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Analysis of anti-TNF-induced skin lesions reveals strong Th1 activation with some distinct immunological characteristics.
CONCLUSIONS: New-onset anti-TNF-α-induced eruptions previously classified as psoriasis or spongiotic dermatitis (eczema) exhibit a molecular profile that is different from either of these disorders. This article is protected by copyright. All rights reserved. PMID: 29143979 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 16, 2017 Category: Dermatology Authors: Stoffel E, Maier H, Riedl E, Brüggen MC, Reininger B, Schaschinger M, Bangert C, Guenova E, Stingl G, Brunner PM Tags: Br J Dermatol Source Type: research

High plasma 25-hydroxyvitamin D and high risk of non-melanoma skin cancer: a Mendelian randomisation study of 97849 individuals.
zal S Abstract BACKGROUND: High plasma 25-hydroxyvitamin D (25 (OH)D) concentration has been associated observationally with high risk of non-melanoma skin cancer, while many studies suggest that vitamin D could have a protective effect on cancer. The true association between vitamin D and risk of skin cancer remains unclear. OBJECTIVES: In this Mendelian randomisation study we tested the hypothesis that genetically high plasma 25(OH)D protects against non-melanoma skin cancer. METHODS: We included 103084 individuals from the Danish general population, of whom 35 298 had plasma 25(OH)D measured and 97849...
Source: The British Journal of Dermatology - November 16, 2017 Category: Dermatology Authors: Winsløw UC, Nordestgaard BG, Afzal S Tags: Br J Dermatol Source Type: research

Molecular photoprotection of human keratinocytes in vitro by the naturally occurring mycosporine-like amino acid (MAA) palythine.
Abstract BACKGROUND: Solar ultraviolet radiation (UVR) induces molecular and genetic changes in the skin, which result in skin cancer, photoageing and photosensitivity disorders. The use of sunscreens is advocated to prevent such photodamage, however most formulations contain synthetic UVR filters that are non-biodegradable and can damage fragile marine ecosystems. Mycosporine-like amino acids (MAA) are natural UVR-absorbing compounds that have evolved in marine species for protection against chronic UVR exposure in shallow-water habitats. OBJECTIVES: To determine if palythine, a photostable model MAA, could ...
Source: The British Journal of Dermatology - November 13, 2017 Category: Dermatology Authors: Lawrence KP, Gacesa R, Long PF, Young AR Tags: Br J Dermatol Source Type: research

Generating new evidence, improving clinical practice and developing research capacity: the benefits of recruiting to the U.K. Dermatology Clinical Trials Network's STOP GAP and BLISTER trials.
Abstract Clinical trials may benefit clinical practice in three ways: firstly, clinicians may change their practice according to the new trial evidence; secondly, clinical processes can improve when working on a trial; and thirdly, research capacity is increased. We held a meeting to present and discuss the results of two large multicentre randomized controlled trials delivered through the U.K. Dermatology Clinical Trials Network. Investigators gave reflections on how the trials had changed their clinical practice. The STOP GAP trial showed that prednisolone and ciclosporin are equally effective as first-line syst...
Source: The British Journal of Dermatology - November 10, 2017 Category: Dermatology Authors: Batchelor JM, Chapman A, Craig FE, Harman KE, Kirtschig G, Martin-Clavijo A, Ormerod AD, Walton S, Williams HC Tags: Br J Dermatol Source Type: research

Response to "Providing dermatological care in resource-limited settings: barriers and potential solutions".
This article is protected by copyright. All rights reserved. PMID: 29124736 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 9, 2017 Category: Dermatology Authors: Mahé A, Faye O Tags: Br J Dermatol Source Type: research

