All aboard the BJD for global dissemination of high-quality dermatology clinical practice guidelines.
PMID: 32613650 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 1, 2020 Category: Dermatology Authors: Yiu ZZN, Chi CC, Flohr C Tags: Br J Dermatol Source Type: research

A viral rash: the impact of COVID-19 infection on the skin.
PMID: 32613651 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 1, 2020 Category: Dermatology Authors: Hay RJ Tags: Br J Dermatol Source Type: research

Gingival telangiectasia of dermatomyositis.
PMID: 32608029 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 30, 2020 Category: Dermatology Authors: Milani-Nejad N, Kaffenberger J Tags: Br J Dermatol Source Type: research

Global Hidradenitis Suppurativa COVID-19 Registry: A Registry to Inform Data-Driven Management Practices.
Abstract The management of hidradenitis suppurativa (HS), a chronic inflammatory skin disease, deserves special consideration in the context of the Coronavirus 2019 (COVID-19) pandemic. A new Global Hidradenitis Suppurativa COVID-19 Registry has been developed to capture data on risks, clinical course, and outcomes of COVID-19 in HS patients. Caused by the virus SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), COVID-19 is an easily transmissible disease which, in its most severe form, is characterized by respiratory failure and multiple organ dysfunction triggered by a cytokine storm response that pre...
Source: The British Journal of Dermatology - June 29, 2020 Category: Dermatology Authors: Naik HB, Alhusayen R, Frew J, Guilbault S, Ingram JR, Lowes MA, Marzano AV, Paul M, Villumsen B, Yannuzzi CA Tags: Br J Dermatol Source Type: research

A 10-year Review of Surgical Management of Dermatofibrosarcoma Protuberans.
CONCLUSIONS: WLE was the commonest surgical modality used to treat DFSP across the UK. The local recurrence rate was very low, occurring only after WLE. Although a prospective RCT may provide more definitive outcomes, in the absence of a clearly superior surgical modality, treatment decisions should be based on patient preference, clinical expertise and cost. PMID: 32599647 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 29, 2020 Category: Dermatology Authors: Durack A, Gran S, Gardiner MD, Jain A, Craythorne E, Proby CM, Marsden J, Harwood CA, Matin RN, DFSP Collaborators Tags: Br J Dermatol Source Type: research

Validation of Patient Global Item for Quality of Life Impact on Hidradenitis Suppurativa.
Abstract BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease that is not well understood. The HS core outcome set calls for a patient global assessment (PtGA), for which measures are limited. OBJECTIVES: Our aim is to assess the validity, reliability, and responsiveness of a candidate single-item PtGA for HS-specific health-related quality of life (HRQOL). METHODS: Cognitive debriefing interviews were conducted with HS patients in Denmark (DK) and the United States (US). Field testing was conducted via a cross-sectional observational study with adults with HS in the US and DK. The...
Source: The British Journal of Dermatology - June 29, 2020 Category: Dermatology Authors: Kirby JS, Hereford B, Thorlacius L, Villumsen B, Ingram JR, Garg A, Butt M, Esmann S, King T, Tan J, Jemec GBE Tags: Br J Dermatol Source Type: research

Doppler Ultrasound-Based Non-Invasive Biomarkers in Hidradenitis Suppurativa: Evaluation of Analytical and Clinical Validity.
CONCLUSIONS: Sonographic epidermal thickness and dermal tunnel diameter have acceptable levels of analytical validity in the assessment of HS lesions. Power Doppler intensity demonstrates acceptable clinical and analytical validity suggesting it is a valid imaging-based biomarker in HS. PMID: 32602132 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 29, 2020 Category: Dermatology Authors: Grand D, Frew JW, Navrazhina K, Krueger JG Tags: Br J Dermatol Source Type: research

Development and efficacy of a nested real-time quantitative polymerase chain reaction to identify the cytochrome c oxidase subunit 1 gene of Sarcoptes scabiei var. hominis for diagnosis and monitoring of ordinary scabies.
Abstract Dear Editor, Scabies infestation is increasingly a public health concern, even in high-income countries. The disability-adjusted life-years (DALYs) globally was estimated to be 71·11 (95% CI 39·77-116·03) per 100,000 people based on the results of a cross-sectional analysis from the Global Burden of Disease Study 20158 . The gold standard for scabies diagnosis is microscopic examination of skin scrapings in mineral oil, but the sensitivity of this technique is low3 ; as a result, scabies infestation cannot be ruled out even when this test is negative. PMID: 32594512 [PubMed - as ...
Source: The British Journal of Dermatology - June 28, 2020 Category: Dermatology Authors: Kim JK, Chun EJ, Yang SY, Kim KS, Kim SS, Kim CW Tags: Br J Dermatol Source Type: research

