Absence of Skin of Colour Images in Publications of COVID-19 Skin Manifestations.
Abstract There are now over 1 million confirmed cases of COVID-19 globally with more than 270,000 recorded deaths to date. COVID-19 has been shown to disproportionately impact people of colour both in the United Kingdom and in the United States where blacks make up 13.4% of the population but 30% of COVID-19 cases. Mounting evidence shows that COVID-19 impacts several organ systems, including the skin. PMID: 32471009 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 29, 2020 Category: Dermatology Authors: Lester JC, Jia JL, Zhang L, Okoye GA, Linos E Tags: Br J Dermatol Source Type: research

Outcome domains in Lichen Sclerosus.
Abstract Lichen Sclerosus (LS) is a chronic inflammatory dermatosis predominantly affecting the genitals. It can affect men, women and children. LS affecting female genitalia typically presents with itchy patches that impact on physical and psychosocial-sexual functioning1,2 . Symptoms in men include difficulty urinating due to urethral narrowing, difficulty in foreskin retraction due to scarring, and dyspareunia. Complications include loss of anatomy and malignant transformation. PMID: 32471015 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 29, 2020 Category: Dermatology Authors: Goodrum CA, Leighton PA, Simpson RC Tags: Br J Dermatol Source Type: research

Virtual melanoma checks during a pandemic.
Abstract Healthcare services internationally are experiencing unprecedented strain due to the COVID-19 pandemic. Governments mandate strict social distancing to reduce the spread of SARS-CoV-2 infection, and as a result, people are avoiding health services for less urgent issues. In this crisis, it is important that patients continue to receive preventive and surveillance care without compromising their safety or that of healthcare workers. PMID: 32471016 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 29, 2020 Category: Dermatology Authors: Janda M, Swetter SM, Horsham C, Soyer HP Tags: Br J Dermatol Source Type: research

Further evidence that chilblains are a cutaneous manifestation of COVID-19 infection.
Abstract A range of cutaneous conditions including chilblain-like lesions have been reported in patients with Coronavirus 2019 (COVID-19) due to severe acute respiratory Syndrome coronavirus 2 (SARS-Cov-2). Using clinical data and images, the authors of a recent nationwide Spanish survey identified 5 clinical patterns which were associated with different patient demographics, onset (timing), and prognosis. PMID: 32460349 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 27, 2020 Category: Dermatology Authors: Hughes M, Rogers S, Lepri G, Bruni C, Matucci-Cerinic M Tags: Br J Dermatol Source Type: research

Reliability and validity of the Vitiligo Signs of Activity Score.
PMID: 32458411 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 26, 2020 Category: Dermatology Authors: Eleftheriadou V Tags: Br J Dermatol Source Type: research

The value of ongoing surveillance on the prevalence of contact sensitization.
PMID: 32458421 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 26, 2020 Category: Dermatology Authors: Schuttelaar MLA Tags: Br J Dermatol Source Type: research

Is targeting circulating T blood cells a therapeutic option for vitiligo?
PMID: 32458433 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 26, 2020 Category: Dermatology Authors: Matos TR Tags: Br J Dermatol Source Type: research

Meta-analysis results do not reflect the real safety of biologics in psoriasis.
CONCLUSION: On excluding cases of worsening psoriasis, the risk of occurrence of SAEs is higher in the biological than in the placebo arm. Given the rare events, we could not highlight whether this higher risk of SAEs was related to AEs of special interest. Reporting of SAEs in clinical trials has to be changed to provide more transparency through the separate reporting of disease flares leading to hospital admission and other SAEs. PMID: 32446286 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 23, 2020 Category: Dermatology Authors: Afach S, Chaimani A, Evrenoglou T, Penso L, Brouste E, Sbidian É, Le Cleach L Tags: Br J Dermatol Source Type: research

Dimethyl fumarate modulates the Treg:Th17 cell axis in psoriasis patients.
CONCLUSIONS: DMF enhanced the ratio of Treg:Th17 cells both in psoriasis patients, multiple sclerosis patients and in vitro. Furthermore, our data suggest that this is at least in part as a result of the differential effects of DMF on Treg compared with T conventional cells. PMID: 32438447 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 21, 2020 Category: Dermatology Authors: Sulaimani J, Cluxton D, Clowry J, Petrasca A, Molloy OE, Moran B, Sweeney CM, Malara A, McNicholas N, McGuigan C, Kirby B, Fletcher JM Tags: Br J Dermatol Source Type: research

