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Antioxidants found to be effective in treating mitochondrial disease, preclinical trials find
(Natural News) In search of mitochondrial disease treatments, researchers found that some antioxidant compounds could be effective in treating mitochondrial disease. In their study, the researchers examined seven antioxidant compounds in two animal models of mitochondrial disease: Zebrafish (Danio rerio) and the worm species Caenorhabditis elegans. In addition, they used cultures of fibroblasts or skin... (Source: NaturalNews.com)
Source: NaturalNews.com - April 30, 2018 Category: Consumer Health News Source Type: news

MFN2 agonists reverse mitochondrial defects in preclinical models of Charcot-Marie-Tooth disease type 2A
Mitofusins (MFNs) promote fusion-mediated mitochondrial content exchange and subcellular trafficking. Mutations in Mfn2 cause neurodegenerative Charcot-Marie-Tooth disease type 2A (CMT2A). We showed that MFN2 activity can be determined by Met376 and His380 interactions with Asp725 and Leu727 and controlled by PINK1 kinase–mediated phosphorylation of adjacent MFN2 Ser378. Small-molecule mimics of the peptide-peptide interface of MFN2 disrupted this interaction, allosterically activating MFN2 and promoting mitochondrial fusion. These first-in-class mitofusin agonists overcame dominant mitochondrial defects provoked in ...
Source: ScienceNOW - April 19, 2018 Category: Science Authors: Rocha, A. G., Franco, A., Krezel, A. M., Rumsey, J. M., Alberti, J. M., Knight, W. C., Biris, N., Zacharioudakis, E., Janetka, J. W., Baloh, R. H., Kitsis, R. N., Mochly-Rosen, D., Townsend, R. R., Gavathiotis, E., Dorn, G. W. Tags: Cell Biology, Medicine, Diseases reports Source Type: news

Poor muscle health a complication of type 1 diabetes
Even active young adults with the disease have mitochondrial changes linked to cell damage Related items fromOnMedica Final piece of type 1 diabetes puzzle solved Overview of type 1 diabetes All pregnant women with type 1 diabetes should be offered continuous glucose monitoring Intensive weight loss can ‘reverse’ type 2 diabetes Five distinct types of diabetes, not just two, suggests study (Source: OnMedica Latest News)
Source: OnMedica Latest News - April 18, 2018 Category: UK Health Source Type: news

MitoCPR--A surveillance pathway that protects mitochondria in response to protein import stress
Mitochondrial functions are essential for cell viability and rely on protein import into the organelle. Various disease and stress conditions can lead to mitochondrial import defects. We found that inhibition of mitochondrial import in budding yeast activated a surveillance mechanism, mitoCPR, that improved mitochondrial import and protected mitochondria during import stress. mitoCPR induced expression of Cis1, which associated with the mitochondrial translocase to reduce the accumulation of mitochondrial precursor proteins at the mitochondrial translocase. Clearance of precursor proteins depended on the Cis1-interacting A...
Source: ScienceNOW - April 12, 2018 Category: Science Authors: Weidberg, H., Amon, A. Tags: Cell Biology, Molecular Biology, Online Only r-articles Source Type: news

Scientists find excess mitochondrial iron, Huntington's disease link
(University of Wyoming) The research identifying a pathway for Huntington's disease helps lay the foundation for developing drug therapies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 11, 2018 Category: International Medicine & Public Health Source Type: news

In a severe childhood neurodegeneration, novel mechanism found
(Children's Hospital of Philadelphia) Neurology researchers investigating a rare but devastating neurological regression in infants have discovered the cause: gene mutations that severely disrupt crucial functions in mitochondria, the energy-producing structures within cells. The specific disease mechanism, in which mutations disrupt a critical mitochondrial enzyme, has not previously been implicated in a human disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 22, 2018 Category: International Medicine & Public Health Source Type: news

