Oral clindamycin and rifampicin in the treatment of hidradenitis suppurativa-acne inverse in paediatric age: a pilot, prospective study.
Abstract Hidradenitis suppurativa-acne inversa (HS-AI) is a chronic, inflammatory, recurrent, debilitating skin disease of the terminal hair follicle that usually presents with painful, deep-seated, inflamed lesions in the apocrine-gland-bearing areas of the body.The disease typically occurs in the second and third decade of life but an early onset, in paediatric age (0-16 years), is reported in 2% to 8.1% of patients. PMID: 33544882 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 5, 2021 Category: Dermatology Authors: Bettoli V, Toni G, Odorici G, Forconi R, Corazza M Tags: Br J Dermatol Source Type: research

Five-year efficacy and safety of tildrakizumab in patients with moderate to severe psoriasis who respond at week 28: pooled analyses of two randomised phase 3 clinical trials (reSURFACE 1 and reSURFACE 2).
We present 5-year pooled data from reSURFACE 1 and reSURFACE 2. METHODS: reSURFACE 1 and reSURFACE 2 were double-blind, randomised, controlled studies with optional long-term extensions. Adults with moderate-to-severe chronic plaque psoriasis were randomised 2:2:1 to tildrakizumab 100 (TIL100) or 200 mg (TIL200) or placebo at weeks 0 and 4, and every 12 weeks thereafter (reSURFACE 2 included an etanercept arm). Efficacy outcomes included proportions of patients achieving absolute and relative improvement from baseline Psoriasis Area and Severity Index (PASI) score through week 244 in tildrakizumab responders (≥75% ...
Source: The British Journal of Dermatology - February 5, 2021 Category: Dermatology Authors: Thaçi D, Piaserico S, Warren RB, Gupta AK, Cantrell W, Draelos Z, Foley P, Igarashi A, Langley RG, Asahina A, Young M, Falqués M, Pau-Charles I, Mendelsohn AM, Rozzo SJ, Reich K Tags: Br J Dermatol Source Type: research

Exploring the melanoma survivorship experience: a qualitative study.
Abstract Cutaneous melanomas are the fifth most common cancer in the United States and the United Kingdom, with a 5-year relative survival of 87-93%.1,2 Targeted and immune checkpoint therapies have further expanded the number of advanced melanoma survivors. Cancer survivorship recommendations have been published by Macmillan Cancer Support; yet programs for melanoma survivors in the US are still in their infancy.3 We aimed to explore experiences and challenges that US patients diagnosed with melanoma experienced in a tertiary cancer centre using in-depth interviews. PMID: 33544884 [PubMed - as supplied by pu...
Source: The British Journal of Dermatology - February 5, 2021 Category: Dermatology Authors: Wolner ZJ, Flowers NI, Yushak ML, Chen SC, Yeung H Tags: Br J Dermatol Source Type: research

Trends in opioid prescribing at outpatient visits for psoriasis and psoriatic arthritis.
The objective of this study was to examine trends in opioid prescribing at outpatient visits for psoriasis and PsA in the United States (US). PMID: 33544885 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 5, 2021 Category: Dermatology Authors: Taylor MT, Noe MH, Horton DB, Barbieri JS Tags: Br J Dermatol Source Type: research

Drug survival of Adalimumab and Infliximab in Hidradenitis Suppurativa Patients: A Daily Practice Cohort Study.
ns EP Abstract BACKGROUND: Biologics are often required for treatment of hidradenitis suppurativa (HS). However, data on the drug survival of biologics in daily practice are currently lacking. OBJECTIVES: To assess the drug survival of anti-TNF biologics in a daily practice cohort of HS patients and to identify predictors for drug survival. METHODS: A retrospective multicenter study was performed in two academic dermatology centers in The Netherlands. Adult HS patients using biologics between 2008 and 2020 were included. Drug survival was analyzed using Kaplan Meier survival curves, predictors of surviva...
Source: The British Journal of Dermatology - February 5, 2021 Category: Dermatology Authors: Prens LM, Bouwman K, Aarts P, Arends S, van Straalen KR, Dudink K, Horváth B, Prens EP Tags: Br J Dermatol Source Type: research

