Three cases of recalcitrant cutaneous warts treated with quadrivalent human papillomavirus vaccine: the HPV type may not determine the outcome.
Abstract To the best of our knowledge, 11 reports have described the efficacy of the bivalent human papillomavirus vaccine (BHPV) and quadrivalent human papillomavirus vaccine (QHPV) in the treatment of cutaneous warts1-3 . Nine reports described the complete regression of cutaneous warts in all patients treated with BHPV or QHPV (total of 16 cases). On the other hand, Abeck and Fölster-Holst2 reported that 10 of 16 patients were cured, with younger patients having better cure rates. PMID: 31675436 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 1, 2019 Category: Dermatology Authors: Hayashi A, Matsumoto K, Mitsuishi T Tags: Br J Dermatol Source Type: research

Opposing effects of STAT3 targeting in epidermolysis bullosa.
uml;m A Abstract Dystrophic epidermolysis bullosa (DEB) is a skin blistering disease caused by mutations in the COL7A1 gene encoding the anchoring fibril-constituent collagen VII.1 Secondary to skin fragility, DEB manifests as chronic wounds and progressive soft tissue fibrosis. As a consequence of a chronically injured and stiffened dermal microenvironment people with severe DEB are prone to develop early-onset metastatic cutaneous squamous cell carcinomas (cSCCs).1,2 Dermal fibrosis in DEB is paradigmatic of injury- and inflammation-driven activation of fibrogenic processes2 (and references therein). PMID: ...
Source: The British Journal of Dermatology - November 1, 2019 Category: Dermatology Authors: Mittapalli VR, Kühl T, Kuzet SE, Gretzmeier C, Kiritsi D, Gaggioli C, Bruckner-Tuderman L, Nyström A Tags: Br J Dermatol Source Type: research

Topically applied treatments for external genital warts in non-immunocompromised patients: A systematic review and network meta-analysis.
CONCLUSIONS: Conventional modalities were efficacious and well tolerated, although each of them had their advantages and disadvantages. Additional efficacy and safety studies are warranted for unconventional agents. PMID: 31675442 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 1, 2019 Category: Dermatology Authors: Jung JM, Jung CJ, Lee WJ, Won CH, Lee MW, Choi JH, Chang SE Tags: Br J Dermatol Source Type: research

Image Gallery: Zosteriform metastasis from melanoma.
ora J PMID: 31663604 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 30, 2019 Category: Dermatology Authors: Aguilar JA, Irurzun AL, Bayona JIY, Rodríguez MA, de Espronceda Ezquerro IM, Sarriugarte Aldecoa-Otalora J Tags: Br J Dermatol Source Type: research

Comparison of real costs in the French healthcare system in newly diagnosed pemphigus patients: first-line treatment with rituximab versus standard corticosteroid regimen. Data of a national multicentre trial.
CONCLUSIONS: First-line treatment of pemphigus with rituximab results in a slightly greater cost compared with a standard CS regimen. PMID: 31657454 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 28, 2019 Category: Dermatology Authors: Hébert V, Vermeulin T, Tanguy L, Tedbirt B, Mignard C, Bénichou J, Joly P Tags: Br J Dermatol Source Type: research

Adjusted treatment COMPArisons between guSelkumab and uStekinumab for treatment of moderate-to-severe plaque psoriasis: the COMPASS Analysis.
CONCLUSION: Adjusted analyses leveraging IPD demonstrates that guselkumab has a significantly higher probability of achieving and maintaining PASI treatment response through week 40 compared with ustekinumab. PMID: 31652347 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 25, 2019 Category: Dermatology Authors: Diels J, Thilakarathne P, Cameron C, McElligott S, Schubert A, Puig L Tags: Br J Dermatol Source Type: research

