Overcoming poor adherence is a major hurdle to managing atopic dermatitis.
PMID: 31571203 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 30, 2019 Category: Dermatology Authors: Strowd LC, Feldman SR Tags: Br J Dermatol Source Type: research

Clinicopathological factors associated with death from thin ( ≤1.00mm) melanoma.
Clinicopathological factors associated with death from thin (≤1.00mm) melanoma. Br J Dermatol. 2019 Sep 28;: Authors: Claeson M, Baade P, Brown S, Soyer HP, Smithers BM, Green AC, Whiteman DC, Khosrotehrani K Abstract BACKGROUND: Thin cutaneous melanomas (≤1.00mm) are increasing worldwide, causing around a quarter of all melanoma deaths in the USA and Australia. Identification of predictive factors for potentially fatal thin melanomas could allow better use of resources for follow-up. OBJECTIVES: To identify clinicopathological factors associated with fatal thin melanomas. METHODS: Thi...
Source: The British Journal of Dermatology - September 28, 2019 Category: Dermatology Authors: Claeson M, Baade P, Brown S, Soyer HP, Smithers BM, Green AC, Whiteman DC, Khosrotehrani K Tags: Br J Dermatol Source Type: research

Challenging a paradigm: Skin sensitivity to sodium lauryl sulfate is independent of atopic diathesis.
CONCLUSIONS: We found no association of increased skin irritability to SLS with atopic skin diathesis, atopic dermatitis, allergic rhinitis, or allergic asthma in a large patient cohort. It therefore seems that the test of skin irritability with SLS, which is common practice in many centers so far, does not allow to predict the susceptibility to irritant eczematous inflammation in atopic vs. non-atopic individuals. PMID: 31562780 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 28, 2019 Category: Dermatology Authors: Heetfeld AB, Schill T, Schröder SS, Forkel S, Mahler V, Pfützner W, Schön MP, Geier J, Buhl T Tags: Br J Dermatol Source Type: research

Could psoralen plus ultraviolet A1 ("PUVA1") work? Depth penetration achieved by phototherapy lamps.
Could psoralen plus ultraviolet A1 ("PUVA1") work? Depth penetration achieved by phototherapy lamps. Br J Dermatol. 2019 Sep 28;: Authors: Barnard IRM, Eadie E, McMillan L, Moseley H, Brown T, Wood K, Dawe R Abstract Psoralen and ultraviolet A (PUVA) is useful in treating various hand and foot skin diseases.1 Most cases of psoriasis respond well to phototherapy or PUVA. However, for some diseases, such as palmoplantar pustular psoriasis, PUVA is not always sufficient to produce therapeutic effect. If PUVA fails, it is sometimes necessary to progress to other treatments such as Grenz ray ther...
Source: The British Journal of Dermatology - September 28, 2019 Category: Dermatology Authors: Barnard IRM, Eadie E, McMillan L, Moseley H, Brown T, Wood K, Dawe R Tags: Br J Dermatol Source Type: research

Isotretinoin is indirectly effective in sebocytes.
ulis CC, Törőcsik D Abstract In a recently published research letter Burney et al. demonstrated that isotretinoin (13-cis-retinoic acid, 13CRA) induced acnegenic changes in SEB-1 cultured human sebocytes1 . However, Melnik et al., suggested that the observed changes may largely be influenced by the Simian virus (SV)-40 immortalization of the used cell line, which may inhibit the p53 pathway and together with 13CRA lead to changes, such as the down-regulation of the forkhead box O (FoxO) pathway. In contrast, they found that the FoxO pathway was upregulated in samples from patients receiving 13CRA treatment f...
Source: The British Journal of Dermatology - September 28, 2019 Category: Dermatology Authors: Kovács D, Hegyi K, Szegedi A, Deák D, Póliska S, Rühl R, Zouboulis CC, Törőcsik D Tags: Br J Dermatol Source Type: research

Efficacy and safety of dupilumab in Japanese adults with moderate-to-severe atopic dermatitis: a subanalysis of three clinical trials.
CONCLUSIONS: Dupilumab alone or with TCS improved signs and symptoms of AD, had an acceptable safety profile, and suppressed biomarkers of type 2 inflammation compared to placebo in Japanese adult patients with moderate-to-severe AD. PMID: 31564057 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 28, 2019 Category: Dermatology Authors: Katoh N, Kataoka Y, Saeki H, Hide M, Kabashima K, Etoh T, Igarashi A, Imafuku S, Kawashima M, Ohtsuki M, Fujita H, Arima K, Takagi H, Chen Z, Shumel B, Ardeleanu M Tags: Br J Dermatol Source Type: research

