ALDH1A3 contributes to tumorigenesis in high-grade serous ovarian cancer by epigenetic modification
Cell Signal. 2024 Jan 9;116:111044. doi: 10.1016/j.cellsig.2024.111044. Online ahead of print.ABSTRACTHigh-grade serous ovarian cancer (HGSOC) is the most lethal histotype of ovarian cancer due to its unspecific symptoms in part. ALDH1A3 (aldehyde dehydrogenase 1 family member A3) is a key enzyme for acetyl-CoA production involving aggressive behaviors of cancers. However, ALDH1A3's effects and molecular mechanisms in HGSOC remain to be clarified. Using RNA-seq and publicly available datasets, ALDH1A3 was found to be highly expressed in HGSOC, and associated with poor survival. Knockdown of ALDH1A3 prevented HGSOC tumorige...
Source: Cellular Signalling - January 11, 2024 Category: Cytology Authors: Jiazhen Huang Ying Tang Yibing Li Wei Wei Fuli Kang Shuang Tan Lin Lin Xiaohang Lu Heng Wei Ning Wang Source Type: research
HMGB1-mediated transcriptional activation of circadian gene TIMELESS contributes to endometrial cancer progression through Wnt- β-catenin pathway
Cell Signal. 2024 Jan 10;116:111045. doi: 10.1016/j.cellsig.2024.111045. Online ahead of print.ABSTRACTTIMELESS (TIM) is a circadian gene which is implicated in the regulation of daily rhythm, DNA replication and repair, and cancer initiation and progression. Nevertheless, the role of TIM in endometrial cancer (EC) development is largely unknown. Bioinformatics analysis showed that TIM was aberrantly up-regulated in EC tissues and positively correlated with clinical or histological grade of EC. Functional studies showed that TIM knockdown reduced EC cell viability and restrained EC cell migration in vitro, as well as block...
Source: Cellular Signalling - January 11, 2024 Category: Cytology Authors: Zhaoxia Wang Simin He Liqing Xin Ying Zhou Le Zhao Fuyuan Wang Source Type: research
MBIP promotes ESCC metastasis by activating MAPK pathway
Cell Signal. 2024 Mar;115:111040. doi: 10.1016/j.cellsig.2024.111040. Epub 2024 Jan 8.ABSTRACTMBIP is a component of the Ada2A containing complex (ATAC) and has been identified as a susceptibility gene in several cancers. However, the role and molecular mechanism of MBIP in esophageal squamous cell carcinoma (ESCC) remain unclear. Our finding indicated that the expression level of MBIP in ESCC was higher than that in normal tissue (P < 0.05) based on the data from the Cancer Gene Atlas (TCGA) and Gene Expression Omnibus (GEO). Kaplan-Meier analysis showed that high MBIP expression was closely associated with deeper inva...
Source: Cellular Signalling - January 10, 2024 Category: Cytology Authors: Yanchun Ma Yuyan Hua XiaoJie Yin Ye Jiao Enwei Xu Ting Yan Jian Yang Ling Zhang Source Type: research
Aldehyde oxidase 1 promotes gallbladder carcinogenesis through ROS-mediated activation of the Wnt/ β-catenin pathway
CONCLUSIONS: The study indicates that AOX1 functions as a carcinogenic factor in gallbladder carcinoma, enhancing cell proliferation, migration, invasion, and the EMT. These effects are driven by the activation of the Wnt/β-catenin pathway mediated by reactive oxygen species (ROS). Therefore,AOX1 presents potential as a valuable prognostic and diagnostic marker as well as a target for therapeutic intervention in the gallbladder cancer.PMID:38199597 | DOI:10.1016/j.cellsig.2024.111042 (Source: Cellular Signalling)
Source: Cellular Signalling - January 10, 2024 Category: Cytology Authors: Ziheng Yuan Genfa Yi Run Ma Zhuo Wang Jihong Hu Wei Zhao Ying Hu Source Type: research
Prolyl isomerase Pin1 sculpts the immune microenvironment of colorectal cancer
In this study, we detected the effect of Pin1 on immune cells and immune checkpoint PD-L1 in the TME of CRC and explored the anti-tumor efficacy of Pin1 inhibitor ATRA combined with PD-1 antibody. We found that Pin1 facilitated the immunosuppressive TME by raising the proportion of myeloid-derived suppressor cells (MDSCs) and declining the percentage of CD8+ T cells and CD4+ T cells. Pin1 restrained PD-L1 protein expression in CRC cells and the effect was tempered by endoplasmic reticulum (ER) stress inducers. Mechanically, Pin1 overexpression decreased the stability of PD-L1 and promoted its degradation by mitigating ER s...
