Clinical response to immune checkpoint inhibition in patients with advanced skin cancers receiving concurrent ruxolitinib therapy for hematologic malignancy.
Abstract Patients who are being treated with Janus-Kinase (JAK) inhibitors for hematologic conditions have a higher risk of developing non-melanoma skin cancers (NMSC) with an aggressive course1,2 . This has been attributed to relative immune-suppression that can accompany the use of JAK inhibitors, from their effects on T-cell signaling pathways3 . Acquired inactivating mutations in JAK 1 and JAK 2 genes have been reported to lead to a loss of programmed death ligand-1 (PD-L1) expression and a lack of response to interferon-γ (IFN-γ) in melanoma, contributing to acquired resistance to anti-programmed ...
Source: The British Journal of Dermatology - October 15, 2020 Category: Dermatology Authors: Haddad N, Delyon J, Trabelsi Messai S, Herms F, Leccia MT, Lebbe C, Whitney J, Bhatia S, Basset-Seguin N Tags: Br J Dermatol Source Type: research

Lost in translation: True Clinical Impact of RCM Overlooked in "Biopsy outperforms Reflectance Confocal Microscopy in Diagnosing and Subtyping Basal Cell Carcinoma: Results and Experiences from a Randomized Controlled Multicentre Trial": reply from authors.
Lost in translation: True Clinical Impact of RCM Overlooked in "Biopsy outperforms Reflectance Confocal Microscopy in Diagnosing and Subtyping Basal Cell Carcinoma: Results and Experiences from a Randomized Controlled Multicentre Trial": reply from authors. Br J Dermatol. 2020 Oct 15;: Authors: Woliner-van der Weg W, Peppelman M, van Erp PEJ, Lubeek SFK Abstract First, we would like to thank M. Gill and colleagues for their interest shown in our study.1,2 We agree on the importance to determine the place of reflectance confocal microscopy (RCM) as a diagnostic tool in real-world clinical pra...
Source: The British Journal of Dermatology - October 15, 2020 Category: Dermatology Authors: Woliner-van der Weg W, Peppelman M, van Erp PEJ, Lubeek SFK Tags: Br J Dermatol Source Type: research

Patient age and risk of recurrence of primary melanoma at high risk of spread.
Abstract Melanoma is more aggressive with poorer outcomes in older than younger patients. Older age has been associated with greater tumour thickness, higher rates of ulceration, and high mitotic rates,1,2 but it is not clear whether poorer outcomes in the elderly are solely due to these tumour-specific features or to additional effects of age-related decline in in immune surveillance, greater comorbidity, and age-related behaviours such as delayed diagnosis. PMID: 33053218 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 14, 2020 Category: Dermatology Authors: Ghiasvand R, Khosrotehrani K, Hughes MCB, von Schuckmann LA, Beesley VL, Malt M, Smithers BM, Green AC Tags: Br J Dermatol Source Type: research

Never the twain shall meet? Bridging the divide between patient perspectives and health professionals and systems.
PMID: 33048345 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 13, 2020 Category: Dermatology Authors: Capozza K Tags: Br J Dermatol Source Type: research

Aetiology and pathogenesis of hidradenitis suppurativa.
Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory disorder. Patients develop inflamed nodules and abscesses and, at later stages of disease, epithelialized tunnels and scars in skinfolds of axillary, inguinal, gluteal and perianal areas. Quality of life is affected due to severe pain, purulent secretion, restricted mobility and systemic involvement. Genetics and lifestyle factors including smoking and obesity contribute to the development of HS. These factors lead to microbiome alteration, subclinical inflammation around the terminal hair follicles, and infundibular hyperkeratosis, resulting in plug...
Source: The British Journal of Dermatology - October 13, 2020 Category: Dermatology Authors: Wolk K, Join-Lambert O, Sabat R Tags: Br J Dermatol Source Type: research

A qualitative exploration of the experiences of adolescents with alopecia areata and their messages for healthcare professionals.
Abstract Alopecia areata (AA) is an autoimmune disorder characterised by non-scarring hair loss, which affects nearly 2% of the population with 60% experiencing their first episode of hair loss before the age of 20 1 2 . The pattern of hair loss is highly variable and unpredictable, from well-defined patches to total hair loss. AA can have a transformative effect on an individual, and has significant psychological consequences for many, with high levels of anxiety and depression well-documented3 4 . These effects can be particularly profound in adolescence5 , with AA an additional challenge affecting appearance du...
Source: The British Journal of Dermatology - October 11, 2020 Category: Dermatology Authors: de Vere Hunt I, McNiven A, McPherson T Tags: Br J Dermatol Source Type: research

