TIN2-mediated reduction of mitophagy induces RPE senescence under high glucose
Cell Signal. 2024 Apr 22:111188. doi: 10.1016/j.cellsig.2024.111188. Online ahead of print.ABSTRACTThe telomere-associated protein TIN2 localizes to both telomeres and mitochondria. Nevertheless, the impact of TIN2 on retinal pigment epithelial (RPE) cells in diabetic retinopathy (DR) remains unclear. This research aims to examine the role of TIN2 in the senescence of RPE and its potential as a therapeutic target. Western blotting and immunofluorescence staining were utilized to identify TIN2 expression and mitophagy. RT-qPCR was employed to identify senescent associated secretory phenotype (SASP) in ARPE-19 cells infected...
Source: Cellular Signalling - April 24, 2024 Category: Cytology Authors: Shuchang Zhang Shimei Chen Dandan Sun Shenping Li Jun Sun Qing Gu Peiyu Liu Xiaoqian Wang Hong Zhu Xun Xu Huiming Li Fang Wei Source Type: research
High-altitude hypoxia promotes BRD4-mediated activation of the Wnt/ β-catenin pathway and disruption of intestinal barrier
Cell Signal. 2024 Apr 20:111187. doi: 10.1016/j.cellsig.2024.111187. Online ahead of print.ABSTRACTHypobaric hypoxia, commonly experienced at elevated altitudes, presents significant physiological challenges. Our investigation is centered on the impact of the bromodomain protein 4 (BRD4) under these conditions, especially its interaction with the Wnt/β-Catenin pathway and resultant effects on glycolytic inflammation and intestinal barrier stability. By combining transcriptome sequencing with bioinformatics, we identified BRD4's key role in hypoxia-related intestinal anomalies. Clinical parameters of altitude sickness pati...
Source: Cellular Signalling - April 22, 2024 Category: Cytology Authors: Yun-Han Yang Fang Yan Wenqiang Yuan Peng-Shuang Shi Shi-Min Wu De-Jun Cui Source Type: research
High-altitude hypoxia promotes BRD4-mediated activation of the Wnt/ β-catenin pathway and disruption of intestinal barrier
Cell Signal. 2024 Apr 20:111187. doi: 10.1016/j.cellsig.2024.111187. Online ahead of print.ABSTRACTHypobaric hypoxia, commonly experienced at elevated altitudes, presents significant physiological challenges. Our investigation is centered on the impact of the bromodomain protein 4 (BRD4) under these conditions, especially its interaction with the Wnt/β-Catenin pathway and resultant effects on glycolytic inflammation and intestinal barrier stability. By combining transcriptome sequencing with bioinformatics, we identified BRD4's key role in hypoxia-related intestinal anomalies. Clinical parameters of altitude sickness pati...
Source: Cellular Signalling - April 22, 2024 Category: Cytology Authors: Yun-Han Yang Fang Yan Wenqiang Yuan Peng-Shuang Shi Shi-Min Wu De-Jun Cui Source Type: research
Inhibition of YAP/TAZ pathway contributes to the cytotoxicity of silibinin in MCF-7 and MDA-MB-231 human breast cancer cells
Cell Signal. 2024 Apr 19:111186. doi: 10.1016/j.cellsig.2024.111186. Online ahead of print.ABSTRACTBreast cancer is one of the most common cancers threatening women's health. Our previous study found that silibinin induced the death of MCF-7 and MDA-MB-231 human breast cancer cells. We noticed that silibinin-induced cell damage was accompanied by morphological changes, including the increased cell aspect ratio (cell length/width) and decreased cell area. Besides, the cytoskeleton is also destroyed in cells treated with silibinin. YAP/TAZ, a mechanical signal sensor interacted with extracellular pressure, cell adhesion area...
Source: Cellular Signalling - April 21, 2024 Category: Cytology Authors: Jianing Fu Weiwei Liu Siyu Liu Ruxiao Zhao Toshihiko Hayashi Haina Zhao Yinlanqi Xiang Kazunori Mizuno Shunji Hattori Hitomi Fujisaki Takashi Ikejima Source Type: research
Moringin, an isothiocyanate modulates multiple cellular signalling molecules in breast cancer cells
Cell Signal. 2024 Apr 19:111181. doi: 10.1016/j.cellsig.2024.111181. Online ahead of print.ABSTRACTProhibitin (PHB) is a pleiotropic molecule with a variety of known functions and subcellular locations. PHB's function in breast cancer is poorly understood. Herein, we report that PHB is expressed in cancer types of diverse origin including breast cancer. The cancer patients with changes in PHB were reported to have significantly reduced 'overall survival' in comparison to the cases without alterations in PHB. The expression of PHB was increased by H2O2 and also by Moringin (MG), which is an isothiocyanate derived from the s...
