Vitiligo and skin cancer: is it a question of ethnicity?
PMID: 31621061 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 16, 2019 Category: Dermatology Authors: Gran S Tags: Br J Dermatol Source Type: research

New therapeutics for leprosy.
PMID: 31621065 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 16, 2019 Category: Dermatology Authors: Walker SL Tags: Br J Dermatol Source Type: research

Image Gallery: White piedra.
PMID: 31617200 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 15, 2019 Category: Dermatology Authors: Kumetz EA, Rivard SC Tags: Br J Dermatol Source Type: research

Measuring clinician-machine agreement in differential diagnoses for dermatology.
Abstract Artificial intelligence (AI) algorithms have generated significant interest as a tool to assist in clinical workflows, particularly in image-based diagnostics such as melanoma detection.1,2 These algorithms typically answer narrowly-scoped questions, such as "is this lesion malignant?" By contrast, dermatologists frequently tackle less structured diagnostic questions, such as "what is this rash?" In practice, evaluating clinical cases often involves integrating insights from morphology, context, and history to determine a ranked-ordered list of possible diagnoses, i.e. a differential d...
Source: The British Journal of Dermatology - October 14, 2019 Category: Dermatology Authors: Eng C, Liu Y, Bhatnagar R Tags: Br J Dermatol Source Type: research

Pathogen identification by shotgun metagenomics of patients with necrotising soft-tissue infections.
group Abstract BACKGROUND: Necrotising soft-tissue infections (NSTIs) are life-threatening, requiring broad-spectrum antibiotics. Their etiological diagnosis can be limited by poor performance of cultures and administration of antibiotics before surgery. OBJECTIVES: We aimed to: (i) compare 16S-targeted metagenomics (TM) and unbiased semi-quantitative pan-microorganism DNA- and RNA-based shotgun metagenomics (SM) with cultures, (ii) identify patients who best benefit from metagenomics approaches, and (iii) detect the microbial pathogens in surrounding non-necrotic "healthy" tissues by SM metagenomic...
Source: The British Journal of Dermatology - October 14, 2019 Category: Dermatology Authors: Rodriguez C, Jary A, Hua C, Woerther PL, Bosc R, Desroches M, Sitterlé E, Gricourt G, De Prost N, Pawlotsky JM, Chosidow O, Sbidian E, Decousser JW, multidisciplinary necrotising fasciitis study group Tags: Br J Dermatol Source Type: research

Developing risk prediction models for melanoma: balancing better predictive value with ease of clinical implementation.
PMID: 31608432 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 13, 2019 Category: Dermatology Authors: Toland AE Tags: Br J Dermatol Source Type: research

Open Label Pilot Study of 2% Tofacitinib for the Treatment of Refractory Vitiligo.
Abstract Treatment options for vitiligo are limited and many cases remain refractory to first and second line treatments. Interferon-gamma signaling mediated by Janus kinase (JAK) has been implicated in the pathogenesis of vitiligo.1 Systemic administration of tofacitinib, a potent JAK1/3 inhibitor, has been effective in treating vitiligo in case reports,2 however, it is associated with infections, malignancies, cytopenias, gastrointestinal perforations, and hyperlipidemia in some patients with rheumatoid arthritis. PMID: 31605536 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 12, 2019 Category: Dermatology Authors: Mobasher P, Guerra R, Jiayang Li S, Frangos J, Ganesan AK, Huang V Tags: Br J Dermatol Source Type: research

Standardising the classification of skin tears: validity and reliability testing of the International Skin Tear Advisory Panel (ISTAP) Classification System in 44 countries.
CONCLUSIONS: The ISTAP Classification System is supported by evidence for validity and reliability. The ISTAP Classification System should be used for a systematic assessment and reporting of skin tears in clinical practice and research globally. PMID: 31605618 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 12, 2019 Category: Dermatology Authors: Van Tiggelen H, LeBlanc K, Campbell K, Woo K, Baranoski S, Chang YY, Dunk AM, Gloeckner M, Hevia H, Holloway S, Idensohn P, Karadağ A, Koren E, Kottner J, Langemo D, Ousey K, Pokorná A, Romanelli M, Santos VLCG, Smet S, Tariq G, Van den Bussche K, Van H Tags: Br J Dermatol Source Type: research