Intravenous arginine benefits children after acute metabolic strokes
(Children's Hospital of Philadelphia) Children with mitochondrial diseases who suffered acute metabolic strokes benefited from rapid intravenous treatment with the amino acid arginine, experiencing no side effects from the treatment. The diseases were caused by a range of different genetic disorders. In half of the stroke episodes, patients showed clinical improvements in symptoms such as seizures and partial paralysis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 9, 2018 Category: International Medicine & Public Health Source Type: news

Medical News Today: Parkinson's disease: Why do brain cells die?
A new study has shown that a mitochondrial molecule called cardiolipin helps to correctly fold alpha-synuclein protein, whose incorrectly folded forms are found in Lewy bodies. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 28, 2018 Category: Consumer Health News Tags: Parkinson's Disease Source Type: news

Parkinson's disease: Why do brain cells die?
A new study has shown that a mitochondrial molecule called cardiolipin helps to correctly fold alpha-synuclein protein, whose incorrectly folded forms are found in Lewy bodies. (Source: Parkinson's Disease News From Medical News Today)
Source: Parkinson's Disease News From Medical News Today - February 28, 2018 Category: Neurology Tags: Parkinson's Disease Source Type: news

Spermidine in health and disease
Interventions that delay aging and protect from age-associated disease are slowly approaching clinical implementation. Such interventions include caloric restriction mimetics, which are defined as agents that mimic the beneficial effects of dietary restriction while limiting its detrimental effects. One such agent, the natural polyamine spermidine, has prominent cardioprotective and neuroprotective effects and stimulates anticancer immunosurveillance in rodent models. Moreover, dietary polyamine uptake correlates with reduced cardiovascular and cancer-related mortality in human epidemiological studies. Spermidine preserves...
Source: ScienceNOW - January 25, 2018 Category: Science Authors: Madeo, F., Eisenberg, T., Pietrocola, F., Kroemer, G. Tags: Cell Biology, Medicine, Diseases, Online Only review Source Type: news

Medical News Today: Parkinson's: How a 'bad' enzyme might protect the brain
Reduced levels of a mitochondrial enzyme were previously thought to destroy neurons in Parkinson's disease. The opposite may, in fact, be the case. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 17, 2018 Category: Consumer Health News Tags: Parkinson's Disease Source Type: news

Parkinson's: How a 'bad' enzyme might protect the brain
Reduced levels of a mitochondrial enzyme were previously thought to destroy neurons in Parkinson's disease. The opposite may, in fact, be the case. (Source: Parkinson's Disease News From Medical News Today)
Source: Parkinson's Disease News From Medical News Today - January 17, 2018 Category: Neurology Tags: Parkinson's Disease Source Type: news

How incurable mitochondrial diseases strike previously unaffected families
(Medical Research Council) Researchers have shown for the first time how children can inherit a severe -- potentially fatal -- mitochondrial disease from a healthy mother. The study, led by researchers from the MRC Mitochondrial Biology Unit at the University of Cambridge, reveals that healthy people harbor mutations in their mitochondrial DNA and explains how cases of severe mitochondrial disease can appear unexpectedly in previously unaffected families. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 15, 2018 Category: International Medicine & Public Health Source Type: news

Can vitamins and dietary supplements benefit patients with mitochondrial disease?
(Children's Hospital of Philadelphia) Defects in mitochondria, the tiny structures that power cells by functioning as biological batteries, cause an array of complex disorders that can affect any and all organs and systems. In the absence of validated, effective drug treatments, patients with mitochondrial disease often take a variety of vitamins and supplements, substances that are largely unstandardized, unregulated, and unproven. Experts in the field are calling for systematic studies to evaluate nutritional interventions. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 10, 2018 Category: International Medicine & Public Health Source Type: news

New brainstem changes identified in Parkinson's disease
(Newcastle University) A pioneering study has found that patients with Parkinson's disease have more errors in the mitochondrial DNA within the brainstem, leading to increased cell death in that area. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 4, 2018 Category: International Medicine & Public Health Source Type: news

