Bacterial Peptides Improve Mitochondrial Function in Intestinal Tissues
This study reveals a potential treatment for human mitochondrial diseases.
Link: https://doi.org/10.1016/j.celrep.2024.114067 (Source: Fight Aging!)
Source: Fight Aging! - April 17, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 15th 2024
In conclusion, although several clinical trials targeting SnCs are ongoing, various questions about the biology of SnCs remain open, resulting in a gap between molecular and cellular data. Concerning the need, initiatives such as SenNet aiming to create openly accessible atlases of SnCs should contribute enormously to the area. Advances in understanding the subcellular structure, the heterogeneity, and the dynamics of SnCs require the integration of molecular and cellular techniques with data analysis packages to evaluate high throughput evidence from microscopy and flow cytometry. It is also necessary to develop new equip...
Source: Fight Aging! - April 14, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, April 8th 2024
In this study, we tested a stem cell secretome product, which contains extracellular vesicles and growth factors, cytoskeletal remodeling factors, and immunomodulatory factors. We examined the effects of 4 weeks of 2×/week unilateral intramuscular secretome injections (quadriceps) in ambulatory aged male C57BL/6 mice (22-24 months) compared to saline-injected aged-matched controls.
Secretome delivery substantially increased whole-body lean mass and decreased fat mass, corresponding to higher myofiber cross-sectional area and smaller adipocyte size, respectively. Secretome-treated mice also had greater whole-bod...
Source: Fight Aging! - April 7, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Reversal of Markers of Aging in Cells Following Small Molecule Partial Reprogramming
Partial reprogramming by exposure to Yamanaka factors resets many of the epigenetic changes characteristic of cells in aged tissue. This is a potential approach to the production of future rejuvenation therapies. At present, some research groups are attempting to move away from genetic interventions to find small molecules that can provoke reprogramming. There are some avenues that seem promising. Here, researchers assess the effects of partial reprogramming by small molecules on a range of omics data and functional parameters for cells, finding that the outcomes are much as one would expect for a successful protocol.
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Source: Fight Aging! - April 1, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, April 1st 2024
This study supports the proposed model that aging-related loss of colonic crypt epithelial cell AMP gene expression can promote increased relative abundances of Gn inflammaging-associated bacteria and gene expression markers of colonic inflammaging. These data may support new targets for aging-related therapies based on intestinal genes and microbiomes.
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A Skeptical View of the Role of Nuclear DNA Damage in Aging
https://www.fightaging.org/archives/2024/03/a-skeptical-view-of-the-role-of-nuclear-dna-damage-in-aging/
It is evident and settled that stochastic nuclear DNA damag...
Source: Fight Aging! - March 31, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Lipid Droplets in Microglia Involved in Alzheimer's Pathology
Microglia are innate immune cells resident in the central nervous system. Microglial dysfunction is clearly a contributing factor in the onset and progression of age-related neurodegenerative conditions, including Alzheimer's disease, as well as the accompanying chronic inflammation of brain tissue. As to why microglia become problematic and inflammatory, there are any number of possible contributing mechanisms to consider. Cellular senescence, mitochondrial dysfunction, reactions to cell debris or the presence of persistent viral infections, and more. In this vein, researchers here discuss excessive lipid accumulation in ...
Source: Fight Aging! - March 27, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Apigenin, Sleep, and Aging
For those following research into efforts to upregulate NAD+ levels to improve mitochondrial function, this paper is an interesting sidebar. Some degree of loss of NAD+ emerges from increased activity of CD38. Apigenin is a dietary supplement that can modestly influence both sleep and pace of aging, the latter in short-lived laboratory species at least. Apigenin can increase NAD+ levels by inhibiting CD38 activity. Like much of metabolism, this is all very interesting, but the effect sizes are nothing to write home about. If upregulating NAD+ levels is the goal, you'll do better by exercising. The fundamental flaw in so mu...
Source: Fight Aging! - March 26, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Predicting the Order of Arrival of the First Rejuvenation Therapies
It has been going on eight years since I last speculated on the order of arrival of the first rejuvenation therapies. Tempus fugit, and time for an updated version! Eight years is a long enough span of time for the first of those rejuvenation therapies to now exist, albeit in a prototypical form, arguably proven in principle but not concretely. The world progresses but my biases remain much the same: the first rejuvenation therapies to work well enough to merit the name will be based on the SENS vision, that aging is at root caused by a few classes of accumulated cell and tissue damage, and biotechnologies that either repa...
