Mitochondrial protein in cardiac muscle cells linked to heart failure, study finds
(Georgia State University) Reducing a protein found in the mitochondria of cardiac muscle cells initiates cardiac dysfunction and heart failure, a finding that could provide insight for new treatments for cardiovascular diseases, a study led by Georgia State University has shown. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - December 5, 2017 Category: International Medicine & Public Health Source Type: news
MEET the next generation of mitochondrial researchers
An EU-funded project has trained a new generation of researchers in mitochondrial disease - a range of rare disorders emerging as a new field of medical interest. The research, which included the discovery of novel genes associated with the disease, is feeding into the search for better diagnosis and treatment for the disorder. (Source: EUROPA - Research Information Centre)
Source: EUROPA - Research Information Centre - November 13, 2017 Category: Research Source Type: news
Senior Research Laboratory Technician – full-time (Fixed Term)
Location Department of Physiology, Development and NeuroscienceSalary:£22,214 -£25,728Reference: PM13702Closing Date: 30 November 2017 We are looking for an experienced and enthusiastic individual to join the groups ofProfessor Abigail Fowden andDr Andrew Murray. Collectively, their research focuses on mitochondrial function during development and ageing, and how conditions during early life programme development and increase susceptibility to adult-onset degenerative diseases. They will provide mainly molecular biology support as well as some ass...
Source: Society for Endocrinology - November 10, 2017 Category: Endocrinology Source Type: news
Early intervention may hold key to treatment of Friedreich's ataxia
(The Company of Biologists) Current treatments may be administered too late to target Friedreich's ataxia effectively. New research using a slow-onset frataxin knock-in/knockout mouse model showed significantly reduced levels of mitochondrial biosynthesis proteins and early mitochondrial deficiency in the cerebellar cortex, even at pre-symptomatic stages of development. This suggests that the progressive degeneration in mitochondrial function seen in individuals with Friedreich's ataxia is not only the mechanism causing the disease, but also a potential biomarker and therapeutic target. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - November 8, 2017 Category: International Medicine & Public Health Source Type: news
New clinical care guidelines issued for patients with mitochondrial disease
(Children's Hospital of Philadelphia) Physicians who see patients with mitochondrial disease now have a practical new tool -- a set of guidelines for managing and caring for those patients. Occurring in at least one in 4,500 individuals, mitochondrial disease is caused by defects in genes affecting the function of mitochondria, crucial energy-producing structures found in every cell. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - October 24, 2017 Category: International Medicine & Public Health Source Type: news
Stop Your Body Attacking Itself
Modern medicine has no cure for autoimmune diseases — and, sadly, most doctors don’t understand them.
I’m talking about disorders like rheumatoid arthritis, type 1 diabetes, lupus, fibromyalgia, chronic fatigue syndrome, psoriasis, multiple sclerosis (MS) and more.
In all, there are about 80 autoimmune diseases affecting organs throughout the body. They occur when your own immune system becomes overactive and attacks your body instead of diseases and foreign invaders.
The standard mainstream treatment for most autoimmune disorders relies on Big Pharma drugs that cover up symptoms or suppress your immune system, an...
Source: Al Sears, MD Natural Remedies - October 5, 2017 Category: Complementary Medicine Authors: Al Sears Tags: Anti-Aging Source Type: news
The Anti-Aging Benefits of Curcumin
I've met a lot of people in my travels over the past few decades. I don't remember all of the names and faces, but there are some that I'll remember for the rest of my life…
One is an older woman I met while I was studying Ayurvedic medicine in India in the 1990s. I assumed by her appearance that she was in her late 70s. She was active and engaging. I remember thinking she looked great for her age.
And then she dropped the bomb…
She told me she was 109!
I thought she was pulling my leg at first. But when she introduced me to her 75-year-old granddaughter, I knew she wasn't kidding.
When I asked...
Source: Al Sears, MD Natural Remedies - October 3, 2017 Category: Complementary Medicine Authors: Al Sears Tags: Anti-Aging Nutrition Source Type: news
Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinsons disease
Mitochondrial and lysosomal dysfunction have been implicated in substantia nigra dopaminergic neurodegeneration in Parkinson’s disease (PD), but how these pathways are linked in human neurons remains unclear. Here we studied dopaminergic neurons derived from patients with idiopathic and familial PD. We identified a time-dependent pathological cascade beginning with mitochondrial oxidant stress leading to oxidized dopamine accumulation and ultimately resulting in reduced glucocerebrosidase enzymatic activity, lysosomal dysfunction, and α-synuclein accumulation. This toxic cascade was observed in human, but not i...
