Basement membrane zone IgE deposition is associated with bullous pemphigoid disease severity and treatment results.
CONCLUSION: IgE deposition in the BMZ is associated with higher E/B BPDAI scores and longer treatment periods. We conclude that IgE binding in the BMZ may contribute to BP pathogenesis by promoting blister formation. This article is protected by copyright. All rights reserved. PMID: 31330562 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 22, 2019 Category: Dermatology Authors: Kamata A, Kurihara Y, Funakoshi T, Takahashi H, Kuroda K, Hachiya T, Amagai M, Yamagami J Tags: Br J Dermatol Source Type: research

Anticomplement therapy in bullous pemphigoid.
PMID: 31328264 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 21, 2019 Category: Dermatology Authors: Hashimoto T, Kanazawa N, Inoue N Tags: Br J Dermatol Source Type: research

Complete Skin Clearance and PASI response rates in clinical practice- Predictors, Health Related Quality of Life improvements and implications for treatment goals.
Abstract BACKGROUND: PASI90 is suggested to be the new standard endpoint RCTs of biologics for psoriasis, whereas treatment guidelines often still refer to PASI75. OBJECTIVES: To analyse in a real-world setting: Firstly, what factors are associated with higher levels of treatment response to biologics. Secondly, the Health-Related Quality of Life gains associated with different response levels in clinical practice. METHODS: Biologically-naïve patients with PASI, DLQI and EQ-5D outcomes before (maximum 6 months) and after (3-12 months) switch to biologics during registration in the Swedish Register f...
Source: The British Journal of Dermatology - July 20, 2019 Category: Dermatology Authors: Norlin JM, Nilsson K, Persson U, Schmitt-Egenolf M Tags: Br J Dermatol Source Type: research

Dupilumab improved atypical fibrotic skin plaques in atopic dermatitis.
This article is protected by copyright. All rights reserved. PMID: 31325158 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 19, 2019 Category: Dermatology Authors: Nakashima C, Ishida Y, Kaku Y, Epstein EH, Otsuka A, Kabashima K Tags: Br J Dermatol Source Type: research

Autoimmune radiculoplexus neuropathy under adjuvant nivolumab treatment of a female melanoma patient.
This article is protected by copyright. All rights reserved. PMID: 31325163 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 19, 2019 Category: Dermatology Authors: Gambichler T, Susok L, Fels M, Schneider-Gold C, Hof Zum Berge F, Stockfleth E, Ayzenberg I Tags: Br J Dermatol Source Type: research

Morphea induced by treatment with Interferon β-1α.
This article is protected by copyright. All rights reserved. PMID: 31323114 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 19, 2019 Category: Dermatology Authors: Peterson E, Steuer A, Franco L, Nolan MA, Lo Sicco K, Franks AG Tags: Br J Dermatol Source Type: research

Trends in mortality rates for Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN): experience of a single center in France between 1997 and 2017.
Abstract Epidermal necrolysis (EN), the spectrum including Stevens-Johnson syndrome (SJS, detached-detachable body surface area [BSA]
Source: The British Journal of Dermatology - July 19, 2019 Category: Dermatology Authors: Bettuzzi T, Penso L, de Prost N, Hemery F, Hua C, Colin A, Mekontso-Dessap A, Fardet L, Chosidow O, Wolkenstein P, Sbidian E, Ingen-Housz-Oro S Tags: Br J Dermatol Source Type: research

Ex vivo human models of hidradenitis suppurativa/acne inversa for laboratory research and drug screening.
PMID: 31321767 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 18, 2019 Category: Dermatology Authors: Zouboulis CC Tags: Br J Dermatol Source Type: research

How do you determine the optimal biologic treatment for psoriasis?
PMID: 31318044 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 18, 2019 Category: Dermatology Authors: Gardner R, Burden AD Tags: Br J Dermatol Source Type: research

Why use an allergy-based quality of life measure in childhood atopic eczema?
PMID: 31317542 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 17, 2019 Category: Dermatology Authors: Manolache L, Finlay AY Tags: Br J Dermatol Source Type: research

