Extensive scalp ulcer secondary to delusional infestation treated with antipsychotics and scalp reconstruction.
o MMS PMID: 32052414 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 12, 2020 Category: Dermatology Authors: Pincelli MS, Guimarãres ALM, Milcheski DA, Dwan AJ, Nico MMS Tags: Br J Dermatol Source Type: research

Reading through genetic 'stop signs': a therapeutic strategy in genetic skin disease.
PMID: 32037506 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 9, 2020 Category: Dermatology Authors: Kibbi N, Rajan N Tags: Br J Dermatol Source Type: research

IP-10/CXCR3 axis is associated with HHV-6 reactivation and the development of sequelae in drug reaction with eosinophilia and systemic symptoms.
CONCLUSIONS: Higher plasma IP-10 levels are associated with the development of long-term sequelae in DRESS. Higher IP-10/CXCR3 expression in skin and more abundant CLA+ CXCR3+ CD4+ cells and CLA+ CXCR3+ CD8+ cells were observed in DRESS patients with HHV-6 reactivation. The IP-10/CXCR3 axis is associated with HHV-6 reactivation and development of long-term sequelae in DRESS. PMID: 32037509 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 9, 2020 Category: Dermatology Authors: Yang CW, Cho YT, Hsieh YC, Hsu SH, Chen KL, Chu CY Tags: Br J Dermatol Source Type: research

Declining levels of serum CXCL10 over time are associated with new onset of psoriatic arthritis in patients with psoriasis: A new biomarker?
Abstract BACKGROUND: We previously found that serum levels of C-X-C motif chemokine 10 (CXCL10) decreased after PsA onset. OBJECTIVE: We measured CXCL10 levels over time in psoriasis patients who developed PsA to determine whether the drop in CXCL10 was specific to these patients and further assess its association with PsA development. METHODS: Prospectively followed psoriasis patients without arthritis (psoriasis cutaneous [PsC]) were assessed yearly by rheumatologists for the presence of PsA. PsC patients who developed PsA (converters) were matched to those that did not develop PsA (non-converters) bas...
Source: The British Journal of Dermatology - February 9, 2020 Category: Dermatology Authors: Abji F, Lee K, Math M, Pollock RA, Machhar R, Cook RJ, Chandran V, Gladman DD Tags: Br J Dermatol Source Type: research

Drug survival and post-drug survival of systemic treatments in a national French cohort of children with atopic dermatitis.
We described the IS use (first and second-line) for children with AD in a French retrospective national cohort, by using two survival analyses: 'drug survival' (DS, defined as the duration of treatment) and 'post-drug survival' (PDS, defined as the time between the end of first-line and the beginning of second-line). PMID: 32037515 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 9, 2020 Category: Dermatology Authors: Chambrelan E, Barbarot S, Bekel L, Poizeau F, Mahé E, Puzenat E, Delaunay J, Mallet S, Bessis D, Maruani A, Miquel J, Raison-Peyron N, Abasq C, Phan A, Du Thanh A, Kupfer I, Bonniaud B, Bouzille G, Dupuy A, Droitcourt C, Groupe de Recherche sur l’Eczé Tags: Br J Dermatol Source Type: research

The 2020 IACS Consensus Criteria for the Diagnosis of Scabies.
CONCLUSIONS: The 2020 IACS Criteria represent a pragmatic, yet robust set of diagnostic features and methods. The criteria may be implemented in a range of research, public health and clinical settings by selecting the appropriate diagnostic levels and subcategories. These criteria may provide greater consistency and standardisation for scabies diagnoses. Validation studies and development of training materials and development of survey methods are now required. PMID: 32034956 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 8, 2020 Category: Dermatology Authors: Engelman D, Yoshizumi J, Hay RJ, Osti M, Micali G, Norton S, Walton S, Boralevi F, Bernigaud C, Bowen AC, Chang AY, Chosidow O, Estrada-Chavez G, Feldmeier H, Ishii N, Lacarrubba F, Mahé A, Maurer T, Mahdi MMA, Murdoch ME, Pariser D, Nair PA, Rehmus W, R Tags: Br J Dermatol Source Type: research