Average daily itch versus worst daily itch in chronic itch evaluation.
Abstract Chronic itch can be a debilitating medical condition with clinical characteristics and impact akin to chronic pain. Itch severity is subjective and clinicians depend on patient reported numerical ratings scales (NRS); most commonly 24-hour worst itch (WI-NRS) has been validated including large scale studies. WI-NRS does not attempt to take into account itch duration or the variability that is often experienced throughout the day and night by chronic itch patients. PMID: 32438472 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 21, 2020 Category: Dermatology Authors: Fourzali KM, Golpanian S, Chan YH, Yosipovitch G Tags: Br J Dermatol Source Type: research

Prevalence of hidradenitis suppurativa is one percent of the population of Wales using the Secure Anonymised Information Linkage (SAIL) Databank.
Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease with multiple inflammatory skin lesions ('boils') in flexural locations.1 Prevalence of HS remains controversial2,3 and the study aim was to search the Secure Anonymous Information Linkage (SAIL) Databank to identify diagnosed and undiagnosed HS cases in Wales, UK. PMID: 32433788 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 20, 2020 Category: Dermatology Authors: Ingram JR, Collins H, Atkinson MD, Brooks CJ Tags: Br J Dermatol Source Type: research

A Phase 2, randomized, double-blind, placebo-controlled, dose-ranging study to evaluate the efficacy and safety of VT-1161 oral tablets in the treatment of patients with distal and lateral subungual onychomycosis of the toenail.
Abstract BACKGROUND: Onychomycosis is a fungal disease that affects the fingernails and toenails and is predominantly caused by dermatophytes. VT-1161 is a novel inhibitor of fungal CYP51 through the inhibition of the lanosterol demethylase, and has demonstrated potent activity against T. rubrum and T. mentagrophytes. OBJECTIVE: To evaluate the safety and efficacy of four dosing regimens of orally-administered VT-1161 compared with placebo in patients with moderate to severe distal and lateral subungual onychomycosis of the toenail. METHOD: A Phase 2, randomized, double-blind, placebo-controlled, multice...
Source: The British Journal of Dermatology - May 18, 2020 Category: Dermatology Authors: Elewski B, Brand S, Degenhardt T, Curelop S, Pollack R, Schotzinger R, Tavakkol A Tags: Br J Dermatol Source Type: research

Fee-for-service and structural forces may drive racial disparities in US dermatology.
Abstract Despite controversy, fee-for-service (FFS) remains the predominant insurance model in the United States. Under FFS, physicians are incentivized to perform services based on negotiated rates by insurance companies. These agreed upon rates for reimbursements may indirectly drive overutilization, specifically of procedures. Dermatology is a unique field with procedures performed quickly in outpatient visits. As a result, FFS and current policies can add a conflict of interest that incentivizes dermatologists both to perform more procedures and to optimize payer mixes and populations. PMID: 32406519 [Pub...
Source: The British Journal of Dermatology - May 14, 2020 Category: Dermatology Authors: Wang LL, Adelekun A, Taylor SC, Lipoff JB Tags: Br J Dermatol Source Type: research

Discovery of heterozygous KRT10 alterations in MAUIE patients underlines the importance of regular skin cancer screening in ichthyosis with confetti-patients.
Abstract Ichthyosis with confetti (IWC) (OMIM#609165), also known as congenital reticular ichthyosiform erythroderma (CRIE), is an autosomal dominant genodermatosis with erythroderma on the entire body surface. Unique to IWC is the development of 100s and 1000s of pale spots resembling healthy skin. Almost 20% of the patients develop non-melanoma skin cancer (NMSC) in early adulthood for unknown reasons. In all the patients heterozygous variants in either keratin (KRT)10 or KRT1 have been found leading to a shifted reading-frame and translation of an aberrant carboxyl-terminus of the protein. PMID: 32407542 [...
Source: The British Journal of Dermatology - May 14, 2020 Category: Dermatology Authors: Burger B, Ghosh A, Ng CKY, Piscuoglio S, Spoerri I, Itin PH, Greer K, Elbaum D Tags: Br J Dermatol Source Type: research

