Long Covid causes changes in body that make exercise debilitating – study
Experts say severe muscle damage, mitochondrial problems and microclots may explain impact of working outMany people with long Covid feel tired, unwell and in pain for lengthy periods after exercise, and researchers say they now know why.Experts say they have evidence that biological changes are to blame, such as severe muscle damage, mitochondrial problems and the presence of microclots in the body.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - January 4, 2024 Category: Science Authors: Nicola Davis Science correspondent Tags: Coronavirus Infectious diseases Medical research World news Microbiology Science Netherlands Source Type: news

Building community to advance metabolic science
A new Yale program will allow investigators to tackle questions relating to how mitochondrial function and regulation impacts metabolism and disease. (Source: Yale Science and Health News)
Source: Yale Science and Health News - January 2, 2024 Category: Universities & Medical Training Source Type: news

Newly discovered genetic mutation protects against Parkinson & #039;s disease
A previously unidentified genetic mutation in a small protein provides significant protection against Parkinson's disease and offers a new direction for exploring potential treatments, according to a new USC Leonard Davis School of Gerontology study. The variant, located in a mitochondrial microprotein dubbed SHLP2, was found to be highly protective against Parkinson’s disease; individuals with this mutation are half as likely to develop the disease as those who do not carry it. (Source: World Pharma News)
Source: World Pharma News - January 2, 2024 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

What to Know About Heart Failure When You Have Diabetes
In June of 2022, a report from the American Diabetes Association highlighted heart failure as “an underappreciated complication of diabetes.” According to that report, up to 22% of people with diabetes will develop heart failure, and the incidence of heart failure within the diabetes community is increasing. “Heart failure is the most prevalent cardiovascular complication in people with diabetes,” says Dr. Rodica Pop-Busui, a professor of diabetes at the University of Michigan and president of medicine and science at the American Diabetes Association. “In the U.S. alone there are 37 million...
Source: TIME: Health - December 29, 2023 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized healthscienceclimate Source Type: news

Race to find a cure for heartbreaking disease which slowly killed baby Indi Gregory
Indi Gregory's heartbreaking battle with the disease has shone fresh light on mitochondrial disease, a catch-all term for genetic disorders caused by mutations in mitochondria. (Source: the Mail online | Health)
Source: the Mail online | Health - November 13, 2023 Category: Consumer Health News Source Type: news

A New Clue Into the Cause, Spread of Parkinson's Disease? A New Clue Into the Cause, Spread of Parkinson's Disease?
Damaged mitochondrial DNA initiates and spreads Parkinson ' s disease pathology, potentially opening new avenues for early diagnosis, researchers say.Medscape Medical News (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - October 6, 2023 Category: Pathology Tags: Neurology & Neurosurgery News Source Type: news

AbbVie Exercises Exclusive Right to Acquire Mitokinin, Further Strengthening Neuroscience Pipeline
Mitokinin's lead compound, a selective PINK1 activator, is designed to address mitochondrial dysfunction, which plays a key role in the pathogenesis of Parkinson's disease Activation of PINK1 remediates mitochondrial damage and restores mitochondrial fu... Biopharmaceuticals, Neurology, Mergers & Acquisitions AbbVie, Mitokinin, Parkinson's Disease (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - October 5, 2023 Category: Pharmaceuticals Source Type: news

UMDF, MitoAction Help Lift Up Patient Voices on FDA Listening Session for Pyruvate Dehydrogenase Complex Deficiency (PDCD)
The United Mitochondrial Disease Foundation and MitoAction share their reactions to a September 8, 2023 listening session with the U.S. Food and Drug Administration regarding Pyruvate Dehydrogenase Complex Deficiency (PDCD). PITTSBURGH, Sept. 15, 2023 /PRNewswire-PRWeb/ -- Today, patient... (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - September 15, 2023 Category: Pharmaceuticals Tags: FDA NPT Source Type: news

