Hair stylists as Screeners for Scarring Hair Loss within the African American Community: A Cross Sectional Study.
Abstract Scarring alopecia is a common cause of hair loss in African American women, of which subtype Central Centrifugal Cicatricial Alopecia (CCCA) is the most frequent culprit.1 Both genetic predisposition and environmental factors play critical roles in CCCA development.2 CCCA progresses gradually, and patients may not seek medical attention before blatant alopecia occurs. Treatment focuses on preventing further hair loss and promoting regrowth in non-permanently scarred areas using topical, intralesional, or oral therapies. PMID: 33459357 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 18, 2021 Category: Dermatology Authors: Veerabagu SA, Lauth MJ, Obayomi A, Correa M, Murina AT Tags: Br J Dermatol Source Type: research

Black in the ivory.
Abstract To be Black in the United States is to be a minority in almost every context, including in medicine. I will be part of the 2% of physicians who are Black women in a country where 13.4% of the population is Black. I am a medical student by day and an activist by night. As a Black woman in this country, activism feels mandatory. My life could depend on it. PMID: 33454967 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 17, 2021 Category: Dermatology Authors: Ngonadi N Tags: Br J Dermatol Source Type: research

Association between hospital-diagnosed atopic dermatitis and psychiatric disorders and medication use in childhood.
CONCLUSIONS: The increased risk of treatment, but not of hospital-diagnosis of psychiatric disorders in children with hospital-diagnosed AD, suggests that psychiatric issues in children with AD could be of transient, reversible or mild-moderate nature. PMID: 33454962 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 16, 2021 Category: Dermatology Authors: Vittrup I, Andersen YMF, Droitcourt C, Skov L, Egeberg A, Fenton MC, Mina-Osorio P, Boklage S, Thyssen JP Tags: Br J Dermatol Source Type: research

Hand Eczema in Children Referred for Patch Testing: North American Contact Dermatitis Group Data, 2000-2016.
Abstract BACKGROUND: Little is known about the etiologies and relevant allergens in pediatric patients with hand eczema (HE). OBJECTIVE: To characterize the etiologies and determine proportion of positive and currently relevant allergens in children/adolescents (age
Source: The British Journal of Dermatology - January 16, 2021 Category: Dermatology Authors: Silverberg JI, Warshaw EM, Maibach HI, DeKoven JG, Taylor JS, Atwater AR, Sasseville D, Zug KA, Reeder MJ, Fowler JF, Pratt MD, Fransway AF, Zirwas MJ, Belsito DV, Marks JG, DeLeo VA Tags: Br J Dermatol Source Type: research

Oral ivermectin for a scabies outbreak in a long-term-care facility: Potential value in preventing COVID-19 and associated mortality?
Abstract To-date, COVID-19 pandemic affected>85 million persons worldwide with 14% severe and 5% critical, and a general population case-fatality rate of 1%. Age is the main risk factor for severe disease and death1 making the long-term-care facilities (LTCFs) residents particularly vulnerable.2 COVID-19 therapeutic agents remain sparce and ivermectin, an antiparasitic showed anti-SARS-CoV-2 activity in vitro.3 Moxidectin, another macrocyclic lactone, with a longer plasma half-life, could be considered too. PMID: 33454964 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 16, 2021 Category: Dermatology Authors: Bernigaud C, Guillemot D, Ahmed-Belkacem A, Grimaldi-Bensouda L, Lespine A, Berry F, Softic L, Chenost C, Do-Pham G, Giraudeau B, Fourati S, Chosidow O Tags: Br J Dermatol Source Type: research

A multicenter study of nevus-associated melanoma versus de novo melanoma, tumor thickness and body site differences.
CONCLUSIONS: Clinicopathological and body site differences between de novo melanoma and NAM support divergent pathways of development. These differences were also found in thin melanomas, suggesting that de novo melanomas are different from NAM and their differences are not due to the obliteration of nevus remnants in thicker tumors. PMID: 33454993 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 16, 2021 Category: Dermatology Authors: Dessinioti C, Geller AC, Stergiopoulou A, Dimou N, Lo S, Keim U, Gershenwald JE, Haydu LE, Dummer R, Mangana J, Hauschild A, Egberts F, Vieira R, Brinca A, Zalaudek I, Deinlein T, Evangelou E, Thompson JF, Scolyer RA, Peris K, Garbe C, Stratigos AJ Tags: Br J Dermatol Source Type: research

