Intralesional rituximab in the treatment of indolent primary cutaneous B-cell lymphoma.
Abstract Primary cutaneous B-cell lymphomas (PCBCLs) are a heterogeneous group of extranodal lymphomas1 . Primary cutaneous marginal zone lymphoma (MZL) and follicle center lymphoma (FCL), the most prevalent PCBCLs, are typically indolent. PMID: 32798319 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 14, 2020 Category: Dermatology Authors: Chirico A, Henderson Berg MH, Roberge D, Pehr K Tags: Br J Dermatol Source Type: research

Identification of proteins associated with development of metastasis from cutaneous squamous cell carcinomas (cSCCs) via proteomic analysis of primary cSCCs.
CONCLUSIONS: This study highlights that increased expression of two proteins, ANXA5 and DDOST, is significantly associated with poorer clinical outcomes in cSCC. PMID: 32794257 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 12, 2020 Category: Dermatology Authors: Shapanis A, Lai C, Smith S, Coltart G, Sommerlad M, Schofield J, Parkinson E, Skipp P, Healy E Tags: Br J Dermatol Source Type: research

Autosomal recessive hypotrichosis with loose anagen hairs associated with TKFC mutations.
CONCLUSIONS: TKFC missense mutations may predispose to the development of loose anagen hairs. Identification of this new biochemical pathobiology expands the metabolic and genetic basis of hypotrichosis. PMID: 32790068 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 12, 2020 Category: Dermatology Authors: Onoufriadis A, Cabezas A, Ng JCFF, Canales J, Costas MJ, Ribeiro JM, Rodrigues JR, McAleer MAA, Castelo-Soccio L, Simpson MAA, Fraternali F, Irvine ADD, Cameselle JC, McGrath JAA Tags: Br J Dermatol Source Type: research

Negative tests for SARS-CoV-2 infection do not rule out its responsibility for chilblains.
Abstract We read with great interest the report of Le Cleach et al discussing chilblains as a manifestation of COVID-19 pandemic. They reported 311 patients with acral lesions occurring during the COVID-19 lockdown in France. The most frequent clinical presentation of these acral lesions was typical chilblains. Among the 150 patients with RT-PCR testing and/or serology, only 10 had confirmed COVID-19. They concluded that there is no evidence of SARS-CoV-2 infection in the large majority of patients with acral lesions. They hypothesized that the situation could be due to the media stating that chilbl...
Source: The British Journal of Dermatology - August 12, 2020 Category: Dermatology Authors: Battesti G, Descamps Vincent V Tags: Br J Dermatol Source Type: research

Co-Reactivation of Human Herpesvirus alpha Subfamily (HSV Ⅰ and VZV) in Critically Ill Patient with COVID-19.
We report a first case of COVID-19 with reactivation of human herpesvirus (HHV) alpha subfamily (herpes simplex virus I [HSV Ⅰ] and varicella-zoster virus [VZV]). Due to the immunosuppressive state associated with COVID-19, infection of the HHV alpha subfamily (HSV Ⅰ and VZV) could be potentially life threatening. PMID: 32790074 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 12, 2020 Category: Dermatology Authors: Xu R, Zhou Y, Cai L, Wang L, Han J, Yang X, Chen J, Chen J, Ma C, Shen L Tags: Br J Dermatol Source Type: research

Occupational Dermatology in the time of the Covid-19 pandemic: A report of experience from London and Manchester, United Kingdom.
Abstract The Covid-19 pandemic has resulted in healthcare systems responding to rapidly rising demand. Simultaneously, increased infection prevention measures for staff, which includes additional personal protective equipment (PPE) and more rigorous hand hygiene procedures, has resulted in an increased incidence of occupational skin disease in frontline staff (1). PMID: 32790187 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 12, 2020 Category: Dermatology Authors: Ferguson FJ, Street G, Cunningham L, White IR, McFadden JP, Williams J Tags: Br J Dermatol Source Type: research

