Interventions for chronic palmoplantar pustulosis: abridged Cochrane systematic review and GRADE assessments.
CONCLUSIONS: Evidence is lacking for or against major chronic PPP treatments. Risk of bias and imprecision limit our confidence in the results. PMID: 32961599 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 22, 2020 Category: Dermatology Authors: Obeid G, Do G, Kirby L, Hughes C, Sbidian E, Le Cleach L Tags: Br J Dermatol Source Type: research

The science and rationale of arriving at the correct drug & dosimetry of griseofulvin, fluconazole, terbinafine, and itraconazole in superficial dermatophyte infections: an important step before a pragmatic trial.
The science and rationale of arriving at the correct drug & dosimetry of griseofulvin, fluconazole, terbinafine, and itraconazole in superficial dermatophyte infections: an important step before a pragmatic trial. Br J Dermatol. 2020 Sep 21;: Authors: Sardana K, Mathachan SR Abstract While India faces the issue of recalcitrant dermatophytosis1 , we would like to focus on the scientific rationale of drug dosimetry based on background microbiological data & existential serum/skin level data (Figure 1) that should predate a clinical trial2 . The first step is based on the minimum inhibitory conce...
Source: The British Journal of Dermatology - September 21, 2020 Category: Dermatology Authors: Sardana K, Mathachan SR Tags: Br J Dermatol Source Type: research

The global burden of chronic urticaria for the patient and society.
L, Weller K, Maurer M Abstract Chronic urticaria (CU) affects about 1% of the world population of all ages, mostly young/middle-aged females, usually lasts for several years (>1 year in 25-75% of patients), and often takes>1 year before effective management is implemented. It presents as chronic spontaneous urticaria (CSU), chronic inducible urticaria (CIndU) or both in the same person. More than 25% of cases are resistant to H1-antihistamines, even at higher doses, and 3rd and 4th line therapy (omalizumab and ciclosporin) control the disease only in two thirds of H1 -antihistamine resistant patients. Here, ...
Source: The British Journal of Dermatology - September 21, 2020 Category: Dermatology Authors: Gonçalo M, Gimenéz-Arnau A, Al-Ahmad M, Ben-Shoshan M, Bernstein JA, Ensina LF, Fomina D, Galvàn CA, Godse K, Grattan C, Hide M, Katelaris CH, Khoshkhui M, Kocatürk E, Kulthanan K, Medina I, Nasr I, Peter J, Staubach P, Wang L, Weller K, Maurer M Tags: Br J Dermatol Source Type: research

Long-term efficacy of certolizumab pegol for psoriasis.
PMID: 32951203 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 20, 2020 Category: Dermatology Authors: Johnson MC, Heron CE, Feldman SR Tags: Br J Dermatol Source Type: research

Early life regulation of inflammation in atopic dermatitis by microRNA.
PMID: 32951210 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 20, 2020 Category: Dermatology Authors: Polak ME Tags: Br J Dermatol Source Type: research

Efficacy and safety of ixekizumab after switching from fumaric acid esters or methotrexate in patients with moderate-to-severe plaque psoriasis na ïve to systemic treatment.
Efficacy and safety of ixekizumab after switching from fumaric acid esters or methotrexate in patients with moderate-to-severe plaque psoriasis naïve to systemic treatment. Br J Dermatol. 2020 Sep 17;: Authors: Leutz A, Pinter A, Thaçi D, Augustin M, Schuster C, Fotiou K, Hundemer HP, Saure D, Mrowietz U, Reich K Abstract Psoriasis is a chronic inflammatory skin disorder, which, in cases of moderate-to-severe disease, requires long-term systemic therapy.1 For patients with an inadequate response or intolerance to a specific systemic therapy, switching psoriasis treatments is a common pract...
Source: The British Journal of Dermatology - September 17, 2020 Category: Dermatology Authors: Leutz A, Pinter A, Thaçi D, Augustin M, Schuster C, Fotiou K, Hundemer HP, Saure D, Mrowietz U, Reich K Tags: Br J Dermatol Source Type: research