Source: Fight Aging! - March 25, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 25th 2024
This study also reports the expansion of satellite cells in human muscle with CR. This finding is critical to suggest translational relevance to the rodent data observed for more than a decade. Moreover, the increased expression of the plasminogen receptor Plg-RKT observed on human satellite cells during CR provided additional support for the theory that our rodent model is relevant to human biology.
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Interesting Insight into the Relationship Between TP53, Telomerase, and Telomere Length
https://www.fightaging.org/archives/2024/03/interesting-insight-into-the-relationship-between-t...
Source: Fight Aging! - March 24, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Aging Affects the Neural Regulation of Metabolism and Desired Food Intake
Researchers here make an interesting discovery in rats, finding an age-related change in the structure of specific neurons that encourages greater intake of calories and dysfunctional metabolism by suppressing satiation feedback. In rats this mechanism can be manipulated by diet and genetics to alter the pace at which older rats become overweight and metabolically abnormal. As is often the case in research, this discovery is a proximate cause to the problem of metabolic regulation, and it is entirely unclear as to how the deeper mechanisms of aging, such as chronic inflammation, mitochondrial dysfunction, and so forth, are...
Source: Fight Aging! - March 20, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Mitochondrial Dysfunction in the Aging of the Brain
Mitochondria are the power plants of the cell, primarily responsible for packaging adenosine triphosphate (ATP) molecules as chemical energy stores for use throughout the cell. Hundreds of mitochondria swarm inside every cell, the descendants of ancient symbiotic bacteria. These organelles retain many features characteristic of bacteria. For example, mitochondria contain a small circular genome, depleted of genes that have moved into the cell nucleus over evolutionary time. Mitochondria also constantly divide, fuse together, and swap component parts. Mitochondrial quality is controlled by the processes of mitophagy that re...
Source: Fight Aging! - March 19, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 11th 2024
In conclusion, this Mendelian randomization study found that Streptococcus was causally associated with Bioage acceleration. Further randomized controlled trials are needed to investigate its role in the aging process.
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Considering the Mechanisms of Vascular Calcification
https://www.fightaging.org/archives/2024/03/considering-the-mechanisms-of-vascular-calcification/
Harmful calcification of structures in the cardiovascular system proceeds alongside the development of the fatty lesions of atherosclerosis. Both disease processes are accelerated by chronic inflammation, but d...
Source: Fight Aging! - March 10, 2024 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Request for Startups in the Rejuvenation Biotechnology Space, 2024 Edition
Investors focused on funding biotechnology startups tend to exhibit herd behavior, much like investors everywhere these days. Funding is primarily deployed towards fads and popular trends, not necessarily towards what makes the most sense, even if sometimes the sensible manages to align with the popular. These days that means drug discovery platforms with a strong computational component and partial epigenetic reprogramming. But even in this environment, the path to true success is to work on important projects that few other people are touching. Be the champion for a potential solution to a tough, high-value, comparativel...
Source: Fight Aging! - March 8, 2024 Category: Research Authors: Reason Tags: Investment Source Type: blogs
A Way in Which Mitochondrial DNA Becomes Misplaced, Provoking Inflammation
Cells respond to the presence of DNA in the cytoplasm with inflammatory signaling, an evolved innate immune response that serves to protect against viral and bacterial infection. This becomes a problem when mitochondria become dysfunctional, as mitochondria contain their own small genome, the mitochondrial DNA. In the context of age-related mitochondrial dysfunction, and a number of other circumstances, fragments of mitochondrial DNA can find their way into the cell cytoplasm. The result is a link between mitochondrial dysfunction and the chronic inflammation of aging, though it remains unclear as to how much of this chara...
Source: Fight Aging! - March 8, 2024 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Arguing for Low Glutathione Levels to be Important in the Development of Parkinson's Disease
Glutathione is one of the more important cellular antioxidants. Delivery of glutathione via a range of mechanisms has been tested as a way to improve function in older individuals, with intriguing results in small clinical trials. The benefits include improved mitochondrial function and reduced inflammation. Delivery of antioxidants to mitochondria, where they can suppress the production of reactive oxygen species that takes place as a side-effect of the normal operation of these organelles, has been demonstrated to improve health and modestly slow aging in animal models. Unfortunately glutathione isn't orally bioavailable...
Source: Fight Aging! - March 7, 2024 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
