PET/MRI reveals sex differences in patients with autism
PET/MRI shows that young women with autism spectrum disorder (ASD) have increased brain metabolism associated with translocator protein (TSPO), a group from Harvard University in Boston has reported.
In a pilot study, the researchers showed that women with autism have higher uptake of carbon-11 (C-11) PBR28 radiotracer -- which binds to TSPO -- on brain PET/MRI than those without the condition. The finding adds to current scarce knowledge about molecular markers in these patients, noted lead author Chieh-En Jane Tseng, PhD, and colleagues.
“Over 90% of neuroimaging studies in ASD in the last 20 years only studied males...
Source: AuntMinnie.com Headlines - April 18, 2024 Category: Radiology Authors: Will Morton Tags: Molecular Imaging Source Type: news
We thought Minecraft was making our son ill - but the truth was much worse: Parents' agony as nine-year-old boy is told his 'next seizure could be his last' after being diagnosed with one of the world's rarest disease
William Howard, nine, was told by doctors his initial symptom, a twitch in his right leg, could be down to stress from playing Minecraft. But investigations show he has mitochondrial disease. (Source: the Mail online | Health)
Source: the Mail online | Health - April 8, 2024 Category: Consumer Health News Source Type: news
Stealth Biotherapeutics Announces FDA Acceptance of New Drug Application for Elamipretide for the Treatment of Barth Syndrome
NEEDHAM, Mass., April 8, 2024 /PRNewswire/— Stealth BioTherapeutics, a clinical-stage biotechnology company focused on the discovery, development and commercialization of novel therapies for diseases involving mitochondrial dysfunction, today... (Source: Drugs.com - New Drug Applications)
Source: Drugs.com - New Drug Applications - April 8, 2024 Category: Drugs & Pharmacology Source Type: news
Novel biological mechanism discovered that could lead to new treatments for neurological disorders, cancers
The lab of Yongchao C. Ma, PhD, at Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago discovered a fundamental biological mechanism that could lead to new treatments for neurological diseases, such as spinal muscular atrophy (SMA) and autism, as well as different cancers. The study was published in the journal Human Molecular Genetics.
Dr. Ma's team found that chemical modification of RNA (called RNA methylation) regulates mitochondrial function. (Source: World Pharma News)
Source: World Pharma News - April 5, 2024 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news
The United Mitochondrial Disease Foundation Announces Inaugural Venture Philanthropy Investment; The Mito Fund Invests $500k in Pierrepont Therapeutics, Inc.
The United Mitochondrial Disease Foundation's venture philanthropy initiative, The Mito Fund has invested $500,000 in Pierrepont Therapeutics, Inc., a company focusing on treatments for primary mitochondrial and rare diseases, for the development of PTI-501, a proprietary intracellular... (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - April 4, 2024 Category: Pharmaceuticals Tags: NPT VEN Source Type: news
Long Covid causes changes in body that make exercise debilitating – study
Experts say severe muscle damage, mitochondrial problems and microclots may explain impact of working outMany people with long Covid feel tired, unwell and in pain for lengthy periods after exercise, and researchers say they now know why.Experts say they have evidence that biological changes are to blame, such as severe muscle damage, mitochondrial problems and the presence of microclots in the body.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - January 4, 2024 Category: Science Authors: Nicola Davis Science correspondent Tags: Coronavirus Infectious diseases Medical research World news Microbiology Science Netherlands Source Type: news
Building community to advance metabolic science
A new Yale program will allow investigators to tackle questions relating to how mitochondrial function and regulation impacts metabolism and disease. (Source: Yale Science and Health News)
Source: Yale Science and Health News - January 2, 2024 Category: Universities & Medical Training Source Type: news
Newly discovered genetic mutation protects against Parkinson & #039;s disease
A previously unidentified genetic mutation in a small protein provides significant protection against Parkinson's disease and offers a new direction for exploring potential treatments, according to a new USC Leonard Davis School of Gerontology study.
