Women with moderate-severe psoriasis in Spain (Biobadaderm registry) show over a 50% reduction in age-adjusted fertility rate when compared with the general population.
This article is protected by copyright. All rights reserved. PMID: 31127858 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 25, 2019 Category: Dermatology Authors: Gonzalez-Cantero A, Carretero G, Rivera R, Ferrándiz C, Daudén E, de la Cueva P, Gómez-García FJ, Belinchón I, Herrera-Ceballos E, Ruiz-Genao D, Ferrán M, Alsina M, Sánchez-Carazo JL, Baniandrés O, Sahuquillo-Torralba A, Rodriguez L, Vilar J, Garc Tags: Br J Dermatol Source Type: research

Real-world effectiveness and safety of dupilumab for the treatment of atopic dermatitis in Japanese patients: A single-centre retrospective study.
This article is protected by copyright. All rights reserved. PMID: 31127860 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 25, 2019 Category: Dermatology Authors: Uchida H, Kamata M, Mizukawa I, Watanabe A, Agematsu A, Nagata M, Fukaya S, Hayashi K, Fukuyasu A, Tanaka T, Ishikawa T, Ohnishi T, Tada Y Tags: Br J Dermatol Source Type: research

A treatment protocol for botulinum toxin injections in the treatment of pachyonychia congenita-associated keratoderma.
Abstract BACKGROUND: Severely debilitating plantar keratoderma pain is the most distressing clinical feature of pachyonychia congenita (PC). Several earlier publications reported therapeutic success with botulinum toxin (Btx) plantar injections. OBJECTIVES: To describe our 4-year experience during which we administered a total of 30 plantar Btx injections to five PC patients following an optimized protocol. METHODS: Five patients with PC (age 21-54 years) who were treated at our medical center from 4/2015 to 6/2018 were included in the study. After an ultrasound-guided nerve block performed by an anesthe...
Source: The British Journal of Dermatology - May 25, 2019 Category: Dermatology Authors: Koren A, Sprecher E, Reider E, Artzi O Tags: Br J Dermatol Source Type: research

The association of scalp psoriasis with overall psoriasis severity and koebnerization in children: cross-sectional findings from the Dutch ChildCAPTURE registry.
This article is protected by copyright. All rights reserved. PMID: 31127952 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 25, 2019 Category: Dermatology Authors: Bronckers IMGJ, Maatkamp M, Kievit W, van de Kerkhof PCM, de Jong EMGJ, Seyger MMB Tags: Br J Dermatol Source Type: research

Acute exanthemas: a prospective study of 98 adult patients with emphasis of cytokinic and metagenomic investigation.
CONCLUSION: Routine investigations revealed HHV6 as the most frequent. Histology did not discriminate MPEs. In idiopathic MPE, the alarmin IL-33 could suggest an environmental factor as a trigger. Results of metagenomic analysis in skin samples question the interest of routine PCR and viral serologies. This article is protected by copyright. All rights reserved. PMID: 31127953 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 25, 2019 Category: Dermatology Authors: Deschamps O, Ortonne N, Hüe S, Rodriguez C, Deschodt C, Hirsch G, Colin A, Grégoire L, Delfau-Larue MH, Chosidow O, Wolkenstein P, Ingen-Housz-Oro S Tags: Br J Dermatol Source Type: research

Quality of life remains poor for patients with pemphigus vulgaris despite targeted therapies.
This article is protected by copyright. All rights reserved. PMID: 31127954 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 25, 2019 Category: Dermatology Authors: Schultz B, Latour E, Fett N Tags: Br J Dermatol Source Type: research

Bullous pemphigoid autoantibody-mediated complement fixation is abolished by the low-molecular-weight heparin tinzaparin sodium.
This article is protected by copyright. All rights reserved. PMID: 31124130 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 24, 2019 Category: Dermatology Authors: Gutjahr A, Heck F, Emtenani S, Hammers AK, Hundt JE, Muck P, Siegel DL, Schmidt E, Stanley JR, Zillikens D, Hammers CM Tags: Br J Dermatol Source Type: research