Basal cell carcinoma: an emerging epidemic in women in Iceland.
CONCLUSIONS: This is the only reported population in which the incidence of BCC is significantly higher in women than in men. The period of notable increase in BCC lesions correlates with the period of increase in tanning bed and travel popularity. The high multiplicity rates suggest that total tumor burden worldwide might be higher than previously thought. PMID: 32030719 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 7, 2020 Category: Dermatology Authors: Adalsteinsson JA, Ratner D, Olafsdóttir E, Grant-Kels J, Ungar J, Silverberg JI, Kristjansson AK, Jonasson JG, Tryggvadottir L Tags: Br J Dermatol Source Type: research

Racial and Ethnic Disparities in Global Atopic Dermatitis Clinical Trials.
Abstract Atopic dermatitis (AD) is a chronic inflammatory dermatosis affecting up to 20% of children and 3% of adults.1 Historically AD was more prevalent in more developed nations. However, recent trends indicate an increasing prevalence in developing regions, including Southeast Asian countries, Mexico, Chile, Kenya, and Algeria. PMID: 32030728 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 7, 2020 Category: Dermatology Authors: Price KN, Krase JM, Loh TY, Hsiao JL, Shi VY Tags: Br J Dermatol Source Type: research

A feasibility study of microwave therapy for precancerous actinic keratoses.
Abstract BACKGROUND: Actinic keratosis (AK) is a common pre-malignant skin lesion that can progress to cutaneous squamous cell carcinoma (cSCC). Microwave therapy is an established cancer treatment and has been used for plantar viral warts. OBJECTIVES: To evaluate the efficacy and feasibility of microwave as a treatment for AK. METHODS: Stage 1 was a dose-setting study, where seven participants had the dielectric properties of 12 thick and 22 thin AK assessed for optimisation of the microwave dose used for treatment in Stage 2. Stage 2 was a randomised, internally-controlled trial evaluating 179 AK in 11...
Source: The British Journal of Dermatology - February 6, 2020 Category: Dermatology Authors: Jackson DN, Hogarth FJ, Sutherland D, Holmes EM, Donnan PT, Proby CM Tags: Br J Dermatol Source Type: research

Method for the accurate determination of the DNA protection factor of sun protection products.
This study addresses an important issue in skin photoprotection: the prevention of the accumulation of DNA damage. Solar UV radiation is readily absorbed by DNA and triggers the formation of dimeric pyrimidine photoproducts such as cyclobutane pyrimidine dimers (CPDs). One purpose of sun protection products is to decrease the biological consequences of overexposure to sunlight and in particular prevent the formation of mutagenic CPDs1 which play major roles in the initiation of skin tumors. PMID: 32030725 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 6, 2020 Category: Dermatology Authors: Josse G, Gravier E, Douki T Tags: Br J Dermatol Source Type: research

Artificial intelligence in dermatology: the "unsupervised" learning.
Artificial intelligence in dermatology: the "unsupervised" learning. Br J Dermatol. 2020 Feb 06;: Authors: Acharya P, Mathur M Abstract The potential areas of application of artificial intelligence in dermatology are ever-increasing. With the wide availability of smartphones equipped with high-resolution cameras and impressive processing powers, harnessing these capabilities using machine learning (ML) could open new prospects in the management of dermatological disorders. Du-Harpur et al. have done a commendable job reviewing the utility of artificial intelligence in dermatology in an easil...
Source: The British Journal of Dermatology - February 6, 2020 Category: Dermatology Authors: Acharya P, Mathur M Tags: Br J Dermatol Source Type: research

Association of blood mercury levels with nonmelanoma skin cancer in the U.S.A. using National Health and Nutrition Examination Survey data (2003-2016).
CONCLUSIONS: We found that higher blood tHg and MeHg levels were associated with a higher prevalence of NMSC. PMID: 32020585 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 5, 2020 Category: Dermatology Authors: Rhee J, Vance TM, Lim R, Christiani DC, Qureshi AA, Cho E Tags: Br J Dermatol Source Type: research