Severe Early-Onset Manifestations of Pseudoxanthoma Elasticum Resulting from the Cumulative Effects of Several Deleterious Mutations in the ENPP1, ABCC6 and HBB Genes: Transient Improvement in Ectopic Calcification with Sodium Thiosulfate.
Abstract Pseudoxanthoma Elasticum (PXE) is a rare disorder characterized by fragmentation and progressive calcification of elastic fibres in connective tissues. Overlap has been reported between the inherited PXE phenotype associated with ENPP1, ABCC6 or NT5E mutations and acquired PXE clinical manifestations associated with haemoglobinopathies induced by HBB mutations. No treatment is available for PXE to date. A young boy presented with severe early-onset systemic calcifications occurring in the skin as elastosis perforans serpiginosa (EPS) and in the arteries causing mesenteric and limb ischemia. Molecular and ...
Source: The British Journal of Dermatology - October 24, 2019 Category: Dermatology Authors: Omarjee L, Nitschke Y, Verschuere S, Bourrat E, Vignon MD, Navasiolava N, Leftheriotis G, Kauffenstein G, Rutsch F, Vanakker OM, Martin L Tags: Br J Dermatol Source Type: research

Autoimmune disease development before and after cutaneous lupus erythematosus diagnosis.
Abstract Dear Editor, previous studies have shown patients with systemic lupus erythematosus (SLE) harbor an increased risk for developing additional autoimmune diseases. We recently reported in a cross-sectional study that 17.8% of cutaneous lupus erythematosus (CLE) patients without SLE had co-existing autoimmune disease(s). Thus, we conducted a retrospective cohort study to characterize the timing and prevalence of autoimmune diseases in patients in relation to their CLE diagnosis. We also identified demographic and clinical factors associated with additional autoimmune conditions. PMID: 31647114 [PubMed -...
Source: The British Journal of Dermatology - October 24, 2019 Category: Dermatology Authors: Shi KY, Kunzler E, Hynan LS, Chong BF Tags: Br J Dermatol Source Type: research

Update on Pachyonychia Congenita Research.
Abstract Pachyonychia congenita (PC) research is gathering pace, with a number of important recent advances supported by the International Pachyonychia Congenita Consortium, (IPCC). Highlights from this year's IPCC symposium include research presented by scientists studying keratin biology and structure, inflammation in PC, and the latest advances in therapeutics including keratin modification via existing chemical compounds, nucleic acid delivery and stem cell therapy. PMID: 31648361 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 24, 2019 Category: Dermatology Authors: Funk T, Hansen CD, Paller A, O'Toole E Tags: Br J Dermatol Source Type: research

Under-screening of depression in United States outpatients with atopic dermatitis and psoriasis.
We examined rates of depression screening among in psoriasis and AD in United States outpatients. PMID: 31648383 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 24, 2019 Category: Dermatology Authors: Singh P, Silverberg JI Tags: Br J Dermatol Source Type: research

Knowing the score - it's not quite enough anymore.
PMID: 31646617 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 23, 2019 Category: Dermatology Authors: Howells L Tags: Br J Dermatol Source Type: research

Oxytosin as a novel antidegenerative?
PMID: 31646625 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 23, 2019 Category: Dermatology Authors: Faragher RGA Tags: Br J Dermatol Source Type: research

Real protection of facial sunscreens.
Abstract The harmful effects of solar radiation exposure on human skin are well known (1). Both ultraviolet B (UVB) and ultraviolet A (UVA) radiation induce DNA damage, leading the formation of molecules, such as pyrimidine dimers and 6-4 photoproducts, which play a key role in the development of skin cancer (2). Despite the increasing awareness of the harmful effects of the sun and use of sun protection, 70%-90% of basal cell carcinomas (BCCs) develop in sun-exposed head and neck regions, and 5%-10% of all skin cancers occur on the eyelids (3). PMID: 31637703 [PubMed - as supplied by publisher] (Source: The ...
Source: The British Journal of Dermatology - October 21, 2019 Category: Dermatology Authors: Portilho L, Leonardi GR Tags: Br J Dermatol Source Type: research