Identification of compound heterozygous mutations in AP1B1 leading to the newly-described recessive keratitis-ichthyosis-deafness (KIDAR) syndrome.
scher J Abstract Recently, mutations in Adaptor Related Protein Complex 1 Subunit Beta 1 (AP1B1) have been identified as the cause of a new form of syndromic ichthyosis, which is characterized by neonatal onset of ichthyosis, erythroderma and deafness accompanied by failure to thrive and developmental delay.(1,2) In adulthood, keratitis has been diagnosed as well.(1) Based on the observed phenotype and the autosomal-recessive mode of inheritance, the disease has been classified as a keratitis-ichthyosis-deafness syndrome (KIDAR; OMIM:242150). In this letter, we describe an additional case of KIDAR caused by AP1B1 ...
Source: The British Journal of Dermatology - January 16, 2021 Category: Dermatology Authors: Vornweg J, Gläser S, Ahmad-Anwar M, Zimmer AD, Kuhn M, Hörer S, Korenke GC, Grothaus J, Ott H, Fischer J Tags: Br J Dermatol Source Type: research

Minimal, superficial DNA damage in human skin from filtered far-ultraviolet-C (UV-C).
Abstract Krypton-Chloride (Kr-Cl) excimer lamps have a peak emission wavelength of 222 nm in the ultraviolet-C (UV-C) region of the electromagnetic spectrum. Currently Kr-Cl lamps are the only viable "far-UV-C" sources for full-room inactivation of airborne SARS-CoV-2, the virus responsible for the COVID-19 pandemic1 . Commercially available Kr-Cl excimer lamps can be retro-fitted to existing room lamp fittings or mounted at ceiling height independently. Other technologies, such as light emitting diodes (LEDs), are currently neither efficient nor powerful enough for such a task. PMID: 33452809 [PubM...
Source: The British Journal of Dermatology - January 16, 2021 Category: Dermatology Authors: Hickerson RP, Conneely MJ, Tsutsumi SKH, Wood K, Jackson DN, Ibbotson SH, Eadie E Tags: Br J Dermatol Source Type: research

Agminated benign vascular tumor successfully treated with Trametinib.
Abstract Vascular tumours are caused by the neoplastic transformation of cells constituting vascular structures. Traditionally, treatment options include surgical approaches such as resection, embolization/sclerotherapy, or laser therapy, and medical treatments such as corticosteroids, beta-blockers, and chemotherapy. The investigation of genetic mutations underlying vascular anomalies has recently provided new insights into the genetic aetiology of these lesions,1 giving rise to personalized, targeted medical treatment that may potentially be safer and more effective. Here, we describe a patient who presented wit...
Source: The British Journal of Dermatology - January 16, 2021 Category: Dermatology Authors: Greenberger S, Stein R, Ollech A, Hartstein ME, Benyamini O, Yalon M, Levi A, Lapidoth M, Barzilai A Tags: Br J Dermatol Source Type: research

Relationship between type 2 diabetes mellitus and markers of cutaneous melanoma aggressiveness: An observational multi-centric study in 443 patients with melanoma.
CONCLUSIONS: T2DM, rather than glycaemic control and metformin treatment, is associated with increased cutaneous melanoma aggressiveness at diagnosis. PMID: 33453061 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 16, 2021 Category: Dermatology Authors: Nagore E, Martinez-Garcia MA, Gomez-Olivas JD, Manrique-Silva E, Martorell A, Bañuls J, Carrera C, Ortiz P, Gardeazabal J, Boada A, de Eusebio E, Chiner E, Gonzalez C, Pérez-Gil A, Cullen D, Formigón M, de Unamuno B, Navarro-Soriano C, Muriel A, Gozal Tags: Br J Dermatol Source Type: research

