Cancer is not a risk factor for bullous pemphigoid. A ten-year population-based cohort study.
CONCLUSIONS: The incidence of BP in the cancer patients was not higher than in the controls. Cancer is not a risk factor for BP. This article is protected by copyright. All rights reserved. PMID: 30216411 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 14, 2018 Category: Dermatology Authors: Chen CT, Hu HY, Chang YT, Li CP, Wu CY Tags: Br J Dermatol Source Type: research

Sensitive and specific assay for the serological diagnosis of anti-laminin 332 mucous membrane pemphigoid.
CONCLUSION: The novel IF-based assay will facilitate the serological diagnosis of anti-laminin 332 MMP and may help to identify patients at risk of a malignancy. This article is protected by copyright. All rights reserved. PMID: 30216412 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 14, 2018 Category: Dermatology Authors: Goletz S, Probst C, Komorowski L, Schlumberger W, Fechner K, van Beek N, Holtsche MM, Recke A, Yancey KB, Hashimoto T, Antonicelli F, Di Zenzo G, Zillikens D, Stöcker W, Schmidt E Tags: Br J Dermatol Source Type: research

The utility of optical coherence tomography for diagnosis of basal cell carcinoma: A quantitative review.
Abstract BACKGROUND: Optical coherence tomography (OCT) is a non-invasive near-infrared light imaging technology that can be utilized to diagnose basal cell carcinomas (BCCs) based on specific morphologic features. OBJECTIVES: To conduct a quantitative review using tumor level data from published studies to assess i) in-vivo diagnostic accuracy of different OCT systems; ii) correlation between OCT features and histopathological diagnosis; and iii) factors that impact accuracy of tumor depth estimation. METHODS: Primary tumor-level data were extracted from published studies on use of time-domain (TD-OCT),...
Source: The British Journal of Dermatology - September 14, 2018 Category: Dermatology Authors: Reddy N, Nguyen BT Tags: Br J Dermatol Source Type: research

GM-CSF as a therapeutic target in psoriasis: randomised, controlled investigation using namilumab - a specific, human anti-GM-CSF monoclonal antibody.
CONCLUSIONS: GM-CSF blockade is not critical for suppression of key inflammatory pathways underlying psoriasis (NCT02129777). This article is protected by copyright. All rights reserved. PMID: 30207587 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 12, 2018 Category: Dermatology Authors: Papp KA, Gooderham M, Jenkins R, Vender R, Szepietowski JC, Wagner T, Hunt B, Souberbielle B, NEPTUNE investigators Tags: Br J Dermatol Source Type: research

Variation in daily ultraviolet light exposure and sun protection behaviours of melanoma survivors: an observational single-arm pilot study with a wearable sensor.
This article is protected by copyright. All rights reserved. PMID: 30207589 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 12, 2018 Category: Dermatology Authors: Xu S, Stump TK, Jain J, Alshurafa N, Robinson JK Tags: Br J Dermatol Source Type: research

Diagnostic Accuracy of Content Based Dermatoscopic Image Retrieval with Deep Classification Features.
CONCLUSIONS: Presenting visually similar images based on features from a neural network shows comparable accuracy to the softmax probability-based diagnoses of convolutional neural networks. CBIR may be more helpful than a softmax classifier in improving diagnostic accuracy of clinicians in a routine clinical setting. This article is protected by copyright. All rights reserved. PMID: 30207594 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 12, 2018 Category: Dermatology Authors: Tschandl P, Argenziano G, Razmara M, Yap J Tags: Br J Dermatol Source Type: research

Reference method for digital surface measurement of target lesions in vitiligo: a comparative analysis.
CONCLUSION: This study confirmed the reliability, validity and feasibility of two functions in ImageJ to measure target lesions in vitiligo. Based on feasibility and included 3D aspects, transparent sheets measured with the ImageJ 'Wand' function can be proposed for future trials as a reference method to investigate the criterion validity of other digital instruments. This article is protected by copyright. All rights reserved. PMID: 30207606 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 12, 2018 Category: Dermatology Authors: van Geel N, Vandendriessche D, Vandersichel E, De Schepper S, Grine L, Mertens L, Vandaele V, Spoelders F, Bekkenk M, Wolkerstorfer A, Prinsen CA, Speeckaert R Tags: Br J Dermatol Source Type: research

