4-amino-2-trifluoromethyl-phenyl retinate alleviates lipopolysaccharide-induced acute myocardial injury through activation of the KLF4/p62 axis
This study investigated the role of 4-amino-2-trifluoromethyl-phenyl retinate (ATPR), a derivative of ATRA, in myocardial injury caused by sepsis. Male C57BL/6 mice were intraperitoneally injected with LPS to establish a sepsis model. H9c2 cells were stimulated by LPS to establish an injury model. We observed that ATPR improved myocardial injury in mice, which was presented in terms of an increased glutathione (GSH) level and reduced production of malondialdehyde (MDA), as well as an increased number of mitochondrial cristae and maintenance of the mitochondrial membrane integrity. ATPR improved cardiac function in the LPS-...
Source: Cellular Signalling - December 4, 2023 Category: Cytology Authors: Zhangyong Dan Xiaorui Shi Chuanlin Shu Rumeng Zhu Yi Wang Huaqing Zhu Source Type: research
Tumor suppressor miR-361-3p inhibits prostate cancer progression through Gli1 and AKT/mTOR signaling pathway
CONCLUSIONS: Downregulation of miR-361-3p along the Gli1 axis promoted tumor malignancy. Collectively, the results of this study imply that miR-361-3p has the potential to be both a biomarker and therapeutic target in PCa.PMID:38048859 | DOI:10.1016/j.cellsig.2023.110998 (Source: Cellular Signalling)
Source: Cellular Signalling - December 4, 2023 Category: Cytology Authors: Shaocheng Wang Xiaoyu Huang Guangyu Zhang Zhijun Chen Han Guan Wensheng Zhou Source Type: research
M6A reader YTHDF1 promotes malignant progression of laryngeal squamous carcinoma through activating the EMT pathway by EIF4A3
This study delved into the function and mechanism of the m6A reading protein YTHDF1 in LSCC. It was found that YTHDF1 was highly expressed in the TCGA database and LSCC tissues. Cell function experiments confirmed that the downregulation of YTHDF1 significantly inhibited the proliferation, migration, and invasion ability of LSCC cells. Further studies revealed that EIF4A3 was a downstream target gene of YTHDF1, and knockdown of EIF4A3 similarly significantly inhibited the malignant progression of LSCC in both in vivo and in vitro experiments. The molecular mechanism studies suggested that YTHDF1-EIF4A3 may promote the mali...
Source: Cellular Signalling - December 4, 2023 Category: Cytology Authors: Huina Guo Qi Han Xiaoya Guan Zhongxun Li Ying Wang Long He Yujia Guo Liting Zhao Xuting Xue Hongliang Liu Chunming Zhang Source Type: research
Mitocurcumin utilizes oxidative stress to upregulate JNK/p38 signaling and overcomes Cytarabine resistance in acute myeloid leukemia
Cell Signal. 2023 Dec 2:111004. doi: 10.1016/j.cellsig.2023.111004. Online ahead of print.ABSTRACTAcute myeloid leukemia (AML) is a type of blood cancer that is characterized by the rapid growth of abnormal myeloid cells. The goal of AML treatment is to eliminate the leukemic blasts, which is accomplished through intensive chemotherapy. Cytarabine is a key component of the standard induction chemotherapy regimen for AML. However, despite a high remission rate, 70-80% of AML patients relapse and develop resistance to Cytarabine, leading to poor clinical outcomes. Mitocurcumin (MitoC), a derivative of curcumin that enters mi...