The presence of sulfites in "natural rubber latex" and "synthetic" rubber gloves: an experimental pilot study.
The presence of sulfites in "natural rubber latex" and "synthetic" rubber gloves: an experimental pilot study. Br J Dermatol. 2019 Oct 12;: Authors: Dendooven E, Darrigade AS, Foubert K, Pieters L, Lambert J, Goossens A, Aerts O Abstract Sulfites are widely used as antioxidants and preservatives (1-3), but are also frequent contact sensitizers. Indeed, more than 1% of subjects routinely patch-tested to sodium metabisulfite (SMB) 1% diluted in petrolatum (pet.), the best marker to detect contact allergy to sulfites (1), are sensitized to them (1, 4). SMB 1% pet., has recently been p...
Source: The British Journal of Dermatology - October 12, 2019 Category: Dermatology Authors: Dendooven E, Darrigade AS, Foubert K, Pieters L, Lambert J, Goossens A, Aerts O Tags: Br J Dermatol Source Type: research

Mosaic Variant in ATP2C1 Presenting as Relapsing Linear Acantholytic Dermatosis: Case Report.
Abstract Relapsing Linear Acantholytic Dermatosis (RLAD) is a rare disease that manifests as recurring episodes of crusted and vesicular lesions distributed in a Blaschkoid pattern with histology resembling Hailey-Hailey or Darier's disease. RLAD is hypothesized to be a mosaic form of a known acantholytic disorder, but this hypothesis has lacked genetic conformation. To determine the genetic abnormalities causing RLAD, we performed exome sequencing of affected tissue and blood in a single subject. Exome sequencing of an punch biopsy revealed a c.238A>T, p.(Lys80*) variant in ATP2C1 found in 26% of the reads fro...
Source: The British Journal of Dermatology - October 12, 2019 Category: Dermatology Authors: Katzman JA, Chavan R, Holliday A, Coman G, Grider D, Kolodney MS Tags: Br J Dermatol Source Type: research

The prevailing dermoscopic vascular pattern in melanoma is influenced by tumor thickness and pigmentation type.
Abstract In non-pigmented skin tumors the diagnosis is mainly based on the evaluation of the vascular morphology and vessels´ distribution dermoscopically [1-4]. However, up to date, no study formally correlated the prevailing vascular morphology with the thickness of melanoma according to Breslow and amount of pigmentation. PMID: 31605621 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 12, 2019 Category: Dermatology Authors: Deinlein T, Longo C, Schulter G, Pizzichetta MA, Zalaudek I Tags: Br J Dermatol Source Type: research

Longitudinal analysis of the effect of water hardness on atopic eczema: evidence for gene-environment interaction.
CONCLUSIONS: There is evidence of an interaction between water hardness and FLG gene mutations in the development of infantile AE. PMID: 31599965 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 10, 2019 Category: Dermatology Authors: Jabbar-Lopez ZK, Craven J, Logan K, Greenblatt D, Marrs T, Radulovic S, McLean WHI, Lack G, Strachan DP, Perkin MR, Peacock JL, Flohr C Tags: Br J Dermatol Source Type: research

Image Gallery: Widespread erosive tinea corporis mimicking autoimmune bullous dermatoses in a patient with lung cancer.
PMID: 31598958 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 9, 2019 Category: Dermatology Authors: Shen WC, Chang Liao NF, Wu PY Tags: Br J Dermatol Source Type: research

Image Gallery: Antihelix red-violaceous macules in juvenile dermatomyositis associated with antimelanoma differentiation-associated protein 5 antibody.
PMID: 31598963 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 9, 2019 Category: Dermatology Authors: Nagai H, Nishigori C Tags: Br J Dermatol Source Type: research

Image Gallery: Shingle-induced Koebner phenomenon.
PMID: 31598966 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 9, 2019 Category: Dermatology Authors: Gao J, Wang R Tags: Br J Dermatol Source Type: research