Validation of Patient-Reported Outcomes Information System Sleep Disturbance and Sleep-Related Impairment in Adults With Atopic Dermatitis.
Abstract BACKGROUND: Sleep disturbances (SD) are common in adults with atopic dermatitis (AD). Patient-Reported Outcomes Measurement Information System (PROMIS™) SD and Sleep-Related Impairment (SRI) are validated questionnaires to assess sleep in adults. Little is known about their measurement properties in adults with AD. OBJECTIVE: To assess the measurement properties of PROMIS SD and SRI 8-item short-forms in AD. METHODS: We performed a prospective dermatology practice-based study using questionnaires and evaluation by a dermatologist (n=420). RESULTS: PROMIS SD/SRI showed moderate correla...
Source: The British Journal of Dermatology - February 4, 2020 Category: Dermatology Authors: Lei D, Yousaf M, Janmohamed SR, Vakharia PP, Chopra R, Sacotte R, Patel KR, Singam V, Immaneni S, Kantor R, Hsu DY, Silverberg JI Tags: Br J Dermatol Source Type: research

Development of a new patient-reported outcome measure to assess activities and participation in people with systemic sclerosis: The Cochin 17-item Scleroderma Functional Scale.
CONCLUSIONS: The CSF-17 is a new patient-reported outcome assessing activities and participation specifically in people with SSc. Its content and construct validities are very good. PMID: 32017013 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 4, 2020 Category: Dermatology Authors: Daste C, Abdoul H, Foissac F, Papelard A, Alami S, Kwakkenbos L, Carrier ME, Lefèvre-Colau MM, Thombs BD, Poiraudeau S, Rannou F, Mouthon L, Nguyen C Tags: Br J Dermatol Source Type: research

Consensus re-classification of inherited epidermolysis bullosa and other disorders with skin fragility.
CONCLUSION: The proposed classification scheme should be of value both to clinicians and researchers, emphasizing both clinical and genetic features of EB. PMID: 32017015 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 4, 2020 Category: Dermatology Authors: Has C, Bauer JW, Bodemer C, Bolling M, Bruckner-Tuderman L, Diem A, Fine JD, Heagerty A, Hovnanian A, Marinkovich P, Martinez AE, McGrath JA, Moss C, Murrell DF, Palisson F, Schwieger-Briel A, Sprecher E, Tamai K, Uitto J, Woodley DT, Zambruno G, Mellerio Tags: Br J Dermatol Source Type: research

Long-term and multiple hospital readmissions after discharge for Stevens-Johnson Syndrome and toxic epidermal necrolysis.
Abstract Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are characterized by blistering and necrosis of skin and mucosa. Hospitalization for SJS/TEN was associated with a short-term (30-day) readmission rate of 10.3%1 . Little is known about longer-term and/or multiple readmissions. PMID: 32017033 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 4, 2020 Category: Dermatology Authors: Cheng BT, Silverberg JI Tags: Br J Dermatol Source Type: research

Light brown structureless areas as predictor of melanoma in situ.
Abstract Although dermoscopic criteria and algorithms have been developed to increase sensitivity and specificity of melanoma diagnosis, the detection of thin melanoma, in particular melanoma in situ (MIS) can still present some difficulties. PMID: 32017037 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 4, 2020 Category: Dermatology Authors: Filoni A, Lospalluti L, Zanframundo G, De Marco A, Argenziano G, Bonamonte D Tags: Br J Dermatol Source Type: research

Healthcare resource utilization and payer cost analysis of patients with prurigo nodularis.
Abstract Prurigo nodularis (PN) is a chronic dermatosis characterized by severely pruritic nodules on the trunk and extensor surfaces. In addition to its skin manifestations, PN is also associated with a variety of systemic conditions.1,2,3 Furthermore, many patients with PN are refractory to therapy with no FDA-approved agents available to date.4 Despite challenges in management and a significant burden of comorbidities in PN, there are limited studies examining healthcare utilization in this condition.5 Herein we use a medical claims from a large, ambulatory cohort to describe real-world healthcare utilization a...
Source: The British Journal of Dermatology - February 4, 2020 Category: Dermatology Authors: Huang AH, Canner JK, Williams KA, Grossberg AL, Kwatra MM, Kwatra SG Tags: Br J Dermatol Source Type: research

