Mycosis fungoides-derived exosomes and their microRNA-1246 cargo: a message from the skin
Br J Dermatol. 2021 Sep 14. doi: 10.1111/bjd.20695. Online ahead of print.NO ABSTRACTPMID:34519031 | DOI:10.1111/bjd.20695 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 14, 2021 Category: Dermatology Authors: I Pospischil E Guenova Source Type: research

Mycosis fungoides-derived exosomes and their microRNA-1246 cargo: a message from the skin
Br J Dermatol. 2021 Sep 14. doi: 10.1111/bjd.20695. Online ahead of print.NO ABSTRACTPMID:34519031 | DOI:10.1111/bjd.20695 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 14, 2021 Category: Dermatology Authors: I Pospischil E Guenova Source Type: research

Mycosis fungoides-derived exosomes and their microRNA-1246 cargo: a message from the skin
Br J Dermatol. 2021 Sep 14. doi: 10.1111/bjd.20695. Online ahead of print.NO ABSTRACTPMID:34519031 | DOI:10.1111/bjd.20695 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 14, 2021 Category: Dermatology Authors: I Pospischil E Guenova Source Type: research

Mycosis fungoides-derived exosomes and their microRNA-1246 cargo: a message from the skin
Br J Dermatol. 2021 Sep 14. doi: 10.1111/bjd.20695. Online ahead of print.NO ABSTRACTPMID:34519031 | DOI:10.1111/bjd.20695 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 14, 2021 Category: Dermatology Authors: I Pospischil E Guenova Source Type: research

Mycosis fungoides-derived exosomes and their microRNA-1246 cargo: a message from the skin
Br J Dermatol. 2021 Sep 14. doi: 10.1111/bjd.20695. Online ahead of print.NO ABSTRACTPMID:34519031 | DOI:10.1111/bjd.20695 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 14, 2021 Category: Dermatology Authors: I Pospischil E Guenova Source Type: research

Combined carboplatin and paclitaxel therapy improves overall survival in patients with nivolumab-resistant acral and mucosal melanoma
Br J Dermatol. 2021 Sep 12. doi: 10.1111/bjd.20758. Online ahead of print.ABSTRACTImmuno-oncology (IO) drugs are an essential treatment option for BRAF wild-type melanoma. However, effective treatment for IO drug-resistant BRAF wild-type melanoma is yet to be established. The proportion of BRAF wild-type melanoma is known to be higher in acral lentiginous melanoma (ALM) and mucosal melanoma (MCM) than in other clinical subtypes.1 Consequently, treatment options other than IO drugs have important implications for these clinical subtypes. Several studies have reported that the response rate (RR) of chemotherapy increases aft...
Source: The British Journal of Dermatology - September 12, 2021 Category: Dermatology Authors: T Maeda A Hiura J Uehara R Toyoshima T Nakagawa K Yoshino Source Type: research

Revealing novel, latent subsets of morphea patients through principal component analysis
Br J Dermatol. 2021 Sep 12. doi: 10.1111/bjd.20748. Online ahead of print.ABSTRACTThe clinical features and patient impact of morphea, an inflammatory disorder of the skin and soft tissue, remain poorly characterized. While numerous clinical classification schemes are in use, there is little work systematically examining latent clinical and quality of life features within these clinical subtypes. In an effort to address this gap, prior work from our group revealed that the Padua Criteria performed best in grouping patients into consistent subtypes, however we did not perform in depth analysis of subsets that may exist with...
Source: The British Journal of Dermatology - September 12, 2021 Category: Dermatology Authors: L F Abbas A K Joseph S Prasad J L Zhu K S Fitch R Haley K S Torok H T Jacobe Source Type: research

Allergic contact dermatitis caused by dipropylene glycol diacrylate in the Omnipod ® insulin pump
CONCLUSIONS: When suspecting ACD to MDs DPGDA at 0.1% in pet. should be tested. The content of Omnipod® has changed over time. Patch testing with updated test series and relevance assessment of positive reactions is a delicate task. Children, with lifelong use of MDs, risk contracting many allergies with potential cross-allergies. A question should be raised - whether these low molecular weight acrylates should at all be used in devices constantly worn on the skin.PMID:34510410 | DOI:10.1111/bjd.20751 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 12, 2021 Category: Dermatology Authors: J Ulriksdotter C Svedman M Bruze M Mowitz Source Type: research

