Incidence, prevalence, and mortality of bullous pemphigoid in England 1998-2017: a population-based cohort study.
CONCLUSIONS: We report a modest increase in the incidence rate of bullous pemphigoid, but show that the burden of disease in the elderly population is considerable. Mortality is high, particularly in the first two years after diagnosis. PMID: 32147814 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 9, 2020 Category: Dermatology Authors: Persson MSM, Harman KE, Vinogradova Y, Langan SM, Hippisley-Cox J, Thomas KS, Gran S Tags: Br J Dermatol Source Type: research

"Mind the gap": What patients and clinicians believe is "unknown" about psoriasis.
"Mind the gap": What patients and clinicians believe is "unknown" about psoriasis. Br J Dermatol. 2020 Mar 09;: Authors: Majeed-Ariss R, McPhee M, McAteer H, Griffiths CEM, Young HS Abstract A Priority Setting Partnership (PSP) provides an opportunity for clinicians and patients to jointly decide the research priorities for a specific disease area. The James Lind Alliance (JLA), a non-profit making initiative established in 2004 which is funded by the National Institute for Health Research (NIHR), have developed methodology to facilitate PSPs. The JLA believe that medical research ...
Source: The British Journal of Dermatology - March 9, 2020 Category: Dermatology Authors: Majeed-Ariss R, McPhee M, McAteer H, Griffiths CEM, Young HS Tags: Br J Dermatol Source Type: research

Emergency management for preventing and controlling nosocomial infection of 2019 novel coronavirus: implications for the dermatology department.
Abstract As of Feb 15, 2019, the novel coronavirus (2019-nCoV) has rapidly spread throughout China and across the world with more than 60,000 laboratory-confirmed cases. Due to the current lack of specific treatment and the risk of transmission during the viral incubation period, infection prevention and control of 2019-nCoV are both urgent and critical to global health. In this article, we aim to highlight the necessity of implementing protective measures, and recommend how to set proper emergency management plans for preventing and controlling nosocomial infection of 2019-nCoV in dermatology departments. PM...
Source: The British Journal of Dermatology - March 5, 2020 Category: Dermatology Authors: Tao J, Song Z, Yang L, Huang C, Feng A, Man X Tags: Br J Dermatol Source Type: research

Evidence for interactions between filaggrin null mutations and environmental exposures in the aetiology of atopic dermatitis is currently lacking.
PMID: 32141071 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 5, 2020 Category: Dermatology Authors: Park YM, Seo SJ Tags: Br J Dermatol Source Type: research

Yes, accurately measuring and valuing health-related productivity loss is important, but can we afford any longer not to prevent and address it?
PMID: 32141072 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 5, 2020 Category: Dermatology Authors: Drabo EF, Levy JF, Gaskin DJ Tags: Br J Dermatol Source Type: research

The patient experience of pain in hidradenitis suppurativa.
Abstract Nielsen et al.1 recently highlighted the need for additional studies detailing hidradenitis suppurativa (HS) pain before giving specific treatment recommendations. Few studies have evaluated HS-specific pain using patients' own words and this study was designed to address this gap. A descriptive understanding of different elements of the pain experience will aid dermatologists, pain management specialists and health psychologists in the comprehensive, interdisciplinary assessment and treatment of HS. PMID: 32134499 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 5, 2020 Category: Dermatology Authors: Patel ZS, Hoffman LK, Sutton L, Cohen SR, Lowes MA, Seng EK Tags: Br J Dermatol Source Type: research

Ex vivo Confocal Microscopy: revolution in fast pathology in dermatology.
uig S Abstract Confocal Microscopy (CM) with in vivo and ex vivo modalities has been used in the evaluation of skin cancer and other dermatological disorders. Recent developments in ex-vivo CM allows for faster pathology assessment with greater accuracy by the visualisation of cellular and architectural details similar to standard pathology either in paraffin embedded or frozen samples. They include the possibility of multimodal confocal microscopy using different lasers and fusion images. New staining protocols including immunostaining with no damage to conventional histopathology preparation have been recently d...
Source: The British Journal of Dermatology - March 5, 2020 Category: Dermatology Authors: Malvehy J, Pérez-Anker J, Toll A, Pigem R, Garcia A, Alos LL, Puig S Tags: Br J Dermatol Source Type: research