Three-dimensional neuroanatomy of the intra-epidermal nervous system.
Abstract Intra-epidermal nerve fibers (IENFs) are presumed to comprise mainly of itch-transmitting nerve fibers, and variations in their density have been studied in itch disorders; epidermal nerve fiber density is also a criterion in diagnosing small fiber neuropathy in clinical neurological practice. IENFs are typically identified with 2-dimensional (2D) histological slides, but 2D sections do not accurately represent nerves, which branch out in three-dimensions (3D). PMID: 32017051 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 4, 2020 Category: Dermatology Authors: Tan Y, Ning ZY, Yu X, Kwong BLT, Ng LG, Tey HL Tags: Br J Dermatol Source Type: research

Phenotype and function of circulating memory T cells 1 in human vitiligo.
CONCLUSIONS: The decreased frequency of circulating Th1/Tc1, Th17/Tc17 and Th1/Th17-70 Tc1/Tc17 cells suggests a possible migration of these T cell subsets into the skin of patients that could be targeted to prevent the flare of the disease. PMID: 32012221 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 3, 2020 Category: Dermatology Authors: Martins C, Darrigade AS, Jacquemin C, Barnetche T, Taieb A, Ezzedine K, Boniface K, Seneschal J Tags: Br J Dermatol Source Type: research

Who dies from thin melanoma?
PMID: 32017009 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 3, 2020 Category: Dermatology Authors: Cust AE Tags: Br J Dermatol Source Type: research

Measuring what's important to adolescents with psoriasis.
PMID: 32017024 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 3, 2020 Category: Dermatology Authors: Blome C Tags: Br J Dermatol Source Type: research

Secukinumab in patients with psoriasis who have responded inadequately to tumour necrosis factor inhibitor treatment.
PMID: 32017027 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 3, 2020 Category: Dermatology Authors: Tsai TF Tags: Br J Dermatol Source Type: research

Broadening indications for neoadjuvant immunotherapy.
PMID: 32017031 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 3, 2020 Category: Dermatology Authors: Blankenstein SA, van Akkooi ACJ Tags: Br J Dermatol Source Type: research

Among the brightest antipsoriatic stars.
PMID: 32017032 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 3, 2020 Category: Dermatology Authors: Meier K, Ghoreschi K Tags: Br J Dermatol Source Type: research

Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi.
Abstract Congenital melanocytic naevi (CMNs, commonly known as "moles") are made up of pigment cells which contain a gene that has undergone an alteration (mutation). We know that different moles have different genetic mutations (or "genotypes"), and also that different moles look and behave differently, that is they have different "phenotypes". Very rarely a CMN can be linked with problems in the brain or can even develop into a malignant tumour (melanoma). These researchers in London reviewed 156 CMNs from 134 children to see whether specific genotypes cause particular phenotypes. T...
Source: The British Journal of Dermatology - February 1, 2020 Category: Dermatology Authors: Polubothu S, McGuire N, Al-Olabi L, Baird W, Bulstrode N, Chalker J, Josifova D, Lomas D, O'Hara J, Ong J, Rampling D, Stadnik P, Thomas A, Wedgeworth E, Sebire NJ, Kinsler VA Tags: Br J Dermatol Source Type: research

Dermoscopy in general dermatology: a 'Delphinitive' step forward.
PMID: 32017017 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 1, 2020 Category: Dermatology Authors: Bahadoran P Tags: Br J Dermatol Source Type: research

The road to real-time, bedside, optical imaging pathology: basal cell carcinoma and beyond.
PMID: 32017020 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 1, 2020 Category: Dermatology Authors: Navarrete-Dechent C, Marghoob AA, Chen CJ Tags: Br J Dermatol Source Type: research

Facets of shame are differently expressed in dermatological disease: A prospective observational study.
Abstract The recent years have witnessed a growing interest in clinical research on the experience of shame and its associations with psychological functioning and well-being. Shame is a self-regulatory function of the body in adapting to the social environment as well as maintaining and restoring self-esteem and self-acceptance. PMID: 31997342 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 30, 2020 Category: Dermatology Authors: Aberer E, Hiebler-Ragger M, Zenker M, Weger W, Hofer A, Unterrainer HF Tags: Br J Dermatol Source Type: research