Efficacy of topical ropivacaine in children and young adults with hereditary Epidermolysis Bullosa.
Abstract Epidermolysis bullosa (EB) is a heterogeneous group of rare inherited skin disorders that cause fragile, blistering skin.There are 4 major types: EB simplex (EBS), junctional EB (JEB) dystrophic EB (DEB) and Kindler EB1 . The chronic wounds cause severe pain and a major alteration of quality of life. PMID: 32939751 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 16, 2020 Category: Dermatology Authors: Moreno Artero E, Schinkel N, Chaumon S, Corset I, Rabeony T, Elie C, Bellon N, Bodemer C, Greco C Tags: Br J Dermatol Source Type: research

A novel non-drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivo.
aus R Abstract Wnt signalling is one of the most fundamental molecular pathways for modulating the human hair cycle and is essential for maintaining hair growth1 . We recently identified that the Wnt antagonist, secreted frizzled related protein 1 (SFRP1), prematurely induces catagen in microdissected human scalp hair follicles (HFs) ex vivo1 . SFRP1 is inhibited by the potent hypertrichosis inducing immunosuppressant, cyclosporine A (CsA)2 , and the specific SFRP1 antagonist, WAY-316606, both of which prevent spontaneous catagen development1 . PMID: 32939777 [PubMed - as supplied by publisher] (Source: The B...
Source: The British Journal of Dermatology - September 16, 2020 Category: Dermatology Authors: Bertolini M, Chéret J, Pinto D, Hawkshaw N, Ponce L, Erdmann H, Jimenez F, Funk W, Paus R Tags: Br J Dermatol Source Type: research

Development of a Pathogenesis-Based Therapy for Peeling Skin Syndrome Type 1.
CONCLUSION: The study presents the first preclinical in vitro experiments for a future specific protein replacement therapy for patients suffering from PSS1. PMID: 32926582 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 14, 2020 Category: Dermatology Authors: Valentin F, Wiegmann H, Tarinski T, Nikolenko H, Traupe H, Liebau E, Dathe M, Oji V Tags: Br J Dermatol Source Type: research

Evaluation of Malignancy Risk in Scleroderma by Antibody Profile.
Abstract An increased risk of malignancy in systemic sclerosis (SSc) has been reported.1 Moreover, a close temporal relationship between onset of SSc and malignancy has been reported in patients with anti-RNA polymerase III antibody.2 We conducted this study to add to the available data on types and rates of malignancy and to evaluate if our SSc population showed an association between cancer and SSc onset and whether this risk was different in different SSc-specific autoantibody groups. PMID: 32920853 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 13, 2020 Category: Dermatology Authors: Lertphanichkul C, Smith GP Tags: Br J Dermatol Source Type: research

An economic evaluation of the randomised controlled trial of topical corticosteroid and home-based narrowband UVB for active and limited vitiligo (The HI-Light Trial).
gboli M, Stainforth J, Ferguson A, Laguda B, Wahie S, Ellis R, Azad J, Rajasekaran A, Eleftheriadou V, Montgomery AA, UK Dermatology Clinical Trials Network’s HI-LIGHT Vitiligo Trial Team Abstract BACKGROUND: Economic evidence for vitiligo treatments is absent. OBJECTIVE: To determine the cost-effectiveness of (a) hand-held narrowband-UVB (NB-UVB) and (b) combination of topical corticosteroid (TCS) and NB-UVB compared to TCS for localised vitiligo. METHODS: Cost-effectiveness analysis alongside a pragmatic, 3-arm, placebo-controlled RCT with 9 months' treatment. 517 Adults and children (aged ≥5 ...
Source: The British Journal of Dermatology - September 12, 2020 Category: Dermatology Authors: Sach TH, Thomas KS, Batchelor JM, Akram P, Chalmers JR, Haines RH, Meakin GD, Duley L, Ravenscroft JC, Rogers A, Santer M, Tan W, White J, Whitton ME, Williams HC, Cheung ST, Hamad H, Wright A, Ingram JR, Levell N, Goulding JMR, Makrygeorgou A, Bewley A, Tags: Br J Dermatol Source Type: research

