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Upcoming Mesothelioma Symposium Filled with Hope
Discussions About Immunotherapy for Mesothelioma Cameron also will speak about engineering mesenchymal stem cells for immunotherapy. Clare Cameron, who is the executive director of the Pacific Mesothelioma Center (PMC) and not related to Dr. Robert Cameron, will talk about resources for research. Lein Hua-Feng, a nurse practitioner at PMC, will discuss the benefits of caregiver support groups. “The symposium will provide an unrivaled opportunity for both the medically savvy and general public, including mesothelioma patients,” Clare Cameron said. “You’ll hear about the most promising medical advance...
Source: Asbestos and Mesothelioma News - August 29, 2017 Category: Environmental Health Authors: Matt Mauney Tags: 7th annual International Symposium on Mesothelioma Angiogenesis Inhibition and Chemotherapy Arti Shukia Banaras Hindu University bap1 Center at the University Hospital of Siena clare cameron Dr. Anna Nowak Dr. Brian Cunniff Dr. David Sch Source Type: news

Stop Marketing Mitochondrial Procedure, FDA Tells Physician Stop Marketing Mitochondrial Procedure, FDA Tells Physician
Dr John Zhang's modification of a human embryo to prevent mitochondrial disease, also known as the'three-person baby'technique, has run afoul of the FDA because of congressional action in 2015.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 9, 2017 Category: Consumer Health News Tags: Pharmacist News Source Type: news

Doctor told to stop marketing 3-person baby technique
Dr John Zhang made headlines last September after helping a couple with mitochondrial disease to deliver a disease-free child, by inserting their DNA into the egg of a donor. (Source: the Mail online | Health)
Source: the Mail online | Health - August 7, 2017 Category: Consumer Health News Source Type: news

Family fights to save boy with Charlie Gard-like disease
Four-month-old Russell Cruzan III, known as Bubby, from Michigan, has a rare mitochondrial disorder. It is the same one that killed British baby Charlie Gard on Friday, but is progressing slower. (Source: the Mail online | Health)
Source: the Mail online | Health - August 2, 2017 Category: Consumer Health News Source Type: news

Patient Reps: Bringing the voice of patients to FDA
By: Jack Kalavritinos At FDA we never lose sight of the fact that the work we do in evaluating and approving new medical products is done to benefit patients. Increasingly, that means taking into account the views and expertise of patients and their caregivers, because they provide a unique voice and perspective and know best what they are living with on a day-to-day basis. Earlier this month, for instance, we announced the creation of the first advisory committee made up solely of patients and caregivers, who will provide advice on complex issues related to medical devices. Another way we incorporate the patient viewpoint...
Source: Mass Device - July 31, 2017 Category: Medical Devices Authors: Danielle Kirsh Tags: Blog FDA Voice Source Type: news

Newton biotech says drug targeting cell's energy center shows promise
A Newton biotech says it has moved one step closer to developing the first treatment for rare genetic diseases of the mitochondria — the powerhouses of the cell that create 90 percent of the human body’s energy. Privately held Stealth BioTherapeutics on Thursday unveiled what it characterized as positive data from a Phase 2 study of its potential treatment for "mitochondrial myopathy," muscle weakness caused by a broad cla ss of diseases. The 50-employee company, which has raised around $200… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - June 29, 2017 Category: Pharmaceuticals Authors: Max Stendahl Source Type: news

Mitochondrial disease has a disproportionate healthcare burden in US
(Children's Hospital of Philadelphia) Mitochondrial diseases are a diverse group of disorders caused by mutated genes that impair energy production in a patient's cells, often with severe effects. Patients with these diseases incur high medical costs for hospitalization, and suffer higher-than-typical rates of comorbid diseases and in-hospital mortality. Researchers who analyzed those costs say their findings underscore the importance of developing preventive strategies and therapies for these illnesses. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 28, 2017 Category: International Medicine & Public Health Source Type: news

Mitoconix Bio Raises $20 Million in Series A Funding to Develop Neurodegenerative Disease Therapies
Proceeds will be used to advance the Company's lead product through preclinical and clinical development and expand its therapeutic pipeline for treating neurodegenerative disorders by improving mitochondrial function NESS ZIONA, Israel, June 27, 2017 -... Biopharmaceuticals, Neurology, Venture Capital Mitoconix Bio, Huntington's disease (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - June 27, 2017 Category: Pharmaceuticals Source Type: news