Negative tests for SARS-CoV-2 infection do not rule out its responsibility for chilblains: reply from authors.
Abstract With great interest, we read Battesti and Descamps comment on our recently published study in this journal. Their comment is based on their findings that histological and immunostaining of skin biopsy of 7 cases of "epidemic chilblains" with negative SARS-CoV-2 RT-PCR and repeated serology was similar to those of a historical series of 11 cases of chilblains lupus notably for high expression of CD123 and MxA a type-I interferon (IFN-I)-induced protein in both groups1 . PMID: 32790922 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 12, 2020 Category: Dermatology Authors: Le Cleach L, Fourati S, Sbidian E, Beylot-Barry M Tags: Br J Dermatol Source Type: research

Tight junctions in the skin: still a lot to learn.
PMID: 32776623 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 9, 2020 Category: Dermatology Authors: De Benedetto A Tags: Br J Dermatol Source Type: research

Reviewing the Global Burden of acne: how could we improve care to reduce the burden?
Abstract Acne (syn: acne vulgaris) remains the commonest inflammatory dermatosis treated worldwide as estimated by global skin disease prevalence studies. Latest reports suggest the prevalence may be increasing in adolescents and adults, particularly adult females. The concept of burden of skin disease is multidimensional and can be difficult to quantify in light of different healthcare systems across the globe. In acne, the resulting burden may vary according to the patient demographic, access to treatments and duration of the disease. The visible nature of acne, symptoms and sequelae all contribute physically an...
Source: The British Journal of Dermatology - August 7, 2020 Category: Dermatology Authors: Layton AM, Thiboutot D, Tan J Tags: Br J Dermatol Source Type: research

Recurrent MVD mutation in European patients with disseminated porokeratosis.
, Has C Abstract Porokeratosis (PK) comprises clinically and genetically heterogeneous disorders of keratinisation. They manifest with marginate scaling lesions, histologically showing a column of parakeratotic keratinocytes, the cornoid lamella. Porokeratotic conditions were historically classified into several clinical forms based on distribution and morphology of the lesions, e.g. disseminated porokeratoses, porokeratosis of Mibelli, giant porokeratosis, palmoplantar porokeratosis Mantoux and linear porokeratosis. PMID: 32767669 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 6, 2020 Category: Dermatology Authors: Saleva-Stateva M, Technau-Hafsi K, Frommherz L, Grüninger G, Jägle S, Dourmishev L, Miteva L, Fischer J, Has C Tags: Br J Dermatol Source Type: research

Transient response to nivolumab and relapse after infliximab in a patient with primary cutaneous CD8-positive aggressive epidermotropic cytotoxic T-cell lymphoma.
We report the case of a 70-year old female patient who presented with a red plaque with central ulceration on the left shin rapidly developing in two weeks. PMID: 32767675 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 6, 2020 Category: Dermatology Authors: Toussaint F, Erdmann M, Grosch E, Schliep S, Schuler G, Dummer R, Heinzerling L Tags: Br J Dermatol Source Type: research

Non-invasive assessment of cytokine and antimicrobial peptide levels in Hidradenitis Suppurativa using transdermal analysis patches.
Abstract Most of the currently available cytokine and antimicrobial peptide (AMP) expression data from Hidradenitis suppurativa (HS) lesions have been obtained through painful, invasive sampling techniques such as biopsies.1 In contrast, a Transdermal Analysis Patch (TAP, FibroTx, Tallinn, Estonia) captures and measures biomarkers at the skin surface and as such represents a novel, non-invasive, and patient-friendly diagnostic tool for skin biomarker detection. The aim of this study was to measure the levels of several cytokines and AMPs in both lesional and uninvolved skin of HS patients and site-matched skin of ...
Source: The British Journal of Dermatology - August 6, 2020 Category: Dermatology Authors: Ardon CB, Wang C, Prens EP, van Straalen KR Tags: Br J Dermatol Source Type: research

A review of current phase III clinical trials of plaque psoriasis: Underrepresentation of non-white subjects and need for reform.
Abstract Plaque psoriasis is a chronic inflammatory skin condition that affects an estimated 0.91% to 8.5% of the global population.1 The prevalence of psoriasis varies based on ethnoracial and geographic distribution. In the United States, psoriasis affects approximately 3.6% of Caucasians (non-Hispanic white), 1.9% of African Americans (non-Hispanic black), and 1.6% of Hispanic-identifying adults.2 Population-based studies in East and Southeast Asia have estimated a prevalence ranging from 0.05 to 0.47%.3. PMID: 32767747 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 6, 2020 Category: Dermatology Authors: Reddy VD, Myers BA, Chan SY, Thibodeaux QG, Brownstone ND, Bhutani T, Liao W, Lester JC, Koo JY Tags: Br J Dermatol Source Type: research

