The IGF2BP2-lncRNA TRPC7-AS1 axis promotes hepatocellular carcinoma cell proliferation and invasion
Cell Signal. 2024 Feb 4:111078. doi: 10.1016/j.cellsig.2024.111078. Online ahead of print.ABSTRACTHepatocellular carcinoma(HCC) is one of the most common tumors in the world. Human insulin-like growth factor 2(IGF2) mRNA binding protein 2(IGF2BP2) plays an important role in the progression of hepatocellular carcinoma. Additionally, long non-coding RNA(lncRNA) has been confirmed as a key regulator of hepatocellular carcinoma occurrence. However, the function of TRPC7-AS1 has not been verified in hepatocellular carcinoma. The research results revealed that high IGF2BP2 expression was associated with a decreased survival rate...
Source: Cellular Signalling - February 6, 2024 Category: Cytology Authors: Xu Zhang Zilin Li Huizong Nie Yue Huang Jingyang Du Yiling Xi Chaoqin Guo Mingshan Mu Xiangyu Li Xiaoliang Zheng Qiuran Xu Dongsheng Huang Linglan Tu Liyan Cheng Source Type: research
FATP2 activates PI3K/Akt/mTOR pathway by inhibiting ATF3 and promotes the occurrence and development of bladder cancer
This study delved into the function of FATP2 in BLCA through a succession of experiments in vivo and in vitro, employing techniques as quantitative real-time polymerase chain reaction (qRT-PCR), RNA sequencing, transwell assays, immunofluorescence, western blot,and others to dissect its mechanistic actions. The findings revealed that an oncogenic function is executed by FATP2 in bladder cancer, significantly impacting the proliferation and migration capabilities, thereby affecting the prognosis of BLCA patients. Furthermore, A suppression that relies on both time and concentration of BLCA proliferation and migration, trigg...
Source: Cellular Signalling - February 5, 2024 Category: Cytology Authors: Ming Jiang Ru Chen Bing Hu Situ Xiong Sheng Li Bin Fu Xiaoqiang Liu Source Type: research
TMEM16A inhibits renal tubulointerstitial fibrosis via Wnt/ β-catenin signaling during hypertension nephropathy
CONCLUSION: In angiotensin II (Ang II)-induced hypertensive nephropathy, TMEM16A was identified as a key player inhibiting the detrimental changes in renal tubules, suggesting a potential avenue for mitigating renal damage in hypertensive nephropathy.PMID:38316267 | DOI:10.1016/j.cellsig.2024.111088 (Source: Cellular Signalling)
Source: Cellular Signalling - February 5, 2024 Category: Cytology Authors: Feng Wang Yiqing Zhang Min Gao Xuelin Zeng Source Type: research
Machine learning combined with single-cell analysis reveals predictive capacity and immunotherapy response of T cell exhaustion-associated lncRNAs in uterine corpus endometrial carcinoma
CONCLUSIONS: The association between TEXLs and UCEC was methodically elucidated by our investigation. A stable pTEXLs risk prediction model and a diagnosis model for UCEC were also established.PMID:38311301 | DOI:10.1016/j.cellsig.2024.111077 (Source: Cellular Signalling)
Source: Cellular Signalling - February 4, 2024 Category: Cytology Authors: Feng Jiang Ziyu Tao Yun Zhang Xiaoyan Xie Yunlei Bao Yifang Hu Jingxin Ding Chuyan Wu Source Type: research
Drp1-mediated mitochondrial fission promotes pulmonary fibrosis progression through the regulation of lipid metabolic reprogramming by ROS/HIF-1 α
CONCLUSION: In PF, inhibition of Drp1 can prevent mitochondrial fission in fibroblasts and regulate lipid metabolism reprogramming through ROS/HIF-1α; thus, fibroblast activation was inhibited, alleviating the progression of PF.PMID:38311302 | DOI:10.1016/j.cellsig.2024.111075 (Source: Cellular Signalling)
Source: Cellular Signalling - February 4, 2024 Category: Cytology Authors: Zhongkai Tong Xuekui Du Ying Zhou Fangxue Jing JiangPo Ma Yingying Feng Saiyun Lou Qiong Wang Zhaoxing Dong Source Type: research
Targeting inhibition of TCTP could inhibit proliferation and induce apoptosis in AML cells
In this study, we found that the protein level of TCTP was significantly reduced in acute promyelocytic leukemia cell line NB4 transfected with retinoic acid-induced gene G (RIG-G). The RIG-G was found in our previous work as a key mediator of anti-proliferative activity in retinoid/interferon-related pathways. Here, we tried to further explore the function of TCTP in the development of acute myeloid leukemia (AML) from different levels. Our results showed that inhibiting TCTP expression could attenuate AML cells proliferation and induce apoptosis both in AML cell lines and in xenograft of NOD-SCID mice. In addition, eithe...
