Retrospective Cohort Study of Pregnancy Outcomes in Hidradenitis Suppurativa.
The objective of this study was to examine pregnancy complications, pregnancy outcomes, and neonatal outcomes in patients with HS. PMID: 32333790 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 24, 2020 Category: Dermatology Authors: Lyons AB, Peacock A, McKenzie SA, Jacobsen G, Naik HB, Shi VY, Hamzavi IH, Hsiao JL Tags: Br J Dermatol Source Type: research

Protective effects of dietary fish-oil supplementation on skin inflammatory and oxidative stress biomarkers induced by fine particulate air pollution: A pilot randomised, double-blind, placebo-controlled trial.
CONCLUSIONS: This study suggested that dietary fish-oil supplementation may improve biomarkers of skin inflammation and oxidative-stress response to short-term PM2.5 exposure. PMID: 32333793 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 24, 2020 Category: Dermatology Authors: Lin Z, Niu Y, Jiang Y, Chen B, Peng L, Mi T, Huang N, Li W, Xu D, Chen R, Kan H Tags: Br J Dermatol Source Type: research

Clinical forensic dermatology in cases of torture.
Abstract In many European countries the number of asylum seekers has increased in parallel with increasing numbers of migrants and refugees. Recent experiences in providing medical assessment, care and corroborating evidence for people seeking asylum in France motivated us to review the basic principles of forensic dermatology, an essential skill for the attribution of skin lesions to different mechanisms of torture and for proposing appropriate diagnosis. PMID: 32333802 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 24, 2020 Category: Dermatology Authors: Deps P, Collin SM, Aborghetti HP, Charlier P Tags: Br J Dermatol Source Type: research

Epitope competition and neutralizing antidrug antibodies: immune monitoring of antiprogrammed death-1 therapies and lessons learned from natalizumab.
r P Abstract We read with interest the BJD online publication by Gambichler and colleagues1 about a decline of programmed death (PD)-1+ circulating T regulatory cells (Tregs) predicting clinical outcome in anti-PD-1 therapy. The study highlights the potential and importance of immune monitoring in anti-PD-1 checkpoint therapy in malignant melanoma. However, their conclusion about anti-PD-1 antibody treatment effecting a decline of PD-1+ Tregs is misleading. PMID: 32319671 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 21, 2020 Category: Dermatology Authors: Harrer A, Lang R, Kölblinger P Tags: Br J Dermatol Source Type: research

High somatostatin receptor expression and efficacy of somatostatin analogues in patients with metastatic Merkel cell carcinoma.
CONCLUSIONS: In contrast to other high-grade NETs, mMCC tumours appear to frequently express SSTR. SSA can lead to clinically meaningful disease control with minimal side effects. SSTR targeting using SSA or other novel approaches should be explored further for mMCC. PMID: 32320473 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 21, 2020 Category: Dermatology Authors: Akaike T, Qazi J, Anderson A, Behnia FS, Shinohara M, Akaike G, Hippe DS, Thomas H, Takagishi SR, Lachance K, Park SY, Tarabadkar ES, Iyer JG, Blom A, Parvathaneni U, Vesselle H, Nghiem P, Bhatia S Tags: Br J Dermatol Source Type: research

Feasibility and healthcare costs of superpotent topical corticosteroid therapy in bullous pemphigoid: a prospective, observational study in an academic center in France.
The objectives of this study were to determine whether TCS alone were actually used as first-line therapy and could be successfully continued during the first year of treatment in routine practice, and to estimate the related healthcare costs. PMID: 32320476 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 21, 2020 Category: Dermatology Authors: Clapé A, Muller C, Plée J, Viguier M, Vanhaecke C, Bernard P Tags: Br J Dermatol Source Type: research

Sleep disturbance in atopic dermatitis: a case-control study using actigraphy and smartphone-collected questionnaires.
This study aimed to evaluate the sleep of patients with AD and to compare it with that of healthy volunteers using wrist actigraphy and a smartphone application. PMID: 32320479 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 21, 2020 Category: Dermatology Authors: Jachiet M, Bieuvelet S, Argoud AL, Vallée M, Zinaï S, Lejeune FX, Leger D, Bouaziz JD, Elbaz M, Bagot M Tags: Br J Dermatol Source Type: research