Loss of Laminin α3 induces cell invasion and macrophage infiltration in cutaneous squamous cell carcinoma.
CONCLUSIONS: These data provide evidence that loss of the laminin α3 chain in cSCC has an effect on both the epithelial and immune components of cSCC resulting in an aggressive tumour microenvironment. PMID: 32767748 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 6, 2020 Category: Dermatology Authors: Caley MP, Martins VL, Moore K, Lashari M, Nissinen L, Kähäri VM, Alexander S, Jones E, Harwood CA, Jones J, Donaldson M, Marshall JF, O'Toole EA Tags: Br J Dermatol Source Type: research

Response to 'The incidence and survival of melanoma and nonmelanoma skin cancer in patients with vitiligo: a nationwide population-based matched cohort study in Korea': reply from authors.
Abstract It is technically impossible to ascertain cumulative UVR exposure with the Korean National Health Insurance claims database due to the lack of information on each treatment dose. As an alternative, we stratified our patients based on the number of phototherapy sessions (no phototherapy,
Source: The British Journal of Dermatology - August 6, 2020 Category: Dermatology Authors: Kim HS, Ahn HS Tags: Br J Dermatol Source Type: research

Nail fold capillary abnormalities: a possible cause for nail psoriasis?
Abstract Digital video nailfold capillaroscopy (DVNC) is an efficient and noninvasive technique for the evaluation of local microcirculation, which has been widely used in the diagnosis and prediction of several kinds of connective tissue diseases. To this day, reports on the changes of the nail fold capillaries (NFC) in patients with psoriasis vulgaris (PV) accompanied with nail involved are scarce and the existing data are not conclusive. Using DVNC, we found that NFC abnormalities may relate to nail psoriasis (NP). PMID: 32767750 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 6, 2020 Category: Dermatology Authors: Long F, He F, Wang J, Wang L, Tu J, Zhang Z, Xia J, Lu Y, Yin Z Tags: Br J Dermatol Source Type: research

Increased expression of IL-23A in lesional skin of atopic dermatitis patients with psoriasiform reaction during dupilumab treatment.
Abstract Atopic dermatitis (AD) and psoriasis (Pso) are chronic diseases that may be phenotypes at polar ends of the T-cell inflammatory milieu. The two diseases represent two distinct pathogenetic entities, with type 2 T helper (Th2) cytokines interleukin (IL)-4, IL-13, IL-31, and possibly IL-22 mainly implicated in AD, and Th17 cytokines IL-17 and IL-23 in Pso.3 However, a range of phenotypes with overlapping clinical patterns exist, possibly reflecting a variable expression of T-cell axes. Dupilumab is a human monoclonal antibody directed against the alpha subunit of IL-4 receptor, approved for the treatment of...
Source: The British Journal of Dermatology - August 6, 2020 Category: Dermatology Authors: Napolitano M, Caiazzo G, Fabbrocini G, Balato A, Di Caprio R, Scala E, Scalvenzi M, Patruno C Tags: Br J Dermatol Source Type: research

Routine liver ultrasound screening does not alter clinical management in a cohort study of multiple cutaneous infantile haemangioma.
Abstract Cutaneous infantile haemangioma (IH) occurs in 5-10% of neonates, with multiple IH (>1) in 30% of those1 . Expert opinion currently recommends routine liver ultrasound(USS) for five or more(5+ ) IH2,3 , and if hepatic haemangiomas(HH) are identified, to test thyroid function3 even if neonatal thyroid screening occurred. Supportive data from one cohort demonstrate associations between 5+ IH and HH1 , and between HH and adverse clinical outcomes (cardiac failure/hypothyroidism)4-6 . PMID: 32767853 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 6, 2020 Category: Dermatology Authors: Mahon C, McHugh K, Alband N, Rampling D, Sebire N, Williamson E, Glover M, Kinsler VA Tags: Br J Dermatol Source Type: research

