A Head-to-Head Comparison of Ixekizumab Versus Guselkumab in Patients with Moderate-to-Severe Plaque Psoriasis: 12-Week Efficacy, Safety, and Speed of Response from a Randomized, Double-Blinded Trial.
Abstract BACKGROUND: Patients with psoriasis value rapid and complete skin clearance. No head-to-head studies have focused on early responses to interleukin (IL)-17 versus IL-23 inhibitors. OBJECTIVES: To compare early and complete skin clearance by the IL-17A inhibitor ixekizumab versus the IL-23p19 inhibitor guselkumab. METHODS: IXORA-R, a 24-week, randomised, double-blinded study, enrolled adults with moderate-to-severe plaque psoriasis (static Physician's Global Assessment of Disease [sPGA] score of ≥3, Psoriasis Area and Severity Index [PASI] ≥12, and ≥10% body surface area). Patients were ...
Source: The British Journal of Dermatology - December 29, 2019 Category: Dermatology Authors: Blauvelt A, Papp K, Gottlieb A, Jarell A, Reich K, Maari C, Gordon KB, Ferris LK, Langley RG, Tada Y, Lima RG, Elmaraghy H, Gallo G, Renda L, Park SY, Burge R, Bagel J, IXORA-R Study Group Tags: Br J Dermatol Source Type: research

Hidradenitis suppurativa and infections.
PMID: 31885072 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 28, 2019 Category: Dermatology Authors: Kridin K, Cohen AD Tags: Br J Dermatol Source Type: research

Psoriasis and atopic dermatitis: different entities with unsolved challenges.
PMID: 31885075 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 28, 2019 Category: Dermatology Authors: Megna M, Fabbrocini G Tags: Br J Dermatol Source Type: research

Oral ivermectin for infants and children under 15 kg appears to be a safe and effective treatment for scabies.
PMID: 31885077 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 28, 2019 Category: Dermatology Authors: Morris-Jones R Tags: Br J Dermatol Source Type: research

Dupilumab as a treatment for generalized idiopathic pruritus: a report of 2 cases.
Abstract Chronic pruritus markedly impairs quality of life has been compared to living with chronic pain (1). Generalized pruritus can be associated with underlying medical diseases or be deemed idiopathic (1). Regarding idiopathic pruritus, guidelines published by the British Association of Dermatologists state that, "various systemic treatments have been used, however, no randomized controlled trials have found any one therapy to be effective and safe" (2). Novel topical agents such as crisaborole are safer than long-term use of corticosteroids, but many patients require systemic therapy. (3) Dupilumab...
Source: The British Journal of Dermatology - December 27, 2019 Category: Dermatology Authors: Stanger R, Rivera-Oyola R, Lebwohl M Tags: Br J Dermatol Source Type: research

Topical Corticosteroids and Type 2 Diabetes Mellitus: A Critical Appraisal.
Abstract Topical corticosteroids are widely used to treat inflammatory or pruritic skin conditions. The impact of systemic absorption of topical corticosteroids on the risk of hyperglycemia, and subsequent type 2 diabetes is unclear. Andersen et al. aimed to determine if topical corticosteroid use for psoriasis and eczema,1 which affect 2-3% and 2-8% of adults worldwide, respectively, is associated with an increased risk of newly-diagnosed type 2 diabetes.2,3. PMID: 31883374 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 27, 2019 Category: Dermatology Authors: Wong L, Tadrous M Tags: Br J Dermatol Source Type: research

Profiling the human hair follicle immune system in lichen planopilaris and frontal fibrosing alopecia: Can macrophage polarization differentiate these two conditions microscopically?
CONCLUSIONS: This comparative immunopathology analysis is the first to systematically profile the HIS in LPP and FFA. Our analysis highlights a potential role of macrophages in disease pathobiology and suggests that macrophage polarization may differ between LPP and FFA allowing microscopic differentiation. PMID: 31883384 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 27, 2019 Category: Dermatology Authors: Harries M, Hardman J, Chaudhry I, Poblet E, Paus R Tags: Br J Dermatol Source Type: research

Identifying Barriers to Care and Research in Hidradenitis Suppurativa: Findings from a Patient Engagement Event.
Abstract Hidradenitis Suppurativa (HS) is a painful, disfiguring chronic inflammatory disease that disproportionately affects underserved populations. Delayed diagnosis1 and lack of uniformly effective therapies2, 3 have contributed to HS patient suffering, despair, and reluctance to seek healthcare and participate in research. In recent years, over 60,000 patients have found support and health information through Facebook communities. PMID: 31883104 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 26, 2019 Category: Dermatology Authors: Shukla N, Paul M, Halley M, Lowes MA, Hester V, Aguilar C, Guilbault S, Long TS, Taylor A, Thompson AC, Yannuzzi CA, Linos E, Naik HB Tags: Br J Dermatol Source Type: research