Source: Cellular Signalling - January 10, 2024 Category: Cytology Authors: Yang Li Zhongnan Yuan Linlin Wang Jing Yang Pei Pu Yunting Le XianWei Chen Chongyang Wang Yating Gao Yi Liu Jialin Wang Xu Gao Yanze Li Hefei Wang Chaoxia Zou Source Type: research
LAIR1-mediated resistance of hepatocellular carcinoma cells to T cells through a GSK-3 β/β-catenin/MYC/PD-L1 pathway
CONCLUSION: LAIR1 increased PD-L1 expression through the GSK-3β/β-catenin/MYC/PD-L1 pathway and promoted immune evasion of HCC cells. Targeted inhibition of LAIR1 helped to enhance the immune killing effect of CD8+ T cells in HCC.PMID:38199599 | DOI:10.1016/j.cellsig.2024.111039 (Source: Cellular Signalling)
Source: Cellular Signalling - January 10, 2024 Category: Cytology Authors: Banglun Pan Xiaoling Ke Jiacheng Qiu Dongjie Ye Zhu Zhang Xiaoxia Zhang Yue Luo Yuxin Yao Xiaoxuan Wu Xiaoqian Wang Nanhong Tang Source Type: research
METTL3-mediated m < sup > 6 < /sup > A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition
In conclusion, our research demonstrates that METTL3-mediated m6A modification of SOX4 plays a crucial role in regulating osteoblast proliferation and differentiation through its recognition by YTHDF3. Our research confirms METTL3-m6A-SOX4-YTHDF3 as an essential axis and potential mechanism in OP.PMID:38195035 | DOI:10.1016/j.cellsig.2024.111038 (Source: Cellular Signalling)
Source: Cellular Signalling - January 9, 2024 Category: Cytology Authors: Zhi-Wei Feng Bo Peng Sheng-Hong Wang Da-Cheng Zhao Yao-Bin Wang Ao Yang Hong-Wei Zhan Xiao-Yun Sheng Li-Hu Xu Xiao-Jun Ren Fei Yang Bin Geng Ya-Yi Xia Source Type: research
METTL3-mediated m < sup > 6 < /sup > A modification of SOX4 regulates osteoblast proliferation and differentiation via YTHDF3 recognition
In conclusion, our research demonstrates that METTL3-mediated m6A modification of SOX4 plays a crucial role in regulating osteoblast proliferation and differentiation through its recognition by YTHDF3. Our research confirms METTL3-m6A-SOX4-YTHDF3 as an essential axis and potential mechanism in OP.PMID:38195035 | DOI:10.1016/j.cellsig.2024.111038 (Source: Cellular Signalling)
Source: Cellular Signalling - January 9, 2024 Category: Cytology Authors: Zhi-Wei Feng Bo Peng Sheng-Hong Wang Da-Cheng Zhao Yao-Bin Wang Ao Yang Hong-Wei Zhan Xiao-Yun Sheng Li-Hu Xu Xiao-Jun Ren Fei Yang Bin Geng Ya-Yi Xia Source Type: research
An integrative pan-cancer analysis of WWC family genes and functional validation in lung cancer
Cell Signal. 2024 Jan 6:111034. doi: 10.1016/j.cellsig.2024.111034. Online ahead of print.ABSTRACTThe WW and C2 domain containing (WWC) protein family functions as scaffolds regulating cell proliferation and organ growth control through the Hippo signaling pathway. However, their pan-cancer dysregulation and mechanistic roles in signaling transduction have remained unclear. We performed integrated pan-cancer analyses of WWC family gene expression using data from The Cancer Genome Atlas (TCGA) across 33 different cancer types. Prognostic relevance was evaluated by survival analyses. WWC genetic alterations, DNA methylation,...
Source: Cellular Signalling - January 8, 2024 Category: Cytology Authors: Hongmei Huang Jiaji Gu Xinjie Kuang Yonghui Yu Boqi Rao Shenying Fang Jiachun Lu Fuman Qiu Source Type: research
An integrative pan-cancer analysis of WWC family genes and functional validation in lung cancer
Cell Signal. 2024 Jan 6:111034. doi: 10.1016/j.cellsig.2024.111034. Online ahead of print.ABSTRACTThe WW and C2 domain containing (WWC) protein family functions as scaffolds regulating cell proliferation and organ growth control through the Hippo signaling pathway. However, their pan-cancer dysregulation and mechanistic roles in signaling transduction have remained unclear. We performed integrated pan-cancer analyses of WWC family gene expression using data from The Cancer Genome Atlas (TCGA) across 33 different cancer types. Prognostic relevance was evaluated by survival analyses. WWC genetic alterations, DNA methylation,...