Choice of topical prodrug in daylight photodynamic therapy for actinic keratoses.
PMID: 31314130 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 17, 2019 Category: Dermatology Authors: Dawe RS Tags: Br J Dermatol Source Type: research

Long noncoding RNA single-nucleotide polymorphisms: a new cause of genetic susceptibility to autoimmune blistering disease.
PMID: 31314134 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 17, 2019 Category: Dermatology Authors: Amber KT Tags: Br J Dermatol Source Type: research

Deciphering the molecular morphology of the human hair cycle: Wnt signalling during the telogen-anagen transformation.
CONCLUSION: We provide the first evidence that key changes in Wnt signalling that drive murine anagen-induction also occur in human scalp HFs, yet with notable differences. This provides a rational basis for Wnt-targeting therapeutic interventions to manipulate human hair growth disorders. This article is protected by copyright. All rights reserved. PMID: 31314901 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 17, 2019 Category: Dermatology Authors: Hawkshaw NJ, Hardman JA, Alam M, Jimenez F, Paus R Tags: Br J Dermatol Source Type: research

CFTRgene variants:A predisposition factor to aquagenic palmoplantar keratoderma.
This article is protected by copyright. All rights reserved. PMID: 31310009 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 16, 2019 Category: Dermatology Authors: Raynal C, Girodon E, Audrezet MP, Cabet F, Pagin A, Reboul MP, Dufernez F, Fergelot P, Bergougnoux A, Fanen P, Ferec C, Bienvenu T Tags: Br J Dermatol Source Type: research

Image Gallery: A reticular variant of actinic granuloma.
PMID: 31309535 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 15, 2019 Category: Dermatology Authors: Ma DL, Qian YT, Liu JW, Liu W Tags: Br J Dermatol Source Type: research

Grading immunohistochemical markers p16INK4a and HPV E4 identifies productive and transforming lesions caused by low- and high-risk HPV within high-grade anal squamous intraepithelial lesions.
CONCLUSIONS: Combined p16/E4 IHC identifies productive and non-productive HSIL associated with hrHPV within the group of HSIL defined by the Lower Anogenital Squamous Terminology recommendations. This opens the possibility of investigating selective treatment of hrHPV-caused advanced transforming HSIL and a "wait and see" policy for productive HSIL. PMID: 31302935 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 14, 2019 Category: Dermatology Authors: Leeman A, Jenkins D, Marra E, van Zummeren M, Pirog EC, van de Sandt MM, van Eeden A, Schim van der Loeff MF, Doorbar J, de Vries HJC, van Kemenade FJ, Meijer CJLM, Quint WGV Tags: Br J Dermatol Source Type: research

Matching burden of skin diseases, demand for dermatological consultations and clinical research activity: results from three national studies.
This article is protected by copyright. All rights reserved. PMID: 31301228 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 13, 2019 Category: Dermatology Authors: Gutiérrez-González E, Descalzo-Gallego MA, Molina-Leyva A, Kueder-Pajares T, Buendía-Eisman A, García-Doval I Tags: Br J Dermatol Source Type: research

A case of bullous pemphigoid with mucosal involvement serologically positive only for anti-BP230 autoantibodies.
This article is protected by copyright. All rights reserved. PMID: 31301230 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 13, 2019 Category: Dermatology Authors: Taki T, Takeichi T, Kono M, Sugiura K, Sugimura Y, Ishii N, Hashimoto T, Akiyama M Tags: Br J Dermatol Source Type: research

Oral antibiotics in acne: a retrospective single centre analysis of current prescribing in primary care and it's alignment with the national antibiotic quality premium.
This article is protected by copyright. All rights reserved. PMID: 31301232 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 13, 2019 Category: Dermatology Authors: Whitehouse H, Solman L, Eady EA, Layton AM Tags: Br J Dermatol Source Type: research

