Frequency of 'regular' skin checks by dermatologists for melanoma survivors.
PMID: 31774148 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 27, 2019 Category: Dermatology Authors: Robinson JK Tags: Br J Dermatol Source Type: research

Neoadjuvant Immunotherapy with combined Ipilimumab and Nivolumab in Melanoma Patients with Primary or In-transit Disease.
Abstract The introduction of new therapeutic agents has revolutionized the treatment of metastatic melanoma. The approval of adjuvant anti-PD-1 monotherapy with nivolumab or pembrolizumab and dabrafenib plus trametinib has recently set a new landmark in the treatment of stage III melanoma. Now, clinical trials have shown that immune checkpoint blockade can be performed in a neoadjuvant setting, an approach established as a standard therapeutic approach for other tumour entities such as breast cancer. Recent studies suggest that a pathologic response achieved by neoadjuvant immunotherapy is associated with a long-t...
Source: The British Journal of Dermatology - November 26, 2019 Category: Dermatology Authors: Weber J, Glutsch V, Geissinger E, Haug L, Lock JF, Schneider F, Kneitz H, Goebeler M, Schilling B, Gesierich A Tags: Br J Dermatol Source Type: research

Immune checkpoint blockade: an urgent call for biomarkers to help guide treatment.
PMID: 31773721 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 26, 2019 Category: Dermatology Authors: Karakousis G Tags: Br J Dermatol Source Type: research

Rosacea treatment: a patient-centric approach.
PMID: 31773725 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 26, 2019 Category: Dermatology Authors: Elewski B Tags: Br J Dermatol Source Type: research

Dupilumab in adolescent atopic dermatitis: interpreting the data.
PMID: 31769016 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 25, 2019 Category: Dermatology Authors: Sibbald C Tags: Br J Dermatol Source Type: research

Persistence of treatment with conventional systemic agents for patients with psoriasis: a real-world analysis of 73,168 new-users from the French National Health Insurance database (SNDS).
Abstract Psoriasis is a chronic inflammatory skin disorder which can have a significant effect on the quality of life1 . There is currently no cure for psoriasis, but there are numerous treatments which are useful in controlling symptoms; thus, long-term treatment is usually required. Conventionals are among the oldest interventions given to clear psoriasis. Treatment persistence, a relevant indicator of therapeutic success2 , has received particular attention in the field of psoriasis, with most studies focusing on the persistence of biologics3,4 . PMID: 31758801 [PubMed - as supplied by publisher] (Source: ...
Source: The British Journal of Dermatology - November 23, 2019 Category: Dermatology Authors: Bergqvist C, Mezzarobba M, Weil A, Sbidian E Tags: Br J Dermatol Source Type: research

High Capillary Diameter In Psoriatic Plaques Of The Lower Legs.
ali G Abstract We read with interest the study conducted by Hjuler et al. on 146 psoriatic patients' partial responders (PASI=1-5) to biologics, in which the most common recalcitrant sites were the anterior and posterior part of the lower legs, elbows, and scalp [1]. Other reports indicate the distal lower extremities as notoriously treatment resistant [2]. A recent non-invasive diagnostic technique in psoriasis is represented by videodermatoscopy (VD) which is able to reveal a typical vascular pattern consisting of dilated and convoluted capillaries ("bushy pattern") homogeneously distributed on the les...
Source: The British Journal of Dermatology - November 23, 2019 Category: Dermatology Authors: Lacarrubba F, Verzì AE, Musumeci ML, Micali G Tags: Br J Dermatol Source Type: research

A non-epidermolytic keratinocytic epidermal naevus associated with a post-zygotic mutation in the gene encoding the epidermal growth factor receptor.
Abstract Non-epidermolytic keratinocytic epidermal nevi (KEN) are benign congenital skin lesions exhibiting verrucous acanthosis and hyperkeratosis characterized by a linear distribution along the lines of Blaschko. Non-epidermolytic KEN arise as a result of prenatal postzygotic mutations in components of either the rat sarcoma (RAS)/mitogen-activated protein kinase (MAPK) pathway or phosphoinositide-3 kinase (PI3K)/AKT pathway. PMID: 31745974 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 20, 2019 Category: Dermatology Authors: Umegaki-Arao N, Ono N, Tanaka R, Sasaki T, Fujita H, Shiohama A, Aoki S, Amagai M, Kubo A Tags: Br J Dermatol Source Type: research