Source: Cellular Signalling - January 8, 2024 Category: Cytology Authors: Hongmei Huang Jiaji Gu Xinjie Kuang Yonghui Yu Boqi Rao Shenying Fang Jiachun Lu Fuman Qiu Source Type: research
Structures, functions, and regulatory networks of universal stress proteins in clinically relevant pathogenic Bacteria
Cell Signal. 2024 Jan 5:111032. doi: 10.1016/j.cellsig.2023.111032. Online ahead of print.ABSTRACTUniversal stress proteins are a class of proteins widely present in bacteria, archaea, plants, and invertebrates, playing essential roles in bacterial adaptation to various environmental stresses. The functions of bacterial universal stress proteins are versatile, including resistance to oxidative stress, maintenance of cell wall integrity, DNA damage repair, regulation of cell division and growth, among others. When facing stresses such as temperature changes, pH shifts, fluctuations in oxygen concentration, and exposure to t...
Source: Cellular Signalling - January 7, 2024 Category: Cytology Authors: Tao Yan Min Li Qiuyan Wang Meng Wang Lijuan Liu Chengcheng Ma Xiaohong Xiang Qiang Zhou Zhou Liu Zhen Gong Source Type: research
Glycyrrhizic acid alleviated MI/R-induced injuries by inhibiting Hippo/YAP signaling pathways
CONCLUSION: This study suggests that GA regulates YAP nuclear translocation by inhibiting the Hippo/YAP signaling pathway, which protects ists against MI/R injury. This finding may present a novel therapeutic approach for the treatment of MI/R.PMID:38185229 | DOI:10.1016/j.cellsig.2024.111036 (Source: Cellular Signalling)
Source: Cellular Signalling - January 7, 2024 Category: Cytology Authors: Xian Cheng Yanwu Liu Bingcai Qi Yuchao Wang Yue Zheng Xiaoyu Liang Yun Chang Meng Ning Wenqing Gao Tong Li Source Type: research
Hippo/YAP1 promotes osteoporotic mice bone defect repair via the activating of Wnt signaling pathway
CONCLUSION: This study elucidates the role of Hippo/YAP1 in promoting the repair of osteoporotic bone defects in aged mice. Mechanistically, YAP1 functions by activating the Wnt/β-catenin pathway, and this process is not independent of TEAD1.PMID:38184268 | DOI:10.1016/j.cellsig.2024.111037 (Source: Cellular Signalling)
Source: Cellular Signalling - January 6, 2024 Category: Cytology Authors: Kehan Li Linan Liu Hanghang Liu Yao Liu Jiawei Xing Jian Song En Luo Source Type: research
Hippo/YAP1 promotes osteoporotic mice bone defect repair via the activating of Wnt signaling pathway
CONCLUSION: This study elucidates the role of Hippo/YAP1 in promoting the repair of osteoporotic bone defects in aged mice. Mechanistically, YAP1 functions by activating the Wnt/β-catenin pathway, and this process is not independent of TEAD1.PMID:38184268 | DOI:10.1016/j.cellsig.2024.111037 (Source: Cellular Signalling)
Source: Cellular Signalling - January 6, 2024 Category: Cytology Authors: Kehan Li Linan Liu Hanghang Liu Yao Liu Jiawei Xing Jian Song En Luo Source Type: research
Mitochondrial quality control in liver fibrosis: Epigenetic hallmarks and therapeutic strategies
CONCLUSION: Mitochondrial quality control and epigenetic mechanisms are intricately linked to the pathogenesis of liver fibrosis. Understanding these molecular interactions provides insight into potential therapeutic strategies. Further research is necessary to translate these findings into clinical applications, with a focus on developing epigenetic drugs to ameliorate liver fibrosis by modulating MQC and epigenetic pathways.PMID:38182067 | DOI:10.1016/j.cellsig.2024.111035 (Source: Cellular Signalling)
Source: Cellular Signalling - January 5, 2024 Category: Cytology Authors: Lin Jia Yang Yang Feng Sun Hui Tao Chao Lu Jing-Jing Yang Source Type: research