Global evidence on occupational sun exposure and keratinocyte cancers: a systematic review.
Abstract Individual studies have suggested that the association between occupational exposure to solar ultraviolet radiation (UVR) and the development of keratinocyte cancers (KC) may only be valid in populations of European ancestry living in certain geographic regions. Comparative global data are scarce and so this review aimed to summarize current evidence on the association between occupational exposure to solar UVR and the development of KC, with a specific focus on geographic location and skin colour. Ovid Medline, PubMed, EMBASE, and Web of Science were searched for potentially relevant records. Extracted d...
Source: The British Journal of Dermatology - April 21, 2020 Category: Dermatology Authors: Loney T, Paulo MS, Modenese A, Gobba F, Tenkate T, Whiteman DC, Green AC, John SM Tags: Br J Dermatol Source Type: research

Partner bereavement can increase the incidence of atopic dermatitis but has no effect on psoriasis.
PMID: 32323301 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 21, 2020 Category: Dermatology Authors: von Kobyletzki LB Tags: Br J Dermatol Source Type: research

Silicone dressings for pressure ulcer prevention.
PMID: 32323310 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 21, 2020 Category: Dermatology Authors: Nixon J Tags: Br J Dermatol Source Type: research

Efficacy and Safety of Ixekizumab in a Phase 3, Randomized, Double-Blind, Placebo-Controlled Study in Paediatric Patients with Moderate-to-Severe Plaque Psoriasis (IXORA-PEDS).
group Abstract BACKGROUND: Plaque psoriasis affects children and adults, but treatment options for paediatric psoriasis are limited. OBJECTIVES: Evaluate the efficacy and safety of ixekizumab (IXE), a high-affinity monoclonal antibody that selectively targets interleukin-17A, for moderate-to-severe paediatric psoriasis. METHODS: In a randomised, double-blind, placebo-controlled, Phase 3 study (IXORA-PEDS), patients (age 6 to
Source: The British Journal of Dermatology - April 20, 2020 Category: Dermatology Authors: Paller AS, Seyger MMB, Magariños GA, Bagel J, Pinter A, Cather J, Keller S, Capriles CR, Lima RG, Gallo G, Little CA, Edson-Heredia E, Li L, Xu W, Papp K, IXORA-PEDS study group Tags: Br J Dermatol Source Type: research

Treatment of hereditary palmoplantar keratoderma: a review by analysis of the literature.
Abstract No specific or curative therapy exists for hereditary Palmoplantar Keratoderma (hPPK) which can profoundly alter patient quality of life, leading sometimes to severe functional impairment and pain. The rarity and the aetiological diversity of this group of disorders can explain the difficulty in comparing the efficacy of available treatments. Our objective was to review the different treatments tried in hPPK patients since 2008, their efficacy and safety, with an evaluation of the various therapeutic modalities that can be used to treat hPPK . We realized a comprehensive review of the literature data publ...
Source: The British Journal of Dermatology - April 19, 2020 Category: Dermatology Authors: Bodemer C, Steijlen P, Hautier JM, O'Toole EA Tags: Br J Dermatol Source Type: research

Mapping the burden of onchocercal skin disease.
Abstract Onchocerciasis is a neglected tropical disease caused by a nematode parasite, Onchocerca volvulus, and transmitted by bites of Simulium blackflies which breed near fast-flowing rivers. In humans thousands of microfilariae (immature worms) migrate to the skin and eyes where they cause pathology. Historically, much research was devoted to the serious effect of blindness, from which the disease earns its alternative name of "river blindness". Mapping the burden of onchocercal skin disease (OSD) was expedited by the development of a clinical classification and grading system which facilitated compar...
Source: The British Journal of Dermatology - April 16, 2020 Category: Dermatology Authors: Murdoch ME Tags: Br J Dermatol Source Type: research