Interventions for basal cell carcinoma: abridged Cochrane systematic review and grade assessments.
CONCLUSIONS: Surgical interventions have lower recurrence rates and remain the gold-standard for high-risk BCC. Of the non-surgical treatments, topical imiquimod has the best evidence to support its efficacy for low-risk BCC. Priorities for future research include agreement on core outcome measures and studies with longer follow-up. PMID: 33448328 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 15, 2021 Category: Dermatology Authors: Thomson J, Hogan S, Leonardi-Bee J, Williams HC, Bath-Hextall FJ Tags: Br J Dermatol Source Type: research

Development or exacerbation of hidradenitis suppurativa in two transgender men after initiation of testosterone therapy.
Abstract Transgender individuals are a growing patient population with unique dermatologic needs. Masculinizing hormone therapy (MHT) involves the use of exogenous testosterone to promote masculine and suppress feminine secondary sex characteristics.1 Commonly reported cutaneous effects of MHT include acne vulgaris and androgenic alopecia.2 To our knowledge, there have been no reported cases of hidradenitis suppurativa (HS) among transgender patients receiving MHT. Herein we present two patients, one that developed HS and one with worsening HS symptoms after initiating MHT. PMID: 33448331 [PubMed - as supplie...
Source: The British Journal of Dermatology - January 15, 2021 Category: Dermatology Authors: Buonomo M, Mansh MD, Thorpe D, Goldfarb N Tags: Br J Dermatol Source Type: research

Clinical Photography in Skin of Color: Tips and Best Practices.
Abstract High quality photos are critical to dermatology: both for clinical care and education. Although best practices for capturing skin photos have been outlined,1 these omit specific challenges of taking photos of dark skin. Bias against accurate capture of dark skin in photographic technology is a longstanding issue2 . Film photography colour balance relied on reference cards portraying white models2 , and digital photography still has issues capturing detailed photos of darker skin. PMID: 33448346 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 15, 2021 Category: Dermatology Authors: Lester JC, Clark L, Linos E, Daneshjou R Tags: Br J Dermatol Source Type: research

A 1% glycopyrronium bromide cream for the topical treatment of primary axillary hyperhidrosis: Efficacy and Safety Results from a Phase 3a Randomised Controlled Study.
CONCLUSION: 1% GPB cream may provide an effective new treatment option exhibiting a good safety profile for patients with primary axillary hyperhidrosis. The long-term open-label part (Phase 3b) is ongoing. PMID: 33445205 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 14, 2021 Category: Dermatology Authors: Abels C, Soeberdt M, Kilic A, Reich H, Knie U, Jourdan C, Schramm K, Heimstaedt-Muskett S, Masur C, Szeimies RM Tags: Br J Dermatol Source Type: research

Inducible skin-associated lymphoid tissue (iSALT) in a patient with Schnitzler syndrome who manifested wheals on recurrent localized erythema.
Abstract Schnitzler syndrome is characterized by a chronic urticarial rash with an intermittent fever, and is considered to be an acquired form of autoinflammatory syndrome because its clinical phenotypes are similar to cryopyrin-associated periodic syndrome with a gain-of-function mutation in NLRP3.1 Patients with Schnitzler syndrome also exhibit IgM monoclonal gammopathy, and 15-20% of patients eventually develop a lymphoproliferative disorder resembling Waldenström macroglobulinemia with an MYD88 mutation.2 At present, the precise pathogenesis of Schnitzler syndrome remains unknown. PMID: 33445206 [Pu...
Source: The British Journal of Dermatology - January 14, 2021 Category: Dermatology Authors: Kamido H, Shimomiya D, Kogame T, Takimoto-Ito R, Kataoka TR, Hirata M, Ueshima C, Otsuka A, Ghazawi FM, Nomura T, Kambe N, Kabashima K Tags: Br J Dermatol Source Type: research

Diagnostic value of cutaneous manifestation of SARS-CoV-2 infection.
CONCLUSIONS: Skin rashes cluster with other COVID-19 symptoms, are predictive of a positive swab test, and occur in a significant number of cases, either alone or before other classical symptoms. Recognising rashes is important in identifying new and earlier COVID-19 cases. PMID: 33448030 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 14, 2021 Category: Dermatology Authors: Visconti A, Bataille V, Rossi N, Kluk J, Murphy R, Puig S, Nambi R, Bowyer RCE, Murray B, Bournot A, Wolf J, Ourselin S, Steves CJ, Spector TD, Falchi M Tags: Br J Dermatol Source Type: research