Psychological stress and psoriasis. A systematic review and meta-analysis.
Abstract BACKGROUND: Psychological stress has long been linked with psoriasis exacerbation/onset. However, it is unclear if they are associated. OBJECTIVE: To determine if antecedent psychological stress and psoriasis exacerbation/onset are associated. METHODS: A comprehensive search of Pubmed, PsycINFO, Cochrane library, and clinicaltrials. gov databases was performed. Studies investigating the association between preceding psychological stress and psoriasis exacerbation/onset were classified as cross-sectional, case-control or cohort. Surveys evaluating beliefs regarding stress-reactivity were analysed...
Source: The British Journal of Dermatology - November 9, 2017 Category: Dermatology Authors: Snast I, Reiter O, Atzmony L, Leshem YA, Hodak E, Mimouni D, Pavlovsky L Tags: Br J Dermatol Source Type: research

Response to "Providing dermatological care in resource-limited settings: barriers and potential solutions" - reply from authors.
This article is protected by copyright. All rights reserved. PMID: 29124750 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 9, 2017 Category: Dermatology Authors: Chang AY, Kiprono SK, Maurer TA Tags: Br J Dermatol Source Type: research

Fumaric acid esters in combination with a 6-week course of narrow-band UVB provides for an accelerated response as compared to fumaric acid esters monotherapy in patients with moderate to severe plaque psoriasis: A randomized prospective clinical study.
CONCLUSIONS: Adding a 6-week course of narrow-band UVB to FAE both accelerates and augments the therapeutic response during the early phase of treatment and increases quality of life in patients with moderate-to-severe plaque psoriasis. This article is protected by copyright. All rights reserved. PMID: 29114862 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 8, 2017 Category: Dermatology Authors: Tzaneva S, Geroldinger A, Trattner H, Tanew A Tags: Br J Dermatol Source Type: research

Immunohistochemical expression of vitamin D receptor in melanocytic nevi and cutaneous melanoma. A case-control study.
acute;lez S Abstract BACKGROUND: Vitamin D (VD) deficiency is associated with higher risk of cancer, possibly due to anti-proliferative, anti-angiogenic, pro-apoptotic, cell-differentiating and anti-invasive effects. The anti-carcinogenic role of VD in melanoma is still a matter of debate. Loss of nuclear and cytoplasmic vitamin D Receptor (VDR) expression in melanoma cells has been reported. OBJECTIVE: To analyze VDR immunohistochemical expression in benign dermal nevi (DN) and MM. METHODS: A case-control study evaluated nuclear and cytoplasmic VDR immunohistochemical staining in 54 DN and 55 MM tissue ...
Source: The British Journal of Dermatology - November 6, 2017 Category: Dermatology Authors: Del Puerto C, Navarrete-Dechent C, Molgó M, Camargo CA, Borzutzky A, González S Tags: Br J Dermatol Source Type: research

Prevalence and incidence of chronic spontaneous urticaria in the entire Korean adult population.
This article is protected by copyright. All rights reserved. PMID: 29106703 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 6, 2017 Category: Dermatology Authors: Kim YS, Park SH, Han K, Bang CH, Lee JH, Park YM Tags: Br J Dermatol Source Type: research

A systematic review of diagnostic criteria for psoriasis in adults and children: Evidence from studies with a primary aim to develop or validate diagnostic criteria.
CONCLUSION: Clinical examination-based diagnostic criteria are currently lacking for psoriasis. Future research could follow an international collaborative approach and employ high quality diagnostic accuracy study design. Existing and newly developed criteria require validation. This article is protected by copyright. All rights reserved. PMID: 29106713 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 6, 2017 Category: Dermatology Authors: Burden-Teh E, Phillips RC, Thomas KS, Ratib S, Grindlay D, Murphy R Tags: Br J Dermatol Source Type: research

Safety, efficacy, and drug survival of biologics and biosimilars for moderate-to-severe plaque psoriasis.
CONCLUSIONS: Ustekinumab was associated with the highest drug survival, and secukinumab with the lowest, albeit that most patients on secukinumab were non-naïve. Switching from originator to biosimilar had no significant impact on drug survival, and the safety profiles were comparable. Adverse events occurred most frequently with secukinumab. Future studies are warranted to assess the long-term safety of novel biologics for psoriasis. This article is protected by copyright. All rights reserved. PMID: 29094341 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 1, 2017 Category: Dermatology Authors: Egeberg A, Ottosen MB, Gniadecki R, Broesby-Olsen S, Dam TN, Bryld LE, Rasmussen MK, Skov L Tags: Br J Dermatol Source Type: research