Complete skin clearance and beyond.
PMID: 33029797 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 8, 2020 Category: Dermatology Authors: Schmitt-Egenolf M Tags: Br J Dermatol Source Type: research

The global burden of atopic dermatitis: lessons from the GBD Study - 1990 to 2017.
Abstract The Global Burden of Disease (GBD) Study provides an annually updated resource to study disease-related morbidity and mortality worldwide. Here we present the burden estimates for atopic dermatitis (AD), including data from inception of the GBD project in 1990 until 2017. Atopic dermatitis (AD) ranks 15th among all non-fatal diseases and has the highest disease burden among skin diseases as measured by disability-adjusted life years (DALYs). Overall, the global DALY rate for AD in 1990 was 120.83 (65.37-201.04) and remained similar in 2017 at 123.31 (66.79-205.17) in 2017. The 3 countries with the highest...
Source: The British Journal of Dermatology - October 1, 2020 Category: Dermatology Authors: Laughter MR, Maymone MBC, Mashayekhi S, Arents BWM, Karimkhani C, Langan SM, Dellavalle RP, Flohr C Tags: Br J Dermatol Source Type: research

Investigating  Human Eyelash Hair Follicle Growth In Situ and Ex Vivo: A pilot study.
Investigating Human Eyelash Hair Follicle Growth In Situ and Ex Vivo: A pilot study. Br J Dermatol. 2020 Oct 02;: Authors: Platt CI, Laybourne J, Cannon P, Paus R Abstract Eyelashes (ELs) play a crucial role in protecting the eye from airborne particles and are intimately connected with human beauty1 . Clinically, trichomegaly, hypotrichosis and trichiasis are the result of aberrant EL growth, which can compromise EL function, result in secondary morbidity and, in severe cases, result in blindness. ...
Source: The British Journal of Dermatology - October 1, 2020 Category: Dermatology Authors: Platt CI, Laybourne J, Cannon P, Paus R Tags: Br J Dermatol Source Type: research

Randomised controlled trial of topical corticosteroid and home-based narrowband UVB for active and limited vitiligo - results of the HI-Light Vitiligo trial.
CONCLUSION: Combination treatment with home-based hand-held NB-UVB plus TCS is likely to be superior to TCS alone for treatment of localised vitiligo. Combination treatment was relatively safe and well tolerated but was only successful in around a quarter of participants. PMID: 33006767 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 1, 2020 Category: Dermatology Authors: Thomas KS, Batchelor JM, Akram P, Chalmers JR, Haines RH, Meakin GD, Duley L, Ravenscroft JC, Rogers A, Sach TH, Santer M, Tan W, White J, Whitton ME, Williams HC, Cheung ST, Hamad H, Wright A, Ingram JR, Levell NJ, Goulding JMR, Makrygeorgou A, Bewley A, Tags: Br J Dermatol Source Type: research

Anti-drug antibodies to TNF inhibitors in hidradenitis suppurativa: a systematic review.
Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory condition which affects apocrine gland-rich skin.1 It primarily develops in intertriginous areas, including the axilla, groin, perianal, and perineal regions and presents with recurrent, painful nodules, abscesses, draining tunnels, and scarring.1 Despite the continuing research and development of biologics for HS, biologics can lead to the formation of anti-drug antibodies (ADAs) that inactivate the therapeutic effects of the treatment, leading to a decreased drug level and resulting in a suboptimal response.2. PMID: 33006769 [PubMed - as suppl...
Source: The British Journal of Dermatology - October 1, 2020 Category: Dermatology Authors: Lu JD, Milakovic M, Piguet V, Alavi A Tags: Br J Dermatol Source Type: research

Long-term effectiveness of dupilumab up to 52 weeks in atopic dermatitis in 253 adult patients.
onara M, Detoraki A, Ferrucci SM Abstract Dupilumab, an inhibitor of interleukin (IL)-4/13 activity, is a biological agent approved for the treatment of moderate-to-severe atopic dermatitis (AD)1 . Our aim was to assess the long-term effectiveness and safety of dupilumab in a clinical real-life setting. PMID: 32998177 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 29, 2020 Category: Dermatology Authors: Nettis E, Fabbrocini G, Ortoncelli M, Pellacani G, Argenziano G, Di Leo E, Patruno C, Stingeni L, Foti C, Rongioletti F, Macchia L, Tavecchio S, Napolitano M, Ribero S, Bonzano L, Calabrese G, Di Bona D, Nisticò SP, Hansel K, Romita P, Piras V, Carbonara Tags: Br J Dermatol Source Type: research