No Evidence that Impaired Notch Signaling Differentiates Hidradenitis Suppurativa From Other Inflammatory Skin Diseases.
Abstract The molecular pathogenesis of Hidradenitis Suppurativa (HS) is purported to involve Notch dysregulation secondary to sequence variants in components of the gamma secretase complex (GSC)1 . However, Notch dysregulation has also been identified in keratinocytes of other inflammatory dermatoses including psoriasis2 and atopic dermatitis2 . Animal knockout models of components of the GSC with resultant Notch dysregulation result in the development of dermal cysts and histological features of follicular occlusion, suggesting that aberrant Notch signaling is linked to the unique clinical and histological manife...
Source: The British Journal of Dermatology - October 8, 2019 Category: Dermatology Authors: Frew JW, Navrazhina K Tags: Br J Dermatol Source Type: research

Dupilumab in adolescents with uncontrolled moderate-to-severe atopic dermatitis: results from a phase IIa open-label trial and subsequent phase III open-label extension.
CONCLUSIONS: In adolescents with moderate-to-severe AD, dupilumab's pharmacokinetic profile was similar to that in adults. These 52-week safety and efficacy data support long-term use of dupilumab in this patient population. What's already known about this topic? Adolescents with moderate-to-severe atopic dermatitis (AD) have high unmet medical need, with significant disease burden and limited treatment options. Dupilumab (monoclonal antibody against interleukin-4 receptor α) is approved for the treatment of adolescents with moderate-to-severe AD who are inadequately responsive to standard of care (U.S.A.) or candida...
Source: The British Journal of Dermatology - October 8, 2019 Category: Dermatology Authors: Cork MJ, Thaçi D, Eichenfield LF, Arkwright PD, Hultsch T, Davis JD, Zhang Y, Zhu X, Chen Z, Li M, Ardeleanu M, Teper A, Akinlade B, Gadkari A, Eckert L, Kamal MA, Ruddy M, Graham NMH, Pirozzi G, Stahl N, DiCioccio AT, Bansal A Tags: Br J Dermatol Source Type: research

The psychological functioning of children with Epidermolysis Bullosa (EB) and its relationship with specific aspects of disease.
Abstract Epidermolysis Bullosa (EB) is a group of genetic conditions resulting in skin and mucosal membrane fragility. EB is characterised by chronic wounds and scarring, consequent functional limitations and high levels of pain. In its most severe forms, life expectancy is significantly foreshortened. PMID: 31587254 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 6, 2019 Category: Dermatology Authors: Soon K, Mason R, Martinez AE, Mellerio JE Tags: Br J Dermatol Source Type: research

Aplasia cutis congenita associated with a heterozygous loss-of-function UBA2 variant.
Abstract Aplasia cutis congenita (ACC) is an isolated or syndromic congenital skin defect with the absence of skin and occasionally subcutaneous tissue, commonly seen as localised lesions on the scalp vertex. Syndromic ACC is associated with limb, neurological, cardiovascular, gastrointestinal, genitourinary, placental, and dermatological anomalies.1 Familial reports of ACC suggest a Mendelian inheritance although the underlying genetics has not been completely clarified.2 Here we report a family with mother and son both affected by ACC and found to have a heterozygous variant in UBA2. PMID: 31587267 [PubMed ...
Source: The British Journal of Dermatology - October 6, 2019 Category: Dermatology Authors: Wang Y, Dupuis L, Jobling R, Kannu P Tags: Br J Dermatol Source Type: research

Consensus definitions of disease activity in hidradenitis suppurativa: crossing the semantic gap.
PMID: 31583685 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 3, 2019 Category: Dermatology Authors: Navrazhina K, Frew JW Tags: Br J Dermatol Source Type: research

The pharmacology of itch.
PMID: 31578709 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 3, 2019 Category: Dermatology Authors: Ingram JR, Ahluwalia A Tags: Br J Dermatol Source Type: research

Common methodological pitfalls and new developments in systematic review meta-analyses.
PMID: 31576568 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 1, 2019 Category: Dermatology Authors: Leonardi-Bee J, Flohr C, van Zuuren EJ, Le Cleach L, Hollestein LM Tags: Br J Dermatol Source Type: research

Nonsteroidal anti-inflammatory drug associations with nonmelanoma skin cancer - the saga continues.
PMID: 31576570 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 1, 2019 Category: Dermatology Authors: Rundle CW, Dellavalle RP Tags: Br J Dermatol Source Type: research

Acne in the 21st century.
PMID: 31576571 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 1, 2019 Category: Dermatology Authors: van Steensel MAM Tags: Br J Dermatol Source Type: research

