Gene behind long-recognized mitochondrial disease has highly varied effects
(Children's Hospital of Philadelphia) Mutations in the mitochondrial gene mt-ATP6, which encodes an essential part of the mitochondrial motor known as ATP synthase that generates cellular energy, are much more variable than previously thought. This prompts the need to develop more precise clinical tests that can better determine the course of treatment for patients affected by mitochondrial disorder. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 12, 2019 Category: International Medicine & Public Health Source Type: news

An existing drug may have therapeutic potential in mitochondrial disease
(Children's Hospital of Philadelphia) New preclinical findings from extensive cell and animal studies suggest that a drug already used for a rare kidney disease could benefit patients with some mitochondrial disorders -- complex conditions with severe energy deficiency for which no proven effective treatments exist. Future clinical research is needed to explore whether the drug, cysteamine bitartrate, will meaningfully benefit patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2019 Category: International Medicine & Public Health Source Type: news

What Is the Most Common Type of Cardiomyopathy?
Discussion Barth syndrome is characterized by a dilated cardiomyopathy, proximal skeletal muscle weakness, neutropenia and short stature that usually presents at birth or soon after. It is a rare X-linked recessive disease process caused by mutations in the TAZ gene. The TAZ gene codes for tafazzin which alters cardiolipin in mitochondria. Characteristic facies can be seen especially in infancy including a tall and broad forehead, prominent chin and full cheeks, larger ears, and deep-set eyes. Most patients present at birth or soon afterwards but some may not until later in life. Life expectancy is reduced with many childr...
Source: PediatricEducation.org - February 25, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Sea slug study illuminates how mitochondria move
(Scripps Research Institute) Defects in the transport of cells' energy organelles are a suspected cause of diseases including Alzheimer's, ALS, Huntington's and Parkinson's. A new study reveals the genetics behind mitochondrial shifts. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 16, 2019 Category: International Medicine & Public Health Source Type: news

Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells
In this study, we examined whether Mn2+ activates the multiprotein NLRP3 inflammasome complex to promote neuroinflammation. Exposing activated mouse microglial cells to Mn2+ substantially augmented NLRP3 abundance, caspase-1 cleavage, and maturation of the inflammatory cytokine interleukin-1β (IL-1β). Exposure of mice to Mn2+ had similar effects in brain microglial cells. Furthermore, Mn2+ impaired mitochondrial ATP generation, basal respiratory rate, and spare capacity in microglial cells. These data suggest that Mn-induced mitochondrial defects drove the inflammasome signal amplification. We found that Mn induc...
Source: Signal Transduction Knowledge Environment - January 8, 2019 Category: Science Authors: Sarkar, S., Rokad, D., Malovic, E., Luo, J., Harischandra, D. S., Jin, H., Anantharam, V., Huang, X., Lewis, M., Kanthasamy, A., Kanthasamy, A. G. Tags: STKE Research Articles Source Type: news

The road to a healthier heart: Study suggests using TCM to repair mitochondrial dysfunction
(Natural News) Ischemic heart disease, which is also called coronary heart disease, is the most prevalent and the deadliest heart problem in the U.S. According to the Centers for Disease Control and Prevention (CDC), this disease causes more than 370,000 deaths yearly. Moreover, ischemic heart disease also increases the risk of heart attacks. These cause further damage to... (Source: NaturalNews.com)
Source: NaturalNews.com - January 6, 2019 Category: Consumer Health News Source Type: news

An Experimental Procedure Could Help More Families Have Healthy Babies. But It ’s Not Allowed in the U.S.
When Noah Shulman was born a few days after Christmas 2016, his parents Kristelle and Evan had no reason to worry about him. The pregnancy went smoothly, and so did the birth. But within a few days of taking his first breath, Noah began to struggle. He wasn’t feeding, so he started losing weight. He was also lethargic. Several pediatricians reassured the Shulmans that they were probably just overly sensitive to Noah’s symptoms because Kristelle is a nurse and Evan is a physician assistant–a case of first-time-parent-white-coat syndrome. “They kind of dismissed us as neurotic parents,” says Eva...
Source: TIME: Science - January 3, 2019 Category: Science Authors: Alice Park Tags: Uncategorized fertility Research Source Type: news

