The value of case reports and spontaneous reporting systems for pharmacovigilance and clinical practice.
Abstract We greatly appreciate a recent Editorial remarking the value of published case reports in drug safety and underlines the too often overlooked importance of reporting adverse drug reactions (i.e., adverse events suspectedly attributed to drug exposure) to a pharmacovigilance system. 1 Dermatologists are facing new challenges in real-world pharmacovigilance. On one hand, skin manifestations are increasingly documented with anticancer drugs and require multidisciplinary management since cutaneous adverse events have been proposed as potential biomarkers of drug efficacy, implying a delicate balance between t...
Source: The British Journal of Dermatology - November 13, 2020 Category: Dermatology Authors: Raschi E, La Placa M, Poluzzi E, De Ponti F Tags: Br J Dermatol Source Type: research

Linked in: the extracellular matrix network in tumour dissemination.
uer J PMID: 33179769 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 12, 2020 Category: Dermatology Authors: Leb-Reichl V, Guttmann-Gruber C, Piñon Hofbauer J Tags: Br J Dermatol Source Type: research

A different finding on whether naevus numbers change during adulthood.
PMID: 33179777 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 12, 2020 Category: Dermatology Authors: Cust AE Tags: Br J Dermatol Source Type: research

Skin cancer awareness and prevention behaviour in Wales.
Abstract Skin cancer incidence is increasing worldwide with higher incidence rates in Wales compared to other UK countries.1,2 The majority of skin cancers are caused by over exposure to ultraviolet radiation and prevention measures are recommended at government level and by individuals.3,4 In Wales, the Sunbeds Act was passed in 2010 prohibiting under 18s from using sunbeds. PMID: 33179262 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 11, 2020 Category: Dermatology Authors: Ziaj S, Tseliou F, Datta D, Abbott RA Tags: Br J Dermatol Source Type: research

Recommended core outcome instruments for health-related quality of life, long-term control and itch intensity in atopic eczema trials: results of the HOME VII consensus meeting.
CONCLUSIONS: For now, the core outcome set for clinical trials in atopic eczema is complete. The specified domains and instruments should be used in all new clinical trials and systematic reviews of eczema treatments. PMID: 33179283 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 11, 2020 Category: Dermatology Authors: Thomas KS, Apfelbacher CA, Chalmers JR, Simpson E, Spuls PI, Gerbens LAA, Williams HC, Schmitt J, Gabes M, Howells L, Stuart BL, Grinich E, Pawlitschek T, Burton T, Howie L, Gadkari A, Eckert L, Ebata T, Boers M, Saeki H, Nakahara T, Katoh N Tags: Br J Dermatol Source Type: research

Ruxolitinib cream for treatment of vitiligo: a randomised, controlled, phase 2 trial: a critical appraisal.
Abstract Vitiligo is an acquired condition which presents as cutaneous depigmentation. There is no licensed treatment for the re-pigmentation of vitiligo lesions, however, several therapies are used routinely and have been studied in clinical trials. These include: topical corticosteroids, calcineurin inhibitors and phototherapy. PMID: 33179290 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 11, 2020 Category: Dermatology Authors: Cotter C, Ferguson J Tags: Br J Dermatol Source Type: research

Systematic review to identify and appraise patient-reported outcome measures on treatment satisfaction in acne.
CONCLUSIONS: We could not find a PROM on treatment satisfaction to recommend for a core outcome set in acne. There is an unmet need for a PROM measuring treatment satisfaction in acne that is robustly developed, designed and validated. PMID: 33176002 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 11, 2020 Category: Dermatology Authors: van Zuuren EJ, Arents BWM, Miklas M, Schoones JW, Tan J Tags: Br J Dermatol Source Type: research

