Nutrients To Energize Your Mitochondria
For more than a decade now, I’ve been boosting my patients’ mitochondria with two super-nutrients — CoQ10 and pyrroloquinoline quinone, or PQQ.
You see, if you keep your mitochondria healthy, your body will have all the energy it’ll ever need to stay strong and ward off the diseases of aging.
The problem is that mainstream medicine is lagging way behind, so you won’t hear about this from your doctor.
But along with your telomeres, the cellular time keepers at the ends of your chromosomes, your mitochondria are key components in the anti-aging equation. Keeping them safe and charged is essential to healthy aging....
Source: Al Sears, MD Natural Remedies - May 18, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Health Source Type: news
The Zoo We Bear
By Drs. David Niesel and Norbert Herzog, Medical Discovery News
Bacteria and viruses live on and in us as part of our normal flora or microbiome. In fact, microbes outnumber our own cells by 10 to 100 to 1. But there are even more creatures that we share our lives with, parasites and vermin.
That sounds disgusting, vermin? Really?
Studies of these creatures are actually quite revealing about human evolution and migration. For example, all of us harbor a mite that lives in the hair follicles on our faces called Demodex folliculorum. They are tubular in shape with iddy biddy legs and live deep in our follicles. Somew...
Source: Science - The Huffington Post - May 17, 2016 Category: Science Source Type: news
Scientists identify key factor in mitochondrial calcium uptake and bioenergetics
Mitochondria are the energy-generating batteries of cells, but they also perform other critical functions, including protecting cells against calcium overload, a significant cause of cell death in certain cardiovascular and neurodegenerative diseases. Underlying this safety mechanism is a protein complex known as the mitochondrial Ca2+ uniporter (MCU). New work shows how MCU proteins come together to effect calcium uptake, shedding new light on the physiological role of the MCU complex and its importance to cellular bioenergetics. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - May 12, 2016 Category: Science Source Type: news
UCLA-led team develops new method to study mitochondrial DNA diseases
Alexander Patananan
The process of transferring mitochondria between cells using the nanoblade technology.
A UCLA-led team of researchers has demonstrated a new method to conduct research on mitochondrial DNA diseases — a broad group of debilitating genetic disorders that can affect the brain, heart and muscles.
The new method, which utilizes a technology developed by UCLA researchers that opens holes in the cell membrane, is described in a study published today in Cell Metabolism. The researchers say that it could pave the way for specific research on how and why these diseases occur, and point to pathways to develo...
Source: UCLA Newsroom: Health Sciences - May 10, 2016 Category: Universities & Medical Training Source Type: news
OCD and Medical Child Abuse
As I’ve written about before, our family faced many issues when my son Dan spent nine weeks at a residential treatment center for OCD. There’s no question the staff there knew how to treat OCD. What they didn’t know, and what they couldn’t know, was my son: his hopes, his dreams, his values, him.
Instead of being invited to work together with the staff to figure out the best plan for Dan, my husband and I felt shut out. We also sensed we were viewed as part of the problem. So when I read this New York Times article entitled “The New Child Abuse Panic,” I broke out into a sweat. This could have been us.
...
Source: Psych Central - May 8, 2016 Category: Psychiatry Authors: Janet Singer Tags: Abuse Caregivers Disorders Family General Obsessive-Compulsive Disorder Parenting Psychology Anxiety Avoidance Caregiving Child Abuse child welfare custody Justina Pelletier Maxine Eichner Ocd Stigma Source Type: news
Maryland mother sees daughter she was told wouldn't live past a YEAR celebrate 21st birthday
Julie Venners Christensen, 48, of Maryland, was told her daughter had mitochondrial disease - a rare illness that would cause her to go dead and blind and kill her. (Source: the Mail online | Health)
Source: the Mail online | Health - April 29, 2016 Category: Consumer Health News Source Type: news
Short bursts of intense exercise 'as good' as endurance training
Conclusion
The idea that a 10-minute workout could have the same benefits as spending 45 minutes in the gym is tempting. The researchers found it may improve specific markers of health, in one group of young men.
However, this is a small study in a specific population, and we don't know whether it would have comparable effects in older people or women. Also, we don't know the long-term effects of this type of training programme on people's health.
Studies that look at the effects of an intervention, whether it's exercise, diet or medicine, on health measures such as insulin resistance and oxygen uptake, can only give us a...