Image Gallery: Neglected skin cancer in an elderly patient with cognitive impairment.
PMID: 31879939 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 25, 2019 Category: Dermatology Authors: Kearney N, Gallagher C, Lally A Tags: Br J Dermatol Source Type: research

Image Gallery: Palmar vascular lesions, a tool for diagnosis and prognosis in Fabry disease.
PMID: 31875942 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 24, 2019 Category: Dermatology Authors: Fredeau L, Karaa S, London J, Matignon MB, Blah N, Montagner C, Lidove O, Mauhin W Tags: Br J Dermatol Source Type: research

Pachyonychia congenita and botulinum toxin.
PMID: 31875943 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 24, 2019 Category: Dermatology Authors: Thomas BR, Sahota A Tags: Br J Dermatol Source Type: research

The skin myositis Delphi group puts the details in 'skin-predominant' dermatomyositis.
PMID: 31875944 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 24, 2019 Category: Dermatology Authors: Fernandez AP Tags: Br J Dermatol Source Type: research

Sodium lauryl sulfate: a never ending story?
PMID: 31875945 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 24, 2019 Category: Dermatology Authors: Agner T, Elsner P Tags: Br J Dermatol Source Type: research

Real-world evidence vs. randomized control trials.
PMID: 31875946 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 24, 2019 Category: Dermatology Authors: Deleuran M, Vestergaard C Tags: Br J Dermatol Source Type: research

'COre SUBgroup SETs (COSUBSET)' initiative is needed.
PMID: 31875947 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 24, 2019 Category: Dermatology Authors: Sbidian E, Le Cleach L Tags: Br J Dermatol Source Type: research

Fluoxetine promotes human hair follicle pigmentation ex vivo: Serotonin re-uptake inhibition as a new anti-greying strategy?
aus R Abstract The commonly prescribed anti-depressant, fluoxetine, has been reported to (rarely) induce epidermal hyperpigmentation after systemic application1 . This selective serotonin reuptake inhibitor (SSRI) also can stimulate melanin production in murine hair follicles (HFs) in vivo under conditions of perceived stress and in cultured human epidermal melanocytes in vitro2,3 . Given the distinct neuroendocrine controls that human HF melanocytes underlie compared to epidermal melanocytes4 and that any pigmentary effects of fluoxetine observed in vivo may have been indirectly mediated, it has as yet remained e...
Source: The British Journal of Dermatology - December 22, 2019 Category: Dermatology Authors: Chéret J, Gherardini J, Bertolini M, Paus R Tags: Br J Dermatol Source Type: research

The intriguing association between smoking and reduced melanoma risk.
PMID: 31872423 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 22, 2019 Category: Dermatology Authors: Thompson JF, Friedman EB Tags: Br J Dermatol Source Type: research

Modeling the Value of Risk Stratified Skin Cancer Screening of Asymptomatic Patients by Dermatologists.
CONCLUSION: Incidental skin cancers are detected by screening TBSE and its value can be enhanced through consideration of patients' age and SPT, which are established and readily identifiable skin cancer risk factors. PMID: 31867714 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 21, 2019 Category: Dermatology Authors: Hartman RI, Xue Y, Singer S, Markossian TW, Joyce C, Mostaghimi A Tags: Br J Dermatol Source Type: research

Image Gallery: Onychomadesis in linear IgA bullous dermatosis.
PMID: 31867716 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 21, 2019 Category: Dermatology Authors: Wang H, Wang X, Yang B, Liu H, Zhang F Tags: Br J Dermatol Source Type: research

User-friendly classification to achieve patient-friendly outcomes.
PMID: 31863473 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 19, 2019 Category: Dermatology Authors: Vitoriano AM Tags: Br J Dermatol Source Type: research

Systematic reviews in dermatology: opportunities for improvement.
PMID: 31863474 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 19, 2019 Category: Dermatology Authors: Barbieri JS, Wehner MR Tags: Br J Dermatol Source Type: research