Immune checkpoint inhibitor-induced vitiligo in advanced melanoma could be related to increased levels of CCL19.
Abstract Immune checkpoint inhibitors (ICIs) are in wide use for the treatment of various cancers. Although anti-PD-1 antibody (Ab)-based combined therapy might be effective for the treatment of advanced melanoma, the associated risk of immune-related adverse events (irAEs) is an important consideration 1, 2 . In contrast to these severe AEs, vitiligo is reported to correlate with improved prognosis among advanced melanoma patients treated with ICI therapy 3 . Indeed, vitiligo correlated with statistically significant differences in overall survival among patients with metastatic melanoma 3 . The present study inv...
Source: The British Journal of Dermatology - November 20, 2019 Category: Dermatology Authors: Fujimura T, Tanita K, Sato Y, Lyu C, Kambayashi Y, Fujisawa Y, Uchi H, Yamamoto Y, Otsuka A, Yoshino K, Matsushita S, Funakoshi T, Fukushima S, Hata H, Hashimoto A, Aiba S Tags: Br J Dermatol Source Type: research

Treatment of hereditary hypotrichosis simplex of the scalp with topical gentamicin.
CONCLUSIONS: Our findings indicate that topical gentamicin should be considered as a potential therapeutic modality in HSS. PMID: 31746457 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 20, 2019 Category: Dermatology Authors: Peled A, Samuelov L, Sarig O, Bochner R, Malki L, Pavlovsky M, Pichinuk E, Weil M, Sprecher E Tags: Br J Dermatol Source Type: research

The diagnostic accuracy of dermoscopy and reflectance confocal microscopy for amelanotic/hypomelanotic melanoma: a systematic review and meta-analysis.
CONCLUSION: Our study demonstrates that both dermoscopy and RCM offer good diagnostic accuracy with high specificity and moderate sensitivity in the diagnosis of AHM. RCM is more accurate than dermoscopy in diagnosing AHM but the comparison needed to be confirmed. PMID: 31747045 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 20, 2019 Category: Dermatology Authors: Lan J, Wen J, Cao S, Yin T, Jiang B, Lou Y, Zhu J, An X, Suo H, Li D, Zhang Y, Tao J Tags: Br J Dermatol Source Type: research

Does polygenic risk influence associations between sun exposure and melanoma?: a prospective cohort analysis.
Abstract Melanoma develops as the result of complex interactions between sun exposure and genetic factors. Data on these interactions from prospective studies are scant however. We aimed to quantify the association between ambient and personal ultraviolet (UV) exposure and incident melanoma in a large population-based prospective study of men and women residing in a high ambient UV setting, and to examine potential gene-environment interactions. Among participants with genetic data (n=15,373), 420 (2.7%) developed cutaneous melanoma (173 invasive, 247 in situ) during a median follow-up time of 4.4 years. Country o...
Source: The British Journal of Dermatology - November 20, 2019 Category: Dermatology Authors: Olsen CM, Pandeya N, Law MH, MacGregor S, Iles MM, Thompson BS, Green AC, Neale RE, Whiteman DC, QSkin Study Tags: Br J Dermatol Source Type: research

Podiatrists gaining a foothold.
PMID: 31749140 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 20, 2019 Category: Dermatology Authors: Moss C Tags: Br J Dermatol Source Type: research

Assessment of the healthcare costs for pemphigus and bullous pemphigoid patients in an academic center in Germany.
dwig RJ Abstract The autoimmune skin blistering diseases pemphigus (vulgaris and foliaceus) and bullous pemphigoid (BP) pose a high burden on affected patients. With current treatment options, induction of remission is achieved in most patients. However, prolonged immunosuppression is required to maintain remission, and treatment-related morbidity and mortality further adds to the patients' burden1,2 . Hence, development of novel therapeutic strategies that are effective and safe is highly warranted. Recently, insights into pemphigus and BP pathogenesis identified new therapeutic targets and drugs3 . PMID: 31...
Source: The British Journal of Dermatology - November 20, 2019 Category: Dermatology Authors: Ständer S, Färber B, Radeke S, Schmidt E, Zillikens D, Ludwig RJ Tags: Br J Dermatol Source Type: research

