Congenital bilateral scar-like lesions on the face.
PMID: 32696461 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 21, 2020 Category: Dermatology Authors: Durack A, Holden ST, Burrows NP Tags: Br J Dermatol Source Type: research

Ubiquitin, a novel therapeutic target in psoriasis?
PMID: 32696474 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 21, 2020 Category: Dermatology Authors: O'Shaughnessy RFL Tags: Br J Dermatol Source Type: research

A case of cowpox virus infection in the UK occurring in a domestic cat and transmitted to the adult male owner.
PMID: 32696487 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 21, 2020 Category: Dermatology Authors: Haddadeen C, Van Ouwerkerk M, Vicek T, Fityan A Tags: Br J Dermatol Source Type: research

Racial and Ethnic Differences in the Clinical Presentation and Outcomes of Acral Lentiginous Melanoma.
Abstract Acral lentiginous melanoma (ALM) is one of the four major subtypes of cutaneous melanoma (CM) and occurs on the palms, soles, and nail beds of the body. CM has often been associated with sun exposure1 , but ALM occurs in generally unexposed anatomic sites. While the aetiology remains largely unknown, melanocytic nevi, trauma, pressure, ultraviolet light, and gene mutations have been postulated in ALM development.2 ALM represents about 2-3% of all melanomas but represents a much higher proportion of CM in darker-skinned individuals.3 Racial and ethnic differences have been shown in CM.4 Due to its rarity, ...
Source: The British Journal of Dermatology - July 19, 2020 Category: Dermatology Authors: Behbahani S, Malerba S, Samie FH Tags: Br J Dermatol Source Type: research

Sustained improvement of surgical scar appearance one year after early intervention with nonablative fractional laser treatment: a randomized controlled split-wound trial.
Abstract Early laser treatment during wound healing has increasingly gained focus to improve scar formation1 . The majority of trials addressing early laser intervention for improving scar formation present short follow-up time of 1-3 months2 . Considering the pathophysiology of scar formation, a scar is not mature until a year post-injury. Thus, the effect of early laser treatment should be evaluated at least one year after scar intervention, and knowledge about long-term effect is lacking3-7 . PMID: 32668012 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 15, 2020 Category: Dermatology Authors: Grove GL, Banzhaf CA, Paasch U, Nast A, Haedersdal M, Karmisholt KE Tags: Br J Dermatol Source Type: research

Is baricitinib up next for atopic dermatitis?
PMID: 32657421 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 13, 2020 Category: Dermatology Authors: Drucker AM Tags: Br J Dermatol Source Type: research

Complete response of metastatic pleomorphic dermal sarcoma to anti-PD-1 therapy.
PMID: 32657425 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 13, 2020 Category: Dermatology Authors: Klein O, McTigue C, Wong ZW, Syme DB, Hunter-Smith DJ Tags: Br J Dermatol Source Type: research

Comparison of registered and published outcomes in randomised trials in dermatology journals: a cross-sectional analysis.
Abstract A potential source of bias in randomised controlled trial (RCTs) is selective outcome reporting bias, where outcomes for reporting are chosen based on the significance of their results.1 Significance can arise by chance when multiple tests are performed ("data dredging"). To avoid this problem, a main outcome (a "primary outcome") should be pre-specified prior to data collection in a time-stamped, publicly-available trial registry. Prospective registration has been a prerequisite for publication amongst International Committee of Medical Journal Editors (ICMJE) member journals since 20...
Source: The British Journal of Dermatology - July 11, 2020 Category: Dermatology Authors: Steele L, Livesey A, Hong A, Thomson J, Flohr C Tags: Br J Dermatol Source Type: research

Secukinumab two weekly versus four weekly dosing in patients with plaque-type psoriasis: results from the randomized GAIN study.
huber T Abstract BACKGROUND: Secukinumab is a fully human monoclonal antibody that selectively neutralizes IL-17A and shows long lasting efficacy and safety in plaque psoriasis. More evidence is required to optimize secukinumab dosing according to clinical response. OBJECTIVES: GAIN compared the efficacy and safety of secukinumab 300 mg every two weeks (q2w) with 300mg every 4 weeks (q4w) in patients achieving PASI75 but not PASI90 after 16 weeks. PATIENTS AND METHODS: 772 patients with moderate to severe plaque psoriasis received secukinumab 300mg s.c. at baseline, Weeks 1, 2, 3 and 4, then q4w until We...
Source: The British Journal of Dermatology - July 11, 2020 Category: Dermatology Authors: Reich K, Körber A, Mrowietz U, Sticherling M, Sieder C, Früh J, Bachhuber T Tags: Br J Dermatol Source Type: research