Population-based Clinical Practice Research Datalink study using algorithm modelling to identify the true burden of hidradenitis suppurativa.
CONCLUSIONS: Contrary to results of previous population-based studies, HS is relatively common, with a UK prevalence of 0.77%, one-third being unrecognised, criteria-diagnosed cases using the most stringent disease definition. If probable cases are included, HS prevalence rises to 1.19%. This article is protected by copyright. All rights reserved. PMID: 29094346 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 1, 2017 Category: Dermatology Authors: Ingram JR, Jenkins-Jones S, Knipe DW, Morgan CLI, Cannings-John R, Piguet V Tags: Br J Dermatol Source Type: research

THE NON-NEURONAL AND NON-MUSCULAR EFFECTS OF BOTULINUM TOXIN: A Graceful Opportunity for a Deadly Molecule to Treat a Human Disease in the Skin and Beyond.
This article is protected by copyright. All rights reserved. PMID: 29086923 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 31, 2017 Category: Dermatology Authors: Grando SA, Zachary CB Tags: Br J Dermatol Source Type: research

Research gaps in the management and prevention of cutaneous squamous cell carcinoma in organ transplant recipients.
Abstract Although tremendous progress has been made in recent years in skin cancer care for organ transplant recipients, significant gaps remain in data-driven clinical guidelines, particularly for the treatment and prevention of cutaneous squamous cell carcinoma (cSCC), the most common malignancy among this population. In this review, we aim to summarize current knowledge around the management of cSCC and highlight the most significant gaps in knowledge that continue to pose challenges in the delivery of skin cancer care for organ transplant recipients. We suggest future directions for research that will bridge e...
Source: The British Journal of Dermatology - October 30, 2017 Category: Dermatology Authors: Blomberg M, He SY, Harwood C, Arron ST, Demehri S, Green A, Asgari MM, NCI Keratinocyte Carcinoma Consortium Tags: Br J Dermatol Source Type: research

The pathogenesis of cutaneous squamous cell carcinoma in organ transplant recipients.
We present an overview of those factors for which there is currently the most convincing evidence and highlight important gaps in our knowledge. In particular, a clear understanding of the interdependence and relative contributions of these co-factors is currently lacking, yet has important implications for rational development of clinically relevant biomarkers and targeted strategies for treatment and prevention of post-transplant keratinocyte cancers. PMID: 29086420 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 30, 2017 Category: Dermatology Authors: Harwood CA, Toland AE, Proby CM, Euvrard S, Hofbauer GFL, Tommasino M, Bouwes Bavinck JN, KeraCon Consortium Tags: Br J Dermatol Source Type: research

Towards global consensus on core outcomes for Hidradenitis Suppurativa research: An update from the HISTORIC consensus meetings I and II.
CONCLUSIONS: The HISTORIC consensus meetings I and II will be followed by further e-Delphi rounds to finalize the core domain set, building on the work of the in-person consensus meetings. This article is protected by copyright. All rights reserved. PMID: 29080368 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 28, 2017 Category: Dermatology Authors: Thorlacius L, Garg A, Ingram JR, Villumsen B, Theut Riis P, Gottlieb AB, Merola JF, Dellavalle R, Ardon C, Baba R, Bechara FG, Cohen AD, Daham N, Davis M, Emtestam L, Fernandez-Penas P, Filippelli M, Gibbons A, Grant T, Guilbault S, Gulliver S, Harris C, Tags: Br J Dermatol Source Type: research

A systematic review and meta-analysis of utility estimates in melanoma.
This article is protected by copyright. All rights reserved. PMID: 29077983 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: Tran AD, Fogarty G, Nowak AK, Espinoza D, Rowbotham N, Stockler MR, Morton RL Tags: Br J Dermatol Source Type: research

