Improving prognosis for early-stage Merkel cell carcinoma: trends from 1981-2014.
This article is protected by copyright. All rights reserved. PMID: 31483861 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 4, 2019 Category: Dermatology Authors: Cheraghlou S, Agogo GO, Girardi M Tags: Br J Dermatol Source Type: research

Juvenile onset Pustular Psoriasis: Case Series and Literature Review.
Abstract Loss-of-function mutations in IL-36 receptor antagonist, IL36RN, were identified in many cases of generalized pustular psoriasis (GPP). We evaluated the clinical features and IL36RN mutation of all consecutive patients with juvenile-onset pustular psoriasis (onset
Source: The British Journal of Dermatology - September 4, 2019 Category: Dermatology Authors: Huang YW, Tsai TF Tags: Br J Dermatol Source Type: research

Putting nodule counts behind us: hidradenitis suppurativa outcome measures independent of descriptive semantics.
PMID: 31486069 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 4, 2019 Category: Dermatology Authors: Frew JW Tags: Br J Dermatol Source Type: research

Tumour serine proteases C1r and C1s as novel biomarkers and therapeutic targets in invasive sporadic and recessive dystrophic epidermolysis bullosa-associated cutaneous squamous cell carcinoma.
PMID: 31486079 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 4, 2019 Category: Dermatology Authors: Kopecki Z Tags: Br J Dermatol Source Type: research

Image Gallery: Green moss-like psoriasis.
PMID: 31475350 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 2, 2019 Category: Dermatology Authors: Rongioletti F, Mugheddu C Tags: Br J Dermatol Source Type: research

Health-related quality of life in cutaneous T-cell lymphoma: examining all sides of the issue.
PMID: 31475351 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 2, 2019 Category: Dermatology Authors: Rosenthal JM, Kim EJ Tags: Br J Dermatol Source Type: research

Corrigendum.
Authors: PMID: 31475339 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2019 Category: Dermatology Tags: Br J Dermatol Source Type: research

Keeping an eye on the ocular problems in dupilumab clinical trials.
PMID: 31475340 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2019 Category: Dermatology Authors: Chu CY Tags: Br J Dermatol Source Type: research

Serum biomarkers in extramammary Paget disease.
PMID: 31475341 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2019 Category: Dermatology Authors: Ellis R Tags: Br J Dermatol Source Type: research

Keratinocyte cancer incurs a sizeable and almost entirely preventable health burden in the U.K.
PMID: 31475343 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2019 Category: Dermatology Authors: Whiteman DC Tags: Br J Dermatol Source Type: research

Obituary: Professor Marcel F. Jonkman: 1957-2019.
en PM PMID: 31475344 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2019 Category: Dermatology Authors: Horváth B, Bolling MC, Steijlen PM Tags: Br J Dermatol Source Type: research

Pragmatic trials: lab meets bedside.
PMID: 31475345 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2019 Category: Dermatology Authors: Kirtschig G, Lo S, Batchelor J, Clinical Trials Editorial Team of the British Journal of Dermatology Tags: Br J Dermatol Source Type: research

Enduring support for the case report.
PMID: 31475346 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2019 Category: Dermatology Authors: Mellerio JE Tags: Br J Dermatol Source Type: research

Corrigendum.
Authors: PMID: 31475347 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2019 Category: Dermatology Tags: Br J Dermatol Source Type: research

Advances in acute exanthemas.
PMID: 31475349 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2019 Category: Dermatology Authors: Shearer SM, Milani-Nejad N, Kaffenberger BH Tags: Br J Dermatol Source Type: research

Removing the mystery of mite isolation - opening up scabies diagnosis?
PMID: 31475354 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2019 Category: Dermatology Authors: Chandler DJ, Fuller LC Tags: Br J Dermatol Source Type: research