A New Form of This Miracle Nutrient Is 8 Times More Powerful …
CoQ10 has made the mainstream. You can find it everywhere. But the type of CoQ10 I want to tell you about has been completely ignored. That’s too bad, because this new form is 8 times better at getting into your blood and staying there. And that’s where it has its miracle-like anti-aging effects. This new form of CoQ10 may give you the opportunity to live disease-free for the rest of your life. Today, I’ll show you how this new “reduced” form of CoQ10 gives you greater power to prevent and reverse disease. You’ll also discover that it ramps up your energy levels and slows your aging proc...
Source: Al Sears, MD Natural Remedies - January 3, 2018 Category: Complementary Medicine Authors: Francisco Cabrera Tags: Nutrition antioxidants CoQ10 ubiquinol Source Type: news

Improving cellular health - The key to reversing disease symptoms
(Natural News) Although the mitochondria, those tiny structures inside our cells, are absolutely essential to energy production and longevity – mitochondrial health has been largely overlooked and ignored by Western medicine. Think about it: if we (as a society) fully appreciated the importance of improving cellular energy (and took action) – many of our current... (Source: NaturalNews.com)
Source: NaturalNews.com - January 3, 2018 Category: Consumer Health News Source Type: news

Mitochondrial disease: Death of boy 'has to be for something'
Parents of a three-year-old who died from a rare illness said they want to "learn" from his death. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - December 30, 2017 Category: Consumer Health News Source Type: news

UCLA grant program funds interdisciplinary brain cancer research
When a neurosurgeon looks at a glioblastoma, an aggressive form of brain cancer, she sees a dark mass bullying its way through the brain. When an oncologist talks to a patient with glioblastoma, he tempers expectations, talking in months rather than years. When a molecular biologist thinks about glioblastoma, she thinks about the tumor ’s sweet tooth — the sugar it consumes to fuel its frenetic growth. And when you put all these people together — you get a plan to fight cancer.Armed with new research tools and a grant from the David Geffen School of Medicine ’s newSeed Grant Program, a team of UCLA ...
Source: UCLA Newsroom: Health Sciences - December 18, 2017 Category: Universities & Medical Training Source Type: news

Connecticut couple loses two children from rare disease
A couple from Connecticut lost two of their children eight weeks apart from a rare mitochondrial disease in 2014. Now they say their experience has made them better parents to their other two children. (Source: the Mail online | Health)
Source: the Mail online | Health - December 6, 2017 Category: Consumer Health News Source Type: news

Mitochondrial protein in cardiac muscle cells linked to heart failure, study finds
(Georgia State University) Reducing a protein found in the mitochondria of cardiac muscle cells initiates cardiac dysfunction and heart failure, a finding that could provide insight for new treatments for cardiovascular diseases, a study led by Georgia State University has shown. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 5, 2017 Category: International Medicine & Public Health Source Type: news

MEET the next generation of mitochondrial researchers
An EU-funded project has trained a new generation of researchers in mitochondrial disease - a range of rare disorders emerging as a new field of medical interest. The research, which included the discovery of novel genes associated with the disease, is feeding into the search for better diagnosis and treatment for the disorder. (Source: EUROPA - Research Information Centre)
Source: EUROPA - Research Information Centre - November 13, 2017 Category: Research Source Type: news

Senior Research Laboratory Technician – full-time (Fixed Term)
Location  Department of Physiology, Development and NeuroscienceSalary:£22,214 -£25,728Reference:  PM13702Closing Date: 30 November 2017 We are looking for an experienced and enthusiastic individual to join the groups ofProfessor Abigail Fowden andDr Andrew Murray.  Collectively, their research focuses on mitochondrial function during development and ageing, and how conditions during early life programme development and increase susceptibility to adult-onset degenerative diseases. They will provide mainly molecular biology support as well as some ass...
Source: Society for Endocrinology - November 10, 2017 Category: Endocrinology Source Type: news