Everyday sunscreen use may compromise vitamin D in temperate climes: reply from authors.
Abstract de Gruijl and colleagues make an excellent point1 and we thank them for their interest in our paper.2 Summaries are restricted by word limits and we accept that judgement on sunscreen use is necessary, depending on the local ultraviolet index (UVI) and sun exposure behaviour. UVI, and solar UVB radiation (~295-315nm) necessary for vitamin D synthesis, decrease with increasing latitude. PMID: 31858587 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 19, 2019 Category: Dermatology Authors: Young AR, Passeron T Tags: Br J Dermatol Source Type: research

Influence of family history on risk of second primary cancers and survival in squamous cell skin cancer patients.
CONCLUSION: Family history of non-skin cancer was associated with approximately a doubling of risk for SPCs in SCC patients. SPC increases the death rate in SCC patients 3 to 4 times, irrespective of family history. Taking family history into account at SCC diagnosis may help prevention or early detection of SPCs. PMID: 31853941 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 18, 2019 Category: Dermatology Authors: Chattopadhyay S, Zheng G, Hemminki A, Försti A, Sundquist K, Sundquist J, Hemminki K Tags: Br J Dermatol Source Type: research

Everyday sunscreen use may compromise vitamin D in temperate climes.
Abstract The continuing increase in skin cancer incidence has not been curbed by campaigns raising people's awareness of the risks of habitual excessive sun-exposure. An approach to combat this which appears to be gaining momentum is to promote rigorous sunscreen use. PMID: 31853945 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 18, 2019 Category: Dermatology Authors: De Gruijl FR, Webb AR, Rhodes LE Tags: Br J Dermatol Source Type: research

Skin cancer multiplicity in lung transplant recipients: prospective, population-based study.
CONCLUSIONS: Lung transplant recipients have very high incidence of multiple primary skin cancers. Close surveillance and assiduous prevention measures are essential. PMID: 31853948 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 18, 2019 Category: Dermatology Authors: Way M, Marquart L, Chambers DC, Hopkins P, Miura K, Jiyad Z, Plasmeijer EI, Ferguson LE, Davis M, Whiteman DC, Soyer HP, O'Rourke P, Green AC Tags: Br J Dermatol Source Type: research

Psoriasin (S100A7) is increased in serum of patients with moderate to severe psoriasis.
Abstract Psoriasis is a chronic immune-mediated inflammatory disease affecting 2-3% of Caucasian population. Several inflammatory mediators in patient samples have been associated with psoriasis and its comorbidities. Psoriasin (S100A7), a proinflammatory protein belonging to the S100 family of small calcium-binding proteins, is produced by epidermal keratinocytes and peripheral leukocytes and is significantly overexpressed in psoriasis. PMID: 31853957 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 18, 2019 Category: Dermatology Authors: Maurelli M, Gisondi P, Danese E, Gelati M, Papagrigoraki A, Del Giglio M, Lippi G, Girolomoni G Tags: Br J Dermatol Source Type: research

Effectiveness of Brentuximab vedotin before and after allogeneic stem cell transplantation in the management of transformed mycosis fungoides.
son A Abstract Brentuximab vedotin (BV) is an antibody-drug conjugate, composed of a humanized anti-CD30 IgG1 and of the anti-mitotic monomethyl auristatine E1 . The interest of BV in the management of CD30-positive mycosis fungoides (MF) and primary cutaneous anaplastic large cell lymphoma has recently been demonstrated compared to methotrexate or bexarotene. PMID: 31854457 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 18, 2019 Category: Dermatology Authors: André R, Ram-Wolff C, Battistella M, de Latour RP, Petit A, Bouaziz JD, Brice P, Bagot M, de Masson A Tags: Br J Dermatol Source Type: research

Predicting keratinocyte carcinoma in patients with actinic keratosis: development and internal validation of a multivariable risk prediction model.
CONCLUSIONS: We showed that the risk of KC in patients with AK can be calculated with the use of four easily assessable predictor variables. Given the c-index, extension of the model with additional, currently unknown predictor variables is desirable. PMID: 31856292 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 18, 2019 Category: Dermatology Authors: Tokez S, Alblas M, Nijsten T, Pardo Cortes LM, Wakkee M Tags: Br J Dermatol Source Type: research

Stevens-Johnson syndrome/toxic epidermal necrolysis: a chronic condition?
PMID: 31853947 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 17, 2019 Category: Dermatology Authors: Lee HY, Creamer D Tags: Br J Dermatol Source Type: research

