Dermoscopy and reflectance confocal microscopy for early diagnosis of amelanotic/hypomelanotic melanoma: still a long way to go?
PMID: 32090328 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 22, 2020 Category: Dermatology Authors: Chi CC Tags: Br J Dermatol Source Type: research

Artificial intelligence in dermatology: the 'unsupervised' learning.
Abstract The potential areas of application of artificial intelligence in dermatology are ever increasing. With the wide availability of smartphones equipped with high-resolution cameras and impressive processing powers, harnessing these capabilities using machine learning (ML) could open new prospects in the management of dermatological disorders. Du-Harpur et al. have done a commendable job reviewing the utility of artificial intelligence in dermatology in an easily understandable manner for most dermatologists. PMID: 32086797 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 20, 2020 Category: Dermatology Authors: Acharya P, Mathur M Tags: Br J Dermatol Source Type: research

The interaction between filaggrin mutations and hard domestic water on the risk of early-onset atopic dermatitis.
Abstract We read with interest the article by Jabbar-Lopez et al.,1 showing a significant interaction between filaggrin gene (FLG) loss-of-function mutations and exposure to domestic water hardness (≤256 mg/L versus>256 mg/L calcium carbonate (CaCO3 ) on the risk of atopic dermatitis (AD) at 36 months of age. PMID: 32083316 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 20, 2020 Category: Dermatology Authors: Halling AS, Bager P, Skov L, Zachariae C, Wohlfahrt J, Melbye M, Thyssen JP Tags: Br J Dermatol Source Type: research

Topical imiquimod monotherapy for indolent primary cutaneous B-cell lymphomas (PCBCL): a single-institution experience.
Abstract Primary cutaneous B-cell lymphomas (PCBCL) are rare extranodal lymphoproliferative disorders that present in the skin and seldom disseminate systemically. The World Health Organization - European Organization for Research and Treatment of Cancer (WHO-EORTC) define three PCBCL types: primary cutaneous marginal zone lymphoma (PCMZL) and primary cutaneous follicle-center lymphoma (PCFCL) are histologically low grade and clinically indolent; primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) is clinically and histologically aggressive. Staging is based on number, size, and areas of distrib...
Source: The British Journal of Dermatology - February 19, 2020 Category: Dermatology Authors: Hwang S, Johnson A, Fabbro S, Hastings J, Haverkos B, Chung C, Porcu P, William B Tags: Br J Dermatol Source Type: research

Indoor tanning use is associated with psoriasis from the Nurses' Health Study II.
Abstract Psoriasis is a chronic immune-mediated disease of the skin that affects approximately 2% of the US and Europe population1 . The disease presents a significant burden for affected individuals and negatively affects their quality of life. Environmental and life-style factors play important roles in this disease, and several complex disorders have also been linked to psoriasis1,2 . Phototherapy, performed under medical supervision, is an effective treatment for psoriasis1 . Indoor tanning produces artificial ultraviolet radiation and has been shown to increase the risk of skin cancer and accelerate skin agin...
Source: The British Journal of Dermatology - February 19, 2020 Category: Dermatology Authors: Choong CK, Merola JF, Han J, Li X Tags: Br J Dermatol Source Type: research

American Cutaneous Leishmaniasis in French Guiana: a retrospective comparison between liposomal amphotericin B and meglumine antimoniate.
zot R Abstract New World cutaneous leishmaniasis (CL) is endemic in many countries of Latin America, including French Guiana 1 . While pentamidine is the first-line treatment against Leishmania guyanensis in this territory 2 , pentavalent antimonials such as meglumine antimoniate (MA) are recommended in case of L. braziliensis or pentamidine-resistant strains of other species 2 . Liposomal amphotericin B (L-AmB) (Ambisome ®) is widely used against fungi and visceral leishmaniasis 3 . However, data concerning its efficacy in New World CL are scarce and contradictory 4-7 . Due to a shortage in MA, the Cayenne Ho...
Source: The British Journal of Dermatology - February 19, 2020 Category: Dermatology Authors: Senchyna A, Simon S, Cissé H, Ginouves M, Prevot G, Alcoba G, Demar M, Couppie P, Blaizot R Tags: Br J Dermatol Source Type: research