Source: Cellular Signalling - February 3, 2024 Category: Cytology Authors: Di Xia Gui-Ping Xu Ying-Ting Zhang Wei-Wei Yan Xiao-Rong Pan Jian-Hua Tong Source Type: research
Crosstalk between m6A modification and non-coding RNAs in HCC
Cell Signal. 2024 Feb 1:111076. doi: 10.1016/j.cellsig.2024.111076. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide, with high morbidity and occurrence. Although various therapeutic approaches have been rapidly developed in recent years, the underlying molecular mechanisms in the pathogenesis of HCC remain enigmatic. The N6-methyladenosine (m6A) RNA modification is believed to regulate RNA metabolism and further gene expression. This process is intricately regulated by multiple regulators, such as methylases and demethylases. Non-coding RNAs (ncRN...
Source: Cellular Signalling - February 3, 2024 Category: Cytology Authors: Zitong Qiu Xingxing Yuan Xinyue Wang Songjiang Liu Source Type: research
USP36-mediated PARP1 deubiquitination in doxorubicin-induced cardiomyopathy
In conclusion, these findings suggest that Dox promotes DIC progression by activating USP36-mediated PARP1 deubiquitination. This novel USP36/PARP1 axis may play a significant regulatory role in the pathogenesis of DIC.PMID:38307305 | DOI:10.1016/j.cellsig.2024.111070 (Source: Cellular Signalling)
Source: Cellular Signalling - February 2, 2024 Category: Cytology Authors: Dongchen Wang Zihao Jiang Junyan Kan Xiaomin Jiang Chang Pan Shijie You Ruirui Chang Juan Zhang Hongfeng Yang Linlin Zhu Yue Gu Source Type: research
Cuproptosis-associated genes (CAGs) contribute to the prognosis prediction and potential therapeutic targets in hepatocellular carcinoma
CONCLUSION: The findings have enhanced our comprehension of the cuproptosis characteristics in HCC, and stratification based on CuScore may potentially enhance the prediction of patients' prognosis and facilitate the development of effective and innovative treatment strategies.PMID:38307306 | DOI:10.1016/j.cellsig.2024.111072 (Source: Cellular Signalling)
Source: Cellular Signalling - February 2, 2024 Category: Cytology Authors: Xiaoli Shi Dongmin Shi Yefeng Yin Yuxiao Wu Wenwei Chen Yue Yu Xuehao Wang Source Type: research
Deciphering the immunological and prognostic features of hepatocellular carcinoma through ADP-ribosylation-related genes analysis and identify potential therapeutic target ARFIP2
CONCLUSIONS: The ADPRI can be used to accurately predict the prognosis and immunotherapeutic response of hepatocellular carcinoma patients and providing valuable insights for future precision treatment of patients with hepatocellular carcinoma.PMID:38302034 | DOI:10.1016/j.cellsig.2024.111073 (Source: Cellular Signalling)
Source: Cellular Signalling - February 1, 2024 Category: Cytology Authors: Fenfen Jiang Yan Xu Zhuang Jiang Bin Hu Qing Lv Zhiyong Wang Source Type: research
Multi-omics reveals the switch role of abnormal methylation in the regulation of decidual macrophages function in recurrent spontaneous abortion
Cell Signal. 2024 Jan 29;117:111071. doi: 10.1016/j.cellsig.2024.111071. Online ahead of print.ABSTRACTRSA, recurrent spontaneous abortion, often causes serious physical damage and psychological pressure in reproductive women with unclarified pathogenesis. Abnormal function of decidual cells and aberrant DNA methylation have been reported to cause RSA, but their association remains unclear. Here, we integrated transcriptome, DNA methylome, and scRNA-seq to clarify the regulatory relationship between DNA methylation and decidual cells in RSA. We found that DNA methylation mainly influenced the function of decidual macrophag...