Somatostatin receptors: an alternative treatment target for advanced Merkel cell carcinoma.
Authors: Abstract Merkel cell carcinoma (MCC) is a rare but aggressive skin cancer with a high risk of returning and spreading. It affects about 2500 new patients every year in the USA. Current effective treatments for advanced MCC include immunotherapy and chemotherapy. Immunotherapy helps a patient's immune system fight against cancer, but only half of MCC patients have long-term benefit. Chemotherapy works initially, but the cancer starts growing again after an average of 90 days. Moreover, chemotherapy can cause severe side-effects. Therefore, we need newer treatments for advanced MCC. Somatostatin analogues ...
Source: The British Journal of Dermatology - February 1, 2021 Category: Dermatology Tags: Br J Dermatol Source Type: research

Putting the burden of skin diseases on the global map.
PMID: 33544440 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 1, 2021 Category: Dermatology Authors: Flohr C, Hay R Tags: Br J Dermatol Source Type: research

Obituary: Vale Robert Alan Briggaman MD 1934-2020.
PMID: 33544442 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 1, 2021 Category: Dermatology Authors: Murrell DF, Cheesborough J, Woodley DT Tags: Br J Dermatol Source Type: research

Evidence for efficacy of home-based narrowband ultraviolet B therapy.
PMID: 33523459 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 1, 2021 Category: Dermatology Authors: Wolkerstorfer A Tags: Br J Dermatol Source Type: research

Using electronic health records to examine links between atopic dermatitis and obesity.
PMID: 33523463 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 1, 2021 Category: Dermatology Authors: Lucas JA Tags: Br J Dermatol Source Type: research

New insights on treatment utilization and outcomes in early-stage mycosis fungoides.
PMID: 33523469 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 1, 2021 Category: Dermatology Authors: Porcu P, Nikbakht N Tags: Br J Dermatol Source Type: research

Telescope punch biopsy of normal-appearing skin to diagnose intravascular lymphoma.
PMID: 33523506 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 1, 2021 Category: Dermatology Authors: Winge MCG, Iberri DJ, Novoa RA, Kwong BY, Zaba LC Tags: Br J Dermatol Source Type: research

Diagnosing Atopic Dermatitis in Infancy Using Established Diagnostic Criteria: A Cohort Study.
CONCLUSION: The UKWP and H&R criteria for AD used in combination and at multiple time points may be useful in clinical research, but may have limited value in most other clinical settings. PMID: 33511639 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 28, 2021 Category: Dermatology Authors: Endre KMA, Landrø L, LeBlanc M, Gjersvik P, Lødrup Carlsen KC, Haugen G, Hedlin G, Jonassen CM, Nordlund B, Rudi K, Skjerven HO, Staff AC, Söderhäll C, Vettukattil R, Rehbinder EM Tags: Br J Dermatol Source Type: research

Perceived psychological stress and risk of herpes zoster: a nationwide population-based cohort study.
ard M Abstract BACKGROUND: Psychological stress may reduce cellular immunity, but its role in triggering latent infections, including herpes zoster (HZ), is controversial. OBJECTIVES: To examine the association between perceived psychological stress and risk of HZ. METHODS: In a linked registry-based cohort study, we followed 77,310 persons aged 40 years or older who participated in the 2010 Danish National Health Survey from May 1, 2010 until HZ diagnosis, death, emigration, or July 1, 2014, whichever occurred first. We computed hazard ratios (HRs) of HZ associated with Cohen's Perceived Stress Scale (P...
Source: The British Journal of Dermatology - January 28, 2021 Category: Dermatology Authors: Schmidt SAJ, Sørensen HT, Langan SM, Vestergaard M Tags: Br J Dermatol Source Type: research

SARS-CoV-2 Spike Protein Positivity in Pityriasis Rosea-like and Urticaria-like Rashes of COVID-19.
Abstract The spike (S) protein of SARS-CoV-2 is responsible for receptor recognition and cell membrane fusion.1 Positive immunohistochemistry (IHC) for SARS-CoV/SARS-CoV-2 spike protein has been found in lungs, tracheal mucosa, renal tubular epithelial cells, and recently in chilblain-like and erythema multiforme-like lesions of patients with COVID-19.2 Herein, we report on two patients, one with a pityriasis rosea-like rash, and one with an urticarial rash with positive IHC for SARS-CoV/SARS-CoV-2 spike protein. PMID: 33511657 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 28, 2021 Category: Dermatology Authors: Welsh E, Cardenas-de la Garza JA, Cuellar-Barboza A, Franco-Marquez R, Arvizu-Rivera RI Tags: Br J Dermatol Source Type: research

