Mapping the burden of onchocercal skin disease.
Abstract Onchocerciasis is a neglected tropical disease caused by a nematode parasite, Onchocerca volvulus, and transmitted by bites of Simulium blackflies which breed near fast-flowing rivers. In humans thousands of microfilariae (immature worms) migrate to the skin and eyes where they cause pathology. Historically, much research was devoted to the serious effect of blindness, from which the disease earns its alternative name of "river blindness". Mapping the burden of onchocercal skin disease (OSD) was expedited by the development of a clinical classification and grading system which facilitated compar...
Source: The British Journal of Dermatology - April 16, 2020 Category: Dermatology Authors: Murdoch ME Tags: Br J Dermatol Source Type: research

Phototherapeutic approach to dermatological patients during the 2019 Coronavirus pandemic: Real-life Data from the Italian Red Zone.
one A Abstract Since the novel Coronavirus 2019, also known as COVID-19 or SARS CoV-2, crossed the Chinese borders and became pandemic, Italy has rapidly become the country with the highest number of patient deaths as well as confirmed and/or hospitalized patients, after China [1-2]. On March 12th Italy was declared a red-zone and special protocols were enacted to limit the spread of the virus. Although COVID-19 does not have epidermotropism, cutaneous manifestations in Cov-19 positive patients have been reported [3] and departments of dermatology are considered at high risk [4] and were ordered to admit only pati...
Source: The British Journal of Dermatology - April 16, 2020 Category: Dermatology Authors: Pacifico A, Ardigò M, Frascione P, Damiani G, Morrone A Tags: Br J Dermatol Source Type: research

Hidradenitis suppurativa publications are sparse in front-line specialties.
Abstract Hidradenitis suppurativa (HS) is a debilitating inflammatory disease that is understudied, underfunded, and notable for mean diagnostic delay of approximately 7 years. We aimed to characterize annual HS-related publications across medical fields of study caring for HS in order to measure the extent of awareness, education and ongoing research in this area. PMID: 32294228 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 14, 2020 Category: Dermatology Authors: Martins DB, Ayanruoh L, Paul M, Shukla N, Naik HB Tags: Br J Dermatol Source Type: research

Leptin induces interleukin-6 production in keratinocytes via decreased expression of caveolin-1: a possible link between obesity and psoriatic inflammation.
Abstract It has been reported that obesity may be an aggravating factor for psoriasis. However, its pathological mechanism remains elusive. The adipocyte-derived hormone leptin primarily controls energy homeostasis by regulating appetite and modulates immunity. Strikingly, serum leptin levels are elevated in obese patients and positively correlate with body mass index. Additionally, leptin levels also correlate with severity of psoriasis, and knocking out leptin suppresses imiquimod-induced psoriatic inflammation in mice. PMID: 32294231 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 14, 2020 Category: Dermatology Authors: Watanabe Y, Yamaguchi Y, Takamura N, Komitsu N, Aihara M Tags: Br J Dermatol Source Type: research

Cost and Diagnostic Characteristics of Toxicodendron Dermatitis in the United States: A retrospective cross-sectional analysis.
Abstract Toxicodendron dermatitis (TD), or allergic contact dermatitis (ACD) due to poison ivy, oak, and sumac, is the most common cause of ACD in the United States (US). Affecting 10-15 million people every year, TD causes a pruritic, erythematous rash 24-48 hours following skin contact with urushiol, the compound found on poison ivy, oak, and sumac plants responsible for producing an allergic response. PMID: 32294234 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 14, 2020 Category: Dermatology Authors: Zomorodi N, Butt M, Maczuga S, Marks J, Flamm A Tags: Br J Dermatol Source Type: research

High and discordant prevalences of clinical and sonographic enthesitis in patients with hidradenitis suppurativa.
Abstract The prevalence of spondyloarthritis (SpA) reported among patients with hidradenitis suppurativa (HS) ranges from 2.3 to 28.2 %, depending on the diagnostic method used.1 A key feature of SpA and one of the European Spondyloarthropathy Study Group (ESSG) diagnostic criteria for this group of diseases is enthesitis; inflammation at insertion of tendons, ligaments, and capsules. However, pain at an entheseal site is non-specific and does not always indicate inflammation. PMID: 32294241 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 14, 2020 Category: Dermatology Authors: van Straalen KR, Boeren AMP, Wervers K, Prens E, Vis M Tags: Br J Dermatol Source Type: research