Recurrence rate of cutaneous squamous cell carcinoma of the head and neck after Mohs micrographic surgery versus standard excision: a retrospective cohort study.
CONCLUSIONS: MMS might be superior to SE for cSCCs of the head and neck due to less recurrences. This article is protected by copyright. All rights reserved. PMID: 30199574 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 10, 2018 Category: Dermatology Authors: van Lee CB, Roorda BM, Wakkee M, Voorham Q, Mooyaart AL, de Vijlder HC, Nijsten T, Van den Bos RR Tags: Br J Dermatol Source Type: research

Image gallery: Hairy-cell leukaemia presenting with Sweet syndrome.
This article is protected by copyright. All rights reserved. PMID: 30194758 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 8, 2018 Category: Dermatology Authors: Shah PR, Scott G, Beck LA Tags: Br J Dermatol Source Type: research

Cost-savings of adalimumab in hidradenitis suppurativa: A retrospective analysis of a real-world cohort.
CONCLUSIONS: Treatment with anti-TNFs achieves significant cost-benefit through containment of HS exacerbations. The efficacy of anti-TNFs was similar for both disease stages. This article is protected by copyright. All rights reserved. PMID: 30192377 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 7, 2018 Category: Dermatology Authors: Argyropoulou M, Kanni T, Kyprianou M, Melachroinopoulos N, Giamarellos-Bourboulis EJ Tags: Br J Dermatol Source Type: research

Photodynamic inactivation of bacteria to decolonize Methicillin resistant Staphylococcus aureus (MRSA) from human skin.
CONCLUSION: The results of this study show that PIB can effectively and safely kill bacteria like MRSA on skin surface and might have the potential of skin decolonization in vivo. This article is protected by copyright. All rights reserved. PMID: 30192389 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 7, 2018 Category: Dermatology Authors: Schreiner M, Bäumler W, Eckl D, Späth A, König B, Eichner A Tags: Br J Dermatol Source Type: research

A new clinical variant of acquired reactive perforating dermatosis-like bullous pemphigoid.
This article is protected by copyright. All rights reserved. PMID: 30188568 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 6, 2018 Category: Dermatology Authors: Schauer F, Kern JS, Virtic O, Technau-Hafsi K, Meiss F, Thoma K, Athanasiou I, Sitaru C, Di Zenzo G, Izumi K, Nishie W, Shimizu H, Bruckner-Tuderman L, Kiritsi D Tags: Br J Dermatol Source Type: research

Local interventions for actinic keratosis in organ transplant recipients: A systematic review.
CONCLUSIONS: Limited evidence is available for the treatment of AKs in OTRs. MAL-PDT is currently the best-studied intervention. Lesion-specific regimens may not be sufficient to achieve disease control. Field-directed regimens are preferable in this high-risk population. This article is protected by copyright. All rights reserved. PMID: 30188570 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 6, 2018 Category: Dermatology Authors: Heppt MV, Steeb T, Niesert AC, Zacher M, Leiter U, Garbe C, Berking C Tags: Br J Dermatol Source Type: research

Benefit-risk of tofacitinib in patients with moderate to severe chronic plaque psoriasis: Pooled analysis across 6 clinical trials.
CONCLUSION: Tofacitinib has a benefit-risk profile in moderate to severe psoriasis consistent with other systemic treatments. This article is protected by copyright. All rights reserved. PMID: 30188571 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 6, 2018 Category: Dermatology Authors: Strober BE, Gottlieb AB, van de Kerkhof PCM, Puig L, Bachelez H, Chouela E, Imafuku S, Thaçi D, Tan H, Valdez H, Gupta P, Kaur M, Frajzyngier V, Wolk R Tags: Br J Dermatol Source Type: research

"GENIPSO": a French prospective study assessing instantaneous prevalence, clinical features and impact on quality of life of genital psoriasis among patients consulting for psoriasis.
CONCLUSIONS: Genital psoriasis has a high prevalence in patients consulting for extra-genital psoriasis, affecting QOL, and should be better taken into account by dermatologists for optimizing global care. This article is protected by copyright. All rights reserved. PMID: 30188572 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 6, 2018 Category: Dermatology Authors: Larsabal M, Ly S, Sbidian E, Moyal-Barracco M, Dauendorffer JN, Dupin N, Richard MA, Chosidow O, Beylot-Barry M Tags: Br J Dermatol Source Type: research

Addition of oral mini pulse dexamethasone to NBUVB phototherapy and topical steroids helps arrest disease activity in patients with vitiligo.
This article is protected by copyright. All rights reserved. PMID: 30188576 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 6, 2018 Category: Dermatology Authors: Tovar-Garza A, Hinojosa JA, Hynan LS, Pandya AG Tags: Br J Dermatol Source Type: research