Efficacy of in-class IL-23 inhibitor switching: Risankizumab following Guselkumab failure in moderate-to-severe psoriasis treatment.
Abstract The development of drugs that target the Th17 axis has had a profound effect on the treatment and management of psoriasis. IL-23 inhibitors in particular, including guselkumab and risankizumab have been shown to be highly effective and have a favorable safety profile.1 Though recent studies have shown that in-class biologic switching can be effective in the treatment of psoriasis, no investigation has assessed the efficacy of an in-class IL-23 inhibitor switch.2,3. PMID: 32998185 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 29, 2020 Category: Dermatology Authors: Reddy R, Pannu S, Fiumara K, Kahn J, Rosmarin D Tags: Br J Dermatol Source Type: research

Effectiveness of clindamycin and rifampicin combination-therapy in hidradenitis suppurativa: a six-months prospective study.
en SF Abstract treatment of Hidradenitis Suppurativa (HS) with systemic antibiotics are first line therapy according to European S1 guidelines [1]. Yet, despite being the most investigated antibiotic regimen in HS, the evidence-based literature on clindamycin and rifampicin in HS is limited and primarily based on retrospective studies [2-5]. Additionally, despite the lack of evidence on the long-term risks, the suggested treatment duration is 10 weeks due to the risk of side effects and concerns regarding antibiotic resistance [6]. PMID: 33000461 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 29, 2020 Category: Dermatology Authors: Yao Y, Jørgensen AR, Ring HC, Thomsen SF Tags: Br J Dermatol Source Type: research

SARS-CoV-2 Has Not Been Detected Directly by Electron Microscopy in the Endothelium of Chilblain Lesions.
Abstract We are concerned that yet another erroneous report of the electron microscopical observation of coronavirus in tissue has been published. The paper by Colmenero et al. presents a study of skin biopsies from paediatric patients presenting with chilblains during the COVID-19 pandemic.1 Seven cases were examined by histopathological and immunohistochemical techniques, and one of these was additionally studied by transmission electron microscopy. PMID: 33000462 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 29, 2020 Category: Dermatology Authors: Brealey JK, Miller SE Tags: Br J Dermatol Source Type: research

SARS-CoV-2 Has Not Been Detected Directly by Electron Microscopy in the Endothelium of Chilblain Lesions: reply from authors.
, Torrelo A Abstract We fully agree that the interpretation of electron microscopy findings can be challenging, even for experts. Differences between viral pathogens and normal subcellular organelles may be subtle, and some cellular components can masquerade as viruses. The size and shape of the particle shown in our paper fit with other descriptions of SARS-CoV-2, but there may be a bias in interpretation. PMID: 33000464 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 29, 2020 Category: Dermatology Authors: Colmenero I, Santonja C, Alonso-Riaño M, Andina D, Rodríguez Peralto JL, Requena L, Torrelo A Tags: Br J Dermatol Source Type: research

Tralokinumab for moderate-to-severe atopic dermatitis: results from two  52-week, randomized, double-blind, multicentre, placebo-controlled phase III trials (ECZTRA 1 and ECZTRA 2).
Tralokinumab for moderate-to-severe atopic dermatitis: results from two 52-week, randomized, double-blind, multicentre, placebo-controlled phase III trials (ECZTRA 1 and ECZTRA 2). Br J Dermatol. 2020 Sep 30;: Authors: Wollenberg A, Blauvelt A, Guttman-Yassky E, Worm M, Lynde C, Lacour JP, Spelman L, Katoh N, Saeki H, Poulin Y, Lesiak A, Kircik L, Cho SH, Herranz P, Cork MJ, Peris K, Steffensen LA, Bang B, Kuznetsova A, Jensen TN, Østerdal ML, Simpson EL Abstract BACKGROUND: Tralokinumab, a fully human monoclonal antibody, specifically neutralizes interleukin-13, a key cytokine driving per...
Source: The British Journal of Dermatology - September 29, 2020 Category: Dermatology Authors: Wollenberg A, Blauvelt A, Guttman-Yassky E, Worm M, Lynde C, Lacour JP, Spelman L, Katoh N, Saeki H, Poulin Y, Lesiak A, Kircik L, Cho SH, Herranz P, Cork MJ, Peris K, Steffensen LA, Bang B, Kuznetsova A, Jensen TN, Østerdal ML, Simpson EL Tags: Br J Dermatol Source Type: research