Monotherapy for toenail onychomycosis: a systematic review and network meta-analysis.
CONCLUSIONS: Our review suggests that oral and topical treatments for toenail onychomycosis are safe and effective in producing mycological cure. This article is protected by copyright. All rights reserved. PMID: 31120134 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 23, 2019 Category: Dermatology Authors: Gupta AK, Foley KA, Mays RR, Shear NH, Piguet V Tags: Br J Dermatol Source Type: research

Non-invasive objective skin measurement methods for rosacea assessment: a systematic review.
CONCLUSIONS: This systematic review describes the spectrum of non-invasive imaging and biophysical methods in rosacea assessment, giving multifaceted information about structure and properties of rosacea skin, especially useful for research purposes. Larger studies with good methodological quality are needed to create validated protocols for further implementation into research. This article is protected by copyright. All rights reserved. PMID: 31120136 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 23, 2019 Category: Dermatology Authors: Logger JGM, de Vries FMC, van Erp PEJ, de Jong EMGJ, Peppelman M, Driessen RJB Tags: Br J Dermatol Source Type: research

Erdheim-Chester Disease: Expanding the spectrum of cutaneous manifestations.
CONCLUSION: The most common presentation in ECD is periorbital XLL. Other presentations include non-facial cutaneous xanthomas, panniculitis-like lesions, and granuloma annulare-like lesions. Associated symptoms at presentation include bone/extremity pain and weight loss. This article is protected by copyright. All rights reserved. PMID: 31120137 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 23, 2019 Category: Dermatology Authors: Kobic A, Shah KK, Schmitt AR, Goyal G, Go RS, Guo R, Rech KL, Sartori-Valinotti JC Tags: Br J Dermatol Source Type: research

Longitudinal study of congenital melanocytic naevi reveals that final colour is determined by normal skin colour, and is unaltered by superficial removal techniques.
Abstract BACKGROUND: Spontaneous lightening of Congenital Melanocytic Naevi (CMN) has not been studied systematically. Final colour is considered an important outcome after superficial removal techniques such as curettage, dermabrasion or laser ablation, and is often compared to colour at birth. OBJECTIVE: To quantify the natural history of CMN lightening over time, and explore phenotypic and genotypic predictors of colour change. METHODS: A longitudinal cohort study was undertaken of 110 patients with CMN, mean follow up 5.3 years. Accurate colour-space measurements were taken from professional serial p...
Source: The British Journal of Dermatology - May 23, 2019 Category: Dermatology Authors: Polubothu S, Kinsler VA Tags: Br J Dermatol Source Type: research

Non-blanchable erythema for predicting pressure ulcer development: a systematic review with an individual participant data meta-analysis.
CONCLUSIONS: The first prognostic factor review with individual-level data analysis in pressure ulcers suggests people with non-blanchable erythema are more likely to develop new pressure ulcers of Stage 2 or above within 28 days than people without non-blanchable erythema. It is important to identify non-blanchable erythema in practice and intervene appropriately to prevent pressure ulceration. This article is protected by copyright. All rights reserved. PMID: 31120145 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 23, 2019 Category: Dermatology Authors: Shi C, Bonnett LJ, Dumville JC, Cullum N Tags: Br J Dermatol Source Type: research

Happle-Tinschert, Curry-Jones and segmental basal cell naevus syndromes: overlapping disorders caused by somatic mutations in hedgehog-signalling genes - the mosaic Hedgehog spectrum.
This article is protected by copyright. All rights reserved. PMID: 31120550 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 23, 2019 Category: Dermatology Authors: Lovgren ML, Zhou Y, Hrčková G, Dallos T, Colmenero I, Twigg SRF, Moss C Tags: Br J Dermatol Source Type: research

Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi.
In conclusion, in this large cohort study we document the prevalence of the two major causal genotypes, clarify the relationship between genotype and size of CMN, confirm and expand knowledge of genotype-phenotype differences with nodularity, and demonstrate no difference in neurological disease in childhood between the three genotypic groups. Genotyping of CMN should however be undertaken in suspected melanoma for guidance of treatment. This article is protected by copyright. All rights reserved. PMID: 31111470 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 21, 2019 Category: Dermatology Authors: Polubothu S, McGuire N, Al-Olabi L, Baird W, Bulstrode N, Chalker J, Josifova D, Lomas D, O'Hara J, Ong J, Rampling D, Stadnik P, Thomas A, Wedgeworth E, Sebire NJ, Kinsler VA Tags: Br J Dermatol Source Type: research

The role of misclassification of exposure in the association between aspirin and non-steroidal anti-inflammatory drug use and keratinocyte cancers.
This article is protected by copyright. All rights reserved. PMID: 31112288 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 21, 2019 Category: Dermatology Authors: Abtahi S, Oshagbemi OA, van Veelen A, van Geel RM Tags: Br J Dermatol Source Type: research

Detection of cell-free circulating BRAFV 600E by droplet digital PCR in melanoma and non-melanoma patients under dermatological surveillance.
CONCLUSIONS: The study suggests that naevus related factors do not influence the detection of cfBRAFV 600E in non-melanoma individuals, and support the clinical diagnostic value of plasma cfBRAFV 600E quantification in melanoma patients. This article is protected by copyright. All rights reserved. PMID: 31102256 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 18, 2019 Category: Dermatology Authors: Calbet-Llopart N, Potrony M, Tell-Martí G, Carrera C, Barreiro A, Aguilera P, Podlipnik S, Puig S, Malvehy J, Puig-Butillé JA Tags: Br J Dermatol Source Type: research

Incidence and prevalence of alopecia areata according to subtype: A nationwide, population-based study in South Korea (2006-2015).
This article is protected by copyright. All rights reserved. PMID: 31102412 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 18, 2019 Category: Dermatology Authors: Lee JH, Kim HJ, Han KD, Han JH, Bang CH, Park YM, Lee JY, Lee SJ, Park YG, Lee YB Tags: Br J Dermatol Source Type: research

Immunotherapeutic Strategies for Cutaneous Squamous Cell Carcinoma Prevention in Xeroderma Pigmentosum.
This article is protected by copyright. All rights reserved. PMID: 31102460 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 18, 2019 Category: Dermatology Authors: Ameri AH, Mooradian MJ, Emerick KS, Park JC, Wirth LJ, Asgari MM, Tsao H, Lawrence D, Sullivan RJ, Demehri S Tags: Br J Dermatol Source Type: research

Deep dermatophytosis caused by Microsporum ferrugineum in a patient with CARD9 mutations.
This article is protected by copyright. All rights reserved. PMID: 31102464 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 18, 2019 Category: Dermatology Authors: Zhang Y, Mijiti J, Huang C, Song Y, Wan Z, Li R, Kang X, Wang X Tags: Br J Dermatol Source Type: research

Depression in Hidradenitis Suppurativa.
This article is protected by copyright. All rights reserved. PMID: 31099413 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 17, 2019 Category: Dermatology Authors: Senthilnathan A, Kolli SS, Cardwell LA, Richardson IM, Feldman SR, Pichardo RO Tags: Br J Dermatol Source Type: research

A qualitative analysis of psychological distress in Hidradenitis Suppurativa.
CONCLUSIONS: This study has highlighted that feelings of shame and physical pain are associated with psychological distress in HS. This article is protected by copyright. All rights reserved. PMID: 31099891 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 17, 2019 Category: Dermatology Authors: Keary E, Hevey D, Tobin AM Tags: Br J Dermatol Source Type: research