Are demodex mites the best target for rosacea treatments?
PMID: 31576573 [PubMed - in process] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - October 1, 2019 Category: Dermatology Authors: Thyssen JP Tags: Br J Dermatol Source Type: research

Validation of an Oral Disease Severity Score (ODSS) tool for use in oral mucous membrane pemphigoid.
Abstract BACKGROUND: Mucous membrane pemphigoid (MMP) is a rare autoimmune bullous disease predominantly affecting the oral mucosa. Optimal management relies upon thorough clinical assessment and documentation at each visit. OBJECTIVES: The primary aim of this study was to validate the Oral Disease Severity Score (ODSS) for the assessment of oral involvement in MMP. We also compared its inter- and intra-observer reliability with the oral parts of the Mucous Membrane Pemphigoid Disease Area Index (MMPDAI), Autoimmune Bullous Skin Disorder Intensity Score (ABSIS) and Physician's Global Assessment (PGA). ME...
Source: The British Journal of Dermatology - September 30, 2019 Category: Dermatology Authors: Ormond M, McParland H, Thakrar P, Donaldson ANA, Andiappan M, Cook RJ, Escudier ME, Higham J, Hullah E, McMillan R, Taylor J, Shirlaw PJ, Challacombe SJ, Setterfield JF Tags: Br J Dermatol Source Type: research

Old mitochondria accumulate in pachyonychia congenita.
PMID: 31571193 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 30, 2019 Category: Dermatology Authors: Vetter A, Magin TM Tags: Br J Dermatol Source Type: research

Image Gallery: Giant rhinophyma.
PMID: 31571194 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 30, 2019 Category: Dermatology Authors: Qian YT, Ma JY, Vano-Galvan S, Ma DL Tags: Br J Dermatol Source Type: research

Can the dose and dosing interval of biologics be optimized?
PMID: 31571195 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 30, 2019 Category: Dermatology Authors: Morita A, Ikumi K Tags: Br J Dermatol Source Type: research

Psoriasis, gut and microbiome.
PMID: 31571198 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 30, 2019 Category: Dermatology Authors: Alexeyev O Tags: Br J Dermatol Source Type: research

Overcoming poor adherence is a major hurdle to managing atopic dermatitis.
PMID: 31571203 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 30, 2019 Category: Dermatology Authors: Strowd LC, Feldman SR Tags: Br J Dermatol Source Type: research

Clinicopathological factors associated with death from thin ( ≤1.00mm) melanoma.
Clinicopathological factors associated with death from thin (≤1.00mm) melanoma. Br J Dermatol. 2019 Sep 28;: Authors: Claeson M, Baade P, Brown S, Soyer HP, Smithers BM, Green AC, Whiteman DC, Khosrotehrani K Abstract BACKGROUND: Thin cutaneous melanomas (≤1.00mm) are increasing worldwide, causing around a quarter of all melanoma deaths in the USA and Australia. Identification of predictive factors for potentially fatal thin melanomas could allow better use of resources for follow-up. OBJECTIVES: To identify clinicopathological factors associated with fatal thin melanomas. METHODS: Thi...
Source: The British Journal of Dermatology - September 28, 2019 Category: Dermatology Authors: Claeson M, Baade P, Brown S, Soyer HP, Smithers BM, Green AC, Whiteman DC, Khosrotehrani K Tags: Br J Dermatol Source Type: research

Challenging a paradigm: Skin sensitivity to sodium lauryl sulfate is independent of atopic diathesis.
CONCLUSIONS: We found no association of increased skin irritability to SLS with atopic skin diathesis, atopic dermatitis, allergic rhinitis, or allergic asthma in a large patient cohort. It therefore seems that the test of skin irritability with SLS, which is common practice in many centers so far, does not allow to predict the susceptibility to irritant eczematous inflammation in atopic vs. non-atopic individuals. PMID: 31562780 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 28, 2019 Category: Dermatology Authors: Heetfeld AB, Schill T, Schröder SS, Forkel S, Mahler V, Pfützner W, Schön MP, Geier J, Buhl T Tags: Br J Dermatol Source Type: research

