authors: Xiang-Jin Zheng Wen-Lin Chen Jie Yi Wan Li Jin-Yi Liu Wei-Qi Fu Li-Wen Ren Sha Li Bin-Bin Ge Yi-Hui Yang Yi-Zhi Zhang Hong Yang Guan-Hua Du Yu Wang Jin-Hua Wang Source Type: research

Antagonism of histamine H < sub > 3 < /sub > receptor promotes angiogenesis following focal cerebral ischemia
In conclusion, this study demonstrates that H3R antagonism promotes angiogenesis after cerebral ischemia, which is independent of activation of histaminergic neurons, but related to the H3R on vascular endothelial cells and its interaction with Annexin A2. Thus, H3R antagonists might be promising drug candidates to improve angiogenesis and neurological recovery after ischemic stroke.PMID:35581293 | DOI:10.1038/s41401-022-00916-4 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - May 17, 2022 Category: Drugs & Pharmacology Authors: Li-Shi Fan You-Chao Chen Ru-Jia Liao Yan-Yan Zhao Xiang-Nan Zhang Zhong Chen Lei Jiang Wei-Wei Hu Source Type: research

Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis
In this study we investigated the role of APOC1 in GBM tumorigenesis. Using in silico assays we showed that APOC1 was highly expressed in GBM tissues and its expression was closely related to GBM progression. We showed that APOC1 protein expression was markedly increased in four GBM cell lines (U251, U138, A172 and U87) compared to the normal brain glia cell lines (HEB, HA1800). In U251 cells, overexpression of APOC1 promoted cell proliferation, migration, invasion and colony information, which was reversed by APOC1 knockdown. APOC1 knockdown also markedly inhibited the growth of GBM xenografts in the ventricle of nude mic...
Source: Acta Pharmacologica Sinica - May 17, 2022 Category: Drugs & Pharmacology Authors: Xiang-Jin Zheng Wen-Lin Chen Jie Yi Wan Li Jin-Yi Liu Wei-Qi Fu Li-Wen Ren Sha Li Bin-Bin Ge Yi-Hui Yang Yi-Zhi Zhang Hong Yang Guan-Hua Du Yu Wang Jin-Hua Wang Source Type: research

Antagonism of histamine H < sub > 3 < /sub > receptor promotes angiogenesis following focal cerebral ischemia
In conclusion, this study demonstrates that H3R antagonism promotes angiogenesis after cerebral ischemia, which is independent of activation of histaminergic neurons, but related to the H3R on vascular endothelial cells and its interaction with Annexin A2. Thus, H3R antagonists might be promising drug candidates to improve angiogenesis and neurological recovery after ischemic stroke.PMID:35581293 | DOI:10.1038/s41401-022-00916-4 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - May 17, 2022 Category: Drugs & Pharmacology Authors: Li-Shi Fan You-Chao Chen Ru-Jia Liao Yan-Yan Zhao Xiang-Nan Zhang Zhong Chen Lei Jiang Wei-Wei Hu Source Type: research

Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis
In this study we investigated the role of APOC1 in GBM tumorigenesis. Using in silico assays we showed that APOC1 was highly expressed in GBM tissues and its expression was closely related to GBM progression. We showed that APOC1 protein expression was markedly increased in four GBM cell lines (U251, U138, A172 and U87) compared to the normal brain glia cell lines (HEB, HA1800). In U251 cells, overexpression of APOC1 promoted cell proliferation, migration, invasion and colony information, which was reversed by APOC1 knockdown. APOC1 knockdown also markedly inhibited the growth of GBM xenografts in the ventricle of nude mic...
Source: Acta Pharmacologica Sinica - May 17, 2022 Category: Drugs & Pharmacology Authors: Xiang-Jin Zheng Wen-Lin Chen Jie Yi Wan Li Jin-Yi Liu Wei-Qi Fu Li-Wen Ren Sha Li Bin-Bin Ge Yi-Hui Yang Yi-Zhi Zhang Hong Yang Guan-Hua Du Yu Wang Jin-Hua Wang Source Type: research

Antagonism of histamine H < sub > 3 < /sub > receptor promotes angiogenesis following focal cerebral ischemia
In conclusion, this study demonstrates that H3R antagonism promotes angiogenesis after cerebral ischemia, which is independent of activation of histaminergic neurons, but related to the H3R on vascular endothelial cells and its interaction with Annexin A2. Thus, H3R antagonists might be promising drug candidates to improve angiogenesis and neurological recovery after ischemic stroke.PMID:35581293 | DOI:10.1038/s41401-022-00916-4 (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - May 17, 2022 Category: Drugs & Pharmacology Authors: Li-Shi Fan You-Chao Chen Ru-Jia Liao Yan-Yan Zhao Xiang-Nan Zhang Zhong Chen Lei Jiang Wei-Wei Hu Source Type: research

Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia
Acta Pharmacologica Sinica, Published online: 17 May 2022; doi:10.1038/s41401-022-00916-4Antagonism of histamine H3 receptor promotes angiogenesis following focal cerebral ischemia (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - May 17, 2022 Category: Drugs & Pharmacology Authors: Li-shi Fan You-chao Chen Ru-jia Liao Yan-yan Zhao Xiang-nan Zhang Zhong Chen Lei Jiang Wei-wei Hu Source Type: research

Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis
Acta Pharmacologica Sinica, Published online: 17 May 2022; doi:10.1038/s41401-022-00917-3Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis (Source: Acta Pharmacologica Sinica)
Source: Acta Pharmacologica Sinica - May 17, 2022 Category: Drugs & Pharmacology Authors: Xiang-jin Zheng Wen-lin Chen Jie Yi Wan Li Jin-yi Liu Wei-qi Fu Li-wen Ren Sha Li Bin-bin Ge Yi-hui Yang Yi-zhi Zhang Hong Yang Guan-hua Du Yu Wang Jin-hua Wang Source Type: research