Early intervention may hold key to treatment of Friedreich's ataxia
(The Company of Biologists) Current treatments may be administered too late to target Friedreich's ataxia effectively. New research using a slow-onset frataxin knock-in/knockout mouse model showed significantly reduced levels of mitochondrial biosynthesis proteins and early mitochondrial deficiency in the cerebellar cortex, even at pre-symptomatic stages of development. This suggests that the progressive degeneration in mitochondrial function seen in individuals with Friedreich's ataxia is not only the mechanism causing the disease, but also a potential biomarker and therapeutic target. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 8, 2017 Category: International Medicine & Public Health Source Type: news

New clinical care guidelines issued for patients with mitochondrial disease
(Children's Hospital of Philadelphia) Physicians who see patients with mitochondrial disease now have a practical new tool -- a set of guidelines for managing and caring for those patients. Occurring in at least one in 4,500 individuals, mitochondrial disease is caused by defects in genes affecting the function of mitochondria, crucial energy-producing structures found in every cell. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 24, 2017 Category: International Medicine & Public Health Source Type: news

Stop Your Body Attacking Itself
Modern medicine has no cure for autoimmune diseases — and, sadly, most doctors don’t understand them. I’m talking about disorders like rheumatoid arthritis, type 1 diabetes, lupus, fibromyalgia, chronic fatigue syndrome, psoriasis, multiple sclerosis (MS) and more. In all, there are about 80 autoimmune diseases affecting organs throughout the body. They occur when your own immune system becomes overactive and attacks your body instead of diseases and foreign invaders. The standard mainstream treatment for most autoimmune disorders relies on Big Pharma drugs that cover up symptoms or suppress your immun...
Source: Al Sears, MD Natural Remedies - October 5, 2017 Category: Complementary Medicine Authors: Al Sears Tags: Anti-Aging Source Type: news

The Anti-Aging Benefits of Curcumin
I've met a lot of people in my travels over the past few decades. I don't remember all of the names and faces, but there are some that I'll remember for the rest of my life… One is an older woman I met while I was studying Ayurvedic medicine in India in the 1990s. I assumed by her appearance that she was in her late 70s. She was active and engaging. I remember thinking she looked great for her age. And then she dropped the bomb… She told me she was 109! I thought she was pulling my leg at first. But when she introduced me to her 75-year-old granddaughter, I knew she wasn't kidding. When I ask...
Source: Al Sears, MD Natural Remedies - October 3, 2017 Category: Complementary Medicine Authors: Al Sears Tags: Anti-Aging Nutrition Source Type: news

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinsons disease
Mitochondrial and lysosomal dysfunction have been implicated in substantia nigra dopaminergic neurodegeneration in Parkinson’s disease (PD), but how these pathways are linked in human neurons remains unclear. Here we studied dopaminergic neurons derived from patients with idiopathic and familial PD. We identified a time-dependent pathological cascade beginning with mitochondrial oxidant stress leading to oxidized dopamine accumulation and ultimately resulting in reduced glucocerebrosidase enzymatic activity, lysosomal dysfunction, and α-synuclein accumulation. This toxic cascade was observed in human, but not i...
Source: ScienceNOW - September 21, 2017 Category: Science Authors: Burbulla, L. F., Song, P., Mazzulli, J. R., Zampese, E., Wong, Y. C., Jeon, S., Santos, D. P., Blanz, J., Obermaier, C. D., Strojny, C., Savas, J. N., Kiskinis, E., Zhuang, X., Krüger, R., Surmeier, D. J., Krainc, D. Tags: Medicine, Diseases, Neuroscience r-articles Source Type: news