GGCX mutations in a patient with PXE/CL-like overlapping phenotype.
Abstract Pseudoxanthoma elasticum (PXE) is a multisystem disorder characterized by ectopic mineralization of connective tissues with primary manifestations in the skin, eyes, and cardiovascular system. The classic forms of PXE are caused by mutations in the ABCC6 gene encoding the ABCC6 protein expressed primarily in the liver. Cutis laxa (CL) manifests with loose and sagging skin with loss of recoil. In 2009 we investigated a 19-year-old patient with overlapping cutaneous features of PXE and CL, together with alpha thalassemia. Genetic analysis failed to identify pathogenic mutations in ABCC6. More recently we de...
Source: The British Journal of Dermatology - September 29, 2020 Category: Dermatology Authors: Li D, Ryu E, Saeidian AH, Youssefian L, Oliphant E, Terry SF, Tong PL, Uitto J, Haass NK, Li Q Tags: Br J Dermatol Source Type: research

Tralokinumab plus topical corticosteroids for the treatment of moderate-to-severe atopic dermatitis: results from the double-blind, randomized, multicentre, placebo-controlled phase III ECZTRA 3 trial.
Abstract BACKGROUND: Tralokinumab is a fully human monoclonal antibody that specifically neutralizes interleukin-13, a key driver of atopic dermatitis (AD). OBJECTIVES: To evaluate the efficacy and safety of tralokinumab in combination with TCS in patients with moderate-to-severe AD who were candidates for systemic therapy. METHODS: This was a double-blind, placebo plus optional TCS-controlled phase III trial. Patients were randomized 2 : 1 to subcutaneous tralokinumab 300 mg or placebo every 2 weeks (Q2W) with TCS as needed over 16 weeks. Patients who achieved an Investigator's Global Assessment (I...
Source: The British Journal of Dermatology - September 29, 2020 Category: Dermatology Authors: Silverberg JI, Toth D, Bieber T, Alexis AF, Elewski BE, Pink AE, Hijnen D, Jensen TN, Bang B, Olsen CK, Kurbasic A, Weidinger S Tags: Br J Dermatol Source Type: research

Response to 'No evidence of SARS-CoV-2 infection by polymerase chain reaction or serology in children with pseudo-chilblain'. Reply from the authors.
ve; M Abstract Dear Editor, Recalcati et al. conclude that chilblain-like lesions (CLLs) are part of the spectrum of COVID-19 based on reports of SARS-CoV-2 in endothelial cells of skin biopsies assessed by immunohistochemistry and electron microscopy (EM).1 Nevertheless, the conclusion does not seem to be adequately supported by the data. Recalcati et al. expand their previously reported case series to include 32 patients with CLLs. In 21 of 32 cases, no nasopharyngeal swab (NPS) was tested for SARS-CoV-2. Two of 11 patients subjected to molecular testing were positive for SARS-CoV-2, but no serological test was ...
Source: The British Journal of Dermatology - September 24, 2020 Category: Dermatology Authors: Caselli D, Chironna M, Loconsole D, Aricò M Tags: Br J Dermatol Source Type: research

Applications and Future Directions for Optical Coherence Tomography in Dermatology.
Abstract Optical coherence tomography (OCT) is a non-invasive optical imaging method that can generate high-resolution en-face and cross-sectional images of the skin in vivo to a maximum depth of 2mm. Whilst OCT holds considerable potential for non-invasive diagnosis and disease monitoring, it is poorly understood by many dermatologists. Here, we aim to equip the practicing dermatologist with an understanding of the principles of skin OCT and the potential clinical indications. We begin with an introduction to the technology and discuss the different modalities of OCT including angiographic (dynamic) OCT, which ca...
Source: The British Journal of Dermatology - September 23, 2020 Category: Dermatology Authors: Wan B, Ganier C, Du-Harpur X, Harun N, Watt FM, Patalay R, Lynch MD Tags: Br J Dermatol Source Type: research

Dupilumab provides favourable long-term safety and efficacy in children aged ≥ 6 to < 12 years with uncontrolled, severe atopic dermatitis: results from an open-label phase IIa study and subsequent phase III open-label extension study.
Dupilumab provides favourable long-term safety and efficacy in children aged ≥ 6 to
Source: The British Journal of Dermatology - September 23, 2020 Category: Dermatology Authors: Cork MJ, Thaçi D, Eichenfield LF, Arkwright PD, Sun X, Chen Z, Akinlade B, Boklage S, Guillemin I, Kosloski MP, Kamal MA, O'Malley JT, Patel N, Graham NMH, Bansal A Tags: Br J Dermatol Source Type: research