Revolutionizing Atopic Dermatitis, 13-14 December 2020.
Authors: PMID: 33432586 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 11, 2021 Category: Dermatology Tags: Br J Dermatol Source Type: research

Differential Profiles of Gamma-Secretase-Notch Signaling in Hidradenitis Suppurativa: The Need for Genotype-Endotype-Phenotype Analysis.
Abstract Hidradenitis Suppurativa (HS) is a chronic inflammatory dermatosis in which a subset of patients display genetic variants in components of the gamma secretase complex1 proposed to result in dysregulation of Notch signaling2 . This pathogenic paradigm has been highly influential in providing a succinct explanation for the pathogenesis of HS, however the molecular data supporting the hypothesis has been relatively sparse, and largely derived from East Asian populations3,4 . The incidence of Gamma-Secretase associated polymorphisms been demonstrated to be significantly lower in Caucasian populations5 , imply...
Source: The British Journal of Dermatology - January 9, 2021 Category: Dermatology Authors: Frew JW Tags: Br J Dermatol Source Type: research

COVID-19-associated cutaneous manifestations: does HHV-6 play an etiological role?
;a M, Gilaberte Y Abstract Recently, during the development of COVID-19 pandemic, several publications have warned of possible cutaneous manifestations in association with this novel coronavirus (SARS-CoV-2). In our hospital we have created a multidisciplinary unit with a specific protocol to attend patients with these manifestations. Inclusion criteria consisted of patients who, during the development of the pandemic, were clinically suspected and/or microbiologically confirmed of COVID-19 and had a recent-onset skin rash (within the last 4 weeks). All patients underwent biochemistry, hematimetry and serology for...
Source: The British Journal of Dermatology - January 8, 2021 Category: Dermatology Authors: Abadías-Granado I, Navarro-Bielsa A, Morales-Callaghan AM, Roc L, Suso-Estívalez CC, Povar-Echeverría M, Gilaberte Y Tags: Br J Dermatol Source Type: research

COVID-19 related dermatosis in November 2019. Could this case be Italy's patient zero?
tti E Abstract Milan, the largest city in northern Italy, was one of the first European metropolitan areas to be affected by the COVID-19 pandemic. We analyzed skin biopsies of patients from Milan with dermatoses and positive PCR swabs for SARS-CoV-2 at different stages of the infection (1,2). The results were compared to skin biopsies of 20 COVID-19 non-diagnosed patients with dermatoses, who were at high-risk of COVID-19 infection. PMID: 33410129 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 7, 2021 Category: Dermatology Authors: Gianotti R, Barberis M, Fellegara G, Galván-Casas C, Gianotti E Tags: Br J Dermatol Source Type: research

Obstructive Sleep Apnea in Psoriasis and Hidradenitis Suppurativa.
Abstract Obstructive sleep apnoea (OSA) is an independent risk factor for the development of cardiovascular disease. Epidemiological studies report that the prevalence of OSA in psoriasis patients (1) and in hidradenitis suppurativa (HS) patients is higher than healthy control populations. (2) This is the first prospective study to use formal sleep studies to assess the prevalence of OSA in HS. PMID: 33404093 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 6, 2021 Category: Dermatology Authors: Kelly A, Meurling J, Kirthi Jeyarajah S, Ryan C, Hughes R, Garvey J, Kirby B Tags: Br J Dermatol Source Type: research

Cellulitis in chronic oedema of the lower leg: an international cross-sectional study.
CONCLUSIONS: Cellulitis in chronic leg oedema is a global problem. Several risk factors for cellulitis were identified, of which some are potentially preventable. Our findings suggest that oedema control, is one of these. We also identified that advanced stages of oedema, with hard/fibrotic tissue, might be an important clinical indicator to identify patients at particular risk. PMID: 33405247 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 6, 2021 Category: Dermatology Authors: Burian EA, Karlsmark T, Franks PJ, Keeley V, Quéré I, Moffatt CJ Tags: Br J Dermatol Source Type: research