Validation of the Dutch Quality of Life in Hand Eczema Questionnaire (QOLHEQ).
CONCLUSION: The Dutch version of the QOLHEQ has a good structural validity and reproducibility and has a high single-score validity and moderate responsiveness. An improvement of ≥15 points should be regarded a real, important change within the Dutch population. PMID: 31560803 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 27, 2019 Category: Dermatology Authors: Oosterhaven JAF, Ofenloch RF, Schuttelaar MLA Tags: Br J Dermatol Source Type: research

IL-17C is Elevated in Lesional Tissue of Hidradenitis Suppurativa.
Abstract Interleukin 17C (IL-17C) is a cytokine produced by epithelial cells, including keratinocytes, in response to multiple stimuli1 such as IL-17A, IL-17F, TNF-α, bacterial stimuli and toll-like receptor agonists1 . When produced in keratinocytes, IL-17C mediates the production of inflammatory molecules, including IL-1β, IL-8, CXCL1, and IL-36γ. In addition, IL-17C induces further elevation in IL-17A and IL-17F in Th17 cells in a pro-inflammatory positive amplification loop2,3 . PMID: 31556100 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 26, 2019 Category: Dermatology Authors: Navrazhina K, Frew JW, Krueger JG Tags: Br J Dermatol Source Type: research

EBGene trial: Patient pre-selection outcomes for the European GENEGRAFT ex vivo phase I/II gene therapy trial for recessive dystrophic epidermolysis bullosa.
Abstract Recessive dystrophic epidermolysis bullosa (RDEB) is an inherited skin fragility disorder caused by loss-of-function mutations in COL7A1 encoding type VII collagen (C7), the major component of anchoring fibrils (AFs) that ensure dermal-epidermal adherence. From birth, RDEB patients endure lifelong skin and mucosal blistering with both local and systemic complications including aggressive metastatic squamous cell carcinomas (SCC).1 Currently, treatments are only symptomatic although clinical studies of novel therapeutics, including gene2 and cell3 therapies are emerging. One potential safety issue with suc...
Source: The British Journal of Dermatology - September 26, 2019 Category: Dermatology Authors: Gaucher S, Lwin SM, Titeux M, Abdul-Wahab A, Pironon N, Izmiryan A, Miskinyte S, Ganier C, Duchatelet S, Mellerio JE, Bourrat E, McGrath JA, Hovnanian A Tags: Br J Dermatol Source Type: research

Pain severity and use of analgesic medication in adults with atopic dermatitis: a cross-sectional study.
CONCLUSION: Patients with AD did not display increased use of pain medication but few had severe disease. The close observed relationship between itch and pain, highlights the potential benefits of established AD treatments to also reduce skin pain in AD. PMID: 31556099 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 25, 2019 Category: Dermatology Authors: Thyssen JP, Halling-Sønderby AS, Wu JJ, Egeberg A Tags: Br J Dermatol Source Type: research

Trends in epidemiology of melanoma in situ in Greece: Data from a melanoma reference center during the period 2000-2018.
Abstract The incidence of melanoma in situ (MIS) is increasing more rapidly than this of invasive,1 . According to SEER database it represents one of the most fast-growing malignancies2 . Reported data from South Europe mostly include information from Italy and Spain3 . We tried to study the epidemiological trends of MIS in Greece. PMID: 31549388 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 23, 2019 Category: Dermatology Authors: Kostaki M, Plaka M, Stergiopoulou A, Kypreou K, Chardalia V, Chasapi V, Polydorou D, Stratigos A Tags: Br J Dermatol Source Type: research

Acquired epidermodysplasia verruciformis: a ten-year anniversary update.
Abstract Epidermodysplasia verruciformis (EV), a rare dermatologic condition, was first described by Lewandosky and Lutz in 1922. Subsequently, the disease was linked to nonsense mutations in EVER1 and EVER2 which were proposed to enhance susceptibility to EV-specific β-human papillomavirus (HPV) subtypes. However, genetic alterations alone did not adequately explain the propensity for EV to arise in immunocompromised patients, especially those who are human immunodeficiency virus (HIV)-positive or who have undergone transplantation. PMID: 31545504 [PubMed - as supplied by publisher] (Source: The British...
Source: The British Journal of Dermatology - September 23, 2019 Category: Dermatology Authors: Limmer AL, Wu JH, Doan HQ, Rady PL, Tyring SK Tags: Br J Dermatol Source Type: research

