Limited effectiveness of four oral antifungal drugs (fluconazole, griseofulvin, itraconazole and terbinafine) in the current epidemic of altered dermatophytosis in India: results of a randomized pragmatic trial.
Abstract BACKGROUND: Dermatophytic infections have undergone unprecedented changes in India in the recent past. Clinical trials to find out the effectiveness of the four main oral antifungal drugs are lacking. OBJECTIVES: We tested the effectiveness of oral fluconazole, griseofulvin, itraconazole and terbinafine in chronic and chronic relapsing tinea corporis, tinea cruris and tinea faciei in an investigator-initiated, randomized, pragmatic trial. METHODS: Two hundred patients with microscopy-confirmed tinea were allocated to four groups (50 patients in each group): fluconazole 5 mg kg-1 per day, griseof...
Source: The British Journal of Dermatology - June 15, 2020 Category: Dermatology Authors: Singh S, Chandra U, Anchan VN, Verma P, Tilak R Tags: Br J Dermatol Source Type: research

How to measure itch in atopic dermatitis?
PMID: 32538467 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 15, 2020 Category: Dermatology Authors: Oosterhaven JAF Tags: Br J Dermatol Source Type: research

Sars-CoV-2 infection: the same virus can cause different cutaneous manifestations.
Abstract The article of Galván Casas et al. describing the cutaneous manifestations occurring during the COVID-19 pandemic1 prompted us to make some observations. Informations regarding the prevalence of enanthems, their clinical features and the association with exanthem patterns and disease severity are lacking. In the absence of a clearly defined temporal connection, the relationship between exanthems and SARS-CoV-2 infection is at times unclear, as in the case of urticarial/maculopapular eruptions in patients undergoing treatment with multiple drugs. PMID: 32533844 [PubMed - as supplied by publishe...
Source: The British Journal of Dermatology - June 13, 2020 Category: Dermatology Authors: Drago F, Ciccarese G, Rebora A, Muzic SI, Parodi A Tags: Br J Dermatol Source Type: research

Bacterial and fungal microbiome characterization in patients with rosacea and healthy controls.
Abstract Rosacea is a common inflammatory skin disease, but its pathophysiology is still unclear. Several microorganisms, including Cutibacterium acnes, Demodex spp. and Staphylococcus epidermidis, have been suggested to play roles in its pathogenesis. However, it is suspected that the community of microorganisms in and on the skin, rather than a single species, plays a more causative role in the disease. Our study aims to characterize and compare the skin bacterial and fungal microbiome in rosacea patients and healthy controls. PMID: 32533846 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 13, 2020 Category: Dermatology Authors: Wang R, Farhat M, Na J, Li R, Wu Y Tags: Br J Dermatol Source Type: research

Diagnostic and Therapeutic Differences Between Immune Checkpoint Inhibitor-Induced and Idiopathic Bullous Pemphigoid: A Cross-Sectional Study.
Abstract Bullous pemphigoid (BP) is a serious, rare complication from immune checkpoint inhibitors (ICIs). While most dermatologic immune-related adverse events (irAEs) present early and are mild, ICI-induced BP (ICI-BP) manifests months into therapy and can prompt ICI discontinuation and severe immunosuppression. Following irAE management guidelines, providers rely on systemic corticosteroids - which, at high doses, may confer poorer oncologic outcomes for ICI patients. Our study aims to identify diagnostic and therapeutic differences between ICI-BP and idiopathic BP (iBP) to assist providers in prompt recognitio...
Source: The British Journal of Dermatology - June 12, 2020 Category: Dermatology Authors: Molina GE, Reynolds KL, Chen ST Tags: Br J Dermatol Source Type: research

Long-Term Safety of Certolizumab Pegol in Plaque Psoriasis: Pooled Analysis over 3 Years from Three Phase 3, Randomised, Placebo-Controlled Studies.
CONCLUSIONS: No new safety signals were identified compared to previously reported data. Risk did not increase with longer or higher CZP exposure. PMID: 32531798 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 12, 2020 Category: Dermatology Authors: Blauvelt A, Paul C, van de Kerkhof P, Warren RB, Gottlieb AB, Langley RG, Brock F, Arendt C, Boehnlein M, Lebwohl M, Reich K Tags: Br J Dermatol Source Type: research