How to Protect Your Brain Against Alzheimer ’s
A few weeks ago, Big Pharma giant Merck canceled the clinical trial for its latest “promising” Alzheimer’s drug. Why? It was a total flop. The same thing happened four months ago with a drug that Eli Lilly was testing. The reality is that more than 99% of Alzheimer’s drugs fail in development. This proves that mainstream medicine has no clue what causes this brain-wasting condition. So what’s really going on? A big part of the problem is in the very air we breathe. And the closer you live to a major roadway or urban center, the worse it is&hel...
Source: Al Sears, MD Natural Remedies - June 22, 2017 Category: Complementary Medicine Authors: Cathy Card Tags: Brain Health Nutrition Alzheimer's cognitive decline pollution toxins Source Type: news

6 Ways To Survive Summer Travel With A Chronic Illness
Two summers ago, I planned the family road trip of a lifetime. I bought an inexpensive and used camping trailer, loaded it up with everything from toiletries to food, and set out on a 21-day road trip through six western states. I planned our route meticulously, lining up activities and stops along the way, but what got lost in the shuffle was my own chronic health needs. I assumed I would be able to stretch out my regular medical infusions to allow for my travel or refill my prescriptions on-the-go, but I quickly learned how wrong I was. I spent way too much of my vacation tackling my medical challenges instead of enjoyin...
Source: Healthy Living - The Huffington Post - June 14, 2017 Category: Consumer Health News Source Type: news

Aberrant telomere length and mitochondrial DNA copy number in suicide completers - Otsuka I, Izumi T, Boku S, Kimura A, Zhang Y, Mouri K, Okazaki S, Shiroiwa K, Takahashi M, Ueno Y, Shirakawa O, Sora I, Hishimoto A.
Short telomere length (TL) occurs in individuals under psychological stress, and with various psychiatric diseases. Recent studies have also reported mitochondrial DNA copy number (mtDNAcn) alterations under several neuropsychiatric conditions. However, no... (Source: SafetyLit)
Source: SafetyLit - June 14, 2017 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Potential therapeutic target for Parkinson's disease
Investigations by scientists in Japan illustrate how the loss of a key mitochondrial protein facilitates the progression of Parkinson's disease. The findings are published in Nature Communications. (Source: Parkinson's Disease News From Medical News Today)
Source: Parkinson's Disease News From Medical News Today - June 13, 2017 Category: Neurology Tags: Parkinson's Disease Source Type: news

Neurodegenerative disease mechanism and potential drug identified
(University of California - Davis) Two new, UC Davis-led studies of neurodegenerative diseases linked to mitochondrial defects offer hope for developing a new biomarker for research and diagnostics, and a drug for treating such diseases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 6, 2017 Category: International Medicine & Public Health Source Type: news

Disease Awareness Months Work, Even If You Don't Wear The Ribbon
June ​is the month for more than 10 disease-related awareness campaigns, including Myasthenia Gravis Awareness Month, National Congenital Cytomegalovirus Awareness Month and National Scleroderma Awareness Month. It also hosts a handful of awareness weeks and days, ranging from Helen Keller Deaf-Blind Awareness Week to World Sickle Cell Day. June’s awareness list is shorter than most, but every month is full of diseases and disorders to take note of. You probably haven’t heard of half of them, and you’re not alone. So what’s the point of an awareness day, week or month? To understand the chall...
Source: Healthy Living - The Huffington Post - June 2, 2017 Category: Consumer Health News Source Type: news

Parents of sick baby say therapy in US is son's 'last hope' of survival
Chris Gard and Connie Yates want appeal court judges to overrule earlier decision for hospital to withdraw Charlie ’s life supportA couple who want to take their sick baby son abroad for treatment have asked three court of appeal judges not to take away their “only remaining hope” for his survival.Chris Gard and Connie Yates want permission to take nine-month-old Charlie, who has a form of mitochondrial disease that causes brain damage and muscle problems, to the US for a therapy trial.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - May 23, 2017 Category: Science Authors: Press Association Tags: Court of appeal UK news Neuroscience US healthcare NHS Hospitals Genetics Biology US news Law London Source Type: news

Family history of Alzheimer's may alter metabolic gene that increases risk for disease
(Iowa State University) A new Iowa State University study may have identified the link that explains years of conflicting research over a mitochondrial gene and the risk for Alzheimer's disease. Researchers found a dramatic difference in the gene's impact on memory, general cognitive function and risk based on a family history of Alzheimer's disease and the length of a specific section of the gene. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 23, 2017 Category: International Medicine & Public Health Source Type: news