Cross-sectional study identifies lower risk of Staphylococcus aureus nasal colonisation in Danish blood donors with Hidradenitis suppurativa symptoms.
Abstract Hidradenitis suppurativa (HS) is a chronic skin disease with point prevalence between 1% and 4%, characterized by recurrent inflammation and painful formation of nodules in the intertriginous areas of the skin. In some patients, these lesions progress into the formation of abscesses and/or tunnels, ultimately causing restrictive scaring, and health-related quality of life impairment. Growing evidence suggests that the primary event is infundibular hyperkeratosis at the terminal follicles causing follicle dilatation and perifollicular inflammation followed by cyst formation.1 However, the exact aetiology o...
Source: The British Journal of Dermatology - February 19, 2020 Category: Dermatology Authors: Dinh KM, Erikstrup LT, Andersen RK, Andersen PS, Mikkelsen S, Kjerulff BD, Burgdorf KS, Hansen TF, Nielsen KR, Hjalgrim H, Jemec GB, Ullum H, Erikstrup C, Pedersen OB Tags: Br J Dermatol Source Type: research

Ongoing cancer burden after a diagnosis of cutaneous squamous cell carcinoma.
PMID: 32077097 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 18, 2020 Category: Dermatology Authors: Youlden DR, Baade PD Tags: Br J Dermatol Source Type: research

Assessing the Effect of Clinical Trial Evidence and Anecdote on Caregivers' Willingness to Use Corticosteroids: A Randomized Controlled Trial. A Critical Appraisal.
Abstract AIM: Johnson et al. [1] aimed to assess caregivers' willingness to treat childhood atopic dermatitis (AD) with a corticosteroid when presented with clinical trial evidence, anecdote, or both. SETTING AND DESIGN: This prospective parallel group (1:1; 8 groups) randomised control trial was carried out with caregivers recruited from a tertiary care dermatology clinic in the United States of America (USA) and an online crowdsourcing platform using caregivers who may not have had a child with AD. STUDY EXPOSURE: Caregivers were randomised to 8 groups. The 3 main groups were given clinical trial evide...
Source: The British Journal of Dermatology - February 17, 2020 Category: Dermatology Authors: Brown A, Tsianou Z, Williams H Tags: Br J Dermatol Source Type: research

Results from the BJD survey on readership views towards clinical practice guidelines.
The objective of this study was to survey the BJD readership's demographics, utility of and attitudes towards CPGs. PMID: 32072620 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 17, 2020 Category: Dermatology Authors: Yiu ZZN, Jabbar-Lopez ZK, Ahmed S, Mohd Mustapa MF, Chi CC, Flohr C Tags: Br J Dermatol Source Type: research

Implementation of dupilumab in routine care of atopic eczema. Results from the German national registry TREATgermany.
warz B, Bell M, Neubert K, Effendy I, Bieber T, Homey B, Gerlach B, Tchitcherina E, Stahl M, Schwichtenberg U, Rossbacher J, Buck P, Mempel M, Beissert S, Werfel T, Weidinger S, Schmitt J, TREATgermany study group Abstract The German atopic eczema (AE)-registry TREATgermany is a non-interventional multicenter patient cohort study for adult patients with currently moderate-to-severe disease activity or current/previous anti-inflammatory systemic treatment.1,2 Dupilumab has demonstrated to be an effective treatment for patients with moderate-to-severe AE in clinical trials.3-5 Real world evidence is now needed to ev...
Source: The British Journal of Dermatology - February 17, 2020 Category: Dermatology Authors: Abraham S, Haufe E, Harder I, Heratizadeh A, Kleinheinz A, Wollenberg A, Weisshaar E, Augustin M, Wiemers F, Zink A, Biedermann T, von Kiedrowski R, Hilgers M, Worm M, Pawlak M, Sticherling M, Fell I, Handrick C, Schäkel K, Staubach P, Asmussen A, Schwar Tags: Br J Dermatol Source Type: research