Cause-specific mortality in people with bullous pemphigoid and pemphigus vulgaris: a systematic review & amp; meta-analysis
Br J Dermatol. 2021 Sep 12. doi: 10.1111/bjd.20759. Online ahead of print.ABSTRACTBullous pemphigoid (BP) and pemphigus vulgaris (PV) are autoimmune blistering skin disorders which are increasing in incidence and are associated with high mortality.1,2 As people with BP and PV often have comorbidity and require treatment that has severe side-effects, they could die of various causes.3,4,5 A systematic review on cause-specific mortality in has not previously been conducted. The aim of this study was to examine causes of death in patients with BP and PV.PMID:34510412 | DOI:10.1111/bjd.20759 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 12, 2021 Category: Dermatology Authors: A Hasanaj F Zaki K E Harman D Grindlay S Gran Source Type: research

Clinical translation of hidradenitis suppurativa genetic studies requires global collaboration
Br J Dermatol. 2021 Sep 9. doi: 10.1111/bjd.20749. Online ahead of print.ABSTRACTHidradenitis suppurativa (HS) is a prevalent and debilitating skin disease that arises from pathological inflammation in the hair follicle, particularly those located within the axillae, groin, and buttocks. Disease management is difficult and there are many unmet medical needs. There is a high degree of clinical heterogeneity. HS can be limited to the presentation of prototypical skin lesions for some patients, while for others it presents as a disease with multi-organ or systemic involvement.PMID:34498254 | DOI:10.1111/bjd.20749 (Source: The...
Source: The British Journal of Dermatology - September 9, 2021 Category: Dermatology Authors: A J Jabbour K R van Straalen A Colvin E P Prens L Petukhova Source Type: research

Three Novel Structural Variations at MHC and IL12B Predisposing to Psoriasis
This study aimed to investigate the association of SVs and psoriasis.METHODS: We performed a genome-wide screen on SVs using an imputation method on 5 independent cohorts with 45,386 subjects from the Chinese Han population. Fine mapping analysis, genetic interaction analysis and RNA expression analysis were conducted to explore the mechanism of SVs.RESULTS: We obtained 4,535 SVs in total and identified 2 novel deletions (esv3608550, OR=2.73, P
Source: The British Journal of Dermatology - September 9, 2021 Category: Dermatology Authors: Q Zhen Y Zhang Y Yu H Yang T Zhang X Li X Mo B Li J Wu Y Liang H Ge Q Xu W Chen W Qian H Xu G Chen B Bai J Zhang Y Lu S Chen H Zhang Y Zhang X Chen X Li X Jin X Lin L Yong M Fang J Zhao Y Lu S Wu D Jiang J Shi H Cao Y Qiu S Li X Kang J Shen H Ma S Sun Y F Source Type: research

Antimicrobial Peptides in Hidradenitis Suppurativa - A Systematic Review
Br J Dermatol. 2021 Sep 9. doi: 10.1111/bjd.20750. Online ahead of print.ABSTRACTHidradenitis suppurativa is a chronic, inflammatory skin disease of the hair follicle defined by recurrent nodules, tunnels and scarring involving the intertriginous regions. HS is associated with microbial dysbiosis and immune dysregulation. In HS, an increasing number of studies have investigated antimicrobial peptides (AMPs). A systematic literature search was conducted to identify studies on AMPs in HS. PubMed, EMBASE, and Cochrane Library were searched. All articles were manually screened based on title, abstract, and full text. Additiona...
Source: The British Journal of Dermatology - September 9, 2021 Category: Dermatology Authors: Y Yao J W Frew S F Thomsen H C Ring Source Type: research