Outcomes for Pressure Ulcer Trials (OUTPUTs) project: first key step on a long journey.
PMID: 32969490 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 23, 2020 Category: Dermatology Authors: Eleftheriadou V Tags: Br J Dermatol Source Type: research

Prevalence of mucocutaneous manifestations, oral and palmoplantar findings in 666 patients with COVID-19 in a field hospital in Spain.
Oliver P, Montero Vega MD, Herranz Pinto P Abstract Coronavirus disease 2019 (Covid-2019) has been associated with several cutaneous manifestations(1-3). A temporary field hospital was implemented during the pandemic peak in Madrid, Spain, to attend COVID-19 patients with mild to moderate pneumonia. PMID: 32969503 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 23, 2020 Category: Dermatology Authors: Nuno-Gonzalez A, Martin-Carrillo P, Magaletsky K, Martin Rios MD, Herranz Mañas C, Artigas Almazan J, García Casasola G, Perez Castro E, Gallego Arenas A, Mayor Ibarguren A, Feito Rodríguez M, Lozano Masdemont B, Beato M, Ruiz Bravo E, Oliver P, Monter Tags: Br J Dermatol Source Type: research

Hidradenitis Suppurativa Area and Severity Index Revised (HASI-R): psychometric property assessment.
The objectives of the study were to assess inter-rater and intra-rater reliability of the HASI-R and its components, as well as its construct and known groups validity. Existing lesion count-based clinician-reported measures of HS and their components were also assessed. Raters were also asked their preferences regarding the various HS severity assessment tools. RESULTS: The HASI-R had moderate inter-rater reliability (ICC = 0.60). This was better than all other HS physical sign outcome measures evaluated, which had poor inter-rater reliability (ICC
Source: The British Journal of Dermatology - September 22, 2020 Category: Dermatology Authors: Goldfarb N, Lowes MA, Butt M, King T, Alavi A, Kirby JS Tags: Br J Dermatol Source Type: research

Interventions for chronic palmoplantar pustulosis: abridged Cochrane systematic review and GRADE assessments.
CONCLUSIONS: Evidence is lacking for or against major chronic PPP treatments. Risk of bias and imprecision limit our confidence in the results. PMID: 32961599 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 21, 2020 Category: Dermatology Authors: Obeid G, Do G, Kirby L, Hughes C, Sbidian E, Le Cleach L Tags: Br J Dermatol Source Type: research

The science and rationale of arriving at the correct drug & dosimetry of griseofulvin, fluconazole, terbinafine, and itraconazole in superficial dermatophyte infections: an important step before a pragmatic trial.
The science and rationale of arriving at the correct drug & dosimetry of griseofulvin, fluconazole, terbinafine, and itraconazole in superficial dermatophyte infections: an important step before a pragmatic trial. Br J Dermatol. 2020 Sep 21;: Authors: Sardana K, Mathachan SR Abstract While India faces the issue of recalcitrant dermatophytosis1 , we would like to focus on the scientific rationale of drug dosimetry based on background microbiological data & existential serum/skin level data (Figure 1) that should predate a clinical trial2 . The first step is based on the minimum inhibitory conce...
Source: The British Journal of Dermatology - September 20, 2020 Category: Dermatology Authors: Sardana K, Mathachan SR Tags: Br J Dermatol Source Type: research

The global burden of chronic urticaria for the patient and society.
L, Weller K, Maurer M Abstract Chronic urticaria (CU) affects about 1% of the world population of all ages, mostly young/middle-aged females, usually lasts for several years (>1 year in 25-75% of patients), and often takes>1 year before effective management is implemented. It presents as chronic spontaneous urticaria (CSU), chronic inducible urticaria (CIndU) or both in the same person. More than 25% of cases are resistant to H1-antihistamines, even at higher doses, and 3rd and 4th line therapy (omalizumab and ciclosporin) control the disease only in two thirds of H1 -antihistamine resistant patients. Here, ...
Source: The British Journal of Dermatology - September 20, 2020 Category: Dermatology Authors: Gonçalo M, Gimenéz-Arnau A, Al-Ahmad M, Ben-Shoshan M, Bernstein JA, Ensina LF, Fomina D, Galvàn CA, Godse K, Grattan C, Hide M, Katelaris CH, Khoshkhui M, Kocatürk E, Kulthanan K, Medina I, Nasr I, Peter J, Staubach P, Wang L, Weller K, Maurer M Tags: Br J Dermatol Source Type: research