Efficacy and safety of topical delgocitinib in patients with chronic hand eczema: data from a randomised, double-blind, vehicle-controlled Phase 2a study.
CONCLUSIONS: In this proof-of-concept study in CHE, delgocitinib ointment was efficacious and well tolerated. As a plateau of efficacy was not observed, a longer treatment period may lead to increased efficacy. Further clinical studies are warranted to confirm these findings in patients with CHE. This article is protected by copyright. All rights reserved. PMID: 31466119 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 29, 2019 Category: Dermatology Authors: Worm M, Bauer A, Elsner P, Mahler V, Molin S, Nielsen TSS Tags: Br J Dermatol Source Type: research

Toenail onychomycosis - it's no fungi to have around: treatment analysis to the rescue!
PMID: 31468505 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 29, 2019 Category: Dermatology Authors: Morris-Jones R Tags: Br J Dermatol Source Type: research

Classifying primary paediatric cutaneous mucinoses.
PMID: 31468512 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 29, 2019 Category: Dermatology Authors: Haber RM Tags: Br J Dermatol Source Type: research

Image gallery: Measles revival: Koplik's spots.
PMID: 31456220 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 27, 2019 Category: Dermatology Authors: Wang CH Tags: Br J Dermatol Source Type: research

Erdheim-Chester disease: how a dermatologist can help to diagnose an extremely rare serious disorder.
PMID: 31456240 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 27, 2019 Category: Dermatology Authors: Rose C Tags: Br J Dermatol Source Type: research

Utility of Repeat Latent Tuberculosis Testing with QuantiFERON-TB Gold test in Psoriasis Patients Treated with TNF- α inhibitors at a Single U.S. Institution.
This article is protected by copyright. All rights reserved. PMID: 31452192 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 27, 2019 Category: Dermatology Authors: Ya J, Khanna U, Havele S, Fernandez AP Tags: Br J Dermatol Source Type: research

AKT-dependent hyperproliferation of keratinocytes in familial hidradenitis suppurativa with NCSTN mutation: A potential role of defective miR-100-5p.
This article is protected by copyright. All rights reserved. PMID: 31448409 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 26, 2019 Category: Dermatology Authors: He Y, Li C, Xu H, Duan Z, Liu Y, Zeng R, Li M, Wang B Tags: Br J Dermatol Source Type: research

Dermatologist-level classification of malignant lip diseases using a deep convolutional neural network.
Abstract BACKGROUND: Deep convolutional neural networks (DCNNs) can classify skin diseases at a level equivalent to a dermatologist, but their performance on specific areas requires further research. OBJECTIVE: We aimed to evaluate the performance of a trained DCNN-based algorithm in classifying benign and malignant lip diseases. METHODS: A training set of 1629 images (743 malignant, 886 benign) was used with Inception-Resnet-V2. Performance was evaluated using another set of 344 images and 281 images from other hospitals. Classifications by 44 participants (6 board-certified dermatologists, 12 dermatolo...
Source: The British Journal of Dermatology - August 26, 2019 Category: Dermatology Authors: Cho SI, Sun S, Mun J, Kim C, Kim SY, Cho S, Youn SW, Kim HC, Chung JH Tags: Br J Dermatol Source Type: research

Topical zinc oxide: an effective treatment option for erosive pustular dermatosis of the leg.
This article is protected by copyright. All rights reserved. PMID: 31448408 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 25, 2019 Category: Dermatology Authors: Di Altobrando A, Patrizi A, Vara G, Merli Y, Bianchi T Tags: Br J Dermatol Source Type: research

Novel diagnostic method to differentiate antilaminin-332 pemphigoid from other forms of pemphigoid.
PMID: 31448410 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 25, 2019 Category: Dermatology Authors: Bilgic A, Murrell DF Tags: Br J Dermatol Source Type: research

TREatment of ATopic eczema (TREAT) Registry Taskforce: protocol for a European safety study of dupilumab and other systemic therapies in patients with atopic eczema.
CONCLUSIONS: This protocol delineates a safety study for dupilumab in adult and paediatric patients with atopic eczema, using a standardized methodological approach across several national registries. The protocol could also be used for other novel systemic immunomodulating therapies and could provide licensing and reimbursement authorities, pharmaceutical companies and clinicians with safety evidence from a routine clinical care setting. This article is protected by copyright. All rights reserved. PMID: 31444799 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 24, 2019 Category: Dermatology Authors: Bosma AL, Spuls PI, Garcia-Doval I, Naldi L, Prieto-Merino D, Tesch F, Apfelbacher CJ, Arents BWM, Barbarot S, Baselga E, Deleuran M, Eichenfield LF, Gerbens LAA, Irvine AD, Manca A, Mendes-Bastos P, Middelkamp-Hup MA, Roberts A, Seneschal J, Svensson Å, Tags: Br J Dermatol Source Type: research

