New international reporting guidelines for clinical trials evaluating effectiveness of artificial intelligence interventions in dermatology: strengthening the SPIRIT of robust trial reporting
Br J Dermatol. 2021 Mar;184(3):381-383. doi: 10.1111/bjd.19616.NO ABSTRACTPMID:33666954 | DOI:10.1111/bjd.19616 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 5, 2021 Category: Dermatology Authors: M Charalambides C Flohr P Bahadoran R N Matin Source Type: research

Melanoma-associated glycosyltransferase GCNT2 as an emerging biomarker and therapeutic target
Br J Dermatol. 2021 Mar 3. doi: 10.1111/bjd.19891. Online ahead of print.ABSTRACTIn metastatic melanoma, with a dismal survival rate and propensity for treatment resistance and recurrence, it is critical to establish biomarkers that better predict treatment response and disease severity. The melanoma glycome, composed of complex carbohydrates termed glycans, is an under investigated area of research though is gaining momentum in the cancer biomarker and therapeutics field. Novel findings suggest that glycans play a major role in influencing melanoma progression and could be exploited for prognosticating metastatic activity...
Source: The British Journal of Dermatology - March 4, 2021 Category: Dermatology Authors: M Perez A Chakraborty L S Lau N B B Mohammed C J Dimitroff Source Type: research

Regulatory noncoding RNAs help protect keratinocytes from ultraviolet-mediated damage in vitiligo
Br J Dermatol. 2021 Mar 3. doi: 10.1111/bjd.19827. Online ahead of print.NO ABSTRACTPMID:33660271 | DOI:10.1111/bjd.19827 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 4, 2021 Category: Dermatology Authors: C Cotter M Kretz N Rajan Source Type: research

The skin as a target for SARS-CoV-2 infection: exploiting the web for suitable data
Br J Dermatol. 2021 Mar 4. doi: 10.1111/bjd.19877. Online ahead of print.NO ABSTRACTPMID:33661523 | DOI:10.1111/bjd.19877 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 4, 2021 Category: Dermatology Authors: L Naldi Source Type: research

Silicone adhesive multilayered foam dressings for pressure ulcer prevention
Br J Dermatol. 2021 Mar 4. doi: 10.1111/bjd.19873. Online ahead of print.NO ABSTRACTPMID:33661525 | DOI:10.1111/bjd.19873 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 4, 2021 Category: Dermatology Authors: F Coyer Source Type: research

Melanoma-associated glycosyltransferase GCNT2 as an emerging biomarker and therapeutic target
Br J Dermatol. 2021 Mar 3. doi: 10.1111/bjd.19891. Online ahead of print.ABSTRACTIn metastatic melanoma, with a dismal survival rate and propensity for treatment resistance and recurrence, it is critical to establish biomarkers that better predict treatment response and disease severity. The melanoma glycome, composed of complex carbohydrates termed glycans, is an under investigated area of research though is gaining momentum in the cancer biomarker and therapeutics field. Novel findings suggest that glycans play a major role in influencing melanoma progression and could be exploited for prognosticating metastatic activity...
Source: The British Journal of Dermatology - March 4, 2021 Category: Dermatology Authors: M Perez A Chakraborty L S Lau N B B Mohammed C J Dimitroff Source Type: research

Regulatory noncoding RNAs help protect keratinocytes from ultraviolet-mediated damage in vitiligo
Br J Dermatol. 2021 Mar 3. doi: 10.1111/bjd.19827. Online ahead of print.NO ABSTRACTPMID:33660271 | DOI:10.1111/bjd.19827 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 4, 2021 Category: Dermatology Authors: C Cotter M Kretz N Rajan Source Type: research

Four childhood atopic dermatitis subtypes identified from trajectory and severity of disease and internally validated in a large UK birth cohort
CONCLUSIONS: Considering severity and AD trajectories leads to four well-defined and recognisable subtypes. The differential associations of risk factors among and between subtypes is novel and requires further research.PMID:33655501 | DOI:10.1111/bjd.19885 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 3, 2021 Category: Dermatology Authors: A R Mulick K E Mansfield R J Silverwood A Buddu-Aggrey A Roberts A Custovic N Pearce A D Irvine L Smeeth K Abuabara S M Langan Source Type: research