Efficacy and safety of risankizumab vs. secukinumab in patients with moderate-to-severe plaque psoriasis (IMMerge): Results from a phase 3, randomised, open-label, efficacy assessor-blinded clinical trial.
Abstract BACKGROUND: Patients with plaque psoriasis treated with biologic therapies need more efficacious, safe, and convenient treatments to improve quality of life. Risankizumab and secukinumab inhibit interleukin (IL)-23 and IL-17A, respectively, and are effective in adult patients with moderate-to-severe plaque psoriasis but have different dosing regimens. OBJECTIVES: Directly compare efficacy and safety of risankizumab vs. secukinumab over 52 weeks. METHODS: IMMerge was an international, phase 3, multicentre, open-label, efficacy assessor-blinded, active-comparator study, in which adult patients wit...
Source: The British Journal of Dermatology - June 28, 2020 Category: Dermatology Authors: Warren RB, Blauvelt A, Poulin Y, Beeck S, Kelly M, Wu T, Geng Z, Paul C Tags: Br J Dermatol Source Type: research

Mutations in genes encoding desmosomal proteins: spectrum of cutaneous and extracutaneous abnormalities.
Abstract The desmosome is a type of intercellular junction found in epithelial cells, cardiomyocytes and other specialised cell types. Composed of a network of transmembranous cadherins and intracellular armadillo, plakin and other proteins, desmosomes contribute to cell-cell adhesion, signalling, development and differentiation. Mutations in genes encoding desmosomal proteins result in a spectrum of erosive skin and mucosal phenotypes that also may affect hair or heart. This review summarises the molecular pathology and phenotypes associated with desmosomal dysfunction with a focus on inherited disorders that inv...
Source: The British Journal of Dermatology - June 27, 2020 Category: Dermatology Authors: Lee JYW, McGrath JA Tags: Br J Dermatol Source Type: research

Dermatological signs lead to discovery of mosaic ACTB variants in segmental odonto-maxillary dysplasia.
Abstract Segmental odontomaxillary dysplasia (SOD) is a rare condition of unknown incidence, with approximately 60 cases reported (as reviewed in 2018)1 . It presents at birth or during childhood with a constellation of ipsilateral facial signs: non-progressive/slowly-progressive overgrowth or undergrowth of soft tissues and/or bones (typically centred on the posterior maxilla, and leading to facial asymmetry), dental anomalies (missing teeth or abnormal dentition), gingival hyperplasia or abnormal gingivae, commissural lip fissures, hypertrichosis, cutaneous hyperpigmentation and/or erythema, cutaneous depression...
Source: The British Journal of Dermatology - June 25, 2020 Category: Dermatology Authors: Polubothu S, Abdin D, Barysch M, Thomas A, Bulstrode N, Evans R, Solman L, Obwegeser J, Hennekam RC, Weibel L, Calder A, Di Donato N, Kinsler VA Tags: Br J Dermatol Source Type: research

COVID-19 chilblain-like lesion: immunohistochemical demonstration of SARS-CoV-2 spike protein in blood vessel endothelium and sweat gland epithelium in a PCR-negative patient.
, Requena L Abstract A 35-year-old woman with no significant previous medical history presented at the Emergency Department of Fundación Jiménez Díaz Hospital (Madrid, Spain) on April 14th with acral purpuric lesions of three weeks duration. These had started as oedematous, erythematous areas and had appeared coincidentally with fever and coughing, which lasted only two days. There was no history of diarrhoea, ageusia, hyposmia or dyspnea. The patient stated that the skin of her feet acquired a bluish discoloration after standing for some time. PMID: 32585767 [PubMed - as supplied by publ...
Source: The British Journal of Dermatology - June 25, 2020 Category: Dermatology Authors: Santonja C, Heras F, Núñez L, Requena L Tags: Br J Dermatol Source Type: research