Where do we stand with immune checkpoint blockade for advanced cutaneous squamous cell carcinoma? A systematic review and critical appraisal of existing evidence.
t MV Abstract Immune checkpoint blockade (ICB) has tremendously changed the field of oncological therapy. Recently, the PD-1-blocking antibody cemiplimab was approved by the FDA and the EMA for the treatment of advanced cutaneous squamous cell carcinoma (cSCC).1 However, clinical practice guidelines currently do not cover specific recommendations regarding the management of advanced cSCC with ICB. Hence, we have performed a systematic review on the current use of ICB for advanced cSCC. PMID: 32068244 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 17, 2020 Category: Dermatology Authors: Steeb T, Wessely A, Heppt F, Harlaß M, Berking C, Heppt MV Tags: Br J Dermatol Source Type: research

The European TREatment of ATopic eczema Taskforce (TREAT) Survey; prescribing practices in Europe for phototherapy and systemic therapy in moderate-to-severe adult atopic eczema patients.
CONCLUSIONS: This study provides insight into prescribing practices for conventional photo- and systemic therapies in Europe and shows that off-label therapies are also preferred as first line choice of systemic therapy. PMID: 32068893 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 17, 2020 Category: Dermatology Authors: Vermeulen FM, Gerbens LAA, Schmitt J, Deleuran M, Irvine AD, Logan K, Ouwerkerk W, Vestergaard C, Flohr C, Spuls PI, international TREAT Registry Taskforce Tags: Br J Dermatol Source Type: research

Reliability and validity of the Vitiligo Signs of Activity Score (VSAS).
CONCLUSION: The VSAS appears to be a valid and reliable instrument to score visible clinical signs linked to disease activity in a standardised way. PMID: 32064583 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 15, 2020 Category: Dermatology Authors: van Geel N, Passeron T, Wolkerstorfer A, Speeckaert R, Ezzedine K Tags: Br J Dermatol Source Type: research

The efficacy and safety of topical rapamycin/calcitriol for facial angiofibromas in patients with tuberous sclerosis complex: a prospective, double-blind randomized clinical trial.
Abstract BACKGROUND: The efficacy of topical rapamycin is well-documented for tuberous sclerosis complex (TSC)-related facial angiofibromas (FAs). Calcitriol has been shown to lessen skin fibrosis and may be therapeutically beneficial to FAs. OBJECTIVE: To evaluate if topical rapamycin-calcitriol combination an effective and safe treatment for TSC-related FAs. METHODS: Fifty-two TSC patients with FAs were enrolled in this prospective study including three 12-week periods. In period 1, either topical rapamycin (0.1%) or calcitriol (0.0003%) single-agent therapy versus their combination were applied by a d...
Source: The British Journal of Dermatology - February 15, 2020 Category: Dermatology Authors: Chen PL, Hong JB, Shen LJ, Chen YT, Wang SJ, Liao YH Tags: Br J Dermatol Source Type: research

GNAQ and GNA11 mutant non-uveal melanoma, a subtype distinct from both cutaneous and uveal melanoma.
CONCLUSIONS: Our findings suggest that GNAQ/11 mutant non-uveal melanomas are a melanoma subtype distinct both clinically and genetically from cutaneous and uveal melanoma. As they respond poorly to available treatment regimens, novel effective therapeutic approaches for affected patients are urgently needed. PMID: 32064597 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 15, 2020 Category: Dermatology Authors: Livingstone E, Zaremba A, Horn S, Ugurel S, Casalini B, Schlaak M, Hassel JC, Herbst R, Utikal JS, Weide B, Gutzmer R, Meier F, Koelsche C, Hadaschik E, Sucker A, Reis H, Merkelbach-Bruse S, Siewert M, Sahm F, von Deimling A, Cosgarea I, Zimmer L, Schaden Tags: Br J Dermatol Source Type: research