Low oxygen reverses mitochondrial disease in mice
Hypoxia reverses brain damage caused by mitochondrial dysfunction, a team finds. The approach might one day point to new therapies for people with Leigh syndrome and other mitochondrial disorders. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 8, 2017 Category: Science Source Type: news

KU Med researchers test new approach to Alzheimer's
The Kansas City Area Life Sciences Institute Inc. re-launched its Collaborate2Cure series on Monday, with two speakers sharing new approaches to treating Alzheimer's disease. In the coming months, area researchers will present on the topic of mitochondrial dysfunction, with the potential to land a $50,000 grant for collaborative research. The free weekly seminars take place 4 to 6 p.m. every Monday at the University of Kansas Medical Center's Research Institute in Fairway. Registration and archived… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - May 2, 2017 Category: Pharmaceuticals Authors: Elise Reuter Source Type: news

KU Med researchers test new approach to Alzheimer's
The Kansas City Area Life Sciences Institute Inc. re-launched its Collaborate2Cure series on Monday, with two speakers sharing new approaches to treating Alzheimer's disease. In the coming months, area researchers will present on the topic of mitochondrial dysfunction, with the potential to land a $50,000 grant for collaborative research. The free weekly seminars take place 4 to 6 p.m. every Monday at the University of Kansas Medical Center's Research Institute in Fairway. Registration and archived… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 2, 2017 Category: Biotechnology Authors: Elise Reuter Source Type: news

Unravelling the mystery of DNA attacks in cells' powerhouse could pave way for new cancer treatments
A five-year study has found the mechanism responsible for repairing damage to mitochondrial DNA. This discovery could pave the way for new treatments for cancer and neurodegenerative diseases, say the researchers. This research may also have important implications for clinical advances in so called ‘three-parent baby’ mitochondrial donation. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 28, 2017 Category: Science Source Type: news

Vital role for mitochondrial calcium exchange in heart function
Scientists have long thought that calcium transport into mitochondria is a key signal linking cardiac workload, or how hard the heart pumps, with energy production. Now, in a major breakthrough, researchers show that the exit of calcium from mitochondria serves a critical role in heart function and may represent a powerful therapeutic approach to limit heart disease. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 26, 2017 Category: Science Source Type: news

4 Ways Researchers Are Pushing The Boundaries Of Making Babies
Infertility treatment is more common than ever, thanks to technology.  More than 70,000 babies were born through in-vitro fertilization in 2014, according to the latest Centers for Disease Control and Prevention data. That’s an increase of nearly 10,000 babies, compared with five years earlier. Men and women are increasingly likely to seek medical help for reasons that include reduced stigma and more employers offering coverage for IVF. But one big reason for the trend is clear: Fertility doctors are getting better at making babies. “Science is moving at a pace that’s very different th...
Source: Science - The Huffington Post - April 25, 2017 Category: Science Source Type: news

4 Ways Researchers Are Pushing The Boundaries Of Making Babies
Infertility treatment is more common than ever, thanks to technology.  More than 70,000 babies were born through in-vitro fertilization in 2014, according to the latest Centers for Disease Control and Prevention data. That’s an increase of nearly 10,000 babies, compared with five years earlier. Men and women are increasingly likely to seek medical help for reasons that include reduced stigma and more employers offering coverage for IVF. But one big reason for the trend is clear: Fertility doctors are getting better at making babies. “Science is moving at a pace that’s very different th...
Source: Healthy Living - The Huffington Post - April 25, 2017 Category: Consumer Health News Source Type: news

Researchers discover mitochondrial “circuit breaker” that protects heart from damage
Two newly identified mechanisms may lead to better understanding of disease, new treatments. (Source: National Institutes of Health (NIH) News Releases)
Source: National Institutes of Health (NIH) News Releases - April 18, 2017 Category: American Health Source Type: news

Affection of the respiratory muscles in combined complex I and IV deficiency
We present a 45 years old male MID due to a combined complex I+IV defect of the respiratory chain. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 14, 2017 Category: Infectious Diseases Source Type: news