Source: ScienceNOW - September 21, 2017 Category: Science Authors: Burbulla, L. F., Song, P., Mazzulli, J. R., Zampese, E., Wong, Y. C., Jeon, S., Santos, D. P., Blanz, J., Obermaier, C. D., Strojny, C., Savas, J. N., Kiskinis, E., Zhuang, X., Krüger, R., Surmeier, D. J., Krainc, D. Tags: Medicine, Diseases, Neuroscience r-articles Source Type: news
Upcoming Mesothelioma Symposium Filled with Hope
Discussions About Immunotherapy for Mesothelioma
Cameron also will speak about engineering mesenchymal stem cells for immunotherapy.
Clare Cameron, who is the executive director of the Pacific Mesothelioma Center (PMC) and not related to Dr. Robert Cameron, will talk about resources for research. Lein Hua-Feng, a nurse practitioner at PMC, will discuss the benefits of caregiver support groups.
“The symposium will provide an unrivaled opportunity for both the medically savvy and general public, including mesothelioma patients,” Clare Cameron said. “You’ll hear about the most promising medical advance...
Source: Asbestos and Mesothelioma News - August 29, 2017 Category: Environmental Health Authors: Matt Mauney Tags: 7th annual International Symposium on Mesothelioma Angiogenesis Inhibition and Chemotherapy Arti Shukia Banaras Hindu University bap1 Center at the University Hospital of Siena clare cameron Dr. Anna Nowak Dr. Brian Cunniff Dr. David Sch Source Type: news
Stop Marketing Mitochondrial Procedure, FDA Tells Physician Stop Marketing Mitochondrial Procedure, FDA Tells Physician
Dr John Zhang ' s modification of a human embryo to prevent mitochondrial disease, also known as the ' three-person baby ' technique, has run afoul of the FDA because of congressional action in 2015.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - August 9, 2017 Category: Consumer Health News Tags: Pharmacist News Source Type: news
Doctor told to stop marketing 3-person baby technique
Dr John Zhang made headlines last September after helping a couple with mitochondrial disease to deliver a disease-free child, by inserting their DNA into the egg of a donor. (Source: the Mail online | Health)
Source: the Mail online | Health - August 7, 2017 Category: Consumer Health News Source Type: news
Family fights to save boy with Charlie Gard-like disease
Four-month-old Russell Cruzan III, known as Bubby, from Michigan, has a rare mitochondrial disorder. It is the same one that killed British baby Charlie Gard on Friday, but is progressing slower. (Source: the Mail online | Health)
Source: the Mail online | Health - August 2, 2017 Category: Consumer Health News Source Type: news
Patient Reps: Bringing the voice of patients to FDA
By: Jack Kalavritinos
At FDA we never lose sight of the fact that the work we do in evaluating and approving new medical products is done to benefit patients.
Increasingly, that means taking into account the views and expertise of patients and their caregivers, because they provide a unique voice and perspective and know best what they are living with on a day-to-day basis. Earlier this month, for instance, we announced the creation of the first advisory committee made up solely of patients and caregivers, who will provide advice on complex issues related to medical devices.
Another way we incorporate the patient viewpoint...
Source: Mass Device - July 31, 2017 Category: Medical Devices Authors: Danielle Kirsh Tags: Blog FDA Voice Source Type: news
Summer Conference 2018: Getting energy balance right
Discussion15:55 Refreshments16:15 Silver Medal Lecture:
From sugar to liver fat and public health: Systems biology driven studies in understanding non-alcoholic fatty liver disease pathogenesisDr J. Bernadette Moore, University of Leeds16:55 Original Communications session one18:25 Chair close day one18:30 Drinks receptionCall for Abstracts: Abstract submission hasnow closedfor the 2018 Summer Conference.Thank you to all who have submitted an abstract.When will I hear if my abstract has been accepted?
Authors will hear in June 2018 if their abstract has been accepted for presentation at the confere...
Source: The Nutrition Society - July 7, 2017 Category: Nutrition Authors: Miss Natalie Ofosu-Orchard Source Type: news
Newton biotech says drug targeting cell's energy center shows promise
A Newton biotech says it has moved one step closer to developing the first treatment for rare genetic diseases of the mitochondria — the powerhouses of the cell that create 90 percent of the human body’s energy.
Privately held Stealth BioTherapeutics on Thursday unveiled what it characterized as positive data from a Phase 2 study of its potential treatment for "mitochondrial myopathy," muscle weakness caused by a broad cla ss of diseases.
The 50-employee company, which has raised around $200… (Source: bizjournals.com Health Care:Pharmaceuticals headlines)
Source: bizjournals.com Health Care:Pharmaceuticals headlines - June 29, 2017 Category: Pharmaceuticals Authors: Max Stendahl Source Type: news