Upcoming Mesothelioma Symposium Filled with Hope
Discussions About Immunotherapy for Mesothelioma Cameron also will speak about engineering mesenchymal stem cells for immunotherapy. Clare Cameron, who is the executive director of the Pacific Mesothelioma Center (PMC) and not related to Dr. Robert Cameron, will talk about resources for research. Lein Hua-Feng, a nurse practitioner at PMC, will discuss the benefits of caregiver support groups. “The symposium will provide an unrivaled opportunity for both the medically savvy and general public, including mesothelioma patients,” Clare Cameron said. “You’ll hear about the most promising medical advance...
Source: Asbestos and Mesothelioma News - August 29, 2017 Category: Environmental Health Authors: Matt Mauney Tags: 7th annual International Symposium on Mesothelioma Angiogenesis Inhibition and Chemotherapy Arti Shukia Banaras Hindu University bap1 Center at the University Hospital of Siena clare cameron Dr. Anna Nowak Dr. Brian Cunniff Dr. David Sch Source Type: news

Stop Marketing Mitochondrial Procedure, FDA Tells Physician Stop Marketing Mitochondrial Procedure, FDA Tells Physician
Dr John Zhang's modification of a human embryo to prevent mitochondrial disease, also known as the'three-person baby'technique, has run afoul of the FDA because of congressional action in 2015.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 9, 2017 Category: Consumer Health News Tags: Pharmacist News Source Type: news

Doctor told to stop marketing 3-person baby technique
Dr John Zhang made headlines last September after helping a couple with mitochondrial disease to deliver a disease-free child, by inserting their DNA into the egg of a donor. (Source: the Mail online | Health)
Source: the Mail online | Health - August 7, 2017 Category: Consumer Health News Source Type: news

Family fights to save boy with Charlie Gard-like disease
Four-month-old Russell Cruzan III, known as Bubby, from Michigan, has a rare mitochondrial disorder. It is the same one that killed British baby Charlie Gard on Friday, but is progressing slower. (Source: the Mail online | Health)
Source: the Mail online | Health - August 2, 2017 Category: Consumer Health News Source Type: news

Patient Reps: Bringing the voice of patients to FDA
By: Jack Kalavritinos At FDA we never lose sight of the fact that the work we do in evaluating and approving new medical products is done to benefit patients. Increasingly, that means taking into account the views and expertise of patients and their caregivers, because they provide a unique voice and perspective and know best what they are living with on a day-to-day basis. Earlier this month, for instance, we announced the creation of the first advisory committee made up solely of patients and caregivers, who will provide advice on complex issues related to medical devices. Another way we incorporate the patient viewpoint...
Source: Mass Device - July 31, 2017 Category: Medical Devices Authors: Danielle Kirsh Tags: Blog FDA Voice Source Type: news

Newton biotech says drug targeting cell's energy center shows promise
A Newton biotech says it has moved one step closer to developing the first treatment for rare genetic diseases of the mitochondria — the powerhouses of the cell that create 90 percent of the human body’s energy. Privately held Stealth BioTherapeutics on Thursday unveiled what it characterized as positive data from a Phase 2 study of its potential treatment for "mitochondrial myopathy," muscle weakness caused by a broad cla ss of diseases. The 50-employee company, which has raised around $200… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - June 29, 2017 Category: Pharmaceuticals Authors: Max Stendahl Source Type: news

Mitochondrial disease has a disproportionate healthcare burden in US
(Children's Hospital of Philadelphia) Mitochondrial diseases are a diverse group of disorders caused by mutated genes that impair energy production in a patient's cells, often with severe effects. Patients with these diseases incur high medical costs for hospitalization, and suffer higher-than-typical rates of comorbid diseases and in-hospital mortality. Researchers who analyzed those costs say their findings underscore the importance of developing preventive strategies and therapies for these illnesses. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 28, 2017 Category: International Medicine & Public Health Source Type: news

Mitoconix Bio Raises $20 Million in Series A Funding to Develop Neurodegenerative Disease Therapies
Proceeds will be used to advance the Company's lead product through preclinical and clinical development and expand its therapeutic pipeline for treating neurodegenerative disorders by improving mitochondrial function NESS ZIONA, Israel, June 27, 2017 -... Biopharmaceuticals, Neurology, Venture Capital Mitoconix Bio, Huntington's disease (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - June 27, 2017 Category: Pharmaceuticals Source Type: news