A Call to Standardise the BCC:SCC Ratio.
Abstract Basal cell carcinoma (BCC) followed by squamous cell carcinoma (SCC) are the two commonest cancers in white populations worldwide.1 While sharing some features, they are distinct clinically and pathologically and thus the ratio of BCC to SCC incidence rates serves as a useful composite that enables immediate comparisons of trends within and between populations. There is a widely held belief that the BCC:SCC ratio sits relatively constantly at around 4:1 in the general population, though this belief has little apparent basis. PMID: 32920840 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 12, 2020 Category: Dermatology Authors: Jiyad Z, Marquart L, Green AC Tags: Br J Dermatol Source Type: research

What determines the treatment persistence in paediatric psoriasis?
PMID: 32909247 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 10, 2020 Category: Dermatology Authors: Salman A Tags: Br J Dermatol Source Type: research

Genotypic and Phenotypic Analysis of 34 Cases of Inherited Junctional Epidermolysis Bullosa caused by COL17A1 Mutations.
We report 34 JEB patients with COL17A1 genetic mutations diagnosed in our Center between 1993 and 2019. Medical and biological records were collected with a standardized questionnaire. PMID: 32911566 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 10, 2020 Category: Dermatology Authors: Charlesworth A, Hérissé AL, Bellon N, Leclerc-Mercier S, Bourrat E, Hadj-Rabia S, Bodemer C, Lacour JP, Chiaverini C Tags: Br J Dermatol Source Type: research

Identifying key components and therapeutic targets of the immune system in hidradenitis suppurativa with an emphasis on neutrophils.
Abstract Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, and debilitating skin disease of the hair follicle unit that typically develops after puberty. The disorder is characterized by comedones, painful inflammatory nodules, abscesses, dermal tunnels, and scarring, with a predilection for intertriginous areas of the body (axillae, inguinal, and anogenital regions). Recruitment of neutrophils to HS lesion sites may play an essential role in the development of the painful inflammatory nodules and abscesses that characterize the disease. This is a review of the major mediators involved in the re...
Source: The British Journal of Dermatology - September 7, 2020 Category: Dermatology Authors: Narla S, Azzam M, Townsend S, Vellaichamy G, Marzano AV, Alavi A, Lowes MA, Hamzavi IH Tags: Br J Dermatol Source Type: research

Comorbid acne inversa and Dowling-Degos disease due to a single NCSTN mutation - is there enough evidence?
k J Abstract In their recent publication in the Br J Dermatol, Garcovich et al. suggested that a nonsense mutation in the NCSTN (Nicastrin) gene, R583*, would underlie comorbid familial acne inversa (FAI; synonym: familial hidradenitis suppurativa) and Dowling-Degos disease (DDD) in a 54-year old patient [1]. PMID: 32894577 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 7, 2020 Category: Dermatology Authors: Hermasch MA, Schön MP, Frank J Tags: Br J Dermatol Source Type: research

Patterns of cutaneous immune-related adverse events in adults and children with advanced sarcoma: A retrospective cohort study.
Abstract Immune checkpoint inhibitors (ICIs) have improved survival for multiple malignancies in adults and children.1,2 However, their benefits are tempered by a range of serious immune-related adverse events (irAEs). 1,2 Among these, cutaneous irAEs (cirAEs) represent one of the most common subtypes, impacting approximately one-third of adult patients receiving ICIs.1,3 The patterns and significance of cirAEs in children remain unclear, largely because these reactions have not been evaluated in detail. PMID: 32894776 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 7, 2020 Category: Dermatology Authors: Thompson LL, Chang MS, McCormack L, Polyakov N, Yoon J, Song H, Huang JT, Chen ST Tags: Br J Dermatol Source Type: research

Comorbid acne inversa and Dowling-Degos disease due to a single NCSTN mutation - is there enough evidence?: reply from the authors.
Abstract we thank Hermasch et al. for their comments on our paper describing the novel NCSTN R583* mutation associated to familial acne inversa (FAI) in an Italian family, where the proband was also clinically diagnosed with Dowling-Degos disease (DDD). In our report, we raised the attention on this particular patient subset with comorbid FAI-DDD, emphasizing the connection between autoinflammatory-keratinization disorders and genetic reticulated pigmentary disorders. Based on our findings, we think that there ais enough evidence to claim that R583* NCSTN mutation is associated with DDD and FAI. PMID: 3289592...
Source: The British Journal of Dermatology - September 7, 2020 Category: Dermatology Authors: Garcovich S, Tricarico PM, Meddour CN, Giovanardi G, Peris K, Crovella S, Boniotto M Tags: Br J Dermatol Source Type: research