Clinical and histopathological characterization of paradoxical head and neck erythema in atopic dermatitis patients treated with dupilumab: a case series.
We report on 7 AD patients presenting with a paradoxical head-neck erythema which appeared 10 to 39 weeks after start of dupilumab treatment. Patients presented with a relatively sharp demarcated, patchy erythema in the head and neck area that showed no or less scaling compared to their usual eczema. Only 1 patient experienced symptoms of itch and burning, although this was notably different from his pre-existent facial AD. Except for a notable "red face", eczema on other body parts had greatly improved in 6 out of 7 patients with a mean NRS treatment satisfaction of 9/10 at time of biopsy. Treatment of the eryth...
Source: The British Journal of Dermatology - November 20, 2019 Category: Dermatology Authors: de Wijs LEM, Nguyen NT, Kunkeler ACM, Nijsten T, Damman J, Hijnen DJ Tags: Br J Dermatol Source Type: research

A hands-off approach may be more successful in treating chronic hand eczema.
PMID: 31749174 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 20, 2019 Category: Dermatology Authors: Strowd LC, Feldman SR Tags: Br J Dermatol Source Type: research

Good practice in dermatological patient-reported outcome measure development: an example from localized scleroderma.
PMID: 31742657 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 19, 2019 Category: Dermatology Authors: Nelson PA Tags: Br J Dermatol Source Type: research

Hailey-Hailey Disease with Acantholysis of the Oral and Esophagogastric Mucosa.
Abstract a 65 year old woman with history of Hailey-Hailey disease (HHD) was followed for recurrent painful blistering eruptions in the axillary, inframammary and inguinal folds (Fig. 1a). Her mother and son also carried a diagnosis of HHD. PMID: 31742658 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 19, 2019 Category: Dermatology Authors: Fresco A, Jacob J, Raciti P, Ciocon D, Amin B, Mann R Tags: Br J Dermatol Source Type: research

Differences between acral and nonacral melanoma genomes.
PMID: 31742660 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 19, 2019 Category: Dermatology Authors: Johansson P Tags: Br J Dermatol Source Type: research

Shaping specialist treatment of Stevens-Johnson syndrome/toxic epidermal necrolysis.
PMID: 31742662 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 19, 2019 Category: Dermatology Authors: Walsh S, Creamer D Tags: Br J Dermatol Source Type: research

Image Gallery: Pemphigus vulgaris mimicking acrodermatitis continua of Hallopeau.
PMID: 31742663 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 19, 2019 Category: Dermatology Authors: Chen Q, Du J, Jin J, Zhang J Tags: Br J Dermatol Source Type: research

Development and preliminary validation of the Adolescent Psoriasis Quality of Life instrument (APso-QOL): a disease-specific measure of quality of life in adolescents with psoriasis.
CONCLUSIONS: The preliminary form of the instrument APso-QOL shows promising psychometric properties. It can be used in daily clinical practice and research to support a patient-centered approach and inform treatment planning. PMID: 31743420 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 19, 2019 Category: Dermatology Authors: Randa H, Khoury LR, Grønborg TK, Lomholt JJ, Skov L, Zachariae R Tags: Br J Dermatol Source Type: research

Recurrent headache and facial ecchymosis: a case of dermatitis artefacta? Reply from authors.
Abstract We really appreciate your comment about our rare clinical case report. The first time we visited this patient we thought about the possibility of a cutaneous factitious disorder. Consequently, we conducted a comprehensive interview with the patient and her family who repeatedly denied mental problems and the use of topical products on the skin during the headache episodes. Moreover, we requested a psychiatry evaluation that was strictly normal. PMID: 31736050 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 17, 2019 Category: Dermatology Authors: Garcia-Souto F Tags: Br J Dermatol Source Type: research