Epidermal growth factor receptor inhibitor therapy-associated erythema dyschromicum perstans-like eruption: a case series.
Abstract Epidermal growth factor receptor inhibitors (EGFRi) are used for a variety of solid malignancies. Cutaneous adverse events are common, and include papulopustular eruptions (PPEs) in up to 90% of patients, xerosis, mucositis, paronychia, hypertrichosis, and enhanced radiation dermatitis.1-3 Here, we present a novel case series of eight patients who developed erythema dyschromicum perstans (EDP)-like eruptions while receiving EGFRis. PMID: 32652530 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 11, 2020 Category: Dermatology Authors: Ransohoff KJ, Pugliese SB, Zaba LC, Rieger KE, Kwong BY Tags: Br J Dermatol Source Type: research

Long-Term Efficacy of Certolizumab Pegol for the Treatment of Plaque Psoriasis: Three-Year Results from Two Randomised Phase 3 Trials (CIMPASI-1 and CIMPASI-2).
CONCLUSIONS: Both CZP 200 mg and 400 mg Q2W demonstrated sustained, durable efficacy, with numerically higher responses for some outcomes with 400 mg Q2W. PMID: 32652544 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 11, 2020 Category: Dermatology Authors: Gordon KB, Warren RB, Gottlieb AB, Blauvelt A, Thaçi D, Leonardi C, Poulin Y, Boehnlein M, Brock F, Ecoffet C, Reich K Tags: Br J Dermatol Source Type: research

Reliable assessment of atopic dermatitis severity: do we need more tools?
Abstract Facing the need to obtain more robust and reliable results from studies on various therapeutic modalities and the growing costs of clinical trials, a valid assessment of disease severities has now become particularly relevant. Regarding atopic dermatitis (AD), many available measures exist for its assessment; however, none is currently considered as a gold standard. The major difficulty in assessing AD severity relies on the need to evaluate both objective clinical severity as well as the subjective symptoms reported by patients. PMID: 32652550 [PubMed - as supplied by publisher] (Source: The British...
Source: The British Journal of Dermatology - July 11, 2020 Category: Dermatology Authors: Reich A Tags: Br J Dermatol Source Type: research

Targeted and immunotherapies in BRAF mutant melanoma - where we are standing and what to expect.
Abstract The therapeutic landscape for melanoma evolved drastically in the past decade. Currently, immune checkpoint inhibitors and small molecule inhibitors targeting the MAPK pathway are the two mainstay therapies for BRAF V600 mutant advanced melanoma. Although MAPK dependence has been variably demonstrated in melanomas lacking BRAF V600 mutations, definitive evidence of benefit with MAPK inhibitors has not been demonstrated. Thus, in the BRAF V600 "wild-type" setting, immune checkpoint inhibitors are the standalone option(s). In the BRAF V600 mutant setting, there is no definitive evidence prioritizi...
Source: The British Journal of Dermatology - July 11, 2020 Category: Dermatology Authors: Bai X, Flaherty KT Tags: Br J Dermatol Source Type: research

Active versus standard sun protection in patients with melanoma stage I or II: A randomised controlled feasibility trial assessing compliance with sun protection and quality of life.
Abstract The incidence of melanoma is steadily increasing in the Western hemisphere, and one key factor is UV exposure. Sun protection is essential, particularly in patients with diagnosed melanoma. However, data on the psychological implications of sunscreen protection in melanoma patients are lacking. This project was designed as a randomised controlled feasibility trial to explore the feasibility of the diary method and tube count to assess patient compliance in the setting of a monocentric trial, furthermore to observe any recognisable trends regarding anxiety and QoL between the intervention and control group...
Source: The British Journal of Dermatology - July 11, 2020 Category: Dermatology Authors: Goeth H, Koller M, Hegemann MV, Drexler K, Zeman F, Huppertz G, Berneburg M, Maisch T Tags: Br J Dermatol Source Type: research