Views and experiences of managing eczema: systematic review and thematic synthesis of qualitative studies.
CONCLUSIONS: Effective self-management of eczema could be supported by addressing beliefs and concerns about treatments; seeking positive ways to promote a 'control not cure' message; acknowledging psychosocial impacts of eczema and treatment burden; and providing clear consistent advice or signposting towards reliable information. PMID: 32531800 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 12, 2020 Category: Dermatology Authors: Teasdale E, Muller I, Sivyer K, Ghio D, Greenwell K, Wilczynska S, Roberts A, Ridd MJ, Francis N, Yardley L, Thomas KS, Santer M Tags: Br J Dermatol Source Type: research

QuantiFERON TB-gold conversion is not uncommon in psoriasis patients under anti-TNF- α.
QuantiFERON TB-gold conversion is not uncommon in psoriasis patients under anti-TNF-α. Br J Dermatol. 2020 Jun 12;: Authors: Megna M, Ruggiero A, Ferrillo M, Fabbrocini G Abstract Tuberculosis (TB) screening and eventual TB infection prophylaxis in case of screening positivity for latent TB infection (LTBI) are mandatory before starting a biologic treatment for psoriasis.1 Indeed, opportunistic infections reactivation, especially LTBI, is one the main risk during biologic therapy, in particular with tumour necrosis factor (TNF)-α inhibitors. It is already known that TNFα plays a majo...
Source: The British Journal of Dermatology - June 12, 2020 Category: Dermatology Authors: Megna M, Ruggiero A, Ferrillo M, Fabbrocini G Tags: Br J Dermatol Source Type: research

Clinical predictive factors of unresponsiveness to omalizumab in patients with chronic spontaneous urticaria.
ard F Abstract Chronic spontaneous urticaria (CSU) is an inflammatory disease which is characterized by spontaneous appearance of wheals (hives), angioedema or both for at least six weeks. Approximately 10% of patients suffering from CSU are unresponsive to second-generation H1-antihistamines. For these severe cases, recommendation is a treatment by omalizumab (OMZ) -a humanized anti-IgE monoclonal antibody. However, approximately 20% of patients are still non-responders to OMZ. PMID: 32531805 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 12, 2020 Category: Dermatology Authors: Castagna J, Bernard L, Hacard F, Delcroix F, Darrigade AS, Nicolas JF, Decullier E, Nosbaum A, Bérard F Tags: Br J Dermatol Source Type: research

Burnout in psychodermatology: results from a European survey.
Abstract Burnout is defined as a work-induced syndrome combining emotional exhaustion, depersonalisation and a sense of reduced personal accomplishment. Maslach et al. was the first to provide the definition of burnout as 'a long term, unresolvable stress that leads to exhaustion and feeling overwhelmed, cynical, detached from the job and lacking a sense of personal accomplishment'. PMID: 32526067 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 11, 2020 Category: Dermatology Authors: Gkini MA, Hussain K, Taylor R, Bewley A Tags: Br J Dermatol Source Type: research

What are the barriers to physical activity in patients with chronic plaque psoriasis?
PMID: 32524578 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 10, 2020 Category: Dermatology Authors: Jarrett P Tags: Br J Dermatol Source Type: research

Biologics for psoriasis: what does drug survival tell us?
PMID: 32524579 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 10, 2020 Category: Dermatology Authors: Veysey E Tags: Br J Dermatol Source Type: research

Current measures are not sufficient: an interview-based qualitative assessment of quality of life in cutaneous T-cell lymphoma.
CONCLUSIONS: Incorporating these concerns and priorities that distinguish CTCL patients from other patient populations will be of paramount importance in developing a comprehensive CTCL-specific measure of QoL that adequately captures patients' experience. PMID: 32510571 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 8, 2020 Category: Dermatology Authors: Bhat TS, Herbosa CM, Rosenberg AR, Sogade O, Jeffe DB, Mehta-Shah N, Semenov YR, Musiek AC Tags: Br J Dermatol Source Type: research