Secukinumab dosing optimization in patients with moderate to severe plaque psoriasis: Results from the randomised, open-label OPTIMISE study.
Abstract BACKGROUND: Secukinumab is a fully human monoclonal antibody that selectively binds to and neutralises interleukin-17A. OBJECTIVE: To assess the efficacy and safety of different maintenance-dosing regimens of secukinumab 300 mg based on PASI response at Week 24 in patients with moderate to severe plaque psoriasis. METHODS: OPTIMISE was a randomised, open-label, rater-blinded Phase 3b study. Subjects (n=1,647) received secukinumab 300 mg at baseline, Weeks 1, 2, 3, and 4, and every 4 weeks (q4w) to Week 24. At Week 24, PASI 90 responders (n=1306) were randomised to secukinumab 300 mg q4w (n=644) ...
Source: The British Journal of Dermatology - May 17, 2019 Category: Dermatology Authors: Reich K, Puig L, Szepietowski JC, Paul C, Lacour JP, Tsianakas A, Sieder C, Rissler M, Pournara E, Orsenigo R Tags: Br J Dermatol Source Type: research

The role of misclassification of exposure in the association between aspirin and non-steroidal anti-inflammatory drug use and keratinocyte cancers: Reply from authors.
This article is protected by copyright. All rights reserved. PMID: 31102262 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 17, 2019 Category: Dermatology Authors: Pandeya N, Olsen CM, Whiteman DC Tags: Br J Dermatol Source Type: research

Responsiveness of the EQ-5D-3L, DLQI, and DLQI-R for Patients With Psoriasis in the United States.
This article is protected by copyright. All rights reserved. PMID: 31102266 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 17, 2019 Category: Dermatology Authors: Barbieri J, Gelfand JM Tags: Br J Dermatol Source Type: research

Utilization Patterns and Performance of Commercial Myositis Autoantibody Panels in Routine Clinical Practice.
This article is protected by copyright. All rights reserved. PMID: 31102270 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 17, 2019 Category: Dermatology Authors: Gandiga PC, Zhang J, Sangani S, Thomas P, Werth VP, George MD Tags: Br J Dermatol Source Type: research

Significant Limitations of a Systematic Review and Meta-Analysis of Interventions to Promote Skin Self-Examination.
This article is protected by copyright. All rights reserved. PMID: 31093960 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 15, 2019 Category: Dermatology Authors: Coups EJ Tags: Br J Dermatol Source Type: research

Significant Limitations of a Systematic Review and Meta-Analysis of Interventions to Promote Skin Self-Examination: Reply from Authors.
This article is protected by copyright. All rights reserved. PMID: 31093961 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 15, 2019 Category: Dermatology Authors: Authors. Tags: Br J Dermatol Source Type: research

Clinical Practice Guidelines for Epidermolysis Bullosa Laboratory Diagnosis.
This article is protected by copyright. All rights reserved. PMID: 31090061 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 15, 2019 Category: Dermatology Authors: Has C, Liu L, Bolling M, Charlesworth AV, El Hachem M, Escámez MJ, Fuentes I, Büchel S, Hiremagalore R, Pohla-Gubo G, van den Akker P, Wertheim-Tysarowska K, Zambruno G Tags: Br J Dermatol Source Type: research

Keratinocyte footprint assay discriminates anti-laminin-332 pemphigoid from all other forms of pemphigoid diseases.
CONCLUSIONS: The keratinocyte footprint assay is a fast and specific assay to confirm or rule out the presence of anti-laminin-332 autoantibodies. This article is protected by copyright. All rights reserved. PMID: 31090065 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 15, 2019 Category: Dermatology Authors: Giurdanella F, Nijenhuis AM, Diercks GFH, Jonkman MF, Pas HH Tags: Br J Dermatol Source Type: research

TH 22 cells from Han Chinese patients with atopic dermatitis exhibit high expression of ICOS.
CONCLUSION: Our findings demonstrate that ICOS/ICOSL expression and effects are linked to TH 22 skewing and the pathogenesis of Han Chinese AD, which suggests ICOSL and ICOS as well as TH 22 cells and IL-22 as new and promising therapeutic targets. This article is protected by copyright. All rights reserved. PMID: 31090221 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 15, 2019 Category: Dermatology Authors: Jiao Q, Qian Q, Liu C, Luo Y, Fang F, Wang M, Ji J, Qian H, Zhang X, Maurer M Tags: Br J Dermatol Source Type: research