Long-term efficacy of certolizumab pegol for psoriasis.
PMID: 32951203 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 19, 2020 Category: Dermatology Authors: Johnson MC, Heron CE, Feldman SR Tags: Br J Dermatol Source Type: research

Early life regulation of inflammation in atopic dermatitis by microRNA.
PMID: 32951210 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 19, 2020 Category: Dermatology Authors: Polak ME Tags: Br J Dermatol Source Type: research

Efficacy and safety of ixekizumab after switching from fumaric acid esters or methotrexate in patients with moderate-to-severe plaque psoriasis na ïve to systemic treatment.
Efficacy and safety of ixekizumab after switching from fumaric acid esters or methotrexate in patients with moderate-to-severe plaque psoriasis naïve to systemic treatment. Br J Dermatol. 2020 Sep 17;: Authors: Leutz A, Pinter A, Thaçi D, Augustin M, Schuster C, Fotiou K, Hundemer HP, Saure D, Mrowietz U, Reich K Abstract Psoriasis is a chronic inflammatory skin disorder, which, in cases of moderate-to-severe disease, requires long-term systemic therapy.1 For patients with an inadequate response or intolerance to a specific systemic therapy, switching psoriasis treatments is a common pract...
Source: The British Journal of Dermatology - September 16, 2020 Category: Dermatology Authors: Leutz A, Pinter A, Thaçi D, Augustin M, Schuster C, Fotiou K, Hundemer HP, Saure D, Mrowietz U, Reich K Tags: Br J Dermatol Source Type: research

Efficacy of topical ropivacaine in children and young adults with hereditary Epidermolysis Bullosa.
Abstract Epidermolysis bullosa (EB) is a heterogeneous group of rare inherited skin disorders that cause fragile, blistering skin.There are 4 major types: EB simplex (EBS), junctional EB (JEB) dystrophic EB (DEB) and Kindler EB1 . The chronic wounds cause severe pain and a major alteration of quality of life. PMID: 32939751 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 15, 2020 Category: Dermatology Authors: Moreno Artero E, Schinkel N, Chaumon S, Corset I, Rabeony T, Elie C, Bellon N, Bodemer C, Greco C Tags: Br J Dermatol Source Type: research

A novel non-drug SFRP1 antagonist inhibits catagen development in human hair follicles ex vivo.
aus R Abstract Wnt signalling is one of the most fundamental molecular pathways for modulating the human hair cycle and is essential for maintaining hair growth1 . We recently identified that the Wnt antagonist, secreted frizzled related protein 1 (SFRP1), prematurely induces catagen in microdissected human scalp hair follicles (HFs) ex vivo1 . SFRP1 is inhibited by the potent hypertrichosis inducing immunosuppressant, cyclosporine A (CsA)2 , and the specific SFRP1 antagonist, WAY-316606, both of which prevent spontaneous catagen development1 . PMID: 32939777 [PubMed - as supplied by publisher] (Source: The B...
Source: The British Journal of Dermatology - September 15, 2020 Category: Dermatology Authors: Bertolini M, Chéret J, Pinto D, Hawkshaw N, Ponce L, Erdmann H, Jimenez F, Funk W, Paus R Tags: Br J Dermatol Source Type: research

Development of a Pathogenesis-Based Therapy for Peeling Skin Syndrome Type 1.
CONCLUSION: The study presents the first preclinical in vitro experiments for a future specific protein replacement therapy for patients suffering from PSS1. PMID: 32926582 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 13, 2020 Category: Dermatology Authors: Valentin F, Wiegmann H, Tarinski T, Nikolenko H, Traupe H, Liebau E, Dathe M, Oji V Tags: Br J Dermatol Source Type: research

Evaluation of Malignancy Risk in Scleroderma by Antibody Profile.
Abstract An increased risk of malignancy in systemic sclerosis (SSc) has been reported.1 Moreover, a close temporal relationship between onset of SSc and malignancy has been reported in patients with anti-RNA polymerase III antibody.2 We conducted this study to add to the available data on types and rates of malignancy and to evaluate if our SSc population showed an association between cancer and SSc onset and whether this risk was different in different SSc-specific autoantibody groups. PMID: 32920853 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 12, 2020 Category: Dermatology Authors: Lertphanichkul C, Smith GP Tags: Br J Dermatol Source Type: research