What has changed in the UK management of hidradenitis suppurativa from 2014 to 2019?
Abstract A previous survey demonstrated the management of hidradenitis suppurativa (HS) in the UK in 2014 and subsequently, in 2018, the first UK guidelines for the management of HS were published.2 We recently repeated the survey to evaluate whether there has been a change in the management of HS influenced by the guidelines and new HS treatment evidence. PMID: 32510572 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 8, 2020 Category: Dermatology Authors: Hasan SB, Ingram JR Tags: Br J Dermatol Source Type: research

Hyperhidrosis Quality of Life Index (HidroQoL ©): further validation and clinical application in patients with axillary hyperhidrosis using data from a phase III RCT.
Hyperhidrosis Quality of Life Index (HidroQoL©): further validation and clinical application in patients with axillary hyperhidrosis using data from a phase III RCT. Br J Dermatol. 2020 Jun 08;: Authors: Gabes M, Jourdan C, Schramm K, Masur C, Abels C, Kamudoni P, Salek S, Apfelbacher C Abstract BACKGROUND: The Hyperhidrosis Quality of Life Index (HidroQoL©) is a validated patient-reported outcome measure capturing the quality of life of people affected by hyperhidrosis. We aimed to extend the validity evidence to physician-confirmed diagnosis of primary axillary hyperhidrosis. METHODS:...
Source: The British Journal of Dermatology - June 8, 2020 Category: Dermatology Authors: Gabes M, Jourdan C, Schramm K, Masur C, Abels C, Kamudoni P, Salek S, Apfelbacher C Tags: Br J Dermatol Source Type: research

Treatment persistence in paediatric and adolescent psoriasis patients followed into young adulthood: from topical to systemic treatment - a prospective, longitudinal, observational cohort study of 448 patients.
CONCLUSIONS: In a population of paediatric and adolescent psoriasis patients with mild to severe psoriasis, a third needs more intensive treatment than solely topical therapy to control their disease. We consider median time until switch to systemic to be long. PMID: 32510578 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 8, 2020 Category: Dermatology Authors: Bruins FM, Bronckers IMGJ, Cai R, Groenewoud HMM, Krol M, de Jong EMGJ, Seyger MMB Tags: Br J Dermatol Source Type: research

Outcomes for Pressure Ulcer Trials (OUTPUTs) project: review and classification of outcomes reported in pressure ulcer prevention research.
CONCLUSION: A plethora of different outcomes is applied in pressure ulcer prevention research and substantial variations in definitions and reporting of similar outcomes were observed. A COS for pressure ulcer prevention trials is needed to overcome the non-comparability of outcomes. PMID: 32510579 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 8, 2020 Category: Dermatology Authors: Lechner A, Kottner J, Coleman S, Muir D, Beeckman D, Chaboyer W, Cuddigan J, Moore Z, Rutherford C, Schmitt J, Nixon J, Balzer K Tags: Br J Dermatol Source Type: research

Global trends in melanoma mortality differ by sex and age.
PMID: 32515011 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 8, 2020 Category: Dermatology Authors: Olsen CM Tags: Br J Dermatol Source Type: research

Clinical, environmental, and histological distribution of BRAF, NRAS and TERT promoter mutations among cutaneous melanoma patients. A retrospective study of 563 patients.
CONCLUSIONS: The presence of TERT promoter mutations discriminates BRAF and NRAS mutated tumors and indicates a higher involvement of ultraviolet induce damage and tumors with worse melanoma-specific survival than those without any mutation. These observations refine classification of melanoma patients based on mutational status. PMID: 32506424 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 7, 2020 Category: Dermatology Authors: Manrique-Silva E, Rachakonda S, Millán-Esteban D, García-Casado Z, Requena C, Través V, Kumar R, Nagore E Tags: Br J Dermatol Source Type: research