Epigastric cutaneous discharge: think amoebiasis.
lot M PMID: 32588425 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 25, 2020 Category: Dermatology Authors: Merad Y, Behague L, Valot S, Basmaciyan L, Dalle F, Estève C, Catherine FX, Blot M Tags: Br J Dermatol Source Type: research

Basaloid follicular proliferations, brain tumours and SUFU.
PMID: 32588433 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 25, 2020 Category: Dermatology Authors: Manam S, Oliphant T, Husain A, Rajan N Tags: Br J Dermatol Source Type: research

Suspension of marketing authorisation for ingenol mebutate.
Abstract The authors of the British Association of Dermatologists' (BAD) clinical guidelines for managing actinic keratosis and the BAD's Therapy & Guidelines sub-committee wish to notify readers of the 2017 guideline publication that the marketing authorisation for ingenol mebutate has been suspended by the United Kingdom's Medicines and Healthcare products Regulatory Agency (MHRA) on 27th January 2020. This is due to emerging evidence suggesting possible links between use of the product with an increased risk of developing skin cancers. The manufacturers are recalling all stocks of this medication. Further a...
Source: The British Journal of Dermatology - June 24, 2020 Category: Dermatology Authors: Mohd Mustapa MF, de Berker D, McGregor JM, Exton LS, Hughes BR, Levell NJ Tags: Br J Dermatol Source Type: research

Efficacy and safety of topical resorcinol 15% as long-term treatment of mild-moderate hidradenitis suppurativa: a valid alternative to clindamycin in the panorama of antibiotic resistance.
Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory disease that affects the hair follicle in the apocrine gland-bearing regions. Although HS is not primarily caused by bacterial infection, antibiotics represent the first line treatment in the management of HS primarily for their anti-inflammatory properties, with additional contributions via antimicrobial and immunomodulatory effects. PMID: 32579711 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 24, 2020 Category: Dermatology Authors: Molinelli E, Brisigotti V, Simonetti O, Campanati A, Sapigni C, D'Agostino GM, Giacchetti A, Cota C, Offidani A Tags: Br J Dermatol Source Type: research

Should we be imaging lymph nodes at initial diagnosis of early-stage mycosis fungoides? Results from the PROCLIPI international Study.
CONCLUSION: Physical examination was a poor determinant of LN enlargement/involvement. Presence of plaques was associated with significant increase in identification of enlarged/involved LN in patients with early-stage presentation of MF, which may be important when deciding who to image. Imaging increases detection rate of stage-IIA, and identifies rare cases of extensive lymphomatous nodes, upstaging them to advanced-stage IVA2. PMID: 32574377 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 23, 2020 Category: Dermatology Authors: Hodak E, Sherman S, Papadavid E, Bagot M, Querfeld C, Quaglino P, Prince HM, Ortiz-Romero PL, Stadler R, Knobler R, Guenova E, Estrach T, Patsatsi A, Leshem YA, Prague-Naveh H, Berti E, Alberti-Violetti S, Cowan R, Jonak C, Nikolaou V, Mitteldorf C, Akilo Tags: Br J Dermatol Source Type: research

QuantiFERON TB-gold  conversion is not uncommon in psoriasis patients under anti-TNF-α: reply from author.
QuantiFERON TB-gold conversion is not uncommon in psoriasis patients under anti-TNF-α: reply from author. Br J Dermatol. 2020 Jun 22;: Authors: Fernandez AP Abstract We thank Megna et al. for their interest in our article. However, we respectfully disagree that annual QFT testing should be adopted for every psoriasis patient treated with TNF-α inhibitors (TNFIs). To optimize the risk:benefit ratio of any screening test, it is important to define a high-risk subgroup1 . For example, annual lung cancer screening is not recommended in all smokers, but specifically older smokers who have ...
Source: The British Journal of Dermatology - June 22, 2020 Category: Dermatology Authors: Fernandez AP Tags: Br J Dermatol Source Type: research

Sars-CoV-2 infection: the same virus can cause different cutaneous manifestations: reply from authors.
G, Garcia-Doval I Abstract Dr Drago et al. are right to point out that our paper did not provide data on enanthems1,2 . As the data collection form did not include the description of mucous membranes, they might have not been explored in many patients. We have reported and included in the supplementary material a few cases that were noticed by their doctors and were the first descriptions of enanthem in COVID-19. Given the low number of cases and their non-systematic acquisition, we avoided any analysis of these data. PMID: 32569387 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 22, 2020 Category: Dermatology Authors: Galván-Casas C, Catalá A, Carretero Hernández G, Garcia-Doval I Tags: Br J Dermatol Source Type: research