Ifosfamide and etoposide in advanced-stage, relapsed or refractory primary cutaneous T-cell lymphomas.
son A Abstract Ifosfamide + etoposide (I+E) have been used to treat lymphomas, combined with platinum-based agents in Hodgkin disease or non-Hodgkin lymphomas including peripheral T-cell lymphomas. Monoclonal antibodies have induced long-term remissions in CTCL but are usually poorly effective in transformed disease. Allogeneic hematopoietic stem cell transplantation (alloHSCT) holds a potential for cure but relies on the existence of a pre-transplant CR which may require the use of chemotherapeutic regimens. PMID: 32407544 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 14, 2020 Category: Dermatology Authors: Dangien A, Ram-Wolff C, Brice P, Battistella M, Roelens M, Moins-Teisserenc H, de Latour RP, Mourah S, Bouaziz JD, Lebbé C, Bagot M, de Masson A Tags: Br J Dermatol Source Type: research

Longer duration of lower limb symptoms makes cellulitis diagnosis less likely in secondary care.
Abstract The 2017 Cellulitis Priority Setting Partnership prioritised research into diagnosis and treatment of cellulitis. Cellulitis diagnosis is based on history, examination and inflammatory markers. No validated diagnostic criteria or tools exist4 and up to 68% with suspected lower limb cellulitis (LLC) may not have the condition leading to unnecessary hospital admission and antibiotic treatment. PMID: 32407546 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 14, 2020 Category: Dermatology Authors: Mistry K, Levell NJ Tags: Br J Dermatol Source Type: research

Interrogation of safety and efficacy of home-use light-based devices.
Abstract We read with interest the short paper describing, and commend the authors on sharing their experience the continued use of phototherapy in COVID-19 affected Italy. Phototherapy is undoubtedly a long-established, relatively safe means of reducing the burden of inflammatory skin disease avoiding large doses of immunosuppression. Home phototherapy devices and services have a long-established use in many countries throughout the world, as described in previous issues of this journal. PMID: 32407551 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 14, 2020 Category: Dermatology Authors: Ali FR, Al-Niaimi F Tags: Br J Dermatol Source Type: research

Thrombotic occlusive vasculopathy in skin biopsy from a livedoid lesion of a COVID-19 patient.
acute;a B, Fraga J, Daudén-Tello E Abstract Some authors have reported the presence of cutaneous lesions related to new COronaVirus Disease 2019 (CoViD-19) caused by SARS-CoV-2, in up to 20.4% of the cases; however, these lesions are not well characterized either clinically or histopathologically.1 Recently, it has been highlighted the finding of congested and edematous blood vessels in the alveolar septum along with hyaline thrombi, and also in the heart, liver and kidney of autopsies of 3 patients deceased due to severe infection by SARS-CoV-2. PMID: 32407552 [PubMed - as supplied by publisher] (Sour...
Source: The British Journal of Dermatology - May 14, 2020 Category: Dermatology Authors: Llamas-Velasco M, Muñoz-Hernández P, Lázaro-González J, Reolid-Pérez A, Abad-Santamaría B, Fraga J, Daudén-Tello E Tags: Br J Dermatol Source Type: research

Acral Lentiginous Melanoma: Clinicopathologic Characteristics and Survival Outcomes in the United States National Cancer Database 2004 -2016.
Abstract Acral lentiginous melanoma (ALM) is one of four subtypes of cutaneous melanoma (CM) comprising of 2-3% of all melanomas in the United States. It occurs predominantly on the palms, soles, and nail beds. It is a common subtype found in people with darker skin types. Acral lentiginous melanomas are generally associated with a poor prognosis. Understanding of the demographics, outcomes, and treatment of this type of melanoma can be aided by studying a larger cancer registry. PMID: 32407556 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 14, 2020 Category: Dermatology Authors: Behbahani S, Malerba S, Samie FH Tags: Br J Dermatol Source Type: research