An Experimental Procedure Could Help More Families Have Healthy Babies. But It ’s Not Allowed in the U.S.
When Noah Shulman was born a few days after Christmas 2016, his parents Kristelle and Evan had no reason to worry about him. The pregnancy went smoothly, and so did the birth. But within a few days of taking his first breath, Noah began to struggle. He wasn’t feeding, so he started losing weight. He was also lethargic. Several pediatricians reassured the Shulmans that they were probably just overly sensitive to Noah’s symptoms because Kristelle is a nurse and Evan is a physician assistant–a case of first-time-parent-white-coat syndrome. “They kind of dismissed us as neurotic parents,” says Eva...
Source: TIME: Health - January 3, 2019 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized fertility Research Source Type: news

Autophagy and mitochondria: Targets in neurodegenerative disorders
(Bentham Science Publishers) Cellular homeostasis depends on the timely clearance of damaged cellular organelles and proteins via pathways including autophagy. Mitochondria and mitochondrial autophagy play a vital role in cellular health and failure of these pathways can have a devastating effect on cellular homeostasis. Here, the researchers review the involvement of mitochondrial and autophagy dysfunction in neurodegenerative disorders specifically focusing on Alzheimer's, Parkinson's and Huntington's disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 26, 2018 Category: International Medicine & Public Health Source Type: news

Ohio State biotech spinoff Entrada raises $59M to tackle deadly disease with no other treatment
An Ohio State University spinoff developing a treatment for a deadly mitochondrial disease launched Tuesday in Boston with a $59 million round of venture capital investment. Entrada Therapeutics is using science developed by Ohio State University professor and company co-founder Dehua Pei to deliver treatment to previously un-druggable targets in the power center of a cell. The Series A investment announced Tuesday is the largest ever for an OSU spinoff, the school said. “Our commitment to… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - December 19, 2018 Category: Pharmaceuticals Authors: Allison DeAngelis Source Type: news

Ohio State biotech spinoff Entrada raises $59M to tackle deadly disease with no other treatment
An Ohio State University spinoff developing a treatment for a deadly mitochondrial disease launched Tuesday in Boston with a $59 million round of venture capital investment. Entrada Therapeutics is using science developed by Ohio State University professor and company co-founder Dehua Pei to deliver treatment to previously un-druggable targets in the power center of a cell. The Series A investment announced Tuesday is the largest ever for an OSU spinoff, the school said. “Our commitment to… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - December 19, 2018 Category: Biotechnology Authors: Allison DeAngelis Source Type: news

Ashkenazi Jewish founder mutation identified for Leigh Syndrome
(Children's Hospital of Philadelphia) Decades after two brothers died in childhood of a mitochondrial disease, researchers pinpointed the exact cause in a founder mutation among Ashkenazi Jews. The discoverers say the mutation should be added to prenatal carrier screening programs for prospective parents. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 15, 2018 Category: International Medicine & Public Health Source Type: news

Mount Sinai recognized for excellence in mitochondrial care
(The Mount Sinai Hospital / Mount Sinai School of Medicine) The Icahn School of Medicine at Mount Sinai has been recognized as a certified Mitochondrial Medicine Center by the Mitochondrial Care Network, a newly established collaborative founded by four national mitochondrial disease advocacy groups. The certification recognizes centers for dedication to mitochondrial medicine. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - October 29, 2018 Category: International Medicine & Public Health Source Type: news

ER-mitochondria cross-talk is regulated by the Ca2+ sensor NCS1 and is impaired in Wolfram syndrome
Communication between the endoplasmic reticulum (ER) and mitochondria plays a pivotal role in Ca2+ signaling, energy metabolism, and cell survival. Dysfunction in this cross-talk leads to metabolic and neurodegenerative diseases. Wolfram syndrome is a fatal neurodegenerative disease caused by mutations in the ER-resident protein WFS1. Here, we showed that WFS1 formed a complex with neuronal calcium sensor 1 (NCS1) and inositol 1,4,5-trisphosphate receptor (IP3R) to promote Ca2+ transfer between the ER and mitochondria. In addition, we found that NCS1 abundance was reduced in WFS1-null patient fibroblasts, which showed redu...
Source: Signal Transduction Knowledge Environment - October 23, 2018 Category: Science Authors: Angebault, C., Fauconnier, J., Patergnani, S., Rieusset, J., Danese, A., Affortit, C. A., Jagodzinska, J., Megy, C., Quiles, M., Cazevieille, C., Korchagina, J., Bonnet-Wersinger, D., Milea, D., Hamel, C., Pinton, P., Thiry, M., Lacampagne, A., Delprat, B Tags: STKE Research Articles Source Type: news