Detailed hair shaft analysis in an adult man with delayed onset Chediak-Higashi syndrome.
This article is protected by copyright. All rights reserved. PMID: 31301233 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 13, 2019 Category: Dermatology Authors: Veraitch O, Allison L, Vizcay-Barrena G, Fleck RA, Price A, Fenton DA, McGrath JA, Stefanato CM Tags: Br J Dermatol Source Type: research

Efficacy of topical EGF cream for patients with EGFR inhibitor-induced acneiform eruption: A randomized controlled trial.
This article is protected by copyright. All rights reserved. PMID: 31301244 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 13, 2019 Category: Dermatology Authors: Lee JH, Ju HJ, Kwon HS, Jung HM, Kim GM, Bae JM, An HJ Tags: Br J Dermatol Source Type: research

Actinic Keratosis Clinical Course Correlates with Underlying Molecular Mechanisms.
Abstract BACKGROUND: Actinic keratoses (AKs) are common premalignant skin lesions triggered by excessive UV exposure. The majority of AKs regress or persist, but some progress to squamous cell carcinomas. The biomarkers associated with their persistence, progression and regression have not been characterized. OBJECTIVE: We performed skin biopsies in patients with extensive actinic damage to identify biomarkers that correlate with clinical progression and regression of AKs. METHODS: This was an observational study of a cohort of patients with extensive actinic damage. AKs were mapped on a clear plastic te...
Source: The British Journal of Dermatology - July 12, 2019 Category: Dermatology Authors: Bakshi A, Shafi R, Nelson J, Cantrell WC, Subhadarshani S, Andea A, Athar M, Elmets CA Tags: Br J Dermatol Source Type: research

Image Gallery: Black hairy tongue in a patient receiving enteral feeding.
PMID: 31297789 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 11, 2019 Category: Dermatology Authors: Wang X, Yang S, Wang Y Tags: Br J Dermatol Source Type: research

Reproductive factors and risk of melanoma: still unresolved.
PMID: 31290145 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 9, 2019 Category: Dermatology Authors: Olsen CM Tags: Br J Dermatol Source Type: research

Image gallery: Fluoroscopy-induced radiation dermatitis.
PMID: 31287153 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 9, 2019 Category: Dermatology Authors: Huang TH, Hu SC Tags: Br J Dermatol Source Type: research

A diagnostic algorithm for enhanced detection of mosaic tuberous sclerosis complex in adults.
This article is protected by copyright. All rights reserved. PMID: 31287558 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 9, 2019 Category: Dermatology Authors: Treichel AM, Kwiatkowski DJ, Moss J, Darling TN Tags: Br J Dermatol Source Type: research

Psoriasis treat to target: defining outcomes in psoriasis using data from a real world, population-based cohort study (the British Association of Dermatologists Biologics and Immunomodulators Register, BADBIR).
Abstract BACKGROUND: The 'treat to target' paradigm improves outcomes and reduces costs in chronic disease management but is not yet established in psoriasis. OBJECTIVE: To identify treatment targets in psoriasis using the common measures of disease activity: Psoriasis Area and Severity Index (PASI) and Physician Global Assessment (PGA). METHODS: Data from a multicentre longitudinal UK cohort of psoriasis patients receiving systemic/biologic therapies (British Association of Dermatologists Biologics and Immunomodulators Register) were used to identify absolute PASI thresholds for 90% (PASI 90) and 75% (P...
Source: The British Journal of Dermatology - July 8, 2019 Category: Dermatology Authors: Mahil SK, Wilson N, Dand N, Reynolds NJ, Griffiths CEM, Emsley R, Marsden A, Evans I, Warren RB, Stocken D, Barker JN, Burden AD, Smith CH, BADBIR study group and the PSORT consortium Tags: Br J Dermatol Source Type: research

The boiling brain.
PMID: 31286473 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 8, 2019 Category: Dermatology Authors: Jemec GBE Tags: Br J Dermatol Source Type: research