Epidermolysis bullosa: diagnostic guidelines in the laboratory setting.
PMID: 31436321 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 22, 2019 Category: Dermatology Authors: Uitto J Tags: Br J Dermatol Source Type: research

Binimetinib in heavily pretreated NRAS-mutant Melanoma Patients with Brain Metastases.
Abstract Brain metastases are frequent in metastatic melanoma patients and indicate poor prognosis. Approximately 20% of all melanomas harbor an NRAS mutation (1). Although direct targeting RAS GTPase is difficult, preclinical in-vitro investigations suggest that melanomas harboring the NRAS mutation are sensitive to MEK inhibitors (2). Binimetinib, an orally bioavailable, selective and potent MEK1/2 inhibitor, has recently demonstrated improved progression-free survival (PFS) in patients with NRAS-mutant melanoma with no brain involvement compared to dacarbazine. PMID: 31436845 [PubMed - as supplied by publi...
Source: The British Journal of Dermatology - August 22, 2019 Category: Dermatology Authors: Goldinger SM, Valeska Matter A, Urner-Bloch U, Narainsing J, Micaletto S, Blume I, Mangana J, Dummer R Tags: Br J Dermatol Source Type: research

Higher self-reported severity of atopic dermatitis in adults is associated with poorer self-reported health-related quality of life in France, Germany, the UK and the US.
Abstract BACKGROUND: Better understanding of the relationship between atopic dermatitis (AD) severity and health-related quality of life (HRQoL) could help improve knowledge about the benefits of a more effective treatment of people with AD. OBJECTIVES: To assess the relationship between AD severity and HRQoL as well as with perception of AD symptoms, among adults with moderate-to-severe AD in Europe (France, Germany, and the UK) and the US. METHODS: The survey panel participants for this cross-sectional, internet-based survey in AD adults were recruited from the larger population-based National Health a...
Source: The British Journal of Dermatology - August 22, 2019 Category: Dermatology Authors: Andersen L, Nyeland ME, Nyberg F Tags: Br J Dermatol Source Type: research

Letter in Reply: Does IL-4 inhibition play a role in dupilumab-associated conjuncitivis?
Abstract In the article "Goblet cell scarcity and conjunctival inflammation during treatment with dupilumab in patients with atopic dermatitis," Bakker et al. suggest that dupilumab-associated conjunctivitis occurs because the "IL -13 blocking effect of dupilumab might lead to reduction of [conjunctival] G[oblet] C[ell]s and mucin production.1 " We suggest that concomitant IL-4 inhibition is important for conjunctivitis development as the lebrikizumab (IL-13 Inhibitor) phase 2 trial data showed a weaker conjunctivitis signal than has been observed with dupilumab. PMID: 31437304 [PubMed - a...
Source: The British Journal of Dermatology - August 22, 2019 Category: Dermatology Authors: Waldman R, Dewane ME, Sloan SB Tags: Br J Dermatol Source Type: research

The basket-weave pattern is present in the skin for a reason.
PMID: 31435930 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 21, 2019 Category: Dermatology Authors: Ishida-Yamamoto A Tags: Br J Dermatol Source Type: research

Image Gallery: Wandering Demodex mite in  vivo under ultraviolet dermoscopy of rosacea.
Image Gallery: Wandering Demodex mite in vivo under ultraviolet dermoscopy of rosacea. Br J Dermatol. 2019 Aug 20;: Authors: Singh N, Yang H, Pradhan S, Ran X, Ran Y PMID: 31432494 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 20, 2019 Category: Dermatology Authors: Singh N, Yang H, Pradhan S, Ran X, Ran Y Tags: Br J Dermatol Source Type: research