New blood test for Parkinson ’s could help doctors to detect it earlier
Researchers have developed a PCR assay to detect higher levels of mitochondrial DNA damage in blood cells. A new blood test could detect Parkinson’s disease earlier and help to determine who might benefit from specific treatments. Parkinson’s is a progressive brain condition that causes shaking,…#pcr #lauriesanders #dukeuniversitys #sanders (Source: Reuters: Health)
Source: Reuters: Health - September 1, 2023 Category: Consumer Health News Source Type: news

A blood test for Parkinson ’s disease?
Parkinson’s disease, a brain disorder that gradually leads to difficulty moving, tremors, and usually dementia by the end, is often difficult to diagnose early in its yearslong progression. That makes testing experimental treatments challenging and slows people from getting existing drugs, which can’t stop the ongoing death of brain cells but temporarily improve many of the resulting symptoms. Now, a study using rodents and tissue from diagnosed Parkinson’s patients suggests DNA damage spotted in blood samples offers a simple way to diagnose the disease early. Although the potential test needs to be validated i...
Source: ScienceNOW - August 30, 2023 Category: Science Source Type: news

Parkinson ’ s Patients Get More Mobility And Better Balance With Whole Body Vibration Therapy
I’ve always believed that with a little coaxing, your body can self-heal – and the same is true for your brain. Conventional doctors will never tell you this. For them, being a physician means managing symptoms with Big Pharma meds. But for years, I’ve been helping patients recover using dietary changes, lasers, stem cells, and hyperbaric oxygen (HBOT). These therapies help your body heal itself. No Big Pharma drug can do this. But I recently began researching another natural therapy – called Whole Body Vibration, or WBV – that can help Parkinson’s patients regain their mobility and balance. WBV isn’t new. It...
Source: Al Sears, MD Natural Remedies - August 28, 2023 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Health Natural Cures Source Type: news

Long COVID: Mitochondria, the Big Miss, and Hope Long COVID: Mitochondria, the Big Miss, and Hope
This week there was news on Long COVID: emergence of data to support mitochondrial dysfunction as a potential cause, and learning how $1.15 billion to the NIH RECOVER initiative has largely been wasted.Medscape Medical News (Source: Medscape Infectious Diseases Headlines)
Source: Medscape Infectious Diseases Headlines - August 15, 2023 Category: Infectious Diseases Tags: Infectious Diseases News Source Type: news

Epigenetic embedding of childhood adversity: mitochondrial metabolism and neurobiology of stress-related CNS diseases - Bigio B, Sagi Y, Barnhill O, Dobbin J, El Shahawy O, de Angelis P, Nasca C.
This invited article ad memoriam of Bruce McEwen discusses emerging epigenetic mechanisms underlying the long and winding road from adverse childhood experiences to adult physiology and brain functions. The conceptual framework that we pursue suggest multi... (Source: SafetyLit)
Source: SafetyLit - August 14, 2023 Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news

Wake Forest University School of Medicine study examines tech to reverse damage to kidneys and kidney cells
According to the National Kidney Foundation, more than 100,000 Americans are waiting for a kidney transplant, and the demand for donated kidneys far exceeds the supply. In fact, only 25,498 kidney transplants were performed in 2022, and kidney disease impacts 37 million people in the U.S. But a new preclinical study, led by scientists at Wake Forest University School of Medicine, shows that a new technology called mitochondrial transplantation holds promise as a potential therapy that could change … (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - August 14, 2023 Category: Pharmaceuticals Authors: Atrium Health Wake Forest Baptist Source Type: news

What is the Diagnostic Yield for Genetic Testing of Children with Neurodevelopmental Delays?
Discussion Children having significant neurodevelopmental disabilities are common with 17% of 3-17 year olds children having some type of such disability. Many are recommended to have genetic testing. Three main reasons for testing are determining the etiology, potential availability of targeted treatment or intervention, and determination of recurrence risk. But there are other pros and some cons to genetic testing which include: Pros Diagnosis is determined Improved understanding of diagnosis, natural history and prognosis for patient and family including decreased anxiety/guilt “Can end the diagnostic odyssey...
Source: PediatricEducation.org - July 10, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news