What Are the Clinical Symptoms Associated with Friedreich Ataxia?
Discussion Friedreich ataxia (FRDA) was first extensively described in a series of papers from 1863-1877 by Nikolaus Friedreich at the University of Heidelberg, Germany. In 1996 the genetic mutation was described. It is an autosomal recessively inherited, homologous expansion of the GAA repeat in intron 1 of the frataxin gene on chromosome 9q13. It causes a transcription error leading to a decrease in frataxin which is a mitochondrial protein involved in iron metabolism and other cell functions. Frataxin is seen mainly in the central and peripheral nervous systems, heart, pancreas and skeleton. Frataxin is produced but in ...
Source: PediatricEducation.org - April 10, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Neonatal Lactic Acidosis: A Diagnostic and Therapeutic Approach
Neonatal lactate elevation is a relatively common finding with heterogeneous causes. Understanding the reason for the lactate elevation is critical to determining the prognosis and treatment options. Lactate can be elevated spuriously, secondary to a number of common neonatal conditions or intermediary inborn errors of metabolism, or as a primary finding in mitochondrial diseases. The extent of the lactate elevation, clinical context, and simple metabolic tests can help differentiate among these causes. (Source: NeoReviews recent issues)
Source: NeoReviews recent issues - March 31, 2017 Category: Pediatrics Authors: Ganetzky, R. D., Cuddapah, S. R. Tags: Pediatric Drug Labeling Update Articles Source Type: news

Researchers identify potential treatment for type of muscle and brain degenerative disease
In fruit flies modeled with IBMPFD disease, mitochondria (red circles) are severely disrupted. Treatment of VCP inhibitors in these diseased flies reversed  mitochondrial damage (green circles). FINDINGSUCLA researchers have discovered the molecular basis of, and identified potential treatment for, an incurable disease known as inclusion body myopathy, Paget disease with frontotemporal dementia, or IBMPFD. Using both genetically engineered fruit flies that have the fly equivalent of the disease gene as well as cells from people with IBMPFD, the researchers discovered how mutations carried by those with IBMPFD cau...
Source: UCLA Newsroom: Health Sciences - March 21, 2017 Category: Universities & Medical Training Source Type: news

Controlling energy production by calcium is an organ-specific affair
Researchers have shown that the composition of the mitochondrial calcium portal (the protein that regulates when and how much calcium enters) is different depending on the organ in the body, and this difference allows mitochondria to tune their energy output by decoding a pattern of amplitude and/or frequency of calcium oscillations inside a cell. The results could shed light on our basic understanding of organ health and disease. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 7, 2017 Category: Science Source Type: news

Controlling energy production by calcium is an organ-specific affair
(Thomas Jefferson University) Researchers at Thomas Jefferson University have shown that the composition of the mitochondrial calcium portal (the protein that regulates when and how much calcium enters) is different depending on the organ in the body, and this difference allows mitochondria to tune their energy output by decoding a pattern of amplitude and/or frequency of calcium oscillations inside a cell. The results, published March 7 in the journal Cell Reports, could shed light on our basic understanding of organ health and disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 7, 2017 Category: Global & Universal Source Type: news

Ellie Challenge puts rare disease in the spotlight
Ellie McGinn, 9, was born with a rare mitochondrial disease. (Source: ABC News: Health)
Source: ABC News: Health - February 28, 2017 Category: Consumer Health News Tags: Health Source Type: news

What Causes Hyperammonemia?
Discussion Reye’s syndrome (RS)is named for Dr. Douglas Reye who along with Drs. G. Morgan and J. Baral described encephalopathy and fatty accumulation and degeneration in children in a 1963 Lancet article. RS usually affects children but can occur at all ages. All organs can be affected but the liver and brain are primarily affected causing liver failure and encephalopathy as toxic metabolites (especially ammonia) accumulate, and intracranial hypertension and cerebral edema occurs. As the ammonia levels begin to rise (> 100 mg/dL) patients lose their appetite, have nausea and emesis and mental status changes whic...
Source: PediatricEducation.org - February 20, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

[Report] Vitamin B3 modulates mitochondrial vulnerability and prevents glaucoma in aged mice
Glaucomas are neurodegenerative diseases that cause vision loss, especially in the elderly. The mechanisms initiating glaucoma and driving neuronal vulnerability during normal aging are unknown. Studying glaucoma-prone mice, we show that mitochondrial abnormalities are an early driver of neuronal dysfunction, occurring before detectable degeneration. Retinal levels of nicotinamide adenine dinucleotide (NAD+, a key molecule in energy and redox metabolism) decrease with age and render aging neurons vulnerable to disease-related insults. Oral administration of the NAD+ precursor nicotinamide (vitamin B3), and/or gene therapy ...
Source: ScienceNOW - February 16, 2017 Category: Science Authors: Pete A. Williams Source Type: news