Ruptured hair follicles of the scalp mimicking malignant melanoma.
PMID: 32892340 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 6, 2020 Category: Dermatology Authors: Elsarafy S, Tobiss H, Veitch D, Bhuchar M, Khan M, Patel A Tags: Br J Dermatol Source Type: research

Light in the dark: distinct effects of dimethyl fumarate on different T-cell subsets in psoriasis treatment.
PMID: 32892342 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 6, 2020 Category: Dermatology Authors: Mostafa A, Murata T, Kabashima K Tags: Br J Dermatol Source Type: research

Infantile bullous pemphigoid following serogroup B meningococcal vaccination.
Linares-Barrios M PMID: 32892343 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 6, 2020 Category: Dermatology Authors: Navarro-Navarro I, Jiménez-Gallo D, Valenzuela-Ubiña S, Domínguez-Gomez M, Linares-Barrios M Tags: Br J Dermatol Source Type: research

There is still a place for tumour-targeted therapies in Merkel cell carcinoma in the era of immune checkpoint inhibitors.
PMID: 32892361 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 6, 2020 Category: Dermatology Authors: Samimi M, Becker J Tags: Br J Dermatol Source Type: research

Tocilizumab and other targeted therapies for severe cutaneous immune-related adverse events.
PMID: 32892364 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 6, 2020 Category: Dermatology Authors: Thompson LL, Chen ST Tags: Br J Dermatol Source Type: research

Characteristics and Impacts of Itch in Children with Inflammatory Skin Disorders.
Abstract BACKGROUND: Itch is a cardinal feature of pediatric disorders and can impair quality of life. However, few studies have addressed symptoms and impacts of itch in pediatric patients. OBJECTIVES: We focused on understanding the child's experience of itch and impact of itch specifically on affected children, including by comparison with the adult experience. METHODS: Semi-structured interviews (9 parents/15 children with itch) explored concerns related to pediatric itch experiences and effects. Themes were compared with those of previous adult interviews. Literature was reviewed to identify need fo...
Source: The British Journal of Dermatology - September 6, 2020 Category: Dermatology Authors: Fang MM, Nowinski CJ, Lai J, Shaunfield S, Silverberg JI, Rangel SM, Cella D, Paller AS Tags: Br J Dermatol Source Type: research

The Epidemiology of Malignant Melanoma, Squamous Cell Carcinoma, and Basal Cell Carcinoma in the United Kingdom from 2004-2014: A Population-Based Cohort Analysis using the Clinical Practice Research Datalink.
Abstract Skin cancers, including malignant melanoma and keratinocyte skin cancers, are the most common malignancy in the United Kingdom (UK), and global incidence is increasing rapidly1 . While malignant melanoma (MM) accounts for most skin cancer deaths, keratinocyte skin cancers, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), comprise up to 95% of skin cancer cases in the UK2,3 . Studies on trends in MM incidence and survival have been conducted using Scottish, Northern Irish, and English and Welsh data4 . PMID: 32893341 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 6, 2020 Category: Dermatology Authors: Mirza FN, Yumeen S, Walter FM Tags: Br J Dermatol Source Type: research

Association of COVID-19 with skin diseases and relevant biologics: a cross-sectional study using nationwide claim data in South Korea.
CONCLUSIONS: Underlying skin diseases did not appear to increase susceptibility to COVID-19 or mortality from COVID-19. Considering the risks and benefits, biologics for dermatologic conditions might be continuously used during the COVID-19 pandemic. PMID: 32875557 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 2, 2020 Category: Dermatology Authors: Cho SI, Kim YE, Jo SJ Tags: Br J Dermatol Source Type: research

Villainous Hair: Ba(l)d to the Bone - Would they be so evil if they had hair?
Abstract In real-life, the impact of healthy hair on social perception has been extensively studied. But when it comes to the movies, do the hairstyles of villains also portray the physical embodiment of their immoral impulses? The more movies you watch, the easier it is to identify an emerging trend: bald characters are overwhelmingly villains. Alopecia seems to be innately associated with moral decay, as if the characters lack of hair and consequently their humanity was their evilness. At the same time, losing hair appears to be an adequate trigger for driving a character into a pit of immorality and crime. ...
Source: The British Journal of Dermatology - September 2, 2020 Category: Dermatology Authors: Kyriakou G, Drivelou V, Glentis A Tags: Br J Dermatol Source Type: research