Epidemiology of cutaneous lymphoma
Br J Dermatol. 2021 Mar 3. doi: 10.1111/bjd.19829. Online ahead of print.NO ABSTRACTPMID:33656170 | DOI:10.1111/bjd.19829 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 3, 2021 Category: Dermatology Authors: M Vermeer Source Type: research

The less known face of Dupilumab: its role in mesenchymal stem cells by IL13 modulation
Br J Dermatol. 2021 Mar 3. doi: 10.1111/bjd.19892. Online ahead of print.ABSTRACTAtopic dermatitis (AD) is an inflammatory disease that may persist into adulthood, becoming a lifelong condition1 . Dupilumab, a human monoclonal antibody, inhibits both IL4 and IL13, two master players of AD, by blocking the shared IL4Rα subunit, thus emerging as an interesting option for the treatment of adult AD.PMID:33657639 | DOI:10.1111/bjd.19892 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 3, 2021 Category: Dermatology Authors: A Campanati M Di Vincenzo G Radi G Rizzetto G Carnevale S Marchi M Orciani A Offidani Source Type: research

Mortality and clinical response of patients with bullous pemphigoid treated with rituximab
Br J Dermatol. 2021 Mar 3. doi: 10.1111/bjd.19890. Online ahead of print.ABSTRACTBullous pemphigoid (BP) is one of the most common autoimmune bullous diseases characterized by autoantibodies targeting BP230 and BP180. BP usually occurs in individuals over 70 years of age and shows a high mortality rate.1,2 In the meta-analysis, the 1-year mortality rate of BP patients was reported to be 23.5%.2 Rituximab, a monoclonal antibody targeting CD20, has shown high therapeutic efficacy in BP patients although the use of rituximab in BP is not approved in most countries including Europe and U.S.PMID:33657641 | DOI:10.1111/bjd.19890...
Source: The British Journal of Dermatology - March 3, 2021 Category: Dermatology Authors: D S Yoo J H Lee S-C Kim J H Kim Source Type: research

Identifying Gaps in Global Health Dermatology: A Survey of GLODERM Members
Br J Dermatol. 2021 Mar 3. doi: 10.1111/bjd.19889. Online ahead of print.ABSTRACTGlobal health is a multidisciplinary field with a focus on improving health for all people worldwide. Interest in global health continues to grow, with 24% of U.S. medical students completing global health experiences during medical school.PMID:33657642 | DOI:10.1111/bjd.19889 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 3, 2021 Category: Dermatology Authors: D E McMahon L Oyesiku E Amerson H Beltraminelli A Y Chang A Forrestel R Hay A Knapp C Kovarik T Maurer S A Norton W Rehmus C Van Hees K A Wanat V L Williams L C Fuller E E Freeman Source Type: research

Cold and COVID: Recurrent Pernio during the COVID-19 Pandemic
Br J Dermatol. 2021 Mar 3. doi: 10.1111/bjd.19894. Online ahead of print.ABSTRACTPernio is a commonly reported cutaneous manifestation of SARS-CoV-2 infection.1 Our international registry of COVID-19 dermatologic manifestations has collected 1,176 total cases of COVID-19 skin manifestations, including 619 cases of pernio in suspected or confirmed COVID-19 patients.1 Most patients with new-onset pernio were entered into the registry after the first pandemic wave (79% in March-May 2020). Starting in September 2020, the registry received reports of a subset of these patients who developed recurrent pernio in the following mon...
Source: The British Journal of Dermatology - March 3, 2021 Category: Dermatology Authors: E E Freeman D E McMahon J B Lipoff M Rosenbach S R Desai M Fassett L E French H W Lim G J Hruza L P Fox Source Type: research

Predicting sentinel node positivity in melanoma patients: external validation of a risk-prediction calculator (the MIA nomogram) using a large European population-based patient cohort
CONCLUSIONS: This population-based validation study in European melanoma patients confirmed the value of the MIA nomogram in predicting SN-positivity. Its use will spare low-risk patients the inconvenience, cost and potential risks of SN biopsy while ensuring that high-risk patients are still identified.PMID:33657653 | DOI:10.1111/bjd.19895 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 3, 2021 Category: Dermatology Authors: M A El Sharouni A H R Varey A J Witkamp T Ahmed V Sigurdsson P J van Diest R A Scolyer J F Thompson S N Lo C H van Gils Source Type: research