Associations of eczema phenotypes with emotional and behavioural problems from birth until school age. The Generation R Study.
CONCLUSION: Eczema phenotypes are very modestly associated with more somatic symptoms and attention problems at school age. Early transient eczema is associated with more aggressive behaviour symptoms. Directional effects seem from early life eczema to later life internalizing and externalizing problems rather than reversely. PMID: 31730242 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 15, 2019 Category: Dermatology Authors: Hu C, Nijsten T, Pasmans SGMA, de Jongste JC, Jansen PW, Duijts L Tags: Br J Dermatol Source Type: research

Minimally important change: approach to interpretation of patient-reported outcomes.
Abstract Skin and subcutaneous diseases were the fourth leading cause of nonfatal burden in 2013 according the Global Burden of Disease study.1 Skin diseases may cause symptoms, disfigurement and psychological morbidity that cannot be fully expressed as the area and severity of skin lesions. Patient-reported outcomes (PROs), widely used as the end points in clinical trials, capture the effects of interventions from the patient's perspective. PMID: 31730243 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 15, 2019 Category: Dermatology Authors: Shen MX, Chen X Tags: Br J Dermatol Source Type: research

T cell polarization differs in various stages of discoid lupus erythematosus skin.
Abstract The clinical presentation and pathology of discoid lupus erythematosus (DLE) varies by stage. Erythematous scaly papules and plaques characterize the early lesions. They progress to dyspigmented patches and plaques with central scarring and atrophy. Under histology, early lesions demonstrate a perivascular and perifollicular inflammatory infiltrate, liquefactive degeneration and keratinocyte apoptosis. Increased collagen deposition within the dermis and reduced inflammatory infiltrate is seen in later stages [1]. PMID: 31721152 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 13, 2019 Category: Dermatology Authors: Coias J, Marzuka A, Hosler GA, Chong BF Tags: Br J Dermatol Source Type: research

The Utility of Subcutaneous Methotrexate for Chronic Plaque Psoriasis in a Real-World Setting.
Abstract The advent of biologic agents that target cytokines central to the psoriatic disease cascade have revolutionised the treatment of moderate to severe psoriasis. Methotrexate (MTX) remains the recommended first-line conventional systemic treatment for moderate to severe psoriasis.1 This is due to its well established efficacy, safety profile and low cost1 . Across published data, MTX demonstrates a PASI 75 of approximately 40% at weeks 12-162 , with a median drug survival of 1.8 years.3 The cost of oral MTX is less than 1%, and subcutaneous (SC) MTX less than 10% of that of the cheapest biologic agent in th...
Source: The British Journal of Dermatology - November 12, 2019 Category: Dermatology Authors: Hollywood A, O'Keeffe C, Boggs J, Feighery C, Collins S Tags: Br J Dermatol Source Type: research

Dermatology Life Quality Index: does improving the instrument make it better?
PMID: 31709517 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 11, 2019 Category: Dermatology Authors: Bashyam AM, Feldman SR Tags: Br J Dermatol Source Type: research

Digital UVB phototherapy in vitiligo: proof of concept.
Abstract Phototherapy with UVB light is considered to be a cornerstone in the treatment of vitiligo.1-3 However, performing phototherapy in a non-targeted way results in tanning of vitiligo-adjacent and -free skin. A therapy-enhanced pigment difference between healthy and diseased skin (though in the case of phototherapy most often only transient) represents an important reason for insufficient therapy satisfaction with regard to cosmetic outcome in particular for facial lesions. PMID: 31705524 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 9, 2019 Category: Dermatology Authors: Graier T, Hofer A, Wolf P Tags: Br J Dermatol Source Type: research

Guselkumab is superior to fumaric acid esters in patients with moderate-to-severe plaque psoriasis who are na ïve to systemic treatment: Results from a randomised, active comparator-controlled phase 3b trial (POLARIS).
Guselkumab is superior to fumaric acid esters in patients with moderate-to-severe plaque psoriasis who are naïve to systemic treatment: Results from a randomised, active comparator-controlled phase 3b trial (POLARIS). Br J Dermatol. 2019 Nov 09;: Authors: Thaҫi D, Pinter A, Sebastian M, Termeer C, Sticherling M, Gerdes S, Wegner S, Krampe S, Bartz H, Rausch C, Mensch A, Eyerich K Abstract BACKGROUND: Guselkumab, a fully human interleukin-23 antibody, is approved for systemic treatment of patients with moderate-to-severe plaque psoriasis. OBJECTIVES: To compare efficacy and safety of guselku...
Source: The British Journal of Dermatology - November 9, 2019 Category: Dermatology Authors: Thaҫi D, Pinter A, Sebastian M, Termeer C, Sticherling M, Gerdes S, Wegner S, Krampe S, Bartz H, Rausch C, Mensch A, Eyerich K Tags: Br J Dermatol Source Type: research