An indirect comparison of long-term efficacy of every-two-week dosing versus recommended dosing of ixekizumab in patients who had sPGA > 1 at week 12.
CONCLUSIONS: Among patients who did not have clear or almost clear skin at Week 12, nearly 30% more patients treated continuously with ixekizumab Q2W in IXORA-P had clear or almost clear skin at Week 52 when compared indirectly with those treated with labeled psoriasis dosing in integrated UNCOVER studies. PMID: 31545506 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 23, 2019 Category: Dermatology Authors: Papp K, Maari C, Cauthen A, Gooderham M, Spelman L, Yamanaka K, Polzer P, Zhang L, Osuntokun O, Augustin M Tags: Br J Dermatol Source Type: research

Long-term efficacy and safety of sonidegib in patients with advanced basal cell carcinoma: 42-month analysis of the phase 2 randomised, double-blind BOLT study.
CONCLUSIONS: Sonidegib demonstrated sustained efficacy and a manageable safety profile. Final BOLT results support sonidegib as a viable treatment option for laBCC and mBCC. PMID: 31545507 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 23, 2019 Category: Dermatology Authors: Dummer R, Guminksi A, Gutzmer R, Lear JT, Lewis KD, Chang ALS, Combemale P, Dirix L, Kaatz M, Kudchadkar R, Loquai C, Plummer R, Schulze HJ, Stratigos AJ, Trefzer U, Squittieri N, Migden MR Tags: Br J Dermatol Source Type: research

Post-traumatic stress disorder in patients with autoimmune blistering diseases.
Abstract Post-Traumatic Stress Disorder (PTSD) can develop when an individual has an experience that threatens their psychological or physical integrity.1 PTSD has been observed in patients with sudden-onset, life-altering or life-threatening health conditions ranging from cancer and asthma2,3 to Stevens-Johnson Syndrome,4 but has not been evaluated in chronic, relapsing inflammatory dermatologic diseases such as autoimmune bullous disease. PTSD may also directly impact immune function and a wide range of immune based disorders; previous studies of PTSD patients have reported a higher prevalence of autoimmune diso...
Source: The British Journal of Dermatology - September 23, 2019 Category: Dermatology Authors: Wei EX, Li SJ, Mostaghimi A Tags: Br J Dermatol Source Type: research

Successful treatment of recalcitrant plantar warts by carbon dioxide laser with a computerized scanner.
Abstract Warts are benign neoplasms of the skin and mucosa caused by human papillomavirus (HPV) infection.1 The most common treatments for wart are topical application of salicylic acid and cryotherapy. Other modalities include chemical agents, contact sensitizing agents and surgical excision.2 Laser modalities, including carbon dioxide (CO2 ), pulsed dye and neodymium-doped: yttrium-aluminum-garnet lasers, have also been used to treat recalcitrant plantar warts. PMID: 31545511 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 23, 2019 Category: Dermatology Authors: Kagoyama K, Makino T, Shimizu T Tags: Br J Dermatol Source Type: research

Patient-reported health not associated with keratinocyte carcinoma treatment choice in a Medicare cohort of older adults.
Abstract Keratinocyte carcinomas (KCs; basal cell carcinoma [BCC] and squamous cell carcinoma [SCC]), are common in older adults, with 2.1 million yearly in United States (US) Medicare patients.1 Common treatments include destruction (typically electrodessication and curettage), surgical excision, and Mohs micrographic surgery (MMS), all of which can offer cure rates>90%2,3 (highest for MMS, followed by excision, then destruction). PMID: 31539166 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 20, 2019 Category: Dermatology Authors: Wehner MR, Kwong PL, Kurichi JE, Xie D, Hennessy S, Margolis DJ Tags: Br J Dermatol Source Type: research

Nosocomial outbreak of crusted scabies in immunosuppressed patients caused by Sarcoptes scabiei var. canis.
We report a nosocomial outbreak of crusted scabies due to S. scabiei var. canis in immunosuppressed patients. PMID: 31535362 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 19, 2019 Category: Dermatology Authors: Stingeni L, Tramontana M, Principato M, Moretta I, Principato S, Bianchi L, Hansel K Tags: Br J Dermatol Source Type: research

