Drp1-mediated mitochondrial fission promotes pulmonary fibrosis progression through the regulation of lipid metabolic reprogramming by ROS/HIF-1 α
CONCLUSION: In PF, inhibition of Drp1 can prevent mitochondrial fission in fibroblasts and regulate lipid metabolism reprogramming through ROS/HIF-1α; thus, fibroblast activation was inhibited, alleviating the progression of PF.PMID:38311302 | DOI:10.1016/j.cellsig.2024.111075 (Source: Cellular Signalling)
Source: Cellular Signalling - February 4, 2024 Category: Cytology Authors: Zhongkai Tong Xuekui Du Ying Zhou Fangxue Jing JiangPo Ma Yingying Feng Saiyun Lou Qiong Wang Zhaoxing Dong Source Type: research
Targeting inhibition of TCTP could inhibit proliferation and induce apoptosis in AML cells
In this study, we found that the protein level of TCTP was significantly reduced in acute promyelocytic leukemia cell line NB4 transfected with retinoic acid-induced gene G (RIG-G). The RIG-G was found in our previous work as a key mediator of anti-proliferative activity in retinoid/interferon-related pathways. Here, we tried to further explore the function of TCTP in the development of acute myeloid leukemia (AML) from different levels. Our results showed that inhibiting TCTP expression could attenuate AML cells proliferation and induce apoptosis both in AML cell lines and in xenograft of NOD-SCID mice. In addition, eithe...
Source: Cellular Signalling - February 3, 2024 Category: Cytology Authors: Di Xia Gui-Ping Xu Ying-Ting Zhang Wei-Wei Yan Xiao-Rong Pan Jian-Hua Tong Source Type: research
Crosstalk between m6A modification and non-coding RNAs in HCC
Cell Signal. 2024 Feb 1:111076. doi: 10.1016/j.cellsig.2024.111076. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide, with high morbidity and occurrence. Although various therapeutic approaches have been rapidly developed in recent years, the underlying molecular mechanisms in the pathogenesis of HCC remain enigmatic. The N6-methyladenosine (m6A) RNA modification is believed to regulate RNA metabolism and further gene expression. This process is intricately regulated by multiple regulators, such as methylases and demethylases. Non-coding RNAs (ncRN...
Source: Cellular Signalling - February 3, 2024 Category: Cytology Authors: Zitong Qiu Xingxing Yuan Xinyue Wang Songjiang Liu Source Type: research
USP36-mediated PARP1 deubiquitination in doxorubicin-induced cardiomyopathy
In conclusion, these findings suggest that Dox promotes DIC progression by activating USP36-mediated PARP1 deubiquitination. This novel USP36/PARP1 axis may play a significant regulatory role in the pathogenesis of DIC.PMID:38307305 | DOI:10.1016/j.cellsig.2024.111070 (Source: Cellular Signalling)
Source: Cellular Signalling - February 2, 2024 Category: Cytology Authors: Dongchen Wang Zihao Jiang Junyan Kan Xiaomin Jiang Chang Pan Shijie You Ruirui Chang Juan Zhang Hongfeng Yang Linlin Zhu Yue Gu Source Type: research
Cuproptosis-associated genes (CAGs) contribute to the prognosis prediction and potential therapeutic targets in hepatocellular carcinoma
CONCLUSION: The findings have enhanced our comprehension of the cuproptosis characteristics in HCC, and stratification based on CuScore may potentially enhance the prediction of patients' prognosis and facilitate the development of effective and innovative treatment strategies.PMID:38307306 | DOI:10.1016/j.cellsig.2024.111072 (Source: Cellular Signalling)
Source: Cellular Signalling - February 2, 2024 Category: Cytology Authors: Xiaoli Shi Dongmin Shi Yefeng Yin Yuxiao Wu Wenwei Chen Yue Yu Xuehao Wang Source Type: research
Deciphering the immunological and prognostic features of hepatocellular carcinoma through ADP-ribosylation-related genes analysis and identify potential therapeutic target ARFIP2
CONCLUSIONS: The ADPRI can be used to accurately predict the prognosis and immunotherapeutic response of hepatocellular carcinoma patients and providing valuable insights for future precision treatment of patients with hepatocellular carcinoma.PMID:38302034 | DOI:10.1016/j.cellsig.2024.111073 (Source: Cellular Signalling)
Source: Cellular Signalling - February 1, 2024 Category: Cytology Authors: Fenfen Jiang Yan Xu Zhuang Jiang Bin Hu Qing Lv Zhiyong Wang Source Type: research
Multi-omics reveals the switch role of abnormal methylation in the regulation of decidual macrophages function in recurrent spontaneous abortion
Cell Signal. 2024 Jan 29;117:111071. doi: 10.1016/j.cellsig.2024.111071. Online ahead of print.ABSTRACTRSA, recurrent spontaneous abortion, often causes serious physical damage and psychological pressure in reproductive women with unclarified pathogenesis. Abnormal function of decidual cells and aberrant DNA methylation have been reported to cause RSA, but their association remains unclear. Here, we integrated transcriptome, DNA methylome, and scRNA-seq to clarify the regulatory relationship between DNA methylation and decidual cells in RSA. We found that DNA methylation mainly influenced the function of decidual macrophag...