Clinical translation of hidradenitis suppurativa genetic studies requires global collaboration
Br J Dermatol. 2021 Sep 9. doi: 10.1111/bjd.20749. Online ahead of print.ABSTRACTHidradenitis suppurativa (HS) is a prevalent and debilitating skin disease that arises from pathological inflammation in the hair follicle, particularly those located within the axillae, groin, and buttocks. Disease management is difficult and there are many unmet medical needs. There is a high degree of clinical heterogeneity. HS can be limited to the presentation of prototypical skin lesions for some patients, while for others it presents as a disease with multi-organ or systemic involvement.PMID:34498254 | DOI:10.1111/bjd.20749 (Source: The...
Source: The British Journal of Dermatology - September 9, 2021 Category: Dermatology Authors: A J Jabbour K R van Straalen A Colvin E P Prens L Petukhova Source Type: research

Three Novel Structural Variations at MHC and IL12B Predisposing to Psoriasis
This study aimed to investigate the association of SVs and psoriasis.METHODS: We performed a genome-wide screen on SVs using an imputation method on 5 independent cohorts with 45,386 subjects from the Chinese Han population. Fine mapping analysis, genetic interaction analysis and RNA expression analysis were conducted to explore the mechanism of SVs.RESULTS: We obtained 4,535 SVs in total and identified 2 novel deletions (esv3608550, OR=2.73, P
Source: The British Journal of Dermatology - September 9, 2021 Category: Dermatology Authors: Q Zhen Y Zhang Y Yu H Yang T Zhang X Li X Mo B Li J Wu Y Liang H Ge Q Xu W Chen W Qian H Xu G Chen B Bai J Zhang Y Lu S Chen H Zhang Y Zhang X Chen X Li X Jin X Lin L Yong M Fang J Zhao Y Lu S Wu D Jiang J Shi H Cao Y Qiu S Li X Kang J Shen H Ma S Sun Y F Source Type: research

Antimicrobial Peptides in Hidradenitis Suppurativa - A Systematic Review
Br J Dermatol. 2021 Sep 9. doi: 10.1111/bjd.20750. Online ahead of print.ABSTRACTHidradenitis suppurativa is a chronic, inflammatory skin disease of the hair follicle defined by recurrent nodules, tunnels and scarring involving the intertriginous regions. HS is associated with microbial dysbiosis and immune dysregulation. In HS, an increasing number of studies have investigated antimicrobial peptides (AMPs). A systematic literature search was conducted to identify studies on AMPs in HS. PubMed, EMBASE, and Cochrane Library were searched. All articles were manually screened based on title, abstract, and full text. Additiona...
Source: The British Journal of Dermatology - September 9, 2021 Category: Dermatology Authors: Y Yao J W Frew S F Thomsen H C Ring Source Type: research

Clinical translation of hidradenitis suppurativa genetic studies requires global collaboration
Br J Dermatol. 2021 Sep 9. doi: 10.1111/bjd.20749. Online ahead of print.ABSTRACTHidradenitis suppurativa (HS) is a prevalent and debilitating skin disease that arises from pathological inflammation in the hair follicle, particularly those located within the axillae, groin, and buttocks. Disease management is difficult and there are many unmet medical needs. There is a high degree of clinical heterogeneity. HS can be limited to the presentation of prototypical skin lesions for some patients, while for others it presents as a disease with multi-organ or systemic involvement.PMID:34498254 | DOI:10.1111/bjd.20749 (Source: The...
Source: The British Journal of Dermatology - September 9, 2021 Category: Dermatology Authors: A J Jabbour K R van Straalen A Colvin E P Prens L Petukhova Source Type: research

Three Novel Structural Variations at MHC and IL12B Predisposing to Psoriasis
This study aimed to investigate the association of SVs and psoriasis.METHODS: We performed a genome-wide screen on SVs using an imputation method on 5 independent cohorts with 45,386 subjects from the Chinese Han population. Fine mapping analysis, genetic interaction analysis and RNA expression analysis were conducted to explore the mechanism of SVs.RESULTS: We obtained 4,535 SVs in total and identified 2 novel deletions (esv3608550, OR=2.73, P
Source: The British Journal of Dermatology - September 9, 2021 Category: Dermatology Authors: Q Zhen Y Zhang Y Yu H Yang T Zhang X Li X Mo B Li J Wu Y Liang H Ge Q Xu W Chen W Qian H Xu G Chen B Bai J Zhang Y Lu S Chen H Zhang Y Zhang X Chen X Li X Jin X Lin L Yong M Fang J Zhao Y Lu S Wu D Jiang J Shi H Cao Y Qiu S Li X Kang J Shen H Ma S Sun Y F Source Type: research