Advanced sequencing technology provides new insights into human mitochondrial diseases
(University of Helsinki) Researchers have for the first time been able to investigate the abundance and methyl modifications of all mitochondrial tRNAs in patients suffering from one of the most common inherited mitochondrial tRNA mutations. The analysis pipeline revealed quantitative changes that had dramatic effects on protein synthesis within mitochondria. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - October 18, 2018 Category: Biology Source Type: news

Genetic causes of mitochondrial disease identified in study
Researchers have identified previously unknown genetic causes of mitochondrial disease. (Source: Health News - UPI.com)
Source: Health News - UPI.com - October 4, 2018 Category: Consumer Health News Source Type: news

Chemotherapy may lead to mitochondrial dysfunction in skeletal muscle
(American Physiological Society) Chemotherapy drugs to treat breast cancer may promote muscle mitochondrial dysfunction, according to new research. Dysfunctional mitochondria, the energy centers of the cells, may contribute to fatigue and weakness that some people with breast cancer experience through the course of disease treatment. The study is published ahead of print in the American Journal of Physiology--Cell Physiology. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - October 4, 2018 Category: Cancer & Oncology Source Type: news

Mitochondrial diseases could be treated with gene therapy
Researchers have developed a genome editing tool for the potential treatment of mitochondrial diseases. The study applied an experimental gene therapy treatment in mice and successfully targeted and eliminated the damaged DNA in mitochondria. (Source: Medical Research Council General News)
Source: Medical Research Council General News - September 25, 2018 Category: Research Source Type: news

Gene therapy may be effective against mitochondrial diseases
A newly developed gene editing tool can potentially treat mitochondrial diseases, which occur when the energy-producing structures malfunction. (Source: Health News - UPI.com)
Source: Health News - UPI.com - September 24, 2018 Category: Consumer Health News Source Type: news

New research reveals a mitochondrial gene that protects against Alzheimer's disease
(University of Southern California) New research from USC has uncovered a previously unknown genetic risk factor for Alzheimer's disease and related dementias. The study provides insights on how these conditions, and other diseases of aging, might one day be treated and prevented. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 21, 2018 Category: International Medicine & Public Health Source Type: news

New research reveals a mitochondrial gene that protects against dementia and other diseases of aging
(University of Southern California) New research from USC has uncovered a previously unknown genetic risk factor for Alzheimer's disease and related dementias. The study provides insights on how these conditions, and other diseases of aging, might one day be treated and prevented. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - September 21, 2018 Category: International Medicine & Public Health Source Type: news

Researchers identify a new cause of childhood mitochondrial disease
(Newcastle University) A rapid genetic test developed by Newcastle researchers has identified the first four patients with inherited mutations in a new disease gene, a building block of complex I called NDUFA6. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - September 20, 2018 Category: International Medicine & Public Health Source Type: news

Big data studies scrutinize links between fatty liver disease and how cells make energy
(American Society for Biochemistry and Molecular Biology) Three recent studies investigate changes in mitochondria, the cell's energy producers, as fatty liver disease (NAFLD) progresses to steatohepatosis (NASH). The first two studies illuminate how mitochondrial energy production stutters and fails; the third describes how changes to the liver during disease progression affect the organ's use of nutrients to produce energy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 14, 2018 Category: International Medicine & Public Health Source Type: news

Changes in mitochondrial DNA control how nuclear DNA mutations are expressed in cardiomyopathy
(Children's Hospital of Philadelphia) Differences in the DNA within the mitochondria, the energy-producing structures within cells, can determine the severity and progression of heart disease caused by a nuclear DNA mutation. When combined with a mutation in nuclear DNA in animals, one mitochondrial DNA variant greatly worsened heart disease, while a different variant had a protective effect. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - September 11, 2018 Category: International Medicine & Public Health Source Type: news

Senior Research Laboratory Technician (Fixed Term)
We are looking for an experienced and enthusiastic individual to join the groups ofProfessor Abigail Fowden andDr Andrew Murray.Collectively, their research focuses on mitochondrial function during development and ageing, and how conditions during early life programme development can increase susceptibility to adult-onset degenerative diseases.The position is fixed-term, with funds available for 2 years in the first instance. The post holder will provide mainly molecular biology support, as well as some assistance with animal work, to ensure that the objectives of the research project are achieved.&nb...
Source: Society for Endocrinology - September 5, 2018 Category: Endocrinology Source Type: news