The sentinel node biopsy has not come of age (cover page).
Abstract We are stunned that Dr Jane McGregor believes that "The sentinel node biopsy (SLNB) has come of age" [1]. We do not accept this claim. SLNB is still younger and less experienced than the pathological criteria of Breslow thickness and ulceration. SLNB provides no survival benefit for melanoma patients [2] and results in complications, including 6% risk of lymphoedema [2]. The vast majority of melanoma patients have negative SLNB and cannot possibly benefit from the procedure. PMID: 31536641 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 19, 2019 Category: Dermatology Authors: Sladden M, Zagarella S, Popescu C, Bigby M Tags: Br J Dermatol Source Type: research

Evaluation of haematopoietic stem cell transplantation in patients diagnosed with cutaneous T cell lymphoma at a tertiary care centre: Should we avoid chemotherapy in conditioning regimes?
Abstract Advanced stage mycosis fungoides (MF) and Sézary syndrome (SS) account for ~30% of patients with cutaneous T-cell lymphomas (CTCL). The prognosis is poor with a median survival of 36 months.1 Treatments rarely result in durable remissions and recent management guidelines recommend allogeneic haematopoietic stem cell transplant (HSCT) for eligible patients as the best chance of improved survival. PMID: 31536644 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 19, 2019 Category: Dermatology Authors: Ritchie S, Qureshi I, Molloy K, Yoo J, Shah F, Stevens A, Irwin C, Chaganti S, Scarisbrick JJ Tags: Br J Dermatol Source Type: research

The Association of Smoking and Socioeconomic status on Cutaneous Melanoma: a population based, data linkage, case-control study.
CONCLUSION: Our study has demonstrated that smoking appeared to be associated with reduced incidence of melanoma. Whilst smoking increases overall mortality, no association was observed with melanoma-specific mortality. Further work is required to determine if there is a biological mechanism underlying this relationship or an alternative explanation, such as survival bias. PMID: 31529485 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 17, 2019 Category: Dermatology Authors: Gibson JAG, Dobbs TD, Griffiths R, Song J, Akbari A, Whitaker S, Watkins A, Langan SM, Hutchings HA, Lyons RA, Whitaker IS Tags: Br J Dermatol Source Type: research

Mohs micrographic surgery versus standard surgical excision?
Abstract DEAR EDITOR , the article by van Lee and colleagues raises a rarely discussed but crucial issue 1 . Namely that specimens from standard surgical excision were handled pathologically by a vertical slicing method, although understandably details were limited. PMID: 31529459 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 16, 2019 Category: Dermatology Authors: Slater DN Tags: Br J Dermatol Source Type: research

Mohs micrographic surgery versus standard surgical excision?: reply from authors.
Abstract In a letter to the editor by Slater et al as a reaction to our article on the recurrence rates of cutaneous squamous cell carcinoma of the head and neck after Mohs micrographic surgery versus standard excision1 , it is questioned how the specimens from standard surgical excision were handled pathologically. In our study, in both study centres during the entire inclusion period (2003-2012), specimens were handled pathologically in a standardized and high quality manner which is in line with the 2012 Royal College of Pathologists ( RCPath) skin cancer dataset for primary cutaneous invasive squamous cell car...
Source: The British Journal of Dermatology - September 16, 2019 Category: Dermatology Authors: van Lee CB, Mooyaart AL, van den Bos RR Tags: Br J Dermatol Source Type: research

Quality of reporting in systematic reviews published in dermatology journals.
CONCLUSIONS AND RELEVANCE: SR reporting in dermatology journals is often inadequate but improving over time; protocol registration is associated with better reporting. PMID: 31529461 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 16, 2019 Category: Dermatology Authors: Croitoru DO, Huang Y, Kurdina A, Chan AW, Drucker AM Tags: Br J Dermatol Source Type: research

Comparing the efficacy of field treatments for actinic keratosis: A critical appraisal of a randomized trial in the New England Journal of Medicine.
CONCLUSION: Jansen et al conclude that one year after treatment, fluorouracil was significantly more effective at AK reduction than imiquimod, MAL-PDT, or ingenol mebutate. PMID: 31529471 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 16, 2019 Category: Dermatology Authors: Wehner MR Tags: Br J Dermatol Source Type: research