Presence of streptococci and frequent tonsillitis among adolescents with psoriasis.
kov L Abstract Many dermatologists may appreciate the role that tonsillar infections with Streptococcus pyogenes play in exacerbating or triggering their patients' psoriasis. Especially relevant is the role of tonsillar streptococcal colonization in guttate psoriasis and in some cases in plaque psoriasis.1, 2 Perianal streptococcal infection has been observed in guttate psoriasis. PMID: 33174209 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 10, 2020 Category: Dermatology Authors: Groot J, Blegvad C, Nybo Andersen AM, Zachariae C, Jarløv JO, Skov L Tags: Br J Dermatol Source Type: research

Caf é au lait macules overlying segmental macular hyperpigmentation in a paediatric patient: an early sign for mosaic neurofibromatosis type 1.
Café au lait macules overlying segmental macular hyperpigmentation in a paediatric patient: an early sign for mosaic neurofibromatosis type 1. Br J Dermatol. 2020 Nov 10;: Authors: Zhang J, Qin W, Hua S, Li M, Tang Y, Yao Z Abstract The presentation of multiple café au lait macules (CALMs) in children is a common reason for referral to a dermatologist. Segmental CALMs, a subtype of CALMs, are usually limited to a specific part of the body. Mosaic neurofibromatosis type 1 (NF1; OMIM #162200) is a common congenital disorder associated with segmental CALMs. It has an incidence of about one ...
Source: The British Journal of Dermatology - November 10, 2020 Category: Dermatology Authors: Zhang J, Qin W, Hua S, Li M, Tang Y, Yao Z Tags: Br J Dermatol Source Type: research

Patient-oriented outcomes for atopic dermatitis.
PMID: 33161565 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 8, 2020 Category: Dermatology Authors: Vazquez T, Concha JSS, Werth VP Tags: Br J Dermatol Source Type: research

Long-term safety of dupilumab in children.
PMID: 33161566 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 8, 2020 Category: Dermatology Authors: Sibbald C Tags: Br J Dermatol Source Type: research

Transforming growth factor- β messaging: #ContextMatters.
Transforming growth factor-β messaging: #ContextMatters. Br J Dermatol. 2020 Nov 08;: Authors: Guttmann-Gruber C, Piñón Hofbauer J PMID: 33161569 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 8, 2020 Category: Dermatology Authors: Guttmann-Gruber C, Piñón Hofbauer J Tags: Br J Dermatol Source Type: research

Identification of keratinocyte subpopulations in transcriptome to evaluate drug effects in atopic dermatitis.
PMID: 33161575 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 8, 2020 Category: Dermatology Authors: Miyano T, Tanaka RJ Tags: Br J Dermatol Source Type: research

Enhanced expression of ACE2 in psoriatic skin and its upregulation in keratinocytes by interferon-gamma: Implication of inflammatory milieu in skin tropism of SARS-CoV-2.
Abstract The novel coronavirus disease (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is a challenging situation globally due to its contagion nature. SARS-CoV-2 enters the host cell by interacting with the ACE2 (angiotensin converting enzyme 2) receptor present on cell surface through its receptor-binding domain (RBD) of spike protein (1). Host proteases mainly TMPRSS2 plays a vital role in cleaving the SARS-CoV-2 spike protein thereby enabling the virus to enter host cell via endocytosis. SARS-CoV-2 mainly affects the respiratory system of the infected host, however, i...
Source: The British Journal of Dermatology - November 6, 2020 Category: Dermatology Authors: Tembhre MK, Parihar AS, Sharma VK, Imran S, Bhari N, Lakshmy R, Bhalla A Tags: Br J Dermatol Source Type: research

The importance of assessing blood tumour burden in cutaneous T-cell lymphoma.
Abstract Mycosis fungoides (MF) and Sézary syndrome (SS) are the best studied subtypes of cutaneous T-cell lymphoma, and the level of blood tumour burden in patients is important for diagnosis, disease staging, prognosis and management, as well as in assessing treatment response. Until recently, the assessment of blood involvement was made using manual counts of morphologically atypical T cells (Sézary cells), but this approach may be subjective, and is affected by interobserver variability. Objective and consistent approaches to accurately quantifying blood involvement are required to ensure appropr...
Source: The British Journal of Dermatology - November 6, 2020 Category: Dermatology Authors: Vermeer MH, Nicolay JP, Scarisbrick JJ, Zinzani PL Tags: Br J Dermatol Source Type: research