Disease characteristics in female and male Patients with Hidradenitis Suppurativa.
en SF Abstract The continuously growing interest in the study of gender medicine in the last years has led to increased awareness of the differences between men and women in the clinical presentation, pathophysiology, management, and prognosis of a wide variety of diseases, including skin diseases. Gender differences in disease characteristics can be influenced by numerous factors, e.g. the effect of sex hormones, anatomy, physiology, and genetics. Variances in skin structure and physiology between the sexes can also contribute to different expressions of certain skin disorders. PMID: 32294242 [PubMed - as su...
Source: The British Journal of Dermatology - April 14, 2020 Category: Dermatology Authors: Jørgensen AR, Ring HC, Yao Y, Thomsen SF Tags: Br J Dermatol Source Type: research

Dapsone therapy for hidradenitis suppurativa.
Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory condition of apocrine gland-bearing skin that is characterised by recurrent painful nodules, abscess and sinus tract formation. Estimates of the prevalence of HS are highly variable, but it is believed to affect around 1% of the population in Europe. Existing treatments for HS include antimicrobial, immunomodulatory and immunosuppressive agents. PMID: 32294243 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 14, 2020 Category: Dermatology Authors: Murray G, Hollywood A, Kirby B, Hughes R Tags: Br J Dermatol Source Type: research

Treatment of severe cutaneous adverse reaction with tocilizumab.
Abstract A 29-year-old Chinese male with recurrent alveolar soft part sarcoma of the tongue metastatic to lung presented with fever and rash (Figure 1a). He underwent glossectomy and adjuvant radiotherapy, complicated by recurrence and abscess with sinus tract formation on the right neck. Current therapy included ipilimumab 3mg/kg and nivolumab 1mg/kg (completed 9 cycles; last dose two days before admission), and cabozantinib 40mg daily (held for six weeks due to sinus tract in the neck). PMID: 32291751 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 13, 2020 Category: Dermatology Authors: Hibler BP, Markova A Tags: Br J Dermatol Source Type: research

Long-term efficacy and safety of brodalumab in psoriasis through 120 weeks and after withdrawal and retreatment: subgroup analysis of a randomised phase 3 trial (AMAGINE-1).
CONCLUSIONS: These findings indicate that brodalumab is efficacious and safe for continuous long-term treatment of psoriasis and support potential for response after discontinuation and retreatment. PMID: 32286683 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 13, 2020 Category: Dermatology Authors: Papp K, Menter A, Leonardi C, Soung J, Weiss S, Pillai R, Jacobson A Tags: Br J Dermatol Source Type: research

Choosing a biologic for psoriasis: is it a sprint or a marathon?
PMID: 32285438 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Veysey E Tags: Br J Dermatol Source Type: research

Nivolumab-induced toxic epidermal necrolysis with retiform purpura.
PMID: 32281097 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Basu P, Tong Y, Hinds BR, Schneider JA Tags: Br J Dermatol Source Type: research

What's in? What's out? Updating the British Society for Cutaneous Allergy Facial Series.
CONCLUSION: This audit has highlighted the significant variation in practice that exists amongst patch test centres, despite a recommended facial series. The BSCA facial series has been updated and now contains 24 allergens. Fifteen allergens remain, 11 allergens have been dropped and 9 new allergens have been added. PMID: 32282055 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Rolls S, Owen E, Bertram CG, Bourke JF, Buckley DA, Chowdhury MMU, Cooper SM, Ghaffar SA, Green CM, Hughes TM, Johnston GA, Reckling CM, Thompson DA, Wakelin SH, Wilkinson M, Stone NM Tags: Br J Dermatol Source Type: research

Partner bereavement and risk of chronic urticaria, alopecia areata and vitiligo: cohort studies in the United Kingdom and Denmark.
In this study, we further investigated whether partner bereavement was associated with urticaria, alopecia areata, or vitiligo. PMID: 32282926 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Wong AYS, Kjaersgaard A, Frøslev T, Forbes HJ, Mansfield KE, Silverwood RJ, Sørensen HT, Smeeth L, Schmidt SAJ, Langan SM Tags: Br J Dermatol Source Type: research