Shades of grey: an outbreak of tattoo-associated Mycobacterium chelonae.
PMID: 32875558 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2020 Category: Dermatology Authors: Pararajasingam A, Atwan A, Srivastava P, Chowdhury MMU, Stone NM Tags: Br J Dermatol Source Type: research

The importance of provided information in contact allergy: key predictors on the road to success in the control of allergic contact dermatitis.
PMID: 32869277 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2020 Category: Dermatology Authors: Korkmaz P, Boyvat A Tags: Br J Dermatol Source Type: research

Spoiled for choice? Are you confused by the number of biological options for psoriasis?
PMID: 32869284 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2020 Category: Dermatology Authors: Ormerod AD Tags: Br J Dermatol Source Type: research

Abstracts for the British Association of Dermatologists 100th Annual Meeting, Virtual Meeting.
Authors: PMID: 32869291 [PubMed] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

Illuminating, through immunohistochemistry, the link between SARS-CoV-2 and pernio (chilblains).
PMID: 32869311 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2020 Category: Dermatology Authors: Wetter DA Tags: Br J Dermatol Source Type: research

Strong validation of ultrasound as an imaging biomarker in hidradenitis suppurativa.
PMID: 32869312 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2020 Category: Dermatology Authors: Wortsman X Tags: Br J Dermatol Source Type: research

Are existing quality-of-life instruments in cutaneous T-cell lymphoma of sufficient quality?
PMID: 32869313 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2020 Category: Dermatology Authors: Gabes M Tags: Br J Dermatol Source Type: research

Immune tolerance of allogeneic hematopoietic cell transplantation supports donor epidermal grafting of recessive dystrophic epidermolysis bullosa chronic wounds.
Abstract BACKGROUND: Chronic wounds, a common morbidity in recessive dystrophic epidermolysis bullosa (RDEB), lack definitive therapies. OBJECTIVE: To assess allogeneic epidermal skin grafts wound healing and durability over time. METHODS: In a prospective, open-label clinical trial for post-allogeneic hematopoietic cell transplantation (post-alloHCT) RDEB patients, up to 9 chronic wounds per patient were grafted over 1 year. Epidermal grafts measuring 5 cm2 were obtained from related alloHCT donors in the outpatient setting using the CELLUTOMETM Epidermal Harvesting System. Wounds were photographed and ...
Source: The British Journal of Dermatology - August 31, 2020 Category: Dermatology Authors: Ebens CL, McGrath JA, Riedl JA, Keith AR, Lilja G, Rusch S, Keene DR, Tufa SF, Riddle MJ, Shanley R, Van Heest AE, Tolar J Tags: Br J Dermatol Source Type: research

Algorithm based smartphone apps to assess risk of skin cancer in adults: critical appraisal of a systematic review.
Abstract Up to three million skin cancers occur worldwide annually, with an increasing burden over time1 . Melanomas, accounting for 4% of skin cancers, are responsible for 75% of deaths1,2 . An estimated 86% of melanomas in the UK are preventable3 . Self-monitoring, earlier detection and improvement in survival from melanoma are therefore of interest. Algorithm based smartphone applications (apps) are based on artificial intelligence algorithms trained on images of diagnosed skin cancer. They have the potential to facilitate early detection of otherwise aggressive life-threatening skin cancers, thus prompting use...
Source: The British Journal of Dermatology - August 31, 2020 Category: Dermatology Authors: Malhi IS, Yiu ZZN Tags: Br J Dermatol Source Type: research

Paucity of COVID-19 Dermatology Literature from Low- and Middle-Income Countries.
Abstract Since emerging in December 2019, COVID-19 has become a global pandemic with community transmission now reported in most World Health Organization (WHO) regions. As the pandemic progresses, there have been a growing number of reports of cutaneous manifestations and discussions of how COVID-19 has impacted clinical practice. We hypothesised that many such dermatology publications may be authored from high-income countries, raising questions about case representation and the generalisability and comprehensiveness of COVID-19 related insights, discourse, and guidance in our field. PMID: 32866992 [PubMed ...
Source: The British Journal of Dermatology - August 31, 2020 Category: Dermatology Authors: Pendse RS, Schwartz BL, Jia JL, Bailey EE Tags: Br J Dermatol Source Type: research