Diagnostic performance of direct immunofluorescence microscopy studies by biopsy sites in autoimmune subepidermal blistering dermatoses: a prospective study.
Abstract The diagnosis of autoimmune subepidermal blistering diseases, such as bullous pemphigoid (BP), critically relies on the detection of tissue-bound immunoreactants along the epidermal basement membrane by direct immunofluorescence microscopy (DIF) studies of skin biopsy specimens obtained from perilesional skin 1,2 . However, there was surprisingly no consensus among international experts about the definition of perilesional skin 1 . The latter was considered as either normal appearing skin surrounding an inflamed area or erythematous skin adjacent to a blister. PMID: 32506435 [PubMed - as supplied by ...
Source: The British Journal of Dermatology - June 7, 2020 Category: Dermatology Authors: Haefliger S, Sitaru S, Cazzaniga S, Rammlmair A, Feldmeyer L, Horn MP, Borradori L Tags: Br J Dermatol Source Type: research

Reduction in skin cancer diagnosis, and overall cancer referrals, during the COVID-19 pandemic.
Abstract The COVID-19 pandemic has led to a marked reduction in the number of patients accessing the UK's National Health Service (NHS) for emergency reasons1 . The cause for this decline is as yet unknown, and likely to be multifactorial. We investigated whether there had been a similar reduction in urgent cancer referrals (known in England as the Two Week Wait (TWW) pathway) and subsequent diagnosis of skin cancer in our dermatology service. PMID: 32500571 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 4, 2020 Category: Dermatology Authors: Earnshaw CH, Hunter HJA, McMullen E, Griffiths CEM, Warren RB Tags: Br J Dermatol Source Type: research

Assessing the need for routine safety testing for patients being treated with dupilumab for moderate-to-severe atopic dermatitis.
Abstract Atopic dermatitis (also known as AD or eczema) is a common skin disease that can cause intense and persistent itching and rashes. Skin creams or ointments are not suitable or effective for some patients with moderate-to-severe AD. In these patients, oral (taken by mouth) or injected medications may be required. Some of those oral or injected treatments could be toxic and often have unwanted side effects, especially when used for a longer period of time, so patients must be regularly tested to see whether those treatments are harming their blood or organs. Dupilumab is a newer injectable drug for treating ...
Source: The British Journal of Dermatology - June 1, 2020 Category: Dermatology Authors: Wollenberg A, Beck LA, Blauvelt A, Simpson EL, Chen Z, Chen Q, Shumel B, Khokhar FA, Hultsch T, Rizova E, Rossi AB, Graham NMH, Pirozzi G, Lu Y, Ardeleanu M Tags: Br J Dermatol Source Type: research

Corrigendum.
Authors: PMID: 32476152 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 1, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

Notice of withdrawal.
Authors: Abstract L. Frommherz, J. Küsel, A. Zimmer, J. Fischer, C. Has. Skin fragility caused by biallelic KRT10 mutations: an intriguing form of self-improving epidermolytic ichthyosis https://onlinelibrary.wiley.com/doi/10.1111/bjd.18325 The above article from the British Journal of Dermatology, published online on 6 July 2019 in Wiley Online Library (wileyonlinelibrary.com), and in print and online in issue 182:3 (cover date March 2020) has been withdrawn by agreement between the authors, the journal's Editor-in-Chief, John Ingram, the British Association of Dermatologists, and John Wiley & Sons Limi...
Source: The British Journal of Dermatology - June 1, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

Publication of national dermatology guidelines as a Research Letter in the BJD: can less ever be enough?
PMID: 32476154 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 1, 2020 Category: Dermatology Authors: van Zuuren EJ, Arents BWM, Flohr C, Ingram JR Tags: Br J Dermatol Source Type: research

miRNA analysis of Childhood Atopic Dermatitis reveals a role for miR-451a.
CONCLUSION: In infants with AD, a distinct peripheral blood miRNA signature is seen, highlighting the systemic effects of the disease. miR-451a is uniquely expressed in different blood compartments of AD patients and may serve as a promising novel biomarker for the early diagnosis of AD. PMID: 32478410 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 1, 2020 Category: Dermatology Authors: Nousbeck J, McAleer MA, Hurault G, Kenny E, Harte K, Kezic S, Tanaka RJ, Irvine AD Tags: Br J Dermatol Source Type: research