Phototherapeutic approach to dermatological patients during the 2019 Coronavirus pandemic: Real-life Data from the Italian Red Zone.
one A Abstract Since the novel Coronavirus 2019, also known as COVID-19 or SARS CoV-2, crossed the Chinese borders and became pandemic, Italy has rapidly become the country with the highest number of patient deaths as well as confirmed and/or hospitalized patients, after China [1-2]. On March 12th Italy was declared a red-zone and special protocols were enacted to limit the spread of the virus. Although COVID-19 does not have epidermotropism, cutaneous manifestations in Cov-19 positive patients have been reported [3] and departments of dermatology are considered at high risk [4] and were ordered to admit only pati...
Source: The British Journal of Dermatology - April 16, 2020 Category: Dermatology Authors: Pacifico A, Ardigò M, Frascione P, Damiani G, Morrone A Tags: Br J Dermatol Source Type: research

Hidradenitis suppurativa publications are sparse in front-line specialties.
Abstract Hidradenitis suppurativa (HS) is a debilitating inflammatory disease that is understudied, underfunded, and notable for mean diagnostic delay of approximately 7 years. We aimed to characterize annual HS-related publications across medical fields of study caring for HS in order to measure the extent of awareness, education and ongoing research in this area. PMID: 32294228 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 14, 2020 Category: Dermatology Authors: Martins DB, Ayanruoh L, Paul M, Shukla N, Naik HB Tags: Br J Dermatol Source Type: research

Leptin induces interleukin-6 production in keratinocytes via decreased expression of caveolin-1: a possible link between obesity and psoriatic inflammation.
Abstract It has been reported that obesity may be an aggravating factor for psoriasis. However, its pathological mechanism remains elusive. The adipocyte-derived hormone leptin primarily controls energy homeostasis by regulating appetite and modulates immunity. Strikingly, serum leptin levels are elevated in obese patients and positively correlate with body mass index. Additionally, leptin levels also correlate with severity of psoriasis, and knocking out leptin suppresses imiquimod-induced psoriatic inflammation in mice. PMID: 32294231 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 14, 2020 Category: Dermatology Authors: Watanabe Y, Yamaguchi Y, Takamura N, Komitsu N, Aihara M Tags: Br J Dermatol Source Type: research

Cost and Diagnostic Characteristics of Toxicodendron Dermatitis in the United States: A retrospective cross-sectional analysis.
Abstract Toxicodendron dermatitis (TD), or allergic contact dermatitis (ACD) due to poison ivy, oak, and sumac, is the most common cause of ACD in the United States (US). Affecting 10-15 million people every year, TD causes a pruritic, erythematous rash 24-48 hours following skin contact with urushiol, the compound found on poison ivy, oak, and sumac plants responsible for producing an allergic response. PMID: 32294234 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 14, 2020 Category: Dermatology Authors: Zomorodi N, Butt M, Maczuga S, Marks J, Flamm A Tags: Br J Dermatol Source Type: research

High and discordant prevalences of clinical and sonographic enthesitis in patients with hidradenitis suppurativa.
Abstract The prevalence of spondyloarthritis (SpA) reported among patients with hidradenitis suppurativa (HS) ranges from 2.3 to 28.2 %, depending on the diagnostic method used.1 A key feature of SpA and one of the European Spondyloarthropathy Study Group (ESSG) diagnostic criteria for this group of diseases is enthesitis; inflammation at insertion of tendons, ligaments, and capsules. However, pain at an entheseal site is non-specific and does not always indicate inflammation. PMID: 32294241 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 14, 2020 Category: Dermatology Authors: van Straalen KR, Boeren AMP, Wervers K, Prens E, Vis M Tags: Br J Dermatol Source Type: research