Pain Index: A new prospective hidradenitis suppurativa patient-reported outcome measure instrument.
Abstract Hidradenitis suppurativa/acne inversa (HS) is a painful disease.1,2 Pain, drainage and itching are the symptoms, which HS patients consider of playing a central role in the reduction of their quality of life. Pain could be classified in two types, a nociceptive, acute skin pain, which correlates well with the severity of skin lesions,3,4 and a chronic central sensitization, which some patients call pain, and is associated with their overall performance not only due to HS.5,6. PMID: 33492666 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 25, 2021 Category: Dermatology Authors: Zouboulis CC Tags: Br J Dermatol Source Type: research

Most rare subtypes of cutaneous lymphoma display variable CD30 expression. Analysis of the German Cutaneous Lymphoma Network.
Abstract CD30, also known as tumor necrosis factor receptor 8 (TNF-R 8), was primarily called Ki-1 and is a cell surface molecule which has first been described from a group of pathologists from Kiel in 1982.1 CD30 can be targeted with the drug brentuximab-vedotin (BV), which is approved for relapsed or refractory CD30+ cutaneous T-cell lymphoma (CTCL) including primary cutaneous anaplastic large cell lymphoma and CD30+ mycosis fungoides and Sézary syndrome. PMID: 33480069 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 22, 2021 Category: Dermatology Authors: Wehkamp U, Mitteldorf C, Stendel S, Stranzenbach R, Nicolay JP, Wobser M, Weichenthal M, Schneiderbauer R, Klemke CD, Hillen U, Kempf W, Assaf C Tags: Br J Dermatol Source Type: research

Association of Disease Characteristics with the Temporal Sequence of Skin and Musculoskeletal Disease Onset in Psoriatic Arthritis.
n MA, Gonullu E, Yildiz F, Esmen SE, Kucuk A, Tufan A, Balkarli A, Mercan R, Yazisiz V, Erten S, Akar S, Aksu K, Aydin SZ, Kalyoncu U Abstract The temporal relationship between the onset of skin psoriasis (Pso) and psoriatic arthritis (PsA) is a long and well-known feature of psoriatic disease. Psoriatic skin lesions emerge years before the development of musculoskeletal manifestations in nearly 75% of PsA patients. While skin and joint manifestations develop within one year in 15-20% of the patients, joint manifestations precede the skin involvement by a year or more in about 10% of the patients (1). PMID: 3...
Source: The British Journal of Dermatology - January 22, 2021 Category: Dermatology Authors: Tascilar K, Bayindir O, Dogru A, Tinazzi I, Kimyon G, Ozisler C, Erden A, Dalkilic E, Cetin GY, Yılmaz S, Solmaz D, Bakirci S, Omma A, Kasifoglu T, Kucuksahin O, Cinar M, Kilic L, Can M, Tarhan EF, Bilgin E, Ersozlu ED, Duruoz T, Yavuz S, Pehlevan S, Tuf Tags: Br J Dermatol Source Type: research

Linear and disseminated porokeratosis in one family showing identical and independent second hits in MVD among skin lesions, respectively: A proof of concept study.
Abstract Porokeratosis is an autosomal dominant skin disorder characterized by annular or circular skin lesions surrounded by a hyperkeratotic rim called "cornoid lamella".1 Clinical subtypes of porokeratosis have been classified mostly based on age at onset, and the distribution and size of skin lesions.1 It has been demonstrated that most patients with porokeratosis have a heterozygous germline mutation in genes that encode enzymes of the mevalonate pathway, MVK, MVD, PMVK, or FDPS, in both familial and sporadic cases. PMID: 33481264 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 22, 2021 Category: Dermatology Authors: Shiiya C, Aoki S, Nakabayashi K, Hata K, Amagai M, Kubo A Tags: Br J Dermatol Source Type: research

The risk of systemic infections requiring hospitalisation in children with atopic dermatitis: a Danish retrospective nationwide cohort study.
CONCLUSIONS: Children with hospital-managed AD have an increased risk of systemic infections that lead to hospitalization. The absolute risk was generally low. PMID: 33476408 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 21, 2021 Category: Dermatology Authors: Droitcourt C, Vittrup I, Dupuy A, Egeberg A, Thyssen JP Tags: Br J Dermatol Source Type: research