My Patient May Have a Mitochondrial Disease: What Should I Do? My Patient May Have a Mitochondrial Disease: What Should I Do?
All patients with a suspected mitochondrial disease should be seen by a mitochondrial medicine expert. But what can the primary care clinician do while waiting for that to happen?CHOP Expert Commentary (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - August 17, 2018 Category: Consumer Health News Tags: Pediatrics Commentary Source Type: news

Frontiers in Metabolism meeting focuses on mechanisms of metabolic diseases
(Morgridge Institute for Research) A new scientific meeting hosted by the Morgridge Institute for Research will focus on the underlying mechanisms of metabolic diseases and innovations in the tools used to study them. The broad swath of topics will span cancer metabolism to lipid dysregulation to mitochondrial signaling. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 1, 2018 Category: International Medicine & Public Health Source Type: news

Heat therapy boosts mitochondrial function in muscles
(American Physiological Society) A new study finds that long-term heat therapy may increase mitochondrial function in the muscles. The discovery could lead to new treatments for people with chronic illness or disease. The study--the first of its kind in humans--is published ahead of print in the Journal of Applied Physiology. (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - July 31, 2018 Category: International Medicine & Public Health Source Type: news

Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity
Mitochondria are integral to cellular energy metabolism and ATP production and are involved in regulating many cellular processes. Mitochondria produce reactive oxygen species (ROS), which not only can damage cellular components but also participate in signal transduction. The kinase ATM, which is mutated in the neurodegenerative, autosomal recessive disease ataxia-telangiectasia (A-T), is a key player in the nuclear DNA damage response. However, ATM also performs a redox-sensing function mediated through formation of ROS-dependent disulfide-linked dimers. We found that mitochondria-derived hydrogen peroxide promoted ATM d...
Source: Signal Transduction Knowledge Environment - July 10, 2018 Category: Science Authors: Zhang, Y., Lee, J.-H., Paull, T. T., Gehrke, S., DAlessandro, A., Dou, Q., Gladyshev, V. N., Schroeder, E. A., Steyl, S. K., Christian, B. E., Shadel, G. S. Tags: STKE Research Articles Source Type: news

The association between cortisol, oxytocin, and immune cell mitochondrial oxygen consumption in postpartum women with childhood maltreatment - Boeck C, Gumpp AM, Calzia E, Radermacher P, Waller C, Karabatsiakis A, Kolassa IT.
Childhood maltreatment (CM) is associated with an increased risk for the development of psychiatric and somatic diseases in later life. Individual risk and resilience factors may, however, influence how deep psychological stress gets under the skin. We hyp... (Source: SafetyLit)
Source: SafetyLit - June 18, 2018 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Mutation links bipolar disorder to mitochondrial disease
(RIKEN) Mutations in the gene ANT1 may confer a risk for bipolar disorder through a complex interplay between serotonin and mitochondrial signaling in the brain. These two pathways have been separately implicated in bipolar disorder, but the link between levels of the neurotransmitter serotonin and mitochondrial dysfunction had not been established. Researchers at the RIKEN Center for Brain Science (CBS) in Japan now report that mitochondrial dysfunction affects the activity of serotonergic neurons in mice with mutations of ANT1. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 11, 2018 Category: International Medicine & Public Health Source Type: news

What would help or hinder patient participation in mitochondrial disease clinical trials?
As clinical trials gear up with the aim of attaining the first FDA-approved treatments for mitochondrial disease, a new study reports for the first time what patients and families say would motivate them for or against participating in such research trials. Based in malfunctions in mitochondria, the tiny structures within cells that act as biological batteries, mitochondrial disease is a highly variable collection of energy deficiency disorders that can affect nearly any and all organs and systems - at any age. (Source: World Pharma News)
Source: World Pharma News - June 7, 2018 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Biomedical optics engineer Jesse Wilson named a Boettcher Investigator
(Colorado State University) Mitochondrial diseases are devastating illnesses caused by defects in cellular organelles called mitochondria. Their cells starved of energy, most stricken children die by age 12. There is no cure, and diagnosis can take months.Colorado State University biomedical engineer Jesse Wilson wants to change all of that. The assistant professor of electrical and computer engineering is proposing a radical new imaging technology that could diagnose mitochondrial defects in an instant. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 7, 2018 Category: International Medicine & Public Health Source Type: news