Clinical characteristics, symptoms, and burden of psoriasis and atopic dermatitis in adults.
CONCLUSION: We identified important similarities and differences in the clinical characteristics of adults with psoriasis and AD; these should help clinicians to prioritize and improve patient management. PMID: 31630393 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 20, 2019 Category: Dermatology Authors: Egeberg A, Griffiths CEM, Williams HC, Andersen YMF, Thyssen JP Tags: Br J Dermatol Source Type: research

Age-and gender-appropriate cancer screening risks missing most occult malignancies in young dermatomyositis patients.
Abstract Dermatomyositis (DM) is an autoimmune disease associated with malignancy. Reported incidence of cancer ranges from 7-30% in adult DM patients, with most studies clustered around 15-20% (1). The risk is elevated above the baseline population 3 years prior and 5 years following DM diagnosis. The period of greatest risk occurs in the first 3 years following diagnosis. Age>50 consistently shows strong association with the development of cancer. A retrospective analysis found most cancers were identified using blind screening, rather than symptom-guided or age-appropriate screenings. PMID: 31630395 [Pu...
Source: The British Journal of Dermatology - October 20, 2019 Category: Dermatology Authors: Kundrick A, Kitts S, Maczuga S, Olsen N, Foulke G Tags: Br J Dermatol Source Type: research

Acral lentiginous melanoma: differences in survival compared to other subtypes.
Abstract Dear editor, acral lentiginous melanoma (ALM) is typically diagnosed at an advanced stage which may be due its unique presentation. Studies have evaluated whether the ALM subtype is an independent prognostic factor with conflicting results. Previous reports have been limited by small numbers and lacked adjustment for confounders. Therefore, the aim of this study was to compare melanoma specific survival (MSS) of ALM with other subtypes. PMID: 31628856 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 19, 2019 Category: Dermatology Authors: Howard M, Xie C, Wee E, Wolfe R, McLean C, Kelly JW, Pan Y Tags: Br J Dermatol Source Type: research

Responsiveness of quality of life measures in patients with peripheral vascular malformations: the OVAMA project.
Abstract INTRODUCTION: The OVAMA (Outcome measures for vascular malformations) project determined quality of life (QoL) as a core outcome domain for patients with vascular malformations. In order to measure how current therapeutic strategies alter QoL in these patients, a patient-reported outcome measurement (PROM) responsive to changes in QoL is required. We therefore assessed the responsiveness of two widely used generic QoL PROMs, the Medical Outcomes Study Short Form 36 (SF-36) and Skindex-29, in adult patients with vascular malformations. METHODS: In an international multicentre prospective study, treate...
Source: The British Journal of Dermatology - October 19, 2019 Category: Dermatology Authors: Lokhorst MM, Horbach SER, Waner M, O TM, van der Vleuten CJM, Mokkink LB, van der Horst CMAM, Spuls PI Tags: Br J Dermatol Source Type: research

The effectiveness of two silicone dressings for sacral and heel pressure ulcer prevention in high risk intensive care unit patients compared to no dressings: a randomized controlled parallel-group trial.
CONCLUSION: Results indicate that the application of dressings in addition to standard prevention in high risk intensive care unit patients is effective in preventing pressure ulcers at the heels and sacrum. PMID: 31628863 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 19, 2019 Category: Dermatology Authors: Hahnel E, El Genedy M, Tomova-Simitchieva T, Hauß A, Stroux A, Lechner A, Richter C, Akdeniz M, Blume-Peytavi U, Löber N, Kottner J Tags: Br J Dermatol Source Type: research