Hair stylists as Screeners for Scarring Hair Loss within the African American Community: A Cross Sectional Study.
Abstract Scarring alopecia is a common cause of hair loss in African American women, of which subtype Central Centrifugal Cicatricial Alopecia (CCCA) is the most frequent culprit.1 Both genetic predisposition and environmental factors play critical roles in CCCA development.2 CCCA progresses gradually, and patients may not seek medical attention before blatant alopecia occurs. Treatment focuses on preventing further hair loss and promoting regrowth in non-permanently scarred areas using topical, intralesional, or oral therapies. PMID: 33459357 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 18, 2021 Category: Dermatology Authors: Veerabagu SA, Lauth MJ, Obayomi A, Correa M, Murina AT Tags: Br J Dermatol Source Type: research

Black in the ivory.
Abstract To be Black in the United States is to be a minority in almost every context, including in medicine. I will be part of the 2% of physicians who are Black women in a country where 13.4% of the population is Black. I am a medical student by day and an activist by night. As a Black woman in this country, activism feels mandatory. My life could depend on it. PMID: 33454967 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 17, 2021 Category: Dermatology Authors: Ngonadi N Tags: Br J Dermatol Source Type: research

Association between hospital-diagnosed atopic dermatitis and psychiatric disorders and medication use in childhood.
CONCLUSIONS: The increased risk of treatment, but not of hospital-diagnosis of psychiatric disorders in children with hospital-diagnosed AD, suggests that psychiatric issues in children with AD could be of transient, reversible or mild-moderate nature. PMID: 33454962 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 16, 2021 Category: Dermatology Authors: Vittrup I, Andersen YMF, Droitcourt C, Skov L, Egeberg A, Fenton MC, Mina-Osorio P, Boklage S, Thyssen JP Tags: Br J Dermatol Source Type: research

Hand Eczema in Children Referred for Patch Testing: North American Contact Dermatitis Group Data, 2000-2016.
Abstract BACKGROUND: Little is known about the etiologies and relevant allergens in pediatric patients with hand eczema (HE). OBJECTIVE: To characterize the etiologies and determine proportion of positive and currently relevant allergens in children/adolescents (age
Source: The British Journal of Dermatology - January 16, 2021 Category: Dermatology Authors: Silverberg JI, Warshaw EM, Maibach HI, DeKoven JG, Taylor JS, Atwater AR, Sasseville D, Zug KA, Reeder MJ, Fowler JF, Pratt MD, Fransway AF, Zirwas MJ, Belsito DV, Marks JG, DeLeo VA Tags: Br J Dermatol Source Type: research

Oral ivermectin for a scabies outbreak in a long-term-care facility: Potential value in preventing COVID-19 and associated mortality?
Abstract To-date, COVID-19 pandemic affected>85 million persons worldwide with 14% severe and 5% critical, and a general population case-fatality rate of 1%. Age is the main risk factor for severe disease and death1 making the long-term-care facilities (LTCFs) residents particularly vulnerable.2 COVID-19 therapeutic agents remain sparce and ivermectin, an antiparasitic showed anti-SARS-CoV-2 activity in vitro.3 Moxidectin, another macrocyclic lactone, with a longer plasma half-life, could be considered too. PMID: 33454964 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 16, 2021 Category: Dermatology Authors: Bernigaud C, Guillemot D, Ahmed-Belkacem A, Grimaldi-Bensouda L, Lespine A, Berry F, Softic L, Chenost C, Do-Pham G, Giraudeau B, Fourati S, Chosidow O Tags: Br J Dermatol Source Type: research

A multicenter study of nevus-associated melanoma versus de novo melanoma, tumor thickness and body site differences.
CONCLUSIONS: Clinicopathological and body site differences between de novo melanoma and NAM support divergent pathways of development. These differences were also found in thin melanomas, suggesting that de novo melanomas are different from NAM and their differences are not due to the obliteration of nevus remnants in thicker tumors. PMID: 33454993 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 16, 2021 Category: Dermatology Authors: Dessinioti C, Geller AC, Stergiopoulou A, Dimou N, Lo S, Keim U, Gershenwald JE, Haydu LE, Dummer R, Mangana J, Hauschild A, Egberts F, Vieira R, Brinca A, Zalaudek I, Deinlein T, Evangelou E, Thompson JF, Scolyer RA, Peris K, Garbe C, Stratigos AJ Tags: Br J Dermatol Source Type: research