Under-recognised effects on our canine and feline companions with 5-fluorouracil use.
Abstract 5-fluorouracil (5-FU) is a topical treatment routinely used to treat actinic keratosis and superficial basal cell carcinomas in humans. As clinicians, we often consent the known adverse effects1 on humans such as erythema, irritation, photosensitivity and prolonged inflammation. PMID: 31705648 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 9, 2019 Category: Dermatology Authors: Ho B, Bates N, Edwards N, Robinson N, Ellison J Tags: Br J Dermatol Source Type: research

Defining drug-free remission of skin disease in patients with plaque psoriasis.
Abstract Systemic therapies currently approved for psoriasis lead to significant improvement and even complete clearance of skin disease. Although treatment discontuniuation is often associated with disease relapse, a proportion of patients may maintain a durable and lengthy response after treatment withdrawal.1-4 While these observations suggest the possibility of long-term remission, the definition of 'remission' of skin disease in psoriasis is not standard, and building consensus would facilitate clinical and scientific inquiry into this important concept. PMID: 31705649 [PubMed - as supplied by publisher]...
Source: The British Journal of Dermatology - November 9, 2019 Category: Dermatology Authors: Armstrong AW, Blauvelt A, Crowley JJ, Gordon KB, Krueger GG, Krueger JG, Sobell JM, Strober BE, Srivastava B, Menter A Tags: Br J Dermatol Source Type: research

Recurrent headache and facial ecchymosis: a case of dermatitis artefacta?
Abstract I read the case recently published as an image gallery in the Journal about a 22 year-old woman, who developed transient and relapsing facial ecchymosis during attacks of trigeminal cephalalgias [1]. As laboratory and imaging were unremarkable, the authors suggested that the cutaneous symptoms "may result from blood extravasation to skin due to trigemino-vascular activation and autonomic vascular dysfunction". Upon examination of the clinical photographic features, the patient displays a striking dark-red, well-delimitated, sometimes linear streak of the right cheek, extending to the neck up to ...
Source: The British Journal of Dermatology - November 8, 2019 Category: Dermatology Authors: Kluger N Tags: Br J Dermatol Source Type: research

Outcome measures in dermatomyositis: quality of life and the patient perspective.
PMID: 31705532 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 8, 2019 Category: Dermatology Authors: Nicholson LT, Haemel A Tags: Br J Dermatol Source Type: research

Unravelling the microbiome in psoriasis.
PMID: 31705536 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 8, 2019 Category: Dermatology Authors: Tobin AM Tags: Br J Dermatol Source Type: research

The Hidradenitis Suppurativa Quality of Life (HiSQOL) score: Development and validation of a measure for clinical trials.
DISCUSSION: The HiSQOL is a reliable and valid instrument to measure HS-specific HRQOL for clinical trials. PMID: 31705538 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 8, 2019 Category: Dermatology Authors: Kirby JS, Thorlacius L, Villumsen B, Ingram JR, Garg A, Christensen KB, Butt M, Esmann S, Tan J, Jemec GBE Tags: Br J Dermatol Source Type: research

Cross-country generalizability of quality-of-life scores in atopic dermatitis.
PMID: 31705541 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 8, 2019 Category: Dermatology Authors: Rencz F Tags: Br J Dermatol Source Type: research