Disease characteristics in female and male Patients with Hidradenitis Suppurativa.
en SF Abstract The continuously growing interest in the study of gender medicine in the last years has led to increased awareness of the differences between men and women in the clinical presentation, pathophysiology, management, and prognosis of a wide variety of diseases, including skin diseases. Gender differences in disease characteristics can be influenced by numerous factors, e.g. the effect of sex hormones, anatomy, physiology, and genetics. Variances in skin structure and physiology between the sexes can also contribute to different expressions of certain skin disorders. PMID: 32294242 [PubMed - as su...
Source: The British Journal of Dermatology - April 14, 2020 Category: Dermatology Authors: Jørgensen AR, Ring HC, Yao Y, Thomsen SF Tags: Br J Dermatol Source Type: research

Dapsone therapy for hidradenitis suppurativa.
Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory condition of apocrine gland-bearing skin that is characterised by recurrent painful nodules, abscess and sinus tract formation. Estimates of the prevalence of HS are highly variable, but it is believed to affect around 1% of the population in Europe. Existing treatments for HS include antimicrobial, immunomodulatory and immunosuppressive agents. PMID: 32294243 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 14, 2020 Category: Dermatology Authors: Murray G, Hollywood A, Kirby B, Hughes R Tags: Br J Dermatol Source Type: research

Treatment of severe cutaneous adverse reaction with tocilizumab.
Abstract A 29-year-old Chinese male with recurrent alveolar soft part sarcoma of the tongue metastatic to lung presented with fever and rash (Figure 1a). He underwent glossectomy and adjuvant radiotherapy, complicated by recurrence and abscess with sinus tract formation on the right neck. Current therapy included ipilimumab 3mg/kg and nivolumab 1mg/kg (completed 9 cycles; last dose two days before admission), and cabozantinib 40mg daily (held for six weeks due to sinus tract in the neck). PMID: 32291751 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 13, 2020 Category: Dermatology Authors: Hibler BP, Markova A Tags: Br J Dermatol Source Type: research

Long-term efficacy and safety of brodalumab in psoriasis through 120 weeks and after withdrawal and retreatment: subgroup analysis of a randomised phase 3 trial (AMAGINE-1).
CONCLUSIONS: These findings indicate that brodalumab is efficacious and safe for continuous long-term treatment of psoriasis and support potential for response after discontinuation and retreatment. PMID: 32286683 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 13, 2020 Category: Dermatology Authors: Papp K, Menter A, Leonardi C, Soung J, Weiss S, Pillai R, Jacobson A Tags: Br J Dermatol Source Type: research

Choosing a biologic for psoriasis: is it a sprint or a marathon?
PMID: 32285438 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Veysey E Tags: Br J Dermatol Source Type: research

Nivolumab-induced toxic epidermal necrolysis with retiform purpura.
PMID: 32281097 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Basu P, Tong Y, Hinds BR, Schneider JA Tags: Br J Dermatol Source Type: research

What's in? What's out? Updating the British Society for Cutaneous Allergy Facial Series.
CONCLUSION: This audit has highlighted the significant variation in practice that exists amongst patch test centres, despite a recommended facial series. The BSCA facial series has been updated and now contains 24 allergens. Fifteen allergens remain, 11 allergens have been dropped and 9 new allergens have been added. PMID: 32282055 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Rolls S, Owen E, Bertram CG, Bourke JF, Buckley DA, Chowdhury MMU, Cooper SM, Ghaffar SA, Green CM, Hughes TM, Johnston GA, Reckling CM, Thompson DA, Wakelin SH, Wilkinson M, Stone NM Tags: Br J Dermatol Source Type: research

Partner bereavement and risk of chronic urticaria, alopecia areata and vitiligo: cohort studies in the United Kingdom and Denmark.
In this study, we further investigated whether partner bereavement was associated with urticaria, alopecia areata, or vitiligo. PMID: 32282926 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Wong AYS, Kjaersgaard A, Frøslev T, Forbes HJ, Mansfield KE, Silverwood RJ, Sørensen HT, Smeeth L, Schmidt SAJ, Langan SM Tags: Br J Dermatol Source Type: research