Trends in malignant melanoma mortality in 31 countries from 1985 to 2015.
CONCLUSIONS: Overall increase in MM mortality over the past 30 years was observed. However, there was notable variation in mortality trends between countries, as well as between males and females, and between different age groups. PMID: 32133614 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 4, 2020 Category: Dermatology Authors: Yang DD, Salciccioli JD, Marshall DC, Sheri A, Shalhoub J Tags: Br J Dermatol Source Type: research

Survival in 31 670 patients with thin melanomas - a Swedish population-based study.
CONCLUSION: Long-term MSS was confirmed excellent for patients with thin CMMs in Sweden. Although we could show a decreased MSS for patients with 0·7 mm and above, the long-term survival and in addition a very favourable CMSS for those patients, do not support more extended follow-up programs than current recommendations in Sweden. PMID: 32133615 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 4, 2020 Category: Dermatology Authors: Isaksson K, Mikiver R, Eriksson H, Lapins J, Nielsen K, Ingvar C, Lyth J Tags: Br J Dermatol Source Type: research

Switching from one infliximab biosimilar (CT-P13) to another infliximab biosimilar (SB2) in patients with chronic plaque psoriasis.
Abstract CT-P13 and SB2 are two distinct biosimilars of the reference originator anti-tumour necrosis factor alpha monoclonal antibody infliximab. Real-life evidence has shown that the switch from infliximab originator to CT-P13 did not impair overall clinical efficacy and safety in patients with Crohn's disease, ulcerative colitis, spondyloarthritis, rheumatoid arthritis, psoriatic arthritis and chronic plaque psoriasis. PMID: 32133618 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 4, 2020 Category: Dermatology Authors: Gisondi P, Virga C, Piaserico S, Meneguzzo A, Odorici G, Conti A, Girolomoni G Tags: Br J Dermatol Source Type: research

Low-dose naltrexone in Hailey-Hailey disease: the importance of dosing.
Abstract We read with great interest the study by Jasans-Barceló et al. where they report the response of low-dose naltrexone in 8 patients of HHD.1 One interesting observation we made in the article was the response of one patient to the standard higher dose (50 mg) of naltrexone. Two previous studies that used the 50 mg dose in HHD patients (3 patients total) had failed to show any positive response. PMID: 32133619 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 4, 2020 Category: Dermatology Authors: Acharya P, Mathur M Tags: Br J Dermatol Source Type: research

Statins may reduce disease recurrence in patients with ulcerated primary melanoma.
CONCLUSION: Statins commenced before melanoma diagnosis, may reduce the risk of melanoma recurrence, especially in males and those with ulcerated tumours. Clinical trial evaluation of the potential role of statins in improving the prognosis of high-risk melanoma is warranted. PMID: 32133622 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 4, 2020 Category: Dermatology Authors: von Schuckmann LA, Khosrotehrani K, Ghiasvand R, Hughes MCB, van der Pols JC, Malt M, Smithers BM, Green AC Tags: Br J Dermatol Source Type: research

The association between partner bereavement and melanoma: cohort studies in the U.K. and Denmark.
CONCLUSIONS: We found decreased risk of melanoma diagnosis, but increased mortality associated with partner bereavement. These findings may be partly explained by delayed detection resulting from the loss of a partner who could notice skin changes. Stress may play a role in melanoma progression. Our findings indicate the need for a low threshold for skin examination in individuals whose partners have died. PMID: 32128788 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 3, 2020 Category: Dermatology Authors: Wong AYS, Frøslev T, Dearing L, Forbes HJ, Mulick A, Mansfield KE, Silverwood RJ, Kjaersgaard A, Sørensen HT, Smeeth L, Lewin A, Schmidt SAJ, Langan SM Tags: Br J Dermatol Source Type: research