The prognostic impact of the extent of ulceration in clinical stage I-II melanoma patients: A multicenter study of the Italian Melanoma Intergroup (IMI).
CONCLUSION: This study demonstrated that EU has an independent prognostic impact in PCM and should be recorded as a required element in pathology reports. PMID: 32282932 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Portelli F, Galli F, Cattaneo L, Cossa M, De Giorgi V, Forte G, Fraternali Orcioni G, Gianatti A, Indini A, Labianca A, Maurichi A, Merelli B, Montesco MC, Occelli M, Patuzzo R, Piazzalunga D, Pigozzo J, Quaglino P, Ribero S, Salvatori R, Saraggi D, Sena Tags: Br J Dermatol Source Type: research

Dermatologic adverse events associated with use of oral mechanistic target of rapamycin inhibitors in a cohort of individuals with tuberous sclerosis complex.
Abstract Systemic inhibitors of mechanistic target of rapamycin (mTOR) have antiproliferative, antiangiogenic, and immunosuppressive properties. In dermatology, they are effective for managing certain vascular anomalies and genodermatoses, notably tuberous sclerosis complex (TSC).1 Compared to cancer patients or transplant recipients, TSC patients are prescribed mTOR inhibitors at lower doses and their treatment regimens are less likely to include other drugs that may induce similar side effects. PMID: 32282933 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Pithadia DJ, Treichel AM, Jones AM, Julien-Williams P, Machado T, Moss J, Darling TN Tags: Br J Dermatol Source Type: research

Intervention Study to Evaluate the Importance of Information Given to Patients with Contact Allergy. A randomized, investigator-blinded clinical trial.
CONCLUSION: The performed intervention did not significantly affect the participants' ability to remember their contact allergy. To achieve better knowledge and changes in lifestyle, efforts to inform should concentrate on individuals with several positive patch test reactions, those with particular allergens, individuals over 60 years of age, and-concerning changes in lifestyle-males. PMID: 32282934 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Dizdarevic A, Troensegaard W, Uldahl A, Bergendorff O, Siemund I, Svensson Å, Sonesson A Tags: Br J Dermatol Source Type: research

Identification of a founder mutation in KRT14 associated with Naegeli-Franceschetti-Jadassohn-syndrome.
z RC Abstract Naegeli-Franceschetti-Jadassohn syndrome (NFJS; Mendelian Inheritance in Man (MIM) 161000) is a rare, autosomal-dominant ectodermal dysplasia.1 Affected individuals present with a heterogenous spectrum of ectodermal abnormalities. The most distinctive features are absent dermatoglyphics, reticulate hyperpigmentation of the skin, palmoplantar keratoderma, and decreased sweating. Other features may include abnormalities of the teeth, hair, nails, and skin. PMID: 32282935 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Ralser DJ, Kumar S, Borisov O, Sarig O, Richard G, Wolf S, Krawitz PM, Sprecher E, Kreiß M, Betz RC Tags: Br J Dermatol Source Type: research

Molecular subtype, biological sex and age shape melanoma tumour evolution.
CONCLUSIONS: These data indicate the contribution of environmental damage to melanoma likely extends beyond genetic damage to affect cell division. Sex and age determine the final mutational composition of melanoma. PMID: 32282938 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Lotz M, Budden T, Furney SJ, Virós A Tags: Br J Dermatol Source Type: research

Novel nicastrin mutation in hidradenitis suppurativa-Dowling Degos disease clinical phenotype: more than just clinical overlap?
Abstract In familial hidradenitis suppurativa (HS), mutations in the genes encoding three subunits of the -secretase complex, PSEN1, PSENEN and NCSTN, have pointed to an impaired NOTCH signalling as a pathogenic disease mechanism.1 Dowling Degos Disease (DDD; MIM 179850, 615327, and 615696)-a rare reticulated pigmentary disorder- has also been associated with a deficient NOTCH signalling and patients with mutations in PSENEN suffering from both disorders seem to confirm a potential link between two apparently different conditions. PMID: 32282940 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 12, 2020 Category: Dermatology Authors: Garcovich S, Tricarico PM, Meddour CN, Giovanardi G, Peris K, Crovella S, Boniotto M Tags: Br J Dermatol Source Type: research