An economic evaluation of the randomised controlled trial of topical corticosteroid and home-based narrowband UVB for active and limited vitiligo (The HI-Light Trial).
gboli M, Stainforth J, Ferguson A, Laguda B, Wahie S, Ellis R, Azad J, Rajasekaran A, Eleftheriadou V, Montgomery AA, UK Dermatology Clinical Trials Network’s HI-LIGHT Vitiligo Trial Team Abstract BACKGROUND: Economic evidence for vitiligo treatments is absent. OBJECTIVE: To determine the cost-effectiveness of (a) hand-held narrowband-UVB (NB-UVB) and (b) combination of topical corticosteroid (TCS) and NB-UVB compared to TCS for localised vitiligo. METHODS: Cost-effectiveness analysis alongside a pragmatic, 3-arm, placebo-controlled RCT with 9 months' treatment. 517 Adults and children (aged ≥5 ...
Source: The British Journal of Dermatology - September 11, 2020 Category: Dermatology Authors: Sach TH, Thomas KS, Batchelor JM, Akram P, Chalmers JR, Haines RH, Meakin GD, Duley L, Ravenscroft JC, Rogers A, Santer M, Tan W, White J, Whitton ME, Williams HC, Cheung ST, Hamad H, Wright A, Ingram JR, Levell N, Goulding JMR, Makrygeorgou A, Bewley A, Tags: Br J Dermatol Source Type: research

A Call to Standardise the BCC:SCC Ratio.
Abstract Basal cell carcinoma (BCC) followed by squamous cell carcinoma (SCC) are the two commonest cancers in white populations worldwide.1 While sharing some features, they are distinct clinically and pathologically and thus the ratio of BCC to SCC incidence rates serves as a useful composite that enables immediate comparisons of trends within and between populations. There is a widely held belief that the BCC:SCC ratio sits relatively constantly at around 4:1 in the general population, though this belief has little apparent basis. PMID: 32920840 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 11, 2020 Category: Dermatology Authors: Jiyad Z, Marquart L, Green AC Tags: Br J Dermatol Source Type: research

What determines the treatment persistence in paediatric psoriasis?
PMID: 32909247 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 9, 2020 Category: Dermatology Authors: Salman A Tags: Br J Dermatol Source Type: research

Genotypic and Phenotypic Analysis of 34 Cases of Inherited Junctional Epidermolysis Bullosa caused by COL17A1 Mutations.
We report 34 JEB patients with COL17A1 genetic mutations diagnosed in our Center between 1993 and 2019. Medical and biological records were collected with a standardized questionnaire. PMID: 32911566 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 9, 2020 Category: Dermatology Authors: Charlesworth A, Hérissé AL, Bellon N, Leclerc-Mercier S, Bourrat E, Hadj-Rabia S, Bodemer C, Lacour JP, Chiaverini C Tags: Br J Dermatol Source Type: research

Identifying key components and therapeutic targets of the immune system in hidradenitis suppurativa with an emphasis on neutrophils.
Abstract Hidradenitis suppurativa (HS) is a chronic, inflammatory, recurrent, and debilitating skin disease of the hair follicle unit that typically develops after puberty. The disorder is characterized by comedones, painful inflammatory nodules, abscesses, dermal tunnels, and scarring, with a predilection for intertriginous areas of the body (axillae, inguinal, and anogenital regions). Recruitment of neutrophils to HS lesion sites may play an essential role in the development of the painful inflammatory nodules and abscesses that characterize the disease. This is a review of the major mediators involved in the re...
Source: The British Journal of Dermatology - September 6, 2020 Category: Dermatology Authors: Narla S, Azzam M, Townsend S, Vellaichamy G, Marzano AV, Alavi A, Lowes MA, Hamzavi IH Tags: Br J Dermatol Source Type: research

Comorbid acne inversa and Dowling-Degos disease due to a single NCSTN mutation - is there enough evidence?
k J Abstract In their recent publication in the Br J Dermatol, Garcovich et al. suggested that a nonsense mutation in the NCSTN (Nicastrin) gene, R583*, would underlie comorbid familial acne inversa (FAI; synonym: familial hidradenitis suppurativa) and Dowling-Degos disease (DDD) in a 54-year old patient [1]. PMID: 32894577 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 6, 2020 Category: Dermatology Authors: Hermasch MA, Schön MP, Frank J Tags: Br J Dermatol Source Type: research