The prognostic impact of the extent of ulceration in clinical stage I-II melanoma patients: A multicenter study of the Italian Melanoma Intergroup (IMI).
CONCLUSION: This study demonstrated that EU has an independent prognostic impact in PCM and should be recorded as a required element in pathology reports. PMID: 32282932 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Portelli F, Galli F, Cattaneo L, Cossa M, De Giorgi V, Forte G, Fraternali Orcioni G, Gianatti A, Indini A, Labianca A, Maurichi A, Merelli B, Montesco MC, Occelli M, Patuzzo R, Piazzalunga D, Pigozzo J, Quaglino P, Ribero S, Salvatori R, Saraggi D, Sena Tags: Br J Dermatol Source Type: research

Dermatologic adverse events associated with use of oral mechanistic target of rapamycin inhibitors in a cohort of individuals with tuberous sclerosis complex.
Abstract Systemic inhibitors of mechanistic target of rapamycin (mTOR) have antiproliferative, antiangiogenic, and immunosuppressive properties. In dermatology, they are effective for managing certain vascular anomalies and genodermatoses, notably tuberous sclerosis complex (TSC).1 Compared to cancer patients or transplant recipients, TSC patients are prescribed mTOR inhibitors at lower doses and their treatment regimens are less likely to include other drugs that may induce similar side effects. PMID: 32282933 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Pithadia DJ, Treichel AM, Jones AM, Julien-Williams P, Machado T, Moss J, Darling TN Tags: Br J Dermatol Source Type: research

Intervention Study to Evaluate the Importance of Information Given to Patients with Contact Allergy. A randomized, investigator-blinded clinical trial.
CONCLUSION: The performed intervention did not significantly affect the participants' ability to remember their contact allergy. To achieve better knowledge and changes in lifestyle, efforts to inform should concentrate on individuals with several positive patch test reactions, those with particular allergens, individuals over 60 years of age, and-concerning changes in lifestyle-males. PMID: 32282934 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Dizdarevic A, Troensegaard W, Uldahl A, Bergendorff O, Siemund I, Svensson Å, Sonesson A Tags: Br J Dermatol Source Type: research

Identification of a founder mutation in KRT14 associated with Naegeli-Franceschetti-Jadassohn-syndrome.
z RC Abstract Naegeli-Franceschetti-Jadassohn syndrome (NFJS; Mendelian Inheritance in Man (MIM) 161000) is a rare, autosomal-dominant ectodermal dysplasia.1 Affected individuals present with a heterogenous spectrum of ectodermal abnormalities. The most distinctive features are absent dermatoglyphics, reticulate hyperpigmentation of the skin, palmoplantar keratoderma, and decreased sweating. Other features may include abnormalities of the teeth, hair, nails, and skin. PMID: 32282935 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Ralser DJ, Kumar S, Borisov O, Sarig O, Richard G, Wolf S, Krawitz PM, Sprecher E, Kreiß M, Betz RC Tags: Br J Dermatol Source Type: research

Molecular subtype, biological sex and age shape melanoma tumour evolution.
CONCLUSIONS: These data indicate the contribution of environmental damage to melanoma likely extends beyond genetic damage to affect cell division. Sex and age determine the final mutational composition of melanoma. PMID: 32282938 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Lotz M, Budden T, Furney SJ, Virós A Tags: Br J Dermatol Source Type: research

Novel nicastrin mutation in hidradenitis suppurativa-Dowling Degos disease clinical phenotype: more than just clinical overlap?
Abstract In familial hidradenitis suppurativa (HS), mutations in the genes encoding three subunits of the -secretase complex, PSEN1, PSENEN and NCSTN, have pointed to an impaired NOTCH signalling as a pathogenic disease mechanism.1 Dowling Degos Disease (DDD; MIM 179850, 615327, and 615696)-a rare reticulated pigmentary disorder- has also been associated with a deficient NOTCH signalling and patients with mutations in PSENEN suffering from both disorders seem to confirm a potential link between two apparently different conditions. PMID: 32282940 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Garcovich S, Tricarico PM, Meddour CN, Giovanardi G, Peris K, Crovella S, Boniotto M Tags: Br J Dermatol Source Type: research