Drug Survival of Adalimumab, Ustekinumab, and Secukinumab in Patients with Psoriasis: a Prospective Cohort Study from the British Association of Dermatologists Biologics and Immunomodulators Register (BADBIR).
CONCLUSIONS: Secukinumab and ustekinumab have similar sustained drug survival, whilst adalimumab has a lower drug survival in patients with psoriasis. Psoriatic arthritis and previous biologic experience were predictors with differential effects between the biologic therapies. PMID: 32124442 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 2, 2020 Category: Dermatology Authors: Yiu ZZN, Mason KJ, Hampton PJ, Reynolds NJ, Smith CH, Lunt M, Griffiths CEM, Warren RB, BADBIR Study Group Tags: Br J Dermatol Source Type: research

The effectiveness of dupilumab in alopecia areata patients with atopic dermatitis: a case series of seven patients.
Abstract Alopecia areata (AA) is one of the most common autoimmune diseases; however, the pathogenesis of the condition has yet to be fully elucidated. A recent study reported a case of severe AA associated with atopic dermatitis (AD) which was successfully treated with dupilumab, a monoclonal antibody against the α subunit of IL-4/IL-13 receptor. PMID: 32118289 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 2, 2020 Category: Dermatology Authors: Harada K, Irisawa R, Ito T, Uchiyama M, Tsuboi R Tags: Br J Dermatol Source Type: research

Evidence for a "window of opportunity" in hidradenitis suppurativa treated with adalimumab: a retrospective, real-life multicenter cohort study.
Evidence for a "window of opportunity" in hidradenitis suppurativa treated with adalimumab: a retrospective, real-life multicenter cohort study. Br J Dermatol. 2020 Mar 02;: Authors: Marzano AV, Genovese G, Casazza G, Moltrasio C, Dapavo P, Micali G, Sirna R, Gisondi P, Patrizi A, Dini V, Bianchini D, Bianchi L, Fania L, Prignano F, Offidani A, Atzori L, Bettoli V, Cannavò SP, Venturini M, Bongiorno MR, Costanzo A, Fabbrocini G, Peris K Abstract BACKGROUND: The anti-tumour necrosis factor (TNF)-α adalimumab is the only licenced biologic for moderate-to-severe hidradenitis suppur...
Source: The British Journal of Dermatology - March 2, 2020 Category: Dermatology Authors: Marzano AV, Genovese G, Casazza G, Moltrasio C, Dapavo P, Micali G, Sirna R, Gisondi P, Patrizi A, Dini V, Bianchini D, Bianchi L, Fania L, Prignano F, Offidani A, Atzori L, Bettoli V, Cannavò SP, Venturini M, Bongiorno MR, Costanzo A, Fabbrocini G, Peri Tags: Br J Dermatol Source Type: research

Determining the minimal important change scores of the Vitiligo Impact Scale (VIS)-22 and Dermatology Life Quality Index (DLQI) scores in Indian patients with vitiligo using anchor- and distribution-based approaches.
Abstract Dermatology-specific quality-of-life instruments such Dermatology Life Quality Index (DLQI), as well as vitiligo-specific instruments are available to study the quality of life of patients with vitiligo. Vitiligo Impact Scale (VIS)-22 is a validated vitiligo-specific instrument, and clinical meaning has been assigned to its absolute scores.1,2 The minimal important change (MIC) is the smallest difference in a score that is considered significant by the patient and/or physician. We conducted this study to determine the MIC scores of VIS-22 as well as DLQI scores in vitiligo. PMID: 32119113 [PubMed - a...
Source: The British Journal of Dermatology - March 2, 2020 Category: Dermatology Authors: Gupta V, Taneja N, Sati HC, Sreenivas V, Ramam M Tags: Br J Dermatol Source Type: research

Feasibility of a trial to evaluate nicotinamide for chemoprevention of skin cancers in organ transplant recipients in the UK.
Abstract Keratinocyte cancers (KC) are the commonest malignancies in the UK population, with rates increasing annually. Nicotinamide (vitamin B3) has recently been reported to reduce the incidence of KC in high-risk patients. It is a precursor of nicotinamide adenine dinucleotide (NAD+) which replenishes cellular energy levels and enhances efficient repair of ultraviolet light (UV) induced DNA damage within keratinocytes. PMID: 32119116 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 2, 2020 Category: Dermatology Authors: Gollins C, Shah A, Sinha K, Khan S, Paul N, Meeajun B, Abbott RA, Blasdale C, Cooper H, Harwood CA, Ismail F, Lear JT, Mackintosh L, McCormack S, Perrett CM, Proby CM, Durack A, Patalay R, Matin RN Tags: Br J Dermatol Source Type: research

