Effect of radiation therapy on lymph node fluorescence in head and neck squamous cell carcinoma after intravenous injection of indocyanine green: a prospective evaluation
CONCLUSION: No differences were observed between the fluorescence of irradiated and non-irradiated lymph nodes, including invaded nodes. ICG-guided surgery can be performed after failed RT.TRIAL REGISTRATION: EudraCT ref. 2013-004498-29, registered 29 November 2013. https://www.clinicaltrialsregister.eu/ctr-search/search?query=2013-004498-29.PMID:38753288 | DOI:10.1186/s13550-024-01106-5 (Source: Cell Research)
Source: Cell Research - May 16, 2024 Category: Cytology Authors: Antoine Digonnet Sophie Vankerkhove Michel Moreau C écile Dekeyser Marie Quiriny Esther Willemse Nicolas de Saint Aubain Matteo Cappello Vincent Donckier Pierre Bourgeois Source Type: research
Bladder Cancer, Version 3.2024
J Natl Compr Canc Netw. 2024 May;22(4):216-225. doi: 10.6004/jnccn.2024.0024.ABSTRACTBladder cancer, the sixth most common cancer in the United States, is most commonly of the urothelial carcinoma histologic subtype. The clinical spectrum of bladder cancer is divided into 3 categories that differ in prognosis, management, and therapeutic aims: (1) non-muscle-invasive bladder cancer (NMIBC); (2) muscle invasive, nonmetastatic disease; and (3) metastatic bladder cancer. These NCCN Guidelines Insights detail recent updates to the NCCN Guidelines for Bladder Cancer, including changes in the fifth edition of the WHO Classificat...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - May 16, 2024 Category: Cancer & Oncology Authors: Thomas W Flaig Philippe E Spiess Michael Abern Neeraj Agarwal Rick Bangs Mark K Buyyounouski Kevin Chan Sam S Chang Paul Chang Terence Friedlander Richard E Greenberg Khurshid A Guru Harry W Herr Jean Hoffman-Censits Hristos Kaimakliotis Amar U Kishan Shi Source Type: research
Berberine increases the killing effect of pirarubicin on HCC cells by inhibiting ATG4B-autophagy pathway
Exp Cell Res. 2024 May 13:114094. doi: 10.1016/j.yexcr.2024.114094. Online ahead of print.ABSTRACTPirarubicin (THP) is a new generation of cell cycle non-specific anthracycline-based anticancer drug. In the clinic, THP and THP combination therapies have been shown to be effective in hepatocellular carcinoma (HCC) patients with transcatheter arterial chemoembolisation (TACE) without serious side effects. However, drug resistance limits its therapeutic efficacy. Berberine (BBR), an isoquinoline alkaloid, has been shown to possess antitumour properties against various malignancies. However, the synergistic effect of BBR and T...
Source: Experimental Cell Research - May 16, 2024 Category: Cytology Authors: Haiyan He Meng He Yunxia Wang Haojun Xiong Yu Xiong Meihua Shan Dong Liu Ziyuan Guo Yuhong Kou Yan Zhang Mingzhen Yang Jiqin Lian Liangbo Sun Fengtian He Source Type: research
Lactylome analyses suggest systematic lysine-lactylated substrates in oral squamous cell carcinoma under normoxia and hypoxia
Cell Signal. 2024 May 13:111228. doi: 10.1016/j.cellsig.2024.111228. Online ahead of print.ABSTRACTCancer cells tend to live in hypoxic environment characterized by enhanced glycolysis and accumulation of lactate. Intracellular lactate is shown to drive a novel type of post-translational modification (PTM), lysine lactylation (Kla). Kla has been confirmed to affect the malignant progression of tumors such as hepatocellular carcinoma (HCC) and colon cancer, whereas the global lactylomic profiling of oral squamous cell carcinoma (OSCC) is unclear. Here, the integrative lactylome and proteome analyses by using liquid chromato...