Response to "Reduction in skin cancer diagnosis, and overall cancer referrals, during the COVID-19 pandemic".
Response to "Reduction in skin cancer diagnosis, and overall cancer referrals, during the COVID-19 pandemic". Br J Dermatol. 2020 Nov 05;: Authors: Murray G, Roche D, Ridge A, Hackett C, Tobin AM Abstract we noted with interest the recent letter by Earnshaw and colleagues documenting decreased skin cancer referrals to their dermatology department and report a similar phenomenon seen in Ireland on a national level1 . An analysis of skin cancer referrals from the National Cancer Control Programme (NCCP) Ireland from January to June in 2019 and 2020 showed that between the months of January to ...
Source: The British Journal of Dermatology - November 5, 2020 Category: Dermatology Authors: Murray G, Roche D, Ridge A, Hackett C, Tobin AM Tags: Br J Dermatol Source Type: research

Assessment of Familial Risk in Patients with Hidradenitis Suppurativa.
This study's aim was to quantify familial risk in patients with HS. PMID: 33152101 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 5, 2020 Category: Dermatology Authors: Bruinsma RL, Fajgenbaum K, Yang Y, Del Mar Melendez-Gonzalez M, Mohlke KL, Li Y, Sayed C Tags: Br J Dermatol Source Type: research

Long non-coding RNA MALAT1 suppresses miR-211 to confer protection from UV-mediated DNA damage in vitiligo epidermis by upregulating SIRT1.
CONCLUSION: These findings establish a novel MALAT1-miR-211-SIRT1 signaling axis that potentially confers protection to the 'amelanotic' keratinocytes in vitiligo. PMID: 33152110 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 5, 2020 Category: Dermatology Authors: Brahmbhatt HD, Gupta R, Gupta A, Rastogi S, Misri R, Mobeen A, Ghosh A, Kothari P, Sitaniya S, Scaria V, Singh A Tags: Br J Dermatol Source Type: research

Quality of life, treatment goals, preferences and satisfaction in older adults with psoriasis: a patient survey comparing age groups.
Abstract Psoriasis management in the rapidly expanding geriatric population can be complex due to frailty, comorbidities, comedication and limited available data on treating older psoriasis patients.1 Previous studies reported comparable disease severity in patients ≥65 years old (≥65yo) and patients
Source: The British Journal of Dermatology - November 5, 2020 Category: Dermatology Authors: van Winden MEC, Ter Haar ELM, Groenewoud JMM, van de Kerkhof PCM, de Jong EMGJ, Lubeek SFK Tags: Br J Dermatol Source Type: research

Environmental Sustainability in Dermatological Surgery.
This article discusses a range of behavioural, procedural and structural interventions, which could help minimise the environmental impact of dermatologic surgery, categorised according to the 5 R's: Reduce, Reuse, Recycle, Rethink and Research. PMID: 33152116 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 5, 2020 Category: Dermatology Authors: Chaplin CL, Wernham AGH, Veitch D Tags: Br J Dermatol Source Type: research

British Association of Dermatologists guidelines for the management of people with cutaneous squamous cell carcinoma 2020.
ts’ Clinical Standards Unit Abstract The overall objective of the guideline is to provide up-to-date, evidence-based recommendations for the management of cutaneous squamous cell carcinoma (cSCC). The document aims to: offer an appraisal of all relevant literature up to 30th January 2020, focusing on any key developments address important, practical clinical questions relating to the primary guideline objective. provide guideline recommendations and if appropriate research recommendations. PMID: 33150585 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 4, 2020 Category: Dermatology Authors: Keohane SG, Botting J, Budny PG, Dolan OM, Fife K, Harwood CA, Mallipeddi R, Marsden JR, Motley RJ, Newlands C, Proby C, Rembielak A, Slater DN, Smithson JA, Buckley P, Fairbrother P, Hashme M, Mohd Mustapa MF, Exton LS, British Association of Dermatologi Tags: Br J Dermatol Source Type: research