Identification of compound heterozygous mutations in AP1B1 leading to the newly-described recessive keratitis-ichthyosis-deafness (KIDAR) syndrome.
scher J Abstract Recently, mutations in Adaptor Related Protein Complex 1 Subunit Beta 1 (AP1B1) have been identified as the cause of a new form of syndromic ichthyosis, which is characterized by neonatal onset of ichthyosis, erythroderma and deafness accompanied by failure to thrive and developmental delay.(1,2) In adulthood, keratitis has been diagnosed as well.(1) Based on the observed phenotype and the autosomal-recessive mode of inheritance, the disease has been classified as a keratitis-ichthyosis-deafness syndrome (KIDAR; OMIM:242150). In this letter, we describe an additional case of KIDAR caused by AP1B1 ...
Source: The British Journal of Dermatology - January 16, 2021 Category: Dermatology Authors: Vornweg J, Gläser S, Ahmad-Anwar M, Zimmer AD, Kuhn M, Hörer S, Korenke GC, Grothaus J, Ott H, Fischer J Tags: Br J Dermatol Source Type: research

Minimal, superficial DNA damage in human skin from filtered far-ultraviolet-C (UV-C).
Abstract Krypton-Chloride (Kr-Cl) excimer lamps have a peak emission wavelength of 222 nm in the ultraviolet-C (UV-C) region of the electromagnetic spectrum. Currently Kr-Cl lamps are the only viable "far-UV-C" sources for full-room inactivation of airborne SARS-CoV-2, the virus responsible for the COVID-19 pandemic1 . Commercially available Kr-Cl excimer lamps can be retro-fitted to existing room lamp fittings or mounted at ceiling height independently. Other technologies, such as light emitting diodes (LEDs), are currently neither efficient nor powerful enough for such a task. PMID: 33452809 [PubM...
Source: The British Journal of Dermatology - January 16, 2021 Category: Dermatology Authors: Hickerson RP, Conneely MJ, Tsutsumi SKH, Wood K, Jackson DN, Ibbotson SH, Eadie E Tags: Br J Dermatol Source Type: research

Agminated benign vascular tumor successfully treated with Trametinib.
Abstract Vascular tumours are caused by the neoplastic transformation of cells constituting vascular structures. Traditionally, treatment options include surgical approaches such as resection, embolization/sclerotherapy, or laser therapy, and medical treatments such as corticosteroids, beta-blockers, and chemotherapy. The investigation of genetic mutations underlying vascular anomalies has recently provided new insights into the genetic aetiology of these lesions,1 giving rise to personalized, targeted medical treatment that may potentially be safer and more effective. Here, we describe a patient who presented wit...
Source: The British Journal of Dermatology - January 16, 2021 Category: Dermatology Authors: Greenberger S, Stein R, Ollech A, Hartstein ME, Benyamini O, Yalon M, Levi A, Lapidoth M, Barzilai A Tags: Br J Dermatol Source Type: research

Relationship between type 2 diabetes mellitus and markers of cutaneous melanoma aggressiveness: An observational multi-centric study in 443 patients with melanoma.
CONCLUSIONS: T2DM, rather than glycaemic control and metformin treatment, is associated with increased cutaneous melanoma aggressiveness at diagnosis. PMID: 33453061 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 16, 2021 Category: Dermatology Authors: Nagore E, Martinez-Garcia MA, Gomez-Olivas JD, Manrique-Silva E, Martorell A, Bañuls J, Carrera C, Ortiz P, Gardeazabal J, Boada A, de Eusebio E, Chiner E, Gonzalez C, Pérez-Gil A, Cullen D, Formigón M, de Unamuno B, Navarro-Soriano C, Muriel A, Gozal Tags: Br J Dermatol Source Type: research

Interventions for basal cell carcinoma: abridged Cochrane systematic review and grade assessments.
CONCLUSIONS: Surgical interventions have lower recurrence rates and remain the gold-standard for high-risk BCC. Of the non-surgical treatments, topical imiquimod has the best evidence to support its efficacy for low-risk BCC. Priorities for future research include agreement on core outcome measures and studies with longer follow-up. PMID: 33448328 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 15, 2021 Category: Dermatology Authors: Thomson J, Hogan S, Leonardi-Bee J, Williams HC, Bath-Hextall FJ Tags: Br J Dermatol Source Type: research