Eighth American Joint Committee on Cancer (AJCC) melanoma classification: what about stage IIC?
This article is protected by copyright. All rights reserved. PMID: 30187449 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 5, 2018 Category: Dermatology Authors: Brancaccio G, Napolitano S, Troiani T, Franco R, Iovino F, Reginelli A, Ciardiello F, Argenziano G Tags: Br J Dermatol Source Type: research

Cutaneous Mucormycosis caused by Mucor irregularis in a patient with CARD9 deficiency.
This article is protected by copyright. All rights reserved. PMID: 30187457 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 5, 2018 Category: Dermatology Authors: Wang X, Wang A, Wang X, Li R, Yu J Tags: Br J Dermatol Source Type: research

Etanercept biosimilar SB4 in the treatment of chronic plaque psoriasis. Data from the Psobiosimilars registry.
This article is protected by copyright. All rights reserved. PMID: 30187461 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 5, 2018 Category: Dermatology Authors: Gisondi P, Bianchi L, Calzavara-Pinton P, Conti A, Chiricozzi A, Fimiani M, Pellegrino M, Giunta A, Prignano F, Tiberio R, Venturini M, Girolomoni G Tags: Br J Dermatol Source Type: research

The Adverse Effects of Topical Photodynamic Therapy: a consensus review and approach to management.
This article is protected by copyright. All rights reserved. PMID: 30183065 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 5, 2018 Category: Dermatology Authors: Ibbotson SH, Wong TH, Morton CA, Collier NJ, Haylett A, McKenna KE, Mallipeddi R, Moseley H, Rhodes LE, Seukeran DC, Ward KA, Mohd Mustapa MF, Exton LS Tags: Br J Dermatol Source Type: research

Acute Exacerbation of Carpal Tunnel Syndrome After Radiesse ® Injection for Hand Rejuvenation.
This article is protected by copyright. All rights reserved. PMID: 30183067 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 5, 2018 Category: Dermatology Authors: Feig JL, Ho AM, Isseroff RR Tags: Br J Dermatol Source Type: research

Psychosocial impact of skin biopsies in the setting of melanoma screening - A cross-sectional survey.
This article is protected by copyright. All rights reserved. PMID: 30183068 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 5, 2018 Category: Dermatology Authors: Matthews NH, Risica PM, Ferris LK, Beatson M, Saul M, Geller AC, Solano F, Kirkwood JM, Weinstock MA Tags: Br J Dermatol Source Type: research

Skin involvement by chronic lymphocytic leukemia is frequently associated with unrelated neoplastic or inflammatory cutaneous disease and is not indicative of general disease progression.
This article is protected by copyright. All rights reserved. PMID: 30183072 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 5, 2018 Category: Dermatology Authors: Thiesen I, Wehkamp U, Brüggemann M, Ritgen M, Murga Penas EM, Klapper W, Oschlies I Tags: Br J Dermatol Source Type: research

Fingernail involvement in pemphigus and its correlation with disease severity and other clinico-demographic parameters.
This article is protected by copyright. All rights reserved. PMID: 30183085 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 5, 2018 Category: Dermatology Authors: De D, Kumar S, Handa S, Mahajan R Tags: Br J Dermatol Source Type: research

Skin type differences in solar simulated radiation-induced oxidative stress.
CONCLUSIONS: All spectral regions (UV, VIS and NIR) cause free radical formation in skin types II and IV-V. After 4 min of solar simulated exposure (UV-NIR), the radical formation in skin types IV-V is 60% of that in skin type II. Therefore darker skin types need solar protection, too. This article is protected by copyright. All rights reserved. PMID: 30176057 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 3, 2018 Category: Dermatology Authors: Albrecht S, Jung S, Müller R, Lademann J, Zuberbier T, Zastrow L, Reble C, Beckers I, Meinke MC Tags: Br J Dermatol Source Type: research

Lack of Confidence Interval Reporting in Dermatology: A Call to Action.
Abstract BACKGROUND: Confidence intervals (CIs) offer a complete and intuitive presentation of results and are more informative than p-values. The current prevalence of CI reporting in the dermatology literature has not been reported. OBJECTIVES: We evaluated CI reporting prevalence in the dermatology literature, factors predicting reporting, and compared CI reporting in the dermatology literature with dermatology research in the New England Journal of Medicine (NEJM). METHODS: MEDLINE® was queried for trials and observational studies published from 2007-2017 in six dermatology journals of varying im...
Source: The British Journal of Dermatology - September 1, 2018 Category: Dermatology Authors: Hopkins ZH, Moreno C, Secrest AM Tags: Br J Dermatol Source Type: research