Allergic contact dermatitis to non-methacrylate nail allergens in the UK.
Abstract The soaring demand for acrylic nails has resulted in a rapid increase in the frequency of allergic contact dermatitis (ACD) to (meth)acrylates1,2 . However, traditional nail varnish remains widely used. Nail varnish is a mixture of film formers and include nitrocellulose, adipic acid/neopentyl glycol/trimellitic anhydride copolymer (AA), and phthalic anhydride/trimellitic anhydride/glycols copolymer (PA). PMID: 32275769 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 9, 2020 Category: Dermatology Authors: Eleftheriadou V, Roche L, Bourke JF, Buckley DA, Orton DI, Stone NM, Wilkinson SM, Thompson DA, Johnston GA Tags: Br J Dermatol Source Type: research

Adenopathy and extensive skin patch overlying a plasmacytoma (AESOP) syndrome: erythrocyanotic vascular patches associated with an underlying rib plasmacytoma.
PMID: 32270486 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 8, 2020 Category: Dermatology Authors: Afra TP, Namitha R, Khader A, Bishnoi A, Shahul Hameed DK, Razmi T M Tags: Br J Dermatol Source Type: research

A mosaic variant in MAP2K1 is associated with giant naevus-spilus type congenital melanocytic naevus and melanoma development.
Abstract Giant congenital melanocytic naevi (CMN) arise primarily due to postzygotic mutations in NRAS, and are of clinical importance due to their increased risk of malignant transformation.1 A subtype of large CMN, termed naevus spilus (NS)-type CMN, is identified by the presence of a patch which may have café-au-lait pigmentation and superimposed macular or papular lesions, which are demonstrably melanocytic naevi on histology. PMID: 32271937 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 8, 2020 Category: Dermatology Authors: Muthiah S, Polubothu S, Husain A, Oliphant T, Kinsler VA, Rajan N Tags: Br J Dermatol Source Type: research

New effects of caffeine on CRH-induced stress along the intrafollicular classical HPA-axis (CRH-R1/2, IP3 -R, ACTH, MC-R2) and the neurogenic non-HPA-axis (substance P, p75NTR and TrkA) in ex vivo human male androgenetic scalp hair follicles.
Abstract Human hair is highly responsive to stress, and human scalp hair follicles (HFs) contain a peripheral neuro-endocrine equivalent of the systemic hypothalamic-pituitary-adrenal (HPA) stress axis. Androgenetic alopecia (AGA) is supposed to be aggravated by stress. We used the HPA axis triggering corticotropin-releasing hormone (CRH) to induce a stress response in human ex vivo male AGA HFs. Furthermore, since caffeine is known to reverse testosterone-mediated hair growth inhibition in the same hair organ culture model, we investigated whether caffeine would antagonize CRH-mediated stress in these HFs. HFs fr...
Source: The British Journal of Dermatology - April 8, 2020 Category: Dermatology Authors: Fischer TW, Bergmann A, Kruse N, Kleszczynski K, Skobowiat C, Slominski AT, Paus R Tags: Br J Dermatol Source Type: research

The use of tissue-engineered skin to demonstrate the negative effect of CXCL5 on epidermal UV radiation-induced CPD repair efficiency.
CONCLUSIONS: This work outlines the impact of the secreted dermal components on epidermal UVR-induced DNA damage repair and shed light on a novel role of CXCL5 in CPD repair. PMID: 32271940 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 8, 2020 Category: Dermatology Authors: Dorr MM, Guignard R, Auger FA, Rochette PJ Tags: Br J Dermatol Source Type: research