Oral dimethyl fumarate induces changes within the peripheral neutrophil compartment of psoriasis patients that are linked with skin improvement
CONCLUSIONS: Our results reveal a novel in vivo effect of DMF therapy on pro-inflammatory neutrophils that likely contributes to this treatment's anti-psoriatic efficacy.PMID:33657656 | DOI:10.1111/bjd.19899 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 3, 2021 Category: Dermatology Authors: P J Morrison I Suhrkamp S Gerdes U Mrowietz Source Type: research

Current prevalence and relevance of positive patch test reactions to cosmetic and non-cosmetic isothiazolinones in the UK
Br J Dermatol. 2021 Mar 3. doi: 10.1111/bjd.19898. Online ahead of print.ABSTRACTIsothiazolinones, such as methylisothiazolinone (MI), the mixture of methylchloroisothiazolinone and MI (MCI/MI), benzisothiazolinone (BIT) and octylisothiazolinone (OIT), are preservatives widely used in personal care products, cleaning materials, leather, glue, industrial chemicals, and paints.PMID:33657657 | DOI:10.1111/bjd.19898 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 3, 2021 Category: Dermatology Authors: L F Soriano M M U Chowdhury S M Cooper P Cousen S Dawe A Havelin C R Holden G A Johnston D I Orton A Ramoutar N M Stone D A Thompson D A Buckley Source Type: research

Dupilumab treatment in atopic dermatitis patients in the Netherlands versus Japan: a comparative cohort study revealing a discrepancy in patient-reported outcome measures
Br J Dermatol. 2021 Mar 3. doi: 10.1111/bjd.19897. Online ahead of print.ABSTRACTBACKGROUND: Dupilumab was equally effective among all racial subgroups in clinical trials, but a direct comparison in daily practice is lacking.OBJECTIVE: To investigate effectiveness of dupilumab in atopic dermatitis (AD) patients in the Netherlands versus Japan up to 80 weeks of treatment.METHODS: A longitudinal comparative cohort study was conducted in AD patients who were treated with dupilumab in daily practice. We used linear mixed-effects models to determine changes in time.RESULTS: We found statistically significant differences in sex,...
Source: The British Journal of Dermatology - March 3, 2021 Category: Dermatology Authors: L E M de Wijs R F T Fujimoto E R Andrinopoulou T E C Nijsten D Hijnen Y Kataoka Source Type: research

Supportive care in the acute phase of Stevens-Johnson syndrome and toxic epidermal necrolysis: an international, multidisciplinary DELPHI-based consensus
CONCLUSIONS: We have reached an international Delphi-based consensus on best supportive care practice for SJS/TEN. Our expert consensus should help guide physicians in treating patients with SJS/TEN and thereby improve short-term prognosis and the risk of sequelae.PMID:33657677 | DOI:10.1111/bjd.19893 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 3, 2021 Category: Dermatology Authors: M-C Br üggen S T Le S Walsh A Toussi N de Prost A Ranki B Didona A Colin B Horv áth E Brezinova B Milpied C Moss C Bodemer D Meyersburg C Salavastru G-S Tiplica E Howard E Bequignon J N Bouwes Bavinck J Newman J Gueudry M N ägeli K Zaghbib K Pallesen A Source Type: research

Coexistence of palmoplantar pustulosis and ichthyosis vulgaris treated by risankizumab
Br J Dermatol. 2021 Mar 1. doi: 10.1111/bjd.19835. Online ahead of print.NO ABSTRACTPMID:33646608 | DOI:10.1111/bjd.19835 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 1, 2021 Category: Dermatology Authors: J Hugo M Arenbergerova P Arenberger S Gkalpakiotis Source Type: research

Coexistence of palmoplantar pustulosis and ichthyosis vulgaris treated by risankizumab
Br J Dermatol. 2021 Mar 1. doi: 10.1111/bjd.19835. Online ahead of print.NO ABSTRACTPMID:33646608 | DOI:10.1111/bjd.19835 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 1, 2021 Category: Dermatology Authors: J Hugo M Arenbergerova P Arenberger S Gkalpakiotis Source Type: research

Skin-associated lymphoid tissue could be a sign of systemic disease
Br J Dermatol. 2021 Feb 21. doi: 10.1111/bjd.19881. Online ahead of print.ABSTRACTKamido et al. reported a 63-year-old female with Schnitzler syndrome but recurrent erythematous patches even with Anakinra treatment [1]. Skin biopsy obtained before Anakinra initiation showed an underlying lymphoid follicle with a germinal center surrounded by plasma cells. Moreover, vascularity with high endothelial venule formation was also seen.PMID:33615440 | DOI:10.1111/bjd.19881 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 22, 2021 Category: Dermatology Authors: C Wang Source Type: research