Diagnostic heuristics in dermatology, Part 2: Metacognition and other fixes.
This article is protected by copyright. All rights reserved. PMID: 30171684 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2018 Category: Dermatology Authors: Lowenstein EJ, Sidlow R Tags: Br J Dermatol Source Type: research

Protection of glucotoxicity by a tripeptide derivative of α-melanocyte-stimulating hormone in human epidermal keratinocytes.
CONCLUSIONS: Our findings highlight a novel effect of KdPT which may be exploited for the future therapy of diabetic skin ulcers. This article is protected by copyright. All rights reserved. PMID: 30171686 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2018 Category: Dermatology Authors: Gkogkolou P, Sarna M, Sarna T, Paus R, Luger TA, Böhm M Tags: Br J Dermatol Source Type: research

Autoantibodies undetectable by chemiluminescent enzyme immunoassay require extended antigen-antibody reaction time for detection.
This article is protected by copyright. All rights reserved. PMID: 30171687 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2018 Category: Dermatology Authors: Mai Y, Ujiie H, Higashi T, Yamagami J, Iwata H, Shimizu H Tags: Br J Dermatol Source Type: research

Assessing the Severity of Pyoderma Gangrenosum - A Need for Validated Measurement Tools.
This article is protected by copyright. All rights reserved. PMID: 30171689 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2018 Category: Dermatology Authors: Dorrell DN, Huang WW Tags: Br J Dermatol Source Type: research

To what extent do disease severity and illness perceptions explain depression, anxiety and quality of life in Hidradenitis Suppurativa.
CONCLUSIONS: HS can severely impair psychological wellbeing and QoL which are more strongly associated with the person's beliefs about their illness compared to clinicians' severity assessments. Therefore, illness perceptions may be useful in the routine assessment of patients with HS and provide a strong basis for interventions aimed at improving their psychological wellbeing and QoL. This article is protected by copyright. All rights reserved. PMID: 30171696 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2018 Category: Dermatology Authors: Pavon Blanco A, Turner MA, Petrof G, Weinman J Tags: Br J Dermatol Source Type: research

Topical resiquimod dosing regimens in patients with multiple actinic keratosis: a multi-centre, partly placebo-controlled, double-blind, clinical trial.
This article is protected by copyright. All rights reserved. PMID: 30171698 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - September 1, 2018 Category: Dermatology Authors: Stockfleth E, Hofbauer GFL, Reinhold U, Popp G, Hengge UR, M Szeimies R, Brüning H, Anliker M, Hunger T, Dummer R, Ulrich C, Kenzelmann R, Surber C, French LE Tags: Br J Dermatol Source Type: research

A Milroy case with FLT4/VEGFR3 mutation and an unusual skin biopsy.
This article is protected by copyright. All rights reserved. PMID: 30169892 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 31, 2018 Category: Dermatology Authors: Liu NF, Yu ZY, Lou Y, Sun D Tags: Br J Dermatol Source Type: research

Comprehensive Long-Term Safety of Adalimumab from Eighteen Clinical Trials in Adult Patients With Moderate to Severe Plaque Psoriasis.
CONCLUSIONS: AE rates remained stable in this analysis of patients with psoriasis receiving adalimumab; no new safety signals were identified compared with earlier analyses. This article is protected by copyright. All rights reserved. PMID: 30169904 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 31, 2018 Category: Dermatology Authors: Leonardi C, Papp K, Strober B, Thaçi D, Warren RB, Tyring S, Arikan D, Karunaratne M, Valdecantos WC Tags: Br J Dermatol Source Type: research

Identifying demographic, social and clinical predictors of biologic therapy effectiveness in psoriasis: a multicentre longitudinal cohort study.
CONCLUSIONS: Psoriasis phenotype and potentially modifiable factors are associated with poor outcomes with biologics, underscoring the need for lifestyle management. Effect sizes suggest that these factors alone cannot inform treatment selection. PMID: 30155885 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 28, 2018 Category: Dermatology Authors: Warren RB, Marsden A, Tomenson B, Mason KJ, Soliman MM, Burden AD, Reynolds NJ, Stocken D, Emsley R, Griffiths CEM, Smith C, PSORT Consortium and on behalf of the BADBIR Study Group Tags: Br J Dermatol Source Type: research