Could psoralen plus ultraviolet A1 ("PUVA1") work? Depth penetration achieved by phototherapy lamps.
Could psoralen plus ultraviolet A1 ("PUVA1") work? Depth penetration achieved by phototherapy lamps. Br J Dermatol. 2019 Sep 28;: Authors: Barnard IRM, Eadie E, McMillan L, Moseley H, Brown T, Wood K, Dawe R Abstract Psoralen and ultraviolet A (PUVA) is useful in treating various hand and foot skin diseases.1 Most cases of psoriasis respond well to phototherapy or PUVA. However, for some diseases, such as palmoplantar pustular psoriasis, PUVA is not always sufficient to produce therapeutic effect. If PUVA fails, it is sometimes necessary to progress to other treatments such as Grenz ray ther...
Source: The British Journal of Dermatology - September 28, 2019 Category: Dermatology Authors: Barnard IRM, Eadie E, McMillan L, Moseley H, Brown T, Wood K, Dawe R Tags: Br J Dermatol Source Type: research

Isotretinoin is indirectly effective in sebocytes.
ulis CC, Törőcsik D Abstract In a recently published research letter Burney et al. demonstrated that isotretinoin (13-cis-retinoic acid, 13CRA) induced acnegenic changes in SEB-1 cultured human sebocytes1 . However, Melnik et al., suggested that the observed changes may largely be influenced by the Simian virus (SV)-40 immortalization of the used cell line, which may inhibit the p53 pathway and together with 13CRA lead to changes, such as the down-regulation of the forkhead box O (FoxO) pathway. In contrast, they found that the FoxO pathway was upregulated in samples from patients receiving 13CRA treatment f...
Source: The British Journal of Dermatology - September 28, 2019 Category: Dermatology Authors: Kovács D, Hegyi K, Szegedi A, Deák D, Póliska S, Rühl R, Zouboulis CC, Törőcsik D Tags: Br J Dermatol Source Type: research

Efficacy and safety of dupilumab in Japanese adults with moderate-to-severe atopic dermatitis: a subanalysis of three clinical trials.
CONCLUSIONS: Dupilumab alone or with TCS improved signs and symptoms of AD, had an acceptable safety profile, and suppressed biomarkers of type 2 inflammation compared to placebo in Japanese adult patients with moderate-to-severe AD. PMID: 31564057 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 28, 2019 Category: Dermatology Authors: Katoh N, Kataoka Y, Saeki H, Hide M, Kabashima K, Etoh T, Igarashi A, Imafuku S, Kawashima M, Ohtsuki M, Fujita H, Arima K, Takagi H, Chen Z, Shumel B, Ardeleanu M Tags: Br J Dermatol Source Type: research

Validation of the Dutch Quality of Life in Hand Eczema Questionnaire (QOLHEQ).
CONCLUSION: The Dutch version of the QOLHEQ has a good structural validity and reproducibility and has a high single-score validity and moderate responsiveness. An improvement of ≥15 points should be regarded a real, important change within the Dutch population. PMID: 31560803 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 27, 2019 Category: Dermatology Authors: Oosterhaven JAF, Ofenloch RF, Schuttelaar MLA Tags: Br J Dermatol Source Type: research

IL-17C is Elevated in Lesional Tissue of Hidradenitis Suppurativa.
Abstract Interleukin 17C (IL-17C) is a cytokine produced by epithelial cells, including keratinocytes, in response to multiple stimuli1 such as IL-17A, IL-17F, TNF-α, bacterial stimuli and toll-like receptor agonists1 . When produced in keratinocytes, IL-17C mediates the production of inflammatory molecules, including IL-1β, IL-8, CXCL1, and IL-36γ. In addition, IL-17C induces further elevation in IL-17A and IL-17F in Th17 cells in a pro-inflammatory positive amplification loop2,3 . PMID: 31556100 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 26, 2019 Category: Dermatology Authors: Navrazhina K, Frew JW, Krueger JG Tags: Br J Dermatol Source Type: research

