MitoCPR--A surveillance pathway that protects mitochondria in response to protein import stress
Mitochondrial functions are essential for cell viability and rely on protein import into the organelle. Various disease and stress conditions can lead to mitochondrial import defects. We found that inhibition of mitochondrial import in budding yeast activated a surveillance mechanism, mitoCPR, that improved mitochondrial import and protected mitochondria during import stress. mitoCPR induced expression of Cis1, which associated with the mitochondrial translocase to reduce the accumulation of mitochondrial precursor proteins at the mitochondrial translocase. Clearance of precursor proteins depended on the Cis1-interacting A...
Source: ScienceNOW - April 12, 2018 Category: Science Authors: Weidberg, H., Amon, A. Tags: Cell Biology, Molecular Biology, Online Only r-articles Source Type: news
Scientists find excess mitochondrial iron, Huntington's disease link
(University of Wyoming) The research identifying a pathway for Huntington's disease helps lay the foundation for developing drug therapies. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 11, 2018 Category: International Medicine & Public Health Source Type: news
In a severe childhood neurodegeneration, novel mechanism found
(Children's Hospital of Philadelphia) Neurology researchers investigating a rare but devastating neurological regression in infants have discovered the cause: gene mutations that severely disrupt crucial functions in mitochondria, the energy-producing structures within cells. The specific disease mechanism, in which mutations disrupt a critical mitochondrial enzyme, has not previously been implicated in a human disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 22, 2018 Category: International Medicine & Public Health Source Type: news
Intravenous arginine benefits children after acute metabolic strokes
(Children's Hospital of Philadelphia) Children with mitochondrial diseases who suffered acute metabolic strokes benefited from rapid intravenous treatment with the amino acid arginine, experiencing no side effects from the treatment. The diseases were caused by a range of different genetic disorders. In half of the stroke episodes, patients showed clinical improvements in symptoms such as seizures and partial paralysis. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 9, 2018 Category: International Medicine & Public Health Source Type: news
Parkinson's disease: Why do brain cells die?
A new study has shown that a mitochondrial molecule called cardiolipin helps to correctly fold alpha-synuclein protein, whose incorrectly folded forms are found in Lewy bodies. (Source: Parkinson's Disease News From Medical News Today)
Source: Parkinson's Disease News From Medical News Today - February 28, 2018 Category: Neurology Tags: Parkinson's Disease Source Type: news
Medical News Today: Parkinson's disease: Why do brain cells die?
A new study has shown that a mitochondrial molecule called cardiolipin helps to correctly fold alpha-synuclein protein, whose incorrectly folded forms are found in Lewy bodies. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - February 28, 2018 Category: Consumer Health News Tags: Parkinson's Disease Source Type: news
Spermidine in health and disease
Interventions that delay aging and protect from age-associated disease are slowly approaching clinical implementation. Such interventions include caloric restriction mimetics, which are defined as agents that mimic the beneficial effects of dietary restriction while limiting its detrimental effects. One such agent, the natural polyamine spermidine, has prominent cardioprotective and neuroprotective effects and stimulates anticancer immunosurveillance in rodent models. Moreover, dietary polyamine uptake correlates with reduced cardiovascular and cancer-related mortality in human epidemiological studies. Spermidine preserves...
Source: ScienceNOW - January 25, 2018 Category: Science Authors: Madeo, F., Eisenberg, T., Pietrocola, F., Kroemer, G. Tags: Cell Biology, Medicine, Diseases, Online Only review Source Type: news
Medical News Today: Parkinson's: How a 'bad' enzyme might protect the brain
Reduced levels of a mitochondrial enzyme were previously thought to destroy neurons in Parkinson's disease. The opposite may, in fact, be the case. (Source: Health News from Medical News Today)
Source: Health News from Medical News Today - January 17, 2018 Category: Consumer Health News Tags: Parkinson's Disease Source Type: news
Parkinson's: How a 'bad' enzyme might protect the brain
Reduced levels of a mitochondrial enzyme were previously thought to destroy neurons in Parkinson's disease. The opposite may, in fact, be the case. (Source: Parkinson's Disease News From Medical News Today)
Source: Parkinson's Disease News From Medical News Today - January 17, 2018 Category: Neurology Tags: Parkinson's Disease Source Type: news
How incurable mitochondrial diseases strike previously unaffected families
(Medical Research Council) Researchers have shown for the first time how children can inherit a severe -- potentially fatal -- mitochondrial disease from a healthy mother. The study, led by researchers from the MRC Mitochondrial Biology Unit at the University of Cambridge, reveals that healthy people harbor mutations in their mitochondrial DNA and explains how cases of severe mitochondrial disease can appear unexpectedly in previously unaffected families. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 15, 2018 Category: International Medicine & Public Health Source Type: news
Can vitamins and dietary supplements benefit patients with mitochondrial disease?
(Children's Hospital of Philadelphia) Defects in mitochondria, the tiny structures that power cells by functioning as biological batteries, cause an array of complex disorders that can affect any and all organs and systems. In the absence of validated, effective drug treatments, patients with mitochondrial disease often take a variety of vitamins and supplements, substances that are largely unstandardized, unregulated, and unproven. Experts in the field are calling for systematic studies to evaluate nutritional interventions. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 10, 2018 Category: International Medicine & Public Health Source Type: news
New brainstem changes identified in Parkinson's disease
(Newcastle University) A pioneering study has found that patients with Parkinson's disease have more errors in the mitochondrial DNA within the brainstem, leading to increased cell death in that area. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 4, 2018 Category: International Medicine & Public Health Source Type: news
A New Form of This Miracle Nutrient Is 8 Times More Powerful …
CoQ10 has made the mainstream. You can find it everywhere.
But the type of CoQ10 I want to tell you about has been completely ignored.
That’s too bad, because this new form is 8 times better at getting into your blood and staying there. And that’s where it has its miracle-like anti-aging effects.
This new form of CoQ10 may give you the opportunity to live disease-free for the rest of your life.
Today, I’ll show you how this new “reduced” form of CoQ10 gives you greater power to prevent and reverse disease. You’ll also discover that it ramps up your energy levels and slows your aging process down by a remarkable...
Source: Al Sears, MD Natural Remedies - January 3, 2018 Category: Complementary Medicine Authors: Francisco Cabrera Tags: Nutrition antioxidants CoQ10 ubiquinol Source Type: news
Mitochondrial disease: Death of boy 'has to be for something'
Parents of a three-year-old who died from a rare illness said they want to "learn" from his death. (Source: BBC News | Health | UK Edition)
Source: BBC News | Health | UK Edition - December 30, 2017 Category: Consumer Health News Source Type: news
UCLA grant program funds interdisciplinary brain cancer research
When a neurosurgeon looks at a glioblastoma, an aggressive form of brain cancer, she sees a dark mass bullying its way through the brain. When an oncologist talks to a patient with glioblastoma, he tempers expectations, talking in months rather than years. When a molecular biologist thinks about glioblastoma, she thinks about the tumor ’s sweet tooth — the sugar it consumes to fuel its frenetic growth. And when you put all these people together — you get a plan to fight cancer.Armed with new research tools and a grant from the David Geffen School of Medicine ’s newSeed Grant Program, a team of UCLA researchers, inc...
Source: UCLA Newsroom: Health Sciences - December 18, 2017 Category: Universities & Medical Training Source Type: news