Dose and time effects of solar simulated ultraviolet radiation on the in vivo human skin transcriptome.
CONCLUSIONS: The UVR doses of this acute study are readily achieved daily during sunny holidays, suggesting that skin transcriptional profile of "typical" holiday makers is markedly deregulated. PMID: 31529490 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 16, 2019 Category: Dermatology Authors: Bustamante M, Hernandez-Ferrer C, Tewari A, Sarria Y, Harrison GI, Puigdecanet E, Nonell L, Kang W, Friedländer MR, Estivill X, González JR, Nieuwenhuijsen M, Young AR Tags: Br J Dermatol Source Type: research

Brentuximab a novel antibody therapy: Real-World Use Confirms Efficacy and Tolerability for CD30 positive cutaneous lymphoma.
Abstract Brentuximab Vedotin (BV) is a CD30 antibody drug complex that has a direct cytotoxic effect against CD30-expressing cells including its microenvironment1 . ALCANZA, a recent phase-3 randomised controlled international clinical trial showed superior response rate with BV (67%) compared to conventional therapies (physician's choice) with either methotrexate or bexarotene (20%) in the treatment of CD30+ mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma (pcALCL). Furthermore, a significantly improved duration of response lasting at least 4months (ORR4) was reported in 56% of patients...
Source: The British Journal of Dermatology - September 16, 2019 Category: Dermatology Authors: Engelina S, Saggu M, Yoo J, Shah F, Stevens A, Irwin C, Chaganti S, Scarisbrick JJ Tags: Br J Dermatol Source Type: research

Persistence of anti-envoplakin and anti-periplakin antibodies in a case of Paraneoplastic Pemphigus 20 years after remission.
e; JM Abstract Paraneoplastic pemphigus (PNP), also known as Paraneoplastic Autoimmune Multiorgan Syndrome (PAMS) is an autoimmune blistering disease associated with neoplasms, especially lymphoproliferative disorders. Early case reports and series described a poor prognosis. In a recent review of all reported patients until 2016, first year survival rate was 62.4%.1 Here, we describe the long survival of a previously reported case,2 to whom serologic studies were performed during follow-up. PMID: 31529517 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 16, 2019 Category: Dermatology Authors: Riera-Monroig J, Iranzo P, Ishii N, Hashimoto T, Mascaró JM Tags: Br J Dermatol Source Type: research

A risk prediction model for development of subsequent primary melanoma in a population-based cohort.
CONCLUSIONS: The risk of developing a subsequent primary melanoma varies considerably between individuals and is particularly high for those with two or more previous melanomas. This risk prediction model and nomograms enables estimation of absolute risk of subsequent melanoma based on an individual's risk factors and can be used to tailor surveillance intensity, communicate risk and provide patient education. PMID: 31520533 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 14, 2019 Category: Dermatology Authors: Cust AE, Badcock C, Smith J, Thomas NE, Haydu LE, Armstrong BK, Law MH, Thompson JF, Kanetsky PA, Begg CB, Shi Y, Kricker A, Orlow I, Sharma A, Yoo S, Leong SF, Berwick M, Ollila DW, Lo S Tags: Br J Dermatol Source Type: research

Principal component analysis of seven skin ageing features identifies three main types of skin ageing.
CONCLUSION: Using a hypothesis-free approach, we identified three major underlying phenotypes associated with extrinsic ageing. Associations between determinants for skin ageing differed in magnitude and direction per component. PMID: 31519034 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 13, 2019 Category: Dermatology Authors: Pardo LM, Hamer MA, Liu F, Velthuis P, Kayser M, Gunn DA, Nijsten T Tags: Br J Dermatol Source Type: research

Cutibacterium acnes in acne pathophysiology - the chicken or the egg?
PMID: 31515808 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 12, 2019 Category: Dermatology Authors: Ochsendorf FR Tags: Br J Dermatol Source Type: research

A comparative analysis of histone deacetylase inhibitors for the treatment of mycosis fungoides  and Sézary syndrome.
A comparative analysis of histone deacetylase inhibitors for the treatment of mycosis fungoides and Sézary syndrome. Br J Dermatol. 2019 Sep 12;: Authors: Papps T, McCormack C, Buelens O, Van der Weyden C, Twigger R, Campbell BA, Dickinson M, Prince HM Abstract Two histone deacetylase inhibitors (HDACi), vorinostat and romidepsin have been approved by regulatory agencies in parts of the world for the treatment of relapsed/refractory Mycosis Fungoides (MF) and Sézary Syndrome (SS) based on positive Phase II trial results.1,2 Panobinostat has activity in MF/SS, and is approved in the ...
Source: The British Journal of Dermatology - September 12, 2019 Category: Dermatology Authors: Papps T, McCormack C, Buelens O, Van der Weyden C, Twigger R, Campbell BA, Dickinson M, Prince HM Tags: Br J Dermatol Source Type: research