Secukinumab shows high and sustained efficacy in nail psoriasis: 2.5-year results from the randomized placebo-controlled TRANSFIGURE study.
CONCLUSIONS: Secukinumab demonstrated strong and clinically meaningful efficacy for up to 2.5 years in nail psoriasis, with significant sustained QoL improvements and a favourable safety profile. PMID: 32479641 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 1, 2020 Category: Dermatology Authors: Reich K, Sullivan J, Arenberger P, Jazayeri S, Mrowietz U, Augustin M, Elewski B, You R, Regnault P, Frueh JA Tags: Br J Dermatol Source Type: research

The challenging management of a series of 43 infants with Netherton syndrome: unexpected complications and novel mutations.
mer C Abstract BACKGROUND: Netherton syndrome (NS) is a rare disease caused by SPINK5 mutations, featuring variable skin and hair involvement and, in many cases, allergic manifestations with a risk of lethality particularly in infants. The clinical management is challenging. OBJECTIVES: To analyse the clinical manifestations of a cohort of NS infants managed in a reference centre. To draw up recommendations for management. METHODS: The inclusion criteria were a management in our reference centre, a histologically or molecularly confirmed diagnosis of NS and available epidemiological, clinical and laborat...
Source: The British Journal of Dermatology - June 1, 2020 Category: Dermatology Authors: Bellon N, Hadj-Rabia S, Moulin F, Lambe C, Lezmi G, Charbit-Henrion F, Alby C, Le Saché-de Peufeilhoux L, Leclerc-Mercier S, Hadchouel A, Steffann J, Hovnanian A, Lapillonne A, Bodemer C Tags: Br J Dermatol Source Type: research

Targeting fear of recurrence: The advantages of assessing psychosocial attributes and psychological dispositions.
Abstract We found the randomized controlled trial of a brief psychological intervention targeting fear of recurrence of melanoma patients by Dieng et al. very interesting. The intervention has been shown to be effective and its implementation in the routine care of melanoma patients seems appropriate. In this regard we have developed some considerations we would like to submit to authors and readers. PMID: 32479645 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 1, 2020 Category: Dermatology Authors: Miniotti M, Ribero S, Leombruni P Tags: Br J Dermatol Source Type: research

First- and third- generation EGFR inhibitors mediate distinct phosphoprotein signalling networks: implications for adverse dermatologic reactions.
Abstract Epidermal growth factor receptor (EGFR) inhibitors are used to treat several malignancies but notoriously exert dermatologic toxicities, reducing patient adherence. Despite targeting the same receptor, different EGFR inhibitors exhibit distinct toxicities. Up to 90% of patients on EGFR inhibitors present with a papulopustular rash, with varying severity and frequency depending on the inhibitor. Some first-generation inhibitors, such as erlotinib and gefitinib, affect hair follicles, resulting in alopecia, hirsutism, and/or trichomegaly. Erlotinib and gefitinib also often elicit pruritus, paronychia, xeros...
Source: The British Journal of Dermatology - June 1, 2020 Category: Dermatology Authors: Vasavda C, Ho BK, Zhang DY, Williams KA, Kaffenberger BH, Kwatra SG, Kwatra MM Tags: Br J Dermatol Source Type: research

Bullous skin disease patients in a high-epidemic COVID-19 area, Bergamo, Italy.
Abstract Bullous pemphigoid (BP) and pemphigus vulgaris (PV) are blistering disorders associated with barrier disruption, immune dysregulation and use of immunosuppressing systemic therapy. Patients with BP and PV have higher potential risk factors for infections secondary to skin alterations, comorbidity and chronic treatment with immunosuppressing agents. PMID: 32479659 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 1, 2020 Category: Dermatology Authors: Carugno A, Sena P, Raponi F, Robustelli Test E, Vezzoli P Tags: Br J Dermatol Source Type: research

