Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons
Cell Signal. 2024 Mar 29:111153. doi: 10.1016/j.cellsig.2024.111153. Online ahead of print.ABSTRACTThe glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor (GPCR) which plays important physiological roles in insulin release and promoting fullness. GLP-1R agonists initiate cellular responses by cyclic AMP (cAMP) pathway signal transduction. Understanding of the potential of GLP-1R agonists in the treatment of type 2 diabetes may be advanced by considering the cAMP dynamics for agonists at GLP-1R in both pancreatic β-cells (important in insulin release) and neurons (important in appetite regulat...
Source: Cellular Signalling - March 31, 2024 Category: Cytology Authors: L J Bridge S Chen B Jones Source Type: research
Computational modelling of dynamic cAMP responses to GPCR agonists for exploration of GLP-1R ligand effects in pancreatic β-cells and neurons
Cell Signal. 2024 Mar 29:111153. doi: 10.1016/j.cellsig.2024.111153. Online ahead of print.ABSTRACTThe glucagon-like peptide-1 receptor (GLP-1R) is a class B G protein-coupled receptor (GPCR) which plays important physiological roles in insulin release and promoting fullness. GLP-1R agonists initiate cellular responses by cyclic AMP (cAMP) pathway signal transduction. Understanding of the potential of GLP-1R agonists in the treatment of type 2 diabetes may be advanced by considering the cAMP dynamics for agonists at GLP-1R in both pancreatic β-cells (important in insulin release) and neurons (important in appetite regulat...
Source: Cellular Signalling - March 31, 2024 Category: Cytology Authors: L J Bridge S Chen B Jones Source Type: research
Deciphering the role of SMARCA4 in cardiac disorders: Insights from single-cell studies on dilated cardiomyopathy and coronary heart disease
CONCLUSION: This study provides a clearer understanding of cell-type dynamics in heart diseases, emphasizing the role of fibroblasts and the significance of SMARCA4 in their function. Our results offer insights into the cellular mechanisms underlying DCM and CHD, potentially guiding future therapeutic strategies.PMID:38552892 | DOI:10.1016/j.cellsig.2024.111150 (Source: Cellular Signalling)
Source: Cellular Signalling - March 29, 2024 Category: Cytology Authors: Li Liu Chengban Li Linxing Yu Yubo Wang Xingshou Pan Jianjun Huang Source Type: research
Deciphering the role of SMARCA4 in cardiac disorders: Insights from single-cell studies on dilated cardiomyopathy and coronary heart disease
CONCLUSION: This study provides a clearer understanding of cell-type dynamics in heart diseases, emphasizing the role of fibroblasts and the significance of SMARCA4 in their function. Our results offer insights into the cellular mechanisms underlying DCM and CHD, potentially guiding future therapeutic strategies.PMID:38552892 | DOI:10.1016/j.cellsig.2024.111150 (Source: Cellular Signalling)
Source: Cellular Signalling - March 29, 2024 Category: Cytology Authors: Li Liu Chengban Li Linxing Yu Yubo Wang Xingshou Pan Jianjun Huang Source Type: research
Prognostic value and potential function of a novel heme-related LncRNAs signature in gastric cancer
In conclusion, our HMlncSig model has significant predictive value for the prognosis of GC patients and can provide clinical guidance for personalized immunotherapy.PMID:38548123 | DOI:10.1016/j.cellsig.2024.111152 (Source: Cellular Signalling)
Source: Cellular Signalling - March 28, 2024 Category: Cytology Authors: Shuo Ma Wei Liao Yinhao Chen Lin Gan Source Type: research
Prognostic value and potential function of a novel heme-related LncRNAs signature in gastric cancer
In conclusion, our HMlncSig model has significant predictive value for the prognosis of GC patients and can provide clinical guidance for personalized immunotherapy.PMID:38548123 | DOI:10.1016/j.cellsig.2024.111152 (Source: Cellular Signalling)
Source: Cellular Signalling - March 28, 2024 Category: Cytology Authors: Shuo Ma Wei Liao Yinhao Chen Lin Gan Source Type: research
E2F8-CENPL pathway contributes to homologous recombination repair and chemoresistance in breast cancer
Cell Signal. 2024 Mar 22:111151. doi: 10.1016/j.cellsig.2024.111151. Online ahead of print.ABSTRACTChemoresistance poses a significant obstacle to the treatment of breast cancer patients. The increased capacity of DNA damage repair is one of the mechanisms underlying chemoresistance. Bioinformatic analyses showed that E2F8 was associated with cell cycle progression and homologous recombination (HR) repair of DNA double-strand breaks (DSBs) in breast cancer. E2F8 knockdown suppressed cell growth and attenuated HR repair. Accordingly, E2F8 knockdown sensitized cancer cells to Adriamycin and Cisplatin. Centromere protein L (C...