Targeting the expression of T antigens with Selinexor (KPT-330) shows promise for MCPyV-positive Merkel cell carcinoma treatment.
Abstract Merkel cell carcinoma (MCC) is a rare primary neuroendocrine skin cancer. In the Northern hemisphere, the disease most commonly arises as a result of infection with Merkel cell polyomavirus (MCPyV).1 Although the incidence of MCC is only 0.7 per 100,000 individuals in the United States, this number is increasing worldwide, and the cancer is highly aggressive, often carrying a poor prognosis.2 Immunotherapies such as pembrolizumab have emerged as leading treatments for MCPyV-associated MCC; however, only a subset of patients respond to these agents, and many require other treatments to remain in remission....
Source: The British Journal of Dermatology - January 5, 2021 Category: Dermatology Authors: Gupta R, Simonette RA, Doan HQ, Rady PL, Tyring SK Tags: Br J Dermatol Source Type: research

Huriez syndrome caused by a large deletion that abrogates the skin-specific isoform of SMARCAD1.
Abstract Huriez syndrome (HRZ ; MIM181600) is a rare autosomal dominant genodermatosis, which is characterised by scleroatrophy of the hands and feet, hypoplasia of the nails and palmoplantar keratoderma1,2 . Approximately 15% of HRZ patients are predisposed to cutaneous squamous cell carcinoma (cSCC) which occurs in affected scleroatrophic skin at an early age of 30 to 40 years. cSCC in HRZ may be aggressive, with metastasis and death reported3 . PMID: 33400266 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 5, 2021 Category: Dermatology Authors: Loh AYT, Ho CM, Muthiah S, Venkatesh B, Zwolinski S, Bray APJJ, Reversade B, Rajan N, Carney TJ Tags: Br J Dermatol Source Type: research

Activity and components of the G-CSF pathway in hidradenitis suppurativa.
CONCLUSIONS: The G-CSF pathway engages both tissue and immune cells, is strongly activated in HS lesions, and offers the opportunity to target the neutrophil-driven inflammation. PMID: 33400270 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 5, 2021 Category: Dermatology Authors: Wolk K, Brembach TC, Šimaitė D, Bartnik E, Cucinotta S, Pokrywka A, Irmer ML, Triebus J, Witte-Händel E, Salinas G, Leeuw T, Volk HD, Ghoreschi K, Sabat R Tags: Br J Dermatol Source Type: research

Image guided lymph node core needle biopsy predicts survival in mycosis fungoides and S ézary syndrome.
CONCLUSIONS: CNB allows an objective assessment of the LN involvement in MF/SS, relevant for staging and prognosis. PMID: 33400272 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 5, 2021 Category: Dermatology Authors: Calvani J, de Masson A, de Margerie-Mellon C, de Kerviler É, Ram-Wolff C, Gruber A, Meignin V, Brice P, Sadoux A, Mourah S, Bagot M, Battistella M Tags: Br J Dermatol Source Type: research

Modular gene analysis reveals distinct molecular signatures for cutaneous lupus patient subsets.
CONCLUSION: Our data support a diverse molecular profile in CLE that further adds to the clinical variations of this skin disease, and may affect disease course and treatment selection. Future studies with a larger and diverse CLE patient cohort are warranted to confirm these findings. PMID: 33400293 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 5, 2021 Category: Dermatology Authors: Zhu JL, Tran LT, Smith M, Zheng F, Cai L, James JA, Guthridge JM, Chong BF Tags: Br J Dermatol Source Type: research

Opsin 5 is a key regulator of ultraviolet radiation induced melanogenesis in human epidermal melanocytes.
CONCLUSION: Our results provide insight into the molecular mechanisms of UVR in melanocytes and may reveal molecular targets for preventing pigmentation or pigment diseases. PMID: 33400324 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 5, 2021 Category: Dermatology Authors: Lan Y, Zeng W, Dong X, Lu H Tags: Br J Dermatol Source Type: research

Recommended core outcome instruments for health-related quality of life, long-term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting.
CONCLUSIONS: For now, the core outcome set for clinical trials in AE is complete. The specified domains and instruments should be used in all new clinical trials and systematic reviews of eczema treatments. PMID: 33393074 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 4, 2021 Category: Dermatology Authors: Thomas KS, Apfelbacher CA, Chalmers JR, Simpson E, Spuls PI, Gerbens LAA, Williams HC, Schmitt J, Gabes M, Howells L, Stuart BL, Grinich E, Pawlitschek T, Burton T, Howie L, Gadkari A, Eckert L, Ebata T, Boers M, Saeki H, Nakahara T, Katoh N Tags: Br J Dermatol Source Type: research