Antimicrobial Peptides in Hidradenitis Suppurativa - A Systematic Review
Br J Dermatol. 2021 Sep 9. doi: 10.1111/bjd.20750. Online ahead of print.ABSTRACTHidradenitis suppurativa is a chronic, inflammatory skin disease of the hair follicle defined by recurrent nodules, tunnels and scarring involving the intertriginous regions. HS is associated with microbial dysbiosis and immune dysregulation. In HS, an increasing number of studies have investigated antimicrobial peptides (AMPs). A systematic literature search was conducted to identify studies on AMPs in HS. PubMed, EMBASE, and Cochrane Library were searched. All articles were manually screened based on title, abstract, and full text. Additiona...
Source: The British Journal of Dermatology - September 9, 2021 Category: Dermatology Authors: Y Yao J W Frew S F Thomsen H C Ring Source Type: research

Image: Atypical chondrodermatitis nodularis due to in-ear headphones
Br J Dermatol. 2021 Sep 8. doi: 10.1111/bjd.20702. Online ahead of print.NO ABSTRACTPMID:34496030 | DOI:10.1111/bjd.20702 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 8, 2021 Category: Dermatology Authors: C Huffman M A Cardis Source Type: research

PPAR γ signaling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial-mesenchymal transition
CONCLUSIONS: A cyclophosphamide metabolite alone suffices to damage and deplete human scalp eHFSCs by promoting apoptosis, DNA damage, and EMT ex vivo. Therefore, pCIA-therapeutic strategies need to target these pathological processes. Our data introduce the stimulation of PPARγ signaling as a novel intervention strategy for the prevention of pCIA, given the ability of NAGED to prevent chemotherapy-induced eHFSCs damage ex vivo.PMID:34496034 | DOI:10.1111/bjd.20745 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 8, 2021 Category: Dermatology Authors: I Piccini L Brunken J Ch éret S Ghatak Y Ramot M Alam T S Purba J Hardman H Erdmann F Jimenez R Paus M Bertolini Source Type: research

Underreporting of race and ethnicity in pediatric atopic dermatitis clinical trials: A cross-sectional analysis of demographic reporting and representation
Br J Dermatol. 2021 Sep 4. doi: 10.1111/bjd.20740. Online ahead of print.ABSTRACTWhile the importance of pediatric clinical trials is undeniable, there is a relative paucity of safety/efficacy data for medicines used in children. Differences in physiology and pharmacology must be investigated in clinical trials to understand the unique adverse outcomes experienced by children versus adults. Furthermore, underrepresentation of females/minority groups is a well-documented issue in dermatological clinical trials.PMID:34480338 | DOI:10.1111/bjd.20740 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 4, 2021 Category: Dermatology Authors: J Ding M Joseph N Yau F Khosa Source Type: research

A retrospective case series of paediatric Stevens-Johnson syndrome and toxic epidermal necrolysis: evaluation of practice using the British Association of Dermatology's National Guidelines for children and young people
Br J Dermatol. 2021 Sep 4. doi: 10.1111/bjd.20741. Online ahead of print.ABSTRACTThe recent publication of the first national guidelines for paediatric Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in your journal is a valuable step towards building a focussed understanding of paediatric SJS/TEN (1). The recommended audit points are essential for facilitating a national standard of care.PMID:34480344 | DOI:10.1111/bjd.20741 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 4, 2021 Category: Dermatology Authors: J R Forsyth E Russell T McPherson Source Type: research

Clinical characteristics of male frontal fibrosing alopecia: A single-centre case series from London, United Kingdom
Br J Dermatol. 2021 Sep 4. doi: 10.1111/bjd.20742. Online ahead of print.ABSTRACTFrontal fibrosing alopecia (FFA) is a variant of lichen planopilaris (LPP) characterised primarily by inflammation and irreversible hair loss affecting the frontotemporal scalp. Expert consensus now suggests that FFA incidence is increasing and this has led to increased interest in its aetiopathogenesis. As FFA disproportionately affects post-menopausal women, our group previously assessed genotype-phenotype correlation in FFA, phenotyping a large female FFA cohort and demonstrating a causal role for genetic variants implicated in xenobiotic m...
Source: The British Journal of Dermatology - September 4, 2021 Category: Dermatology Authors: T Rayinda S M McSweeney N Dand D A Fenton J A McGrath C Tziotzios Source Type: research