Mitochondrial lipids as potential targets in early onset Parkinson's disease
A team of researchers led by Patrik Verstreken (VIB-KU Leuven) have identified an underlying mechanism in early onset Parkinson's. (Source: Parkinson's Disease News From Medical News Today)
Source: Parkinson's Disease News From Medical News Today - February 14, 2017 Category: Neurology Tags: Parkinson's Disease Source Type: news

Mitochondrial lipids as potential targets in early onset Parkinson's disease
A team of researchers has identified an underlying mechanism in early onset Parkinson ’s. Using flies, mice and patient cells, the team focused on cardiolipin, a fat unique to cells’ mitochondria, organelles that produce energy. They demonstrated that reducing the effects of the protein FASN influences the mitochondria, leading to increased cardiolipin levels and reduced Parkinso n’s symptoms. These results could pave the way to therapies for Parkinson’s disease that target lipids. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 10, 2017 Category: Science Source Type: news

Mitochondrial lipids as potential targets in early onset Parkinson's disease
(VIB (the Flanders Institute for Biotechnology)) A team of researchers led by Patrik Verstreken have identified an underlying mechanism in early onset Parkinson's. Using flies, mice and patient cells, the team focused on cardiolipin, a fat unique to cells' mitochondria, organelles that produce energy. They demonstrated that reducing the effects of the protein FASN influences the mitochondria, leading to increased cardiolipin levels and reduced Parkinson's symptoms. These results could pave the way to therapies for Parkinson's disease that target lipids. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 10, 2017 Category: Global & Universal Source Type: news

Parkinson's disease: Could the answer lie in mitochondria of dopamine cells?
Researchers find dopamine cells in Parkinson's disease brains do not protect against aging-related mitochondrial DNA damage as well as in healthy brains. (Source: Parkinson's Disease News From Medical News Today)
Source: Parkinson's Disease News From Medical News Today - January 24, 2017 Category: Neurology Tags: Parkinson's Disease Source Type: news

Medical News Today: Parkinson's disease: Could the answer lie in mitochondria of dopamine cells?
Researchers find dopamine cells in Parkinson's disease brains do not protect against aging-related mitochondrial DNA damage as well as in healthy brains. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 24, 2017 Category: Consumer Health News Tags: Parkinson's Disease Source Type: news

Mitochondrial roles of the psychiatric disease risk factor DISC1 - Norkett R, Modi S, Kittler JT.
Ion transport during neuronal signalling utilizes the majority of the brain's energy supply. Mitochondria are key sites for energy provision through ATP synthesis and play other important roles including calcium buffering. Thus, tightly regulated distribut... (Source: SafetyLit)
Source: SafetyLit - January 21, 2017 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Newcastle boy baffles doctors by recovering from an 'incurable disease'
Taylor Davison, from Newcastle, was believed to suffer from mitochondrial disease. But testing revealed he was actually plagued with a curable condition that has identical symptoms. (Source: the Mail online | Health)
Source: the Mail online | Health - January 9, 2017 Category: Consumer Health News Source Type: news

Mitochondria in complex psychiatric disorders: Lessons from mouse models of 22q11.2 deletion syndrome: Hemizygous deletion of several mitochondrial genes in the 22q11.2 genomic region can lead to symptoms associated with neuropsychiatric disease - Devaraju P, Zakharenko SS.
Mitochondrial ATP synthesis, calcium buffering, and trafficking affect neuronal function and survival. Several genes implicated in mitochondrial functions map within the genomic region associated with 22q11.2 deletion syndrome (22q11DS), which is a key gen... (Source: SafetyLit)
Source: SafetyLit - January 7, 2017 Category: Global & Universal Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Brave New World: UK Is First To Legalize Three-Parent Babies
It’s now legal in Britain to create a three-parent baby using healthy DNA from a donor to fix debilitating genetic problems. U.K. fertility clinic regulator Human Fertilization and Embryology Authority (HFEA) has approved the “cautious use” of the technique, developed by British scientists, to replace an egg’s defective mitochondrial DNA with healthy mitochondrial DNA from another female donor to prevent the child from suffering from genetic flaws.  We have permitted the cautious use of mitochondrial donation in treatment, following advice from scientific experts https://t.co/2xKOcriIHO—...
Source: Science - The Huffington Post - December 16, 2016 Category: Science Source Type: news