In vitro ovicidal activity of current and under-development scabicides - which treatments kill scabies eggs?
Abstract Scabies is highly prevalent worldwide with a significant DALYs global burden, affecting 100-200 million people annually.1 In hyper-endemic tropical regions, the link with secondary bacterial infections is increasingly recognised. Group A streptococcal and staphylococcal pyoderma can cause bacteraemia,2 glomerulonephritis and acute rheumatic fever potentially leading to rheumatic heart disease. Current scabies treatments are few in number and suboptimal. As neuroinhibitors they are expected to kill motile stages but could be poorly ovicidal. Emerging drug resistances in the parasites are a further concern....
Source: The British Journal of Dermatology - September 11, 2019 Category: Dermatology Authors: Bernigaud C, Fernando DD, Lu H, Taylor S, Hartel G, Guillot J, Chosidow O, Fischer K Tags: Br J Dermatol Source Type: research

The clinical, immunological and pathological features for relapse of pemphigus herpetiformis: a univariate analysis of 26 cases.
Abstract Pemphigus herpetiformis (PH) is a rare autoimmune blistering disease that accounts for only about 7% of all pemphigus patients1 . Various factors may contribute to PH relapse that requires hospitalization and reintroduction of a high-dose of the first-line drugs such as glucocorticoids, potentially leading to severe complications and high medical cost. Our study sought to identify the clinical, immunological, and pathological characteristics in PH patients as well as the risk factors for relapse of PH. PMID: 31506934 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 10, 2019 Category: Dermatology Authors: Wang YM, Mao X, Zhao WL, Wang YH, Zuo YG, Jin HZ, Li L Tags: Br J Dermatol Source Type: research

Musculoskeletal ultrasound can improve referrals from dermatology to rheumatology for patients with psoriasis.
Abstract Psoriasis affects 1-3% of the population and up to 1/3 of psoriasis patients have underlying psoriatic arthritis (PsA)1 . Non-specific musculoskeletal complaints are even higher, being around 50%2 . Detecting early signs of PsA and early treatments are crucial to improve the outcomes to prevent progressive, damaging arthritis3 . Due to the high frequency of non-specific pain in psoriasis, it is not possible for every psoriasis patient with joint pain to be assessed by a rheumatologist. PMID: 31505032 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 10, 2019 Category: Dermatology Authors: Solmaz D, Bakirci S, Al Onazi A, Al Osaimi N, Fahim S, Aydin SZ Tags: Br J Dermatol Source Type: research

Practical Screening for Depression in Dermatology: Using Technology to Improve Care.
Abstract Increased emphasis has been placed on screening for co-morbid mental health conditions by all physicians, including dermatologists. Reports suggest that approximately 30% of all dermatology patients experience some form of mental health disorder.1 Mental and physical health have a complex interplay-dermatology patients with depression are less adherent and have more recalcitrant skin disease.2 Recently, the Patient Health Questionnaire-2 (PHQ-2) was recommended for regular use by dermatologists to screen for depression and suicidal ideation.3 While we agree that screening is essential, we contend that the...
Source: The British Journal of Dermatology - September 10, 2019 Category: Dermatology Authors: Gaufin M, Hess R, Hopkins ZH, Biber JE, Secrest AM Tags: Br J Dermatol Source Type: research

Trends in healthcare utilization for infantile hemangioma in the United States.
Abstract Infantile hemangiomas (IH) are the most common vascular tumor of infancy1 . Most hemangiomas follow a predictable pattern with proliferation followed by slow involution and many do not require medical or surgical intervention. However, some hemangiomas cause complications, including disfigurement, visual obstruction and/or functional impairment, which require therapeutic intervention.2 Since the discovery of beta blockers as effective topical and oral therapy for IH, hemangioma specialists suggest early therapy and referral for IH to prevent permanent sequalae3 . Yet, little is known about utilization pat...
Source: The British Journal of Dermatology - September 10, 2019 Category: Dermatology Authors: Singh P, Chamlin S, Hignett E, Silverberg JI Tags: Br J Dermatol Source Type: research