Commentary: Ligelizumab for chronic spontaneous urticaria.
Abstract Chronic spontaneous urticaria (CSU) is a very disabling condition. It can be difficult to treat. Less than 50% of people respond to licenced dosages of H1-antihistamines (though up-dosing where safe increases the response rate). Additionally, only a small proportion respond to the addition of the leukotriene receptor antagonist (LTRA) montelukast.1,2. PMID: 32002982 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 30, 2020 Category: Dermatology Authors: Sabroe RA Tags: Br J Dermatol Source Type: research

A novel approach to understanding potential risk factors for venous leg ulceration.
PMID: 32002984 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 30, 2020 Category: Dermatology Authors: Magin P Tags: Br J Dermatol Source Type: research

Real-world data for direct stage-specific costs of melanoma healthcare.
Abstract In Europe, melanoma is the fourth most common cancer diagnosed in young adults (20 to 45 years old) [1]. It also has one of the fastest-growing incidence rates globally, and this trend is expected to continue in all European countries [2]. Thus, also due to the costly new treatment options available, the economic burden of this illness is expected to keep increasing as well [3]. PMID: 31997306 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 29, 2020 Category: Dermatology Authors: Buja A, Rivera M, De Polo A, Zorzi M, Carpin E, Vecchiato A, Del Fiore P, Martin G, Saia M, Baldo V, Rugge M, Rossi CR Tags: Br J Dermatol Source Type: research

Eczema and water hardness: another piece of the puzzle found?
PMID: 31994183 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 29, 2020 Category: Dermatology Authors: Arents BWM, Leonardi-Bee J Tags: Br J Dermatol Source Type: research

Outcomes of Pregnancies from the Tildrakizumab Phase 1-3 Clinical Development Program.
Abstract Approximately 50% of patients with psoriasis are female, the majority of whom are of childbearing potential. Tildrakizumab, a high-affinity, humanised, immunoglobulin (Ig)G1κ, anti-interleukin (IL)-23p19 monoclonal antibody, demonstrated efficacy in treatment of moderate to severe chronic plaque psoriasis and was well tolerated in clinical studies. IgG antibodies are actively transported across the placental barrier via placental Fc receptors beginning at approximately gestational week 13. PMID: 31995637 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 29, 2020 Category: Dermatology Authors: Haycraft K, DiRuggiero D, Rozzo SJ, Mendelsohn AM, Bhutani T Tags: Br J Dermatol Source Type: research

Baricitinib in Patients with Moderate-to-Severe Atopic Dermatitis and Inadequate Response to Topical Corticosteroids: Results from Two Randomised Monotherapy Phase 3 Trials.
aller AS, Wollenberg A, Reich K Abstract BACKGROUND: Baricitinib, an oral selective Janus kinase 1 and 2 inhibitor, effectively reduced atopic dermatitis (AD) severity in a Phase 2 study with concomitant topical corticosteroids. OBJECTIVES: To evaluate the efficacy and safety of baricitinib in patients with moderate-to-severe AD and an inadequate response to topical therapies. METHODS: In two independent, multicentre, double-blind, Phase 3 monotherapy trials, BREEZE-AD1 and BREEZE-AD2, adults with moderate-to-severe AD were randomised 2:1:1:1 to once-daily placebo, baricitinib 1-mg, 2-mg or 4-mg for 16 w...
Source: The British Journal of Dermatology - January 29, 2020 Category: Dermatology Authors: Simpson EL, Lacour JP, Spelman L, Galimberti R, Eichenfield LF, Bissonnette R, King BA, Thyssen JP, Silverberg JI, Bieber T, Kabashima K, Tsunemi Y, Costanzo A, Guttman-Yassky E, Beck LA, Janes JM, DeLozier AM, Gamalo M, Brinker DR, Cardillo T, Nunes FP, Tags: Br J Dermatol Source Type: research