Oral vesiculobullous lesions as an early sign of COVID-19: immunohistochemical detection of SARS-CoV-2 spike protein.
PMID: 33140407 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 2, 2020 Category: Dermatology Authors: Soares CD, Mosqueda-Taylor A, de Carvalho MGF, de Almeida OP Tags: Br J Dermatol Source Type: research

Hidradenitis suppurativa associated with actinomycosis owing to Actinomyces meyeri.
D, Mercadillo-Pérez P PMID: 33140414 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 2, 2020 Category: Dermatology Authors: Bonifaz A, Fernández-Samar D, Tirado-Sánchez A, Vázquez-González D, Mercadillo-Pérez P Tags: Br J Dermatol Source Type: research

Which method is better for the diagnosis of basal cell carcinoma: biopsy vs. reflectance confocal microscopy?
PMID: 33140421 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 2, 2020 Category: Dermatology Authors: Patalay R Tags: Br J Dermatol Source Type: research

Cydnidae pigmentation: unusual location on the abdomen and back.
PMID: 33140425 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 2, 2020 Category: Dermatology Authors: Amrani A, Das A Tags: Br J Dermatol Source Type: research

PRAME immunohistochemistry as an adjunct in the diagnosis of paucicellular lentigo maligna in a young man.
PMID: 33140433 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 2, 2020 Category: Dermatology Authors: Agrawal R, Tso S, Eltigani EA, Busam KJ, Taibjee SM, Carr RA Tags: Br J Dermatol Source Type: research

Dermatofibrosarcoma protuberans: slowly gathering evidence for optimal treatment of a slow-growing tumour.
PMID: 33140441 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 2, 2020 Category: Dermatology Authors: van den Bos RR Tags: Br J Dermatol Source Type: research

Dermatological education for the 21st century: prioritizing diversity.
Abstract All education, including medical education, reflects society's trends and needs. Skin and skin pigmentation have both personal and societal effects on an individual. During the protests following the killing of George Floyd in the United States and worldwide, there has been a large-scale, united drive to acknowledge and establish a strong resolve against systematic racism and its insidious and lasting effects, including economic exclusion, academic and scientific marginalization, and health disparities. PMID: 33135167 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 1, 2020 Category: Dermatology Authors: Burgin S, Dlova NC, Goldsmith LA Tags: Br J Dermatol Source Type: research

Measurement properties of the Patient-Reported Outcomes Information System (PROMIS ® ) Itch Questionnaire: itch severity assessments in adults with atopic dermatitis.
In this study, we set out to determine the measurement properties of the Patient-Reported Outcomes Information System (PROMIS® ) Itch Questionnaire (PIQ) itch severity assessment, including multiple NRS, VRS and frequency of itch assessments in adults with AD. We evaluated a group of 410 adults with AD who were patients at an academic medical center. We measured AD severity using multiple self and clinician-assessments. We used the PIQ itch severity scales to assess their itch severity. PIQ NRS, VRS and frequency of itch had good content validity (i.e. made sense to patients and were relevant to patient-experience in A...
Source: The British Journal of Dermatology - November 1, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

New Clinical Trials Associate Editor: Emilie Sbidian.
Authors: PMID: 33135790 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 1, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

The value of case reports in pharmacovigilance.
PMID: 33135791 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 1, 2020 Category: Dermatology Authors: Garcia-Doval I, Segovia E, Hunter H, Frew J, Naldi L Tags: Br J Dermatol Source Type: research

November 2020 John Ingram.
Authors: PMID: 33135792 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 1, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

Erratum.
Authors: PMID: 33135793 [PubMed] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 1, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

Corrigendum.
Authors: PMID: 33135794 [PubMed] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - November 1, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