Inhibition of interleukin-17: a new therapeutic approach for graft-versus-host disease?
PMID: 31502240 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 9, 2019 Category: Dermatology Authors: Gillihan R, Motaparthi K Tags: Br J Dermatol Source Type: research

Secukinumab for treatment of nail psoriasis: results from the TRANSFIGURE trial.
PMID: 31495921 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 9, 2019 Category: Dermatology Authors: Kloczko E, Maybury CM Tags: Br J Dermatol Source Type: research

Does systemic treatment of psoriasis reduce the risk of comorbidities?
PMID: 31495927 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 9, 2019 Category: Dermatology Authors: Gisondi P Tags: Br J Dermatol Source Type: research

immunological characterisation of 14 cases of dipeptidyl peptidase 4 inhibitor-associated bullous pemphigoid: a single centre study.
Abstract Recently, we analysed a case series of bullous pemphigoid (BP) for antibodies to various domains of BP180 using ELISA and immunoblotting, and showed that dipeptidyl peptidase 4 inhibitor-associated BP (DPP4i-BP) patients tend to demonstrate non-inflammatory phenotype and positive reactivity to midportion of BP180.1 However, the. PMID: 31498425 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 9, 2019 Category: Dermatology Authors: Hayashi M, Tsunoda T Tags: Br J Dermatol Source Type: research

A novel patient-reported outcome for paediatric localized scleroderma: A qualitative assessment of content validity.
CONCLUSIONS: Content validity was supported by the patient-centred development process of the outcome measure and via direct feedback from individuals with LS and their families. Although an important first step, the resulting PRO, termed the "Localized Scleroderma Quality of Life Instrument", should be further evaluated in a larger sample before being implemented. PMID: 31498874 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 9, 2019 Category: Dermatology Authors: Zigler CK, Ardalan K, Lane S, Schollaert KL, Torok KS Tags: Br J Dermatol Source Type: research

Home phototherapy: experience of setting up a new service in the U.K.'s National Health Service.
Abstract Home phototherapy was first reported for patients with psoriasis in a 19791 . A randomized controlled study in 2009 (PLUTO)2 comparing home with hospital based phototherapy for psoriasis showed home phototherapy to be a safe, effective and cost effective method of treatment delivery. Despite this, the uptake of home phototherapy in the UK has been very poor. Until now, Ninewells Hospital in Dundee is the only UK centre to offer a National Health Service (NHS) home phototherapy service3 . PMID: 31498877 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 9, 2019 Category: Dermatology Authors: Warburton KL, Ward A, Turner D, Goulden V Tags: Br J Dermatol Source Type: research

Image Gallery: Segmental neurofibromatosis type 1 on the face. A 30-year delay in diagnosis.
, Bañuls J PMID: 31494920 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 8, 2019 Category: Dermatology Authors: Vergara-de Caso E, Schneller-Pavelescu L, Martínez-Hergueta MC, Álvarez-Chinchilla PJ, Poveda-Montoyo I, Bañuls J Tags: Br J Dermatol Source Type: research

Evaluating rosacea noninvasively and objectively.
PMID: 31494921 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 8, 2019 Category: Dermatology Authors: Tan J Tags: Br J Dermatol Source Type: research

The mosaic hedgehog spectrum: another lesson on the polymorphy of mosaicism.
PMID: 31494922 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 8, 2019 Category: Dermatology Authors: Zenker M Tags: Br J Dermatol Source Type: research

Continued weekly adalimumab is an effective strategy in patients with hidradenitis suppurativa who show at least partial response to therapy at week 12.
PMID: 31494923 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 8, 2019 Category: Dermatology Authors: Micheletti RG Tags: Br J Dermatol Source Type: research

Are hypertrophic scars and keloids the same?
PMID: 31494925 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 8, 2019 Category: Dermatology Authors: Tapking C, Prasai A, Branski LK Tags: Br J Dermatol Source Type: research

Atopic dermatitis epidemiology: moving beyond cross-sectional studies.
PMID: 31494927 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 8, 2019 Category: Dermatology Authors: Silverberg JI Tags: Br J Dermatol Source Type: research

Improving the diagnosis of autoimmune blistering dermatoses of the oral mucosa.
PMID: 31494928 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 8, 2019 Category: Dermatology Authors: Maglie R, Hertl M Tags: Br J Dermatol Source Type: research