Source: NHS News Feed - April 28, 2016 Category: Consumer Health News Tags: Lifestyle/exercise Heart/lungs Diabetes Source Type: news
Role for oxidized mitochondrial DNA in lupus revealed
The neutrophils of systemic lupus erythematosus patients release oxidized DNA from their mitochondria that can stimulate an unwanted immune response, researchers have discovered. The study suggests that targeting the pathways that lead to the accumulation of this DNA and/or facilitate its removal could be new ways to treat this chronic autoimmune disease. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 18, 2016 Category: Science Source Type: news
Baylor study reveals role for oxidized mitochondrial DNA in lupus
(Rockefeller University Press) Researchers at the Baylor Institute for Immunology Research have discovered that the neutrophils of systemic lupus erythematosus patients release oxidized DNA from their mitochondria that can stimulate an unwanted immune response. The study, which will be published online April 18 in The Journal of Experimental Medicine, suggests that targeting the pathways that lead to the accumulation of this DNA and/or facilitate its removal could be new ways to treat this chronic autoimmune disease. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 18, 2016 Category: Global & Universal Source Type: news
[Report] Complementation of mitochondrial electron transport chain by manipulation of the NAD+/NADH ratio
A decline in electron transport chain (ETC) activity is associated with many human diseases. Although diminished mitochondrial adenosine triphosphate production is recognized as a source of pathology, the contribution of the associated reduction in the ratio of the amount of oxidized nicotinamide adenine dinucleotide (NAD+) to that of its reduced form (NADH) is less clear. We used a water-forming NADH oxidase from Lactobacillus brevis (LbNOX) as a genetic tool for inducing a compartment-specific increase of the NAD+/NADH ratio in human cells. We used LbNOX to demonstrate the dependence of key metabolic fluxes, gluconeogene...
Source: ScienceNOW - April 7, 2016 Category: Science Authors: Denis V. Titov Source Type: news
[Research Article] Hypoxia as a therapy for mitochondrial disease
Defects in the mitochondrial respiratory chain (RC) underlie a spectrum of human conditions, ranging from devastating inborn errors of metabolism to aging. We performed a genome-wide Cas9-mediated screen to identify factors that are protective during RC inhibition. Our results highlight the hypoxia response, an endogenous program evolved to adapt to limited oxygen availability. Genetic or small-molecule activation of the hypoxia response is protective against mitochondrial toxicity in cultured cells and zebrafish models. Chronic hypoxia leads to a marked improvement in survival, body weight, body temperature, behavior, neu...
Source: ScienceNOW - March 31, 2016 Category: Science Authors: Isha H. Jain Source Type: news
[This Week in Science] Thriving on a breath of low oxygen
Author: Paula A. Kiberstis (Source: ScienceNOW)
Source: ScienceNOW - March 31, 2016 Category: Science Authors: Paula A. Kiberstis Tags: Mitochondrial Disease Source Type: news
[Perspective] Mitochondrial disease therapy from thin air?
The mitochondrial oxidative phosphorylation (OXPHOS) system supplies most of the adenosine 59-triphosphate (ATP) in the human body. Defects in this system are among the most common genetic metabolic diseases, and many are associated with fatal, early-onset neurodegenerative conditions for which there are no effective treatments. On page 54 of this issue, Jain et al. (1) propose that restricting the oxygen supply to patients, who already have a defect in aerobic ATP synthesis, may be a form of therapy. This seems counterintuitive. How did the authors reach that conclusion?
Author: Eric A. Shoubridge (Source: ScienceNOW)
Source: ScienceNOW - March 31, 2016 Category: Science Authors: Eric A. Shoubridge Tags: Mitochondria Source Type: news
Antibiotics Side Effects on the Mitochondria
Science is just beginning to understand how important your mitochondria are to warding off the diseases of aging. And, as usual, mainstream medicine is lagging way behind.
Along with your telomeres, the cellular time keepers at the ends of your chromosomes, your mitochondria are another key component of the anti-aging equation.
You see, these tiny organelles in your cells are the power plants that turn fuel into energy for your body. Healthy mitochondria keep you young and energetic.
Research shows that damaged mitochondria can lead to:
Schizophrenia and bipolar disorder;
Alzheimer’s and Parkinson’...
Source: Al Sears, MD Natural Remedies - March 25, 2016 Category: Complementary Medicine Authors: Al Sears Tags: Natural Cures Source Type: news
Fatal Infantile Mitochondrial Disease With OPA1 MutationFatal Infantile Mitochondrial Disease With OPA1 Mutation
The authors establish a causal link between a pathogenic homozygous OPA1 mutation and human disease, emphasizing the vital role played by OPA1 in mitochondrial biogenesis. Journal of Medical Genetics (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 14, 2016 Category: Consumer Health News Tags: Pathology & Lab Medicine Journal Article Source Type: news