Comorbidities or Different Entities? Phenotype Variability Associated with PSENEN Mutations.
This article is protected by copyright. All rights reserved. PMID: 30144026 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 24, 2018 Category: Dermatology Authors: Wenrui L, Haoxiang X, Yanyan H, Lin L, Chengrang L Tags: Br J Dermatol Source Type: research

Dermatological manifestations in cardiofaciocutaneous syndrome: A prospective multicentric study of 45 mutation-positive patients.
CONCLUSIONS: A thorough knowledge of CFCS skin manifestations would help in making a positive diagnosis and differentiating CFCS from CS and NS. This article is protected by copyright. All rights reserved. PMID: 30141192 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 23, 2018 Category: Dermatology Authors: Bessis D, Morice-Picard F, Bourrat E, Abadie C, Aouinti S, Baumann C, Best M, Bursztejn AC, Capri Y, Chiaverini C, Coubes C, Giuliano F, Hadj-Rabia S, Jacquemont ML, Lacombe D, Lyonnet S, Mallet S, Mazereeuw-Hautier J, Miquel J, Molinari N, Parfait B, Per Tags: Br J Dermatol Source Type: research

Systemic and stratum corneum biomarkers of severity in infant AD include markers of innate and Th-related immunity and angiogenesis.
CONCLUSIONS: We identified clinically relevant biomarkers of AD, including novel markers, easily sampled and typed in infants. These markers may provide objective assessment of disease severity and suggest new therapeutic targets, or response measurement targets for AD. Future studies will be required to determine if these biomarkers, seen in very early AD, can predict disease outcomes or comorbidities. This article is protected by copyright. All rights reserved. PMID: 30132823 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 22, 2018 Category: Dermatology Authors: McAleer MA, Jakasa I, Hurault G, Sarvari P, McLean WHI, Tanaka RJ, Kezic S, Irvine AD Tags: Br J Dermatol Source Type: research

Impact of Hidradenitis Suppurativa on Work Loss, Indirect Costs and Income.
Abstract BACKGROUND: Hidradenitis suppurativa (HS), a chronic cutaneous disease, can negatively affect work life. OBJECTIVE: This retrospective cohort study evaluates the indirect burden among employed HS patients in the US. METHODS: Newly diagnosed and general HS patients, employees (18-64 years) from a large claims database (1999Q1-2015Q1), were matched 1:5 to controls. Income growth and risk of leaving the workforce were assessed among the newly diagnosed HS/control cohorts in the 5-year study period; income, work loss days, and indirect costs (absenteeism and disability) were assessed among the gener...
Source: The British Journal of Dermatology - August 18, 2018 Category: Dermatology Authors: Tzellos T, Yang H, Mu F, Calimlim B, Signorovitch J Tags: Br J Dermatol Source Type: research

Long-term 52-week trends in apremilast safety outcomes for treatment of psoriasis in clinical practice: a multicentre, retrospective case series.
This article is protected by copyright. All rights reserved. PMID: 30120892 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 18, 2018 Category: Dermatology Authors: Ighani A, Georgakopoulos JR, Shear NH, Walsh S, Yeung J Tags: Br J Dermatol Source Type: research

Skin resident memory T cell population is not effectively constructed in systemic sclerosis.
This article is protected by copyright. All rights reserved. PMID: 30120898 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 18, 2018 Category: Dermatology Authors: Koguchi-Yoshioka H, Watanabe R, Fujisawa Y, Ishitsuka Y, Nakamura Y, Okiyama N, Fujimoto M Tags: Br J Dermatol Source Type: research

Autoantibody to transcriptional intermediary factor-1 β as myositis-specific antibody: clinical correlation with CADM or DM with mild myopathy.
CONCLUSION: Seven patients were confirmed to have anti-TIF-1β antibody without any other MSAs, including TIF-1α/γ antibodies, and six of them were diagnosed with DM. We suggest that anti-TIF-1β antibody is one of the MSAs, and that it is associated with clinically amyopathic DM or DM with mild myopathy. This article is protected by copyright. All rights reserved. PMID: 30120913 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 18, 2018 Category: Dermatology Authors: Ueda-Hayakawa I, Hamaguchi Y, Okiyama N, Motegi SI, Yamaoka T, Miyake S, Higashi A, Okamoto H, Takehara K, Fujimoto M Tags: Br J Dermatol Source Type: research