The impact of Hidradenitis suppurativa on work productivity and activity impairment.
Abstract Hidradenitis suppurativa (HS) is an inflammatory skin condition affecting skin fold regions. HS is associated with a marked reduction in quality-of-life (QoL), financial burden,1 and high incidence of comorbid mental illness.2 This disease begins in early adulthood, a time of psychiatric vulnerability and immense professional growth. This is a critical time in planning careers and establishing social contacts that overtime may change an individual's life course.3 However, there is limited research on HS's impact on employment and work productivity. PMID: 31707731 [PubMed - as supplied by publisher] (...
Source: The British Journal of Dermatology - November 8, 2019 Category: Dermatology Authors: Sandhu VK, Shah M, Piguet V, Alavi A Tags: Br J Dermatol Source Type: research

Young people's perceptions of acne and acne treatments: secondary analysis of qualitative interview data.
CONCLUSION: People with acne need support to manage their condition effectively, particularly a better understanding of different topicals, how to use them and how to avoid side effects. Unrealistic expectations about the onset of action of treatments appears to be a common cause of frustration and non-adherence. Directing people towards accessible evidence-based information is crucial. PMID: 31701523 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 7, 2019 Category: Dermatology Authors: Ip A, Muller I, Geraghty AWA, McNiven A, Little P, Santer M Tags: Br J Dermatol Source Type: research

Ivermectin use in children below 15 kg: potential benefits for onchocerciasis and scabies elimination programs.
Abstract We read with interest the paper by M Levy et al about the treatment of scabies with ivermectin in infants and children under 15kg of body weight1 . The authors describe the results of a multicentre observational study conducted in France between 2012-15, among 170 children with body weight 4 to 14.5kg. Children were treated with a mean dose of ivermectin of 223µg/kg, and 89% of them had received two doses. Adverse events were observed in only seven participants (4%), none of which were severe. Therefore, they concluded that a therapeutic trial in infants and young children needs to be performed. ...
Source: The British Journal of Dermatology - November 6, 2019 Category: Dermatology Authors: Colebunders R, Wafula ST, Hotterbeekx A, Siewe-Fodjo JN Tags: Br J Dermatol Source Type: research

Is there an optimal irradiation dose for PDT: 37 Jcm-2 or 75 Jcm-2 ?
Abstract Topical photodynamic therapy (PDT) is widely used for the treatment of Bowen's disease (BD) and superficial basal cell carcinoma (BCC). The process involves oxygen-dependent light activation of the tissue-localised photosensitiser, protoporphyrin IX, three hours after pro-drug application to the lesion. Current approved and licensed regimens involve application of either methylaminolevulinate (MAL, Metvix, Galderma, Switzerland) or 5-aminolaevulinic acid in nanocolloid emulsion (ALA, Ameluz gel, Biofrontera, Germany) and subsequent light activation using narrow spectrum (630-635 nm) red light (typically l...
Source: The British Journal of Dermatology - November 2, 2019 Category: Dermatology Authors: Todd BK, Lesar A, O'Mahoney P, Eadie E, Ibbotson SH Tags: Br J Dermatol Source Type: research

A qualitative study on the patient's narrative in the progression of Chronic Venous Disease into a first Venous Leg Ulcer: a series of events.
CONCLUSION: A reduction in Mobility as a result of Comorbidity and Work & Lifestyle occurred before the VLU developed. Patients did not recognise symptoms of CVD and did not acknowledge the chronicity of CVD. Health Care Professionals should be aware of reductions in mobility and the knowledge deficit in patients with CVD. PMID: 31677155 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 1, 2019 Category: Dermatology Authors: Meulendijks AM, Welbie M, Tjin EPM, Schoonhoven L, Neumann HAM Tags: Br J Dermatol Source Type: research

The role of bacterial skin infections in atopic dermatitis: expert statement and review from the International Eczema Council Skin Infection Group.
Abstract Patients with atopic dermatitis (AD) have an increased risk of bacterial skin infections that cause significant morbidity and, if untreated, may become systemic. Staphylococcus aureus (S. aureus) colonizes the skin of most AD subjects and is the most common organism to cause infections. Overt bacterial infection is easily recognised by the appearance of weeping lesions, honey-coloured crusts, and pustules. However, the wide variability in clinical presentation of bacterial infection in AD and the inherent features of AD - cutaneous erythema and warmth, oozing associated with oedema, and regional lymphaden...
Source: The British Journal of Dermatology - November 1, 2019 Category: Dermatology Authors: Alexander H, Paller AS, Traidl-Hoffmann C, Beck LA, De Benedetto A, Dhar S, Girolomoni G, Irvine AD, Spuls P, Su J, Thyssen JP, Vestergaard C, Werfel T, Wollenberg A, Deleuran M, Flohr C Tags: Br J Dermatol Source Type: research