Development or exacerbation of hidradenitis suppurativa in two transgender men after initiation of testosterone therapy.
Abstract Transgender individuals are a growing patient population with unique dermatologic needs. Masculinizing hormone therapy (MHT) involves the use of exogenous testosterone to promote masculine and suppress feminine secondary sex characteristics.1 Commonly reported cutaneous effects of MHT include acne vulgaris and androgenic alopecia.2 To our knowledge, there have been no reported cases of hidradenitis suppurativa (HS) among transgender patients receiving MHT. Herein we present two patients, one that developed HS and one with worsening HS symptoms after initiating MHT. PMID: 33448331 [PubMed - as supplie...
Source: The British Journal of Dermatology - January 15, 2021 Category: Dermatology Authors: Buonomo M, Mansh MD, Thorpe D, Goldfarb N Tags: Br J Dermatol Source Type: research

Clinical Photography in Skin of Color: Tips and Best Practices.
Abstract High quality photos are critical to dermatology: both for clinical care and education. Although best practices for capturing skin photos have been outlined,1 these omit specific challenges of taking photos of dark skin. Bias against accurate capture of dark skin in photographic technology is a longstanding issue2 . Film photography colour balance relied on reference cards portraying white models2 , and digital photography still has issues capturing detailed photos of darker skin. PMID: 33448346 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 15, 2021 Category: Dermatology Authors: Lester JC, Clark L, Linos E, Daneshjou R Tags: Br J Dermatol Source Type: research

A 1% glycopyrronium bromide cream for the topical treatment of primary axillary hyperhidrosis: Efficacy and Safety Results from a Phase 3a Randomised Controlled Study.
CONCLUSION: 1% GPB cream may provide an effective new treatment option exhibiting a good safety profile for patients with primary axillary hyperhidrosis. The long-term open-label part (Phase 3b) is ongoing. PMID: 33445205 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 14, 2021 Category: Dermatology Authors: Abels C, Soeberdt M, Kilic A, Reich H, Knie U, Jourdan C, Schramm K, Heimstaedt-Muskett S, Masur C, Szeimies RM Tags: Br J Dermatol Source Type: research

Inducible skin-associated lymphoid tissue (iSALT) in a patient with Schnitzler syndrome who manifested wheals on recurrent localized erythema.
Abstract Schnitzler syndrome is characterized by a chronic urticarial rash with an intermittent fever, and is considered to be an acquired form of autoinflammatory syndrome because its clinical phenotypes are similar to cryopyrin-associated periodic syndrome with a gain-of-function mutation in NLRP3.1 Patients with Schnitzler syndrome also exhibit IgM monoclonal gammopathy, and 15-20% of patients eventually develop a lymphoproliferative disorder resembling Waldenström macroglobulinemia with an MYD88 mutation.2 At present, the precise pathogenesis of Schnitzler syndrome remains unknown. PMID: 33445206 [Pu...
Source: The British Journal of Dermatology - January 14, 2021 Category: Dermatology Authors: Kamido H, Shimomiya D, Kogame T, Takimoto-Ito R, Kataoka TR, Hirata M, Ueshima C, Otsuka A, Ghazawi FM, Nomura T, Kambe N, Kabashima K Tags: Br J Dermatol Source Type: research

Diagnostic value of cutaneous manifestation of SARS-CoV-2 infection.
CONCLUSIONS: Skin rashes cluster with other COVID-19 symptoms, are predictive of a positive swab test, and occur in a significant number of cases, either alone or before other classical symptoms. Recognising rashes is important in identifying new and earlier COVID-19 cases. PMID: 33448030 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 14, 2021 Category: Dermatology Authors: Visconti A, Bataille V, Rossi N, Kluk J, Murphy R, Puig S, Nambi R, Bowyer RCE, Murray B, Bournot A, Wolf J, Ourselin S, Steves CJ, Spector TD, Falchi M Tags: Br J Dermatol Source Type: research

Revolutionizing Atopic Dermatitis, 13-14 December 2020.
Authors: PMID: 33432586 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 11, 2021 Category: Dermatology Tags: Br J Dermatol Source Type: research

Differential Profiles of Gamma-Secretase-Notch Signaling in Hidradenitis Suppurativa: The Need for Genotype-Endotype-Phenotype Analysis.
Abstract Hidradenitis Suppurativa (HS) is a chronic inflammatory dermatosis in which a subset of patients display genetic variants in components of the gamma secretase complex1 proposed to result in dysregulation of Notch signaling2 . This pathogenic paradigm has been highly influential in providing a succinct explanation for the pathogenesis of HS, however the molecular data supporting the hypothesis has been relatively sparse, and largely derived from East Asian populations3,4 . The incidence of Gamma-Secretase associated polymorphisms been demonstrated to be significantly lower in Caucasian populations5 , imply...
Source: The British Journal of Dermatology - January 9, 2021 Category: Dermatology Authors: Frew JW Tags: Br J Dermatol Source Type: research