Source: Cellular Signalling - December 4, 2023 Category: Cytology Authors: Tarang Gaur Ahlam Ali Deepak Sharma Saurabh Kumar Gupta Vikram Gota Bhausaheb Bagal Uwe Platzbeckar Rohit Mishra Amit Dutt Navin Khattry Ken Mills Md Imtaiyaz Hassan Santosh Sandur Syed K Hasan Source Type: research
Leonurine ameliorates the STAT3 pathway through the upregulation of SHP-1 to retard the growth of hepatocellular carcinoma cells
In conclusion, Leo was demonstrated to induce cytotoxicity in HCC cells by mitigating the persistent of activation of STAT3 pathway.PMID:38048857 | DOI:10.1016/j.cellsig.2023.111003 (Source: Cellular Signalling)
Source: Cellular Signalling - December 4, 2023 Category: Cytology Authors: Young Yun Jung Chulwon Kim Muthu K Shanmugam Amudha Deivasigamani Arunachalam Chinnathambi Sulaiman Ali Alharbi Kanchugarakoppal S Rangappa Kam Man Hui Gautam Sethi Chakrabhavi Dhananjaya Mohan Kwang Seok Ahn Source Type: research
4-amino-2-trifluoromethyl-phenyl retinate alleviates lipopolysaccharide-induced acute myocardial injury through activation of the KLF4/p62 axis
This study investigated the role of 4-amino-2-trifluoromethyl-phenyl retinate (ATPR), a derivative of ATRA, in myocardial injury caused by sepsis. Male C57BL/6 mice were intraperitoneally injected with LPS to establish a sepsis model. H9c2 cells were stimulated by LPS to establish an injury model. We observed that ATPR improved myocardial injury in mice, which was presented in terms of an increased glutathione (GSH) level and reduced production of malondialdehyde (MDA), as well as an increased number of mitochondrial cristae and maintenance of the mitochondrial membrane integrity. ATPR improved cardiac function in the LPS-...
Source: Cellular Signalling - December 4, 2023 Category: Cytology Authors: Zhangyong Dan Xiaorui Shi Chuanlin Shu Rumeng Zhu Yi Wang Huaqing Zhu Source Type: research
Tumor suppressor miR-361-3p inhibits prostate cancer progression through Gli1 and AKT/mTOR signaling pathway
CONCLUSIONS: Downregulation of miR-361-3p along the Gli1 axis promoted tumor malignancy. Collectively, the results of this study imply that miR-361-3p has the potential to be both a biomarker and therapeutic target in PCa.PMID:38048859 | DOI:10.1016/j.cellsig.2023.110998 (Source: Cellular Signalling)
Source: Cellular Signalling - December 4, 2023 Category: Cytology Authors: Shaocheng Wang Xiaoyu Huang Guangyu Zhang Zhijun Chen Han Guan Wensheng Zhou Source Type: research
M6A reader YTHDF1 promotes malignant progression of laryngeal squamous carcinoma through activating the EMT pathway by EIF4A3
This study delved into the function and mechanism of the m6A reading protein YTHDF1 in LSCC. It was found that YTHDF1 was highly expressed in the TCGA database and LSCC tissues. Cell function experiments confirmed that the downregulation of YTHDF1 significantly inhibited the proliferation, migration, and invasion ability of LSCC cells. Further studies revealed that EIF4A3 was a downstream target gene of YTHDF1, and knockdown of EIF4A3 similarly significantly inhibited the malignant progression of LSCC in both in vivo and in vitro experiments. The molecular mechanism studies suggested that YTHDF1-EIF4A3 may promote the mali...
Source: Cellular Signalling - December 4, 2023 Category: Cytology Authors: Huina Guo Qi Han Xiaoya Guan Zhongxun Li Ying Wang Long He Yujia Guo Liting Zhao Xuting Xue Hongliang Liu Chunming Zhang Source Type: research
DDX24 promotes tumor progression by mediating hexokinase-1 induced glycolysis in gastric cancer
Cell Signal. 2023 Dec 1:110995. doi: 10.1016/j.cellsig.2023.110995. Online ahead of print.ABSTRACTMetabolic reprogramming allows tumor cells to meet high demand of biogenesis and increased energy for rapid proliferation. Gastric cancer (GC) ranks among the most prevalent malignancies globally. Exploring the underlying mechanisms of glycolytic reprogramming in GC could provide new therapeutic target for GC treatment. Here, we showed that DEAD-box helicase 24 (DDX24) played a critical role in hexokinase-1 (HK1) induced glycolysis. DDX24 expression was significantly elevated in GC tissues and was closely associated with worse...