Occupational dermatoses during the Covid-19 pandemic: a multicentre audit in the UK and Ireland.
Abstract During the Covid-19 pandemic, with the increased need for donning personal protective equipment (PPE) and frequent handwashing, we have noted growing reports from at home and abroad of high rates of irritant dermatitis in frontline healthcare workers (HCWs). In China, where the SARS Cov-2 virus was first reported, up to 97% of frontline HCWs reported skin changes related to new infection control practices.1,2 A recent study of 146 HCWs from Manchester and London diagnosed irritant contact dermatitis (ICD) in 97.1%, with high rates of pressure-related facial dermatitis from masks and goggles. PMID: 33...
Source: The British Journal of Dermatology - October 28, 2020 Category: Dermatology Authors: O'Neill H, Narang I, Buckley DA, Phillips TA, Bertram CG, Bleiker TO, Chowdhury MMU, Cooper SM, Abdul Ghaffar S, Johnston GA, Kiely LF, Sansom JE, Stone N, Thompson DA, Banerjee P Tags: Br J Dermatol Source Type: research

Caf é-au-lait macules overlying segmental macular hyperpigmentation in a pediatric patient: an early sign for mosaic neurofibromatosis type 1.
Café-au-lait macules overlying segmental macular hyperpigmentation in a pediatric patient: an early sign for mosaic neurofibromatosis type 1. Br J Dermatol. 2020 Oct 28;: Authors: Zhang J, Qin W, Hua S, Li M, Tang Y, Yao Z Abstract The presentation of multiple café-au-lait macules (CALMs) in children is a common reason for referral to a dermatologist. Segmental CALMs, a subtype of CALMs, is usually limited to a specific part of the body. Mosaic neurofibromatosis type 1 (NF1; OMIM 162200) is a common congenital disorder associated with segmental CALMs with an incidence of about 1 case/400...
Source: The British Journal of Dermatology - October 28, 2020 Category: Dermatology Authors: Zhang J, Qin W, Hua S, Li M, Tang Y, Yao Z Tags: Br J Dermatol Source Type: research

Quality Assurance and Characterisation of NB-UVB Devices for use at home - Lessons from the Hi-Light Vitiligo Trial.
Abstract Hand-held narrowband UVB (NB-UVB) devices are available for the treatment of various skin conditions, but their optical radiation omissions are often not thoroughly characterised. Following a pilot study1 that identified potential dosimetry issues, we separately characterised, and quality controlled all devices issued to participants in the main Home Interventions and Light Therapy for the treatment of Vitiligo [Hi-Light] Trial2,3,4 [ISRCTN 17160087]. PMID: 33107975 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 27, 2020 Category: Dermatology Authors: Rogers A, Akram P, Batchelor JM, Crutchley J, Grocki M, Haines RH, Meakin G, O'Dowd K, Ravenscroft J, Thomas KS Tags: Br J Dermatol Source Type: research

Real-world effectiveness and tolerability of dupilumab in adult atopic dermatitis: A single centre, prospective one-year observational cohort study of the first 100 patients treated.
We report comprehensive outcome data at one year for the first 100 adult patients initiated on dupilumab in a specialist eczema clinic (May 2017-November 2019). In this prospective, observational cohort study (HRA UK ref.268527) all patients received dupilumab at licenced dose. Wherever possible, patients on other systemic treatment(s) underwent 4-week washout prior to dupilumab. All patients were given preservative-free lubricating eye ointment prior to dupilumab in view of ophthalmic complications reported in trials1-3 . Disease activity and patient-reported outcome measures were assessed at baseline, week 12, week 24 an...
Source: The British Journal of Dermatology - October 27, 2020 Category: Dermatology Authors: Sears AV, Woolf RT, Gribaleva E, Abdelrahman W, Robbie S, Menon B, Kirkham B, Smith CH, Pink AE Tags: Br J Dermatol Source Type: research

Prurigo pigmentosa and new-onset type 1 diabetes in a black female patient testing positive for SARS-CoV-2 IgG.
PMID: 33103238 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 25, 2020 Category: Dermatology Authors: Derrick KM, Mazori DR, Heilman ER, Glick SA Tags: Br J Dermatol Source Type: research