Frontal fibrosing alopecia: a descriptive cross-sectional study of 711 female cases from the U.K.
pagne C, Cooper HL, Patel GK, Macbeth A, Page M, Bryden A, Mowbray M, Wahie S, Armstrong K, Cooke N, Goodfield M, Man I, de Berker D, Dunnil G, Takwale A, Rao A, Siah TW, Sinclair R, Wade MS, Bhargava K, Fenton DA, McGrath JA, Tziotzios C Abstract Frontal fibrosing alopecia (FFA) is an inflammatory primary scarring alopecia of uncertain aetiology that represents a variant of lichen planopilaris.1 It predominantly, although not exclusively, affects post-menopausal women.2 Its pathogenesis is characterised by immune-mediated follicular destruction at the level of the hair bulge, which leads to a clinical phenotype o...
Source: The British Journal of Dermatology - July 11, 2020 Category: Dermatology Authors: McSweeney SM, Christou EAA, Dand N, Boalch A, Holmes S, Harries M, Palamaras I, Cunningham F, Parkins G, Kaur M, Farrant P, McDonagh A, Messenger A, Jones J, Jolliffe V, Ali I, Ardern-Jones M, Mitchell C, Burrows N, Atkar R, Banfield C, Alexandroff A, Cha Tags: Br J Dermatol Source Type: research

New oral antifungals for onychomycosis: interesting potential and the need for comparative effectiveness trials.
PMID: 32643171 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 9, 2020 Category: Dermatology Authors: Barbieri JS Tags: Br J Dermatol Source Type: research

Most chilblains observed during the COVID-19 outbreak occur in patients who are negative for COVID-19 on PCR and serology testing.
CONCLUSION: The results of this survey do not rule out that SARS-CoV-2 could be directly responsible for some cases of chilblains but found no evidence of SARS-CoV-2 infection in large majority of patients with acral lesions during the COVID-19 lockdown period in France. PMID: 32628270 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 6, 2020 Category: Dermatology Authors: Le Cleach L, Dousset L, Assier H, Fourati S, Barbarot S, Boulard C, Bourseau Quetier C, Cambon L, Cazanave C, Colin A, Kostrzewa E, Lesort C, Levy Roy A, Lombart F, Marco-Bonnet J, Monfort JB, Samimi M, Tardieu M, Wolkenstein P, Sbidian E, Beylot-Barry M, Tags: Br J Dermatol Source Type: research

A decade of next-generation sequencing in genodermatoses: the impact on gene discovery and clinical diagnostics.
CONCLUSIONS: NGS technologies have accelerated disease-gene discoveries in dermatology over the last decade. Moreover, the era of NGS has enabled clinicians to split complex Mendelian phenotypes into separate diseases. These genetic data improve diagnostic precision and make feasible accurate prenatal testing and better-targeted translational research. PMID: 32628274 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 6, 2020 Category: Dermatology Authors: Chiu FP, Doolan BJ, McGrath JA, Onoufriadis A Tags: Br J Dermatol Source Type: research

Incidence and outcome of Spitzoid Tumour of Unknown Malignant Potential (STUMP). An analysis of cases in the Netherlands from 1999 till 2014.
Abstract Spitz naevi are spindle and epithelioid cell melanocytic proliferations that Sophie Spitz first described in 1948 as "juvenile melanomas" [1]. The broader group of Spitzoid proliferations is thought to comprise a biological spectrum with benign Spitz naevi, intermediate lesions and malignant Spitzoid melanomas. Intermediate lesions are known by various synonyms such as atypical Spitz tumours (AST) and Spitzoid tumours of unknown malignant potential (STUMP). These intermediate lesions share features of both Spitz naevi and Spitzoid melanomas. Subsequently they represent a diagnostic grey zone and...
Source: The British Journal of Dermatology - July 6, 2020 Category: Dermatology Authors: Ruijter CGH, Ouwerkerk W, Jaspars EH, van Doorn R, Luiten RM, Bekkenk MW, Tio DCKS Tags: Br J Dermatol Source Type: research

Indoor salt water baths followed by artificial ultraviolet B-light for chronic plaque psoriasis: abridged Cochrane review.
Abstract It has been suggested that indoor salt water baths with exposure to artificial UVB, may benefit patients with psoriasis.1 Artificial exposure to ultraviolet B-light (UVB) while soaking in an indoor salt bath, also called balneophototherapy, could simulate the natural exposure to the sun while bathing in the Dead Sea.2 However, the evidence underlying clinical efficacy, such as longer remission from disease and higher dermatology-related quality of life, has not yet been clearly evaluated. In a Cochrane review,3 we evaluated whether the combined application of indoor salt bath and ultraviolet B-light (UVB)...
Source: The British Journal of Dermatology - July 6, 2020 Category: Dermatology Authors: Peinemann F, Harari M, Peternel S, Chan T, Chan D, Labeit AM, Gambichler T Tags: Br J Dermatol Source Type: research