The limitations of case reports in professional development.
Abstract We read with interest two British Journal of Dermatology editorials that highlighted the positive role of case reports in the medical literature.1,2 Case scenarios are widely presented in hospital teaching sessions, and some universities build their curricula around 'case-based learning'. It facilitates clinical intuition through pattern recognition.1 This fosters a Bayesian approach, increasing the efficiency of diagnosis. PMID: 32767855 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 6, 2020 Category: Dermatology Authors: Yesudian R, Yesudian P, Yesudian PD Tags: Br J Dermatol Source Type: research

Increased expression of IL-23A in lesional skin of atopic dermatitis patients with psoriasiform reaction during dupilumab treatment.
Abstract Atopic dermatitis (AD) and psoriasis (Pso) are chronic diseases that may be phenotypes at polar ends of the T-cell inflammatory milieu.1,2 The two diseases represent two distinct pathogenetic entities, with type 2 T helper (Th2) cytokines interleukin (IL)-4, IL-13, IL-31, and possibly IL-22 mainly implicated in AD, and Th17 cytokines IL-17 and IL-23 in Pso.3 However, a range of phenotypes with overlapping clinical patterns exist, possibly reflecting a variable expression of T-cell axes. PMID: 32762038 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 5, 2020 Category: Dermatology Authors: Napolitano M, Caiazzo G, Fabbrocini G, Balato A, Di Caprio R, Scala E, Scalvenzi M, Patruno C Tags: Br J Dermatol Source Type: research

Exploring the human hair follicle microbiome.
aus R Abstract Human hair follicles (HF) carry complex microbial communities that differ from skin surface microbiota. This likely reflects that the HF epithelium differs from the epidermal barrier in that it provides a moist, less acidic, and relatively UV-protected environment, part of which is immune-privileged, thus facilitating microbial survival. Here we review the current understanding of the human HF microbiome and its potential physiological and pathological functions, including in folliculitis, acne vulgaris, hidradenitis suppurativa, alopecia areata and cicatricial alopecias. While reviewing the main hu...
Source: The British Journal of Dermatology - August 5, 2020 Category: Dermatology Authors: Lousada MB, Lachnit T, Edelkamp J, Rouillé T, Ajdic D, Uchida Y, Di Nardo A, Bosch TCG, Paus R Tags: Br J Dermatol Source Type: research

Quantification of skin sensitivity to ultraviolet radiation using ultra-wideband optoacoustic mesoscopy.
Abstract Phototesting is used to assess individual sensitivity to ultraviolet (UV) radiation in order to determine adequate UV dosage for phototherapy1 . In the standard procedure, small skin areas are exposed to increasing doses of UV radiation. The lowest UV dose that induces a delineated erythema at 24±2 h after UV exposure defines the minimal erythema dose (MED)2 . Visual assessment is the gold standard for MED determination; however, it is prone to observer variability3 . Optical methods have been considered to quantify the magnitude of erythema response. However, they are limited by light scattering t...
Source: The British Journal of Dermatology - August 5, 2020 Category: Dermatology Authors: Hindelang B, Aguirre J, Berezhnoi A, Biedermann T, Darsow U, Eberlein B, Ntziachristos V Tags: Br J Dermatol Source Type: research

Diagnosis of Mycoplasma aetiology in Stevens-Johnson Syndrome / Toxic Epidermal Necrolysis.
Abstract We were pleased that the first national guidelines for paediatric Stevens-Johnson Syndrome (SJS) / Toxic Epidermal Necrolysis (TEN) were published in your journal last year1 . They highlighted the higher rate of infectious triggers in children compared to adults. This message is especially important for us, as author SW's son had SJS/TEN triggered by Mycoplasma pneumoniae, which accounts for up to 50% of infectious causes. SW experienced first-hand the frustration of aetiological uncertainty in this disease. Accurate diagnosis of Mycoplasma-induced SJS/TEN is important as it allows for continuation of sim...
Source: The British Journal of Dermatology - August 4, 2020 Category: Dermatology Authors: Russell E, Walker S, McPherson T Tags: Br J Dermatol Source Type: research

Caffeine relaxes hair follicles in androgenetic alopecia.
PMID: 32740912 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 1, 2020 Category: Dermatology Authors: Ohyama M Tags: Br J Dermatol Source Type: research