Mitochondrial Diseases: Current State of Understanding Mitochondrial Diseases: Current State of Understanding
Mitochondrial diseases can affect any system by causing any symptom in any organ by any mode of inheritance.CHOP Expert Commentary (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 11, 2018 Category: Consumer Health News Tags: Pediatrics Commentary Source Type: news

Antioxidants found to be effective in treating mitochondrial disease, preclinical trials find
(Natural News) In search of mitochondrial disease treatments, researchers found that some antioxidant compounds could be effective in treating mitochondrial disease. In their study, the researchers examined seven antioxidant compounds in two animal models of mitochondrial disease: Zebrafish (Danio rerio) and the worm species Caenorhabditis elegans. In addition, they used cultures of fibroblasts or skin... (Source: NaturalNews.com)
Source: NaturalNews.com - April 30, 2018 Category: Consumer Health News Source Type: news

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A
Mitofusins (MFNs) promote fusion-mediated mitochondrial content exchange and subcellular trafficking. Mutations in Mfn2 cause neurodegenerative Charcot-Marie-Tooth disease type 2A (CMT2A). We showed that MFN2 activity can be determined by Met376 and His380 interactions with Asp725 and Leu727 and controlled by PINK1 kinase–mediated phosphorylation of adjacent MFN2 Ser378. Small-molecule mimics of the peptide-peptide interface of MFN2 disrupted this interaction, allosterically activating MFN2 and promoting mitochondrial fusion. These first-in-class mitofusin agonists overcame dominant mitochondrial defects provoked in ...
Source: ScienceNOW - April 19, 2018 Category: Science Authors: Rocha, A. G., Franco, A., Krezel, A. M., Rumsey, J. M., Alberti, J. M., Knight, W. C., Biris, N., Zacharioudakis, E., Janetka, J. W., Baloh, R. H., Kitsis, R. N., Mochly-Rosen, D., Townsend, R. R., Gavathiotis, E., Dorn, G. W. Tags: Cell Biology, Medicine, Diseases reports Source Type: news

Poor muscle health a complication of type 1 diabetes
Even active young adults with the disease have mitochondrial changes linked to cell damage Related items fromOnMedica Final piece of type 1 diabetes puzzle solved Overview of type 1 diabetes All pregnant women with type 1 diabetes should be offered continuous glucose monitoring Intensive weight loss can ‘reverse’ type 2 diabetes Five distinct types of diabetes, not just two, suggests study (Source: OnMedica Latest News)
Source: OnMedica Latest News - April 18, 2018 Category: UK Health Source Type: news

MitoCPR--A surveillance pathway that protects mitochondria in response to protein import stress
Mitochondrial functions are essential for cell viability and rely on protein import into the organelle. Various disease and stress conditions can lead to mitochondrial import defects. We found that inhibition of mitochondrial import in budding yeast activated a surveillance mechanism, mitoCPR, that improved mitochondrial import and protected mitochondria during import stress. mitoCPR induced expression of Cis1, which associated with the mitochondrial translocase to reduce the accumulation of mitochondrial precursor proteins at the mitochondrial translocase. Clearance of precursor proteins depended on the Cis1-interacting A...
Source: ScienceNOW - April 12, 2018 Category: Science Authors: Weidberg, H., Amon, A. Tags: Cell Biology, Molecular Biology, Online Only r-articles Source Type: news

Scientists find excess mitochondrial iron, Huntington's disease link
(University of Wyoming) The research identifying a pathway for Huntington's disease helps lay the foundation for developing drug therapies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 11, 2018 Category: International Medicine & Public Health Source Type: news

In a severe childhood neurodegeneration, novel mechanism found
(Children's Hospital of Philadelphia) Neurology researchers investigating a rare but devastating neurological regression in infants have discovered the cause: gene mutations that severely disrupt crucial functions in mitochondria, the energy-producing structures within cells. The specific disease mechanism, in which mutations disrupt a critical mitochondrial enzyme, has not previously been implicated in a human disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 22, 2018 Category: International Medicine & Public Health Source Type: news

Intravenous arginine benefits children after acute metabolic strokes
(Children's Hospital of Philadelphia) Children with mitochondrial diseases who suffered acute metabolic strokes benefited from rapid intravenous treatment with the amino acid arginine, experiencing no side effects from the treatment. The diseases were caused by a range of different genetic disorders. In half of the stroke episodes, patients showed clinical improvements in symptoms such as seizures and partial paralysis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 9, 2018 Category: International Medicine & Public Health Source Type: news