Source: Cellular Signalling - May 16, 2024 Category: Cytology Authors: Fan Song Chen Hou Yingzhao Huang Jianfeng Liang Hongshi Cai Guoli Tian Yaoqi Jiang Ziyi Wang Jinsong Hou Source Type: research
Tertiary Lymphoid Structures Gene Signature Predicts Prognosis and Immune Infiltration Analysis in Head and Neck Squamous Cell Carcinoma
CONCLUSION: High TLS signature is a promising independent prognostic factor for HNSCC patients. Immunological analysis indicated a correlation between TLS and immune cell infiltration in HNSCC. These findings provide a theoretical basis for future applications of TLS signature in HNSCC prognosis and immunotherapy.PMID:38751598 | PMC:PMC11092909 | DOI:10.2174/0113892029278082240118053857 (Source: Current Genomics)
Source: Current Genomics - May 16, 2024 Category: Genetics & Stem Cells Authors: Aiyan Xing Dongxiao Lv Changshun Wu Kai Zhou Tianhui Zhao Lihua Zhao Huaqing Wang Hong Feng Source Type: research
Expression Profiling of EMT Transcriptional Regulators ZEB1 and ZEB2 in Different Histopathological Grades of Oral Squamous Cell Carcinoma Patients
CONCLUSION: High expressions of ZEBs have been significantly associated with cancer progression and poor health. However, no association was found between OSCC with other clinicopathological features when compared to healthy controls.PMID:38751602 | PMC:PMC11092914 | DOI:10.2174/0113892029284920240212091903 (Source: Current Genomics)
Source: Current Genomics - May 16, 2024 Category: Genetics & Stem Cells Authors: Neha Baqai Rafat Amin Tehseen Fatima Zeba Ahmed Nousheen Faiz Source Type: research
Non-invasive biomarkers prognostic of decompensation events in NASH cirrhosis: a systematic literature review
J Mol Med (Berl). 2024 May 16. doi: 10.1007/s00109-024-02448-2. Online ahead of print.ABSTRACTLiver cirrhosis due to nonalcoholic steatohepatitis (NASH) is a life-threatening condition with increasing incidence world-wide. Although its symptoms are unspecific, it can lead to decompensation events such as ascites, hepatic encephalopathy, variceal hemorrhage, and hepatocellular carcinoma (HCC). In addition, an increased risk for cardiovascular events has been demonstrated in patients with NASH. Pharmacological treatments for NASH cirrhosis are not yet available, one of the reasons being the lack in surrogate endpoints availa...
Source: Molecular Medicine - May 16, 2024 Category: Molecular Biology Authors: Mattia Amoroso Salvador Augustin Sven Moosmang Isabella Gashaw Source Type: research
Prognostic value of CDKN2A in head and neck squamous cell carcinoma via pathomics and machine learning
This study aims to enhance the prognosis prediction of Head and Neck Squamous Cell Carcinoma (HNSCC) by employing artificial intelligence (AI) to analyse CDKN2A gene expression from pathology images, directly correlating with patient outcomes. Our approach introduces a novel AI-driven pathomics framework, delineating a more precise relationship between CDKN2A expression and survival rates compared to previous studies. Utilizing 475 HNSCC cases from the TCGA database, we stratified patients into high-risk and low-risk groups based on CDKN2A expression thresholds. Through pathomics analysis of 271 cases with available slides...
Source: Molecular Medicine - May 16, 2024 Category: Molecular Biology Authors: Yandan Wang Chaoqun Zhou Tian Li Junpeng Luo Source Type: research
CSE1L as a prognostic biomarker associated with pan cancer immune infiltration and drug sensitivity
CONCLUSION: Our findings demonstrate that CSE1L promotes tumor development in various malignancies, highlighting its potential as both a therapeutic target and prognostic indicator.PMID:38752776 | DOI:10.1080/1744666X.2024.2356747 (Source: Expert Review of Clinical Immunology)
Source: Expert Review of Clinical Immunology - May 16, 2024 Category: Allergy & Immunology Authors: Haiyang Li Lingwa Wang Zhaohui Ruan Xiaoyan Li Yifan Yang Jugao Fang Ru Wang Source Type: research
Prognostic value of CDKN2A in head and neck squamous cell carcinoma via pathomics and machine learning
This study aims to enhance the prognosis prediction of Head and Neck Squamous Cell Carcinoma (HNSCC) by employing artificial intelligence (AI) to analyse CDKN2A gene expression from pathology images, directly correlating with patient outcomes. Our approach introduces a novel AI-driven pathomics framework, delineating a more precise relationship between CDKN2A expression and survival rates compared to previous studies. Utilizing 475 HNSCC cases from the TCGA database, we stratified patients into high-risk and low-risk groups based on CDKN2A expression thresholds. Through pathomics analysis of 271 cases with available slides...