Secukinumab for patients failing previous TNF α-inhibitor therapy: results of a randomised open-label study (Signature).
Secukinumab for patients failing previous TNFα-inhibitor therapy: results of a randomised open-label study (Signature). Br J Dermatol. 2019 Oct 18;: Authors: Warren RB, Barker J, Finlay AY, Burden AD, Kirby B, Armendariz Y, Williams R, Hatchard C, Khare S, Griffiths CEM Abstract BACKGROUND: Efficacy data on therapies for psoriasis patients who have failed tumour necrosis factor (TNF)α-inhibitor therapy is limited. OBJECTIVES: To determine the effectiveness and tolerability of secukinumab, an IL-17A inhibitor, in patients with moderate/severe chronic plaque psoriasis with documented ef...
Source: The British Journal of Dermatology - October 18, 2019 Category: Dermatology Authors: Warren RB, Barker J, Finlay AY, Burden AD, Kirby B, Armendariz Y, Williams R, Hatchard C, Khare S, Griffiths CEM Tags: Br J Dermatol Source Type: research

Understanding actinic keratosis to reduce squamous cell carcinoma incidence.
PMID: 31621060 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 16, 2019 Category: Dermatology Authors: O'Shaughnessy RFL Tags: Br J Dermatol Source Type: research

Vitiligo and skin cancer: is it a question of ethnicity?
PMID: 31621061 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 16, 2019 Category: Dermatology Authors: Gran S Tags: Br J Dermatol Source Type: research

New therapeutics for leprosy.
PMID: 31621065 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 16, 2019 Category: Dermatology Authors: Walker SL Tags: Br J Dermatol Source Type: research

Image Gallery: White piedra.
PMID: 31617200 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 15, 2019 Category: Dermatology Authors: Kumetz EA, Rivard SC Tags: Br J Dermatol Source Type: research

Measuring clinician-machine agreement in differential diagnoses for dermatology.
Abstract Artificial intelligence (AI) algorithms have generated significant interest as a tool to assist in clinical workflows, particularly in image-based diagnostics such as melanoma detection.1,2 These algorithms typically answer narrowly-scoped questions, such as "is this lesion malignant?" By contrast, dermatologists frequently tackle less structured diagnostic questions, such as "what is this rash?" In practice, evaluating clinical cases often involves integrating insights from morphology, context, and history to determine a ranked-ordered list of possible diagnoses, i.e. a differential d...
Source: The British Journal of Dermatology - October 14, 2019 Category: Dermatology Authors: Eng C, Liu Y, Bhatnagar R Tags: Br J Dermatol Source Type: research

Pathogen identification by shotgun metagenomics of patients with necrotising soft-tissue infections.
group Abstract BACKGROUND: Necrotising soft-tissue infections (NSTIs) are life-threatening, requiring broad-spectrum antibiotics. Their etiological diagnosis can be limited by poor performance of cultures and administration of antibiotics before surgery. OBJECTIVES: We aimed to: (i) compare 16S-targeted metagenomics (TM) and unbiased semi-quantitative pan-microorganism DNA- and RNA-based shotgun metagenomics (SM) with cultures, (ii) identify patients who best benefit from metagenomics approaches, and (iii) detect the microbial pathogens in surrounding non-necrotic "healthy" tissues by SM metagenomic...
Source: The British Journal of Dermatology - October 14, 2019 Category: Dermatology Authors: Rodriguez C, Jary A, Hua C, Woerther PL, Bosc R, Desroches M, Sitterlé E, Gricourt G, De Prost N, Pawlotsky JM, Chosidow O, Sbidian E, Decousser JW, multidisciplinary necrotising fasciitis study group Tags: Br J Dermatol Source Type: research

Developing risk prediction models for melanoma: balancing better predictive value with ease of clinical implementation.
PMID: 31608432 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 13, 2019 Category: Dermatology Authors: Toland AE Tags: Br J Dermatol Source Type: research

Open Label Pilot Study of 2% Tofacitinib for the Treatment of Refractory Vitiligo.
Abstract Treatment options for vitiligo are limited and many cases remain refractory to first and second line treatments. Interferon-gamma signaling mediated by Janus kinase (JAK) has been implicated in the pathogenesis of vitiligo.1 Systemic administration of tofacitinib, a potent JAK1/3 inhibitor, has been effective in treating vitiligo in case reports,2 however, it is associated with infections, malignancies, cytopenias, gastrointestinal perforations, and hyperlipidemia in some patients with rheumatoid arthritis. PMID: 31605536 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 12, 2019 Category: Dermatology Authors: Mobasher P, Guerra R, Jiayang Li S, Frangos J, Ganesan AK, Huang V Tags: Br J Dermatol Source Type: research