COVID-19-associated cutaneous manifestations: does HHV-6 play an etiological role?
;a M, Gilaberte Y Abstract Recently, during the development of COVID-19 pandemic, several publications have warned of possible cutaneous manifestations in association with this novel coronavirus (SARS-CoV-2). In our hospital we have created a multidisciplinary unit with a specific protocol to attend patients with these manifestations. Inclusion criteria consisted of patients who, during the development of the pandemic, were clinically suspected and/or microbiologically confirmed of COVID-19 and had a recent-onset skin rash (within the last 4 weeks). All patients underwent biochemistry, hematimetry and serology for...
Source: The British Journal of Dermatology - January 8, 2021 Category: Dermatology Authors: Abadías-Granado I, Navarro-Bielsa A, Morales-Callaghan AM, Roc L, Suso-Estívalez CC, Povar-Echeverría M, Gilaberte Y Tags: Br J Dermatol Source Type: research

COVID-19 related dermatosis in November 2019. Could this case be Italy's patient zero?
tti E Abstract Milan, the largest city in northern Italy, was one of the first European metropolitan areas to be affected by the COVID-19 pandemic. We analyzed skin biopsies of patients from Milan with dermatoses and positive PCR swabs for SARS-CoV-2 at different stages of the infection (1,2). The results were compared to skin biopsies of 20 COVID-19 non-diagnosed patients with dermatoses, who were at high-risk of COVID-19 infection. PMID: 33410129 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 7, 2021 Category: Dermatology Authors: Gianotti R, Barberis M, Fellegara G, Galván-Casas C, Gianotti E Tags: Br J Dermatol Source Type: research

Obstructive Sleep Apnea in Psoriasis and Hidradenitis Suppurativa.
Abstract Obstructive sleep apnoea (OSA) is an independent risk factor for the development of cardiovascular disease. Epidemiological studies report that the prevalence of OSA in psoriasis patients (1) and in hidradenitis suppurativa (HS) patients is higher than healthy control populations. (2) This is the first prospective study to use formal sleep studies to assess the prevalence of OSA in HS. PMID: 33404093 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 6, 2021 Category: Dermatology Authors: Kelly A, Meurling J, Kirthi Jeyarajah S, Ryan C, Hughes R, Garvey J, Kirby B Tags: Br J Dermatol Source Type: research

Cellulitis in chronic oedema of the lower leg: an international cross-sectional study.
CONCLUSIONS: Cellulitis in chronic leg oedema is a global problem. Several risk factors for cellulitis were identified, of which some are potentially preventable. Our findings suggest that oedema control, is one of these. We also identified that advanced stages of oedema, with hard/fibrotic tissue, might be an important clinical indicator to identify patients at particular risk. PMID: 33405247 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 6, 2021 Category: Dermatology Authors: Burian EA, Karlsmark T, Franks PJ, Keeley V, Quéré I, Moffatt CJ Tags: Br J Dermatol Source Type: research

Targeting the expression of T antigens with Selinexor (KPT-330) shows promise for MCPyV-positive Merkel cell carcinoma treatment.
Abstract Merkel cell carcinoma (MCC) is a rare primary neuroendocrine skin cancer. In the Northern hemisphere, the disease most commonly arises as a result of infection with Merkel cell polyomavirus (MCPyV).1 Although the incidence of MCC is only 0.7 per 100,000 individuals in the United States, this number is increasing worldwide, and the cancer is highly aggressive, often carrying a poor prognosis.2 Immunotherapies such as pembrolizumab have emerged as leading treatments for MCPyV-associated MCC; however, only a subset of patients respond to these agents, and many require other treatments to remain in remission....
Source: The British Journal of Dermatology - January 5, 2021 Category: Dermatology Authors: Gupta R, Simonette RA, Doan HQ, Rady PL, Tyring SK Tags: Br J Dermatol Source Type: research