Cutaneous immune-related adverse events in patients with melanoma treated with checkpoint inhibitors.
Abstract Checkpoint inhibitor (CPI) therapy has vastly improved long-term outcomes in metastatic malignant melanoma (MMM). Therapy takes the form of monoclonal antibody infusions that target immune cell checkpoint proteins, such as cytotoxic T-lymphocyte-associated protein 4 (CTLA4) and programmed death 1/programmed death ligand 1 (PD1/PDL1). Cutaneous immune-related adverse effects (IrAEs) are frequent in patients with MMM treated with CPIs. Our aim was to review the clinical presentations of cutaneous IrAEs associated with CPI therapy in adult patients with MMM. We carried out a literature review of clinical tri...
Source: The British Journal of Dermatology - January 4, 2021 Category: Dermatology Authors: Gault A, Anderson AE, Plummer R, Stewart C, Pratt AG, Rajan N Tags: Br J Dermatol Source Type: research

CERKL is upregulated in cutaneous squamous cell carcinoma and maintains cellular sphingolipids and resistance to oxidative stress.
CONCLUSIONS: These findings suggest that CERKL may be important in cSCC progression and could lead to novel strategies for prevention and treatment of cSCC. PMID: 33393080 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 4, 2021 Category: Dermatology Authors: Meyer JM, Lee E, Celli A, Park K, Cho R, Lambert W, Pitchford M, Gordon M, Tsai K, Cleaver J, Arron ST, Mauro TM Tags: Br J Dermatol Source Type: research

Genotypic and phenotypic analysis of 34 cases of inherited junctional epidermolysis bullosa caused by COL17A1 mutations.
We report 34 patients with JEB with COL17A1 genetic mutations diagnosed in our centre between 1993 and 2019. Medical and biological records were collected with a standardized questionnaire. For immunofluorescence (IF) analyses of skin biopsies, we used the monoclonal antibody to collagen XVII HD233 (Dr Owaribe, Japan). PMID: 33393081 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 4, 2021 Category: Dermatology Authors: Hérissé AL, Charlesworth A, Bellon N, Leclerc-Mercier S, Bourrat E, Hadj-Rabia S, Bodemer C, Lacour JP, Chiaverini C Tags: Br J Dermatol Source Type: research

Expanding the use of allogeneic haematopoietic cell transplantation in dermatology.
PMID: 33398873 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 4, 2021 Category: Dermatology Authors: Bauer JW Tags: Br J Dermatol Source Type: research

A growing family of outcome measurement proposals for hidradenitis suppurativa.
PMID: 33398878 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 4, 2021 Category: Dermatology Authors: Emtestam L, Lapins J, Sartorius K Tags: Br J Dermatol Source Type: research

Total Body Photography for the Diagnosis of Cutaneous Melanoma in Adults: A Systematic Review and Meta-Analysis.
CONCLUSIONS: Available data regarding the diagnostic accuracy of TBP are heterogeneous, due to variability in the risk profile of cohorts and TBP protocols. Best current estimates suggest that TBP for diagnosing melanoma has an acceptable NNB in high-risk patients. However, prospective diagnostic test accuracy studies are needed to accurately gauge the diagnostic accuracy of TBP. PMID: 33369727 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 28, 2020 Category: Dermatology Authors: Ji-Xu A, Dinnes J, Matin RN Tags: Br J Dermatol Source Type: research

Online decision aid for patients with psoriasis.
Abstract There are many treatment options for psoriasis and it can be challenging to choose the best option for an individual patient. Evidence based medicine indicates treatment decisions should be based on the best available evidence, physicians' clinical expertise and the values and desires of the patient. While guidelines and meta-analysis support physicians by providing overviews of the evidence, a recent systematic review showed that the patient perspective is often underexposed in consultations with psoriasis patients.(1). PMID: 33369728 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 28, 2020 Category: Dermatology Authors: van der Kraaij GE, van Huizen AM, Baerveldt EM, Boshuizen M, Determann D, van Ee I, Hageman M, de Kort W, Tafuni G, Smeets PMG, Spuls PI Tags: Br J Dermatol Source Type: research