Creating new guidelines on how best to treat foot symptoms in people with EB.
Abstract Epidermolysis bullosa (EB) is a complex rare condition that affects the skin and many parts of the body. Those born with EB have skin so fragile they are called 'butterfly children', their skin is quite simply as fragile as the wing of a butterfly. In the UK it is estimated that there are more than 5,000 people living with EB and 500,000 worldwide. Little clinical guidance for care existed until DEBRA International started a programme to develop clinical practice guidelines (CPGs). There were no previous guidelines and few published studies on foot care in EB so treatment decisions were largely based on i...
Source: The British Journal of Dermatology - March 1, 2020 Category: Dermatology Authors: Khan MT, O'Sullivan M, Faitli B, Mellerio JE, Fawkes R, Wood M, Hubbard LD, Harris AG, Iacobaccio L, Vlahovic T, James L, Brains L, Fitzpatrick M, Mayre-Chilton K Tags: Br J Dermatol Source Type: research

The need for strategies to address obesity and psoriatic arthritis prevention in psoriasis.
PMID: 32107778 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 1, 2020 Category: Dermatology Authors: Ogdie A, Eder L Tags: Br J Dermatol Source Type: research

Editor's Choice: rare skin diseases themed issue.
PMID: 32107779 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 1, 2020 Category: Dermatology Authors: Ingram J Tags: Br J Dermatol Source Type: research

Pachyonychia congenita, a paradigm for rare skin disorders.
PMID: 32107781 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - March 1, 2020 Category: Dermatology Authors: Steele L, O'Toole EA Tags: Br J Dermatol Source Type: research

Efficiency in patch testing: the number needed to test to get one relevant result as a new approach in the evaluation of baseline series.
acute;lez I, Giménez Arnau A Abstract Patch testing is a common procedure, where the baseline series is frequently used as a first screening. The number and the specific allergens of these series varies from country to country and keep changing over the years. Although the European Society of Contact Dermatitis (ESCD) made recommendations about patch testing1 , the decisions about the European baseline series were traditionally delegated to the European Environmental Contact Dermatitis Research Group (EECDRG)2 . A different, more reactive, approach has been recently proposed by the ESCD task force3 , using ...
Source: The British Journal of Dermatology - February 28, 2020 Category: Dermatology Authors: Gavín J, Mercader P, Descalzo MA, Garcia-Doval I, Silvestre JF, Sánchez-Pérez J, Fernández-Redondo V, Armario-Hita JC, Ruiz-González I, Giménez Arnau A Tags: Br J Dermatol Source Type: research

Measurement properties of the PROMIS Itch Questionnaire - itch severity assessments in adults with atopic dermatitis.
Abstract BACKGROUND: Little is known about the validity of numeric and verbal rating scales (NRS and VRS) for itch and itch frequency for assessing itch severity in AD. We evaluated the Patient-Reported Outcomes Information System (PROMIS® ) Itch Questionnaire (PIQ) - itch severity assessment, including multiple NRS, VRS and frequency of itch assessments, in adults with AD and compared their performance. METHODS: Self-administered questionnaires and skin-examination were performed in 410 AD patients (age 18-90 years) in a dermatology practice setting. RESULTS: PIQ NRS, VRS and frequency of itch had g...
Source: The British Journal of Dermatology - February 27, 2020 Category: Dermatology Authors: Silverberg JI, Lai JS, Patel K, Singam V, Vakharia PP, Chopra R, Sacotte R, Kantor R, Hsu DY, Cella D Tags: Br J Dermatol Source Type: research

What are the barriers to physical activity in patients with chronic plaque psoriasis?
CONCLUSION: Psoriasis-specific factors - severity, skin sensitivity, clothing choice, participation in social / leisure activities and treatments - contribute to exercise avoidance and may augment the increased risk of CVD in patients with psoriasis. PMID: 32107775 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 27, 2020 Category: Dermatology Authors: Auker L, Cordingley L, Pye DR, Griffiths CEM, Young HS Tags: Br J Dermatol Source Type: research