Response to R. Waldman, M.E. DeWane, S. Brett Sloane: "Letter in Reply - Does IL-4 inhibition play a role in dupilumab-associated conjunctivitis?"
Response to R. Waldman, M.E. DeWane, S. Brett Sloane: "Letter in Reply - Does IL-4 inhibition play a role in dupilumab-associated conjunctivitis?" Br J Dermatol. 2019 Dec 18;: Authors: Ardeleanu M, Shumel B, Rossi AB, Graham NMH Abstract Bakker et al. proposed that interleukin (IL)-13 inhibition-induced goblet cell decline drives dupilumab-associated conjunctivitis in atopic dermatitis (AD).1 In response, Waldman et al.2 suggested that IL-4 inhibition is essential, citing TREBLE, a randomized, 12-week, placebo-controlled, dose-ranging phase 2 trial of lebrikizumab (anti-IL-13 monoclonal anti...
Source: The British Journal of Dermatology - December 17, 2019 Category: Dermatology Authors: Ardeleanu M, Shumel B, Rossi AB, Graham NMH Tags: Br J Dermatol Source Type: research

Image Gallery: Cerebral and subcutaneous sparganosis.
PMID: 31853961 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 17, 2019 Category: Dermatology Authors: Adler BL, Kim GH, Kim DD Tags: Br J Dermatol Source Type: research

Remember to assess the 'whole' patient: a further immune-related adverse event of programmed cell death 1 checkpoint inhibition.
PMID: 31850528 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 17, 2019 Category: Dermatology Authors: Hunter HJA Tags: Br J Dermatol Source Type: research

Image Gallery: Haematogenous metastasis of melanoma mimicking lymphangioma.
eiro M, Bañuls J PMID: 31845311 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 16, 2019 Category: Dermatology Authors: Docampo-Simón A, Sánchez-Pujol MJ, Belinchón-Romero I, Niveiro M, Bañuls J Tags: Br J Dermatol Source Type: research

Hedgehog pathway inhibitors come of age.
PMID: 31849041 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 16, 2019 Category: Dermatology Authors: Fife K Tags: Br J Dermatol Source Type: research

WHO can decrease indoor tanning?
PMID: 31849050 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 16, 2019 Category: Dermatology Authors: Wehner MR Tags: Br J Dermatol Source Type: research

Image Gallery: Palmar and finger vein thrombosis associated with metastatic colorectal cancer.
PMID: 31849052 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 16, 2019 Category: Dermatology Authors: Morgado-Carrasco D, Escoda M Tags: Br J Dermatol Source Type: research

A multinational assessment of work-related productivity loss and indirect costs from a survey of patients with psoriasis.
Abstract BACKGROUND: Total work productivity loss (WPL) and associated indirect costs contribute to the economic burden of psoriasis. OBJECTIVE: To estimate total WPL and related indirect costs, and identify predictors of WPL associated with psoriasis severity in France, Germany, Spain, the UK and Italy (EU5) and the USA. METHODS: Data from the 2015 Adelphi Real World Psoriasis Disease Specific Programme, analysed for absenteeism, presenteeism and total WPL, were quantified (0-100%) from participants that completed the Work Productivity and Activity Impairment (WPAI) instrument. These measures were conve...
Source: The British Journal of Dermatology - December 15, 2019 Category: Dermatology Authors: Villacorta R, Teeple A, Lee S, Fakharzadeh S, Lucas J, McElligott S Tags: Br J Dermatol Source Type: research

Noninferiority of biosimilar MSB110222 to reference adalimumab for chronic plaque psoriasis.
PMID: 31840231 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 14, 2019 Category: Dermatology Authors: Borroni RG, Costanzo A Tags: Br J Dermatol Source Type: research

Patient recall may be of limited use in establishing the clinical relevance of positive patch test reactions (to fragrances).
PMID: 31840234 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 14, 2019 Category: Dermatology Authors: Uter W Tags: Br J Dermatol Source Type: research

Effect of Sunscreen Application Under Maximal Use Conditions on Plasma Concentration of Sunscreen Active Ingredients: A Critical Appraisal.
Abstract Matta KM et al1 conducted a Phase 1 randomised controlled trial (RCT) to investigate whether four organic UVR filters in four commercially available sunscreens (2 sprays, 1 lotion, 1 cream) were systemically absorbed after four daily applications for four days. The filters were avobenzone (2-3%), oxybenzone (0-6%), octocrylene (2.35-10%) and ecamsule (2%). Plasma concentrations>0.5 ng/mL were reached on day one for all four filters, exceeding the threshold established by the US Food and Drug Administration (FDA). PMID: 31834937 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 12, 2019 Category: Dermatology Authors: Charalambides M, Kibbi N, Young AR Tags: Br J Dermatol Source Type: research