Efficacy and safety of daylight photodynamic therapy after tailored pretreatment with ablative fractional laser or microdermabrasion: a randomized, side-by-side, single-blind trial in patients with actinic keratosis and large area field cancerization.
Abstract BACKGROUND: Physical pretreatments can potentiate efficacy of daylight photodynamic therapy (dPDT), but clinical comparative studies remain limited. OBJECTIVES: Performed in large skin areas with actinic keratoses (AK) and photodamage, this blinded, randomized clinical trial compares efficacy and safety of dPDT after tailored skin pretreatment using ablative fractional laser (AFL) or microdermabrasion (MD). METHODS: Two ≥50 cm2 side-by-side areas were randomized to receive a single treatment with AFL-dPDT or MD-dPDT. Pretreatment parameters were tailored according to AK grade and skin constit...
Source: The British Journal of Dermatology - August 17, 2018 Category: Dermatology Authors: Wenande E, Phothong W, Bay C, Karmisholt KE, Haedersdal M, Togsverd-Bo K Tags: Br J Dermatol Source Type: research

Tumor spontaneous regression in an elderly patient with Squamous Cell Carcinoma of the cranial vertex pre-treated with cetuximab monotherapy.
This article is protected by copyright. All rights reserved. PMID: 30117145 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 17, 2018 Category: Dermatology Authors: Ginocchi L, Cirigliano G, Mazzatenta C, Baldini EE Tags: Br J Dermatol Source Type: research

Mosaic mutations in FGFR3 and FGFR2 are associated with naevoid acanthosis nigricans or RAVEN (round and velvety epidermal naevus).
This article is protected by copyright. All rights reserved. PMID: 30117157 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 17, 2018 Category: Dermatology Authors: Larsabal M, Cogrel O, Caumont C, Jegou MH, Taïeb A, Morice-Picard F Tags: Br J Dermatol Source Type: research

Hormonal, Stem Cell and Notch Signaling as Possible Mechanisms of Disease in Hidradenitis Suppurativa: a Systems-Level Transcriptomic Analysis.
This article is protected by copyright. All rights reserved. PMID: 30117141 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 16, 2018 Category: Dermatology Authors: Gauntner TD Tags: Br J Dermatol Source Type: research

Locally advanced skin cancers of the frail and elderly - consider adaptive split course radiotherapy (ASCRT).
This article is protected by copyright. All rights reserved. PMID: 30117147 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 16, 2018 Category: Dermatology Authors: Fogarty GB, McLaren KR, Moutrie Z, Poon TSC, Izard MA Tags: Br J Dermatol Source Type: research

Recurrent fungal infections in a Chinese patient with CARD9 deficiency and a review of 48 cases.
We reported a patient first suffered from Trichosporon Asahii (T. asahii) affecting skin, and then Candida albicans (C. albicans) infections involving digestive tract and joint, along with elevated serum IgE. After stimulation with C. albicans, PBMCs of this patient produced less TNF-a, IFN-γ and IL-17 than health controls. Furthermore, serum IgE levels of this patient were positively correlated with the severity of fungal infection during the course of treatment. Sanger sequencing identified one homozygous frameshift mutation (p.D274fsX60) in CARD9. We further performed a review including 48 cases with CARD9 deficie...
Source: The British Journal of Dermatology - August 16, 2018 Category: Dermatology Authors: Quan C, Li X, Shi RF, Zhao XQ, Xu H, Wang B, Wang XP, Hu WG, Hua C, Zheng J Tags: Br J Dermatol Source Type: research

The Extent of PXE Skin Changes is Related to Cardiovascular Complications and Visual Loss: a Cross-sectional Study.
This article is protected by copyright. All rights reserved. PMID: 30117153 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 16, 2018 Category: Dermatology Authors: Navasiolava N, Gnanou M, Douillard M, Saulnier P, Aranyi T, Ebran JM, Henni S, Humeau H, Lefthériotis G, Martin L Tags: Br J Dermatol Source Type: research

Associations between maternal socioeconomic position and psoriasis: A cohort study among the offspring of the Danish National Birth Cohort.
CONCLUSION: A steep social gradient in paediatric-onset psoriasis was observed. Maternal socioeconomic position may play a role in early life exposure to modifiable risk factors for psoriasis. Future studies may help elucidate which biological factors mediate the social gradient observed in our study. This article is protected by copyright. All rights reserved. PMID: 30117154 [PubMed - as supplied by publisher] (Source: The British Journal of Dermatology)
Source: The British Journal of Dermatology - August 16, 2018 Category: Dermatology Authors: Groot J, Nybo Andersen AM, Adam A, Tind Nielsen TE, Blegvad C, Skov L Tags: Br J Dermatol Source Type: research