Second primary cutaneous melanoma in patients with advanced melanoma treated with anti-PD-1 monoclonal antibodies.
ano E Abstract Cases of second primary cutaneous melanoma (SPCM), which were mostly BRAF-wild type, have been reported in BRAF-inhibitor-treated advanced cutaneous melanoma patients.1 Anti-programmed-death-receptor-1 (anti-PD-1) monoclonal antibodies (mAb) nivolumab and pembrolizumab have also revolutionized the prognosis of these patients, but 10-15% of them experience grade 3-4 adverse events according to Common Terminology Criteria for Adverse Events The risk of developing a SPCM in this population has not been reported and could be reduced by anti-PD-1 treatment. PMID: 33098566 [PubMed - as supplied by pu...
Source: The British Journal of Dermatology - October 24, 2020 Category: Dermatology Authors: Charvet E, Kramkimel N, Chaplain L, Gantzer A, Kassem O, Longvert C, Blom A, Dupin N, Aractingi S, Hamon M, Zimmermann U, Emile JF, Sohier P, Sidibé T, Saiag P, Funck-Brentano E Tags: Br J Dermatol Source Type: research

Hidradenitis Suppurativa and perceived stigmatization in a diverse Canadian clinic population: A pilot study.
Abstract Hidradenitis suppurativa (HS) is a chronic inflammatory skin disorder with painful inflamed nodules and tunnels in the intertriginous areas.1 The burden of HS extends beyond the physical symptoms with increased rates of depression and completed suicide reported.2 More recently, HS has been linked to greater feelings of stigmatization, 3 which may be attributed to the disfiguring skin manifestations and boil-like nature of the lesions. PMID: 33095910 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 23, 2020 Category: Dermatology Authors: Bouazzi D, McPhie ML, Kjaersgaard Andersen R, Alavi A, Jemec GBE Tags: Br J Dermatol Source Type: research

An additional drug repurposing study for hidradenitis suppurativa/acne inversa.
Abstract Current transcriptome and proteome studies have identified differentially regulated genes and proteins in hidradenitis suppurativa/acne inversa (HS), both in entire involved skin1 and in involved skin apocrine glands.2 Such studies may provide relevant data for identification of druggable molecular targets leading to novel therapeutic compounds or repurposing of already registered drugs in HS. Indeed, computational drug repurposing screening methods using DNA microarray datasets have already been used to identify existing compounds as potential drugs for targeted diseases, including dermatologic condition...
Source: The British Journal of Dermatology - October 23, 2020 Category: Dermatology Authors: Zouboulis CC, Readhead B, Dudley JT Tags: Br J Dermatol Source Type: research

Identifying the required degree of disease clearance to improve quality of life in pemphigus vulgaris.
Abstract With the increase in pemphigus vulgaris (PV) clinical trials and treatments, it is imperative to establish validated outcome measures. Although prior studies have shown that quality of life (QoL) improves when disease severity decreases, it is unknown whether partial clearance (e.g. in dermatomyositis or systemic lupus erythematosus) or complete clearance (e.g. in psoriasis) is necessary to achieve maximal QoL. For PV, we seek to identify whether there is a specific cut-off point at which further improvement in disease activity does not improve QoL, or whether complete skin clearance is required to achiev...
Source: The British Journal of Dermatology - October 22, 2020 Category: Dermatology Authors: Bax CE, Ravishankar A, Yan D, Concha J, Kushner CJ, Zamalin D, Feng R, Payne AS, Werth VP Tags: Br J Dermatol Source Type: research

Association between atopic dermatitis and autoimmune diseases: a population-based case-control study.
CONCLUSION: This large population-based study indicates a significant autoimmune comorbidity of adults with AD, especially between AD and autoimmune dermatologic, gastrointestinal and rheumatologic diseases. Having multiple autoimmune diseases had a stronger association with AD than having only one autoimmune disease. PMID: 33091150 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 22, 2020 Category: Dermatology Authors: Ivert LU, Wahlgren CF, Lindelöf B, Dal H, Bradley M, Johansson EK Tags: Br J Dermatol Source Type: research