Skin-associated lymphoid tissue could be a sign of systemic disease: reply from authors
Br J Dermatol. 2021 Feb 22. doi: 10.1111/bjd.19884. Online ahead of print.ABSTRACTWe thank Dr. Wang for pointing out that Castleman disease and cutaneous plasmacytosis are potential differential diagnoses1 in our case2 . In general, Castleman disease and cutaneous plasmacytosis typically manifest as a "Christmas tree-like" distribution of dark brownish nodules on the trunk. In addition, the histopathology exhibits dense plasma cell accumulation in the dermis in Castleman disease and cutaneous plasmacytosis, which was not observed in our case.PMID:33615442 | DOI:10.1111/bjd.19884 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 22, 2021 Category: Dermatology Authors: T Kogame N Kambe R Takimoto-Ito T Nomura K Kabashima Source Type: research

Skin-associated lymphoid tissue could be a sign of systemic disease
Br J Dermatol. 2021 Feb 21. doi: 10.1111/bjd.19881. Online ahead of print.ABSTRACTKamido et al. reported a 63-year-old female with Schnitzler syndrome but recurrent erythematous patches even with Anakinra treatment [1]. Skin biopsy obtained before Anakinra initiation showed an underlying lymphoid follicle with a germinal center surrounded by plasma cells. Moreover, vascularity with high endothelial venule formation was also seen.PMID:33615440 | DOI:10.1111/bjd.19881 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 22, 2021 Category: Dermatology Authors: C Wang Source Type: research

Skin-associated lymphoid tissue could be a sign of systemic disease: reply from authors
Br J Dermatol. 2021 Feb 22. doi: 10.1111/bjd.19884. Online ahead of print.ABSTRACTWe thank Dr. Wang for pointing out that Castleman disease and cutaneous plasmacytosis are potential differential diagnoses1 in our case2 . In general, Castleman disease and cutaneous plasmacytosis typically manifest as a "Christmas tree-like" distribution of dark brownish nodules on the trunk. In addition, the histopathology exhibits dense plasma cell accumulation in the dermis in Castleman disease and cutaneous plasmacytosis, which was not observed in our case.PMID:33615442 | DOI:10.1111/bjd.19884 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 22, 2021 Category: Dermatology Authors: T Kogame N Kambe R Takimoto-Ito T Nomura K Kabashima Source Type: research

Skin-associated lymphoid tissue could be a sign of systemic disease
Br J Dermatol. 2021 Feb 21. doi: 10.1111/bjd.19881. Online ahead of print.ABSTRACTKamido et al. reported a 63-year-old female with Schnitzler syndrome but recurrent erythematous patches even with Anakinra treatment [1]. Skin biopsy obtained before Anakinra initiation showed an underlying lymphoid follicle with a germinal center surrounded by plasma cells. Moreover, vascularity with high endothelial venule formation was also seen.PMID:33615440 | DOI:10.1111/bjd.19881 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 22, 2021 Category: Dermatology Authors: C Wang Source Type: research

Skin-associated lymphoid tissue could be a sign of systemic disease: reply from authors
Br J Dermatol. 2021 Feb 22. doi: 10.1111/bjd.19884. Online ahead of print.ABSTRACTWe thank Dr. Wang for pointing out that Castleman disease and cutaneous plasmacytosis are potential differential diagnoses1 in our case2 . In general, Castleman disease and cutaneous plasmacytosis typically manifest as a "Christmas tree-like" distribution of dark brownish nodules on the trunk. In addition, the histopathology exhibits dense plasma cell accumulation in the dermis in Castleman disease and cutaneous plasmacytosis, which was not observed in our case.PMID:33615442 | DOI:10.1111/bjd.19884 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 22, 2021 Category: Dermatology Authors: T Kogame N Kambe R Takimoto-Ito T Nomura K Kabashima Source Type: research

Skin-associated lymphoid tissue could be a sign of systemic disease
Br J Dermatol. 2021 Feb 21. doi: 10.1111/bjd.19881. Online ahead of print.ABSTRACTKamido et al. reported a 63-year-old female with Schnitzler syndrome but recurrent erythematous patches even with Anakinra treatment [1]. Skin biopsy obtained before Anakinra initiation showed an underlying lymphoid follicle with a germinal center surrounded by plasma cells. Moreover, vascularity with high endothelial venule formation was also seen.PMID:33615440 | DOI:10.1111/bjd.19881 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 22, 2021 Category: Dermatology Authors: C Wang Source Type: research