EBGene trial: Patient pre-selection outcomes for the European GENEGRAFT ex vivo phase I/II gene therapy trial for recessive dystrophic epidermolysis bullosa.
Abstract Recessive dystrophic epidermolysis bullosa (RDEB) is an inherited skin fragility disorder caused by loss-of-function mutations in COL7A1 encoding type VII collagen (C7), the major component of anchoring fibrils (AFs) that ensure dermal-epidermal adherence. From birth, RDEB patients endure lifelong skin and mucosal blistering with both local and systemic complications including aggressive metastatic squamous cell carcinomas (SCC).1 Currently, treatments are only symptomatic although clinical studies of novel therapeutics, including gene2 and cell3 therapies are emerging. One potential safety issue with suc...
Source: The British Journal of Dermatology - September 26, 2019 Category: Dermatology Authors: Gaucher S, Lwin SM, Titeux M, Abdul-Wahab A, Pironon N, Izmiryan A, Miskinyte S, Ganier C, Duchatelet S, Mellerio JE, Bourrat E, McGrath JA, Hovnanian A Tags: Br J Dermatol Source Type: research

Pain severity and use of analgesic medication in adults with atopic dermatitis: a cross-sectional study.
CONCLUSION: Patients with AD did not display increased use of pain medication but few had severe disease. The close observed relationship between itch and pain, highlights the potential benefits of established AD treatments to also reduce skin pain in AD. PMID: 31556099 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 25, 2019 Category: Dermatology Authors: Thyssen JP, Halling-Sønderby AS, Wu JJ, Egeberg A Tags: Br J Dermatol Source Type: research

Trends in epidemiology of melanoma in situ in Greece: Data from a melanoma reference center during the period 2000-2018.
Abstract The incidence of melanoma in situ (MIS) is increasing more rapidly than this of invasive,1 . According to SEER database it represents one of the most fast-growing malignancies2 . Reported data from South Europe mostly include information from Italy and Spain3 . We tried to study the epidemiological trends of MIS in Greece. PMID: 31549388 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 23, 2019 Category: Dermatology Authors: Kostaki M, Plaka M, Stergiopoulou A, Kypreou K, Chardalia V, Chasapi V, Polydorou D, Stratigos A Tags: Br J Dermatol Source Type: research

Acquired epidermodysplasia verruciformis: a ten-year anniversary update.
Abstract Epidermodysplasia verruciformis (EV), a rare dermatologic condition, was first described by Lewandosky and Lutz in 1922. Subsequently, the disease was linked to nonsense mutations in EVER1 and EVER2 which were proposed to enhance susceptibility to EV-specific β-human papillomavirus (HPV) subtypes. However, genetic alterations alone did not adequately explain the propensity for EV to arise in immunocompromised patients, especially those who are human immunodeficiency virus (HIV)-positive or who have undergone transplantation. PMID: 31545504 [PubMed - as supplied by publisher] (Source: The British...
Source: The British Journal of Dermatology - September 23, 2019 Category: Dermatology Authors: Limmer AL, Wu JH, Doan HQ, Rady PL, Tyring SK Tags: Br J Dermatol Source Type: research

An indirect comparison of long-term efficacy of every-two-week dosing versus recommended dosing of ixekizumab in patients who had sPGA > 1 at week 12.
CONCLUSIONS: Among patients who did not have clear or almost clear skin at Week 12, nearly 30% more patients treated continuously with ixekizumab Q2W in IXORA-P had clear or almost clear skin at Week 52 when compared indirectly with those treated with labeled psoriasis dosing in integrated UNCOVER studies. PMID: 31545506 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 23, 2019 Category: Dermatology Authors: Papp K, Maari C, Cauthen A, Gooderham M, Spelman L, Yamanaka K, Polzer P, Zhang L, Osuntokun O, Augustin M Tags: Br J Dermatol Source Type: research

Long-term efficacy and safety of sonidegib in patients with advanced basal cell carcinoma: 42-month analysis of the phase 2 randomised, double-blind BOLT study.
CONCLUSIONS: Sonidegib demonstrated sustained efficacy and a manageable safety profile. Final BOLT results support sonidegib as a viable treatment option for laBCC and mBCC. PMID: 31545507 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 23, 2019 Category: Dermatology Authors: Dummer R, Guminksi A, Gutzmer R, Lear JT, Lewis KD, Chang ALS, Combemale P, Dirix L, Kaatz M, Kudchadkar R, Loquai C, Plummer R, Schulze HJ, Stratigos AJ, Trefzer U, Squittieri N, Migden MR Tags: Br J Dermatol Source Type: research