A behaviour change package to prevent hand dermatitis in nurse working in the National Health Service: results of a cluster randomised controlled trial.
CONCLUSION: There was insufficient evidence to conclude whether our intervention was effective in reducing hand dermatitis in our populations. PMID: 31989580 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 27, 2020 Category: Dermatology Authors: Madan I, Parsons V, Ntani G, Coggon D, Wright A, English J, McCrone P, Smedley J, Rushton L, Murphy C, Cookson B, Williams HC Tags: Br J Dermatol Source Type: research

Methotrexate treatment for psoriasis patients and risk of cutaneous melanoma: a nested case-control study.
CONCLUSIONS: In this Swedish nested case-control study, the use of MTX was not associated with an enhanced risk for CMM. These findings are reassuring to dermatologists in everyday clinical practice. PMID: 31981364 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 25, 2020 Category: Dermatology Authors: Polesie S, Gillstedt M, Paoli J, Osmancevic A Tags: Br J Dermatol Source Type: research

'Efficacy and safety of imiquimod 5% cream for basal cell carcinoma: a meta-analysis of randomized controlled trial'; a critical appraisal.
Abstract AIM: Jia and He1 aimed 'to compare the efficacy and safety of imiquimod with other treatments in patients with basal cell carcinoma (BCC)'. DESIGN AND INCLUSION CRITERIA: Meta-analysis of studies that included patients with histologically-confirmed BCC treated with imiquimod 5% cream compared to all other treatments, including vehicle, excisional surgery, cryosurgery, fluorouracil and methylaminolevulinate photodynamic therapy (MAL-PDT). OUTCOMES: Main outcome measures included histological / composite clearance rates, success rates, complete response rates, tumour free survival and adverse even...
Source: The British Journal of Dermatology - January 24, 2020 Category: Dermatology Authors: Olabi B, Tasker F, Williams HC Tags: Br J Dermatol Source Type: research

Successful treatment of Netherton syndrome with ustekinumab in a 15-year-old girl.
Abstract Netherton syndrome (NS) is a rare autosomal recessive ichthyosis syndrome, which manifests at birth or shortly thereafter, and is characterized by erythroderma, ichthyosis linearis circumflexa, trichorrhexis invaginata, immunodeficiency, failure to thrive and high serum IgE level.1 Approximately 80 different mutations in exonic and intronic regions of the SPINK5 gene have been reported, resulting in deficiency of lymphoepithelial Kazal type inhibitor (LEKTI), a serine protease inhibitor in epithelia, thymus, tonsils, parathyroid glands and trachea. Treatment of NS has always been challenging2 , but eviden...
Source: The British Journal of Dermatology - January 24, 2020 Category: Dermatology Authors: Volc S, Maier L, Gritsch A, Aichelburg MC, Volc-Platzer B Tags: Br J Dermatol Source Type: research

The Alopecia Areata Investigator's Global Assessment (AA-IGA ™) Scale: A Measure for Evaluating Clinically Meaningful Success in Clinical Trials.
CONCLUSIONS: We recommend the use of the SALT to assess the extent (0-100%) of scalp hair loss. Using the SALT assessment, the AA-IGA™ is a robust ordinal measure providing distinct and clinically meaningful gradations of scalp hair loss that reflects patients' and expert clinicians' perspectives and treatment expectations. PMID: 31970750 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 23, 2020 Category: Dermatology Authors: Wyrwich KW, Kitchen H, Knight S, Aldhouse NVJ, Macey J, Nunes FP, Dutronc Y, Mesinkovska N, Ko JM, King BA Tags: Br J Dermatol Source Type: research

Rosacea treatment guideline for The Netherlands.
Abstract The classification of rosacea has evolved from a subtyping into a phenotype approach1-3 and an updated systematic review on interventions in rosacea using this approach was recently published.4 Therefore, we developed a new evidence-based guideline for all physicians and skin therapists involved in the management of patients suffering from rosacea. A patient information leaflet based on this guideline was produced. The Working Group (WG) consisted of dermatologists (4), general practitioner (1), ophthalmologist (1), plastic surgeon (1), skin therapists (2), patient (1) and staff members of the Dutch Socie...
Source: The British Journal of Dermatology - January 23, 2020 Category: Dermatology Authors: van Zuuren EJ, van der Linden MMD, Arents BWM Tags: Br J Dermatol Source Type: research