Sustained Efficacy of Secukinumab in Subjects with Moderate-to-Severe Palmoplantar Psoriasis: 2 ·5-Year Results from GESTURE, a Randomized, Double-blind, Placebo-controlled Trial.
CONCLUSIONS: GESTURE, the largest and longest duration randomized controlled trial in ppPsO to date, revealed that secukinumab provides a strong and sustained response over 2·5 years in challenging-to-treat ppPsO. This article is protected by copyright. All rights reserved. PMID: 31286480 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 8, 2019 Category: Dermatology Authors: Gottlieb AB, Kubanov A, van Doorn M, Sullivan J, Papp KA, You R, Regnault P, Frueh JA Tags: Br J Dermatol Source Type: research

Leprosy in French Guiana 2007-2014: a re-emerging public health problem.
This article is protected by copyright. All rights reserved. PMID: 31286485 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 8, 2019 Category: Dermatology Authors: Graille J, Blaizot R, Darrigade AS, Sainte-Marie D, Nacher M, Schaub R, Couppié P Tags: Br J Dermatol Source Type: research

Hidradenitis Suppurativa Area and Severity Index (HASI): a pilot study to develop a novel instrument to measure the physical signs of hidradenitis suppurativa.
This article is protected by copyright. All rights reserved. PMID: 31286486 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 8, 2019 Category: Dermatology Authors: Goldfarb N, Ingram JR, Jemec GBE, Naik HB, Piguet V, Hyde MJ, Freese R, Lowes MA, Alavi A Tags: Br J Dermatol Source Type: research

Severity staging of hidradenitis suppurativa: is Hurley classification the answer?
PMID: 31281960 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 7, 2019 Category: Dermatology Authors: Thorlacius L Tags: Br J Dermatol Source Type: research

Where does psoriasis hold out in the era of biologics?
e;n I PMID: 31281962 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 7, 2019 Category: Dermatology Authors: Belinchón I Tags: Br J Dermatol Source Type: research

Image Gallery: Clofazimine-induced hyperpigmentation of leprosy plaques.
PMID: 31281972 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 7, 2019 Category: Dermatology Authors: Bishnoi A, Chatterjee D, Narang T, Dogra S Tags: Br J Dermatol Source Type: research

Translational research in disorders of DNA repair: the challenges in the application of therapeutic discoveries to the treatment of human disease.
PMID: 31281978 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 7, 2019 Category: Dermatology Authors: Fassihi H Tags: Br J Dermatol Source Type: research

Skin fragility caused by biallelic KRT10 mutations: an intriguing form of self-improving epidermolytic ichthyosis.
This article is protected by copyright. All rights reserved. PMID: 31278741 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 6, 2019 Category: Dermatology Authors: Frommherz L, Küsel J, Zimmer A, Fischer J, Has C Tags: Br J Dermatol Source Type: research

Challenges in the diagnosis of primary cutaneous CD30+ anaplastic large-cell lymphoma.
This article is protected by copyright. All rights reserved. PMID: 31278742 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 6, 2019 Category: Dermatology Authors: Dobos G, Battistella M, Jouenne F, Mourah S, Vignon-Pennamen MD, Ram-Wolff C, Herms F, Dauendorffer JN, Rivet J, Cayuela JM, Bouaziz JD, Brice P, Lebbé C, Bagot M, de Masson A Tags: Br J Dermatol Source Type: research

Years Lost Due to Disability from Skin Diseases in China 1990-2017: Findings from the Global Burden of Disease Study 2017.
This study aimed to measure the burden of skin diseases in China. This article is protected by copyright. All rights reserved. PMID: 31278743 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 6, 2019 Category: Dermatology Authors: Dong W, An J, Geng P, Zeng X, Chen Y, Zhao Z, Zhou M Tags: Br J Dermatol Source Type: research