Source: Cellular Signalling - April 21, 2024 Category: Cytology Authors: Ankit Srivastava Shruti Mishra None Avadhesh Anusmita Shekher Vipin Rai Anupam Dhasmana Jayanta Das Daniele Perenzoni Renato Iori Subash C Gupta Source Type: research
Identification and validation of cuproptosis and disulfidptosis related genes in colorectal cancer
This study offers novel insights into the interplay between cuproptosis and disulfidptosis. The application of the prognostic model holds promise for more effectively predicting the overall survival of colorectal cancer patients.PMID:38643947 | DOI:10.1016/j.cellsig.2024.111185 (Source: Cellular Signalling)
Source: Cellular Signalling - April 21, 2024 Category: Cytology Authors: Xiaoqing Gong Qixian Wu Zhenlin Tan Shumao Lin Jingdong Zhou Shihao Lin Weilin Wang Zhoujian Han Tingting Xie Jiyuan Zhou Source Type: research
CXXC5 drove inflammation and ovarian cancer proliferation via transcriptional activation of ZNF143 and EGR1
Cell Signal. 2024 Apr 19;119:111180. doi: 10.1016/j.cellsig.2024.111180. Online ahead of print.ABSTRACTCXXC5, a zinc-finger protein, is known for its role in epigenetic regulation via binding to unmethylated CpG islands in gene promoters. As a transcription factor and epigenetic regulator, CXXC5 modulates various signaling processes and acts as a key coordinator. Altered expression or activity of CXXC5 has been linked to various pathological conditions, including tumorigenesis. Despite its known role in cancer, CXXC5's function and mechanism in ovarian cancer are unclear. We analyzed multiple public databases and found tha...
Source: Cellular Signalling - April 20, 2024 Category: Cytology Authors: Ting Geng Qigang Sun Jingliang He Yulu Chen Wenhao Cheng Jing Shen Bin Liu Meiqi Zhang Sen Wang Kadirya Asan Mengwei Song Qi Gao Yizhuo Song Ruotong Liu Xing Liu Yuanyuan Ding Aixin Jing Xiaoqing Ye Hongyu Ren Kaile Zeng Ying Zhou Boyu Zhang Shaojie Ma We Source Type: research
S100P facilitates LUAD progression via PKA/c-Jun-mediated tumor-associated macrophage recruitment and polarization
In conclusion, our study demonstrates that S100P facilitates LUAD cells growth by recruiting M2 TAMs through PKA/c-Jun signaling, resulting in the production of various cytokines. Considering these findings, S100P holds promise as an important diagnostic marker and potential therapeutic target for LUAD.PMID:38640980 | DOI:10.1016/j.cellsig.2024.111179 (Source: Cellular Signalling)
Source: Cellular Signalling - April 19, 2024 Category: Cytology Authors: Lu Gao Ying Bai Jiawei Zhou Chao Liang Yunjia Dong Tao Han Yafeng Liu Jianqiang Guo Jing Wu Dong Hu Source Type: research
STAT1 mediated downregulation of the tumor suppressor gene PDCD4, is driven by the atypical cadherin FAT1, in glioblastoma
This study therefore identifies STAT1 as a novel downstream mediator of FAT1, promoting pro-tumorigenic activity in GBM, by suppressing PDCD4 expression.PMID:38640981 | DOI:10.1016/j.cellsig.2024.111178 (Source: Cellular Signalling)
Source: Cellular Signalling - April 19, 2024 Category: Cytology Authors: Tipu Khan Mariyam Almas Nargis Malik Akansha Jalota Shaifali Sharma Sk Asif Ali Kalpana Luthra Vaishali Suri Ashish Suri Soumen Basak Pankaj Seth Kunzang Chosdol Subrata Sinha Source Type: research
PFKFB3 regulates breast cancer tumorigenesis and Fulvestrant sensitivity by affecting ER α stability
In conclusion, these data suggest that PFKFB3 is identified as an adverse prognosis factor for ER-positive breast cancer and plays a previously unrecognized role in the regulation of ERα stability and activity. Our results further explores an effective approach to improve fulvestrant sensitivity through the early combination with a PFKFB3 inhibitor.PMID:38640982 | DOI:10.1016/j.cellsig.2024.111184 (Source: Cellular Signalling)
Source: Cellular Signalling - April 19, 2024 Category: Cytology Authors: Wenzhi Jia Qianyun Wu Mengqin Shen Xiaofeng Yu Shuxian An Li Zhao Gang Huang Jianjun Liu Source Type: research
Exosomal miRNA-92a derived from cancer-associated fibroblasts promote invasion and metastasis in breast cancer by regulating G3BP2
In this study, we identified CAF-derived exosomes that transport functional miR-92a from CAFs to tumor cells, thereby intensifying the aggressiveness of breast cancer. CAFs downregulate the expression of G3BP2 in breast cancer cells, and a significant elevation in miR-92a levels in CAF-derived exosomes was observed. Both in vitro and in vivo experiments demonstrate that miR-92a enhances breast cancer cell migration and invasion by directly targeting G3BP2, functioning as a tumor-promoting miRNA. We validated that the RNA-binding proteins SNRPA facilitate the transfer of CAF-derived exosomal miR-92a to breast cancer cells. ...