Notice of Withdrawal.
Authors: PMID: 32628770 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 6, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

Biopsy Outperforms Reflectance Confocal Microscopy in Diagnosing and Subtyping Basal Cell Carcinoma: Results and Experiences from a Randomized Controlled Multicentre Trial.
Abstract BACKGROUND: Reflectance confocal microscopy (RCM) is a non-invasive method for skin assessment, allowing entire lesion evaluation up to the papillary dermis. Therefore, RCM is a potentially attractive alternative to punch biopsy in basal cell carcinoma (BCC). OBJECTIVES AND DESIGN: This randomized controlled trial aimed to investigate RCM as alternative to punch biopsy in a real-world clinical setting. Primary objective was to determine the diagnostic accuracy of RCM compared to punch biopsy in diagnosing and subtyping BCC. Secondary objectives were to study related patient satisfaction and preferenc...
Source: The British Journal of Dermatology - July 6, 2020 Category: Dermatology Authors: Woliner-van der Weg W, Peppelman M, Elshot YS, Visch MB, Crijns MB, Alkemade HAC, Bronkhorst EM, Adang E, Amir A, Gerritsen MJP, van Erp PEJ, Lubeek SFK Tags: Br J Dermatol Source Type: research

Role of regulatory T  cells in psoriasis pathogenesis and treatment.
Role of regulatory T cells in psoriasis pathogenesis and treatment. Br J Dermatol. 2020 Jul 06;: Authors: Nussbaum L, Chen YL, Ogg GS Abstract Psoriasis is a chronic inflammatory disease with a strong genetic component that can be triggered by environmental factors. Disease pathogenesis is mainly driven by type 1 and type 17 cytokine-producing cells which, in healthy individuals, are modulated by regulatory T cells (Tregs). Tregs play a fundamental role in immune homeostasis and contribute to the prevention of autoimmune disease by suppressing immune responses. In psoriasis, Tregs ...
Source: The British Journal of Dermatology - July 6, 2020 Category: Dermatology Authors: Nussbaum L, Chen YL, Ogg GS Tags: Br J Dermatol Source Type: research

Assessing the Quality of Intervention Reporting in Dermatology Randomised Controlled Trials Using the TIDieR Checklist.
Abstract Randomised controlled trials (RCTs) are central to evidence-based medicine because they support making causal inferences about treatments and mitigate bias through randomisation and blinding.1 However, RCTs have exhibited low-quality methodology2 and reporting,3 which may compromise the trustworthiness and validity of their results. Critics have called for more accurate and detailed reporting of RCT interventions4 ,5 to enable reproduction of the original trial. Interventions that are poorly reported may be unusable by dermatologists who seek to translate the evidence-based research findings to daily prac...
Source: The British Journal of Dermatology - July 6, 2020 Category: Dermatology Authors: Bindernagel R, Cook C, Wayant C, Jellison S, Vassar M Tags: Br J Dermatol Source Type: research

Effectiveness of a stop smoking service in reducing cigarette smoking in patients referred from an NHS dermatology centre.
Abstract Cigarette smoking is the leading avoidable cause of mortality in the UK. Individuals who start smoking in early adult life lose 10 years of life expectancy.1 Smoking is a risk factor for psoriasis [odds ratio (OR) of 1.94, 95% confidence interval (CI) 1.64-2.28], hidradenitis suppurativa (HS, OR 1.90, 95% CI 1.84-1.96), healing delay (OR 2.07, 95% CI 1.53-2.81), surgical site infection (OR 1.79, 95% CI 1.57-2.04), wound complications (OR 2.27, 95% CI 1.82-2.84), and melanoma (relative risk 1.7, 95% CI 1.2-2.6).2-5 UK NHS stop-smoking services (SSS) provide behavioural support delivered by trained practiti...
Source: The British Journal of Dermatology - July 4, 2020 Category: Dermatology Authors: Soriano LF, Poole H, Ingram JR, Abbott RA Tags: Br J Dermatol Source Type: research