Postzygotic mosa ïcism and incontinentia pigmenti in male patients:molecular diagnosis yield.
This article is protected by copyright. All rights reserved. PMID: 29077987 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: Alabdullatif Z, Coulombe J, Steffann J, Bodemer C, Hadj-Rabia S Tags: Br J Dermatol Source Type: research

Laser treatment of congenital melanocytic nevi: a systematic review.
This article is protected by copyright. All rights reserved. PMID: 29077988 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: Eggen CAM, Lommerts JE, van Zuuren EJ, Limpens J, Pasmans SGMA, Wolkerstorfer A Tags: Br J Dermatol Source Type: research

Supervised exercise training as an adjunct therapy for venous leg ulcers: a randomised controlled feasibility trial.
CONCLUSIONS: Our findings support the feasibility and acceptability of both the supervised exercise programme in conjunction with compression therapy and the study procedures. The next step will be the design and implementation of an appropriately-powered, multi-centre trial. This article is protected by copyright. All rights reserved. PMID: 29077990 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: Klonizakis M, Tew GA, Gumber A, Crank H, King B, Middleton G, Michaels JA Tags: Br J Dermatol Source Type: research

Epidemiology of Staphylococcal Scalded Skin Syndrome in United States Children.
Abstract BACKGROUND: Staphylococcal scalded skin syndrome (SSSS) is a blistering dermatosis caused by exfoliative toxins released from Staphylococcus aureus. We sought to describe the incidence, costs, length of stay (LOS), comorbidities, and mortality of SSSS in US children. METHODS: The Nationwide Inpatient Sample 2008-2012 was analyzed, including a 20% sample of US hospitalizations and 589 cases of SSSS. RESULTS: The annual incidence of SSSS was 7.67 (range: 1.83-11.88) per-million US children, with 45.1 cases per-million US infants age
Source: The British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: Staiman A, Hsu DY, Silverberg JI Tags: Br J Dermatol Source Type: research

Natural history and clinical outcome of junctional epidermolysis bullosa generalized intermediate due to a LAMA3 mutation.
This article is protected by copyright. All rights reserved. PMID: 29077994 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: Reimer A, Schwieger-Briel A, He Y, Leppert J, Schauer F, Kiritsi D, Schneider H, Ott H, Bruckner-Tuderman L, Has C Tags: Br J Dermatol Source Type: research

In vivo Zika virus detection in human skin.
This article is protected by copyright. All rights reserved. PMID: 29078002 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: Cordel N, Hébert V, Vega Rua A, Herrmann-Storck C Tags: Br J Dermatol Source Type: research

Job change facilitates healing in a cohort of patients with occupational hand eczema.
CONCLUSION: Change of profession has a beneficial effect on eczema parameters, but a negative effect on HR-QoL, indicated by increased DLQI. Change of work procedures while staying in the same profession positively influenced improvement, with no marked influence on HR-QoL, and should be considered as an alternative to job change. This article is protected by copyright. All rights reserved. PMID: 29078013 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: Carøe TK, Ebbehøj NE, Bonde JPE, Vejlstrup SG, Agner T Tags: Br J Dermatol Source Type: research

Stress and Skin Disease Quality of Life: The Moderating Role of Anxiety Sensitivity Social Concerns.
CONCLUSIONS: Stress was linked to skin disease-related emotional and functional impairment associated with skin disease among individuals with high AS social concerns. These results highlight the potential for AS reduction interventions to break the vicious cycle of stress and skin disease symptoms and to improve psychosocial well-being in dermatology patients. This article is protected by copyright. All rights reserved. PMID: 29078254 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 27, 2017 Category: Dermatology Authors: Dixon LJ, Witcraft SM, McCowan NK, Brodell RT Tags: Br J Dermatol Source Type: research