Treatment of early-stage mycosis fungoides: results from the PROspective Cutaneous Lymphoma International Study (PROCLIPI study).
shalko M, Mitteldorf C, Akilov O, Ortiz-Romero P, Estrach T, Vakeva L, Enz PA, Wobser M, Bayne M, Jonak C, Rubeta M, Forbes A, Bates A, Battistella M, Amel-Kashipaz R, Vydianath B, Combalia A, Georgiou E, Hauben E, Hong EK, Jost M, Knobler R, Amitay-Laish I, Miyashiro D, Cury-Martins J, Martinez X, Muniesa C, Prag-Naveh H, Nikolaou V, Quint K, Ram-Wolff C, Rieger K, Stranzenbach R, Szepesi Á, Alberti-Violetti S, Felicity E, Cerroni L, Kempf W, Whittaker S, Willemze R, Kim Y, Scarisbrick JJ Abstract BACKGROUND: The PROspective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) Study is a prospectiv...
Source: The British Journal of Dermatology - June 1, 2020 Category: Dermatology Authors: Quaglino P, Prince HM, Cowan R, Vermeer M, Papadavid L, Bagot M, Servitjie O, Berti E, Guenova E, Stadler R, Querfeld C, Busschots AM, Hodak E, Patsatsi A, Sanches J, Maule M, Yoo J, Kevin M, Fava P, Ribero S, Zocchi L, Rubatto M, Fierro MT, Wehkamp U, Ma Tags: Br J Dermatol Source Type: research

Cutaneous manifestations in patients with COVID-19: A preliminary review of an emerging issue.
CONCLUSIONS: The possible presence of cutaneous findings leading to suspect COVID-19 puts dermatologists in a relevant position. Further studies are needed to delineate the diagnostic and prognostic value of such cutaneous manifestations. PMID: 32479680 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 1, 2020 Category: Dermatology Authors: Marzano AV, Cassano N, Genovese G, Moltrasio C, Vena GA Tags: Br J Dermatol Source Type: research

First real-world data provide evidence for a 'window of opportunity' in treatment of hidradenitis suppurativa/acne inversa.
PMID: 32476130 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 31, 2020 Category: Dermatology Authors: Zouboulis CC Tags: Br J Dermatol Source Type: research

Assessment of patient knowledge and completion of advance directives in oncodermatology.
Abstract Advance directives (AD) are the possibility for any individual to express their wishes on how to be cared at the end of life, when they can no longer make the decisions themselves. In France, AD are only applicable during the end-of-life period, such as after an irrecoverable accident or at a terminal phase of a disease. It appeared for the first time in France in 2005 with the Léonetti law, which discussed matters related to the end of life. PMID: 32473026 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 30, 2020 Category: Dermatology Authors: Melgar E, Escobar GF, Granel-Brocard F, Remen T, Marzouki-Zerouali A, Geoffrois L, Martin H, Schoeffler A, Schmutz JL, Bursztejn AC Tags: Br J Dermatol Source Type: research

Risk of keratinocyte carcinoma among patients with hidradenitis suppurativa.
Abstract Hidradenitis suppurativa (HS), also known as acne inversa, is a chronic inflammatory disorder of the pilosebaceous units. To date, studies on the risk of keratinocyte carcinoma (KC), defined as basal cell carcinoma (BCC) and squamous cell carcinoma (SCC), among HS patients have been limited. We performed a case-control study comparing the incidence of BCC and SCC in HS patients (cases) to that in acne vulgaris patients (controls), which is also an inflammatory disorder of the pilosebaceous unit. PMID: 32473027 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 30, 2020 Category: Dermatology Authors: Ashrafzadeh S, Kim Y, Peters GA, Lee H, Asgari MM Tags: Br J Dermatol Source Type: research