Response to: "Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases": Vesicular eruption in COVID-19 - to exclude varicella.
Response to: "Classification of the cutaneous manifestations of COVID-19: a rapid prospective nationwide consensus study in Spain with 375 cases": Vesicular eruption in COVID-19 - to exclude varicella. Br J Dermatol. 2020 Jul 01;: Authors: Lim SYD, Tey HL Abstract We read with interest the classification of cutaneous manifestations in Coronavirus disease 19 (COVID-19) by C. Galván Casas et al.1 In particular, vesicular eruptions are characterized as monomorphic vesicles, involving the trunk, happening early in the course of the disease, and occasionally preceding other symptoms1-3 . H...
Source: The British Journal of Dermatology - July 1, 2020 Category: Dermatology Authors: Lim SYD, Tey HL Tags: Br J Dermatol Source Type: research

Chilblain-like lesions during COVID-19 pandemic: a serological study on a case series.
Abstract The outbreak of chilblain-like lesions (CLL) coincidentally to the COVID-19 pandemic is a topic of great concern. SARS-CoV-2 has been hypothesized as the etiologic agent of CLL, on the basis of the temporal correlation between the "burst" of skin manifestations and the viral pandemic. However, the relationship between CLL and COVID-19 remains unclear, since authors failed to confirm the SARS-CoV-2 infection in these patients using a real-time reverse transcription polymerase chain reaction (rt-PCR) test from nasopharyngeal swabs, which seldom resulted positive. Indeed, the most recent articles o...
Source: The British Journal of Dermatology - July 1, 2020 Category: Dermatology Authors: Rizzoli L, Collini L, Magnano M, Termine S, Barcelli R, Infusino SD, Bauer P, Rech G, Girardelli CR, Balestri R Tags: Br J Dermatol Source Type: research

"Vesicular eruption in COVID-19 - to exclude varicella": reply from the authors.
"Vesicular eruption in COVID-19 - to exclude varicella": reply from the authors. Br J Dermatol. 2020 Jul 01;: Authors: Català A, Galván Casas C, Carretero Hernández G, García-Doval I Abstract We and agree with Drs Lim and Tey on the need to exclude varicella in vesicular eruptions in patients with COVID-19, as this diagnosis has important implications. Once that it is established that some patients with COVID-19 can have a vesicular eruption, there is a need to further characterize this group of patients. The link of some of these lesions with herpesvirus infectio...
Source: The British Journal of Dermatology - July 1, 2020 Category: Dermatology Authors: Català A, Galván Casas C, Carretero Hernández G, García-Doval I Tags: Br J Dermatol Source Type: research

No evidence of SARS-Cov-2 infection by PCR or serology in children with pseudochilblain.
ve; M Abstract Despite its aggressive clinical course, leading to 6.4% fatality rate as of May 25, 2020 (https://qap.ecdc.europa.eu/public/extensions/COVID-19/COVID-19.html), COVID-19 turned out to be only marginally aggressive in children. In a report from Lombardy, 18/88 COVID-19 hospitalized adults (20%) had developed cutaneous manifestations: erythematous rash, widespread urticarial, and chickenpox-like vesicles. Trunk was the main involved region. Itching was low or absent and usually lesions healed in few days. An unexpected outbreak of acute pseudochilblain skin lesions is being reported from different coun...
Source: The British Journal of Dermatology - July 1, 2020 Category: Dermatology Authors: Caselli D, Chironna M, Loconsole D, Nigri L, Mazzotta F, Bonamonte D, Aricò M Tags: Br J Dermatol Source Type: research

A study into the drug dupilumab in Japanese adults with moderate-to-severe atopic dermatitis.
Authors: Abstract Atopic dermatitis (AD), a long-lasting skin disease characterized by intense itching and dry, red, swollen and cracked skin, affects between 2% and 10% of Japanese adults. In Japan, patients with moderate-to-severe or very severe AD have limited treatment options, most with unwanted side effects. There is a need for therapies that provide safe and effective long-term control. The underlying mechanism of AD may differ between Asian and Western patients, and this study aimed to evaluate dupilumab, a drug that blocks key molecules that cause AD, in Japanese patients with moderate-to-severe AD. The ...
Source: The British Journal of Dermatology - July 1, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

All aboard the BJD for global dissemination of high-quality dermatology clinical practice guidelines.
PMID: 32613650 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 1, 2020 Category: Dermatology Authors: Yiu ZZN, Chi CC, Flohr C Tags: Br J Dermatol Source Type: research