Water hardness and a possible genetic link with eczema in children.
Authors: Abstract Previous studies have found a possible link between the risk of children developing atopic eczema, and hardness of the water used at home. The harder the water (containing more calcium), the more children seemed to develop eczema. Yet a study in children with eczema using water softeners to reduce water hardness had shown no difference in eczema severity. In this UK study, data was used from 1303 children who had participated in the Enquiring About Tolerance (EAT) study. The aim of that study was to investigate if food allergies can be prevented. The available data of these children was quite co...
Source: The British Journal of Dermatology - July 31, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

Editor's Choice.
Authors: PMID: 32740917 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 31, 2020 Category: Dermatology Tags: Br J Dermatol Source Type: research

Clinical trials in the BJD: reviewing the last decade and looking to the future.
PMID: 32740918 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 31, 2020 Category: Dermatology Authors: Batchelor JM Tags: Br J Dermatol Source Type: research

Omalizumab for the treatment of Chronic Inducible Urticaria in 80 patients.
dez Chico N, Giménez-Arnau A Abstract Recruited were 80 participants with conditions as follows: solar urticaria (n=27), cold urticaria (n=22), symptomatic dermographism (n=11), cholinergic urticaria (n=10), delayed pressure urticaria (n=7), aquagenic urticaria (n=2), and heat urticaria (n=1). To compare the therapeutic benefits for different CindU subtypes, we evaluated response to omalizumab 300mg/4w using the Urticaria Control Test (UCT),1 grouping patients according to response: complete response (UCT=16); satisfactory response (UCT≥12-15); and non-response (UCT4 months). We used omalizumab according...
Source: The British Journal of Dermatology - July 29, 2020 Category: Dermatology Authors: Exposito-Serrano V, Curto Barredo L, Aguilera Peiro P, Gómez Armayones S, Serra-Baldrich E, Spertino J, Bonfill Ortí M, Figueras Nart I, Melé-Ninot G, Baliu-Piqué C, Sala Cunill A, Labrador M, Guilabert Vidal A, Fernández Chico N, Giménez-Arnau A Tags: Br J Dermatol Source Type: research

Evaluation of 'Not relevant' responses on the DLQI, and the DLQI-R scoring modification among Indian patients with vitiligo.
Abstract It has been suggested that the 'Not relevant' responses (NRRs) in Dermatology Life Quality Index (DLQI) may lead to underestimation of disease burden. PMID: 32730641 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 29, 2020 Category: Dermatology Authors: Gupta V, Taneja N, Sati HC, Sreenivas V, Ramam M Tags: Br J Dermatol Source Type: research

Disparities in Outcomes of CD8+ Cutaneous T Cell Lymphoma by Race and Presenting Lesion Location.
Abstract While cutaneous T-cell lymphoma (CTCL) presents most commonly with a CD4+ phenotype, CD8+ and CD30+ variants have also been described. CD8+ variants include primary cutaneous epidermotropic cytotoxic T-cell lymphoma, subcutaneous panniculitis-like T-cell lymphoma, cutaneous CD8+ lymphomas associated with immunodeficiency, and CD8+ variants of other well-defined CTCLs1 . While the epidemiology of other CTCLs has been well described, there remains a dearth of literature characterizing the incidence and survival patterns of CD8+ CTCL2 . Thus, we aimed to better characterize data on US national epidemiologic ...
Source: The British Journal of Dermatology - July 29, 2020 Category: Dermatology Authors: Mirza FN, Yumeen S, Girardi M Tags: Br J Dermatol Source Type: research

Drug survival of systemic and biologic treatments for moderate-to-severe atopic dermatitis in adults: a multicenter retrospective observational study.
rio-Hita JC Abstract Drug survival is a real-life reflection of drug performance in routine medical practice and measures the patient's persistence under a given treatment. Survival of systemic treatment of atopic dermatitis (AD) has been evaluated in previous analyses in routine clinical practice. Recently, dupilumab, a fully human monoclonal antibody that targets the IL-4 receptor α, has been approved for the treatment of moderate to severe AD. PMID: 32730674 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 29, 2020 Category: Dermatology Authors: Pereyra-Rodriguez JJ, Domínguez-Cruz J, Ruiz-Villaverde R, Silvestre JF, Galán M, Curto L, Figueras I, Serra-Baldrich E, Armario-Hita JC Tags: Br J Dermatol Source Type: research