Systemic treatment in atopic dermatitis after 2018: from experienced-based treatment to evidence-based treatment?
PMID: 32567048 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 21, 2020 Category: Dermatology Authors: de Bruin-Weller M Tags: Br J Dermatol Source Type: research

What should be in the facial patch testing series for 2020?
PMID: 32567050 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 21, 2020 Category: Dermatology Authors: Boonchai W Tags: Br J Dermatol Source Type: research

Innovative devices for actinic keratoses: a hot-button issue.
PMID: 32567062 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 21, 2020 Category: Dermatology Authors: Samimi M, Kelleners-Smeets N Tags: Br J Dermatol Source Type: research

External validation of a model to predict risk of keratinocyte skin cancer after a renal transplantation in a Western European cohort.
Abstract Renal transplant recipients (RTRs) face an increased risk of developing keratinocyte skin cancer (KSC) due to their lifelong immunosuppressive drug use. Current recommendations call for 6- to 12-monthly skin examinations for all RTRs. To develop a more personalized screening procedure, Urwin, et al identified the most significant KSC risk factors in an Australian sample and developed a predictive index (PI) that stratifies patients into high-, medium- and low-risk groups. We have externally validated this PI and evaluated its geographic transportability to The Netherlands. PMID: 32562548 [PubMed - as...
Source: The British Journal of Dermatology - June 20, 2020 Category: Dermatology Authors: Verhage EJ, Nelemans PJ, van Kuijk SMJ, Christiaans MHL, Kelleners-Smeets NWJ Tags: Br J Dermatol Source Type: research

Co-inheritance of Naevoid Basal Cell Carcinoma Syndrome and Neurofibromatosis Type 1 associated with an exceptional spectrum of tumours.
Abstract The tumours arising in naevoid basal cell carcinoma syndrome (NBCCS) and neurofibromatosis type 1 (NF1) are distinct, and are exemplars of the specific consequences of mutations arising in different tumour suppressor genes. Whilst each syndrome has recognised pathognomonic tumours, an exceptional spectrum of tumours presenting in an individual with either syndrome may represent the interaction of an additional tumour suppressor gene. PMID: 32562549 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 20, 2020 Category: Dermatology Authors: Ghadiri SJ, Brennan P, Calonje E, Carmichael AJ, Rajan N Tags: Br J Dermatol Source Type: research

Comparing the efficacy and tolerability of biologic therapies in psoriasis: an updated network meta-analysis.
CONCLUSIONS: Using our methodology, we find most biologics cluster together with respect to short-term efficacy and tolerability, and we do not identify any single agent as 'best'. These data need to be interpreted in the context of longer-term efficacy, effectiveness data, safety, posology, and drug acquisition costs when making treatment decisions. PMID: 32562551 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 20, 2020 Category: Dermatology Authors: Mahil SK, Ezejimofor MC, Exton LS, Manounah L, Burden AD, Coates LC, de Brito M, McGuire A, Murphy R, Owen CM, Parslew R, Woolf RT, Yiu ZZN, Uthman OA, Mohd Mustapa MF, Smith CH Tags: Br J Dermatol Source Type: research

SARS-CoV-2 endothelial infection causes COVID-19 chilblains: histopathological, immunohistochemical and ultraestructural study of 7 paediatric cases.
CONCLUSIONS: Although the clinical and histopathological features were similar to other forms of chilblains, the presence of viral particles in the endothelium and the histological evidence of vascular damage, support a causal relation of the lesions with SARS-CoV-2. Endothelial damage induced by the virus could be the key mechanism in the pathogenesis of COVID-19 chilblains and perhaps also in a group of patients severely affected by COVID-19 presenting with features of microangiopathic damage. PMID: 32562567 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 20, 2020 Category: Dermatology Authors: Colmenero I, Santonja C, Alonso-Riaño M, Noguera-Morel L, Hernández-Martín A, Andina D, Wiesner T, Rodríguez-Peralto JL, Requena L, Torrelo A Tags: Br J Dermatol Source Type: research