Huriez syndrome caused by a large deletion that abrogates the skin-specific isoform of SMARCAD1.
Abstract Huriez syndrome (HRZ ; MIM181600) is a rare autosomal dominant genodermatosis, which is characterised by scleroatrophy of the hands and feet, hypoplasia of the nails and palmoplantar keratoderma1,2 . Approximately 15% of HRZ patients are predisposed to cutaneous squamous cell carcinoma (cSCC) which occurs in affected scleroatrophic skin at an early age of 30 to 40 years. cSCC in HRZ may be aggressive, with metastasis and death reported3 . PMID: 33400266 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 5, 2021 Category: Dermatology Authors: Loh AYT, Ho CM, Muthiah S, Venkatesh B, Zwolinski S, Bray APJJ, Reversade B, Rajan N, Carney TJ Tags: Br J Dermatol Source Type: research

Activity and components of the G-CSF pathway in hidradenitis suppurativa.
CONCLUSIONS: The G-CSF pathway engages both tissue and immune cells, is strongly activated in HS lesions, and offers the opportunity to target the neutrophil-driven inflammation. PMID: 33400270 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 5, 2021 Category: Dermatology Authors: Wolk K, Brembach TC, Šimaitė D, Bartnik E, Cucinotta S, Pokrywka A, Irmer ML, Triebus J, Witte-Händel E, Salinas G, Leeuw T, Volk HD, Ghoreschi K, Sabat R Tags: Br J Dermatol Source Type: research

Image guided lymph node core needle biopsy predicts survival in mycosis fungoides and S ézary syndrome.
CONCLUSIONS: CNB allows an objective assessment of the LN involvement in MF/SS, relevant for staging and prognosis. PMID: 33400272 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 5, 2021 Category: Dermatology Authors: Calvani J, de Masson A, de Margerie-Mellon C, de Kerviler É, Ram-Wolff C, Gruber A, Meignin V, Brice P, Sadoux A, Mourah S, Bagot M, Battistella M Tags: Br J Dermatol Source Type: research

Modular gene analysis reveals distinct molecular signatures for cutaneous lupus patient subsets.
CONCLUSION: Our data support a diverse molecular profile in CLE that further adds to the clinical variations of this skin disease, and may affect disease course and treatment selection. Future studies with a larger and diverse CLE patient cohort are warranted to confirm these findings. PMID: 33400293 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 5, 2021 Category: Dermatology Authors: Zhu JL, Tran LT, Smith M, Zheng F, Cai L, James JA, Guthridge JM, Chong BF Tags: Br J Dermatol Source Type: research

Opsin 5 is a key regulator of ultraviolet radiation induced melanogenesis in human epidermal melanocytes.
CONCLUSION: Our results provide insight into the molecular mechanisms of UVR in melanocytes and may reveal molecular targets for preventing pigmentation or pigment diseases. PMID: 33400324 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 5, 2021 Category: Dermatology Authors: Lan Y, Zeng W, Dong X, Lu H Tags: Br J Dermatol Source Type: research

Recommended core outcome instruments for health-related quality of life, long-term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting.
CONCLUSIONS: For now, the core outcome set for clinical trials in AE is complete. The specified domains and instruments should be used in all new clinical trials and systematic reviews of eczema treatments. PMID: 33393074 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - January 4, 2021 Category: Dermatology Authors: Thomas KS, Apfelbacher CA, Chalmers JR, Simpson E, Spuls PI, Gerbens LAA, Williams HC, Schmitt J, Gabes M, Howells L, Stuart BL, Grinich E, Pawlitschek T, Burton T, Howie L, Gadkari A, Eckert L, Ebata T, Boers M, Saeki H, Nakahara T, Katoh N Tags: Br J Dermatol Source Type: research

Cutaneous immune-related adverse events in patients with melanoma treated with checkpoint inhibitors.
Abstract Checkpoint inhibitor (CPI) therapy has vastly improved long-term outcomes in metastatic malignant melanoma (MMM). Therapy takes the form of monoclonal antibody infusions that target immune cell checkpoint proteins, such as cytotoxic T-lymphocyte-associated protein 4 (CTLA4) and programmed death 1/programmed death ligand 1 (PD1/PDL1). Cutaneous immune-related adverse effects (IrAEs) are frequent in patients with MMM treated with CPIs. Our aim was to review the clinical presentations of cutaneous IrAEs associated with CPI therapy in adult patients with MMM. We carried out a literature review of clinical tri...
Source: The British Journal of Dermatology - January 4, 2021 Category: Dermatology Authors: Gault A, Anderson AE, Plummer R, Stewart C, Pratt AG, Rajan N Tags: Br J Dermatol Source Type: research