Incidence of different cancer types in dermatomyositis, polymyositis and dermatopolymyositis: results of a registry analysis.
Abstract Studies confirming Dermatomyositis/polymyositis/dermatopolymyositis (DM/PM/DPM) as a paraneoplastic disease have found cancer incidence rates elevated at the time point of diagnosis and remaining elevated over time. Guidelines promote cancer screening in newly diagnosed myositis patients. Data on the incidence of cancer types in DM/PM patients are insufficient to guide targeted screening. PMID: 32060906 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 13, 2020 Category: Dermatology Authors: Zidane M, Dressler C, Nast A, Egeberg A Tags: Br J Dermatol Source Type: research

Extensive scalp ulcer secondary to delusional infestation treated with antipsychotics and scalp reconstruction.
o MMS PMID: 32052414 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 11, 2020 Category: Dermatology Authors: Pincelli MS, Guimarãres ALM, Milcheski DA, Dwan AJ, Nico MMS Tags: Br J Dermatol Source Type: research

Reading through genetic 'stop signs': a therapeutic strategy in genetic skin disease.
PMID: 32037506 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 8, 2020 Category: Dermatology Authors: Kibbi N, Rajan N Tags: Br J Dermatol Source Type: research

IP-10/CXCR3 axis is associated with HHV-6 reactivation and the development of sequelae in drug reaction with eosinophilia and systemic symptoms.
CONCLUSIONS: Higher plasma IP-10 levels are associated with the development of long-term sequelae in DRESS. Higher IP-10/CXCR3 expression in skin and more abundant CLA+ CXCR3+ CD4+ cells and CLA+ CXCR3+ CD8+ cells were observed in DRESS patients with HHV-6 reactivation. The IP-10/CXCR3 axis is associated with HHV-6 reactivation and development of long-term sequelae in DRESS. PMID: 32037509 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 8, 2020 Category: Dermatology Authors: Yang CW, Cho YT, Hsieh YC, Hsu SH, Chen KL, Chu CY Tags: Br J Dermatol Source Type: research

Declining levels of serum CXCL10 over time are associated with new onset of psoriatic arthritis in patients with psoriasis: A new biomarker?
Abstract BACKGROUND: We previously found that serum levels of C-X-C motif chemokine 10 (CXCL10) decreased after PsA onset. OBJECTIVE: We measured CXCL10 levels over time in psoriasis patients who developed PsA to determine whether the drop in CXCL10 was specific to these patients and further assess its association with PsA development. METHODS: Prospectively followed psoriasis patients without arthritis (psoriasis cutaneous [PsC]) were assessed yearly by rheumatologists for the presence of PsA. PsC patients who developed PsA (converters) were matched to those that did not develop PsA (non-converters) bas...
Source: The British Journal of Dermatology - February 8, 2020 Category: Dermatology Authors: Abji F, Lee K, Math M, Pollock RA, Machhar R, Cook RJ, Chandran V, Gladman DD Tags: Br J Dermatol Source Type: research

Drug survival and post-drug survival of systemic treatments in a national French cohort of children with atopic dermatitis.
We described the IS use (first and second-line) for children with AD in a French retrospective national cohort, by using two survival analyses: 'drug survival' (DS, defined as the duration of treatment) and 'post-drug survival' (PDS, defined as the time between the end of first-line and the beginning of second-line). PMID: 32037515 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 8, 2020 Category: Dermatology Authors: Chambrelan E, Barbarot S, Bekel L, Poizeau F, Mahé E, Puzenat E, Delaunay J, Mallet S, Bessis D, Maruani A, Miquel J, Raison-Peyron N, Abasq C, Phan A, Du Thanh A, Kupfer I, Bonniaud B, Bouzille G, Dupuy A, Droitcourt C, Groupe de Recherche sur l’Eczé Tags: Br J Dermatol Source Type: research