Actinomycetoma caused by Nocardia asiatica associated with traditional Chinese medicine foot bath.
PMID: 33089495 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 21, 2020 Category: Dermatology Authors: Ma Y, Zhao C, Li R, Wang X Tags: Br J Dermatol Source Type: research

Exploring patient-physician trust dynamics in patients with psychocutaneous and general dermatological disease.
Abstract Patient-physician trust is a key factor in achieving compliance and higher satisfaction rates of medical care. [1,2] Research has shown that managing patients with psychodermatological disease, can be challenging due to their negative attitudes towards healthcare professionals. PMID: 33084024 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 21, 2020 Category: Dermatology Authors: Stavrou PZ, Gkini MA, Taylor R, Bewley A Tags: Br J Dermatol Source Type: research

A changed life: the life experiences of patients with psoriasis receiving biological treatment.
Abstract We read with interest the Original Article by Trettin et al., examining the life-changing impact of biological therapies on patients with psoriasis (1). As they have demonstrated, the long-term psychological sequelae of psoriasis cannot be under-estimated, even after successful treatment with biologic therapy. PMID: 33084027 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 21, 2020 Category: Dermatology Authors: Maruthappu T, Bewley A Tags: Br J Dermatol Source Type: research

The climate emergency: why should dermatologists care, and how can they act?
Abstract Weather and climate exist on a massive scale: over the last 650,000 years, only seven glacial cycles have occurred. The end of the last ice age 12,000 years ago marked the beginning of modern civilization - since then, an estimated 400 generations have passed. Yet it is only since the 1950s that greenhouse gas concentrations and global surface, atmospheric, and ocean temperatures have climbed to their highest levels in millennia, destabilizing climate systems and causing extreme weather events. PMID: 33067798 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 17, 2020 Category: Dermatology Authors: Sun M, Rosenbach M Tags: Br J Dermatol Source Type: research

International validation of the Bullous Pemphigoid Disease Area Index (BPDAI) severity score and calculation of cut-off values for defining mild, moderate and severe type of bullous pemphigoid.
e bullous skin disease task force of the EADV Abstract BACKGROUND: The Bullous-Pemphigoid-Disease-Area-Index (BPDAI) score has been proposed to provide an objective measure of bullous pemphigoid (BP) activity. OBJECTIVE: To calculate BPDAI cut-off values defining mild, moderate and severe BP, and to assess the inter-rater reliability, and the correlation with the number of daily new blisters, and anti-BP180 and anti-BP230 antibodies. METHODS: Severity scores were recorded by two blinded investigators. Anti-BP180 and anti-BP230 antibodies were measured using an ELISA assay. Cut-off values defining mild, m...
Source: The British Journal of Dermatology - October 17, 2020 Category: Dermatology Authors: Masmoudi W, Vaillant M, Vassileva S, Patsatsi A, Quereux G, Moltrasio C, Abasq C, Prost-Squarcioni C, Kottler D, Kiritsi D, Litrowski N, Plantin P, Friedrichsen L, Zebrowska A, Duvert-Lehembre S, Hofmann S, Ferranti V, Jouen F, Joly P, Hebert V, auto immu Tags: Br J Dermatol Source Type: research

Motives for intentional sunlight exposure among young adult sexual minority men: appearance, relaxation, and socialization in a cohort study.
Abstract Lifetime skin cancer prevalence is 25% higher among gay men and 46% higher among bisexual men compared to heterosexual men, making sexual minority men (SMM) an at-risk group for skin cancer.1 These elevated skin cancer rates may be attributed in part to indoor tanning among SMM, some of whom are motivated to indoor tan by perceived body image standards, appearance concerns, and affect regulation.2. PMID: 33067803 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 16, 2020 Category: Dermatology Authors: Robinson JK, Wahood S, Stapleton JL Tags: Br J Dermatol Source Type: research