Source: Cellular Signalling - January 31, 2024 Category: Cytology Authors: Qian Li Lei Zhang Hua Zou Tingjia Chai Yan Su Yan Shen Xiao He Hongbo Qi Chunli Li Source Type: research
Transmembrane protein TMEM97 and epigenetic reader BAHCC1 constitute an axis that supports pro-inflammatory cytokine expression
Cell Signal. 2024 Jan 28;116:111069. doi: 10.1016/j.cellsig.2024.111069. Online ahead of print.ABSTRACTPro-inflammatory cytokine production by the retinal pigment epithelium (RPE) is a key etiology in retinal degenerative diseases, yet the underlying mechanisms are not well understood. TMEM97 is a scarcely studied transmembrane protein recently implicated in retinal degeneration. BAH domain coiled coil 1 (BAHCC1) is a newly discovered histone code reader involved in oncogenesis. A role for TMEM97 and BAHCC1 in RPE inflammation was not known. Here we found that they constitute a novel axis regulating pro-inflammatory cytoki...
Source: Cellular Signalling - January 30, 2024 Category: Cytology Authors: Jing Li Hongtao Shen Lian-Wang Guo Source Type: research
Transcriptome sequencing analysis reveals miR-30c-5p promotes ferroptosis in cervical cancer and inhibits growth and metastasis of cervical cancer xenografts by targeting the METTL3/KRAS axis
Cell Signal. 2024 Jan 27:111068. doi: 10.1016/j.cellsig.2024.111068. Online ahead of print.ABSTRACTCervical cancer is the most common malignant tumor in the female reproductive system worldwide, and its molecular mechanisms remain complex and poorly understood. Various techniques, including transcriptome sequencing, RT-qPCR, ELISA, immunofluorescence, Western blot, CCK-8 assay, Transwell assay, and xenograft models, were employed to investigate gene/miRNA expression, cellular proliferation, migration, and the interactions between miR-30c-5p, METTL3, and KRAS. Our transcriptome sequencing results demonstrated a significant ...
Source: Cellular Signalling - January 29, 2024 Category: Cytology Authors: Yangmei Gong Guifang Luo Shufen Zhang Yijing Chen Yi Hu Source Type: research
Immortalised chronic myeloid leukemia (CML) derived mesenchymal stromal cells (MSCs) line retains the immunomodulatory and chemoprotective properties of CML patient-derived MSCs
Cell Signal. 2024 Jan 27;116:111067. doi: 10.1016/j.cellsig.2024.111067. Online ahead of print.ABSTRACTDespite the success of Tyrosine kinase inhibitors (TKIs) in treating chronic myeloid leukemia (CML), leukemic stem cells (LSCs) persist, contributing to relapse and resistance. CML Mesenchymal Stromal Cells (MSCs) help in LSC maintenance and protection from TKIs. However, the limited passage and self-differentiation abilities of primary CML MSCs hinder extensive research. To overcome this, we generated and characterized an immortalised CML patient-derived MSC (iCML MSC) line and assessed its role in LSC maintenance. We al...
Source: Cellular Signalling - January 28, 2024 Category: Cytology Authors: Esther Sathya Bama Benjamin Elizabeth Vinod Raveen Stephen Stallon Illangeswaran Bharathi M Rajamani Rakhi Thalayattu Vidhyadharan Abhirup Bagchi Arnab Maity Ajith Mohan Ganesh Parasuraman Soosai Manickam Amirtham Aby Abraham Shaji R Velayudhan Poonkuzhal Source Type: research
GCN5L1-mediated acetylation prevents Rictor degradation in cardiac cells after hypoxic stress
Cell Signal. 2024 Jan 26;116:111065. doi: 10.1016/j.cellsig.2024.111065. Online ahead of print.ABSTRACTCardiomyocyte apoptosis and cardiac fibrosis are the leading causes of mortality in patients with ischemic heart disease. As such, these processes represent potential therapeutic targets to treat heart failure resulting from ischemic insult. We previously demonstrated that the mitochondrial acetyltransferase protein GCN5L1 regulates cardiomyocyte cytoprotective signaling in ischemia-reperfusion injury in vivo and hypoxia-reoxygenation injury in vitro. The current study investigated the mechanism underlying GCN5L1-mediated...