Are all Buruli ulcers caused by Mycobacterium ulcerans?
an RE Abstract Buruli ulcer (BU) is the third most common mycobacterial disease worldwide and affects mainly poor human populations living in tropical and subtropical areas. In 2018, Africa and Australia reported the most cases (2335 and 358 cases, respectively), followed by French Guiana (FG, 5 cases) and Japan (3 cases). Clinical signs of the disease include painless nodules, plaques and edema followed by the development of skin ulcers. PMID: 32470150 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 29, 2020 Category: Dermatology Authors: Combe M, Couppié P, Blaizot R, Valentini A, Gozlan RE Tags: Br J Dermatol Source Type: research

Does mitochondrial dysfunction of hair follicle epithelial stem cells play a role in the pathobiology of lichen planopilaris?
Abstract Lichen planopilaris (LPP) is a difficult to treat condition leading to permanent hair loss and scarring. Pathobiologically, LPP shows T- cell mediated interferon-γ driven loss of keratin 15 (K15) positive hair follicle (HF) epithelial stem cells (eHFSCs) due to immune privilege (IP) collapse and pathological epithelial-mesenchymal transition (EMT). This exhausts the eHFSC pool; impacting the HF's capacity to regenerate and cycle and ultimately resulting in HF destruction, fibrosis and scarring. PMID: 32471007 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 29, 2020 Category: Dermatology Authors: Hardman-Smart JA, Purba TS, Panicker S, Farjo B, Farjo N, Harries MJ, Paus R Tags: Br J Dermatol Source Type: research

Absence of Skin of Colour Images in Publications of COVID-19 Skin Manifestations.
Abstract There are now over 1 million confirmed cases of COVID-19 globally with more than 270,000 recorded deaths to date. COVID-19 has been shown to disproportionately impact people of colour both in the United Kingdom and in the United States where blacks make up 13.4% of the population but 30% of COVID-19 cases. Mounting evidence shows that COVID-19 impacts several organ systems, including the skin. PMID: 32471009 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 29, 2020 Category: Dermatology Authors: Lester JC, Jia JL, Zhang L, Okoye GA, Linos E Tags: Br J Dermatol Source Type: research

Outcome domains in Lichen Sclerosus.
Abstract Lichen Sclerosus (LS) is a chronic inflammatory dermatosis predominantly affecting the genitals. It can affect men, women and children. LS affecting female genitalia typically presents with itchy patches that impact on physical and psychosocial-sexual functioning1,2 . Symptoms in men include difficulty urinating due to urethral narrowing, difficulty in foreskin retraction due to scarring, and dyspareunia. Complications include loss of anatomy and malignant transformation. PMID: 32471015 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 29, 2020 Category: Dermatology Authors: Goodrum CA, Leighton PA, Simpson RC Tags: Br J Dermatol Source Type: research

Virtual melanoma checks during a pandemic.
Abstract Healthcare services internationally are experiencing unprecedented strain due to the COVID-19 pandemic. Governments mandate strict social distancing to reduce the spread of SARS-CoV-2 infection, and as a result, people are avoiding health services for less urgent issues. In this crisis, it is important that patients continue to receive preventive and surveillance care without compromising their safety or that of healthcare workers. PMID: 32471016 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 29, 2020 Category: Dermatology Authors: Janda M, Swetter SM, Horsham C, Soyer HP Tags: Br J Dermatol Source Type: research

Further evidence that chilblains are a cutaneous manifestation of COVID-19 infection.
Abstract A range of cutaneous conditions including chilblain-like lesions have been reported in patients with Coronavirus 2019 (COVID-19) due to severe acute respiratory Syndrome coronavirus 2 (SARS-Cov-2). Using clinical data and images, the authors of a recent nationwide Spanish survey identified 5 clinical patterns which were associated with different patient demographics, onset (timing), and prognosis. PMID: 32460349 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 27, 2020 Category: Dermatology Authors: Hughes M, Rogers S, Lepri G, Bruni C, Matucci-Cerinic M Tags: Br J Dermatol Source Type: research

Reliability and validity of the Vitiligo Signs of Activity Score.
PMID: 32458411 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 26, 2020 Category: Dermatology Authors: Eleftheriadou V Tags: Br J Dermatol Source Type: research