Source: J Cell Mol Med - May 16, 2024 Category: Molecular Biology Authors: Yandan Wang Chaoqun Zhou Tian Li Junpeng Luo Source Type: research
Organoruthenium metallocycle induced mutation in gld-1 tumor suppression gene in JK1466 strain and appreciable lifespan expansion
J Inorg Biochem. 2024 May 8;257:112593. doi: 10.1016/j.jinorgbio.2024.112593. Online ahead of print.ABSTRACTFour Ru(II) complexes (A2-A5) were synthesized from the reaction of coumarin Schiff base ligands (7da2-tsc, 7da3-mtsc, 7da4-etsc and 7da5-ptsc) with [RuHCl(CO)(PPh3)3]. The compounds were characterized by FT-IR, UV-Vis, 1H, 13C and 31P NMR, mass spectrometry and crystallographic analysis. Calf Thymus DNA (CT-DNA) binding studies revealed the intercalative mode of binding of the complexes with DNA. The results of Bovine serum albumin (BSA) binding studies established the interaction between BSA followed static quenchi...
Source: Journal of Inorganic Biochemistry - May 16, 2024 Category: Biochemistry Authors: S Nandhini M Ranjani G Thiruppathi Y M Jaithanya G Kalaiarasi M Ravi G Prabusankar J G Malecki P Sundararaj R Prabhakaran Source Type: research
Stimuli-sensitive Chitosan-based Nanosystems-immobilized Nucleic Acids for Gene Therapy in Breast Cancer and Hepatocellular Carcinoma
Curr Top Med Chem. 2024 May 14. doi: 10.2174/0115680266293173240506054439. Online ahead of print.ABSTRACTChitosan-based nanoparticles have emerged as a promising tool in the realm of cancer therapy, particularly for gene delivery. With cancer being a prevalent and devastating disease, finding effective treatment options is of utmost importance. These nanoparticles provide a unique solution by encapsulating specific genes and delivering them directly to cancer cells, offering immense potential for targeted therapy. The biocompatibility and biodegradability of chitosan, a naturally derived polymer, make it an ideal candidate...
Source: Current Topics in Medicinal Chemistry - May 16, 2024 Category: Chemistry Authors: Seyed Morteza Naghib Bahar Ahmadi M R Mozafari Source Type: research
Identifying and Validating an Angiogenesis-related Signature for the Prognosis of Head and Neck Squamous Cell Carcinoma
CONCLUSION: We constructed a reliable RiskScore model for the prognostic prediction of HNSCC patients, contributing to precise therapeutic intervention of the cancer.PMID:38752633 | DOI:10.2174/0109298673306245240514064119 (Source: Current Medicinal Chemistry)
Source: Current Medicinal Chemistry - May 16, 2024 Category: Chemistry Authors: Yueting Hou Haifeng Pang Xuemei Xu Dong Zhao Source Type: research
Dabrafenib Alleviates Hepatotoxicity Caused by Lenvatinib via Inhibiting the Death Receptor Signaling Pathway
In conclusion, our results validate that apoptosis caused by the death receptor signaling pathway is the key cause of lenvatinib-induced hepatotoxicity, and dabrafenib alleviates lenvatinib-induced hepatotoxicity by inhibiting this pathway.PMID:38754640 | DOI:10.1016/j.toxlet.2024.05.004 (Source: Toxicology Letters)
Source: Toxicology Letters - May 16, 2024 Category: Toxicology Authors: Xinyu Tao Mengting Cheng Xiangliang Huang Jiajia Chen Yunfang Zhou Ting Liu Xiaochun Zheng Nonger Shen Yiwen Zhang Peihua Luo Qiaojun He Hao Yan Ping Huang Source Type: research
Synthesis, characterization, and biological activity of cationic ruthenium-arene complexes with sulfur ligands
J Biol Inorg Chem. 2024 May 16. doi: 10.1007/s00775-024-02052-2. Online ahead of print.ABSTRACTFive cationic ruthenium-arene complexes with the generic formula [Ru(SAc)(S2C·NHC)(p-cymene)](PF6) (5a-e) were prepared in almost quantitative yields using a straightforward one-pot, two-step experimental procedure starting from [RuCl2(p-cymene)]2, an imidazol(in)ium-2-dithiocarboxylate (NHC·CS2) zwitterion, KSAc, and KPF6. These half-sandwich compounds were fully characterized by various analytical techniques and the molecular structures of two of them were solved by X-ray diffraction analysis, which revealed the existence of ...
Source: Journal of Biological Inorganic Chemistry : JBIC - May 16, 2024 Category: Chemistry Authors: Mohammed Zain Aldin Guillermo Zaragoza Eva Choquenet Guillaume Blampain Gilles Berger Lionel Delaude Source Type: research