SARS-CoV-2 infection: the same virus can cause different cutaneous manifestations: reply from the authors.
, García-Doval I Abstract Drago et al. are right to point out that our paper did not provide data on enanthems.1,2 As the data collection form did not include the description of mucous membranes, they might not have been explored in many patients. We have reported and included in the supplementary material a few cases that were noticed by their doctors and were the first descriptions of enanthem in COVID-19. Given the low number of cases and their nonsystematic acquisition, we avoided any analysis of these data. PMID: 32557597 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 17, 2020 Category: Dermatology Authors: Galván Casas C, Català A, Carretero Hernández G, García-Doval I Tags: Br J Dermatol Source Type: research

The incidence of bullous pemphigoid continues to increase in England.
PMID: 32538459 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 15, 2020 Category: Dermatology Authors: Bax CE, Werth VP Tags: Br J Dermatol Source Type: research

Survival is excellent for most patients with thin melanoma, but patients may die from thin melanoma.
PMID: 32538460 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 15, 2020 Category: Dermatology Authors: Hollestein LM, Nijsten T Tags: Br J Dermatol Source Type: research

Risk of infections in psoriasis. A lesson to learn during the SARS-CoV-2 pandemic.
PMID: 32538461 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 15, 2020 Category: Dermatology Authors: Naldi L Tags: Br J Dermatol Source Type: research

Tinea incognito infection with Trichophyton erinacei from a pet hedgehog.
PMID: 32538462 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 15, 2020 Category: Dermatology Authors: Yin B, Ran X, Zhang C, Xie Z, Ran Y, Fu L, Pradhan S Tags: Br J Dermatol Source Type: research

A new self-reported measure of disease severity of scalp hair loss in alopecia areata.
PMID: 32538464 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 15, 2020 Category: Dermatology Authors: Rencz F Tags: Br J Dermatol Source Type: research

Limited effectiveness of four oral antifungal drugs (fluconazole, griseofulvin, itraconazole and terbinafine) in the current epidemic of altered dermatophytosis in India: results of a randomized pragmatic trial.
Abstract BACKGROUND: Dermatophytic infections have undergone unprecedented changes in India in the recent past. Clinical trials to find out the effectiveness of the four main oral antifungal drugs are lacking. OBJECTIVES: We tested the effectiveness of oral fluconazole, griseofulvin, itraconazole and terbinafine in chronic and chronic relapsing tinea corporis, tinea cruris and tinea faciei in an investigator-initiated, randomized, pragmatic trial. METHODS: Two hundred patients with microscopy-confirmed tinea were allocated to four groups (50 patients in each group): fluconazole 5 mg kg-1 per day, griseof...
Source: The British Journal of Dermatology - June 15, 2020 Category: Dermatology Authors: Singh S, Chandra U, Anchan VN, Verma P, Tilak R Tags: Br J Dermatol Source Type: research

How to measure itch in atopic dermatitis?
PMID: 32538467 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 15, 2020 Category: Dermatology Authors: Oosterhaven JAF Tags: Br J Dermatol Source Type: research

Sars-CoV-2 infection: the same virus can cause different cutaneous manifestations.
Abstract The article of Galván Casas et al. describing the cutaneous manifestations occurring during the COVID-19 pandemic1 prompted us to make some observations. Informations regarding the prevalence of enanthems, their clinical features and the association with exanthem patterns and disease severity are lacking. In the absence of a clearly defined temporal connection, the relationship between exanthems and SARS-CoV-2 infection is at times unclear, as in the case of urticarial/maculopapular eruptions in patients undergoing treatment with multiple drugs. PMID: 32533844 [PubMed - as supplied by publishe...
Source: The British Journal of Dermatology - June 13, 2020 Category: Dermatology Authors: Drago F, Ciccarese G, Rebora A, Muzic SI, Parodi A Tags: Br J Dermatol Source Type: research

Bacterial and fungal microbiome characterization in patients with rosacea and healthy controls.
Abstract Rosacea is a common inflammatory skin disease, but its pathophysiology is still unclear. Several microorganisms, including Cutibacterium acnes, Demodex spp. and Staphylococcus epidermidis, have been suggested to play roles in its pathogenesis. However, it is suspected that the community of microorganisms in and on the skin, rather than a single species, plays a more causative role in the disease. Our study aims to characterize and compare the skin bacterial and fungal microbiome in rosacea patients and healthy controls. PMID: 32533846 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 13, 2020 Category: Dermatology Authors: Wang R, Farhat M, Na J, Li R, Wu Y Tags: Br J Dermatol Source Type: research