Efficacy and clinical significance of omitting blue dye injection during sentinel lymph node biopsy before Mohs micrographic surgery for malignant melanoma of the lower extremities.
CONCLUSIONS: Blue dye injection can be omitted without compromising the accuracy of standard SLNB. Omitting blue dye injection also has marked advantages in MMS for melanoma. This article is protected by copyright. All rights reserved. PMID: 31077333 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 11, 2019 Category: Dermatology Authors: Kim TH, Kim HJ, Seo JW, Song KH Tags: Br J Dermatol Source Type: research

A Brighter Future for Melanoma.
This article is protected by copyright. All rights reserved. PMID: 31077335 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 11, 2019 Category: Dermatology Authors: Russell-Jones R Tags: Br J Dermatol Source Type: research

Standardization of dermoscopic terminology and basic dermoscopic parameters to evaluate in general dermatology (non-neoplastic dermatoses): an expert consensus on behalf of the International Dermoscopy Society.
CONCLUSION: This expert consensus provides a set of standardized basic dermoscopic parameters to follow when evaluating inflammatory, infiltrative and infectious dermatoses. This tool, if adopted by clinicians/researchers of the field, is likely to enhance the reproducibility and comparability of existing and future research findings and uniformly expand the universal knowledge on dermoscopy in general dermatology. This article is protected by copyright. All rights reserved. PMID: 31077336 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 11, 2019 Category: Dermatology Authors: Errichetti E, Zalaudek I, Kittler H, Apalla Z, Argenziano G, Bakos R, Blum A, Braun R, Ioannides D, Lacarrubba F, Lazaridou E, Longo C, Micali G, Moscarella E, Paoli J, Papageorgiou C, Russo T, Scope A, Stinco G, Thomas L, Toncic RJ, Tschandl P, Cabo H, H Tags: Br J Dermatol Source Type: research

Acquired generalized lipodystrophy under immune checkpoint inhibition.
This article is protected by copyright. All rights reserved. PMID: 31077337 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 11, 2019 Category: Dermatology Authors: Haddad N, Vidal-Trecan T, Baroudjian B, Zagdanski AM, Arangalage D, Battistella M, Gautier JF, Lebbe C, Delyon J, PATIO group Tags: Br J Dermatol Source Type: research

Basket-weave structure in the stratum corneum is an important factor for maintaining physiological properties of human skin as studied using reconstructed human epidermis and tape-stripping of human cheek skin.
CONCLUSIONS: Emulsion-A successfully generated the B-W SC in RHE for the first time. This method is suggested to be a useful tool for investigating the physiological significance of the B-W SC in vitro. Determination of Dsg1 content (Dsg1 pixels) in the SC obtained by tape-stripping from human skin can make it possible to study the effects of external stimulants, such as creams/ointments, including cosmetics, on the completeness of the B-W SC in situ without biopsy. This article is protected by copyright. All rights reserved. PMID: 31077338 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 11, 2019 Category: Dermatology Authors: Goto H, Tada A, Ibe A, Kitajima Y Tags: Br J Dermatol Source Type: research

Resolution of severe oral mucosal changes related to vemurafenib therapy with intensive periodontal treatment.
This article is protected by copyright. All rights reserved. PMID: 31074831 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 10, 2019 Category: Dermatology Authors: Shephard MK, Lloyd-Lavery A Tags: Br J Dermatol Source Type: research

Suicidality and risk of suicidality in psoriasis: A critical appraisal of two systematic reviews and meta-analyses.
CONCLUSION: Singh et al. concluded that patients with psoriasis have a significantly higher risk of suicidal ideation, suicide attempts, and completed suicides, while Chi et al concluded that the available limited, very low-quality evidence does not support the notion of an association between psoriasis on the one hand, and suicide, suicidal ideation and attempts on the other. This article is protected by copyright. All rights reserved. PMID: 31074832 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 10, 2019 Category: Dermatology Authors: Matterne U, Baumeister SE, Apfelbacher C Tags: Br J Dermatol Source Type: research