The 2020 IACS Consensus Criteria for the Diagnosis of Scabies.
CONCLUSIONS: The 2020 IACS Criteria represent a pragmatic, yet robust set of diagnostic features and methods. The criteria may be implemented in a range of research, public health and clinical settings by selecting the appropriate diagnostic levels and subcategories. These criteria may provide greater consistency and standardisation for scabies diagnoses. Validation studies and development of training materials and development of survey methods are now required. PMID: 32034956 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 7, 2020 Category: Dermatology Authors: Engelman D, Yoshizumi J, Hay RJ, Osti M, Micali G, Norton S, Walton S, Boralevi F, Bernigaud C, Bowen AC, Chang AY, Chosidow O, Estrada-Chavez G, Feldmeier H, Ishii N, Lacarrubba F, Mahé A, Maurer T, Mahdi MMA, Murdoch ME, Pariser D, Nair PA, Rehmus W, R Tags: Br J Dermatol Source Type: research

Basal cell carcinoma: an emerging epidemic in women in Iceland.
CONCLUSIONS: This is the only reported population in which the incidence of BCC is significantly higher in women than in men. The period of notable increase in BCC lesions correlates with the period of increase in tanning bed and travel popularity. The high multiplicity rates suggest that total tumor burden worldwide might be higher than previously thought. PMID: 32030719 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 6, 2020 Category: Dermatology Authors: Adalsteinsson JA, Ratner D, Olafsdóttir E, Grant-Kels J, Ungar J, Silverberg JI, Kristjansson AK, Jonasson JG, Tryggvadottir L Tags: Br J Dermatol Source Type: research

Racial and Ethnic Disparities in Global Atopic Dermatitis Clinical Trials.
Abstract Atopic dermatitis (AD) is a chronic inflammatory dermatosis affecting up to 20% of children and 3% of adults.1 Historically AD was more prevalent in more developed nations. However, recent trends indicate an increasing prevalence in developing regions, including Southeast Asian countries, Mexico, Chile, Kenya, and Algeria. PMID: 32030728 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 6, 2020 Category: Dermatology Authors: Price KN, Krase JM, Loh TY, Hsiao JL, Shi VY Tags: Br J Dermatol Source Type: research

A feasibility study of microwave therapy for precancerous actinic keratoses.
Abstract BACKGROUND: Actinic keratosis (AK) is a common pre-malignant skin lesion that can progress to cutaneous squamous cell carcinoma (cSCC). Microwave therapy is an established cancer treatment and has been used for plantar viral warts. OBJECTIVES: To evaluate the efficacy and feasibility of microwave as a treatment for AK. METHODS: Stage 1 was a dose-setting study, where seven participants had the dielectric properties of 12 thick and 22 thin AK assessed for optimisation of the microwave dose used for treatment in Stage 2. Stage 2 was a randomised, internally-controlled trial evaluating 179 AK in 11...
Source: The British Journal of Dermatology - February 5, 2020 Category: Dermatology Authors: Jackson DN, Hogarth FJ, Sutherland D, Holmes EM, Donnan PT, Proby CM Tags: Br J Dermatol Source Type: research

Method for the accurate determination of the DNA protection factor of sun protection products.
This study addresses an important issue in skin photoprotection: the prevention of the accumulation of DNA damage. Solar UV radiation is readily absorbed by DNA and triggers the formation of dimeric pyrimidine photoproducts such as cyclobutane pyrimidine dimers (CPDs). One purpose of sun protection products is to decrease the biological consequences of overexposure to sunlight and in particular prevent the formation of mutagenic CPDs1 which play major roles in the initiation of skin tumors. PMID: 32030725 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 5, 2020 Category: Dermatology Authors: Josse G, Gravier E, Douki T Tags: Br J Dermatol Source Type: research