Skin disease case mix in the early 1920s: diagnoses prevalent at the time of the founding of the British Association of Dermatologists.
Abstract Dermatology is a ceaselessly changing specialty, no more so than currently, so it is unsurprising that the case mix of skin diseases presenting to a dermatologist a century ago, when our association was founded, should be different from today. For one thing, the overall healthcare context has changed. Life expectancy in 1920 at birth for a man was 55.6 years, and for a woman 59.6 years.1 Causes of death had transitioned from the nineteenth century pattern of being overwhelmingly due to infectious disease, to a predominance of respiratory and cardiovascular disease, with contribution from cancer.2 Access t...
Source: The British Journal of Dermatology - August 31, 2020 Category: Dermatology Authors: Gawkrodger DJ, Hunter JAA Tags: Br J Dermatol Source Type: research

How to break resistance to HHI (hedgehog inhibitors) in advanced BCC?
r R Abstract Egle Ramelyte has intermittent, project focused consulting or research relationships with Amgen, Novartis, Sanofi, Pierre Fabre and Galderma outside the submitted work. Mirjam Nägeli has intermittent, project focused consulting and/or advisory relationships with Sanofi, SunPharma outside the submitted work. Laurence Imhof has intermittent, project focused consulting and/or advisory relationships with Galderma outside the submitted work. PMID: 32867002 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 31, 2020 Category: Dermatology Authors: Nägeli MC, Ramelyte E, Restivo G, Imhof L, Dummer R Tags: Br J Dermatol Source Type: research

Publishing addiction: a behavioural disorder with specific characteristics.
Abstract By reading an academic journal, you are already at high-risk of publishing addiction (PA). So read on and see if you have it. PA is proposed as a previously unreported behavioural addiction. Gambling, excessive smartphone use and unrestrained shopping are other behavioural "addictions".1,2 Although widespread, PA is masked by its normalisation within academia, as alcoholism may be accepted in a brewery. PA can greatly impact the lives of those in its grip. PMID: 32860221 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 28, 2020 Category: Dermatology Authors: Finlay AY Tags: Br J Dermatol Source Type: research

Reproductive factors, hormone use and melanoma risk: an Australian prospective cohort study.
Abstract Despite many epidemiologic studies in the past two decades investigating whether hormonal and reproductive factors increase risk of melanoma, the issue remains unresolved.1 Findings appear to differ according to study design,2 with positive findings generally limited to case-control studies, which are prone to selection and recall bias. Given the relative paucity of prospective data on the topic, we aimed to assess the relationship between hormonal and reproductive factors and subsequent risk of melanoma in a large population-based cohort of Australian women. PMID: 32856295 [PubMed - as supplied by p...
Source: The British Journal of Dermatology - August 27, 2020 Category: Dermatology Authors: Olsen CM, Pandeya N, Dusingize JC, Thompson BS, Green AC, Neale RE, Webb PM, Whiteman DC, QSkin Study Tags: Br J Dermatol Source Type: research

Validation of a Clinicopathological and Gene Expression Profile (CP-GEP) model for sentinel lymph node metastasis in primary cutaneous melanoma.
CONCLUSIONS: The CP-GEP model is a non-invasive and validated tool that accurately identified patients with primary cutaneous melanoma at low risk for nodal metastasis. In this validation cohort, the CP-GEP model has shown potential to reduce SLNB procedures in melanoma patients. PMID: 32844403 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 26, 2020 Category: Dermatology Authors: Mulder EEAP, Dwarkasing JT, Tempel D, van A, der Spek, Bosman L, Verver D, Mooyaart AL, van AAM, der Veldt, Verhoef C, Nijsten TEC, Grunhagen DJ, Hollestein LM Tags: Br J Dermatol Source Type: research

Topical imiquimod monotherapy for a recurrent lesion of Merkel cell carcinoma.
PMID: 32845515 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 26, 2020 Category: Dermatology Authors: Miura H, Takada M, Fujiwara M, Fujiwara S Tags: Br J Dermatol Source Type: research