Allergic contact dermatitis to non-methacrylate nail allergens in the UK.
Abstract The soaring demand for acrylic nails has resulted in a rapid increase in the frequency of allergic contact dermatitis (ACD) to (meth)acrylates1,2 . However, traditional nail varnish remains widely used. Nail varnish is a mixture of film formers and include nitrocellulose, adipic acid/neopentyl glycol/trimellitic anhydride copolymer (AA), and phthalic anhydride/trimellitic anhydride/glycols copolymer (PA). PMID: 32275769 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 9, 2020 Category: Dermatology Authors: Eleftheriadou V, Roche L, Bourke JF, Buckley DA, Orton DI, Stone NM, Wilkinson SM, Thompson DA, Johnston GA Tags: Br J Dermatol Source Type: research

Adenopathy and extensive skin patch overlying a plasmacytoma (AESOP) syndrome: erythrocyanotic vascular patches associated with an underlying rib plasmacytoma.
PMID: 32270486 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 8, 2020 Category: Dermatology Authors: Afra TP, Namitha R, Khader A, Bishnoi A, Shahul Hameed DK, Razmi T M Tags: Br J Dermatol Source Type: research

A mosaic variant in MAP2K1 is associated with giant naevus-spilus type congenital melanocytic naevus and melanoma development.
Abstract Giant congenital melanocytic naevi (CMN) arise primarily due to postzygotic mutations in NRAS, and are of clinical importance due to their increased risk of malignant transformation.1 A subtype of large CMN, termed naevus spilus (NS)-type CMN, is identified by the presence of a patch which may have café-au-lait pigmentation and superimposed macular or papular lesions, which are demonstrably melanocytic naevi on histology. PMID: 32271937 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 8, 2020 Category: Dermatology Authors: Muthiah S, Polubothu S, Husain A, Oliphant T, Kinsler VA, Rajan N Tags: Br J Dermatol Source Type: research

New effects of caffeine on CRH-induced stress along the intrafollicular classical HPA-axis (CRH-R1/2, IP3 -R, ACTH, MC-R2) and the neurogenic non-HPA-axis (substance P, p75NTR and TrkA) in ex vivo human male androgenetic scalp hair follicles.
Abstract Human hair is highly responsive to stress, and human scalp hair follicles (HFs) contain a peripheral neuro-endocrine equivalent of the systemic hypothalamic-pituitary-adrenal (HPA) stress axis. Androgenetic alopecia (AGA) is supposed to be aggravated by stress. We used the HPA axis triggering corticotropin-releasing hormone (CRH) to induce a stress response in human ex vivo male AGA HFs. Furthermore, since caffeine is known to reverse testosterone-mediated hair growth inhibition in the same hair organ culture model, we investigated whether caffeine would antagonize CRH-mediated stress in these HFs. HFs fr...
Source: The British Journal of Dermatology - April 8, 2020 Category: Dermatology Authors: Fischer TW, Bergmann A, Kruse N, Kleszczynski K, Skobowiat C, Slominski AT, Paus R Tags: Br J Dermatol Source Type: research

The use of tissue-engineered skin to demonstrate the negative effect of CXCL5 on epidermal UV radiation-induced CPD repair efficiency.
CONCLUSIONS: This work outlines the impact of the secreted dermal components on epidermal UVR-induced DNA damage repair and shed light on a novel role of CXCL5 in CPD repair. PMID: 32271940 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 8, 2020 Category: Dermatology Authors: Dorr MM, Guignard R, Auger FA, Rochette PJ Tags: Br J Dermatol Source Type: research