Source: Cellular Signalling - January 31, 2024 Category: Cytology Authors: Qian Li Lei Zhang Hua Zou Tingjia Chai Yan Su Yan Shen Xiao He Hongbo Qi Chunli Li Source Type: research
Transmembrane protein TMEM97 and epigenetic reader BAHCC1 constitute an axis that supports pro-inflammatory cytokine expression
Cell Signal. 2024 Jan 28;116:111069. doi: 10.1016/j.cellsig.2024.111069. Online ahead of print.ABSTRACTPro-inflammatory cytokine production by the retinal pigment epithelium (RPE) is a key etiology in retinal degenerative diseases, yet the underlying mechanisms are not well understood. TMEM97 is a scarcely studied transmembrane protein recently implicated in retinal degeneration. BAH domain coiled coil 1 (BAHCC1) is a newly discovered histone code reader involved in oncogenesis. A role for TMEM97 and BAHCC1 in RPE inflammation was not known. Here we found that they constitute a novel axis regulating pro-inflammatory cytoki...
Source: Cellular Signalling - January 30, 2024 Category: Cytology Authors: Jing Li Hongtao Shen Lian-Wang Guo Source Type: research
Transcriptome sequencing analysis reveals miR-30c-5p promotes ferroptosis in cervical cancer and inhibits growth and metastasis of cervical cancer xenografts by targeting the METTL3/KRAS axis
Cell Signal. 2024 Jan 27:111068. doi: 10.1016/j.cellsig.2024.111068. Online ahead of print.ABSTRACTCervical cancer is the most common malignant tumor in the female reproductive system worldwide, and its molecular mechanisms remain complex and poorly understood. Various techniques, including transcriptome sequencing, RT-qPCR, ELISA, immunofluorescence, Western blot, CCK-8 assay, Transwell assay, and xenograft models, were employed to investigate gene/miRNA expression, cellular proliferation, migration, and the interactions between miR-30c-5p, METTL3, and KRAS. Our transcriptome sequencing results demonstrated a significant ...
Source: Cellular Signalling - January 29, 2024 Category: Cytology Authors: Yangmei Gong Guifang Luo Shufen Zhang Yijing Chen Yi Hu Source Type: research
Immortalised chronic myeloid leukemia (CML) derived mesenchymal stromal cells (MSCs) line retains the immunomodulatory and chemoprotective properties of CML patient-derived MSCs
Cell Signal. 2024 Jan 27;116:111067. doi: 10.1016/j.cellsig.2024.111067. Online ahead of print.ABSTRACTDespite the success of Tyrosine kinase inhibitors (TKIs) in treating chronic myeloid leukemia (CML), leukemic stem cells (LSCs) persist, contributing to relapse and resistance. CML Mesenchymal Stromal Cells (MSCs) help in LSC maintenance and protection from TKIs. However, the limited passage and self-differentiation abilities of primary CML MSCs hinder extensive research. To overcome this, we generated and characterized an immortalised CML patient-derived MSC (iCML MSC) line and assessed its role in LSC maintenance. We al...
Source: Cellular Signalling - January 28, 2024 Category: Cytology Authors: Esther Sathya Bama Benjamin Elizabeth Vinod Raveen Stephen Stallon Illangeswaran Bharathi M Rajamani Rakhi Thalayattu Vidhyadharan Abhirup Bagchi Arnab Maity Ajith Mohan Ganesh Parasuraman Soosai Manickam Amirtham Aby Abraham Shaji R Velayudhan Poonkuzhal Source Type: research
GCN5L1-mediated acetylation prevents Rictor degradation in cardiac cells after hypoxic stress
Cell Signal. 2024 Jan 26;116:111065. doi: 10.1016/j.cellsig.2024.111065. Online ahead of print.ABSTRACTCardiomyocyte apoptosis and cardiac fibrosis are the leading causes of mortality in patients with ischemic heart disease. As such, these processes represent potential therapeutic targets to treat heart failure resulting from ischemic insult. We previously demonstrated that the mitochondrial acetyltransferase protein GCN5L1 regulates cardiomyocyte cytoprotective signaling in ischemia-reperfusion injury in vivo and hypoxia-reoxygenation injury in vitro. The current study investigated the mechanism underlying GCN5L1-mediated...
Source: Cellular Signalling - January 28, 2024 Category: Cytology Authors: Paramesha Bugga Janet R Manning Bellina A S Mushala Michael W Stoner John Sembrat Iain Scott Source Type: research