Optimal sunscreen use, during a sun-holiday with a very high UV index, allows vitamin D synthesis without sunburn.
CONCLUSIONS: Sunscreens may be used to prevent sunburn yet allow vitamin D synthesis. A high UVA-PF sunscreen enables significantly higher vitamin D synthesis than a low UVA-PF sunscreen because the former, by default, transmits more UVB than the latter. This article is protected by copyright. All rights reserved. PMID: 31069787 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 8, 2019 Category: Dermatology Authors: Young AR, Narbutt J, Harrison GI, Lawrence KP, Bell M, O'Connor C, Olson P, Grys K, Baczynska K, Rogowski-Tylman M, Wulf HC, Lesiak A, Philipsen PA Tags: Br J Dermatol Source Type: research

Sunscreen photoprotection and vitamin D status.
CONCLUSIONS: Sunscreen use for daily and recreational photoprotection does not compromise vitamin D synthesis, even when applied under optimal conditions. This article is protected by copyright. All rights reserved. PMID: 31069788 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 8, 2019 Category: Dermatology Authors: Passeron T, Bouillon R, Callender V, Cestari T, Diepgen T, Green AC, van der Pols J, Bernard BA, Ly F, Bernerd F, Marrot L, Nielsen M, Verschoore M, Jablonski NG, Young AR Tags: Br J Dermatol Source Type: research

Epidermal AMBRA1 and Loricrin; a paradigm shift in the prognostication and stratification of AJCC stage I melanomas.
Abstract BACKGROUND: Despite the recent update to the AJCC staging criteria for melanoma, this system is still unable to identify truly high-risk stage I tumour subsets. OBJECTIVE: To determine clinical utility of combined epidermal AMBRA1/Loricrin (AMLo) expression as a prognostic biomarker for AJCC stage I cutaneous melanoma. METHODS: Peri-tumoural AMBRA1 expression was evaluated in a retrospective discovery cohort of 76 AJCC I melanomas. Multivariate analysis of AMLo expression was subsequently correlated with clinical outcomes up to 12-years in two independent powered, retrospective validation and qu...
Source: The British Journal of Dermatology - May 6, 2019 Category: Dermatology Authors: Ellis R, Tang D, Nasr B, Greenwood A, McConnell A, Anagnostou ME, Elias M, Verykiou S, Bajwa D, Ewen T, Reynolds NJ, Barrett P, Carling E, Watson G, Armstrong J, Allen AJ, Horswell S, Labus M, Lovat PE Tags: Br J Dermatol Source Type: research

Homeostasis of the sebaceous gland and mechanisms of acne pathogenesis.
CONCLUSIONS: Future research should seek to establish the relative importance, and causative relationships, of altered sebum production, sebum composition, inflammation and abnormal differentiation of sebaceous progenitors to the process of comedo formation in acne. Such an understanding will allow for therapeutic targeting of regulatory factors that control SG homeostasis, with the aim of treating acne. PMID: 31056753 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 6, 2019 Category: Dermatology Authors: Clayton RW, Göbel K, Niessen CM, Paus R, van Steensel MAM, Lim X Tags: Br J Dermatol Source Type: research

Direct infant UV light exposure is associated with eczema and immune development: A Critical Appraisal.
CONCLUSIONS: Vitamin D supplementation in high-risk infants increased Vitamin D levels but did not reduce eczema. Exploratory post-hoc analyses in a non-randomised subset showed an association between greater direct UV light exposure and reduction of eczema. The authors claim that "our findings indicate that UV light exposure appears more beneficial than vitamin D supplementation as an allergy prevention strategy in early life". This article is protected by copyright. All rights reserved. PMID: 31054159 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 3, 2019 Category: Dermatology Authors: Maslin D, Veitch D, Williams HC Tags: Br J Dermatol Source Type: research