Medical News Today: Parkinson's disease: Why do brain cells die?
A new study has shown that a mitochondrial molecule called cardiolipin helps to correctly fold alpha-synuclein protein, whose incorrectly folded forms are found in Lewy bodies. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 28, 2018 Category: Consumer Health News Tags: Parkinson's Disease Source Type: news

Parkinson's disease: Why do brain cells die?
A new study has shown that a mitochondrial molecule called cardiolipin helps to correctly fold alpha-synuclein protein, whose incorrectly folded forms are found in Lewy bodies. (Source: Parkinson's Disease News From Medical News Today)
Source: Parkinson's Disease News From Medical News Today - February 28, 2018 Category: Neurology Tags: Parkinson's Disease Source Type: news

Spermidine in health and disease
Interventions that delay aging and protect from age-associated disease are slowly approaching clinical implementation. Such interventions include caloric restriction mimetics, which are defined as agents that mimic the beneficial effects of dietary restriction while limiting its detrimental effects. One such agent, the natural polyamine spermidine, has prominent cardioprotective and neuroprotective effects and stimulates anticancer immunosurveillance in rodent models. Moreover, dietary polyamine uptake correlates with reduced cardiovascular and cancer-related mortality in human epidemiological studies. Spermidine preserves...
Source: ScienceNOW - January 25, 2018 Category: Science Authors: Madeo, F., Eisenberg, T., Pietrocola, F., Kroemer, G. Tags: Cell Biology, Medicine, Diseases, Online Only review Source Type: news

Medical News Today: Parkinson's: How a 'bad' enzyme might protect the brain
Reduced levels of a mitochondrial enzyme were previously thought to destroy neurons in Parkinson's disease. The opposite may, in fact, be the case. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 17, 2018 Category: Consumer Health News Tags: Parkinson's Disease Source Type: news

Parkinson's: How a 'bad' enzyme might protect the brain
Reduced levels of a mitochondrial enzyme were previously thought to destroy neurons in Parkinson's disease. The opposite may, in fact, be the case. (Source: Parkinson's Disease News From Medical News Today)
Source: Parkinson's Disease News From Medical News Today - January 17, 2018 Category: Neurology Tags: Parkinson's Disease Source Type: news

How incurable mitochondrial diseases strike previously unaffected families
(Medical Research Council) Researchers have shown for the first time how children can inherit a severe -- potentially fatal -- mitochondrial disease from a healthy mother. The study, led by researchers from the MRC Mitochondrial Biology Unit at the University of Cambridge, reveals that healthy people harbor mutations in their mitochondrial DNA and explains how cases of severe mitochondrial disease can appear unexpectedly in previously unaffected families. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 15, 2018 Category: International Medicine & Public Health Source Type: news

Can vitamins and dietary supplements benefit patients with mitochondrial disease?
(Children's Hospital of Philadelphia) Defects in mitochondria, the tiny structures that power cells by functioning as biological batteries, cause an array of complex disorders that can affect any and all organs and systems. In the absence of validated, effective drug treatments, patients with mitochondrial disease often take a variety of vitamins and supplements, substances that are largely unstandardized, unregulated, and unproven. Experts in the field are calling for systematic studies to evaluate nutritional interventions. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 10, 2018 Category: International Medicine & Public Health Source Type: news

New brainstem changes identified in Parkinson's disease
(Newcastle University) A pioneering study has found that patients with Parkinson's disease have more errors in the mitochondrial DNA within the brainstem, leading to increased cell death in that area. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 4, 2018 Category: International Medicine & Public Health Source Type: news

A New Form of This Miracle Nutrient Is 8 Times More Powerful …
CoQ10 has made the mainstream. You can find it everywhere. But the type of CoQ10 I want to tell you about has been completely ignored. That’s too bad, because this new form is 8 times better at getting into your blood and staying there. And that’s where it has its miracle-like anti-aging effects. This new form of CoQ10 may give you the opportunity to live disease-free for the rest of your life. Today, I’ll show you how this new “reduced” form of CoQ10 gives you greater power to prevent and reverse disease. You’ll also discover that it ramps up your energy levels and slows your aging proc...
Source: Al Sears, MD Natural Remedies - January 3, 2018 Category: Complementary Medicine Authors: Francisco Cabrera Tags: Nutrition antioxidants CoQ10 ubiquinol Source Type: news