Detection of genetic tumour predisposition syndromes using electronic health records.
Abstract The restricted tumour repertoire of certain genetic skin tumour syndromes, such as CYLD cutaneous syndrome (CCS), is well recognised.1 Patients with CCS develop multiple benign cylindromas and spiradenomas, a presentation of skin appendageal tumours recognised to be exclusively associated with CYLD loss. Consequently, pathology coding records, which capture tumour level data, can be interrogated to detect patients who may have undiagnosed CCS based on the presentation of multiple CCS specific tumours over time. PMID: 32407560 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 14, 2020 Category: Dermatology Authors: Cook S, Wilson V, Ness J, Burn J, Husain A, Rajan N Tags: Br J Dermatol Source Type: research

Guselkumab versus secukinumab for the treatment of moderate-to-severe psoriasis: a critical appraisal.
Abstract The last two decades have seen a rapid growth of targeted biologic therapies for moderate-to-severe plaque psoriasis. While undoubtedly a boon for patients and their treating clinicians alike, the growing number of highly efficacious drug options can make treatment choice challenging. As such, head-to-head randomized controlled trials (RCTs) are necessary to compare the efficacy and safety of therapies to one another. While, to date, most head-to-head RCTs of biologic therapies for psoriasis have compared newer drugs (e.g., IL-17 or IL-23 inhibitors) to older ones (e.g., tumor necrosis factor or IL-12/23 ...
Source: The British Journal of Dermatology - May 14, 2020 Category: Dermatology Authors: Wan MT, Takeshita J Tags: Br J Dermatol Source Type: research

The effect of a dermato-oncologic training program on the diagnostic skills and quality of referrals for suspicious skin lesions by general practitioners.
Abstract BACKGROUND: The rising incidence rates of skin cancer (SC) lead to an enormous burden on healthcare systems. General practitioners (GPs) might play an important part in SC care, but research showed poor clinical recognition of SC, leading to a high rate of potentially unnecessary referrals. OBJECTIVES: The aim of this study was to evaluate if a dermato-oncologic training program (DOTP) for GPs improved their diagnostic skills and quality of referrals. METHODS: 83 (42,8%) out of 194 GPs in the Nijmegen area followed a DOTP on SC. Referrals from both a trained cohort (TC) and two cohorts of untrai...
Source: The British Journal of Dermatology - May 14, 2020 Category: Dermatology Authors: Marra E, van Rijsingen MCJ, Alkemade JAC, Groenewoud JMM, Hueskes KF, Nij Bijvank CHM, van de Laar FA, Lubeek SFK Tags: Br J Dermatol Source Type: research

Pemphigus foliaceus and sand fly bites: assessing the humoral immune response to the salivary proteins maxadilan and LJM11.
Abstract Roselino et al. (2001) reported the first link between salivary proteins from sand flies and pemphigus foliaceus (PF) pathogenesis on the basis that patients living in a Brazilian region where PF is endemic showed higher titers of IgG antibodies against maxadilan, one of the most immunogenic salivary proteins described in Lutzomyia longipalpis, as compared to healthy controls (HC). For another Brazilian focus, Qian et al. (2012) reported that antibodies against LJM11, another highly immunogenic salivary protein from Lu. longipalpis, cross-react with Desmoglein (Dsg) 1. PMID: 32407578 [PubMed - as sup...
Source: The British Journal of Dermatology - May 14, 2020 Category: Dermatology Authors: Vernal S, De Paula NA, Bollela VR, Lerner EA, Roselino AM Tags: Br J Dermatol Source Type: research

Altered hydroxymethylation in cutaneous squamous cell carcinoma and keratoacanthoma.
Abstract We studied formalin-fixed and paraffin-embedded tissue of patients with cSCC, AK, and KA. We included only lesions that were located on the head and neck region. The study was approved by the ethics review board of the Ruhr-University Bochum (#16-5985). For immunohistochemical staining we used the following commercially available antibodies:3 anti-5-hydroxymethylcytosine (5-hmc)-specific antibody (Cat # 39769; Active Motif, Carlsbad, California, USA); anti-5-methylcytosine (5-mc) antibody (Cat # 39649, Active Motif), anti-isocitrate dehydrogenase enzyme (IDH-2) antibody (Cat # ab55271, Abcam, Berlin, Germ...
Source: The British Journal of Dermatology - May 14, 2020 Category: Dermatology Authors: Gambichler T, Steuke AK, Schmitz L, Stockfleth E, Becker JC Tags: Br J Dermatol Source Type: research