Self-reported naevus density may lead to misclassification of melanoma risk.
Abstract Cutaneous melanoma incidence continues to rise, imposing a sizable burden on health services and society1 . The strongest known risk factor for melanoma is the presence of many melanocytic naevi2 . Naevus prevalence studies use a variety of counting methods from objective counts by dermatologists or research staff, to self-counts. This diversity likely contributes to the variation seen in prevalence estimates3 . Expert counts are more accurate but are labour-intensive and costly. PMID: 31833052 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 11, 2019 Category: Dermatology Authors: Betz-Stablein B, Koh U, Plasmeijer E, Janda M, Aitken JF, Soyer HP, Green AC Tags: Br J Dermatol Source Type: research

Psoriasis Area and Severity Index vs. pharmacokinetics: can monitoring 4-week postinjection ustekinumab concentrations in patients with suboptimal response be clinically relevant?
PMID: 31828758 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 10, 2019 Category: Dermatology Authors: Puig L Tags: Br J Dermatol Source Type: research

Psoriatic epidermis expresses high level of inflammatory mediators and the CDK2/4 cyclin-dependent kinases are involved in the regulation of cell-cycle progression in epidermal cells.
PMID: 31828762 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 10, 2019 Category: Dermatology Authors: Gesser B, Rasmussen MK Tags: Br J Dermatol Source Type: research

Quality of life, Skindex-29, mycosis fungoides/S ézary syndrome.
Quality of life, Skindex-29, mycosis fungoides/Sézary syndrome. Br J Dermatol. 2019 Dec 11;: Authors: Talpur R PMID: 31828764 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 10, 2019 Category: Dermatology Authors: Talpur R Tags: Br J Dermatol Source Type: research

Tissue-specific personalized medicine: the next level of individualized treatment.
PMID: 31828766 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 10, 2019 Category: Dermatology Authors: Ludwig RJ Tags: Br J Dermatol Source Type: research

Role of senescent fibroblasts in the development of idiopathic guttate hypomelanosis.
CONCLUSIONS: Senescent fibroblasts might contribute to the development of IGH through induction of melanocyte senescence and apoptosis in melanocytes via SASP. PMID: 31823346 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 9, 2019 Category: Dermatology Authors: Kim JY, Lee SH, Ahn Y, Lee EJ, Park MY, Hwang S, Almurayshid A, Lim BJ, Oh SH Tags: Br J Dermatol Source Type: research

Revisiting pachyonychia congenita: a case-cohort study of 815 patients.
CONCLUSIONS: Here, we establish phenotype-genotype correlations in the largest cohort of PC patients described to date and reveal novel and clinically useful predictors of disease course and manifestations. PMID: 31823354 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 9, 2019 Category: Dermatology Authors: Samuelov L, Smith FJD, Hansen CD, Sprecher E Tags: Br J Dermatol Source Type: research

Epidemiology of juvenile dermatomyositis in Alsace.
Abstract Juvenile dermatomyositis (JDM) is a rare inflammatory myopathy. 1 Little reliable data is available on epidemiology of JDM.This is an observational, retrospective, multicenter study, using the capture-recapture method to assess incidence and prevalence of JDM in Alsace, a French region with a low migratory rate. Only patients, aged 0 to 16 years, having JDM according to the Bohan and Peter criteria 2 and the EULAR/ACR criteria 3 , were included. Overlap syndromes were excluded. Seven sources were used: hospital dermatologists and pediatricians, their counterparts in private practice, hospital rheumatologi...
Source: The British Journal of Dermatology - December 9, 2019 Category: Dermatology Authors: Moegle C, Severac F, Lipsker D Tags: Br J Dermatol Source Type: research

Enhanced Topical Psoralen-UV-A Therapy via Targeting to Hair Follicles.
Abstract The renewed interest in Psoralen-UV-A (PUVA) therapy driven by impressive recent results in this field encourages the researchers and clinicians to shift the momentum back in its favor.1-3 As far as administration of low-cumulative UV-A doses minimizes the negative risks, the search for efficient modalities decreasing the frequency of sessions may help not to lose such therapeutic option. PMID: 31821544 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 9, 2019 Category: Dermatology Authors: Svenskaya YI, Talnikova EE, Parakhonskiy BV, Tuchin VV, Sukhorukov GB, Gorin DA, Utz SR Tags: Br J Dermatol Source Type: research

Current mysteries of pachyonychia congenita.
PMID: 31814103 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - December 7, 2019 Category: Dermatology Authors: Leube RE, Schwarz N Tags: Br J Dermatol Source Type: research