The value of ongoing surveillance on the prevalence of contact sensitization.
PMID: 32458421 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 26, 2020 Category: Dermatology Authors: Schuttelaar MLA Tags: Br J Dermatol Source Type: research

Is targeting circulating T blood cells a therapeutic option for vitiligo?
PMID: 32458433 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 26, 2020 Category: Dermatology Authors: Matos TR Tags: Br J Dermatol Source Type: research

Meta-analysis results do not reflect the real safety of biologics in psoriasis.
CONCLUSION: On excluding cases of worsening psoriasis, the risk of occurrence of SAEs is higher in the biological than in the placebo arm. Given the rare events, we could not highlight whether this higher risk of SAEs was related to AEs of special interest. Reporting of SAEs in clinical trials has to be changed to provide more transparency through the separate reporting of disease flares leading to hospital admission and other SAEs. PMID: 32446286 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 23, 2020 Category: Dermatology Authors: Afach S, Chaimani A, Evrenoglou T, Penso L, Brouste E, Sbidian É, Le Cleach L Tags: Br J Dermatol Source Type: research

Dimethyl fumarate modulates the Treg:Th17 cell axis in psoriasis patients.
CONCLUSIONS: DMF enhanced the ratio of Treg:Th17 cells both in psoriasis patients, multiple sclerosis patients and in vitro. Furthermore, our data suggest that this is at least in part as a result of the differential effects of DMF on Treg compared with T conventional cells. PMID: 32438447 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 21, 2020 Category: Dermatology Authors: Sulaimani J, Cluxton D, Clowry J, Petrasca A, Molloy OE, Moran B, Sweeney CM, Malara A, McNicholas N, McGuigan C, Kirby B, Fletcher JM Tags: Br J Dermatol Source Type: research

Average daily itch versus worst daily itch in chronic itch evaluation.
Abstract Chronic itch can be a debilitating medical condition with clinical characteristics and impact akin to chronic pain. Itch severity is subjective and clinicians depend on patient reported numerical ratings scales (NRS); most commonly 24-hour worst itch (WI-NRS) has been validated including large scale studies. WI-NRS does not attempt to take into account itch duration or the variability that is often experienced throughout the day and night by chronic itch patients. PMID: 32438472 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 21, 2020 Category: Dermatology Authors: Fourzali KM, Golpanian S, Chan YH, Yosipovitch G Tags: Br J Dermatol Source Type: research

Prevalence of hidradenitis suppurativa is one percent of the population of Wales using the Secure Anonymised Information Linkage (SAIL) Databank.
Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with multiple inflammatory skin lesions ('boils') in flexural locations.1 Prevalence of HS remains controversial2,3 and the study aim was to search the Secure Anonymous Information Linkage (SAIL) Databank to identify diagnosed and undiagnosed HS cases in Wales, UK. PMID: 32433788 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 20, 2020 Category: Dermatology Authors: Ingram JR, Collins H, Atkinson MD, Brooks CJ Tags: Br J Dermatol Source Type: research

A Phase 2, randomized, double-blind, placebo-controlled, dose-ranging study to evaluate the efficacy and safety of VT-1161 oral tablets in the treatment of patients with distal and lateral subungual onychomycosis of the toenail.
Abstract BACKGROUND: Onychomycosis is a fungal disease that affects the fingernails and toenails and is predominantly caused by dermatophytes. VT-1161 is a novel inhibitor of fungal CYP51 through the inhibition of the lanosterol demethylase, and has demonstrated potent activity against T. rubrum and T. mentagrophytes. OBJECTIVE: To evaluate the safety and efficacy of four dosing regimens of orally-administered VT-1161 compared with placebo in patients with moderate to severe distal and lateral subungual onychomycosis of the toenail. METHOD: A Phase 2, randomized, double-blind, placebo-controlled, multice...
Source: The British Journal of Dermatology - May 18, 2020 Category: Dermatology Authors: Elewski B, Brand S, Degenhardt T, Curelop S, Pollack R, Schotzinger R, Tavakkol A Tags: Br J Dermatol Source Type: research