Source: Cellular Signalling - April 19, 2024 Category: Cytology Authors: Zhimei Sheng Xuejie Wang Xiaodi Ding Yuanhang Zheng Ai Guo Jiayu Cui Jing Ma Wanli Duan Hao Dong Hongxing Zhang Meimei Cui Wenxia Su Baogang Zhang Source Type: research
Current knowledge of ferroptosis in the pathogenesis and prognosis of oral squamous cell carcinoma
In this study, we performed a first attempt to collect the current evidence on the proposed roles of ferroptosis in OSCC through a comprehensive review. Based on clinical data from the relevant studies within this topic, we found that ferroptosis-associated tumor microenvironment, ferroptosis-related genes (FRGs), and ferroptosis-related lncRNAs exhibited a potent prognostic value for OSCC patients. Mechanistically, experimental data revealed that the proliferation and tumorigenesis of OSCC might be associated with the inhibition of cellular ferroptosis through the activation of glutathione peroxidase 4 (GPX4) and adipocyt...
Source: Cellular Signalling - April 18, 2024 Category: Cytology Authors: Liyuan Zhou Youjun Wu Yukang Ying Yan Ding Source Type: research
Hepatitis B virus X protein promotes tumor glycolysis by downregulating lncRNA OIP5-AS1/HKDC1 in HCC
This study aims to investigate the role of HBV in HCC pathogenesis involving glucose metabolism. Long non-coding RNA (lncRNA) OIP5-AS1 was significantly downregulated in HBV-positive HCC patients, and its low expression indicated a poor prognosis. This lncRNA was primarily localized in the cytoplasm, acting as a tumor suppressor. HBV protein X (HBx) repressed OIP5-AS1 expression by inhibiting a ligand-activated transcriptional factor peroxisome proliferator-activated receptor α (PPARα). Furthermore, mechanistic studies revealed that OIP5-AS1 inhibited tumor growth by suppressing Hexokinase domain component 1 (HKDC1)-medi...
Source: Cellular Signalling - April 18, 2024 Category: Cytology Authors: Fan Shi Jingjing Jiang Baohua Wang Liang Hong Yongting Zhang Yuting Meng Xujun Zhang Lan Gong Jianjun Lin Hongyan Diao Source Type: research
Current knowledge of ferroptosis in the pathogenesis and prognosis of oral squamous cell carcinoma
In this study, we performed a first attempt to collect the current evidence on the proposed roles of ferroptosis in OSCC through a comprehensive review. Based on clinical data from the relevant studies within this topic, we found that ferroptosis-associated tumor microenvironment, ferroptosis-related genes (FRGs), and ferroptosis-related lncRNAs exhibited a potent prognostic value for OSCC patients. Mechanistically, experimental data revealed that the proliferation and tumorigenesis of OSCC might be associated with the inhibition of cellular ferroptosis through the activation of glutathione peroxidase 4 (GPX4) and adipocyt...
Source: Cellular Signalling - April 18, 2024 Category: Cytology Authors: Liyuan Zhou Youjun Wu Yukang Ying Yan Ding Source Type: research
Hepatitis B virus X protein promotes tumor glycolysis by downregulating lncRNA OIP5-AS1/HKDC1 in HCC
This study aims to investigate the role of HBV in HCC pathogenesis involving glucose metabolism. Long non-coding RNA (lncRNA) OIP5-AS1 was significantly downregulated in HBV-positive HCC patients, and its low expression indicated a poor prognosis. This lncRNA was primarily localized in the cytoplasm, acting as a tumor suppressor. HBV protein X (HBx) repressed OIP5-AS1 expression by inhibiting a ligand-activated transcriptional factor peroxisome proliferator-activated receptor α (PPARα). Furthermore, mechanistic studies revealed that OIP5-AS1 inhibited tumor growth by suppressing Hexokinase domain component 1 (HKDC1)-medi...
Source: Cellular Signalling - April 18, 2024 Category: Cytology Authors: Fan Shi Jingjing Jiang Baohua Wang Liang Hong Yongting Zhang Yuting Meng Xujun Zhang Lan Gong Jianjun Lin Hongyan Diao Source Type: research
