Drp1-mediated mitochondrial fission promotes pulmonary fibrosis progression through the regulation of lipid metabolic reprogramming by ROS/HIF-1 α

CONCLUSION: In PF, inhibition of Drp1 can prevent mitochondrial fission in fibroblasts and regulate lipid metabolism reprogramming through ROS/HIF-1α; thus, fibroblast activation was inhibited, alleviating the progression of PF.PMID:38311302 | DOI:10.1016/j.cellsig.2024.111075

Source: Cellular Signalling - February 4, 2024 Category: Cytology Authors: Zhongkai Tong Xuekui Du Ying Zhou Fangxue Jing JiangPo Ma Yingying Feng Saiyun Lou Qiong Wang Zhaoxing Dong Source Type: research