Skin-associated lymphoid tissue could be a sign of systemic disease: reply from authors
Br J Dermatol. 2021 Feb 22. doi: 10.1111/bjd.19884. Online ahead of print.ABSTRACTWe thank Dr. Wang for pointing out that Castleman disease and cutaneous plasmacytosis are potential differential diagnoses1 in our case2 . In general, Castleman disease and cutaneous plasmacytosis typically manifest as a "Christmas tree-like" distribution of dark brownish nodules on the trunk. In addition, the histopathology exhibits dense plasma cell accumulation in the dermis in Castleman disease and cutaneous plasmacytosis, which was not observed in our case.PMID:33615442 | DOI:10.1111/bjd.19884 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 22, 2021 Category: Dermatology Authors: T Kogame N Kambe R Takimoto-Ito T Nomura K Kabashima Source Type: research

Skin-associated lymphoid tissue could be a sign of systemic disease
Br J Dermatol. 2021 Feb 21. doi: 10.1111/bjd.19881. Online ahead of print.ABSTRACTKamido et al. reported a 63-year-old female with Schnitzler syndrome but recurrent erythematous patches even with Anakinra treatment [1]. Skin biopsy obtained before Anakinra initiation showed an underlying lymphoid follicle with a germinal center surrounded by plasma cells. Moreover, vascularity with high endothelial venule formation was also seen.PMID:33615440 | DOI:10.1111/bjd.19881 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 22, 2021 Category: Dermatology Authors: C Wang Source Type: research

Skin-associated lymphoid tissue could be a sign of systemic disease: reply from authors
Br J Dermatol. 2021 Feb 22. doi: 10.1111/bjd.19884. Online ahead of print.ABSTRACTWe thank Dr. Wang for pointing out that Castleman disease and cutaneous plasmacytosis are potential differential diagnoses1 in our case2 . In general, Castleman disease and cutaneous plasmacytosis typically manifest as a "Christmas tree-like" distribution of dark brownish nodules on the trunk. In addition, the histopathology exhibits dense plasma cell accumulation in the dermis in Castleman disease and cutaneous plasmacytosis, which was not observed in our case.PMID:33615442 | DOI:10.1111/bjd.19884 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 22, 2021 Category: Dermatology Authors: T Kogame N Kambe R Takimoto-Ito T Nomura K Kabashima Source Type: research

Skin-associated lymphoid tissue could be a sign of systemic disease
Br J Dermatol. 2021 Feb 21. doi: 10.1111/bjd.19881. Online ahead of print.ABSTRACTKamido et al. reported a 63-year-old female with Schnitzler syndrome but recurrent erythematous patches even with Anakinra treatment [1]. Skin biopsy obtained before Anakinra initiation showed an underlying lymphoid follicle with a germinal center surrounded by plasma cells. Moreover, vascularity with high endothelial venule formation was also seen.PMID:33615440 | DOI:10.1111/bjd.19881 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 22, 2021 Category: Dermatology Authors: C Wang Source Type: research

Skin-associated lymphoid tissue could be a sign of systemic disease: reply from authors
Br J Dermatol. 2021 Feb 22. doi: 10.1111/bjd.19884. Online ahead of print.ABSTRACTWe thank Dr. Wang for pointing out that Castleman disease and cutaneous plasmacytosis are potential differential diagnoses1 in our case2 . In general, Castleman disease and cutaneous plasmacytosis typically manifest as a "Christmas tree-like" distribution of dark brownish nodules on the trunk. In addition, the histopathology exhibits dense plasma cell accumulation in the dermis in Castleman disease and cutaneous plasmacytosis, which was not observed in our case.PMID:33615442 | DOI:10.1111/bjd.19884 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 22, 2021 Category: Dermatology Authors: T Kogame N Kambe R Takimoto-Ito T Nomura K Kabashima Source Type: research