Adverse Skin Reactions Among Healthcare Workers During the Coronavirus Disease 2019 Outbreak: A Survey in Wuhan and Its Surrounding Regions.
Abstract During the outbreak of coronavirus disease 2019 (COVID-19), healthcare workers (HCWs) caring for COVID-19 patient have to wear personal protective equipment (PPE) and are therefore susceptible to PPE-related adverse skin reactions. However, little is known about the prevalence and characteristics of these adverse skin reactions and their associated risk factors. PMID: 32255197 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 6, 2020 Category: Dermatology Authors: Lin P, Zhu S, Huang Y, Li L, Tao J, Lei T, Song J, Liu D, Chen L, Shi Y, Jiang S, Liu Q, Xie J, Chen H, Duan Y, Xia Y, Zhou Y, Mei Y, Zhou X, Wu J, Fang M, Meng Z, Li H Tags: Br J Dermatol Source Type: research

The patient knows best: a new self-reported outcome measure for systemic sclerosis.
PMID: 32253751 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 5, 2020 Category: Dermatology Authors: Clark KEN, Denton CP Tags: Br J Dermatol Source Type: research

Drawstring papules in an Indian woman.
PMID: 32253758 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 5, 2020 Category: Dermatology Authors: Rajan MB, Budania A, Vishwajeet V Tags: Br J Dermatol Source Type: research

Cash is king: the balance of costs and effectiveness of treatments for actinic keratosis.
PMID: 32249410 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 4, 2020 Category: Dermatology Authors: Steeb T, Heppt MV, Berking C Tags: Br J Dermatol Source Type: research

Magnolol induces adipogenic differentiation in human skin.
Abstract The skin adipose tissue participates in energy storage, thermogenesis, endocrine secretion, fibrosis and scarring, and innate immune defense.1 Furthermore, the facial subcutaneous fat is important for skin aging such as elasticity and wrinkle formation.2,3 The subcutaneous layer as well as epidermal-dermal layer is modified with age through changes in its thickness, preadipocytes' differentiation, and size of adipocytes.4 It has been established that the age-dependent changes of fat layer are associated with our health, body shape and skin condition including metabolic diseases, obesity, and facial aging....
Source: The British Journal of Dermatology - April 4, 2020 Category: Dermatology Authors: Kim MS, Lee S, Park SB, Kim KY, Kim Y, Kang HY, Park SG, Kang NG Tags: Br J Dermatol Source Type: research

Stratifying clinical response to adjuvant platelet-rich plasma in androgenetic alopecia patients.
The objective of this study is to determine if AGA patient response to adjuvant PRP can be stratified based on quantitative hair counts after two treatment sessions. PMID: 32248528 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 4, 2020 Category: Dermatology Authors: Juhasz MLW, Sukhdeo K, Lo Sicco K, Shapiro J Tags: Br J Dermatol Source Type: research

Revolutionizing Atopic Dermatitis, 5 April 2020.
Authors: PMID: 32242919 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 2, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

15th Medical Dermatology Meeting, Royal College of Physicians, London, 9 January 2020.
Authors: PMID: 32236944 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 31, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

BJD Reviewers January 2019 - December 2019.
Authors: PMID: 32236946 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 31, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

It's the worry that got him in the end: the importance in treating melanoma holistically and dealing with fear of recurrence.
PMID: 32236948 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 31, 2020 Category: Dermatology Authors: Thompson AR, Cockayne S Tags: Br J Dermatol Source Type: research

Skin cancer screening: it's a matter of time.
PMID: 32237075 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 31, 2020 Category: Dermatology Authors: Ferris LK Tags: Br J Dermatol Source Type: research

Gene-environment interactions and melanoma risk.
PMID: 32239507 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 31, 2020 Category: Dermatology Authors: Cust AE Tags: Br J Dermatol Source Type: research

Paraneoplastic neutrophilic leukemoid reaction in a melanoma patient: association between tumour volume and leukocytosis.
We report the case of a PNLR that occurred during a metastatic melanoma and for which we retrospectively studied the relationship between PMNs count, tumour mass, serum LDH and G-CSF levels. PMID: 32232827 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 29, 2020 Category: Dermatology Authors: Fredeau L, Bohelay G, Shourick J, Piver D, Guyot A, -H Schlageter M, Caux F, Maubec E Tags: Br J Dermatol Source Type: research