A new biomarker for psoriatic arthritis?
PMID: 32394422 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 12, 2020 Category: Dermatology Authors: Kirby B, Fitzgerald O Tags: Br J Dermatol Source Type: research

Erythroderma in a newborn infant suggesting Omenn syndrome.
PMID: 32399979 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 12, 2020 Category: Dermatology Authors: Ren F, Bai X, Elston DM Tags: Br J Dermatol Source Type: research

Sudden appearance of pruritic eruption with comet sign due to Pyemotes sp.
PMID: 32399981 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 12, 2020 Category: Dermatology Authors: Albert M, Finon A, Machet L Tags: Br J Dermatol Source Type: research

Stress and melanoma. Myth or reality?
PMID: 32390139 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 10, 2020 Category: Dermatology Authors: Talaganis JA, Gregoriou S, Stratigos AJ Tags: Br J Dermatol Source Type: research

Congenital multiple clustered dermatofibroma on the abdomen.
PMID: 32390156 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 10, 2020 Category: Dermatology Authors: Mitri F, Haenssle H, Enk A, Toberer F Tags: Br J Dermatol Source Type: research

Topical condyloma treatment: comparative evidence for a common problem.
PMID: 32390160 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 10, 2020 Category: Dermatology Authors: Doiron P Tags: Br J Dermatol Source Type: research

Epidermolysis bullosa: a 2020 perspective.
PMID: 32390183 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 10, 2020 Category: Dermatology Authors: Pope E Tags: Br J Dermatol Source Type: research

Developing a risk prediction model for keratinocyte carcinoma in patients with actinic keratosis.
PMID: 32390191 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 10, 2020 Category: Dermatology Authors: Kim Y, Jorgenson E, Asgari MM Tags: Br J Dermatol Source Type: research

Sensitivity to change and Correlation between Autoimmune Bullous Disease Quality of Life questionnaires ABQOL and TABQOL, and objective severity scores.
Abstract The Autoimmune-Bullous-Disease-Quality-of-Life (ABQOL) score is moderately correlated to pemphigus objective-severity-scores (OSS) (with Pemphigus-Disease-Area-Index (PDAI): R =0.42) but is sensitive to change. The Treatment-of-Autoimmune-Bullous Disease-Quality-of-Life (TABQOL) score is weakly correlated to pemphigus OSS (PDAI: R=0.086) and does not change during the course of treatment. PMID: 32374931 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 6, 2020 Category: Dermatology Authors: Ferries L, Gillibert A, Duvert-Lehembre S, Corbaux C, Alexandre M, Prost-Squarcioni C, Caux F, Delaporte E, Litrowski N, Boulard C, Murrell DF, Joly P, Hebert V Tags: Br J Dermatol Source Type: research

Natural history of naevi: a two-wave study.
CONCLUSION: Naevus counts increased slightly over time at older ages, but this was dependent on body sites. The overall decrease in naevus counts previously reported in cross-sectional studies has not been confirmed by this longitudinal study. PMID: 32364244 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 4, 2020 Category: Dermatology Authors: Ribero S, Zugna D, Spector T, Bataille V Tags: Br J Dermatol Source Type: research

An exploratory, open-label, investigator-initiated study of interleukin-17A (IL-17A) blockade in patients with moderate to severe papulopustular rosacea.
Abstract Currently, few systemic medications are effective for rosacea.1 Recent research has shown elevation of interleukin (IL)-17A in rosacea.2,3 To assess if the IL-17A inhibitor,4, 5 secukinumab, could improve moderate to severe papulopustular rosacea (PPR), an exploratory, open-label, single-arm investigator initiated clinical trial in adults with moderate to severe PPR was performed after Stanford Human Subjects Panel approval. PMID: 32364247 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 4, 2020 Category: Dermatology Authors: Kumar AM, Chiou AS, Shih YH, Li S, Chang ALS Tags: Br J Dermatol Source Type: research