Intention of COVID-19 vaccination among psoriatic patients compared to immunosuppressed patients with other skin diseases and factors influencing their decision
Br J Dermatol. 2021 Feb 20. doi: 10.1111/bjd.19882. Online ahead of print.ABSTRACTPsoriasis (Ps) is a chronic, immune-mediated skin disease with systemic involvement. Therapeutic advancements in its management have considerably improved disease activity and quality of life, and reduced hospitalization rates. Nevertheless, prolonged immunosuppression in psoriatic patients may increase their susceptibility to opportunistic infections.PMID:33609286 | DOI:10.1111/bjd.19882 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 20, 2021 Category: Dermatology Authors: E Sotiriou K Bakirtzi I Papadimitriou E Paschou E Vakirlis A Lallas D Ioannides Source Type: research

Invasive and In-Situ Squamous Cell Carcinoma of the Skin: A Nationwide Study in Iceland
CONCLUSION: cSCC has become an increasingly significant public health problem in Iceland. Tanning bed use and traveling abroad might contribute to skin cancer development. Public health efforts are needed to stem the behaviors leading to this rapid rise in cSCC.PMID:33609287 | DOI:10.1111/bjd.19879 (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 20, 2021 Category: Dermatology Authors: J A Adalsteinsson E Olafsdottir D Ratner R Waldman H Feng J Ungar J I Silverberg A K Kristjansson J G Jonasson L Tryggvadottir Source Type: research

Risk of skin cancer in new users of thiazides and thiazide-like diuretics: a cohort study using an active comparator group
Br J Dermatol. 2021 Feb 20. doi: 10.1111/bjd.19880. Online ahead of print.ABSTRACTBACKGROUND: Case-control studies report a dose-dependent increased risk of skin cancer in users of hydrochlorothiazide (HCTZ) vs non-users. The degree to which other thiazides and thiazide-like diuretics (TZs) are associated with skin cancer is less certain.OBJECTIVES: To assess the risk of skin cancer in new users of different TZs compared to new users of calcium channel blockers (CCBs).METHODS: We conducted a cohort study using a UK primary-care database (1998-2017), including 271 154 new TZ users (87.6% bendroflumethiazide [BFT], 5.8% inda...
Source: The British Journal of Dermatology - February 20, 2021 Category: Dermatology Authors: R Schneider D Reinau S Stoffel S S Jick C R Meier J Spoendlin Source Type: research

Intention of COVID-19 vaccination among psoriatic patients compared to immunosuppressed patients with other skin diseases and factors influencing their decision.
Abstract Psoriasis (Ps) is a chronic, immune-mediated skin disease with systemic involvement. Therapeutic advancements in its management have considerably improved disease activity and quality of life, and reduced hospitalization rates. Nevertheless, prolonged immunosuppression in psoriatic patients may increase their susceptibility to opportunistic infections. PMID: 33609286 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 20, 2021 Category: Dermatology Authors: Sotiriou E, Bakirtzi K, Papadimitriou I, Paschou E, Vakirlis E, Lallas A, Ioannides D Tags: Br J Dermatol Source Type: research

Invasive and In-Situ Squamous Cell Carcinoma of the Skin: A Nationwide Study in Iceland.
CONCLUSION: cSCC has become an increasingly significant public health problem in Iceland. Tanning bed use and traveling abroad might contribute to skin cancer development. Public health efforts are needed to stem the behaviors leading to this rapid rise in cSCC. PMID: 33609287 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 20, 2021 Category: Dermatology Authors: Adalsteinsson JA, Olafsdottir E, Ratner D, Waldman R, Feng H, Ungar J, Silverberg JI, Kristjansson AK, Jonasson JG, Tryggvadottir L Tags: Br J Dermatol Source Type: research

Risk of skin cancer in new users of thiazides and thiazide-like diuretics: a cohort study using an active comparator group.
Abstract BACKGROUND: Case-control studies report a dose-dependent increased risk of skin cancer in users of hydrochlorothiazide (HCTZ) vs non-users. The degree to which other thiazides and thiazide-like diuretics (TZs) are associated with skin cancer is less certain. OBJECTIVES: To assess the risk of skin cancer in new users of different TZs compared to new users of calcium channel blockers (CCBs). METHODS: We conducted a cohort study using a UK primary-care database (1998-2017), including 271 154 new TZ users (87.6% bendroflumethiazide [BFT], 5.8% indapamide, and 3.6% HCTZ) and 275 263 CCB...
Source: The British Journal of Dermatology - February 20, 2021 Category: Dermatology Authors: Schneider R, Reinau D, Stoffel S, Jick SS, Meier CR, Spoendlin J Tags: Br J Dermatol Source Type: research