Standardising the classification of skin tears: validity and reliability testing of the International Skin Tear Advisory Panel (ISTAP) Classification System in 44 countries.
CONCLUSIONS: The ISTAP Classification System is supported by evidence for validity and reliability. The ISTAP Classification System should be used for a systematic assessment and reporting of skin tears in clinical practice and research globally. PMID: 31605618 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 12, 2019 Category: Dermatology Authors: Van Tiggelen H, LeBlanc K, Campbell K, Woo K, Baranoski S, Chang YY, Dunk AM, Gloeckner M, Hevia H, Holloway S, Idensohn P, Karadağ A, Koren E, Kottner J, Langemo D, Ousey K, Pokorná A, Romanelli M, Santos VLCG, Smet S, Tariq G, Van den Bussche K, Van H Tags: Br J Dermatol Source Type: research

The presence of sulfites in "natural rubber latex" and "synthetic" rubber gloves: an experimental pilot study.
The presence of sulfites in "natural rubber latex" and "synthetic" rubber gloves: an experimental pilot study. Br J Dermatol. 2019 Oct 12;: Authors: Dendooven E, Darrigade AS, Foubert K, Pieters L, Lambert J, Goossens A, Aerts O Abstract Sulfites are widely used as antioxidants and preservatives (1-3), but are also frequent contact sensitizers. Indeed, more than 1% of subjects routinely patch-tested to sodium metabisulfite (SMB) 1% diluted in petrolatum (pet.), the best marker to detect contact allergy to sulfites (1), are sensitized to them (1, 4). SMB 1% pet., has recently been p...
Source: The British Journal of Dermatology - October 12, 2019 Category: Dermatology Authors: Dendooven E, Darrigade AS, Foubert K, Pieters L, Lambert J, Goossens A, Aerts O Tags: Br J Dermatol Source Type: research

Mosaic Variant in ATP2C1 Presenting as Relapsing Linear Acantholytic Dermatosis: Case Report.
Abstract Relapsing Linear Acantholytic Dermatosis (RLAD) is a rare disease that manifests as recurring episodes of crusted and vesicular lesions distributed in a Blaschkoid pattern with histology resembling Hailey-Hailey or Darier's disease. RLAD is hypothesized to be a mosaic form of a known acantholytic disorder, but this hypothesis has lacked genetic conformation. To determine the genetic abnormalities causing RLAD, we performed exome sequencing of affected tissue and blood in a single subject. Exome sequencing of an punch biopsy revealed a c.238A>T, p.(Lys80*) variant in ATP2C1 found in 26% of the reads fro...
Source: The British Journal of Dermatology - October 12, 2019 Category: Dermatology Authors: Katzman JA, Chavan R, Holliday A, Coman G, Grider D, Kolodney MS Tags: Br J Dermatol Source Type: research

The prevailing dermoscopic vascular pattern in melanoma is influenced by tumor thickness and pigmentation type.
Abstract In non-pigmented skin tumors the diagnosis is mainly based on the evaluation of the vascular morphology and vessels´ distribution dermoscopically [1-4]. However, up to date, no study formally correlated the prevailing vascular morphology with the thickness of melanoma according to Breslow and amount of pigmentation. PMID: 31605621 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 12, 2019 Category: Dermatology Authors: Deinlein T, Longo C, Schulter G, Pizzichetta MA, Zalaudek I Tags: Br J Dermatol Source Type: research