How to Protect Your Brain Against Alzheimer ’s
A few weeks ago, Big Pharma giant Merck canceled the clinical trial for its latest “promising” Alzheimer’s drug. Why? It was a total flop. The same thing happened four months ago with a drug that Eli Lilly was testing. The reality is that more than 99% of Alzheimer’s drugs fail in development. This proves that mainstream medicine has no clue what causes this brain-wasting condition. So what’s really going on? A big part of the problem is in the very air we breathe. And the closer you live to a major roadway or urban center, the worse it is&hel...
Source: Al Sears, MD Natural Remedies - June 22, 2017 Category: Complementary Medicine Authors: Cathy Card Tags: Brain Health Nutrition Alzheimer's cognitive decline pollution toxins Source Type: news

6 Ways To Survive Summer Travel With A Chronic Illness
Two summers ago, I planned the family road trip of a lifetime. I bought an inexpensive and used camping trailer, loaded it up with everything from toiletries to food, and set out on a 21-day road trip through six western states. I planned our route meticulously, lining up activities and stops along the way, but what got lost in the shuffle was my own chronic health needs. I assumed I would be able to stretch out my regular medical infusions to allow for my travel or refill my prescriptions on-the-go, but I quickly learned how wrong I was. I spent way too much of my vacation tackling my medical challenges instead of enjoyin...
Source: Healthy Living - The Huffington Post - June 14, 2017 Category: Consumer Health News Source Type: news

Aberrant telomere length and mitochondrial DNA copy number in suicide completers - Otsuka I, Izumi T, Boku S, Kimura A, Zhang Y, Mouri K, Okazaki S, Shiroiwa K, Takahashi M, Ueno Y, Shirakawa O, Sora I, Hishimoto A.
Short telomere length (TL) occurs in individuals under psychological stress, and with various psychiatric diseases. Recent studies have also reported mitochondrial DNA copy number (mtDNAcn) alterations under several neuropsychiatric conditions. However, no... (Source: SafetyLit)
Source: SafetyLit - June 14, 2017 Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news

Potential therapeutic target for Parkinson's disease
Investigations by scientists in Japan illustrate how the loss of a key mitochondrial protein facilitates the progression of Parkinson's disease. The findings are published in Nature Communications. (Source: Parkinson's Disease News From Medical News Today)
Source: Parkinson's Disease News From Medical News Today - June 13, 2017 Category: Neurology Tags: Parkinson's Disease Source Type: news

Neurodegenerative disease mechanism and potential drug identified
(University of California - Davis) Two new, UC Davis-led studies of neurodegenerative diseases linked to mitochondrial defects offer hope for developing a new biomarker for research and diagnostics, and a drug for treating such diseases. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - June 6, 2017 Category: International Medicine & Public Health Source Type: news

Disease Awareness Months Work, Even If You Don't Wear The Ribbon
June ​is the month for more than 10 disease-related awareness campaigns, including Myasthenia Gravis Awareness Month, National Congenital Cytomegalovirus Awareness Month and National Scleroderma Awareness Month. It also hosts a handful of awareness weeks and days, ranging from Helen Keller Deaf-Blind Awareness Week to World Sickle Cell Day. June’s awareness list is shorter than most, but every month is full of diseases and disorders to take note of. You probably haven’t heard of half of them, and you’re not alone. So what’s the point of an awareness day, week or month? To understand the chall...
Source: Healthy Living - The Huffington Post - June 2, 2017 Category: Consumer Health News Source Type: news