The role of the microbiome in psoriasis: moving from disease description to treatment prediction?
This article is protected by copyright. All rights reserved. PMID: 29071712 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 26, 2017 Category: Dermatology Authors: Langan EA, Griffiths CEM, Solbach W, Knobloch JK, Zillikens D, Thaçi D Tags: Br J Dermatol Source Type: research

HLA-Cw6 and psoriasis.
This article is protected by copyright. All rights reserved. PMID: 29072309 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 26, 2017 Category: Dermatology Authors: Chen L, Tsai TF Tags: Br J Dermatol Source Type: research

Insulin-Like Growth Factor-II mRNA-Binding Protein 3 as a Novel Prognostic Biomarker for Acral Lentiginous Melanoma.
This article is protected by copyright. All rights reserved. PMID: 29048737 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 19, 2017 Category: Dermatology Authors: Seo JW, Ha SM, Song KH Tags: Br J Dermatol Source Type: research

Seasonality of hair loss: a time series analysis of Google Trends data 2004 to 2016.
This article is protected by copyright. All rights reserved. PMID: 29048738 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 19, 2017 Category: Dermatology Authors: Hsiang EY, Semenov YR, Aguh C, Kwatra SG Tags: Br J Dermatol Source Type: research

Severity strata for five patient-reported outcomes in adults with atopic dermatitis.
CONCLUSIONS: Existing strata for POEM and DLQI perform well in adult AD. Previously reported strata for VAS-itch performed best for NRS-itch. We identified banding for the raw ItchyQoL for our AD population that varies slightly from the banding published for a more heterogeneous population. Finally, we proposed strata for mean ItchyQOL and 5-D itch scale in adult AD. This article is protected by copyright. All rights reserved. PMID: 29048751 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 19, 2017 Category: Dermatology Authors: Vakharia PP, Chopra R, Sacotte R, Patel N, Immaneni S, White T, Kantor R, Hsu DY, Simpson EL, Silverberg JI Tags: Br J Dermatol Source Type: research

Successful treatment of SAPHO syndrome with apremilast.
This article is protected by copyright. All rights reserved. PMID: 29034454 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 16, 2017 Category: Dermatology Authors: Adamo S, Nilsson J, Krebs A, Steiner U, Cozzio A, French LE, Kolios AGA Tags: Br J Dermatol Source Type: research

Phase IV head-to-head randomised controlled trial comparing ingenol mebutate 0.015% gel with diclofenac sodium 3% gel for the treatment of actinic keratosis on the face or scalp.
ML, Skov T Abstract BACKGROUND: Ingenol mebutate (IngMeb) and diclofenac sodium (DS) are approved treatments for actinic keratosis (AK). OBJECTIVES: Compare efficacy and safety of IngMeb 0.015% gel with DS 3% gel. METHODS: Patients with 4-8 visible, discrete AK lesions on face/scalp in a 25 cm(2) contiguous area of skin were randomised 1:1 to IngMeb once-daily for 3 consecutive days, or DS twice-daily for 90 days, following label instruction. Patients presenting with AK lesions at Week 8 following IngMeb were offered a second IngMeb course. The primary endpoint was complete clearance of AK lesions ...
Source: The British Journal of Dermatology - October 14, 2017 Category: Dermatology Authors: Stockfleth E, Harwood CA, Serra Guillén C, Larsson T, Østerdal ML, Skov T Tags: Br J Dermatol Source Type: research

Dynamics of Plasma Cytokines in a Patient with Deficiency of Interleukin-36 Receptor Antagonist Successfully Treated with Anakinra.
This article is protected by copyright. All rights reserved. PMID: 29030861 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 13, 2017 Category: Dermatology Authors: Podlipnik S, Morgado-Carrasco D, Fustà-Novell X, Mensa-Vilaró A, Arostegui JI, Alsina-Gibert M, Mascaró JM Tags: Br J Dermatol Source Type: research

Comment on: A Visual Literacy Course for Dermatology Trainees.
This article is protected by copyright. All rights reserved. PMID: 29030868 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 13, 2017 Category: Dermatology Authors: Gardham N, Walsh S Tags: Br J Dermatol Source Type: research