Tape Strips in Dermatology Research.
Abstract Tape strips have been used widely in dermatology research as a minimally-invasive method to sample the epidermis, avoiding the need for skin biopsies. Most research has focused on epidermal pathology, such as atopic eczema, but there is increasing research into the use of tape strips in other dermatoses, such as skin cancer and the microbiome. This review summarises the technique of tape stripping, and discusses which dermatoses have been studied by tape stripping and alternative minimally-invasive sampling methods. We review the number of tapes strips needed from each patient and the components of the ep...
Source: The British Journal of Dermatology - December 28, 2020 Category: Dermatology Authors: Hughes AJ, Tawfik SS, Baruah KP, O'Toole EA, O'Shaughnessy RFL Tags: Br J Dermatol Source Type: research

Multifocal Myositis and Elevated CPK associated with the use of Ustekinumab for Hidradenitis Suppurativa.
Abstract ustekinumab (UST) is a human interleukin (IL)-12/IL-23 monoclonal antibody that has been approved by the Food and Drug Administration (FDA) to treat moderate to severe plaque psoriasis, psoriatic arthritis, and Crohn's disease. Off-label use of UST has shown promising results for hidradenitis suppurativa (HS) in patients that have failed therapy with adalimumab, the only FDA approved treatment for HS. PMID: 33370450 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 28, 2020 Category: Dermatology Authors: Smith J, Ezekwe N, Pourang A, Hamzavi I Tags: Br J Dermatol Source Type: research

Low-dose oral minoxidil improves global hair density and length in children with loose anagen hair syndrome.
Abstract Loose anagen hair syndrome (LAHS) is a sporadic or autosomal dominant hair disorder which typically affects girls aged 2-6 years.1 It is characterised by increased hair shedding, non-scarring alopecia, inability to grow long hair, dull and lustreless hair. Premature and defective keratinisation of the inner root sheath (IRS), and impaired anchorage of anagen hairs underlie the pathogenesis.1 A favourable response has been demonstrated in three patients with LAHS treated with topical minoxidil.1-3 Low-dose oral minoxidil (LDOM) has been shown to be effective in adult androgenetic alopecia, alopecia areata ...
Source: The British Journal of Dermatology - December 24, 2020 Category: Dermatology Authors: Jerjen R, Koh WL, Sinclair R, Bhoyrul B Tags: Br J Dermatol Source Type: research

Risk mitigating behaviours in people with inflammatory skin and joint disease during the COVID-19 pandemic differ by treatment type: a cross-sectional patient survey.
CONCLUSIONS: Greater risk-mitigating behaviour among people with IMIDs receiving targeted therapies may contribute to the reported lower risk of adverse COVID-19 outcomes. The behaviour variation across treatment groups, IMIDs and nations reinforces the need for clear evidence-based patient communication on risk mitigation strategies and may help inform updated public health guidelines as the pandemic continues. PMID: 33368145 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 23, 2020 Category: Dermatology Authors: Mahil SK, Yates M, Langan SM, Yiu ZZN, Tsakok T, Dand N, Mason KJ, McAteer H, Meynell F, Coker B, Vincent A, Urmston D, Vesty A, Kelly J, Lancelot C, Moorhead L, Bachelez H, Bruce IN, Capon F, Contreras CR, Cope AP, De La Cruz C, Di Meglio P, Gisondi P, H Tags: Br J Dermatol Source Type: research

Fludarabine modulates expression of type VII collagen during haematopoietic stem cell transplantation for recessive dystrophic epidermolysis bullosa.
CONCLUSIONS: Fludarabine influences the production of type VII collagen in RDEB fibroblasts. PMID: 33368156 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 23, 2020 Category: Dermatology Authors: Vanden Oever M, Muldoon D, Mathews W, Tolar J Tags: Br J Dermatol Source Type: research

Tralokinumab for atopic dermatitis: a promising new therapy.
PMID: 33347600 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 21, 2020 Category: Dermatology Authors: Morra DE, Drucker AM Tags: Br J Dermatol Source Type: research