Patterns of cutaneous immune-related adverse events in adults and children with advanced sarcoma: A retrospective cohort study.
Abstract Immune checkpoint inhibitors (ICIs) have improved survival for multiple malignancies in adults and children.1,2 However, their benefits are tempered by a range of serious immune-related adverse events (irAEs). 1,2 Among these, cutaneous irAEs (cirAEs) represent one of the most common subtypes, impacting approximately one-third of adult patients receiving ICIs.1,3 The patterns and significance of cirAEs in children remain unclear, largely because these reactions have not been evaluated in detail. PMID: 32894776 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 6, 2020 Category: Dermatology Authors: Thompson LL, Chang MS, McCormack L, Polyakov N, Yoon J, Song H, Huang JT, Chen ST Tags: Br J Dermatol Source Type: research

Comorbid acne inversa and Dowling-Degos disease due to a single NCSTN mutation - is there enough evidence?: reply from the authors.
Abstract we thank Hermasch et al. for their comments on our paper describing the novel NCSTN R583* mutation associated to familial acne inversa (FAI) in an Italian family, where the proband was also clinically diagnosed with Dowling-Degos disease (DDD). In our report, we raised the attention on this particular patient subset with comorbid FAI-DDD, emphasizing the connection between autoinflammatory-keratinization disorders and genetic reticulated pigmentary disorders. Based on our findings, we think that there ais enough evidence to claim that R583* NCSTN mutation is associated with DDD and FAI. PMID: 3289592...
Source: The British Journal of Dermatology - September 6, 2020 Category: Dermatology Authors: Garcovich S, Tricarico PM, Meddour CN, Giovanardi G, Peris K, Crovella S, Boniotto M Tags: Br J Dermatol Source Type: research

Ruptured hair follicles of the scalp mimicking malignant melanoma.
PMID: 32892340 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 5, 2020 Category: Dermatology Authors: Elsarafy S, Tobiss H, Veitch D, Bhuchar M, Khan M, Patel A Tags: Br J Dermatol Source Type: research

Light in the dark: distinct effects of dimethyl fumarate on different T-cell subsets in psoriasis treatment.
PMID: 32892342 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 5, 2020 Category: Dermatology Authors: Mostafa A, Murata T, Kabashima K Tags: Br J Dermatol Source Type: research

Infantile bullous pemphigoid following serogroup B meningococcal vaccination.
Linares-Barrios M PMID: 32892343 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 5, 2020 Category: Dermatology Authors: Navarro-Navarro I, Jiménez-Gallo D, Valenzuela-Ubiña S, Domínguez-Gomez M, Linares-Barrios M Tags: Br J Dermatol Source Type: research

There is still a place for tumour-targeted therapies in Merkel cell carcinoma in the era of immune checkpoint inhibitors.
PMID: 32892361 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 5, 2020 Category: Dermatology Authors: Samimi M, Becker J Tags: Br J Dermatol Source Type: research

Tocilizumab and other targeted therapies for severe cutaneous immune-related adverse events.
PMID: 32892364 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 5, 2020 Category: Dermatology Authors: Thompson LL, Chen ST Tags: Br J Dermatol Source Type: research

Characteristics and Impacts of Itch in Children with Inflammatory Skin Disorders.
Abstract BACKGROUND: Itch is a cardinal feature of pediatric disorders and can impair quality of life. However, few studies have addressed symptoms and impacts of itch in pediatric patients. OBJECTIVES: We focused on understanding the child's experience of itch and impact of itch specifically on affected children, including by comparison with the adult experience. METHODS: Semi-structured interviews (9 parents/15 children with itch) explored concerns related to pediatric itch experiences and effects. Themes were compared with those of previous adult interviews. Literature was reviewed to identify need fo...
Source: The British Journal of Dermatology - September 5, 2020 Category: Dermatology Authors: Fang MM, Nowinski CJ, Lai J, Shaunfield S, Silverberg JI, Rangel SM, Cella D, Paller AS Tags: Br J Dermatol Source Type: research

The Epidemiology of Malignant Melanoma, Squamous Cell Carcinoma, and Basal Cell Carcinoma in the United Kingdom from 2004-2014: A Population-Based Cohort Analysis using the Clinical Practice Research Datalink.
Abstract Skin cancers, including malignant melanoma and keratinocyte skin cancers, are the most common malignancy in the United Kingdom (UK), and global incidence is increasing rapidly1 . While malignant melanoma (MM) accounts for most skin cancer deaths, keratinocyte skin cancers, squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), comprise up to 95% of skin cancer cases in the UK2,3 . Studies on trends in MM incidence and survival have been conducted using Scottish, Northern Irish, and English and Welsh data4 . PMID: 32893341 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 5, 2020 Category: Dermatology Authors: Mirza FN, Yumeen S, Walter FM Tags: Br J Dermatol Source Type: research