Source: Cellular Signalling - December 3, 2023 Category: Cytology Authors: Yuanyuan Ni Zhixiang Zhuang Source Type: research
SH2D4A inhibits esophageal squamous cell carcinoma progression through FAK/PI3K/AKT signaling pathway
In conclusion, our findings reveal that SH2D4A is a gene which can serve as a cancer suppressor in ESCC and may inhibits the ESCC progression by interfering with the FAK/PI3K/AKT signaling pathway. SH2D4A could act as a target for diagnostic or therapeutic purpose in ESCC.PMID:38043670 | DOI:10.1016/j.cellsig.2023.110997 (Source: Cellular Signalling)
Source: Cellular Signalling - December 3, 2023 Category: Cytology Authors: Haoming Shi Jun Luo Liu Ye Changzhu Duan Min Zhang Haoyu Ran Changying Li Qingchen Wu Yue Shao Source Type: research
DDX24 promotes tumor progression by mediating hexokinase-1 induced glycolysis in gastric cancer
Cell Signal. 2023 Dec 1:110995. doi: 10.1016/j.cellsig.2023.110995. Online ahead of print.ABSTRACTMetabolic reprogramming allows tumor cells to meet high demand of biogenesis and increased energy for rapid proliferation. Gastric cancer (GC) ranks among the most prevalent malignancies globally. Exploring the underlying mechanisms of glycolytic reprogramming in GC could provide new therapeutic target for GC treatment. Here, we showed that DEAD-box helicase 24 (DDX24) played a critical role in hexokinase-1 (HK1) induced glycolysis. DDX24 expression was significantly elevated in GC tissues and was closely associated with worse...
Source: Cellular Signalling - December 3, 2023 Category: Cytology Authors: Yuanyuan Ni Zhixiang Zhuang Source Type: research
SH2D4A inhibits esophageal squamous cell carcinoma progression through FAK/PI3K/AKT signaling pathway
In conclusion, our findings reveal that SH2D4A is a gene which can serve as a cancer suppressor in ESCC and may inhibits the ESCC progression by interfering with the FAK/PI3K/AKT signaling pathway. SH2D4A could act as a target for diagnostic or therapeutic purpose in ESCC.PMID:38043670 | DOI:10.1016/j.cellsig.2023.110997 (Source: Cellular Signalling)
Source: Cellular Signalling - December 3, 2023 Category: Cytology Authors: Haoming Shi Jun Luo Liu Ye Changzhu Duan Min Zhang Haoyu Ran Changying Li Qingchen Wu Yue Shao Source Type: research
Deubiquitinating enzyme PSMD7 promotes bladder cancer development: Involvement of RAB1A stabilization
CONCLUSIONS: Our study substantiated a novel mechanism by which PSMD7 stabilized RAB1A to accelerate the progression of BC.PMID:38040402 | DOI:10.1016/j.cellsig.2023.110996 (Source: Cellular Signalling)
Source: Cellular Signalling - December 1, 2023 Category: Cytology Authors: Jun Wang Tao Wang Yuan-Kang Feng Yu Liu Bo Fu Xiao-Tong Liu Qi-Zhe Wu Source Type: research
Deubiquitinating enzyme PSMD7 promotes bladder cancer development: Involvement of RAB1A stabilization
CONCLUSIONS: Our study substantiated a novel mechanism by which PSMD7 stabilized RAB1A to accelerate the progression of BC.PMID:38040402 | DOI:10.1016/j.cellsig.2023.110996 (Source: Cellular Signalling)
Source: Cellular Signalling - December 1, 2023 Category: Cytology Authors: Jun Wang Tao Wang Yuan-Kang Feng Yu Liu Bo Fu Xiao-Tong Liu Qi-Zhe Wu Source Type: research
The role of abnormal ubiquitination in hepatocellular carcinoma pathology
In conclusion, targeting the dysregulation of ubiquitination in HCC holds promise as a prospective and complementary therapeutic approach to existing treatments.PMID:38036196 | DOI:10.1016/j.cellsig.2023.110994 (Source: Cellular Signalling)
Source: Cellular Signalling - November 30, 2023 Category: Cytology Authors: Ming Zhang Tingju Wei Danfeng Guo Source Type: research