Artificial intelligence in dermatology: the "unsupervised" learning.
Artificial intelligence in dermatology: the "unsupervised" learning. Br J Dermatol. 2020 Feb 06;: Authors: Acharya P, Mathur M Abstract The potential areas of application of artificial intelligence in dermatology are ever-increasing. With the wide availability of smartphones equipped with high-resolution cameras and impressive processing powers, harnessing these capabilities using machine learning (ML) could open new prospects in the management of dermatological disorders. Du-Harpur et al. have done a commendable job reviewing the utility of artificial intelligence in dermatology in an easil...
Source: The British Journal of Dermatology - February 5, 2020 Category: Dermatology Authors: Acharya P, Mathur M Tags: Br J Dermatol Source Type: research

Association of blood mercury levels with nonmelanoma skin cancer in the U.S.A. using National Health and Nutrition Examination Survey data (2003-2016).
CONCLUSIONS: We found that higher blood tHg and MeHg levels were associated with a higher prevalence of NMSC. PMID: 32020585 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 4, 2020 Category: Dermatology Authors: Rhee J, Vance TM, Lim R, Christiani DC, Qureshi AA, Cho E Tags: Br J Dermatol Source Type: research

Validation of Patient-Reported Outcomes Information System Sleep Disturbance and Sleep-Related Impairment in Adults With Atopic Dermatitis.
Abstract BACKGROUND: Sleep disturbances (SD) are common in adults with atopic dermatitis (AD). Patient-Reported Outcomes Measurement Information System (PROMIS™) SD and Sleep-Related Impairment (SRI) are validated questionnaires to assess sleep in adults. Little is known about their measurement properties in adults with AD. OBJECTIVE: To assess the measurement properties of PROMIS SD and SRI 8-item short-forms in AD. METHODS: We performed a prospective dermatology practice-based study using questionnaires and evaluation by a dermatologist (n=420). RESULTS: PROMIS SD/SRI showed moderate correla...
Source: The British Journal of Dermatology - February 3, 2020 Category: Dermatology Authors: Lei D, Yousaf M, Janmohamed SR, Vakharia PP, Chopra R, Sacotte R, Patel KR, Singam V, Immaneni S, Kantor R, Hsu DY, Silverberg JI Tags: Br J Dermatol Source Type: research

Development of a new patient-reported outcome measure to assess activities and participation in people with systemic sclerosis: The Cochin 17-item Scleroderma Functional Scale.
CONCLUSIONS: The CSF-17 is a new patient-reported outcome assessing activities and participation specifically in people with SSc. Its content and construct validities are very good. PMID: 32017013 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 3, 2020 Category: Dermatology Authors: Daste C, Abdoul H, Foissac F, Papelard A, Alami S, Kwakkenbos L, Carrier ME, Lefèvre-Colau MM, Thombs BD, Poiraudeau S, Rannou F, Mouthon L, Nguyen C Tags: Br J Dermatol Source Type: research

Consensus re-classification of inherited epidermolysis bullosa and other disorders with skin fragility.
CONCLUSION: The proposed classification scheme should be of value both to clinicians and researchers, emphasizing both clinical and genetic features of EB. PMID: 32017015 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 3, 2020 Category: Dermatology Authors: Has C, Bauer JW, Bodemer C, Bolling M, Bruckner-Tuderman L, Diem A, Fine JD, Heagerty A, Hovnanian A, Marinkovich P, Martinez AE, McGrath JA, Moss C, Murrell DF, Palisson F, Schwieger-Briel A, Sprecher E, Tamai K, Uitto J, Woodley DT, Zambruno G, Mellerio Tags: Br J Dermatol Source Type: research