Trends and current spectrum of contact allergy in Central Europe: Results of the Information Network of Departments of Dermatology (IVDK), 2007 - 2018.
CONCLUSIONS: Decreases in sensitisation prevalence likely reflect reduced exposure, with some lag, as for hydroxyisohexyl 3-cyclohexene carboxaldehyde. If no (sufficient) decrease can be observed despite interventions, such as for nickel and chromium, affected subgroups should be identified and their causative exposures explored. Finally, increases like observed with propolis certainly warrant targeted investigation of exposures driving sensitisation, and possibly intervention. PMID: 32107776 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 27, 2020 Category: Dermatology Authors: Uter W, Gefeller O, Mahler V, Geier J Tags: Br J Dermatol Source Type: research

Skin cancer burden in lung transplant recipients: we need to do better!
PMID: 32100285 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 25, 2020 Category: Dermatology Authors: Proby CM, Harwood CA Tags: Br J Dermatol Source Type: research

Self-management: PROMs can prompt support.
PMID: 32090316 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 23, 2020 Category: Dermatology Authors: Pattinson R, Bundy C Tags: Br J Dermatol Source Type: research

Mercury exposure and nonmelanoma skin cancer: what're the odds?
PMID: 32090319 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 23, 2020 Category: Dermatology Authors: Taylor N Tags: Br J Dermatol Source Type: research

Dermoscopy and reflectance confocal microscopy for early diagnosis of amelanotic/hypomelanotic melanoma: still a long way to go?
PMID: 32090328 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 23, 2020 Category: Dermatology Authors: Chi CC Tags: Br J Dermatol Source Type: research

Artificial intelligence in dermatology: the 'unsupervised' learning.
Abstract The potential areas of application of artificial intelligence in dermatology are ever increasing. With the wide availability of smartphones equipped with high-resolution cameras and impressive processing powers, harnessing these capabilities using machine learning (ML) could open new prospects in the management of dermatological disorders. Du-Harpur et al. have done a commendable job reviewing the utility of artificial intelligence in dermatology in an easily understandable manner for most dermatologists. PMID: 32086797 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 21, 2020 Category: Dermatology Authors: Acharya P, Mathur M Tags: Br J Dermatol Source Type: research

The interaction between filaggrin mutations and hard domestic water on the risk of early-onset atopic dermatitis.
Abstract We read with interest the article by Jabbar-Lopez et al.,1 showing a significant interaction between filaggrin gene (FLG) loss-of-function mutations and exposure to domestic water hardness (≤256 mg/L versus>256 mg/L calcium carbonate (CaCO3 ) on the risk of atopic dermatitis (AD) at 36 months of age. PMID: 32083316 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 21, 2020 Category: Dermatology Authors: Halling AS, Bager P, Skov L, Zachariae C, Wohlfahrt J, Melbye M, Thyssen JP Tags: Br J Dermatol Source Type: research

Topical imiquimod monotherapy for indolent primary cutaneous B-cell lymphomas (PCBCL): a single-institution experience.
Abstract Primary cutaneous B-cell lymphomas (PCBCL) are rare extranodal lymphoproliferative disorders that present in the skin and seldom disseminate systemically. The World Health Organization - European Organization for Research and Treatment of Cancer (WHO-EORTC) define three PCBCL types: primary cutaneous marginal zone lymphoma (PCMZL) and primary cutaneous follicle-center lymphoma (PCFCL) are histologically low grade and clinically indolent; primary cutaneous diffuse large B-cell lymphoma, leg type (PCDLBCL-LT) is clinically and histologically aggressive. Staging is based on number, size, and areas of distrib...
Source: The British Journal of Dermatology - February 20, 2020 Category: Dermatology Authors: Hwang S, Johnson A, Fabbro S, Hastings J, Haverkos B, Chung C, Porcu P, William B Tags: Br J Dermatol Source Type: research