Characteristics modifying response to biologic treatments for psoriasis: considering subgroups in network meta-analysis.
Abstract Network meta-analysis (NMA) is a method used to estimate the relative effectiveness of different interventions in the absence of direct head-to-head trials. PMID: 32812647 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 19, 2020 Category: Dermatology Authors: Wade R, Sharif-Hurst S, Smith C, Dias S Tags: Br J Dermatol Source Type: research

Obituary: Professor Ronald Marks, 1935-2020.
PMID: 32808676 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 18, 2020 Category: Dermatology Authors: Finlay AY Tags: Br J Dermatol Source Type: research

Locoregional nodal extension does not impair prognosis of primary cutaneous anaplastic lymphomas.
Abstract primary cutaneous anaplastic lymphomas (pcALCL) commonly present as solitary or grouped skin lesions and have a 5-year specific survival greater than 91% (1-3). One study showed that, in cases of extracutaneous extension, 5-year overall survival is 41% (4). At diagnosis some patients have skin and locoregional node involvement but their prognosis is as favorable as that of patients with lesions limited to the skin (1). PMID: 32810288 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 18, 2020 Category: Dermatology Authors: D'Incan M, Ingen-Housz-Oro S, Beylot-Barry M, Joly P, Grange F, Quereux G, Templier I, Ram-Wolff C, Adamski H, Lambert C, Descours C Tags: Br J Dermatol Source Type: research

Prevalence, pathophysiology and management of itch in epidermolysis bullosa.
Abstract Epidermolysis bullosa (EB) is a highly diverse group of inherited skin disorders, resulting from mutations in genes encoding proteins of the dermal-epidermal junction (DEJ). Itch (pruritus) is one of the commonest symptoms across all EB subtypes. It occurs in blistered or wounded sites, or manifests as a generalized phenomenon, thereby affecting both intact skin and healing wounds. The mechanism of pruritus in EB is unclear. It is likely that skin inflammation secondary to barrier disruption, wound healing cascades and dysregulated activation of epidermal sensory nerve endings are all involved in its path...
Source: The British Journal of Dermatology - August 18, 2020 Category: Dermatology Authors: Papanikolaou M, Onoufriadis A, Mellerio JE, Nattkemper L, Yosipovitch G, Steinhoff M, McGrath JA Tags: Br J Dermatol Source Type: research

Chilblains and COVID-19: why SARS-CoV-2 endothelial infection is questioned.
Abstract Recently, Colmenero et al (1) demonstrated, by immunohistochemistry, the presence of SARS-CoV-2 in endothelial cells of skin biopsy specimens of chilblains in seven patients. These results raise some questions: The presence of the virus at cutaneous and vascular levels in otherwise asymptomatic patients with negative RT-PCR is unexpected. Vascular damage by direct viral effect is expected to be a sign of severity. It is also surprising that only feet are affected. PMID: 32798309 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 15, 2020 Category: Dermatology Authors: Baeck M, Hoton D, Marot L, Herman A Tags: Br J Dermatol Source Type: research

Chilblains and COVID-19: why SARS-CoV-2 endothelial infection is questioned: reply from authors.
, Torrelo A Abstract We thank Dr Baeck et al. for their interest in our recent article published by BJD1 . The negative RT-PCR in nasopharyngeal swabs in patients with COVID-19 chilblains has been extensively acknowledged in the literature, however a significant proportion of patients had mild systemic symptoms or contact with confirmed or suspected cases 2 . PMID: 32798316 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 15, 2020 Category: Dermatology Authors: Colmenero I, Santonja C, Alonso-Riaño M, Andina D, Rodríguez-Peralto JL, Requena L, Torrelo A Tags: Br J Dermatol Source Type: research

Intralesional rituximab in the treatment of indolent primary cutaneous B-cell lymphoma.
Abstract Primary cutaneous B-cell lymphomas (PCBCLs) are a heterogeneous group of extranodal lymphomas1 . Primary cutaneous marginal zone lymphoma (MZL) and follicle center lymphoma (FCL), the most prevalent PCBCLs, are typically indolent. PMID: 32798319 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 15, 2020 Category: Dermatology Authors: Chirico A, Henderson Berg MH, Roberge D, Pehr K Tags: Br J Dermatol Source Type: research