The global incidence of bullous pemphigoid: a systematic review and meta-analysis
Br J Dermatol. 2021 Sep 4. doi: 10.1111/bjd.20743. Online ahead of print.ABSTRACTBullous pemphigoid is an autoimmune blistering disorder that mainly affects older people. Although the disease is associated with considerable morbidity and mortality, the burden of disease worldwide is unclear. The study aim is to pool the global incidence of bullous pemphigoid and determine whether this varies according to geographic area, age group, setting, and study quality. Ovid Embase, MEDLINE, and grey literature were systematically searched on 7th April 2020. Two reviewers independently screened, extracted data, and appraised each stu...
Source: The British Journal of Dermatology - September 4, 2021 Category: Dermatology Authors: M S M Persson N Begum M J Grainge K E Harman D Grindlay S Gran Source Type: research

Identifying the best predictive diagnostic criteria for psoriasis in children ( & lt;18 years): A UK multicenter case-control diagnostic accuracy study (DIPSOC study)
Br J Dermatol. 2021 Sep 3. doi: 10.1111/bjd.20689. Online ahead of print.ABSTRACTBACKGROUND: In children, psoriasis can be challenging to diagnose. Difficulties arise from differences in the clinical presentation compared to adults.OBJECTIVES: To test the diagnostic accuracy of previously agreed consensus criteria and develop a shortlist of best predictive diagnostic criteria for childhood psoriasis.METHODS: A case-control diagnostic accuracy study in 12 UK dermatology departments (2017-2019) assessed 18 clinical criteria using blinded trained investigators. Children (
Source: The British Journal of Dermatology - September 3, 2021 Category: Dermatology Authors: E Burden-The R Murphy S Gran T Nijsten C Hughes A Abdul-Wahab A Bewley N Burrows S Darne J E Gach R Katugampola C S Jury K Kuet J Llewellyn T McPherson J C Ravenscroft S Taibjee C Wilkinson K S Thomas Source Type: research

Commentary on the British Association of Dermatologists UK basal cell carcinoma guidelines 2021: all together now …
Br J Dermatol. 2021 Sep 2. doi: 10.1111/bjd.20694. Online ahead of print.NO ABSTRACTPMID:34472089 | DOI:10.1111/bjd.20694 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 2, 2021 Category: Dermatology Authors: M D Moncrieff J P Nobes Source Type: research

19th Congress - European Society for Dermatology and Psychiatry (ESDaP) & amp; 2nd Brain Skin Colloquium Conference. 11 < sup > th < /sup > - 12 < sup > th < /sup > June 2021
Br J Dermatol. 2021 Sep;185(3):e70-e156. doi: 10.1111/bjd.20518.NO ABSTRACTPMID:34472631 | DOI:10.1111/bjd.20518 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 2, 2021 Category: Dermatology Source Type: research

The essential role of dermatology publications in enhancing professional diversity, equity and inclusion
Br J Dermatol. 2021 Sep;185(3):473-474. doi: 10.1111/bjd.20473.NO ABSTRACTPMID:34472633 | DOI:10.1111/bjd.20473 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 2, 2021 Category: Dermatology Authors: S Burgin N C Dlova J R Ingram L C Parish L A Goldsmith Source Type: research

Corrigendum
Br J Dermatol. 2021 Sep;185(3):686. doi: 10.1111/bjd.20649.NO ABSTRACTPMID:34472635 | DOI:10.1111/bjd.20649 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 2, 2021 Category: Dermatology Source Type: research

Corrigendum
Br J Dermatol. 2021 Sep;185(3):685. doi: 10.1111/bjd.20562.NO ABSTRACTPMID:34472636 | DOI:10.1111/bjd.20562 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 2, 2021 Category: Dermatology Source Type: research