Long-term and multiple hospital readmissions after discharge for Stevens-Johnson Syndrome and toxic epidermal necrolysis.
Abstract Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis (TEN) are characterized by blistering and necrosis of skin and mucosa. Hospitalization for SJS/TEN was associated with a short-term (30-day) readmission rate of 10.3%1 . Little is known about longer-term and/or multiple readmissions. PMID: 32017033 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 3, 2020 Category: Dermatology Authors: Cheng BT, Silverberg JI Tags: Br J Dermatol Source Type: research

Light brown structureless areas as predictor of melanoma in situ.
Abstract Although dermoscopic criteria and algorithms have been developed to increase sensitivity and specificity of melanoma diagnosis, the detection of thin melanoma, in particular melanoma in situ (MIS) can still present some difficulties. PMID: 32017037 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 3, 2020 Category: Dermatology Authors: Filoni A, Lospalluti L, Zanframundo G, De Marco A, Argenziano G, Bonamonte D Tags: Br J Dermatol Source Type: research

Healthcare resource utilization and payer cost analysis of patients with prurigo nodularis.
Abstract Prurigo nodularis (PN) is a chronic dermatosis characterized by severely pruritic nodules on the trunk and extensor surfaces. In addition to its skin manifestations, PN is also associated with a variety of systemic conditions.1,2,3 Furthermore, many patients with PN are refractory to therapy with no FDA-approved agents available to date.4 Despite challenges in management and a significant burden of comorbidities in PN, there are limited studies examining healthcare utilization in this condition.5 Herein we use a medical claims from a large, ambulatory cohort to describe real-world healthcare utilization a...
Source: The British Journal of Dermatology - February 3, 2020 Category: Dermatology Authors: Huang AH, Canner JK, Williams KA, Grossberg AL, Kwatra MM, Kwatra SG Tags: Br J Dermatol Source Type: research

Three-dimensional neuroanatomy of the intra-epidermal nervous system.
Abstract Intra-epidermal nerve fibers (IENFs) are presumed to comprise mainly of itch-transmitting nerve fibers, and variations in their density have been studied in itch disorders; epidermal nerve fiber density is also a criterion in diagnosing small fiber neuropathy in clinical neurological practice. IENFs are typically identified with 2-dimensional (2D) histological slides, but 2D sections do not accurately represent nerves, which branch out in three-dimensions (3D). PMID: 32017051 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 3, 2020 Category: Dermatology Authors: Tan Y, Ning ZY, Yu X, Kwong BLT, Ng LG, Tey HL Tags: Br J Dermatol Source Type: research

Phenotype and function of circulating memory T cells 1 in human vitiligo.
CONCLUSIONS: The decreased frequency of circulating Th1/Tc1, Th17/Tc17 and Th1/Th17-70 Tc1/Tc17 cells suggests a possible migration of these T cell subsets into the skin of patients that could be targeted to prevent the flare of the disease. PMID: 32012221 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 2, 2020 Category: Dermatology Authors: Martins C, Darrigade AS, Jacquemin C, Barnetche T, Taieb A, Ezzedine K, Boniface K, Seneschal J Tags: Br J Dermatol Source Type: research

Who dies from thin melanoma?
PMID: 32017009 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 2, 2020 Category: Dermatology Authors: Cust AE Tags: Br J Dermatol Source Type: research

Measuring what's important to adolescents with psoriasis.
PMID: 32017024 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 2, 2020 Category: Dermatology Authors: Blome C Tags: Br J Dermatol Source Type: research

Secukinumab in patients with psoriasis who have responded inadequately to tumour necrosis factor inhibitor treatment.
PMID: 32017027 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 2, 2020 Category: Dermatology Authors: Tsai TF Tags: Br J Dermatol Source Type: research

Broadening indications for neoadjuvant immunotherapy.
PMID: 32017031 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 2, 2020 Category: Dermatology Authors: Blankenstein SA, van Akkooi ACJ Tags: Br J Dermatol Source Type: research