Image Gallery: Pellagra.
PMID: 31432495 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 20, 2019 Category: Dermatology Authors: Xu C, Zhang W, Chen H Tags: Br J Dermatol Source Type: research

Image Gallery: Mutilating diffuse cutaneous leishmaniasis in AIDS.
PMID: 31432498 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 20, 2019 Category: Dermatology Authors: Singh S, Rao M, Verma A Tags: Br J Dermatol Source Type: research

Diagnosis of Ehlers-Danlos syndrome: data deficiency still does not allow establishment of a complete history of the disease and its pathomechanisms.
PMID: 31432500 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 20, 2019 Category: Dermatology Authors: Hausser-Siller I Tags: Br J Dermatol Source Type: research

Apremilast does not appear to outlast methotrexate.
PMID: 31423571 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 19, 2019 Category: Dermatology Authors: Damiani G Tags: Br J Dermatol Source Type: research

Smartphones, artificial intelligence and digital histopathology take on basal cell carcinoma diagnosis.
PMID: 31429070 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 19, 2019 Category: Dermatology Authors: Lee KJ, Soyer HP Tags: Br J Dermatol Source Type: research

Appearance in acne: an often-overlooked concept.
PMID: 31423569 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 18, 2019 Category: Dermatology Authors: Gabes M Tags: Br J Dermatol Source Type: research

Secukinumab without the initial loading dose in the treatment of plaque-type psoriasis - a simplified dosing regimen at the expense of efficacy?
PMID: 31423570 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 18, 2019 Category: Dermatology Authors: Aichelburg MC, Tanew A Tags: Br J Dermatol Source Type: research

Severe childhood psoriasis: need for safety and efficacy data on long-term treatment with biologics.
PMID: 31423573 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 18, 2019 Category: Dermatology Authors: Belloni Fortina A, Caroppo F Tags: Br J Dermatol Source Type: research

The cost of childhood atopic dermatitis in a multi-ethnic Asian population: a cost-of-illness study.
CONCLUSIONS: Childhood atopic dermatitis imposes substantial costs with a large proportion arising from informal caregiving and out-of-pocket expenses. The cost for atopic dermatitis is also strongly related to disease severity. This information is important for policymakers and other health planners when considering how to better support affected families. This article is protected by copyright. All rights reserved. PMID: 31420964 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 17, 2019 Category: Dermatology Authors: Olsson M, Bajpai R, Wee LWY, Yew YW, Koh MJA, Thng S, Car J, Järbrink K Tags: Br J Dermatol Source Type: research

A novel NCSTN missense mutation in the signal peptide domain causes hidradenitis suppurativa, which has features characteristic of an autoinflammatory keratinization disease.
Abstract NCSTN encodes nicastrin, one of the three subunits of γ-secretase, a transmembrane endoprotease complex that catalyzes the cleavage of many transmembrane proteins including Notch receptors.1 In 2010, mutations in genes encoding γ-secretase subunits (NCSTN, PSENEN and PSEN1) were reported in cases of hidradenitis suppurativa (HS).2 It has been demonstrated that tumor necrosis factor-α and interleukin (IL) -10 levels are elevated in patients with HS with NCSTN mutations,1 although other reports found no elevation3 or found decreases. PMID: 31421058 [PubMed - as supplied by publisher] ...
Source: The British Journal of Dermatology - August 17, 2019 Category: Dermatology Authors: Takeichi T, Matsumoto T, Nomura T, Takeda M, Niwa H, Kono M, Shimizu H, Ogi T, Akiyama M Tags: Br J Dermatol Source Type: research

Developing an online patient education resource for topical therapy: a pilot study.
Abstract Topical therapies are first line treatments for the majority of skin conditions, yet many patients fail to use their treatments properly (1). Teaching patients how to use topical treatments is therefore an essential part of routine clinical care and improves treatment outcomes in atopic eczema and psoriasis. PMID: 31420862 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 16, 2019 Category: Dermatology Authors: Tull TJ, Jackson K, Smith CH, Pink AE Tags: Br J Dermatol Source Type: research