Corrigendum
Br J Dermatol. 2021 Sep;185(3):685. doi: 10.1111/bjd.20561.NO ABSTRACTPMID:34472637 | DOI:10.1111/bjd.20561 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 2, 2021 Category: Dermatology Source Type: research

More than skin deep: a survey of the real-life experiences of acne vulgaris
Br J Dermatol. 2021 Sep 2. doi: 10.1111/bjd.20737. Online ahead of print.ABSTRACTAcne vulgaris is the most common inflammatory dermatosis treated worldwide.1 Acne typically affects younger age groups during a time of physical and social transitions. Acne is often considered a non-serious condition and can be overlooked by medical professionals.2 Recent studies have highlighted the importance of assessing the psychosocial aspect of dermatological conditions to intervene early, provide the necessary psychological support and help prevent suicide.PMID:34473341 | DOI:10.1111/bjd.20737 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 2, 2021 Category: Dermatology Authors: A G Ra B Ho L Bickerstaffe A Bewley Source Type: research

A national audit of oral propranolol for the treatment of Infantile Hemangiomas
Br J Dermatol. 2021 Sep 2. doi: 10.1111/bjd.20738. Online ahead of print.ABSTRACTInfantile haemangiomas (IH) affect up to 4% of infants and are the most common tumour of infancy. Although self-limiting, some lesions can lead to visual impairment, airway obstruction, ulceration or cosmetic disfigurement and require intervention. Oral propranolol, a nonselective beta-blocker was serendipitously identified as an effective treatment of IH in 2008 and is now recommended as first-line therapy for complicated lesions.PMID:34473344 | DOI:10.1111/bjd.20738 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 2, 2021 Category: Dermatology Authors: C Cotter L Solman C Flohr Source Type: research

Hidradenitis suppurativa: redirecting a life trajectory
Br J Dermatol. 2021 Sep 1. doi: 10.1111/bjd.20696. Online ahead of print.NO ABSTRACTPMID:34468981 | DOI:10.1111/bjd.20696 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2021 Category: Dermatology Authors: J Hsiao V Shi Source Type: research

Another step on the road towards standardized outcome reporting for congenital melanocytic naevi: one more to go!
Br J Dermatol. 2021 Sep 1. doi: 10.1111/bjd.20691. Online ahead of print.NO ABSTRACTPMID:34468984 | DOI:10.1111/bjd.20691 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2021 Category: Dermatology Authors: M V Heppt T Steeb C Berking Source Type: research

Stratified psoriasis treatment plans: why is patient preference information needed?
Br J Dermatol. 2021 Aug 31. doi: 10.1111/bjd.20697. Online ahead of print.NO ABSTRACTPMID:34463961 | DOI:10.1111/bjd.20697 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 31, 2021 Category: Dermatology Authors: J M Gonzalez S D Reed F R Johnson Source Type: research

Decoding the pharmacogenetics of nonsteroidal anti-inflammatory drug hypersensitivity
Br J Dermatol. 2021 Aug 30. doi: 10.1111/bjd.20693. Online ahead of print.NO ABSTRACTPMID:34459498 | DOI:10.1111/bjd.20693 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 30, 2021 Category: Dermatology Authors: C Flores Source Type: research

Decoding the pharmacogenetics of nonsteroidal anti-inflammatory drug hypersensitivity
Br J Dermatol. 2021 Aug 30. doi: 10.1111/bjd.20693. Online ahead of print.NO ABSTRACTPMID:34459498 | DOI:10.1111/bjd.20693 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 30, 2021 Category: Dermatology Authors: C Flores Source Type: research

New insights on ocular surface disease in atopic dermatitis patients treated with dupilumab
Br J Dermatol. 2021 Aug 25. doi: 10.1111/bjd.20706. Online ahead of print.ABSTRACTDupilumab was approved by the Food and Drug Administration and European Medicine Agency in 2017 for use in adults with moderate-to-severe atopic dermatitis (AD) [1]. One of the most commonly reported adverse events of dupilumab is ocular surface disease, initially termed "conjunctivitis" in clinical trials [2]. A more appropriate definition is dupilumab-induced ocular surface disease (DIOSD), first proposed by Zirwas [3]. Typical symptoms of DIOSD include tearing, foreign body sensation, burning sensation, itching and photophobia [1...
Source: The British Journal of Dermatology - August 25, 2021 Category: Dermatology Authors: P Bortoluzzi S Ferrucci D Galimberti F Garavelli F Pozzo Giuffrida A Pizzati A V Marzano C Mapelli Source Type: research