Parents of sick baby say therapy in US is son's 'last hope' of survival
Chris Gard and Connie Yates want appeal court judges to overrule earlier decision for hospital to withdraw Charlie ’s life supportA couple who want to take their sick baby son abroad for treatment have asked three court of appeal judges not to take away their “only remaining hope” for his survival.Chris Gard and Connie Yates want permission to take nine-month-old Charlie, who has a form of mitochondrial disease that causes brain damage and muscle problems, to the US for a therapy trial.Continue reading... (Source: Guardian Unlimited Science)
Source: Guardian Unlimited Science - May 23, 2017 Category: Science Authors: Press Association Tags: Court of appeal UK news Neuroscience US healthcare NHS Hospitals Genetics Biology US news Law London Source Type: news

Family history of Alzheimer's may alter metabolic gene that increases risk for disease
(Iowa State University) A new Iowa State University study may have identified the link that explains years of conflicting research over a mitochondrial gene and the risk for Alzheimer's disease. Researchers found a dramatic difference in the gene's impact on memory, general cognitive function and risk based on a family history of Alzheimer's disease and the length of a specific section of the gene. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 23, 2017 Category: International Medicine & Public Health Source Type: news

Low oxygen reverses mitochondrial disease in mice
Hypoxia reverses brain damage caused by mitochondrial dysfunction, a team finds. The approach might one day point to new therapies for people with Leigh syndrome and other mitochondrial disorders. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 8, 2017 Category: Science Source Type: news

KU Med researchers test new approach to Alzheimer's
The Kansas City Area Life Sciences Institute Inc. re-launched its Collaborate2Cure series on Monday, with two speakers sharing new approaches to treating Alzheimer's disease. In the coming months, area researchers will present on the topic of mitochondrial dysfunction, with the potential to land a $50,000 grant for collaborative research. The free weekly seminars take place 4 to 6 p.m. every Monday at the University of Kansas Medical Center's Research Institute in Fairway. Registration and archived… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - May 2, 2017 Category: Pharmaceuticals Authors: Elise Reuter Source Type: news

KU Med researchers test new approach to Alzheimer's
The Kansas City Area Life Sciences Institute Inc. re-launched its Collaborate2Cure series on Monday, with two speakers sharing new approaches to treating Alzheimer's disease. In the coming months, area researchers will present on the topic of mitochondrial dysfunction, with the potential to land a $50,000 grant for collaborative research. The free weekly seminars take place 4 to 6 p.m. every Monday at the University of Kansas Medical Center's Research Institute in Fairway. Registration and archived… (Source: bizjournals.com Health Care:Biotechnology headlines)
Source: bizjournals.com Health Care:Biotechnology headlines - May 2, 2017 Category: Biotechnology Authors: Elise Reuter Source Type: news

Unravelling the mystery of DNA attacks in cells' powerhouse could pave way for new cancer treatments
A five-year study has found the mechanism responsible for repairing damage to mitochondrial DNA. This discovery could pave the way for new treatments for cancer and neurodegenerative diseases, say the researchers. This research may also have important implications for clinical advances in so called ‘three-parent baby’ mitochondrial donation. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 28, 2017 Category: Science Source Type: news

Vital role for mitochondrial calcium exchange in heart function
Scientists have long thought that calcium transport into mitochondria is a key signal linking cardiac workload, or how hard the heart pumps, with energy production. Now, in a major breakthrough, researchers show that the exit of calcium from mitochondria serves a critical role in heart function and may represent a powerful therapeutic approach to limit heart disease. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 26, 2017 Category: Science Source Type: news

4 Ways Researchers Are Pushing The Boundaries Of Making Babies
Infertility treatment is more common than ever, thanks to technology.  More than 70,000 babies were born through in-vitro fertilization in 2014, according to the latest Centers for Disease Control and Prevention data. That’s an increase of nearly 10,000 babies, compared with five years earlier. Men and women are increasingly likely to seek medical help for reasons that include reduced stigma and more employers offering coverage for IVF. But one big reason for the trend is clear: Fertility doctors are getting better at making babies. “Science is moving at a pace that’s very different th...
Source: Science - The Huffington Post - April 25, 2017 Category: Science Source Type: news