Adverse Skin Reactions Among Healthcare Workers During the Coronavirus Disease 2019 Outbreak: A Survey in Wuhan and Its Surrounding Regions.
Abstract During the outbreak of coronavirus disease 2019 (COVID-19), healthcare workers (HCWs) caring for COVID-19 patient have to wear personal protective equipment (PPE) and are therefore susceptible to PPE-related adverse skin reactions. However, little is known about the prevalence and characteristics of these adverse skin reactions and their associated risk factors. PMID: 32255197 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 6, 2020 Category: Dermatology Authors: Lin P, Zhu S, Huang Y, Li L, Tao J, Lei T, Song J, Liu D, Chen L, Shi Y, Jiang S, Liu Q, Xie J, Chen H, Duan Y, Xia Y, Zhou Y, Mei Y, Zhou X, Wu J, Fang M, Meng Z, Li H Tags: Br J Dermatol Source Type: research

The patient knows best: a new self-reported outcome measure for systemic sclerosis.
PMID: 32253751 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 5, 2020 Category: Dermatology Authors: Clark KEN, Denton CP Tags: Br J Dermatol Source Type: research

Drawstring papules in an Indian woman.
PMID: 32253758 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 5, 2020 Category: Dermatology Authors: Rajan MB, Budania A, Vishwajeet V Tags: Br J Dermatol Source Type: research

Cash is king: the balance of costs and effectiveness of treatments for actinic keratosis.
PMID: 32249410 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 4, 2020 Category: Dermatology Authors: Steeb T, Heppt MV, Berking C Tags: Br J Dermatol Source Type: research

Magnolol induces adipogenic differentiation in human skin.
Abstract The skin adipose tissue participates in energy storage, thermogenesis, endocrine secretion, fibrosis and scarring, and innate immune defense.1 Furthermore, the facial subcutaneous fat is important for skin aging such as elasticity and wrinkle formation.2,3 The subcutaneous layer as well as epidermal-dermal layer is modified with age through changes in its thickness, preadipocytes' differentiation, and size of adipocytes.4 It has been established that the age-dependent changes of fat layer are associated with our health, body shape and skin condition including metabolic diseases, obesity, and facial aging....
Source: The British Journal of Dermatology - April 4, 2020 Category: Dermatology Authors: Kim MS, Lee S, Park SB, Kim KY, Kim Y, Kang HY, Park SG, Kang NG Tags: Br J Dermatol Source Type: research

Stratifying clinical response to adjuvant platelet-rich plasma in androgenetic alopecia patients.
The objective of this study is to determine if AGA patient response to adjuvant PRP can be stratified based on quantitative hair counts after two treatment sessions. PMID: 32248528 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 4, 2020 Category: Dermatology Authors: Juhasz MLW, Sukhdeo K, Lo Sicco K, Shapiro J Tags: Br J Dermatol Source Type: research

Revolutionizing Atopic Dermatitis, 5 April 2020.
Authors: PMID: 32242919 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 2, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

15th Medical Dermatology Meeting, Royal College of Physicians, London, 9 January 2020.
Authors: PMID: 32236944 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 31, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

BJD Reviewers January 2019 - December 2019.
Authors: PMID: 32236946 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 31, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

It's the worry that got him in the end: the importance in treating melanoma holistically and dealing with fear of recurrence.
PMID: 32236948 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 31, 2020 Category: Dermatology Authors: Thompson AR, Cockayne S Tags: Br J Dermatol Source Type: research

Skin cancer screening: it's a matter of time.
PMID: 32237075 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 31, 2020 Category: Dermatology Authors: Ferris LK Tags: Br J Dermatol Source Type: research

Gene-environment interactions and melanoma risk.
PMID: 32239507 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 31, 2020 Category: Dermatology Authors: Cust AE Tags: Br J Dermatol Source Type: research

Paraneoplastic neutrophilic leukemoid reaction in a melanoma patient: association between tumour volume and leukocytosis.
We report the case of a PNLR that occurred during a metastatic melanoma and for which we retrospectively studied the relationship between PMNs count, tumour mass, serum LDH and G-CSF levels. PMID: 32232827 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 29, 2020 Category: Dermatology Authors: Fredeau L, Bohelay G, Shourick J, Piver D, Guyot A, -H Schlageter M, Caux F, Maubec E Tags: Br J Dermatol Source Type: research