Systematic review examining changes over time and variation in the incidence and prevalence of psoriasis by age and gender.
CONCLUSIONS: Studies on changes over time in the occurrence of psoriasis have contributed to a greater appreciation of the increasing burden of the disease. However, further research is required to determine the reason driving the increase in psoriasis prevalence over time. PMID: 32358790 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 1, 2020 Category: Dermatology Authors: Iskandar IYK, Parisi R, Griffiths CEM, Ashcroft DM, Global Psoriasis Atlas Tags: Br J Dermatol Source Type: research

Estimating the global burden of scabies: what else do we need?
Abstract Scabies is one of the most common disorders identified in any estimate of global skin disease prevalence. Furthermore, quantifying its impact on individuals and societies has been problematic. There has been a lack of clear case definitions and laboratory tests. There have been few epidemiological studies, particularly those focusing on low-income countries, variation in prevalence within high-income countries, or estimates of the effect of scabies on health beyond the skin, such as renal disease or mental well-being. Economic studies are also lacking. However, the new strategy of integrating surveillance...
Source: The British Journal of Dermatology - May 1, 2020 Category: Dermatology Authors: Cox V, Fuller LC, Engelman D, Steer A, Hay RJ Tags: Br J Dermatol Source Type: research

A review of studies looking at quality of life and psychological impact in people with photodermatoses - skin diseases triggered by sunlight.
In conclusion, this study confirmed that patients with photodermatoses experience substantial impact on their quality of life and that more research is needed. This is a summary of the study: Quality of life and psychological impact in the photodermatoses: a systematic review. PMID: 32359112 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 1, 2020 Category: Dermatology Authors: Rutter KJ, Ashraf I, Cordingley L, Rhodes LE Tags: Br J Dermatol Source Type: research

Erratum.
Authors: PMID: 32359114 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 1, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

Taking aim at identifying treatment targets for psoriasis.
PMID: 32359115 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 1, 2020 Category: Dermatology Authors: Takeshita J Tags: Br J Dermatol Source Type: research

Corrigendum.
Authors: PMID: 32359116 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - May 1, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

Depression as a risk factor for the development of psoriasis: a retrospective cohort study in the United Kingdom.
Abstract Psoriasis is a chronic systemic disease with characteristic papules, plaques and nail changes distributed in highly visible locations. This may contribute to the increased prevalence of depression observed in psoriasis patients compared to the general population.1,2 Interestingly, people with depression without systemic inflammatory disorders have increased levels of inflammatory cytokines including tumor necrosis factor-alpha and Interleukin-6,3 as is seen in psoriasis,4 thereby suggesting a potential for a shared inflammatory pathway. Recent evidence supports a link between depression and the subsequent...
Source: The British Journal of Dermatology - April 30, 2020 Category: Dermatology Authors: Vallerand IA, Lewinson RT, Parsons LM, Lowerison MW, Patten SB, Barnabe C Tags: Br J Dermatol Source Type: research

Cutaneous lesions in a patient with COVID-19: are they related?
yer C Abstract A previously healthy 57-year-old woman presented with fever (39 °C) lasting for 4 days, and dry cough and rash appeared 2 days before. Diffuse fixed erythematous blanching maculopapular lesions were present, asymptomatic over the limbs and trunk, with burning sensation over the palms (a, b). She denied any drug intake, excepting paracetamol for fever. Thorax computed tomography scan was typical of COVID-19; nasopharyngeal swab polymerase chain reaction (PCR) confirmed SARS-CoV-2. Infectious enquiry was otherwise negative. Skin biopsy specimen showed slight spongiosis, basal cell vacuolation...
Source: The British Journal of Dermatology - April 30, 2020 Category: Dermatology Authors: Ahouach B, Harant S, Ullmer A, Martres P, Bégon E, Blum L, Tess O, Bachmeyer C Tags: Br J Dermatol Source Type: research

Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases.
CONCLUSIONS: We provide a description of the cutaneous manifestations associated with COVID-19 infection. These may help clinicians approach patients with the disease and recognize paucisymptomatic cases. PMID: 32348545 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 29, 2020 Category: Dermatology Authors: Galván Casas C, Català A, Carretero Hernández G, Rodríguez-Jiménez P, Fernández Nieto D, Rodríguez-Villa Lario A, Navarro Fernández I, Ruiz-Villaverde R, Falkenhain D, Llamas Velasco M, García-Gavín J, Baniandrés O, González-Cruz C, Morillas-L Tags: Br J Dermatol Source Type: research