Among the brightest antipsoriatic stars.
PMID: 32017032 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 2, 2020 Category: Dermatology Authors: Meier K, Ghoreschi K Tags: Br J Dermatol Source Type: research

Does the gene matter? Genotype-phenotype and genotype-outcome associations in congenital melanocytic naevi.
Abstract Congenital melanocytic naevi (CMNs, commonly known as "moles") are made up of pigment cells which contain a gene that has undergone an alteration (mutation). We know that different moles have different genetic mutations (or "genotypes"), and also that different moles look and behave differently, that is they have different "phenotypes". Very rarely a CMN can be linked with problems in the brain or can even develop into a malignant tumour (melanoma). These researchers in London reviewed 156 CMNs from 134 children to see whether specific genotypes cause particular phenotypes. T...
Source: The British Journal of Dermatology - January 31, 2020 Category: Dermatology Authors: Polubothu S, McGuire N, Al-Olabi L, Baird W, Bulstrode N, Chalker J, Josifova D, Lomas D, O'Hara J, Ong J, Rampling D, Stadnik P, Thomas A, Wedgeworth E, Sebire NJ, Kinsler VA Tags: Br J Dermatol Source Type: research

Dermoscopy in general dermatology: a 'Delphinitive' step forward.
PMID: 32017017 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 31, 2020 Category: Dermatology Authors: Bahadoran P Tags: Br J Dermatol Source Type: research

The road to real-time, bedside, optical imaging pathology: basal cell carcinoma and beyond.
PMID: 32017020 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 31, 2020 Category: Dermatology Authors: Navarrete-Dechent C, Marghoob AA, Chen CJ Tags: Br J Dermatol Source Type: research

Facets of shame are differently expressed in dermatological disease: A prospective observational study.
Abstract The recent years have witnessed a growing interest in clinical research on the experience of shame and its associations with psychological functioning and well-being. Shame is a self-regulatory function of the body in adapting to the social environment as well as maintaining and restoring self-esteem and self-acceptance. PMID: 31997342 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 29, 2020 Category: Dermatology Authors: Aberer E, Hiebler-Ragger M, Zenker M, Weger W, Hofer A, Unterrainer HF Tags: Br J Dermatol Source Type: research

Commentary: Ligelizumab for chronic spontaneous urticaria.
Abstract Chronic spontaneous urticaria (CSU) is a very disabling condition. It can be difficult to treat. Less than 50% of people respond to licenced dosages of H1-antihistamines (though up-dosing where safe increases the response rate). Additionally, only a small proportion respond to the addition of the leukotriene receptor antagonist (LTRA) montelukast.1,2. PMID: 32002982 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 29, 2020 Category: Dermatology Authors: Sabroe RA Tags: Br J Dermatol Source Type: research

A novel approach to understanding potential risk factors for venous leg ulceration.
PMID: 32002984 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 29, 2020 Category: Dermatology Authors: Magin P Tags: Br J Dermatol Source Type: research

Real-world data for direct stage-specific costs of melanoma healthcare.
Abstract In Europe, melanoma is the fourth most common cancer diagnosed in young adults (20 to 45 years old) [1]. It also has one of the fastest-growing incidence rates globally, and this trend is expected to continue in all European countries [2]. Thus, also due to the costly new treatment options available, the economic burden of this illness is expected to keep increasing as well [3]. PMID: 31997306 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 28, 2020 Category: Dermatology Authors: Buja A, Rivera M, De Polo A, Zorzi M, Carpin E, Vecchiato A, Del Fiore P, Martin G, Saia M, Baldo V, Rugge M, Rossi CR Tags: Br J Dermatol Source Type: research

Eczema and water hardness: another piece of the puzzle found?
PMID: 31994183 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 28, 2020 Category: Dermatology Authors: Arents BWM, Leonardi-Bee J Tags: Br J Dermatol Source Type: research