Identification of cases and estimate of direct costs of unresectable and advanced cutaneous squamous cell carcinoma: real-world data from a large Italian database.
Abstract Precise epidemiology data on cutaneous Squamous-Cell Carcinoma (cSCC) are difficult to obtain since: the tumour is not included in many cancer registries; when included, only the first tumour is usually registered, in spite of frequent occurrence of subsequent lesions; the tumour's traceability may be incomplete due to usual management in the outpatient or private setting. A systematic review reported that the incidence of cSCC varies widely worldwide and is on the rise(1). Consequently, cSCC is an emergent public health problem, with costs ranging from £33 to £46 million each year(2). PM...
Source: The British Journal of Dermatology - January 23, 2020 Category: Dermatology Authors: Ronconi G, Piccinni C, Dondi L, Calabria S, Pedrini A, Esposito I, Ascierto PA, Naldi L, Martini N Tags: Br J Dermatol Source Type: research

Effect of narrowband ultraviolet B treatment on micro RNA expression in active non-segmental generalized vitiligo.
Abstract Non-segmental generalized vitiligo (NSGV) is the most common and progressive clinical form of vitiligo1 and NB-UVB is most preferred and effective treatment modality in aNSGV.2 Effect of NB-UVB treatment on micro RNA (miRNA) expression and its association with clinical outcome in active NSGV (aNSGV) is not known. miRNA are non-coding oligonucleotides that are known to regulate various biological processes and implicated in variety of human diseases.3 Limited studies are available suggesting the role of miRNA in vitiligo pathogenesis but precise mechanism of action is not known. PMID: 31975367 [PubMed...
Source: The British Journal of Dermatology - January 23, 2020 Category: Dermatology Authors: Parihar AS, Tembhre MK, Sharma VK, Gupta S, Chattopadhyay P, Deepak KK Tags: Br J Dermatol Source Type: research

A trial-based cost-effectiveness analysis of topical 5-fluorouracil vs imiquimod vs ingenol mebutate vs methylaminolevulinate conventional photodynamic therapy for the treatment of actinic keratosis in the head and neck area performed in the Netherlands.
CONCLUSIONS: Based on these results, we consider 5% 5-FU cream as first choice treatment option for multiple AK in the head and neck area. PMID: 31961446 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 21, 2020 Category: Dermatology Authors: Jansen MHE, Kessels JPHM, Merks I, Nelemans PJ, Kelleners-Smeets NWJ, Mosterd K, Essers BAB Tags: Br J Dermatol Source Type: research

Congenital melanocytic naevi. Who benefits from a therapy?
PMID: 31956984 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 20, 2020 Category: Dermatology Authors: Krengel S Tags: Br J Dermatol Source Type: research

Pain in atopic dermatitis: it's time we addressed this symptom further.
PMID: 31956992 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 20, 2020 Category: Dermatology Authors: Fuxench ZCC Tags: Br J Dermatol Source Type: research

A new model of human telogen-anagen transformation helps decipher Wnt signalling in the human hair cycle.
PMID: 31957004 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 20, 2020 Category: Dermatology Authors: Philpott M Tags: Br J Dermatol Source Type: research

Management of symptomatic mucosal involvement in paediatric pachyonychia congenita.
PMID: 31957008 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 20, 2020 Category: Dermatology Authors: Youssefian L, Vahidnezhad H Tags: Br J Dermatol Source Type: research

Quality of life in the photodermatoses: the hidden toll of photosensitivity.
PMID: 31957009 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 20, 2020 Category: Dermatology Authors: Walburn J, Sarkany RPE Tags: Br J Dermatol Source Type: research

Rituximab with prednisolone as first-line treatment in pemphigus vulgaris.
PMID: 31957012 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 20, 2020 Category: Dermatology Authors: Scorer M, Setterfield JF, Harman KE Tags: Br J Dermatol Source Type: research