A viral rash: the impact of COVID-19 infection on the skin.
PMID: 32613651 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 1, 2020 Category: Dermatology Authors: Hay RJ Tags: Br J Dermatol Source Type: research

Gingival telangiectasia of dermatomyositis.
PMID: 32608029 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 30, 2020 Category: Dermatology Authors: Milani-Nejad N, Kaffenberger J Tags: Br J Dermatol Source Type: research

Global Hidradenitis Suppurativa COVID-19 Registry: A Registry to Inform Data-Driven Management Practices.
Abstract The management of hidradenitis suppurativa (HS), a chronic inflammatory skin disease, deserves special consideration in the context of the Coronavirus 2019 (COVID-19) pandemic. A new Global Hidradenitis Suppurativa COVID-19 Registry has been developed to capture data on risks, clinical course, and outcomes of COVID-19 in HS patients. Caused by the virus SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2), COVID-19 is an easily transmissible disease which, in its most severe form, is characterized by respiratory failure and multiple organ dysfunction triggered by a cytokine storm response that pre...
Source: The British Journal of Dermatology - June 29, 2020 Category: Dermatology Authors: Naik HB, Alhusayen R, Frew J, Guilbault S, Ingram JR, Lowes MA, Marzano AV, Paul M, Villumsen B, Yannuzzi CA Tags: Br J Dermatol Source Type: research

A 10-year Review of Surgical Management of Dermatofibrosarcoma Protuberans.
CONCLUSIONS: WLE was the commonest surgical modality used to treat DFSP across the UK. The local recurrence rate was very low, occurring only after WLE. Although a prospective RCT may provide more definitive outcomes, in the absence of a clearly superior surgical modality, treatment decisions should be based on patient preference, clinical expertise and cost. PMID: 32599647 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 29, 2020 Category: Dermatology Authors: Durack A, Gran S, Gardiner MD, Jain A, Craythorne E, Proby CM, Marsden J, Harwood CA, Matin RN, DFSP Collaborators Tags: Br J Dermatol Source Type: research

Validation of Patient Global Item for Quality of Life Impact on Hidradenitis Suppurativa.
Abstract BACKGROUND: Hidradenitis suppurativa (HS) is a chronic inflammatory disease that is not well understood. The HS core outcome set calls for a patient global assessment (PtGA), for which measures are limited. OBJECTIVES: Our aim is to assess the validity, reliability, and responsiveness of a candidate single-item PtGA for HS-specific health-related quality of life (HRQOL). METHODS: Cognitive debriefing interviews were conducted with HS patients in Denmark (DK) and the United States (US). Field testing was conducted via a cross-sectional observational study with adults with HS in the US and DK. The...
Source: The British Journal of Dermatology - June 29, 2020 Category: Dermatology Authors: Kirby JS, Hereford B, Thorlacius L, Villumsen B, Ingram JR, Garg A, Butt M, Esmann S, King T, Tan J, Jemec GBE Tags: Br J Dermatol Source Type: research

Doppler Ultrasound-Based Non-Invasive Biomarkers in Hidradenitis Suppurativa: Evaluation of Analytical and Clinical Validity.
CONCLUSIONS: Sonographic epidermal thickness and dermal tunnel diameter have acceptable levels of analytical validity in the assessment of HS lesions. Power Doppler intensity demonstrates acceptable clinical and analytical validity suggesting it is a valid imaging-based biomarker in HS. PMID: 32602132 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 29, 2020 Category: Dermatology Authors: Grand D, Frew JW, Navrazhina K, Krueger JG Tags: Br J Dermatol Source Type: research

Development and efficacy of a nested real-time quantitative polymerase chain reaction to identify the cytochrome c oxidase subunit 1 gene of Sarcoptes scabiei var. hominis for diagnosis and monitoring of ordinary scabies.
Abstract Dear Editor, Scabies infestation is increasingly a public health concern, even in high-income countries. The disability-adjusted life-years (DALYs) globally was estimated to be 71·11 (95% CI 39·77-116·03) per 100,000 people based on the results of a cross-sectional analysis from the Global Burden of Disease Study 20158 . The gold standard for scabies diagnosis is microscopic examination of skin scrapings in mineral oil, but the sensitivity of this technique is low3 ; as a result, scabies infestation cannot be ruled out even when this test is negative. PMID: 32594512 [PubMed - as ...
Source: The British Journal of Dermatology - June 28, 2020 Category: Dermatology Authors: Kim JK, Chun EJ, Yang SY, Kim KS, Kim SS, Kim CW Tags: Br J Dermatol Source Type: research