Longitudinal analysis of the effect of water hardness on atopic eczema: evidence for gene-environment interaction.
CONCLUSIONS: There is evidence of an interaction between water hardness and FLG gene mutations in the development of infantile AE. PMID: 31599965 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 10, 2019 Category: Dermatology Authors: Jabbar-Lopez ZK, Craven J, Logan K, Greenblatt D, Marrs T, Radulovic S, McLean WHI, Lack G, Strachan DP, Perkin MR, Peacock JL, Flohr C Tags: Br J Dermatol Source Type: research

Image Gallery: Widespread erosive tinea corporis mimicking autoimmune bullous dermatoses in a patient with lung cancer.
PMID: 31598958 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 9, 2019 Category: Dermatology Authors: Shen WC, Chang Liao NF, Wu PY Tags: Br J Dermatol Source Type: research

Image Gallery: Antihelix red-violaceous macules in juvenile dermatomyositis associated with antimelanoma differentiation-associated protein 5 antibody.
PMID: 31598963 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 9, 2019 Category: Dermatology Authors: Nagai H, Nishigori C Tags: Br J Dermatol Source Type: research

Image Gallery: Shingle-induced Koebner phenomenon.
PMID: 31598966 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 9, 2019 Category: Dermatology Authors: Gao J, Wang R Tags: Br J Dermatol Source Type: research

No Evidence that Impaired Notch Signaling Differentiates Hidradenitis Suppurativa From Other Inflammatory Skin Diseases.
Abstract The molecular pathogenesis of Hidradenitis Suppurativa (HS) is purported to involve Notch dysregulation secondary to sequence variants in components of the gamma secretase complex (GSC)1 . However, Notch dysregulation has also been identified in keratinocytes of other inflammatory dermatoses including psoriasis2 and atopic dermatitis2 . Animal knockout models of components of the GSC with resultant Notch dysregulation result in the development of dermal cysts and histological features of follicular occlusion, suggesting that aberrant Notch signaling is linked to the unique clinical and histological manife...
Source: The British Journal of Dermatology - October 8, 2019 Category: Dermatology Authors: Frew JW, Navrazhina K Tags: Br J Dermatol Source Type: research

Dupilumab in adolescents with uncontrolled moderate-to-severe atopic dermatitis: results from a phase IIa open-label trial and subsequent phase III open-label extension.
CONCLUSIONS: In adolescents with moderate-to-severe AD, dupilumab's pharmacokinetic profile was similar to that in adults. These 52-week safety and efficacy data support long-term use of dupilumab in this patient population. What's already known about this topic? Adolescents with moderate-to-severe atopic dermatitis (AD) have high unmet medical need, with significant disease burden and limited treatment options. Dupilumab (monoclonal antibody against interleukin-4 receptor α) is approved for the treatment of adolescents with moderate-to-severe AD who are inadequately responsive to standard of care (U.S.A.) or candida...
Source: The British Journal of Dermatology - October 8, 2019 Category: Dermatology Authors: Cork MJ, Thaçi D, Eichenfield LF, Arkwright PD, Hultsch T, Davis JD, Zhang Y, Zhu X, Chen Z, Li M, Ardeleanu M, Teper A, Akinlade B, Gadkari A, Eckert L, Kamal MA, Ruddy M, Graham NMH, Pirozzi G, Stahl N, DiCioccio AT, Bansal A Tags: Br J Dermatol Source Type: research

The psychological functioning of children with Epidermolysis Bullosa (EB) and its relationship with specific aspects of disease.
Abstract Epidermolysis Bullosa (EB) is a group of genetic conditions resulting in skin and mucosal membrane fragility. EB is characterised by chronic wounds and scarring, consequent functional limitations and high levels of pain. In its most severe forms, life expectancy is significantly foreshortened. PMID: 31587254 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 6, 2019 Category: Dermatology Authors: Soon K, Mason R, Martinez AE, Mellerio JE Tags: Br J Dermatol Source Type: research