Effect of the lymphovascular plugging metastasis pattern in extramammary Paget disease on identifying metastatic lesions by imaging tests: An autopsy case series.
Abstract The prognosis of extramammary Paget disease (EMPD) is favourable if tumour cells are localised to the epidermis1 . However, patients with dermal and lymphatic invasion are at risk of metastasis, which is associated with poorer prognosis as no effective systemic therapy has been established2-4 . Patients with advanced EMPD present with characteristic metastatic patterns, such as underpants-distribution erythema and severe lymphoedema of the lower extremities resulting from lymphatic obstruction. PMID: 31420863 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 16, 2019 Category: Dermatology Authors: Maeda T, Yoshino K, Nagai K, Oaku S, Kato M, Hiura A, Uehara J, Fujisawa Y Tags: Br J Dermatol Source Type: research

DLQI-R scoring improves the discriminatory power of Dermatology Life Quality Index in psoriasis, pemphigus and morphea patients.
CONCLUSIONS: In morphea, pemphigus and psoriasis patients, the DLQI-R scoring improves the discriminatory power of the questionnaire by benefiting from the additional information in NRRs. The DLQI-R scoring may be useful both in clinical practice and research. A scoring chart has been developed to aid physicians with scoring. PMID: 31419310 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 16, 2019 Category: Dermatology Authors: Rencz F, Gulácsi L, Péntek M, Szegedi A, Remenyik É, Bata-Csörgő Z, Bali G, Hidvégi B, Tamási B, Poór AK, Hajdu K, Holló P, Kinyó Á, Sárdy M, Brodszky V Tags: Br J Dermatol Source Type: research

Laboratory safety of dupilumab in moderate-to-severe atopic dermatitis: results from three phase III trials (LIBERTY AD SOLO 1, LIBERTY AD SOLO 2, LIBERTY AD CHRONOS).
Abstract BACKGROUND: Dupilumab (monoclonal antibody blocking the shared receptor subunit for IL-4 and IL-13) is approved for patients aged ≥12 years with inadequately controlled, moderate-to-severe atopic dermatitis (AD). Dupilumab trials of up to 52 weeks demonstrated efficacy and a favourable safety profile in patients with moderate-to-severe AD inadequately controlled with topical medications. OBJECTIVE: To further characterise the safety of dupilumab by evaluating clinical laboratory findings from three randomised, double-blinded, placebo-controlled phase III trials (LIBERTY AD SOLO 1 & 2 and LIBER...
Source: The British Journal of Dermatology - August 13, 2019 Category: Dermatology Authors: Wollenberg A, Beck LA, Blauvelt A, Simpson EL, Chen Z, Chen Q, Shumel B, Khokhar FA, Hultsch T, Rizova E, Rossi AB, Graham NMH, Pirozzi G, Lu Y, Ardeleanu M Tags: Br J Dermatol Source Type: research

An Association between Hidradenitis Suppurativa and HIV.
This article is protected by copyright. All rights reserved. PMID: 31407315 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 13, 2019 Category: Dermatology Authors: Deng PH, Wang CJ, Armstrong AW Tags: Br J Dermatol Source Type: research

Image Gallery: A case of onychomatricoma with typical clinical, dermoscopic and histopathological findings.
PMID: 31407807 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 13, 2019 Category: Dermatology Authors: Zou XK, Yu J, Yang SX Tags: Br J Dermatol Source Type: research

Genetic Alterations in Primary Melanoma in Taiwan.
CONCLUSIONS: This study strengthens our understanding of the patterns and clinical associations of oncogenic mutations in AMs and NAMs in Asians. This article is protected by copyright. All rights reserved. PMID: 31408190 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 13, 2019 Category: Dermatology Authors: Sheen YS, Tan KT, Tse KP, Liao YH, Lin MH, Chen JS, Liau JY, Tseng YJ, Lee CH, Hong CH, Liao JB, Chang HT, Chu CY Tags: Br J Dermatol Source Type: research