Machine learning applied to atopic dermatitis transcriptome reveals distinct therapy-dependent modification of the keratinocyte immunophenotype.
CONCLUSION: Our analysis of transcriptomic signatures in cutaneous disease biopsies reveals the effect of keratinocyte programming in skin inflammation and suggests that the perturbation of a single axis of immune signal alone may be insufficient to resolve keratinocyte immunophenotype abnormalities. PMID: 32730675 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 29, 2020 Category: Dermatology Authors: Clayton K, Vallejo A, Sirvent S, Davies J, Porter G, Reading IC, Lim F, Ardern-Jones MR, Polak ME Tags: Br J Dermatol Source Type: research

Cutaneous signs in SARS CoV-2 infection: A plea for more rigorous peer-review in the time of COVID-19.
Abstract Many systemic viral infections are accompanied by skin rashes of variable morphology, some of them pathognomonic for the respective disease. Limited information is available about cutaneous signs in the course of SARS CoV-2 infection. Anecdotal observations and small case series collected from all over the globe have described a plethora of skin signs including, among others, Dengue-like, urticarial, crusted and papular, herpetiform and varicella-like rashes, and chillblain-like lesions ("COVID-toes"). PMID: 32730677 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 29, 2020 Category: Dermatology Authors: Kittler H, Tschandl P, Weninger W Tags: Br J Dermatol Source Type: research

The reliability of the self-assessment cutaneous inflammatory disease extent score (SA-CIDES) and the rule of hands to assess the involved body surface area in psoriasis and eczema.
Abstract It is largely unknown how reliable patients with psoriasis and eczema can estimate their involved body surface area (BSA). Nonetheless, this calculation is important for the development of patient-reported outcome measures (PROMs). The current standards remain the rule of hands (= 1 hand palm surface area equals 1% BSA) and the rule of nines (= chart with body sections that represent 9% of the BSA). Despite being around for 30 years, these methods have not been extensively validated when used by patients with skin disorders. PMID: 32730683 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 29, 2020 Category: Dermatology Authors: Speeckaert R, Lambert J, Delbaere L, Lesseliers T, van Geel N Tags: Br J Dermatol Source Type: research

Extent of ulceration in cutaneous melanoma: is this biomarker ready for primetime?
PMID: 32729117 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 28, 2020 Category: Dermatology Authors: Wilkinson MJ, Gyorki DE Tags: Br J Dermatol Source Type: research

A call for antifungal stewardship.
PMID: 32729125 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 28, 2020 Category: Dermatology Authors: Elewski B Tags: Br J Dermatol Source Type: research

Heterogeneous addiction to TGF β signalling in recessive dystrophic epidermolysis bullosa associated cutaneous squamous cell carcinoma.
CONCLUSION: Targeting TGFBR1 kinase activity may have therapeutic benefit in the majority of RDEB cSCCs, however, the potential tumour suppressive role of TGFβ signalling in a subset of RDEB cSCCs necessitates biomarker identification to enable patient stratification before clinical intervention. PMID: 32726455 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 28, 2020 Category: Dermatology Authors: Dayal JHS, Mason SM, Salas-Alanis JC, McGrath JA, Taylor RG, Mellerio JE, Blyth K, South AP, Inman GJ Tags: Br J Dermatol Source Type: research

The need for dose-response studies; time for a reminder?
Abstract At the end of a long life, there are too many old haunts to revisit, but by chance I encountered the paper by Heetfeld and colleagues,1 which challenged the idea that skin of people with atopic eczema is supersensitive to irritants. That was surprising, and therefore interesting; so I read it. But, to my further surprise, the study showed no such thing: the authors had come to the wrong conclusion, by reliance on methods and concepts that I thought had been seen off long ago. PMID: 32726866 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 28, 2020 Category: Dermatology Authors: Shuster S Tags: Br J Dermatol Source Type: research

What is a successful repigmentation in vitiligo from patients' view?
Abstract In vitiligo, repigmentation has been defined as a core outcome based on an international e-Delphi consensus.1 Many measurement instruments have been used to assess repigmentation2 , although to date the Vitiligo Extent Score and the Vitiligo Area Severity Index are the best validated.3,4. PMID: 32726875 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 28, 2020 Category: Dermatology Authors: Narayan VS, Uitentuis SE, Bekkenk MW, Wolkerstorfer A Tags: Br J Dermatol Source Type: research

