Circ_0007534 promotes cholangiocarcinoma stemness and resistance to anoikis through DDX3X-mediated positive feedback regulation of parental gene DDX42
In conclusion, this study sheds light on the pivotal role and molecular mechanism of circ_0007534 in the development of CCA, offering potential new targets for early diagnosis and treatment.PMID:38492624 | DOI:10.1016/j.cellsig.2024.111141 (Source: Cellular Signalling)
Source: Cellular Signalling - March 16, 2024 Category: Cytology Authors: Sidi Liu Canghai Guan Xiangjun Sha Xin Gao Xinlei Zou Chengru Yang Xinmiao Zhang Xiangyu Zhong Xingming Jiang Source Type: research

Exploration of gut microbiome and inflammation: A review on key signalling pathways
Cell Signal. 2024 Mar 14:111140. doi: 10.1016/j.cellsig.2024.111140. Online ahead of print.ABSTRACTThe gut microbiome, a crucial component of the human system, is a diverse collection of microbes that belong to the gut of human beings as well as other animals. These microbial communities continue to coexist harmoniously with their host organisms and perform various functions that affect the host's general health. Each person's gut microbiota has a unique makeup. The gut microbiota is well acknowledged to have a part in the local as well as systemic inflammation that underlies a number of inflammatory disorders (e.g., ather...
Source: Cellular Signalling - March 16, 2024 Category: Cytology Authors: Manisha Nigam Kanchan Devi Henrique D M Coutinho Abhay Prakash Mishra Source Type: research

Deciphering alternative splicing events and their therapeutic implications in colorectal Cancer
This study analyzed AS Percent Spliced In (PSI) values from 49 pairs of CRC and normal samples in the TCGA SpliceSeq database. Using Lasso and SVM, AS features that can differentiate colorectal cancer from normal were screened. Univariate COX regression analysis identified prognosis-related AS events. A risk model was constructed and validated using machine learning, Kaplan-Meier analysis, and Decision Curve Analysis. The regulatory effect of protein arginine methyltransferase 5 (PRMT5) on poly(RC) binding protein 1 (PCBP1) was verified by immunoprecipitation experiments, and the effect of PCBP1 on the AS of Obscurin (OBSC...
Source: Cellular Signalling - March 14, 2024 Category: Cytology Authors: Wenbo Ding Qianni Xiao Yanzhe Yue Shuyu Chen Xiangjian She Bei Pan Linpeng Zhou Yujuan Yin Youyue Li Shukui Wang Mu Xu Source Type: research

Deciphering alternative splicing events and their therapeutic implications in colorectal Cancer
This study analyzed AS Percent Spliced In (PSI) values from 49 pairs of CRC and normal samples in the TCGA SpliceSeq database. Using Lasso and SVM, AS features that can differentiate colorectal cancer from normal were screened. Univariate COX regression analysis identified prognosis-related AS events. A risk model was constructed and validated using machine learning, Kaplan-Meier analysis, and Decision Curve Analysis. The regulatory effect of protein arginine methyltransferase 5 (PRMT5) on poly(RC) binding protein 1 (PCBP1) was verified by immunoprecipitation experiments, and the effect of PCBP1 on the AS of Obscurin (OBSC...
Source: Cellular Signalling - March 14, 2024 Category: Cytology Authors: Wenbo Ding Qianni Xiao Yanzhe Yue Shuyu Chen Xiangjian She Bei Pan Linpeng Zhou Yujuan Yin Youyue Li Shukui Wang Mu Xu Source Type: research

COMP promotes pancreatic fibrosis by activating pancreatic stellate cells through CD36-ERK/AKT signaling pathways
CONCLUSION: In conclusion, this study showed that COMP was up-regulated in CP fibrotic tissues and COMP induced the activation, proliferation and migration of PSCs through the CD36-ERK/AKT signaling pathway. COMP may be a potential therapeutic candidate for the treatment of CP. Interfering with the expression of COMP or the communication between COMP and CD36 on PSCs may be the next direction for therapeutic research.PMID:38479555 | DOI:10.1016/j.cellsig.2024.111135 (Source: Cellular Signalling)
Source: Cellular Signalling - March 13, 2024 Category: Cytology Authors: Yi Wang Hai-Tao Li Gang Liu Chuan-Shen Jiang Yan-Hong Ni Jing-Hui Zeng Xia Lin Qing-Yun Wang Da-Zhou Li Wen Wang Xiang-Peng Zeng Source Type: research

Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study
In conclusion, the low level of m6A methylation modification may contribute to the low expression of EBF3 during PD. Additionally, EBF3 attenuates PD by activating CNTNAP4 transcription, suggesting that EBF3 may be a novel therapeutic target in PD.PMID:38479556 | DOI:10.1016/j.cellsig.2024.111139 (Source: Cellular Signalling)
Source: Cellular Signalling - March 13, 2024 Category: Cytology Authors: Wentao Hu Menghan Wang Guifang Sun Limin Zhang Hong Lu Source Type: research

COMP promotes pancreatic fibrosis by activating pancreatic stellate cells through CD36-ERK/AKT signaling pathways
CONCLUSION: In conclusion, this study showed that COMP was up-regulated in CP fibrotic tissues and COMP induced the activation, proliferation and migration of PSCs through the CD36-ERK/AKT signaling pathway. COMP may be a potential therapeutic candidate for the treatment of CP. Interfering with the expression of COMP or the communication between COMP and CD36 on PSCs may be the next direction for therapeutic research.PMID:38479555 | DOI:10.1016/j.cellsig.2024.111135 (Source: Cellular Signalling)
Source: Cellular Signalling - March 13, 2024 Category: Cytology Authors: Yi Wang Hai-Tao Li Gang Liu Chuan-Shen Jiang Yan-Hong Ni Jing-Hui Zeng Xia Lin Qing-Yun Wang Da-Zhou Li Wen Wang Xiang-Peng Zeng Source Type: research

Early B Cell Factor 3 (EBF3) attenuates Parkinson's disease through directly regulating contactin-associated protein-like 4 (CNTNAP4) transcription: An experimental study
In conclusion, the low level of m6A methylation modification may contribute to the low expression of EBF3 during PD. Additionally, EBF3 attenuates PD by activating CNTNAP4 transcription, suggesting that EBF3 may be a novel therapeutic target in PD.PMID:38479556 | DOI:10.1016/j.cellsig.2024.111139 (Source: Cellular Signalling)
Source: Cellular Signalling - March 13, 2024 Category: Cytology Authors: Wentao Hu Menghan Wang Guifang Sun Limin Zhang Hong Lu Source Type: research

microRNA-125b-1-3p mediates autophagy via the RRAGD/mTOR/ULK1 signaling pathway and mitigates atherosclerosis progression
Cell Signal. 2024 Mar 10:111136. doi: 10.1016/j.cellsig.2024.111136. Online ahead of print.ABSTRACTAtherosclerosis is characterised by lipid accumulation and formation of foam cells in arterial walls. Dysregulated autophagy is a crucial factor in atherosclerosis development. The significance of microRNA (miR)-125b-1-3p in cardiovascular disease is well-established; however, its precise role in regulating autophagy and impact on atherosclerosis in vascular smooth muscle cells (VSMCs) remain unclear. Here, we observed reduced autophagic activity and decreased miR-125b expression during atherosclerosis progression. miR-125b-1...
Source: Cellular Signalling - March 12, 2024 Category: Cytology Authors: Xin Chen Yanhong Cao Yining Guo Jing Liu Xiaohan Ye Huan Li Lu Zhang Wenwei Feng Shaoxiang Xian Zhongqi Yang Lingjun Wang Ting Wang Source Type: research

microRNA-125b-1-3p mediates autophagy via the RRAGD/mTOR/ULK1 signaling pathway and mitigates atherosclerosis progression
Cell Signal. 2024 Mar 10:111136. doi: 10.1016/j.cellsig.2024.111136. Online ahead of print.ABSTRACTAtherosclerosis is characterised by lipid accumulation and formation of foam cells in arterial walls. Dysregulated autophagy is a crucial factor in atherosclerosis development. The significance of microRNA (miR)-125b-1-3p in cardiovascular disease is well-established; however, its precise role in regulating autophagy and impact on atherosclerosis in vascular smooth muscle cells (VSMCs) remain unclear. Here, we observed reduced autophagic activity and decreased miR-125b expression during atherosclerosis progression. miR-125b-1...
Source: Cellular Signalling - March 12, 2024 Category: Cytology Authors: Xin Chen Yanhong Cao Yining Guo Jing Liu Xiaohan Ye Huan Li Lu Zhang Wenwei Feng Shaoxiang Xian Zhongqi Yang Lingjun Wang Ting Wang Source Type: research