Upregulated E3 ligase Trim21 in psoriatic epidermis ubiquitylates NF- κB p65 subunit and promotes inflammation in keratinocytes.
CONCLUSIONS: Our study confirms that upregulated Trim21 in psoriatic epidermis ubiquitylates p65 and activates the NF-κB pathway, which promotes keratinocyte inflammation. Hence, Trim21 represents a potential target for psoriasis treatment. PMID: 32232831 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 29, 2020 Category: Dermatology Authors: Yang L, Zhang T, Zhang C, Xiao C, Bai X, Wang G Tags: Br J Dermatol Source Type: research

Hand dermatitis in nurses: is promotion of protective behaviour ineffective?
PMID: 32232839 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 29, 2020 Category: Dermatology Authors: Brans R Tags: Br J Dermatol Source Type: research

Persistence of partner-assisted skin self-examination supported by "being in this together": a randomized trial.
Persistence of partner-assisted skin self-examination supported by "being in this together": a randomized trial. Br J Dermatol. 2020 Mar 28;: Authors: Robinson JK, Abou-El-Seoud D, Reavy R, Turrisi R, Mallett KA Abstract Since approximately 12% of melanoma survivors will develop another melanoma, skin self-examination (SSE) is relevant.1,2 Structured SSE training with a partner may overcome challenges including a) motivation to undertake SSE; b) competence to recognize concerning lesions, and c) difficulty with long-term maintenance (≥1 year).3,4 Partner-assisted SSE and subsequent clinic...
Source: The British Journal of Dermatology - March 27, 2020 Category: Dermatology Authors: Robinson JK, Abou-El-Seoud D, Reavy R, Turrisi R, Mallett KA Tags: Br J Dermatol Source Type: research

Habitual scratching amplifies and perpetuates atopic dermatitis.
lsh S Abstract We were fascinated and heartened to read this very helpful commentary1 on the study by Redhu et al2 who describe some precise physico-biological pathways that link skin barrier disruption to itch in atopic dermatitis (AD). This may well explain how curtailing scratching in AD with the simple behavioural technique of habit reversal can so dramatically improve the condition3. It is important to note that scratching in AD over time often becomes not only a response to itch, but also to both habit and mental state. PMID: 32222068 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 27, 2020 Category: Dermatology Authors: Staughton RCD, Bridgett CK, Norén P, Goulding JMR, Affleck A, Walsh S Tags: Br J Dermatol Source Type: research

Risk of Hospitalisation and Death due to Infection in People with Psoriasis: a Population-based Cohort Study using the Clinical Practice Research Datalink.
CONCLUSIONS: Psoriasis is associated with a small increase in the risk of serious infection. Further research is needed to understand how psoriasis predisposes to a higher risk of infection. PMID: 32222069 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 27, 2020 Category: Dermatology Authors: Yiu ZZN, Parisi R, Lunt M, Warren RB, Griffiths CEM, Langan SM, Ashcroft DM Tags: Br J Dermatol Source Type: research

Homeless status and associations with treatment disparities for common skin conditions.
Abstract Over 500,000 people experience homelessness in the United States on any given night.1 Skin disease is prevalent in homeless individuals, and increased morbidity has been attributed to environmental exposures, lack of resource access, and inconsistent healthcare.1,2 In this case-control study, we identify differences in dermatologists' management of common conditions in homeless relative to non-homeless patients that may contribute to healthcare disparities in the homeless. PMID: 32222073 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 27, 2020 Category: Dermatology Authors: Truong A, Secrest AM, Fino NF, Laggis CW, Lewis BKH Tags: Br J Dermatol Source Type: research

Ingenol mebutate 0.015% gel is safe for short-term treatment of actinic keratoses on the face in solid organ transplant recipients.
Abstract Immunosuppressed solid organ transplant recipients (SOTR) have a high burden of AK, but have been excluded from clinical trials of ingenol mebutate 0.015% gel. This leaves dermatologists and transplant teams to extrapolate safety data from immunocompetent patients or from two case reports of use in SOTR. This single-arm, open-label investigator-initiated study investigated the safety and tolerability of topical ingenol mebutate 0.015% gel in SOTR. PMID: 32221965 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 26, 2020 Category: Dermatology Authors: Crow LD, Yuan JT, Aroyan CS, Twigg AR, Singer JP, Roll GR, Lazar AA, Arron ST Tags: Br J Dermatol Source Type: research