Naevus count and MC1R R alleles contribute to melanoma risk.
This study, from Australia, aimed to find out if having both those risk factors increased melanoma risk more than the two risk levels simply added together. 611 people with melanoma and 656 who had never had melanoma donated a DNA sample, and researchers recorded the number of large moles, their skin and eye colour, and hair colour at age 21. The authors found that people with red hair and 20+ large moles were 10 times more likely to have melanoma than people with 0-4 moles and dark brown hair. Looking specifically at the types of the MC1R gene that people carried, people with 20+ moles and MC1R R/R genotype were 25 times ...
Source: The British Journal of Dermatology - November 1, 2019 Category: Dermatology Authors: Duffy DL, Lee KJ, Jagirdar K, Pflugfelder A, Stark MS, McMeniman EK, Soyer HP, Sturm RA Tags: Br J Dermatol Source Type: research

Why is the high risk of skin cancer in organ transplant recipients declining?
PMID: 31674666 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 1, 2019 Category: Dermatology Authors: Gjersvik P Tags: Br J Dermatol Source Type: research

Vitamin D: one more argument for broad-spectrum ultraviolet A  + ultraviolet B sunscreen protection.
Vitamin D: one more argument for broad-spectrum ultraviolet A + ultraviolet B sunscreen protection. Br J Dermatol. 2019 Nov;181(5):881-882 Authors: Wolf P PMID: 31674668 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 1, 2019 Category: Dermatology Authors: Wolf P Tags: Br J Dermatol Source Type: research

Are we facing a change in the treatment of chronic pruritus?
PMID: 31674670 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 1, 2019 Category: Dermatology Authors: Metz M Tags: Br J Dermatol Source Type: research

Obituary: Dr Harvey Baker, 1930-2019.
PMID: 31674671 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 1, 2019 Category: Dermatology Authors: Clement M Tags: Br J Dermatol Source Type: research

Linear IgA/IgG bullous dermatosis with autoantibodies directing the native and processed forms of BP180.
Abstract Linear IgA bullous dermatosis (LABD) is an autoimmune blistering skin disorder associated with IgA-class autoantibodies directing autoantigens in the basement membrane zone (BMZ). LABD autoantibodies mainly target either the 120-kDa (LAD1) and 97-kDa (LABD97) processed extracellular polypeptides of BP180 (also known as collagen XVII) or collagen VII, and these LABD types are respectively known as lamina-densa type- and sublamina-densa type-LABD.1,2 In LABD, the linear deposition of IgG-class autoantibodies can be observed at the dermal-epidermal junction (DEJ), and such cases have been recently reported a...
Source: The British Journal of Dermatology - November 1, 2019 Category: Dermatology Authors: Inamura E, Nishie W, Yamaguchi Y, Fujimura Y, Ujiie H, Natsuga K, Shimizu H Tags: Br J Dermatol Source Type: research

Clinical significance of BRAF/NRAS concurrent mutations in a clinic-based metastatic melanoma cohort.
Abstract Innovative therapeutic strategies in metastatic melanoma depend on molecular features and the combination of BRAF and MEK inhibitors (BRAFi+MEKi) which has recently shown an improved clinical efficacy in BRAFV600MUT metastatic melanoma patients, is now the standard of care. BRAF and NRAS activating mutations lead to the MAPK pathway deregulation1 and may coexist despite their earlier description as mutually exclusive2 . This event is probably related to the existence of several mutually-exclusive subclones corresponding to a mixture of singly-mutated melanoma cells or may have arisen as shown by in vitro ...
Source: The British Journal of Dermatology - November 1, 2019 Category: Dermatology Authors: Del Regno L, Louveau B, Battistella M, Sadoux A, Baroudjian B, Delyon J, Serror K, Allayous C, Lebbe C, Mourah S, Jouenne F Tags: Br J Dermatol Source Type: research