Post-traumatic stress disorder in patients with autoimmune blistering diseases.
Abstract Post-Traumatic Stress Disorder (PTSD) can develop when an individual has an experience that threatens their psychological or physical integrity.1 PTSD has been observed in patients with sudden-onset, life-altering or life-threatening health conditions ranging from cancer and asthma2,3 to Stevens-Johnson Syndrome,4 but has not been evaluated in chronic, relapsing inflammatory dermatologic diseases such as autoimmune bullous disease. PTSD may also directly impact immune function and a wide range of immune based disorders; previous studies of PTSD patients have reported a higher prevalence of autoimmune diso...
Source: The British Journal of Dermatology - September 23, 2019 Category: Dermatology Authors: Wei EX, Li SJ, Mostaghimi A Tags: Br J Dermatol Source Type: research

Successful treatment of recalcitrant plantar warts by carbon dioxide laser with a computerized scanner.
Abstract Warts are benign neoplasms of the skin and mucosa caused by human papillomavirus (HPV) infection.1 The most common treatments for wart are topical application of salicylic acid and cryotherapy. Other modalities include chemical agents, contact sensitizing agents and surgical excision.2 Laser modalities, including carbon dioxide (CO2 ), pulsed dye and neodymium-doped: yttrium-aluminum-garnet lasers, have also been used to treat recalcitrant plantar warts. PMID: 31545511 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 23, 2019 Category: Dermatology Authors: Kagoyama K, Makino T, Shimizu T Tags: Br J Dermatol Source Type: research

Patient-reported health not associated with keratinocyte carcinoma treatment choice in a Medicare cohort of older adults.
Abstract Keratinocyte carcinomas (KCs; basal cell carcinoma [BCC] and squamous cell carcinoma [SCC]), are common in older adults, with 2.1 million yearly in United States (US) Medicare patients.1 Common treatments include destruction (typically electrodessication and curettage), surgical excision, and Mohs micrographic surgery (MMS), all of which can offer cure rates>90%2,3 (highest for MMS, followed by excision, then destruction). PMID: 31539166 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 20, 2019 Category: Dermatology Authors: Wehner MR, Kwong PL, Kurichi JE, Xie D, Hennessy S, Margolis DJ Tags: Br J Dermatol Source Type: research

Nosocomial outbreak of crusted scabies in immunosuppressed patients caused by Sarcoptes scabiei var. canis.
We report a nosocomial outbreak of crusted scabies due to S. scabiei var. canis in immunosuppressed patients. PMID: 31535362 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 19, 2019 Category: Dermatology Authors: Stingeni L, Tramontana M, Principato M, Moretta I, Principato S, Bianchi L, Hansel K Tags: Br J Dermatol Source Type: research

The sentinel node biopsy has not come of age (cover page).
Abstract We are stunned that Dr Jane McGregor believes that "The sentinel node biopsy (SLNB) has come of age" [1]. We do not accept this claim. SLNB is still younger and less experienced than the pathological criteria of Breslow thickness and ulceration. SLNB provides no survival benefit for melanoma patients [2] and results in complications, including 6% risk of lymphoedema [2]. The vast majority of melanoma patients have negative SLNB and cannot possibly benefit from the procedure. PMID: 31536641 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 19, 2019 Category: Dermatology Authors: Sladden M, Zagarella S, Popescu C, Bigby M Tags: Br J Dermatol Source Type: research

Evaluation of haematopoietic stem cell transplantation in patients diagnosed with cutaneous T cell lymphoma at a tertiary care centre: Should we avoid chemotherapy in conditioning regimes?
Abstract Advanced stage mycosis fungoides (MF) and Sézary syndrome (SS) account for ~30% of patients with cutaneous T-cell lymphomas (CTCL). The prognosis is poor with a median survival of 36 months.1 Treatments rarely result in durable remissions and recent management guidelines recommend allogeneic haematopoietic stem cell transplant (HSCT) for eligible patients as the best chance of improved survival. PMID: 31536644 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 19, 2019 Category: Dermatology Authors: Ritchie S, Qureshi I, Molloy K, Yoo J, Shah F, Stevens A, Irwin C, Chaganti S, Scarisbrick JJ Tags: Br J Dermatol Source Type: research