Glucose regulates the HMGB1 signaling pathway through SIRT1 in glioma
CONCLUSION: Glucose has the ability to regulate the HMGB1 associated signaling pathway through SIRT1, thus promoting glioma progression. This holds significant research value.PMID:38467242 | DOI:10.1016/j.cellsig.2024.111137 (Source: Cellular Signalling)
Source: Cellular Signalling - March 11, 2024 Category: Cytology Authors: Yu Wang Shuai Wang Yuhao Wang Chengcheng Wang Yuhang Tang Chao Zhang Shiqiang Hou Dong Yu Ning Lin Source Type: research

The polybasic region in G αi proteins: Relevant or not? Insights from Gαi < sub > 3 < /sub > research
Cell Signal. 2024 Mar 9:111138. doi: 10.1016/j.cellsig.2024.111138. Online ahead of print.ABSTRACTHeterotrimeric G proteins are responsible for signal transduction from G-protein-coupled receptors (GPCRs) to intracellular effectors. This process is only possible when G proteins are located on the inner side of the cell membrane due to the specific localization of GPCR receptors. The Gα subunit is directed to the cell membrane through several signals, including modification by fatty acid moieties, interaction with the Gβγ complex, and, as observed in some Gα proteins, the presence of basic amino acid residues in the N-t...
Source: Cellular Signalling - March 11, 2024 Category: Cytology Authors: Beata Rysiewicz Ewa B łasiak Marta Dziedzicka-Wasylewska Agnieszka Polit Source Type: research

HK2 promotes migration and invasion of intrahepatic cholangiocarcinoma via enhancing cancer stem-like cells' resistance to anoikis
Cell Signal. 2024 Mar 5;118:111126. doi: 10.1016/j.cellsig.2024.111126. Online ahead of print.ABSTRACTCancer stem-like cells (CSLCs) and anoikis resistance play crucial roles in the metastasis of cancers. However, it remains unclear whether CSLCs are related to anoikis resistance in intrahepatic cholangiocarcinoma (ICC). Here we identified a group of stemness-related anoikis genes (SRAGs) via bioinformatic analysis of public data. Accordingly, a novel anoikis-related classification was established and it divided ICC into C1 and C2 type. Different type ICC displayed distinct prognosis, molecular as well immune characteristi...
Source: Cellular Signalling - March 7, 2024 Category: Cytology Authors: Xiaojing Du Zhuoran Qi Yunjia Jiao Wenzhi Wu Qingke Huang Xuecheng Sun Sunkuan Hu Source Type: research

HK2 promotes migration and invasion of intrahepatic cholangiocarcinoma via enhancing cancer stem-like cells' resistance to anoikis
Cell Signal. 2024 Mar 5;118:111126. doi: 10.1016/j.cellsig.2024.111126. Online ahead of print.ABSTRACTCancer stem-like cells (CSLCs) and anoikis resistance play crucial roles in the metastasis of cancers. However, it remains unclear whether CSLCs are related to anoikis resistance in intrahepatic cholangiocarcinoma (ICC). Here we identified a group of stemness-related anoikis genes (SRAGs) via bioinformatic analysis of public data. Accordingly, a novel anoikis-related classification was established and it divided ICC into C1 and C2 type. Different type ICC displayed distinct prognosis, molecular as well immune characteristi...
Source: Cellular Signalling - March 7, 2024 Category: Cytology Authors: Xiaojing Du Zhuoran Qi Yunjia Jiao Wenzhi Wu Qingke Huang Xuecheng Sun Sunkuan Hu Source Type: research

HK2 promotes migration and invasion of intrahepatic cholangiocarcinoma via enhancing cancer stem-like cells' resistance to anoikis
Cell Signal. 2024 Mar 5;118:111126. doi: 10.1016/j.cellsig.2024.111126. Online ahead of print.ABSTRACTCancer stem-like cells (CSLCs) and anoikis resistance play crucial roles in the metastasis of cancers. However, it remains unclear whether CSLCs are related to anoikis resistance in intrahepatic cholangiocarcinoma (ICC). Here we identified a group of stemness-related anoikis genes (SRAGs) via bioinformatic analysis of public data. Accordingly, a novel anoikis-related classification was established and it divided ICC into C1 and C2 type. Different type ICC displayed distinct prognosis, molecular as well immune characteristi...
Source: Cellular Signalling - March 7, 2024 Category: Cytology Authors: Xiaojing Du Zhuoran Qi Yunjia Jiao Wenzhi Wu Qingke Huang Xuecheng Sun Sunkuan Hu Source Type: research