Comparison of injection site reactions between the etanercept biosimilar SB4 and the reference etanercept in patients with rheumatoid arthritis from a Phase III study.
This article is protected by copyright. All rights reserved. PMID: 29023641 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 11, 2017 Category: Dermatology Authors: Girolomoni G, Feldman SR, Emery P, Ghil J, Keum JW, Cheong SY, Hong E Tags: Br J Dermatol Source Type: research

The optimal regimen of brentuximab vedotin for CD30+ cutaneous lymphoma: Are we there yet?
This article is protected by copyright. All rights reserved. PMID: 29023638 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 10, 2017 Category: Dermatology Authors: Geller S, Myskowski PL, Kim YH, Moskowitz A, Horwitz S Tags: Br J Dermatol Source Type: research

Erythrokeratoderma - a manifestation associated with multiple types of ichthyoses with different gene defects.
This article is protected by copyright. All rights reserved. PMID: 29023646 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 10, 2017 Category: Dermatology Authors: Youssefian L, Touati A, Vahidnezhad H, Saeidian AH, Sotoudeh S, Zeinali S, Uitto J Tags: Br J Dermatol Source Type: research

Epidemiology of keratinocyte carcinomas after organ transplantation.
We describe international variation in KC and focus on trends in immunosuppressive regimens, the role of ultraviolet susceptibility and exposure, and the contribution of genetics to tumour development. Further epidemiological studies are needed to address gaps in our understanding of the mediation of excess KC by immunosuppressive drugs, viral infection, genetic susceptibility, timing of relevant ultraviolet exposure or some combination of these factors. PMID: 28994104 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 10, 2017 Category: Dermatology Authors: Madeleine MM, Patel NS, Plasmeijer EI, Engels EA, Bouwes Bavinck JN, Toland AE, Green AC, the Keratinocyte Carcinoma Consortium (KeraCon) Immunosuppression Working Group Tags: Br J Dermatol Source Type: research

Reply to 'Impact of biologic therapies on risk of major adverse cardiovascular events in patients with psoriasis: systematic review and meta-analysis of randomized controlled trials': reply from the authors.
This article is protected by copyright. All rights reserved. PMID: 28990164 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 9, 2017 Category: Dermatology Authors: Rungapiromnan W, Yiu ZZN, Warren RB, Griffiths CEM, Ashcroft DM Tags: Br J Dermatol Source Type: research

Irradiance, as well as body site and timing of readings, is important in determining ultraviolet A minimal erythemal dose: reply from the authors.
This article is protected by copyright. All rights reserved. PMID: 28990167 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 9, 2017 Category: Dermatology Authors: Gambichler T, Wolf P Tags: Br J Dermatol Source Type: research

The prevalence of psychological co-morbidity in people with vitiligo: a systematic review and meta-analysis.
CONCLUSIONS: A range of psychological outcomes are common in people with vitiligo. The prevalence of anxiety was influenced by type of screening tool, suggesting validation of psychological outcome screening tools in the field of dermatology. This article is protected by copyright. All rights reserved. PMID: 28991357 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 9, 2017 Category: Dermatology Authors: Osinubi O, Grainge MJ, Hong L, Ahmed A, Batchelor JM, Grindlay D, Thompson AR, Ratib S Tags: Br J Dermatol Source Type: research

Low dose naltrexone: a novel treatment for Hailey-Hailey disease.
This article is protected by copyright. All rights reserved. PMID: 28991360 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 9, 2017 Category: Dermatology Authors: Campbell V, McGrath C, Corry A Tags: Br J Dermatol Source Type: research