New insights on ocular surface disease in atopic dermatitis patients treated with dupilumab
Br J Dermatol. 2021 Aug 25. doi: 10.1111/bjd.20706. Online ahead of print.ABSTRACTDupilumab was approved by the Food and Drug Administration and European Medicine Agency in 2017 for use in adults with moderate-to-severe atopic dermatitis (AD) [1]. One of the most commonly reported adverse events of dupilumab is ocular surface disease, initially termed "conjunctivitis" in clinical trials [2]. A more appropriate definition is dupilumab-induced ocular surface disease (DIOSD), first proposed by Zirwas [3]. Typical symptoms of DIOSD include tearing, foreign body sensation, burning sensation, itching and photophobia [1...
Source: The British Journal of Dermatology - August 25, 2021 Category: Dermatology Authors: P Bortoluzzi S Ferrucci D Galimberti F Garavelli F Pozzo Giuffrida A Pizzati A V Marzano C Mapelli Source Type: research

New insights on ocular surface disease in atopic dermatitis patients treated with dupilumab
Br J Dermatol. 2021 Aug 25. doi: 10.1111/bjd.20706. Online ahead of print.ABSTRACTDupilumab was approved by the Food and Drug Administration and European Medicine Agency in 2017 for use in adults with moderate-to-severe atopic dermatitis (AD) [1]. One of the most commonly reported adverse events of dupilumab is ocular surface disease, initially termed "conjunctivitis" in clinical trials [2]. A more appropriate definition is dupilumab-induced ocular surface disease (DIOSD), first proposed by Zirwas [3]. Typical symptoms of DIOSD include tearing, foreign body sensation, burning sensation, itching and photophobia [1...
Source: The British Journal of Dermatology - August 25, 2021 Category: Dermatology Authors: P Bortoluzzi S Ferrucci D Galimberti F Garavelli F Pozzo Giuffrida A Pizzati A V Marzano C Mapelli Source Type: research

New insights on ocular surface disease in atopic dermatitis patients treated with dupilumab
Br J Dermatol. 2021 Aug 25. doi: 10.1111/bjd.20706. Online ahead of print.ABSTRACTDupilumab was approved by the Food and Drug Administration and European Medicine Agency in 2017 for use in adults with moderate-to-severe atopic dermatitis (AD) [1]. One of the most commonly reported adverse events of dupilumab is ocular surface disease, initially termed "conjunctivitis" in clinical trials [2]. A more appropriate definition is dupilumab-induced ocular surface disease (DIOSD), first proposed by Zirwas [3]. Typical symptoms of DIOSD include tearing, foreign body sensation, burning sensation, itching and photophobia [1...
Source: The British Journal of Dermatology - August 25, 2021 Category: Dermatology Authors: P Bortoluzzi S Ferrucci D Galimberti F Garavelli F Pozzo Giuffrida A Pizzati A V Marzano C Mapelli Source Type: research

New insights on ocular surface disease in atopic dermatitis patients treated with dupilumab
Br J Dermatol. 2021 Aug 25. doi: 10.1111/bjd.20706. Online ahead of print.ABSTRACTDupilumab was approved by the Food and Drug Administration and European Medicine Agency in 2017 for use in adults with moderate-to-severe atopic dermatitis (AD) [1]. One of the most commonly reported adverse events of dupilumab is ocular surface disease, initially termed "conjunctivitis" in clinical trials [2]. A more appropriate definition is dupilumab-induced ocular surface disease (DIOSD), first proposed by Zirwas [3]. Typical symptoms of DIOSD include tearing, foreign body sensation, burning sensation, itching and photophobia [1...
Source: The British Journal of Dermatology - August 25, 2021 Category: Dermatology Authors: P Bortoluzzi S Ferrucci D Galimberti F Garavelli F Pozzo Giuffrida A Pizzati A V Marzano C Mapelli Source Type: research