GNAQ/11 mutant nonuveal melanoma: same same but different.
PMID: 32725658 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 27, 2020 Category: Dermatology Authors: Rafei-Shamsabadi D Tags: Br J Dermatol Source Type: research

Pre-emptive intra-auricular electrosurgical resurfacing of cylindromas to prevent conductive deafness in CYLD cutaneous syndrome.
PMID: 32716048 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 26, 2020 Category: Dermatology Authors: Langtry J, Rajan N Tags: Br J Dermatol Source Type: research

Eribulin for recurrent cutaneous angiosarcoma.
PMID: 32716049 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 26, 2020 Category: Dermatology Authors: Smrke A, Benson C Tags: Br J Dermatol Source Type: research

Multiple lentigines and cutaneous hyperpigmentation caused by a KIT mutation.
PMID: 32716058 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 26, 2020 Category: Dermatology Authors: Jiang X, Lin Z, Wang H Tags: Br J Dermatol Source Type: research

The modulating effect of dermal-epidermal crosstalk on the repair efficiency of cyclobutane pyrimidine dimers in keratinocytes.
PMID: 32716069 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 26, 2020 Category: Dermatology Authors: Cadet J Tags: Br J Dermatol Source Type: research

Characterizing Physical Symptoms of Flare in Hidradenitis Suppurativa: A Patient Survey.
Abstract An anonymous survey was posted on HS Facebook groups by group administrators February-March 2020. Participants were asked to self-report Hurley stage (based on text descriptions), select symptoms from a list that they believed characterized HS flare, and then select their most defining flare symptom. Significant findings (p
Source: The British Journal of Dermatology - July 22, 2020 Category: Dermatology Authors: Fernandez JM, Thompson AM, Kirby JS, Hsiao JL, Shi VY Tags: Br J Dermatol Source Type: research

A Very Peculiar Practice: Dermatology in the era of Covid-19.
Abstract "Aren't you one of the dermatology consultants?" - the staff nurse was looking at me with slightly narrowed eyes, and an expression that wavered between curiosity, confusion, amusement… and then settled on fear and blind panic. It was Saturday morning, and I had just stepped on to a 30 bedded acute COVID ward in the hospital for the start of my shift. I was wearing a hopelessly oversized set of theatre scrubs, with a stethoscope draped unconvincingly around my neck. PMID: 32702172 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 22, 2020 Category: Dermatology Authors: Walsh S, Creamer D Tags: Br J Dermatol Source Type: research

High incidence of hand eczema in Danish school children following intensive hand hygiene during the COVID-19 pandemic - a nationwide questionnaire study.
Abstract During the COVID-19 pandemic of Spring 2020, Denmark was one of the first countries to introduce lockdown measures. This included closing of all schools throughout Denmark by 16 March 2020. Primary schools were reopened on 15 April 2020 for grades zero to five. Specific hand hygiene guidelines were issued by the Danish Health Authorities to prevent the transmission of coronavirus: children were instructed to wash their hands for 45-60 seconds with water and soap at least every two hours and specifically upon arrival at school, before and after meals, after toilet visits, after coughing/sneezing, and whene...
Source: The British Journal of Dermatology - July 21, 2020 Category: Dermatology Authors: Simonsen AB, Ruge IF, Quaade AS, Johansen JD, Thyssen JP, Zachariae C Tags: Br J Dermatol Source Type: research

Congenital bilateral scar-like lesions on the face.
PMID: 32696461 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 20, 2020 Category: Dermatology Authors: Durack A, Holden ST, Burrows NP Tags: Br J Dermatol Source Type: research

Ubiquitin, a novel therapeutic target in psoriasis?
PMID: 32696474 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 20, 2020 Category: Dermatology Authors: O'Shaughnessy RFL Tags: Br J Dermatol Source Type: research

A case of cowpox virus infection in the UK occurring in a domestic cat and transmitted to the adult male owner.
PMID: 32696487 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - July 20, 2020 Category: Dermatology Authors: Haddadeen C, Van Ouwerkerk M, Vicek T, Fityan A Tags: Br J Dermatol Source Type: research