Indoor tanning use is associated with psoriasis from the Nurses' Health Study II.
Abstract Psoriasis is a chronic immune-mediated disease of the skin that affects approximately 2% of the US and Europe population1 . The disease presents a significant burden for affected individuals and negatively affects their quality of life. Environmental and life-style factors play important roles in this disease, and several complex disorders have also been linked to psoriasis1,2 . Phototherapy, performed under medical supervision, is an effective treatment for psoriasis1 . Indoor tanning produces artificial ultraviolet radiation and has been shown to increase the risk of skin cancer and accelerate skin agin...
Source: The British Journal of Dermatology - February 20, 2020 Category: Dermatology Authors: Choong CK, Merola JF, Han J, Li X Tags: Br J Dermatol Source Type: research

American Cutaneous Leishmaniasis in French Guiana: a retrospective comparison between liposomal amphotericin B and meglumine antimoniate.
zot R Abstract New World cutaneous leishmaniasis (CL) is endemic in many countries of Latin America, including French Guiana 1 . While pentamidine is the first-line treatment against Leishmania guyanensis in this territory 2 , pentavalent antimonials such as meglumine antimoniate (MA) are recommended in case of L. braziliensis or pentamidine-resistant strains of other species 2 . Liposomal amphotericin B (L-AmB) (Ambisome ®) is widely used against fungi and visceral leishmaniasis 3 . However, data concerning its efficacy in New World CL are scarce and contradictory 4-7 . Due to a shortage in MA, the Cayenne Ho...
Source: The British Journal of Dermatology - February 20, 2020 Category: Dermatology Authors: Senchyna A, Simon S, Cissé H, Ginouves M, Prevot G, Alcoba G, Demar M, Couppie P, Blaizot R Tags: Br J Dermatol Source Type: research

Cross-sectional study identifies lower risk of Staphylococcus aureus nasal colonisation in Danish blood donors with Hidradenitis suppurativa symptoms.
Abstract Hidradenitis suppurativa (HS) is a chronic skin disease with point prevalence between 1% and 4%, characterized by recurrent inflammation and painful formation of nodules in the intertriginous areas of the skin. In some patients, these lesions progress into the formation of abscesses and/or tunnels, ultimately causing restrictive scaring, and health-related quality of life impairment. Growing evidence suggests that the primary event is infundibular hyperkeratosis at the terminal follicles causing follicle dilatation and perifollicular inflammation followed by cyst formation.1 However, the exact aetiology o...
Source: The British Journal of Dermatology - February 20, 2020 Category: Dermatology Authors: Dinh KM, Erikstrup LT, Andersen RK, Andersen PS, Mikkelsen S, Kjerulff BD, Burgdorf KS, Hansen TF, Nielsen KR, Hjalgrim H, Jemec GB, Ullum H, Erikstrup C, Pedersen OB Tags: Br J Dermatol Source Type: research

Ongoing cancer burden after a diagnosis of cutaneous squamous cell carcinoma.
PMID: 32077097 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 19, 2020 Category: Dermatology Authors: Youlden DR, Baade PD Tags: Br J Dermatol Source Type: research

Assessing the Effect of Clinical Trial Evidence and Anecdote on Caregivers' Willingness to Use Corticosteroids: A Randomized Controlled Trial. A Critical Appraisal.
Abstract AIM: Johnson et al. [1] aimed to assess caregivers' willingness to treat childhood atopic dermatitis (AD) with a corticosteroid when presented with clinical trial evidence, anecdote, or both. SETTING AND DESIGN: This prospective parallel group (1:1; 8 groups) randomised control trial was carried out with caregivers recruited from a tertiary care dermatology clinic in the United States of America (USA) and an online crowdsourcing platform using caregivers who may not have had a child with AD. STUDY EXPOSURE: Caregivers were randomised to 8 groups. The 3 main groups were given clinical trial evide...
Source: The British Journal of Dermatology - February 18, 2020 Category: Dermatology Authors: Brown A, Tsianou Z, Williams H Tags: Br J Dermatol Source Type: research

Results from the BJD survey on readership views towards clinical practice guidelines.
The objective of this study was to survey the BJD readership's demographics, utility of and attitudes towards CPGs. PMID: 32072620 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 18, 2020 Category: Dermatology Authors: Yiu ZZN, Jabbar-Lopez ZK, Ahmed S, Mohd Mustapa MF, Chi CC, Flohr C Tags: Br J Dermatol Source Type: research