Source: Cellular Signalling - March 24, 2024 Category: Cytology Authors: Shan Wang Yuhong Xia Yu Sun Wei Wang Lianfeng Shan Zhongbo Zhang Chenghai Zhao Source Type: research
Deciphering the role of glycosaminoglycans in GPCR signaling
Cell Signal. 2024 Mar 22;118:111149. doi: 10.1016/j.cellsig.2024.111149. Online ahead of print.ABSTRACTG protein-coupled receptors (GPCR) and glycosaminoglycans (GAGs) are two essential components of the cell surface that regulate physiological processes in the body. GPCRs are the most extensive family of transmembrane receptors that control cellular responses to extracellular stimuli, while GAGs are polysaccharides that contribute to the function of the extracellular matrix (ECM). Due to their proximity to the plasma membrane, GAGs participate in signal transduction by interacting with various extracellular molecules and ...
Source: Cellular Signalling - March 24, 2024 Category: Cytology Authors: Sofya Savransky Alex D White Jean-Pierre Vilardaga Source Type: research
E2F8-CENPL pathway contributes to homologous recombination repair and chemoresistance in breast cancer
Cell Signal. 2024 Mar 22:111151. doi: 10.1016/j.cellsig.2024.111151. Online ahead of print.ABSTRACTChemoresistance poses a significant obstacle to the treatment of breast cancer patients. The increased capacity of DNA damage repair is one of the mechanisms underlying chemoresistance. Bioinformatic analyses showed that E2F8 was associated with cell cycle progression and homologous recombination (HR) repair of DNA double-strand breaks (DSBs) in breast cancer. E2F8 knockdown suppressed cell growth and attenuated HR repair. Accordingly, E2F8 knockdown sensitized cancer cells to Adriamycin and Cisplatin. Centromere protein L (C...
Source: Cellular Signalling - March 24, 2024 Category: Cytology Authors: Shan Wang Yuhong Xia Yu Sun Wei Wang Lianfeng Shan Zhongbo Zhang Chenghai Zhao Source Type: research
Deciphering the role of glycosaminoglycans in GPCR signaling
Cell Signal. 2024 Mar 22;118:111149. doi: 10.1016/j.cellsig.2024.111149. Online ahead of print.ABSTRACTG protein-coupled receptors (GPCR) and glycosaminoglycans (GAGs) are two essential components of the cell surface that regulate physiological processes in the body. GPCRs are the most extensive family of transmembrane receptors that control cellular responses to extracellular stimuli, while GAGs are polysaccharides that contribute to the function of the extracellular matrix (ECM). Due to their proximity to the plasma membrane, GAGs participate in signal transduction by interacting with various extracellular molecules and ...
Source: Cellular Signalling - March 24, 2024 Category: Cytology Authors: Sofya Savransky Alex D White Jean-Pierre Vilardaga Source Type: research
E2F8-CENPL pathway contributes to homologous recombination repair and chemoresistance in breast cancer
Cell Signal. 2024 Mar 22:111151. doi: 10.1016/j.cellsig.2024.111151. Online ahead of print.ABSTRACTChemoresistance poses a significant obstacle to the treatment of breast cancer patients. The increased capacity of DNA damage repair is one of the mechanisms underlying chemoresistance. Bioinformatic analyses showed that E2F8 was associated with cell cycle progression and homologous recombination (HR) repair of DNA double-strand breaks (DSBs) in breast cancer. E2F8 knockdown suppressed cell growth and attenuated HR repair. Accordingly, E2F8 knockdown sensitized cancer cells to Adriamycin and Cisplatin. Centromere protein L (C...