Quality of life and psychological impact in the photodermatoses: a systematic review.
CONCLUSIONS: Several tools have been used to assess QoL in the photodermatoses, and confirm substantial impact on QoL. Development of specific, validated QoL measures would address their unique impacts. Research delineating their psychological comorbidity is sparse and requires further exploration. This article is protected by copyright. All rights reserved. PMID: 31278744 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 6, 2019 Category: Dermatology Authors: Rutter KJ, Ashraf I, Cordingley L, Rhodes LE Tags: Br J Dermatol Source Type: research

Comparable Efficacy and Safety of Brodalumab in Obese and Non-Obese Patients With Psoriasis: Analysis of 2 Randomized Controlled Trials.
Abstract BACKGROUND: Obesity is associated with psoriasis and negatively affects response to therapy. OBJECTIVE: To evaluate efficacy and safety of brodalumab in non-obese vs obese patients with psoriasis. METHODS: In this post hoc analysis of the prospective, phase 3, multicentre, randomized, placebo- and active comparator-controlled AMAGINE-2 and AMAGINE-3 trials, patients were randomized to treatment with brodalumab 210 mg every 2 weeks, ustekinumab, or placebo for a 12-week induction phase. At week 12, patients who received brodalumab 210 mg Q2W continued brodalumab, those treated with ustekinumab co...
Source: The British Journal of Dermatology - July 5, 2019 Category: Dermatology Authors: Hsu S, Green LJ, Lebwohl MG, Wu JJ, Blauvelt A, Jacobson AA Tags: Br J Dermatol Source Type: research

Defining Lesional, Perilesional and Unaffected Skin in Hidradenitis Suppurativa: Proposed Recommendations for Clinical Trials and Translational Research Studies.
This article is protected by copyright. All rights reserved. PMID: 31269228 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 3, 2019 Category: Dermatology Authors: Frew JW, Navrazhina K, Byrd AS, Garg A, Ingram JR, Kirby JS, Lowes MA, Naik H, Piguet V, Prens EP Tags: Br J Dermatol Source Type: research

Generalized skin hyperpigmentation as the only manifestation of X-linked adrenoleukodystrophy.
This article is protected by copyright. All rights reserved. PMID: 31269232 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 3, 2019 Category: Dermatology Authors: Lee H, Ko JM, Lee SH Tags: Br J Dermatol Source Type: research

Image Gallery: Squamous cell carcinoma arising from chronic radiodermatitis.
PMID: 31264705 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 2, 2019 Category: Dermatology Authors: Liu JW, Liu W, Qian YT, Ma DL Tags: Br J Dermatol Source Type: research

Abstracts for the British Association of Dermatologists 99th Annual Meeting, Liverpool, U.K., 2-4 July 2019.
Authors: PMID: 31264203 [PubMed] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 1, 2019 Category: Dermatology Tags: Br J Dermatol Source Type: research

Mosaicism: time matters.
PMID: 31259383 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 1, 2019 Category: Dermatology Authors: Torrelo A Tags: Br J Dermatol Source Type: research

Do sunscreens block vitamin D production? A critical review by an international panel of experts.
PMID: 31259384 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 1, 2019 Category: Dermatology Authors: Bikle DD Tags: Br J Dermatol Source Type: research

Chronic tissue damage: a common pathomechanism of genodermatoses.
PMID: 31259385 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 1, 2019 Category: Dermatology Authors: Has C Tags: Br J Dermatol Source Type: research

Abstracts.
In conclusion, HS can negatively affect a person's work life and income earning, suggesting that better therapies are needed to help manage the disease symptoms and improve the lives of people with HS. PMID: 31259391 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 1, 2019 Category: Dermatology Authors: Tzellos T, Yang H, Mu F, Calimlim B, Signorovitch J Tags: Br J Dermatol Source Type: research

Anatomical location differences in sodium lauryl sulfate-induced irritation.
PMID: 31259392 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 1, 2019 Category: Dermatology Authors: Oosterhaven JAF Tags: Br J Dermatol Source Type: research

Immunological diagnostic methods in oral mucosal diseases.
PMID: 31259393 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 1, 2019 Category: Dermatology Authors: Hashimoto T, Nakahara H Tags: Br J Dermatol Source Type: research