Implementation of dupilumab in routine care of atopic eczema. Results from the German national registry TREATgermany.
warz B, Bell M, Neubert K, Effendy I, Bieber T, Homey B, Gerlach B, Tchitcherina E, Stahl M, Schwichtenberg U, Rossbacher J, Buck P, Mempel M, Beissert S, Werfel T, Weidinger S, Schmitt J, TREATgermany study group Abstract The German atopic eczema (AE)-registry TREATgermany is a non-interventional multicenter patient cohort study for adult patients with currently moderate-to-severe disease activity or current/previous anti-inflammatory systemic treatment.1,2 Dupilumab has demonstrated to be an effective treatment for patients with moderate-to-severe AE in clinical trials.3-5 Real world evidence is now needed to ev...
Source: The British Journal of Dermatology - February 18, 2020 Category: Dermatology Authors: Abraham S, Haufe E, Harder I, Heratizadeh A, Kleinheinz A, Wollenberg A, Weisshaar E, Augustin M, Wiemers F, Zink A, Biedermann T, von Kiedrowski R, Hilgers M, Worm M, Pawlak M, Sticherling M, Fell I, Handrick C, Schäkel K, Staubach P, Asmussen A, Schwar Tags: Br J Dermatol Source Type: research

Where do we stand with immune checkpoint blockade for advanced cutaneous squamous cell carcinoma? A systematic review and critical appraisal of existing evidence.
t MV Abstract Immune checkpoint blockade (ICB) has tremendously changed the field of oncological therapy. Recently, the PD-1-blocking antibody cemiplimab was approved by the FDA and the EMA for the treatment of advanced cutaneous squamous cell carcinoma (cSCC).1 However, clinical practice guidelines currently do not cover specific recommendations regarding the management of advanced cSCC with ICB. Hence, we have performed a systematic review on the current use of ICB for advanced cSCC. PMID: 32068244 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 18, 2020 Category: Dermatology Authors: Steeb T, Wessely A, Heppt F, Harlaß M, Berking C, Heppt MV Tags: Br J Dermatol Source Type: research

The European TREatment of ATopic eczema Taskforce (TREAT) Survey; prescribing practices in Europe for phototherapy and systemic therapy in moderate-to-severe adult atopic eczema patients.
CONCLUSIONS: This study provides insight into prescribing practices for conventional photo- and systemic therapies in Europe and shows that off-label therapies are also preferred as first line choice of systemic therapy. PMID: 32068893 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 18, 2020 Category: Dermatology Authors: Vermeulen FM, Gerbens LAA, Schmitt J, Deleuran M, Irvine AD, Logan K, Ouwerkerk W, Vestergaard C, Flohr C, Spuls PI, international TREAT Registry Taskforce Tags: Br J Dermatol Source Type: research

Reliability and validity of the Vitiligo Signs of Activity Score (VSAS).
CONCLUSION: The VSAS appears to be a valid and reliable instrument to score visible clinical signs linked to disease activity in a standardised way. PMID: 32064583 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 16, 2020 Category: Dermatology Authors: van Geel N, Passeron T, Wolkerstorfer A, Speeckaert R, Ezzedine K Tags: Br J Dermatol Source Type: research

The efficacy and safety of topical rapamycin/calcitriol for facial angiofibromas in patients with tuberous sclerosis complex: a prospective, double-blind randomized clinical trial.
Abstract BACKGROUND: The efficacy of topical rapamycin is well-documented for tuberous sclerosis complex (TSC)-related facial angiofibromas (FAs). Calcitriol has been shown to lessen skin fibrosis and may be therapeutically beneficial to FAs. OBJECTIVE: To evaluate if topical rapamycin-calcitriol combination an effective and safe treatment for TSC-related FAs. METHODS: Fifty-two TSC patients with FAs were enrolled in this prospective study including three 12-week periods. In period 1, either topical rapamycin (0.1%) or calcitriol (0.0003%) single-agent therapy versus their combination were applied by a d...
Source: The British Journal of Dermatology - February 16, 2020 Category: Dermatology Authors: Chen PL, Hong JB, Shen LJ, Chen YT, Wang SJ, Liao YH Tags: Br J Dermatol Source Type: research