Source: Cellular Signalling - January 28, 2024 Category: Cytology Authors: Paramesha Bugga Janet R Manning Bellina A S Mushala Michael W Stoner John Sembrat Iain Scott Source Type: research
ING3 inhibits the malignant progression of lung adenocarcinoma by negatively regulating ITGB4 expression to inactivate Src/FAK signaling
This study aimed to elucidate the role of ING3 in the progression of LUAD and investigate the underlying mechanism related to integrin β4 (ITGB4) and Src/focal adhesion kinase (FAK) signaling. ING3 expression in LUAD tissues and the correlation between ING3 expression and prognosis were analyzed by bioinformatics databases. After evaluating ING3 expression in LUAD cells, ING3 was overexpressed to assess the proliferation, cell cycle arrest, migration and invasion of LUAD cells. Then, ITGB4 was upregulated to observe the changes of malignant activities in ING3-overexpressed LUAD cells. The transplantation tumor model of NC...
Source: Cellular Signalling - January 28, 2024 Category: Cytology Authors: Shiliang Cheng Meng Li Wen Zheng Chunguang Li Zhihao Hao Yonggang Dai Jue Wang Jinhua Zhuo Lu Zhang Source Type: research
SMPDL3B is palmitoylated and stabilized by ZDHHC5, and its silencing aggravates diabetic retinopathy of db/db mice: Activation of NLRP3/NF- κB pathway
Cell Signal. 2024 Jan 23;116:111064. doi: 10.1016/j.cellsig.2024.111064. Online ahead of print.ABSTRACTAbnormal inflammation of vascular endothelial cells occurs frequently in diabetic retinopathy (DR). Sphingomyelin phosphodiesterase acid-like 3B (SMPDL3B) is a lipid raft enzyme and plays an anti-inflammatory role in various diseases but its function in DR-related vascular endothelial dysfunction remains unknown. We first found that SMPDL3B expression was upregulated from week 10 to 18 in the retinal tissues of db/db mice. Particularly, the high expression of SMPDL3B was mainly observed in retinal vascular endothelium of ...
Source: Cellular Signalling - January 24, 2024 Category: Cytology Authors: Yun Zhou Song Yue Lihua Li Jiahua Zhang Lei Chen Jun Chen Source Type: research
Evidence for heterodimerization and functional interaction of the urotensin II and the angiotensin II type 1 receptors
Cell Signal. 2024 Jan 21;116:111056. doi: 10.1016/j.cellsig.2024.111056. Online ahead of print.ABSTRACTDespite the observation of synergistic interactions between the urotensinergic and angiotensinergic systems, the interplay between the urotensin II receptor (hUT) and the angiotensin II type 1 receptor (hAT1R) in regulating cellular signaling remains incompletely understood. Notably, the putative interaction between hUT and hAT1R could engender reciprocal allosteric modulation of their signaling signatures, defining a unique role for these complexes in cardiovascular physiology and pathophysiology. Using a combination of ...
Source: Cellular Signalling - January 23, 2024 Category: Cytology Authors: Hassan Nassour Darlaine P étrin Dominic Devost Etienne Billard Rory Sleno Terence E H ébert David Chatenet Source Type: research
Harnessing GMNP-loaded BMSC-derived EVs to target miR-3064-5p via MEG3 overexpression: Implications for diabetic osteoporosis therapy in rats
In conclusion, GMNPs loaded with BMSC-EVs, through the delivery of MEG3 targeting miR-3064-5p, can effectively promote NR4A3 expression, activate the PINK1/Parkin pathway, and thereby enhance osteoblast proliferation and differentiation, offering a promising treatment for DO.PMID:38246512 | DOI:10.1016/j.cellsig.2024.111055 (Source: Cellular Signalling)
Source: Cellular Signalling - January 21, 2024 Category: Cytology Authors: Chen Xu Zhaodong Wang Ya Jun Liu Keyou Duan Jianzhong Guan Source Type: research