Efficacy and safety of risankizumab vs. secukinumab in patients with moderate-to-severe plaque psoriasis (IMMerge): Results from a phase 3, randomised, open-label, efficacy assessor-blinded clinical trial.
Abstract BACKGROUND: Patients with plaque psoriasis treated with biologic therapies need more efficacious, safe, and convenient treatments to improve quality of life. Risankizumab and secukinumab inhibit interleukin (IL)-23 and IL-17A, respectively, and are effective in adult patients with moderate-to-severe plaque psoriasis but have different dosing regimens. OBJECTIVES: Directly compare efficacy and safety of risankizumab vs. secukinumab over 52 weeks. METHODS: IMMerge was an international, phase 3, multicentre, open-label, efficacy assessor-blinded, active-comparator study, in which adult patients wit...
Source: The British Journal of Dermatology - June 28, 2020 Category: Dermatology Authors: Warren RB, Blauvelt A, Poulin Y, Beeck S, Kelly M, Wu T, Geng Z, Paul C Tags: Br J Dermatol Source Type: research

Mutations in genes encoding desmosomal proteins: spectrum of cutaneous and extracutaneous abnormalities.
Abstract The desmosome is a type of intercellular junction found in epithelial cells, cardiomyocytes and other specialised cell types. Composed of a network of transmembranous cadherins and intracellular armadillo, plakin and other proteins, desmosomes contribute to cell-cell adhesion, signalling, development and differentiation. Mutations in genes encoding desmosomal proteins result in a spectrum of erosive skin and mucosal phenotypes that also may affect hair or heart. This review summarises the molecular pathology and phenotypes associated with desmosomal dysfunction with a focus on inherited disorders that inv...
Source: The British Journal of Dermatology - June 27, 2020 Category: Dermatology Authors: Lee JYW, McGrath JA Tags: Br J Dermatol Source Type: research

Dermatological signs lead to discovery of mosaic ACTB variants in segmental odonto-maxillary dysplasia.
Abstract Segmental odontomaxillary dysplasia (SOD) is a rare condition of unknown incidence, with approximately 60 cases reported (as reviewed in 2018)1 . It presents at birth or during childhood with a constellation of ipsilateral facial signs: non-progressive/slowly-progressive overgrowth or undergrowth of soft tissues and/or bones (typically centred on the posterior maxilla, and leading to facial asymmetry), dental anomalies (missing teeth or abnormal dentition), gingival hyperplasia or abnormal gingivae, commissural lip fissures, hypertrichosis, cutaneous hyperpigmentation and/or erythema, cutaneous depression...
Source: The British Journal of Dermatology - June 25, 2020 Category: Dermatology Authors: Polubothu S, Abdin D, Barysch M, Thomas A, Bulstrode N, Evans R, Solman L, Obwegeser J, Hennekam RC, Weibel L, Calder A, Di Donato N, Kinsler VA Tags: Br J Dermatol Source Type: research

COVID-19 chilblain-like lesion: immunohistochemical demonstration of SARS-CoV-2 spike protein in blood vessel endothelium and sweat gland epithelium in a PCR-negative patient.
, Requena L Abstract A 35-year-old woman with no significant previous medical history presented at the Emergency Department of Fundación Jiménez Díaz Hospital (Madrid, Spain) on April 14th with acral purpuric lesions of three weeks duration. These had started as oedematous, erythematous areas and had appeared coincidentally with fever and coughing, which lasted only two days. There was no history of diarrhoea, ageusia, hyposmia or dyspnea. The patient stated that the skin of her feet acquired a bluish discoloration after standing for some time. PMID: 32585767 [PubMed - as supplied by publ...
Source: The British Journal of Dermatology - June 25, 2020 Category: Dermatology Authors: Santonja C, Heras F, Núñez L, Requena L Tags: Br J Dermatol Source Type: research

Epigastric cutaneous discharge: think amoebiasis.
lot M PMID: 32588425 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 25, 2020 Category: Dermatology Authors: Merad Y, Behague L, Valot S, Basmaciyan L, Dalle F, Estève C, Catherine FX, Blot M Tags: Br J Dermatol Source Type: research

Basaloid follicular proliferations, brain tumours and SUFU.
PMID: 32588433 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 25, 2020 Category: Dermatology Authors: Manam S, Oliphant T, Husain A, Rajan N Tags: Br J Dermatol Source Type: research