Classifying the severity of bullous pemphigoid disease.
PMID: 33599983 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 18, 2021 Category: Dermatology Authors: Blome C, Klein TM Tags: Br J Dermatol Source Type: research

The importance of keratinocyte-dendritic cell interactions in understanding fragrance allergy.
PMID: 33600000 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 18, 2021 Category: Dermatology Authors: Pilkington SM Tags: Br J Dermatol Source Type: research

Priority research questions in atopic dermatitis: An International Eczema Council eDelphi consensus.
Abstract Recent advances in understanding the complex pathogenesis of atopic dermatitis (AD, also known as eczema or atopic eczema), coupled with the development of new treatments, have led to increased interest from multiple stakeholders. There is a need to prioritize areas for research to inform a coordinated approach to advancing science and patient care. We sought to fill a gap in the literature, specifically from the perspective of clinicians involved in AD patient care and research. PMID: 33570761 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 11, 2021 Category: Dermatology Authors: Abuabara K, Nicholls SG, Langan SM, Guttman-Yassky E, Reynolds NJ, Paller AS, Brown SJ, International Eczema Council Priority Research Group Tags: Br J Dermatol Source Type: research

Ultraviolet-related skin cancers distribute differently on the face surface.
Abstract We retrospectively collected the data of Japanese patients with basal cell carcinoma (BCC; 292 lesions from 292 cases; 139 men and 153 women; mean age: 75 years), invasive squamous cell carcinoma (SCC; 118 lesions from 118 cases; 56 men and 62 women; mean age: 85 years), or melanoma (51 lesions from 51 cases; 23 men and 28 women; mean age: 78 years) on the face treated at Shinshu University Hospital between January 2000 and December 2017. PMID: 33566363 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 10, 2021 Category: Dermatology Authors: Omodaka T, Minagawa A, Okuyama R Tags: Br J Dermatol Source Type: research

Biologics utilization for psoriasis is lower in Black compared to Caucasian patients.
Abstract Psoriasis is a chronic inflammatory condition that affects patients of all skin colors. Biologic therapies, first approved for psoriasis in the early 2000s, have ushered in a new era of treatments for moderate to severe psoriasis and psoriatic arthritis. Non-Caucasian patients have a lower prevalence of psoriasis (1.9% in Blacks, 1.6% in Hispanics, and 1.4% in other races) compared to Caucasians (3.6%),1 but often present with worse disease severity.2 Yet, little is known about the utilization of biologic therapies versus traditional therapies in patients of color. To address this gap in knowledge, we sou...
Source: The British Journal of Dermatology - February 10, 2021 Category: Dermatology Authors: Hodges WT, Bhat T, Raval NS, Herbosa C, Ugwu-Dike P, Kwatra SG, Musiek A, Mann C, Semenov YR Tags: Br J Dermatol Source Type: research

The use of hydroxychloroquine as a systemic treatment in erosive lichen planus of the vulva and vagina.
;th B Abstract Erosive lichen planus affecting the vulva and vagina (ELPV) is a rare inflammatory skin disease, presenting with painful erosions and severe scarring.1 The disease course is persistent and often refractory to treatment: up to 45% patients do not experience remission with topical treatments, while evidence for systemic treatments remains scarce.2 Hydroxychloroquine (HCQ) is frequently used in daily practice as a first choice systemic therapy.3 However, little evidence is available on HCQ for ELPV.2 The aim of this study was to analyse the effectiveness and safety of HCQ in ELPV. PMID: 33548058 [...
Source: The British Journal of Dermatology - February 6, 2021 Category: Dermatology Authors: Vermeer HAB, Rashid H, Esajas MD, Oldhoff JM, Horváth B Tags: Br J Dermatol Source Type: research

Longitudinal multicenter retrospective cohort study of treatment outcomes in extramammary Paget's disease.
Abstract Extramammary Paget's disease (EMPD) is a rare, usually intraepithelial, cutaneous adenocarcinoma morphologically and histologically similar to mammary Paget's arising in areas outside of the lactiferous tissue. Management options include wide local excision (WLE) or Mohs surgery; radiotherapy, photodynamic therapy, laser ablation, topical therapies, and systemic chemotherapy.1 Regardless of therapy, disease recurrence is common and problematic.2,3 While large database studies have examined mortality rates for various populations of EMPD patients;4,5 longitudinal experience of patients with EMPD, including...
Source: The British Journal of Dermatology - February 6, 2021 Category: Dermatology Authors: Liu KX, Huang V, Chen CA, Elco CP, Chen ST, Stern RS, Wu PA Tags: Br J Dermatol Source Type: research

