Dominant dystrophic epidermolysis bullosa is associated with glycolytically active GATA3+ Th2 cells which may contribute to pruritus in lesional skin

CONCLUSIONS: Single-cell RNA-seq helps define an enhanced DDEB-associated Th2 profile and rationalizes drug repurposing of anti-Th2 drugs in treating DDEB pruritus.PMID:38477474 | DOI:10.1093/bjd/ljae110

Source: The British Journal of Dermatology - March 13, 2024 Category: Dermatology Authors: Wilson Jr F Aala Ping-Chen Hou Yi-Kai Hong Yu-Chen Lin Yu-Rong Lee Wei-Ting Tu Marieta Papanikolaou Natashia Benzian-Olsson Alexandros Onoufriadis Hans I-Chen Harn Daw-Yang Hwang Siao Muk Cheng Kurt Lu Peng-Chieh Chen John A McGrath Chao-Kai Hsu Source Type: research