Diagnostic and Therapeutic Differences Between Immune Checkpoint Inhibitor-Induced and Idiopathic Bullous Pemphigoid: A Cross-Sectional Study.
Abstract Bullous pemphigoid (BP) is a serious, rare complication from immune checkpoint inhibitors (ICIs). While most dermatologic immune-related adverse events (irAEs) present early and are mild, ICI-induced BP (ICI-BP) manifests months into therapy and can prompt ICI discontinuation and severe immunosuppression. Following irAE management guidelines, providers rely on systemic corticosteroids - which, at high doses, may confer poorer oncologic outcomes for ICI patients. Our study aims to identify diagnostic and therapeutic differences between ICI-BP and idiopathic BP (iBP) to assist providers in prompt recognitio...
Source: The British Journal of Dermatology - June 12, 2020 Category: Dermatology Authors: Molina GE, Reynolds KL, Chen ST Tags: Br J Dermatol Source Type: research

Long-Term Safety of Certolizumab Pegol in Plaque Psoriasis: Pooled Analysis over 3 Years from Three Phase 3, Randomised, Placebo-Controlled Studies.
CONCLUSIONS: No new safety signals were identified compared to previously reported data. Risk did not increase with longer or higher CZP exposure. PMID: 32531798 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 12, 2020 Category: Dermatology Authors: Blauvelt A, Paul C, van de Kerkhof P, Warren RB, Gottlieb AB, Langley RG, Brock F, Arendt C, Boehnlein M, Lebwohl M, Reich K Tags: Br J Dermatol Source Type: research

Views and experiences of managing eczema: systematic review and thematic synthesis of qualitative studies.
CONCLUSIONS: Effective self-management of eczema could be supported by addressing beliefs and concerns about treatments; seeking positive ways to promote a 'control not cure' message; acknowledging psychosocial impacts of eczema and treatment burden; and providing clear consistent advice or signposting towards reliable information. PMID: 32531800 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 12, 2020 Category: Dermatology Authors: Teasdale E, Muller I, Sivyer K, Ghio D, Greenwell K, Wilczynska S, Roberts A, Ridd MJ, Francis N, Yardley L, Thomas KS, Santer M Tags: Br J Dermatol Source Type: research

QuantiFERON TB-gold conversion is not uncommon in psoriasis patients under anti-TNF- α.
QuantiFERON TB-gold conversion is not uncommon in psoriasis patients under anti-TNF-α. Br J Dermatol. 2020 Jun 12;: Authors: Megna M, Ruggiero A, Ferrillo M, Fabbrocini G Abstract Tuberculosis (TB) screening and eventual TB infection prophylaxis in case of screening positivity for latent TB infection (LTBI) are mandatory before starting a biologic treatment for psoriasis.1 Indeed, opportunistic infections reactivation, especially LTBI, is one the main risk during biologic therapy, in particular with tumour necrosis factor (TNF)-α inhibitors. It is already known that TNFα plays a majo...
Source: The British Journal of Dermatology - June 12, 2020 Category: Dermatology Authors: Megna M, Ruggiero A, Ferrillo M, Fabbrocini G Tags: Br J Dermatol Source Type: research

Clinical predictive factors of unresponsiveness to omalizumab in patients with chronic spontaneous urticaria.
ard F Abstract Chronic spontaneous urticaria (CSU) is an inflammatory disease which is characterized by spontaneous appearance of wheals (hives), angioedema or both for at least six weeks. Approximately 10% of patients suffering from CSU are unresponsive to second-generation H1-antihistamines. For these severe cases, recommendation is a treatment by omalizumab (OMZ) -a humanized anti-IgE monoclonal antibody. However, approximately 20% of patients are still non-responders to OMZ. PMID: 32531805 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 12, 2020 Category: Dermatology Authors: Castagna J, Bernard L, Hacard F, Delcroix F, Darrigade AS, Nicolas JF, Decullier E, Nosbaum A, Bérard F Tags: Br J Dermatol Source Type: research

Burnout in psychodermatology: results from a European survey.
Abstract Burnout is defined as a work-induced syndrome combining emotional exhaustion, depersonalisation and a sense of reduced personal accomplishment. Maslach et al. was the first to provide the definition of burnout as 'a long term, unresolvable stress that leads to exhaustion and feeling overwhelmed, cynical, detached from the job and lacking a sense of personal accomplishment'. PMID: 32526067 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 11, 2020 Category: Dermatology Authors: Gkini MA, Hussain K, Taylor R, Bewley A Tags: Br J Dermatol Source Type: research