Ixekizumab treatment for psoriasis: Integrated efficacy analysis of three double-blinded, controlled studies (UNCOVER-1, UNCOVER-2, UNCOVER-3).
Abstract BACKGROUND: Ixekizumab, a high-affinity monoclonal antibody that selectively targets interleukin (IL)-17A, is approved for the treatment of moderate-to-severe psoriasis. OBJECTIVES: This analysis represents an overview of the efficacy outcomes from three Phase 3 psoriasis studies. METHODS: Data were integrated from the 12-week induction period of three studies in which patients received ixekizumab 80 mg every 2 (IXE Q2W; N=1169) or 4 weeks (IXE Q4W; N=1165) after an initial 160-mg dose for both, etanercept (ETN) (50 mg biweekly; N=740; two studies), or placebo (PBO) (N=792). The co-primary endpo...
Source: The British Journal of Dermatology - October 9, 2017 Category: Dermatology Authors: Papp KA, Leonardi CL, Blauvelt A, Reich K, Korman NJ, Ohtsuki M, Paul C, Ball S, Cameron GS, Erickson J, Zhang L, Mallbris L, Griffiths CEM Tags: Br J Dermatol Source Type: research

No Elevated Risk for Depression, Anxiety, or Suicidality with Secukinumab in a Pooled Analysis of Data from 10 Clinical Studies in Moderate-to-Severe Plaque Psoriasis.
This article is protected by copyright. All rights reserved. PMID: 28991372 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 9, 2017 Category: Dermatology Authors: Strober BE, Langley RGB, Menter A, Magid M, Porter B, Fox T, Safi J, Papavassilis C Tags: Br J Dermatol Source Type: research

Neuro-Psychiatric Comorbidity among Psoriatic Adolescents.
CONCLUSION: Psoriasis among adolescents is associated with neuro-psychiatric co-morbidities and impaired adjustment skills, depending on disease severity. This article is protected by copyright. All rights reserved. PMID: 28990159 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 8, 2017 Category: Dermatology Authors: Galili E, Barzilai A, Shreberk-Hassidim R, Merdler I, Caspi T, Astman N Tags: Br J Dermatol Source Type: research

Uncovering the diagnostic dermoscopic features of flat melanomas located on the lower limbs.
This article is protected by copyright. All rights reserved. PMID: 28986968 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 7, 2017 Category: Dermatology Authors: Bassoli S, Kyrgidis A, Ciardo S, Casari A, Losi A, De Pace B, Babino G, De Col E, Marchetti Cautela J, Ferrari F, Moscarella E, Lallas A, Argenziano G, Pellacani G, Longo C Tags: Br J Dermatol Source Type: research

Development of an international core outcome set for peripheral vascular malformations (OVAMA project).
CONCLUSION: It is recommended to measure at least these core outcome domains in therapeutic-efficacy studies on peripheral vascular malformations. This article is protected by copyright. All rights reserved. PMID: 28986976 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 7, 2017 Category: Dermatology Authors: Horbach SER, van der Horst CMAM, Blei F, van der Vleuten CJM, Frieden IJ, Richter GT, Tan ST, Muir T, Penington A, Boon LM, Spuls PI, OVAMA consensus group Tags: Br J Dermatol Source Type: research

IL-36 in hidradenitis suppurativa: Evidence for a distinctive pro-inflammatory role and a key factor in the development of an inflammatory loop.
CONCLUSIONS: Our results showed a possible involvement of IL-36 cytokines in the inflammatory network of HS and a dysbalance between the agonistic and antagonistic cytokines in HS skin. This article is protected by copyright. All rights reserved. PMID: 28975626 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 4, 2017 Category: Dermatology Authors: Hessam S, Sand M, Gambichler T, Skrygan M, Rüddel I, Bechara FG Tags: Br J Dermatol Source Type: research

Pansclerotic morphea associated with hypohidrosis and anti-M3 muscarinic acetylcholine receptor antibodies.
This article is protected by copyright. All rights reserved. PMID: 28977673 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 4, 2017 Category: Dermatology Authors: Fujita-Tanaka H, Ogawa Y, Muro Y, Ogawa-Momohara M, Asashima H, Tsuboi H, Sumida T, Akiyama M Tags: Br J Dermatol Source Type: research