Modalities of use of oral propranolol in proliferative infantile hemangiomas: an international survey among practitioners.
Abstract Infantile hemangiomas (IHs) are common benign vascular tumours in infants (estimated prevalence 5% to 10%).1 Oral propranolol is currently the first-line treatment for complicated proliferative IHs.2 It is approved by the US Food and Drug Administration and the European Medicines Agency for treating complicated IHs, but questions remain regarding the optimal modalities of use.3 We conducted an international survey to assess practices in prescribing oral propranolol for IHs among practitioners dealing with IHs worldwide. PMID: 32221977 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 26, 2020 Category: Dermatology Authors: Robert J, Tavernier E, Boccara O, Mashiah J, Mazereeuw-Hautier J, Maruani A Tags: Br J Dermatol Source Type: research

Frontal Fibrosing Alopecia shows robust Th1 and JAK3 skewing.
Abstract BACKGROUND: Frontal Fibrosing Alopecia (FFA) is a scarring alopecia with unclear pathogenesis and a progressive course. The disease has a major impact on patients' quality of life, lacking effective treatments to halt disease progression. METHODS: We profiled lesional and non-lesional scalp biopsies collected in 2017 from FFA patients (n=12) in comparison to scalp biopsies from alopecia areata (AA) (n=8) and control (n=8) individuals to evaluate gene and protein expression including the primary outcome (CXCL9). We determined significant differences between biomarkers by a two-sided Student's t-test a...
Source: The British Journal of Dermatology - March 24, 2020 Category: Dermatology Authors: Del Duca E, Ruano Ruiz J, Pavel AB, Dutt Sanyal R, Song T, Gay-Mimbrera J, Zhang N, Estrada YD, Peng X, Renert-Yuval Y, Phelps RG, Paus R, Krueger JG, Guttman-Yassky E Tags: Br J Dermatol Source Type: research

Lichen planopilaris and frontal fibrosing alopecia: branches from the same tree bear different fruits.
PMID: 32196647 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 19, 2020 Category: Dermatology Authors: Kinoshita-Ise M Tags: Br J Dermatol Source Type: research

No association between whole-body UVA1 phototherapy and skin cancers in humans: a cancer registry linkage study.
Abstract Ultraviolet A1 (UVA1) phototherapy was first developed in the 1980s.1 Its use started in the UK in Dundee in 1996.2 It is not available in most centres despite being useful for some of the sclerosing/fibrosing conditions and granulomatous conditions. Where available, for some individuals, it can be very helpful for other indications such as atopic eczema.3 A concern is that sufficient exposures might increase the risk of skin cancer.4 Itt has been shown to produce cyclobutane-pyrimidine dimers in humans,5 and so has the potential to be carcinogenic. PMID: 32198750 [PubMed - as supplied by publisher] ...
Source: The British Journal of Dermatology - March 19, 2020 Category: Dermatology Authors: Bedair K, Elhadad A, Hamad S, Ferguson J, Donnan P, Dawe RS Tags: Br J Dermatol Source Type: research

The efficacy of eribulin mesylate for patients with cutaneous angiosarcoma previously treated with taxane: a multi-center, prospective, observational study.
Abstract BACKGROUND: Taxanes are the current first-line treatment for advanced cutaneous angiosarcoma (CAS) for patients who considered difficult to treat with doxorubicin due to high age or comorbidity. However, no effective second-line therapy for such patients has been established. METHODS: We designed a single-arm, prospective observational study of eribulin mesylate (ERB) administered at a dose of 1.4mg/m2 on days 1 and 8 in a 21-day cycle. Advanced CAS patients previously treated with taxane scheduled for ERB use were enrolled. The primary endpoint was overall survival (OS) and the secondary endpoi...
Source: The British Journal of Dermatology - March 19, 2020 Category: Dermatology Authors: Fujisawa Y, Fujimura T, Matsushita S, Yamamoto Y, Uchi H, Otsuka A, Funakoshi T, Miyagi T, Hata H, Gosho M, Kambayashi Y, Aoki M, Yanagi T, Ohira A, Nakamura Y, Maeda T, Yoshino K Tags: Br J Dermatol Source Type: research