Organic osmolytes increase expression of specific tight junction proteins in skin and alter barrier function in keratinocytes.
CONCLUSIONS: Treatment of skin with organic osmolytes modulates TJ structure and function, which could contribute to the epidermal barrier. This emphasises a role for organic osmolytes beyond the maintenance of intracellular osmolarity. This could be harnessed to enhance topical therapies for diseases characterised by skin barrier dysfunction. PMID: 32348549 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 29, 2020 Category: Dermatology Authors: El-Chami C, Foster AR, Johnson C, Clausen RP, Cornwell P, Haslam IS, Steward MC, Watson REB, Young HS, O'Neill CA Tags: Br J Dermatol Source Type: research

Measurement properties of the Rajka-Langeland severity score in children and adults with atopic dermatitis.
CONCLUSIONS: Rajka-Langeland score showed good construct validity, reliability, internal consistency and responsiveness in adults and children with AD. PMID: 32348552 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 29, 2020 Category: Dermatology Authors: Silverberg JI, Lei D, Yousaf M, Janmohamed SR, Vakharia PP, Chopra R, Chavda R, Gabriel S, Patel KR, Singam V, Kantor R, Hsu DY Tags: Br J Dermatol Source Type: research

Global reporting of cases of COVID-19 in psoriasis and atopic dermatitis: an opportunity to inform care during a pandemic.
udy groups Abstract We wish to bring your attention to the PsoPROTECT (Psoriasis Patient Registry for Outcomes, Therapy and Epidemiology of Covid-19 infecTion) and SECURE-AD (Surveillance Epidemiology of Coronavirus Under Research Exclusion-Atopic Dermatitis) registries; two urgent global initiatives that address an unmet need for delineating the determinants of COVID-19 outcomes in the common cutaneous immune-mediated inflammatory diseases (IMIDs) psoriasis and atopic dermatitis. PMID: 32348554 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 29, 2020 Category: Dermatology Authors: Mahil SK, Yiu ZZN, Mason KJ, Dand N, Coker B, Wall D, Fletcher G, Bosma A, Capon F, Iversen L, Langan SM, Di Meglio P, Musters A, Prieto-Merino D, Tsakok T, Warren RB, Flohr C, Spuls P, Griffiths CEM, Barker J, Irvine AD, Smith CH, Secure-AD, PsoPROTECT s Tags: Br J Dermatol Source Type: research

The impact of COVID-19 pandemic on patients with chronic plaque psoriasis being treated with biologic therapy: the Northern Italy experience.
Abstract The "severe acute respiratory syndrome coronavirus 2" (SARS-CoV-2) has spread over the four continents, causing the respiratory manifestations of Coronavirus disease-19 (COVID-19) and satisfying the epidemiological criteria for a pandemic [1]. As of April 1, 2020, more than one million COVID-19 positive cases have been identified and more than 54,000 deaths have occurred worldwide [2]. In Italy, 110,574 positive cases, 49,285 hospitalized patients and 13,155 deaths out of a population of 60,359,546 inhabitants, have been reported, respectively [3]. The highest number of deaths occurred in the no...
Source: The British Journal of Dermatology - April 28, 2020 Category: Dermatology Authors: Gisondi P, Facheris P, Dapavo P, Piaserico S, Conti A, Naldi L, Cazzaniga S, Malagoli P, Costanzo A Tags: Br J Dermatol Source Type: research

Rising incidence of basal cell carcinoma in women in Iceland: is it sunbed use?
PMID: 32338370 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 27, 2020 Category: Dermatology Authors: Pandeya N Tags: Br J Dermatol Source Type: research

Infinity hair: a new trichoscopic finding for chemotherapy-induced alopecia.
ini G PMID: 32338372 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - April 27, 2020 Category: Dermatology Authors: Patrì A, Annunziata MC, Cantelli M, Nappa P, Fabbrocini G Tags: Br J Dermatol Source Type: research