Pain  Severity following Cryotherapy for Actinic Keratoses and Patient Tolerability of Treatment.
Pain Severity following Cryotherapy for Actinic Keratoses and Patient Tolerability of Treatment. Br J Dermatol. 2021 Feb 05;: Authors: Quinn G, MacEochagain C, Mac Mahon J, Killion L, Ralph N, Lenane P, Murad A, McDonald I, Moloney FJ Abstract Jackson et al identify pain as the main side effect of microwave therapy for actinic keratoses (AK) and recommend a randomised controlled trial against cryotherapy to confirm clinical efficacy and patient acceptability.1  Cryotherapy, is a long established treatment for focal AK2  with retrospective studies demonstrat...
Source: The British Journal of Dermatology - February 5, 2021 Category: Dermatology Authors: Quinn G, MacEochagain C, Mac Mahon J, Killion L, Ralph N, Lenane P, Murad A, McDonald I, Moloney FJ Tags: Br J Dermatol Source Type: research

Oral clindamycin and rifampicin in the treatment of hidradenitis suppurativa-acne inverse in paediatric age: a pilot, prospective study.
Abstract Hidradenitis suppurativa-acne inversa (HS-AI) is a chronic, inflammatory, recurrent, debilitating skin disease of the terminal hair follicle that usually presents with painful, deep-seated, inflamed lesions in the apocrine-gland-bearing areas of the body.The disease typically occurs in the second and third decade of life but an early onset, in paediatric age (0-16 years), is reported in 2% to 8.1% of patients. PMID: 33544882 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 5, 2021 Category: Dermatology Authors: Bettoli V, Toni G, Odorici G, Forconi R, Corazza M Tags: Br J Dermatol Source Type: research

Five-year efficacy and safety of tildrakizumab in patients with moderate to severe psoriasis who respond at week 28: pooled analyses of two randomised phase 3 clinical trials (reSURFACE 1 and reSURFACE 2).
We present 5-year pooled data from reSURFACE 1 and reSURFACE 2. METHODS: reSURFACE 1 and reSURFACE 2 were double-blind, randomised, controlled studies with optional long-term extensions. Adults with moderate-to-severe chronic plaque psoriasis were randomised 2:2:1 to tildrakizumab 100 (TIL100) or 200 mg (TIL200) or placebo at weeks 0 and 4, and every 12 weeks thereafter (reSURFACE 2 included an etanercept arm). Efficacy outcomes included proportions of patients achieving absolute and relative improvement from baseline Psoriasis Area and Severity Index (PASI) score through week 244 in tildrakizumab responders (≥75% ...
Source: The British Journal of Dermatology - February 5, 2021 Category: Dermatology Authors: Thaçi D, Piaserico S, Warren RB, Gupta AK, Cantrell W, Draelos Z, Foley P, Igarashi A, Langley RG, Asahina A, Young M, Falqués M, Pau-Charles I, Mendelsohn AM, Rozzo SJ, Reich K Tags: Br J Dermatol Source Type: research

Exploring the melanoma survivorship experience: a qualitative study.
Abstract Cutaneous melanomas are the fifth most common cancer in the United States and the United Kingdom, with a 5-year relative survival of 87-93%.1,2 Targeted and immune checkpoint therapies have further expanded the number of advanced melanoma survivors. Cancer survivorship recommendations have been published by Macmillan Cancer Support; yet programs for melanoma survivors in the US are still in their infancy.3 We aimed to explore experiences and challenges that US patients diagnosed with melanoma experienced in a tertiary cancer centre using in-depth interviews. PMID: 33544884 [PubMed - as supplied by pu...
Source: The British Journal of Dermatology - February 5, 2021 Category: Dermatology Authors: Wolner ZJ, Flowers NI, Yushak ML, Chen SC, Yeung H Tags: Br J Dermatol Source Type: research

Trends in opioid prescribing at outpatient visits for psoriasis and psoriatic arthritis.
The objective of this study was to examine trends in opioid prescribing at outpatient visits for psoriasis and PsA in the United States (US). PMID: 33544885 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 5, 2021 Category: Dermatology Authors: Taylor MT, Noe MH, Horton DB, Barbieri JS Tags: Br J Dermatol Source Type: research