Aplasia cutis congenita associated with a heterozygous loss-of-function UBA2 variant.
Abstract Aplasia cutis congenita (ACC) is an isolated or syndromic congenital skin defect with the absence of skin and occasionally subcutaneous tissue, commonly seen as localised lesions on the scalp vertex. Syndromic ACC is associated with limb, neurological, cardiovascular, gastrointestinal, genitourinary, placental, and dermatological anomalies.1 Familial reports of ACC suggest a Mendelian inheritance although the underlying genetics has not been completely clarified.2 Here we report a family with mother and son both affected by ACC and found to have a heterozygous variant in UBA2. PMID: 31587267 [PubMed ...
Source: The British Journal of Dermatology - October 6, 2019 Category: Dermatology Authors: Wang Y, Dupuis L, Jobling R, Kannu P Tags: Br J Dermatol Source Type: research

Consensus definitions of disease activity in hidradenitis suppurativa: crossing the semantic gap.
PMID: 31583685 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 3, 2019 Category: Dermatology Authors: Navrazhina K, Frew JW Tags: Br J Dermatol Source Type: research

The pharmacology of itch.
PMID: 31578709 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 3, 2019 Category: Dermatology Authors: Ingram JR, Ahluwalia A Tags: Br J Dermatol Source Type: research

Common methodological pitfalls and new developments in systematic review meta-analyses.
PMID: 31576568 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 1, 2019 Category: Dermatology Authors: Leonardi-Bee J, Flohr C, van Zuuren EJ, Le Cleach L, Hollestein LM Tags: Br J Dermatol Source Type: research

Nonsteroidal anti-inflammatory drug associations with nonmelanoma skin cancer - the saga continues.
PMID: 31576570 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 1, 2019 Category: Dermatology Authors: Rundle CW, Dellavalle RP Tags: Br J Dermatol Source Type: research

Acne in the 21st century.
PMID: 31576571 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 1, 2019 Category: Dermatology Authors: van Steensel MAM Tags: Br J Dermatol Source Type: research

Are demodex mites the best target for rosacea treatments?
PMID: 31576573 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 1, 2019 Category: Dermatology Authors: Thyssen JP Tags: Br J Dermatol Source Type: research

Validation of an Oral Disease Severity Score (ODSS) tool for use in oral mucous membrane pemphigoid.
Abstract BACKGROUND: Mucous membrane pemphigoid (MMP) is a rare autoimmune bullous disease predominantly affecting the oral mucosa. Optimal management relies upon thorough clinical assessment and documentation at each visit. OBJECTIVES: The primary aim of this study was to validate the Oral Disease Severity Score (ODSS) for the assessment of oral involvement in MMP. We also compared its inter- and intra-observer reliability with the oral parts of the Mucous Membrane Pemphigoid Disease Area Index (MMPDAI), Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and Physician's Global Assessment (PGA). ME...
Source: The British Journal of Dermatology - September 30, 2019 Category: Dermatology Authors: Ormond M, McParland H, Thakrar P, Donaldson ANA, Andiappan M, Cook RJ, Escudier ME, Higham J, Hullah E, McMillan R, Taylor J, Shirlaw PJ, Challacombe SJ, Setterfield JF Tags: Br J Dermatol Source Type: research

Old mitochondria accumulate in pachyonychia congenita.
PMID: 31571193 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 30, 2019 Category: Dermatology Authors: Vetter A, Magin TM Tags: Br J Dermatol Source Type: research

Image Gallery: Giant rhinophyma.
PMID: 31571194 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 30, 2019 Category: Dermatology Authors: Qian YT, Ma JY, Vano-Galvan S, Ma DL Tags: Br J Dermatol Source Type: research

Can the dose and dosing interval of biologics be optimized?
PMID: 31571195 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 30, 2019 Category: Dermatology Authors: Morita A, Ikumi K Tags: Br J Dermatol Source Type: research

Psoriasis, gut and microbiome.
PMID: 31571198 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 30, 2019 Category: Dermatology Authors: Alexeyev O Tags: Br J Dermatol Source Type: research