£8m for ground-breaking mitochondrial donation clinical trial
NHS England has announced it will make up to £8m available over five years to fund the treatment costs of a five year clinical trial of mitochondrial donation – a form of IVF in which the future baby’s mitochondrial DNA comes from a donor egg, to avoid passing on inherited mitochondrial diseases. (Source: NHS Networks)
Source: NHS Networks - December 15, 2016 Category: UK Health Source Type: news

[This Week in Science] A mitochondrial target for slowing PD
Author: Orla M. Smith (Source: ScienceNOW)
Source: ScienceNOW - December 8, 2016 Category: Science Authors: Orla M. Smith Tags: Parkinson's Disease Source Type: news

New methods to combat cell damage that accumulates with age
Researchers from UCLA and Caltech have made discoveries that might help slow and potentially reverse the process of aging in cells.They generated new methods that allow identification of factors that selectively remove damaged mitochondrial DNA, which will affect the process of aging at the cellular level. Aging is, in part, due to changes in mitochondria, the energy-providing powerhouses of the cell.Mitochondria contain their own DNA, and the accumulation of mutations of mitochondrial DNA throughout a lifetime contributes to aging.There are two strategies for combating age-related diseases. One way is to fight the individ...
Source: UCLA Newsroom: Health Sciences - November 23, 2016 Category: Universities & Medical Training Source Type: news

Power outage in the brain may be source of Alzheimer's
In a new study, researchers investigate the role of mitochondria in Alzheimer's disease pathology. Mitochondria act as energy centers for cells and are of central importance in health and disease. The study builds on earlier work suggesting gene mutations affecting mitochondrial function may be critical in the development of the disease. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - November 9, 2016 Category: Science Source Type: news

Power outage in the brain may be source of Alzheimer's
(Arizona State University) In new research appearing in the journal Alzheimer's and Dementia, Diego Mastroeni, Paul Coleman and their colleagues at the ASU-Banner Neurodegenerative Disease Research Center (NDRC) and the Biodesign Center for Bioenergetics investigate the role of mitochondria in Alzheimer's disease pathology. Mitochondria act as energy centers for cells and are of central importance in health and disease. The study builds on earlier work suggesting gene mutations affecting mitochondrial function may be critical in the development -- and pitiless progression -- of the disease. (Source: EurekAlert! - Social an...
Source: EurekAlert! - Social and Behavioral Science - November 4, 2016 Category: Global & Universal Source Type: news

[Research Article] A nuclease that mediates cell death induced by DNA damage and poly(ADP-ribose) polymerase-1
Inhibition or genetic deletion of poly(ADP-ribose) (PAR) polymerase-1 (PARP-1) is protective against toxic insults in many organ systems. The molecular mechanisms underlying PARP-1–dependent cell death involve release of mitochondrial apoptosis-inducing factor (AIF) and its translocation to the nucleus, which results in chromatinolysis. We identified macrophage migration inhibitory factor (MIF) as a PARP-1–dependent AIF-associated nuclease (PAAN). AIF was required for recruitment of MIF to the nucleus, where MIF cleaves genomic DNA into large fragments. Depletion of MIF, disruption of the AIF-MIF interaction, o...
Source: ScienceNOW - October 6, 2016 Category: Science Authors: Yingfei Wang Source Type: news

5 Things to Know About First Baby Born With DNA From Three People 5 Things to Know About First Baby Born With DNA From Three People
Mitochondrial manipulation technology allowed a woman to give birth to a baby born without her mitochondrial disease. Here's what you need to know about this medical breakthrough.Medscape Ob/Gyn (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 4, 2016 Category: Consumer Health News Tags: Ob/Gyn & Women ' s Health Article Source Type: news

5 Things to Know About Baby Born With DNA From Three People 5 Things to Know About Baby Born With DNA From Three People
Mitochondrial manipulation technology allowed a woman to give birth to a baby born without her mitochondrial disease. Here's what you need to know about this medical breakthrough.Medscape Ob/Gyn (Source: Medscape Nurses Headlines)
Source: Medscape Nurses Headlines - October 4, 2016 Category: Nursing Tags: Ob/Gyn & Women ' s Health Article Source Type: news