Changing our microbiome: Probiotics in dermatology.
CONCLUSIONS: Oral and topical probiotics appear to be effective for the treatment of certain inflammatory skin diseases and demonstrate a promising role in wound healing and skin cancer. However, more studies are needed to confirm these results. This article is protected by copyright. All rights reserved. PMID: 31049923 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 3, 2019 Category: Dermatology Authors: Yu Y, Dunaway S, Champer J, Kim J, Alikhan A Tags: Br J Dermatol Source Type: research

Using the Localized Scleroderma Cutaneous Assessment Tool (LoSCAT) to classify morphea by severity and identify clinically significant change.
CONCLUSIONS: The LoSCAT can be used to classify morphea patients by disease severity and identify clinically significant improvement in activity. This article is protected by copyright. All rights reserved. PMID: 31049928 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 3, 2019 Category: Dermatology Authors: Teske NM, Jacobe HT Tags: Br J Dermatol Source Type: research

Developing classification criteria for skin-predominant dermatomyositis: the Delphi process.
CONCLUSION: This project is a key step in the development of prospectively validated classification criteria that will create a more inclusive population of DM patients for clinical research. This article is protected by copyright. All rights reserved. PMID: 31049930 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 3, 2019 Category: Dermatology Authors: Concha JSS, Pena S, Gaffney RG, Patel B, Tarazi M, Kushner CJ, Merola JF, Fiorentino D, Dutz JP, Goodfield M, Nyberg F, Volc-Platzer B, Fujimoto M, Ang CC, Skin Myositis Delphi Group, Werth VP Tags: Br J Dermatol Source Type: research

CD11b+ cells markedly express the itch cytokine interleukin 31 in polymorphic light eruption.
This article is protected by copyright. All rights reserved. PMID: 31049931 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 3, 2019 Category: Dermatology Authors: Patra V, Strobl J, Gruber-Wackernagel A, Vieyra-Garcia P, Stary G, Wolf P Tags: Br J Dermatol Source Type: research

Advanced-stage Mycosis Fungoides. Role of STAT3, NFKB and NFAT pathways.
CONCLUSIONS: Our results show that STAT3 is activated in advanced cases and associated with large-cell transformation, while the activation of NFAT and NFκB is maintained throughout the disease. These findings could have important diagnostic and therapeutic implications. This article is protected by copyright. All rights reserved. PMID: 31049933 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 3, 2019 Category: Dermatology Authors: Pérez C, Mondéjar R, García-Díaz N, Cereceda L, León A, Montes S, Durán Vian C, Pérez Paredes MG, González-Morán A, Alegre de Miguel V, Sanz Anquela JM, Frias J, Limeres MA, González LM, Martín Dávila F, Beltrán M, Mollejo M, Méndez JR, Gonz Tags: Br J Dermatol Source Type: research

Hair loss among transgender and gender-nonbinary patients: a cross-sectional study.
This article is protected by copyright. All rights reserved. PMID: 31049935 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 3, 2019 Category: Dermatology Authors: Marks DH, Hagigeorges D, Manatis-Lornell AJ, Dommasch E, Senna MM Tags: Br J Dermatol Source Type: research

Refining the dermatological spectrum in primary immunodeficiency: MALT1 deficiency mimicking Netherton- and Omenn syndrome.
This article is protected by copyright. All rights reserved. PMID: 31049936 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 3, 2019 Category: Dermatology Authors: Wiegmann H, Reunert J, Metze D, Marquardt T, Engel T, Kunde V, Ehl S, Foell D, van den Heuven I, Oji V, Wittkowski H Tags: Br J Dermatol Source Type: research

Tumor cell-derived complement components C1r and C1s promote growth of cutaneous squamous cell carcinoma.
CONCLUSIONS: These results provide evidence for the role of tumor cell-derived C1r and C1s in the progression of cSCC and identify them as biomarkers and putative therapeutic targets in cSCC. This article is protected by copyright. All rights reserved. PMID: 31049937 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 3, 2019 Category: Dermatology Authors: Riihilä P, Viiklepp K, Nissinen L, Farshchian M, Kallajoki M, Kivisaari A, Meri S, Peltonen J, Peltonen S, Kähäri VM Tags: Br J Dermatol Source Type: research