Mogamulizumab Efficacy is Underscored by its Associated Rash that Mimics Cutaneous T-cell Lymphoma: A Retrospective Single-Centre Case Series
CONCLUSIONS: MAR has the potential to create a significant management problem for patients on mogamulizumab. Misidentification of MAR as recurrent CTCL may detrimentally result in the premature discontinuation of mogamulizumab in patients whose disease is historically hard to treat. Thorough clinicopathologic investigation of new lesions during treatment with mogamulizumab is required to inform ideal treatment decisions and achieve better outcomes.PMID:34427917 | DOI:10.1111/bjd.20708 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 24, 2021 Category: Dermatology Authors: N A Trum J Zain X U Martinez V Parekh M Afkhami F Abdulla K R Carson S T Rosen C L Bennett C Querfeld Source Type: research

Not relevant responses in the era of Covid-19 - are we underestimating dermatology life quality index values?
Br J Dermatol. 2021 Aug 24. doi: 10.1111/bjd.20705. Online ahead of print.ABSTRACTSince March 2020, the UK and Ireland entered a series of lockdowns in the wake of the coronavirus pandemic with restrictions resulting in the closure of non-essential retail, hospitality and sports with employees encouraged to work from home1,2 . Patients on biologic and systemic immunosuppression often restricted their lifestyles more than the general public3 . The Dermatology Life Quality Index (DLQI) is a measure of health-related quality of life used to guide treatment decisions and is an important component of data collected for clinical...
Source: The British Journal of Dermatology - August 24, 2021 Category: Dermatology Authors: N Kearney R Hambly A Alsharqi B Kirby Source Type: research

GUIDEMAP: an open-access dermatology guidelines repository
Br J Dermatol. 2021 Aug 18. doi: 10.1111/bjd.20652. Online ahead of print.NO ABSTRACTPMID:34409586 | DOI:10.1111/bjd.20652 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 19, 2021 Category: Dermatology Authors: T E Sivesind R P Dellavalle Source Type: research

Anakinra for palmoplantar pustulosis: results from a randomized, double-blind, multicentre, two staged, adaptive placebo controlled trial (APRICOT)
CONCLUSIONS: No evidence for superiority of anakinra was found. IL-1 blockade is not a useful intervention for the treatment of PPP.PMID:34411292 | DOI:10.1111/bjd.20653 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 19, 2021 Category: Dermatology Authors: S Cro V R Cornelius A E Pink R Wilson A Pushpa-Rajah P Patel A Abdul-Wahab S August J Azad G Becher A Chapman G Dunnil A D Ferguson A Fogo S A Ghaffar J R Ingram S Kavakleiva E Ladoyanni J A Leman A E Macbeth A Makrygeoegou R Parslew A J Ryan A Sharma A R Source Type: research

GUIDEMAP: an open-access dermatology guidelines repository
Br J Dermatol. 2021 Aug 18. doi: 10.1111/bjd.20652. Online ahead of print.NO ABSTRACTPMID:34409586 | DOI:10.1111/bjd.20652 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 19, 2021 Category: Dermatology Authors: T E Sivesind R P Dellavalle Source Type: research

Anakinra for palmoplantar pustulosis: results from a randomized, double-blind, multicentre, two staged, adaptive placebo controlled trial (APRICOT)
CONCLUSIONS: No evidence for superiority of anakinra was found. IL-1 blockade is not a useful intervention for the treatment of PPP.PMID:34411292 | DOI:10.1111/bjd.20653 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 19, 2021 Category: Dermatology Authors: S Cro V R Cornelius A E Pink R Wilson A Pushpa-Rajah P Patel A Abdul-Wahab S August J Azad G Becher A Chapman G Dunnil A D Ferguson A Fogo S A Ghaffar J R Ingram S Kavakleiva E Ladoyanni J A Leman A E Macbeth A Makrygeoegou R Parslew A J Ryan A Sharma A R Source Type: research

GUIDEMAP: an open-access dermatology guidelines repository
Br J Dermatol. 2021 Aug 18. doi: 10.1111/bjd.20652. Online ahead of print.NO ABSTRACTPMID:34409586 | DOI:10.1111/bjd.20652 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 19, 2021 Category: Dermatology Authors: T E Sivesind R P Dellavalle Source Type: research