What are the barriers to physical activity in patients with chronic plaque psoriasis?
PMID: 32524578 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 10, 2020 Category: Dermatology Authors: Jarrett P Tags: Br J Dermatol Source Type: research

Biologics for psoriasis: what does drug survival tell us?
PMID: 32524579 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 10, 2020 Category: Dermatology Authors: Veysey E Tags: Br J Dermatol Source Type: research

Current measures are not sufficient: an interview-based qualitative assessment of quality of life in cutaneous T-cell lymphoma.
CONCLUSIONS: Incorporating these concerns and priorities that distinguish CTCL patients from other patient populations will be of paramount importance in developing a comprehensive CTCL-specific measure of QoL that adequately captures patients' experience. PMID: 32510571 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 8, 2020 Category: Dermatology Authors: Bhat TS, Herbosa CM, Rosenberg AR, Sogade O, Jeffe DB, Mehta-Shah N, Semenov YR, Musiek AC Tags: Br J Dermatol Source Type: research

What has changed in the UK management of hidradenitis suppurativa from 2014 to 2019?
Abstract A previous survey demonstrated the management of hidradenitis suppurativa (HS) in the UK in 2014 and subsequently, in 2018, the first UK guidelines for the management of HS were published.2 We recently repeated the survey to evaluate whether there has been a change in the management of HS influenced by the guidelines and new HS treatment evidence. PMID: 32510572 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 8, 2020 Category: Dermatology Authors: Hasan SB, Ingram JR Tags: Br J Dermatol Source Type: research

Hyperhidrosis Quality of Life Index (HidroQoL ©): further validation and clinical application in patients with axillary hyperhidrosis using data from a phase III RCT.
Hyperhidrosis Quality of Life Index (HidroQoL©): further validation and clinical application in patients with axillary hyperhidrosis using data from a phase III RCT. Br J Dermatol. 2020 Jun 08;: Authors: Gabes M, Jourdan C, Schramm K, Masur C, Abels C, Kamudoni P, Salek S, Apfelbacher C Abstract BACKGROUND: The Hyperhidrosis Quality of Life Index (HidroQoL©) is a validated patient-reported outcome measure capturing the quality of life of people affected by hyperhidrosis. We aimed to extend the validity evidence to physician-confirmed diagnosis of primary axillary hyperhidrosis. METHODS:...
Source: The British Journal of Dermatology - June 8, 2020 Category: Dermatology Authors: Gabes M, Jourdan C, Schramm K, Masur C, Abels C, Kamudoni P, Salek S, Apfelbacher C Tags: Br J Dermatol Source Type: research

Treatment persistence in paediatric and adolescent psoriasis patients followed into young adulthood: from topical to systemic treatment - a prospective, longitudinal, observational cohort study of 448 patients.
CONCLUSIONS: In a population of paediatric and adolescent psoriasis patients with mild to severe psoriasis, a third needs more intensive treatment than solely topical therapy to control their disease. We consider median time until switch to systemic to be long. PMID: 32510578 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 8, 2020 Category: Dermatology Authors: Bruins FM, Bronckers IMGJ, Cai R, Groenewoud HMM, Krol M, de Jong EMGJ, Seyger MMB Tags: Br J Dermatol Source Type: research

Outcomes for Pressure Ulcer Trials (OUTPUTs) project: review and classification of outcomes reported in pressure ulcer prevention research.
CONCLUSION: A plethora of different outcomes is applied in pressure ulcer prevention research and substantial variations in definitions and reporting of similar outcomes were observed. A COS for pressure ulcer prevention trials is needed to overcome the non-comparability of outcomes. PMID: 32510579 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 8, 2020 Category: Dermatology Authors: Lechner A, Kottner J, Coleman S, Muir D, Beeckman D, Chaboyer W, Cuddigan J, Moore Z, Rutherford C, Schmitt J, Nixon J, Balzer K Tags: Br J Dermatol Source Type: research

Global trends in melanoma mortality differ by sex and age.
PMID: 32515011 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 8, 2020 Category: Dermatology Authors: Olsen CM Tags: Br J Dermatol Source Type: research