The variant, located in a mitochondrial microprotein dubbed SHLP2, was found to be highly protective against Parkinson’s disease; individuals with this mutation are half as likely to develop the disease as those who do not carry it. (Source: World Pharma News)
Source: World Pharma News - January 2, 2024 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news
What to Know About Heart Failure When You Have Diabetes
In June of 2022, a report from the American Diabetes Association highlighted heart failure as “an underappreciated complication of diabetes.” According to that report, up to 22% of people with diabetes will develop heart failure, and the incidence of heart failure within the diabetes community is increasing.
“Heart failure is the most prevalent cardiovascular complication in people with diabetes,” says Dr. Rodica Pop-Busui, a professor of diabetes at the University of Michigan and president of medicine and science at the American Diabetes Association. “In the U.S. alone there are 37 million...
Source: TIME: Health - December 29, 2023 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized healthscienceclimate Source Type: news
Race to find a cure for heartbreaking disease which slowly killed baby Indi Gregory
Indi Gregory's heartbreaking battle with the disease has shone fresh light on mitochondrial disease, a catch-all term for genetic disorders caused by mutations in mitochondria. (Source: the Mail online | Health)
Source: the Mail online | Health - November 13, 2023 Category: Consumer Health News Source Type: news
A New Clue Into the Cause, Spread of Parkinson's Disease? A New Clue Into the Cause, Spread of Parkinson's Disease?
Damaged mitochondrial DNA initiates and spreads Parkinson ' s disease pathology, potentially opening new avenues for early diagnosis, researchers say.Medscape Medical News (Source: Medscape Pathology Headlines)
Source: Medscape Pathology Headlines - October 6, 2023 Category: Pathology Tags: Neurology & Neurosurgery News Source Type: news
AbbVie Exercises Exclusive Right to Acquire Mitokinin, Further Strengthening Neuroscience Pipeline
Mitokinin's lead compound, a selective PINK1 activator, is designed to address mitochondrial dysfunction, which plays a key role in the pathogenesis of Parkinson's disease
Activation of PINK1 remediates mitochondrial damage and restores mitochondrial fu... Biopharmaceuticals, Neurology, Mergers & Acquisitions AbbVie, Mitokinin, Parkinson's Disease (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - October 5, 2023 Category: Pharmaceuticals Source Type: news
UMDF, MitoAction Help Lift Up Patient Voices on FDA Listening Session for Pyruvate Dehydrogenase Complex Deficiency (PDCD)
The United Mitochondrial Disease Foundation and MitoAction share their reactions to a September 8, 2023 listening session with the U.S. Food and Drug Administration regarding Pyruvate Dehydrogenase Complex Deficiency (PDCD). PITTSBURGH, Sept. 15, 2023 /PRNewswire-PRWeb/ -- Today, patient... (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - September 15, 2023 Category: Pharmaceuticals Tags: FDA NPT Source Type: news
New blood test for Parkinson ’s could help doctors to detect it earlier
Researchers have developed a PCR assay to detect higher levels of mitochondrial DNA damage in blood cells. A new blood test could detect Parkinson’s disease earlier and help to determine who might benefit from specific treatments. Parkinson’s is a progressive brain condition that causes shaking,…#pcr #lauriesanders #dukeuniversitys #sanders (Source: Reuters: Health)
Source: Reuters: Health - September 1, 2023 Category: Consumer Health News Source Type: news
A blood test for Parkinson ’s disease?
Parkinson’s disease, a brain disorder that gradually leads to difficulty moving, tremors, and usually dementia by the end, is often difficult to diagnose early in its yearslong progression. That makes testing experimental treatments challenging and slows people from getting existing drugs, which can’t stop the ongoing death of brain cells but temporarily improve many of the resulting symptoms. Now, a study using rodents and tissue from diagnosed Parkinson’s patients suggests DNA damage spotted in blood samples offers a simple way to diagnose the disease early.
Although the potential test needs to be validated i...
Source: ScienceNOW - August 30, 2023 Category: Science Source Type: news