Source: Cellular Signalling - March 24, 2024 Category: Cytology Authors: Shan Wang Yuhong Xia Yu Sun Wei Wang Lianfeng Shan Zhongbo Zhang Chenghai Zhao Source Type: research
Deciphering the role of glycosaminoglycans in GPCR signaling
Cell Signal. 2024 Mar 22:111149. doi: 10.1016/j.cellsig.2024.111149. Online ahead of print.ABSTRACTG protein-coupled receptors (GPCR) and glycosaminoglycans (GAGs) are two essential components of the cell surface that regulate physiological processes in the body. GPCRs are the most extensive family of transmembrane receptors that control cellular responses to extracellular stimuli, while GAGs are polysaccharides that contribute to the function of the extracellular matrix (ECM). Due to their proximity to the plasma membrane, GAGs participate in signal transduction by interacting with various extracellular molecules and cell...
Source: Cellular Signalling - March 24, 2024 Category: Cytology Authors: Sofya Savransky Alex D White Jean-Pierre Vilardaga Source Type: research
E2F8-CENPL pathway contributes to homologous recombination repair and chemoresistance in breast cancer
Cell Signal. 2024 Mar 22:111151. doi: 10.1016/j.cellsig.2024.111151. Online ahead of print.ABSTRACTChemoresistance poses a significant obstacle to the treatment of breast cancer patients. The increased capacity of DNA damage repair is one of the mechanisms underlying chemoresistance. Bioinformatic analyses showed that E2F8 was associated with cell cycle progression and homologous recombination (HR) repair of DNA double-strand breaks (DSBs) in breast cancer. E2F8 knockdown suppressed cell growth and attenuated HR repair. Accordingly, E2F8 knockdown sensitized cancer cells to Adriamycin and Cisplatin. Centromere protein L (C...
Source: Cellular Signalling - March 24, 2024 Category: Cytology Authors: Shan Wang Yuhong Xia Yu Sun Wei Wang Lianfeng Shan Zhongbo Zhang Chenghai Zhao Source Type: research
Deciphering the role of glycosaminoglycans in GPCR signaling
Cell Signal. 2024 Mar 22:111149. doi: 10.1016/j.cellsig.2024.111149. Online ahead of print.ABSTRACTG protein-coupled receptors (GPCR) and glycosaminoglycans (GAGs) are two essential components of the cell surface that regulate physiological processes in the body. GPCRs are the most extensive family of transmembrane receptors that control cellular responses to extracellular stimuli, while GAGs are polysaccharides that contribute to the function of the extracellular matrix (ECM). Due to their proximity to the plasma membrane, GAGs participate in signal transduction by interacting with various extracellular molecules and cell...
Source: Cellular Signalling - March 24, 2024 Category: Cytology Authors: Sofya Savransky Alex D White Jean-Pierre Vilardaga Source Type: research
E3 ubiquitin ligase CHIP interacts with transferrin receptor 1 for degradation and promotes cell proliferation through inhibiting ferroptosis in hepatocellular carcinoma
Cell Signal. 2024 Mar 21:111148. doi: 10.1016/j.cellsig.2024.111148. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the major form of liver malignancy with high incidence and mortality. Identifying novel biomarkers and understanding regulatory mechanisms underlying the development and progression of HCC are critical for improving diagnosis, treatment and patient outcomes. Carboxyl terminus of Hsc-70-interacting protein (CHIP) is a well-described U-box-type E3 ubiquitin ligase which promotes the ubiquitination and degradation of numerous tumor-associated proteins. Recent studies have shown that CHIP can pla...
Source: Cellular Signalling - March 23, 2024 Category: Cytology Authors: Miaomiao Shao Kangwei Qi Lanxin Wang Xiaoxuan Yu Qingyu Zhang Long Yu Lan Wang Caiting Yang Lu Fan Source Type: research