Suspension of marketing authorisation for ingenol mebutate.
Abstract The authors of the British Association of Dermatologists' (BAD) clinical guidelines for managing actinic keratosis and the BAD's Therapy & Guidelines sub-committee wish to notify readers of the 2017 guideline publication that the marketing authorisation for ingenol mebutate has been suspended by the United Kingdom's Medicines and Healthcare products Regulatory Agency (MHRA) on 27th January 2020. This is due to emerging evidence suggesting possible links between use of the product with an increased risk of developing skin cancers. The manufacturers are recalling all stocks of this medication. Further a...
Source: The British Journal of Dermatology - June 24, 2020 Category: Dermatology Authors: Mohd Mustapa MF, de Berker D, McGregor JM, Exton LS, Hughes BR, Levell NJ Tags: Br J Dermatol Source Type: research

Efficacy and safety of topical resorcinol 15% as long-term treatment of mild-moderate hidradenitis suppurativa: a valid alternative to clindamycin in the panorama of antibiotic resistance.
Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory disease that affects the hair follicle in the apocrine gland-bearing regions. Although HS is not primarily caused by bacterial infection, antibiotics represent the first line treatment in the management of HS primarily for their anti-inflammatory properties, with additional contributions via antimicrobial and immunomodulatory effects. PMID: 32579711 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 24, 2020 Category: Dermatology Authors: Molinelli E, Brisigotti V, Simonetti O, Campanati A, Sapigni C, D'Agostino GM, Giacchetti A, Cota C, Offidani A Tags: Br J Dermatol Source Type: research

Should we be imaging lymph nodes at initial diagnosis of early-stage mycosis fungoides? Results from the PROCLIPI international Study.
CONCLUSION: Physical examination was a poor determinant of LN enlargement/involvement. Presence of plaques was associated with significant increase in identification of enlarged/involved LN in patients with early-stage presentation of MF, which may be important when deciding who to image. Imaging increases detection rate of stage-IIA, and identifies rare cases of extensive lymphomatous nodes, upstaging them to advanced-stage IVA2. PMID: 32574377 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 23, 2020 Category: Dermatology Authors: Hodak E, Sherman S, Papadavid E, Bagot M, Querfeld C, Quaglino P, Prince HM, Ortiz-Romero PL, Stadler R, Knobler R, Guenova E, Estrach T, Patsatsi A, Leshem YA, Prague-Naveh H, Berti E, Alberti-Violetti S, Cowan R, Jonak C, Nikolaou V, Mitteldorf C, Akilo Tags: Br J Dermatol Source Type: research

QuantiFERON TB-gold  conversion is not uncommon in psoriasis patients under anti-TNF-α: reply from author.
QuantiFERON TB-gold conversion is not uncommon in psoriasis patients under anti-TNF-α: reply from author. Br J Dermatol. 2020 Jun 22;: Authors: Fernandez AP Abstract We thank Megna et al. for their interest in our article. However, we respectfully disagree that annual QFT testing should be adopted for every psoriasis patient treated with TNF-α inhibitors (TNFIs). To optimize the risk:benefit ratio of any screening test, it is important to define a high-risk subgroup1 . For example, annual lung cancer screening is not recommended in all smokers, but specifically older smokers who have ...
Source: The British Journal of Dermatology - June 22, 2020 Category: Dermatology Authors: Fernandez AP Tags: Br J Dermatol Source Type: research

Sars-CoV-2 infection: the same virus can cause different cutaneous manifestations: reply from authors.
G, Garcia-Doval I Abstract Dr Drago et al. are right to point out that our paper did not provide data on enanthems1,2 . As the data collection form did not include the description of mucous membranes, they might have not been explored in many patients. We have reported and included in the supplementary material a few cases that were noticed by their doctors and were the first descriptions of enanthem in COVID-19. Given the low number of cases and their non-systematic acquisition, we avoided any analysis of these data. PMID: 32569387 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 22, 2020 Category: Dermatology Authors: Galván-Casas C, Catalá A, Carretero Hernández G, Garcia-Doval I Tags: Br J Dermatol Source Type: research

Systemic treatment in atopic dermatitis after 2018: from experienced-based treatment to evidence-based treatment?
PMID: 32567048 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - June 21, 2020 Category: Dermatology Authors: de Bruin-Weller M Tags: Br J Dermatol Source Type: research