Head-to-head comparison of biologics in psoriasis: better acceleration does not necessarily win all races.
PMID: 33347616 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 21, 2020 Category: Dermatology Authors: Puig L Tags: Br J Dermatol Source Type: research

Efficacy and safety of fumaric acid esters in young patients aged 10 to 17 years with moderate-to-severe plaque psoriasis - A randomised, double-blinded, placebo-controlled trial.
Abstract BACKGROUND: Apart from three biologics, no systemic drugs are approved in Europe for children with moderate-to-severe psoriasis. Retrospective observational studies showed promising results for fumaric acid esters (FAE) in this setting. OBJECTIVES: To show superiority of FAE over placebo in terms of treatment response after 20 weeks in children and adolescents aged 10-17 years. METHODS: In a multicentre, randomised, double-blind, placebo-controlled phase 3b study patients aged 10-17 years with moderate-to-severe plaque psoriasis requiring systemic therapy were randomised 2:1 to receive FAE (N=91...
Source: The British Journal of Dermatology - December 17, 2020 Category: Dermatology Authors: Hamm H, Wilsmann-Theis D, Tsianakas A, Gambichler T, Taipale K, Lauterbach J, Freudensprung U, Makepeace C, KIFUderm study investigators Tags: Br J Dermatol Source Type: research

Interleukin-18 is a sensitive marker of flair initiation in Adamantiades-Beh çet's disease.
Interleukin-18 is a sensitive marker of flair initiation in Adamantiades-Behçet's disease. Br J Dermatol. 2020 Dec 17;: Authors: Zouboulis CC, Altenburg A Abstract Adamantiades-Behçet's disease (ABD; MIM 109650) is a rare, neutrophilic vascular reaction or vasculitis with a chronic recurrent progressive course leading to systemic inflammatory vascular disease with potentially severe prognosis.1 Its aetiology remains unknown. A genetic predisposition, triggered by infection/environmental factor(s) leading to hyperergic immunological reaction/damage of the vascular endothelium is assumed. ...
Source: The British Journal of Dermatology - December 17, 2020 Category: Dermatology Authors: Zouboulis CC, Altenburg A Tags: Br J Dermatol Source Type: research

Words Matter: A randomized controlled study evaluating the impact of decision-framing on treatment preferences in adults with psoriasis and psoriatic arthritis.
Abstract Decision-framing describes how choices are presented or framed.1 A choice can be worded either positively (gain-framed) to explain the benefits of a therapy, or negatively (loss-framed) to explain the risks of not taking a therapy. In the management of chronic diseases, patients' agreement with clinician recommendations during the shared decision making process predicts long-term adherence to therapies.2-5 In this randomized controlled trial, we examined the effects of gain- versus loss-framing on patient preferences for a proposed therapy among psoriasis patients with and without psoriatic arthritis (PsA...
Source: The British Journal of Dermatology - December 17, 2020 Category: Dermatology Authors: Kassardjian AA, Chat VS, Archuleta L, Hekmatjah J, Sierro TJ, Read C, Chen AY, Singh I, Armstrong AW Tags: Br J Dermatol Source Type: research

SARS-CoV-2 has not been detected directly by electron microscopy in the endothelium of chilblain lesions: reply from the authors.
, Torrelo A PMID: 33325537 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 16, 2020 Category: Dermatology Authors: Colmenero I, Santonja C, Alonso-Riaño M, Andina D, Rodríguez Peralto JL, Requena L, Torrelo A Tags: Br J Dermatol Source Type: research

Unpicking the Gordian knot of identifying metastasis development-relevant proteins in cutaneous squamous cell carcinoma.
PMID: 33325538 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 16, 2020 Category: Dermatology Authors: Tobin DJ Tags: Br J Dermatol Source Type: research

Treatment of multiple facial basal cell carcinomas in a child with xeroderma pigmentosum complementation group C with Mohs micrographic surgery.
PMID: 33325539 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 16, 2020 Category: Dermatology Authors: Greig A, Aloni K, Orchard G, Shams M, Craythorne E, Fassihi H Tags: Br J Dermatol Source Type: research

A child's experience of itch: the first step towards patient-centred measures.
PMID: 33319357 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 15, 2020 Category: Dermatology Authors: Zigler CK, Roberts A Tags: Br J Dermatol Source Type: research