GNAQ and GNA11 mutant non-uveal melanoma, a subtype distinct from both cutaneous and uveal melanoma.
CONCLUSIONS: Our findings suggest that GNAQ/11 mutant non-uveal melanomas are a melanoma subtype distinct both clinically and genetically from cutaneous and uveal melanoma. As they respond poorly to available treatment regimens, novel effective therapeutic approaches for affected patients are urgently needed. PMID: 32064597 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 16, 2020 Category: Dermatology Authors: Livingstone E, Zaremba A, Horn S, Ugurel S, Casalini B, Schlaak M, Hassel JC, Herbst R, Utikal JS, Weide B, Gutzmer R, Meier F, Koelsche C, Hadaschik E, Sucker A, Reis H, Merkelbach-Bruse S, Siewert M, Sahm F, von Deimling A, Cosgarea I, Zimmer L, Schaden Tags: Br J Dermatol Source Type: research

Incidence of different cancer types in dermatomyositis, polymyositis and dermatopolymyositis: results of a registry analysis.
Abstract Studies confirming Dermatomyositis/polymyositis/dermatopolymyositis (DM/PM/DPM) as a paraneoplastic disease have found cancer incidence rates elevated at the time point of diagnosis and remaining elevated over time. Guidelines promote cancer screening in newly diagnosed myositis patients. Data on the incidence of cancer types in DM/PM patients are insufficient to guide targeted screening. PMID: 32060906 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 14, 2020 Category: Dermatology Authors: Zidane M, Dressler C, Nast A, Egeberg A Tags: Br J Dermatol Source Type: research

Extensive scalp ulcer secondary to delusional infestation treated with antipsychotics and scalp reconstruction.
o MMS PMID: 32052414 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 12, 2020 Category: Dermatology Authors: Pincelli MS, Guimarãres ALM, Milcheski DA, Dwan AJ, Nico MMS Tags: Br J Dermatol Source Type: research

Reading through genetic 'stop signs': a therapeutic strategy in genetic skin disease.
PMID: 32037506 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 9, 2020 Category: Dermatology Authors: Kibbi N, Rajan N Tags: Br J Dermatol Source Type: research

IP-10/CXCR3 axis is associated with HHV-6 reactivation and the development of sequelae in drug reaction with eosinophilia and systemic symptoms.
CONCLUSIONS: Higher plasma IP-10 levels are associated with the development of long-term sequelae in DRESS. Higher IP-10/CXCR3 expression in skin and more abundant CLA+ CXCR3+ CD4+ cells and CLA+ CXCR3+ CD8+ cells were observed in DRESS patients with HHV-6 reactivation. The IP-10/CXCR3 axis is associated with HHV-6 reactivation and development of long-term sequelae in DRESS. PMID: 32037509 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - February 9, 2020 Category: Dermatology Authors: Yang CW, Cho YT, Hsieh YC, Hsu SH, Chen KL, Chu CY Tags: Br J Dermatol Source Type: research

Declining levels of serum CXCL10 over time are associated with new onset of psoriatic arthritis in patients with psoriasis: A new biomarker?
Abstract BACKGROUND: We previously found that serum levels of C-X-C motif chemokine 10 (CXCL10) decreased after PsA onset. OBJECTIVE: We measured CXCL10 levels over time in psoriasis patients who developed PsA to determine whether the drop in CXCL10 was specific to these patients and further assess its association with PsA development. METHODS: Prospectively followed psoriasis patients without arthritis (psoriasis cutaneous [PsC]) were assessed yearly by rheumatologists for the presence of PsA. PsC patients who developed PsA (converters) were matched to those that did not develop PsA (non-converters) bas...
Source: The British Journal of Dermatology - February 9, 2020 Category: Dermatology Authors: Abji F, Lee K, Math M, Pollock RA, Machhar R, Cook RJ, Chandran V, Gladman DD Tags: Br J Dermatol Source Type: research