Reneo Pharmaceuticals Raises $50 Million to Develop Therapeutics to Treat Genetic Mitochondrial Diseases
SAN DIEGO, May 20, 2019 -- (Healthcare Sales & Marketing Network) -- Reneo Pharmaceuticals, a clinical stage pharmaceutical company, today announced that it has completed a $50 million Series A financing to develop therapies for diseases associated with d... Biopharmaceuticals, Venture Capital Reneo Pharmaceuticals, mitochondrial diseases (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - May 20, 2019 Category: Pharmaceuticals Source Type: news
Miro2 is a Parkin receptor for selective removal of damaged mitochondria
(Science China Press) Defects in mitophagy are linked to a variety of human diseases including Parkinson's and cardiac disorders. At present, how the damaged mitochondria are selectively recognized and targeted by Parkin is not fully understood. Miro2, a mitochondrial outer membrane protein, has been identified as a platform for Parkin translocation to damaged mitochondria. Miro2 senses both the depolarization and the Ca2+ release from mitochondria to ensure that only damaged mitochondria are targeted by Parkin for mitophagic clearance. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - May 16, 2019 Category: Biology Source Type: news
Biomarker may help identify men with prostate cancer at greater risk of tumor metastasis
(Elsevier) Ten percent of patients with prostate cancer develop locally invasive and metastatic disease, which increases the severity of the disease and likelihood of death and limits treatment options. A report in The American Journal of Pathology indicates that a significantly lower presence of syntaphilin (SNPH) -- a mitochondrial protein -- within the tumor's central core versus at the tumor's invasive outer edge, may identify patients at increased risk of metastasis. These patients may require more rigorous testing, surveillance, and treatment. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 9, 2019 Category: International Medicine & Public Health Source Type: news
Polycystin 2 regulates mitochondrial Ca2+ signaling, bioenergetics, and dynamics through mitofusin 2
Mitochondria and the endoplasmic reticulum (ER) have an intimate functional relationship due to tethering proteins that bring their membranes in close (~30 nm) apposition. One function of this interorganellar junction is to increase the efficiency of Ca2+ transfer into mitochondria, thus stimulating mitochondrial respiration. Here, we showed that the ER cation-permeant channel polycystin 2 (PC2) functions to reduce mitochondria-ER contacts. In cell culture models, PC2 knockdown led to a 50% increase in mitofusin 2 (MFN2) expression, an outer mitochondrial membrane GTPase. Live-cell super-resolution and electron microscopy ...
Source: Signal Transduction Knowledge Environment - May 6, 2019 Category: Science Authors: Kuo, I. Y., Brill, A. L., Lemos, F. O., Jiang, J. Y., Falcone, J. L., Kimmerling, E. P., Cai, Y., Dong, K., Kaplan, D. L., Wallace, D. P., Hofer, A. M., Ehrlich, B. E. Tags: STKE Research Articles Source Type: news
Environmental pollutants could impact cellular signs of aging
(American Chemical Society) Researchers have linked some environmental pollutants with diseases, a decreased life span and signs of premature aging, such as wrinkles and age spots. But can accelerated aging be detected at the cellular level in healthy people exposed to pollutants? Now, researchers in the ACS journal Environmental Science& Technology report that although pollutant exposure can affect two hallmarks of aging in people (mitochondrial DNA content and telomere length), the results are not so clear-cut. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - May 1, 2019 Category: International Medicine & Public Health Source Type: news
A Baby Was Born With DNA from 3 People. Here ’s How That’s Possible
Researchers at the Institute of Life in Athens, Greece announced that a healthy baby boy was born on Tuesday morning to a 32-year-old woman who had experienced several failed cycles of IVF.
The six-pound boy, who the doctors say in a statement is healthy, was born using a technique called maternal spindle transfer. In the procedure, the grouped-together DNA from a mother’s egg was removed and placed inside a donor egg from another woman, which had been emptied of its DNA. The donor’s egg with the mother’s genes was then fertilized and developed into an embryo that was transferred for pregnancy.
The techn...
Source: TIME: Health - April 11, 2019 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized Genetics Reproductive Health Source Type: news
Baby born with three-person DNA
Doctors used a donor egg to combat mother's mitochondrial disease Related items fromOnMedica Embryology proposals approved by MPs Charity asks Government to pay for NI abortions Women complain of 'confusing and contradictory' fertility advice MHRA tightens licence restrictions on valproate for women Colleges urge GPs to take on maternity care (Source: OnMedica Latest News)
Source: OnMedica Latest News - April 10, 2019 Category: UK Health Source Type: news
Visual defects and ageing - Sacc à SC, Cutolo CA, Rossi T.
Many diseases are related to age, among these neurodegeneration is particularly important. Alzheimer's disease Parkinson's and Glaucoma have many common pathogenic events including oxidative damage, Mitochondrial dysfunction, endothelial alterations and ch... (Source: SafetyLit)
Source: SafetyLit - March 24, 2019 Category: International Medicine & Public Health Tags: Age: Elder Adults Source Type: news
Gene behind long-recognized mitochondrial disease has highly varied effects
(Children's Hospital of Philadelphia) Mutations in the mitochondrial gene mt-ATP6, which encodes an essential part of the mitochondrial motor known as ATP synthase that generates cellular energy, are much more variable than previously thought. This prompts the need to develop more precise clinical tests that can better determine the course of treatment for patients affected by mitochondrial disorder. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 12, 2019 Category: International Medicine & Public Health Source Type: news
An existing drug may have therapeutic potential in mitochondrial disease
(Children's Hospital of Philadelphia) New preclinical findings from extensive cell and animal studies suggest that a drug already used for a rare kidney disease could benefit patients with some mitochondrial disorders -- complex conditions with severe energy deficiency for which no proven effective treatments exist. Future clinical research is needed to explore whether the drug, cysteamine bitartrate, will meaningfully benefit patients. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 26, 2019 Category: International Medicine & Public Health Source Type: news
What Is the Most Common Type of Cardiomyopathy?
Discussion
Barth syndrome is characterized by a dilated cardiomyopathy, proximal skeletal muscle weakness, neutropenia and short stature that usually presents at birth or soon after. It is a rare X-linked recessive disease process caused by mutations in the TAZ gene. The TAZ gene codes for tafazzin which alters cardiolipin in mitochondria. Characteristic facies can be seen especially in infancy including a tall and broad forehead, prominent chin and full cheeks, larger ears, and deep-set eyes. Most patients present at birth or soon afterwards but some may not until later in life. Life expectancy is reduced with many childr...
Source: PediatricEducation.org - February 25, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Sea slug study illuminates how mitochondria move
(Scripps Research Institute) Defects in the transport of cells' energy organelles are a suspected cause of diseases including Alzheimer's, ALS, Huntington's and Parkinson's. A new study reveals the genetics behind mitochondrial shifts. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 16, 2019 Category: International Medicine & Public Health Source Type: news
Manganese activates NLRP3 inflammasome signaling and propagates exosomal release of ASC in microglial cells
In this study, we examined whether Mn2+ activates the multiprotein NLRP3 inflammasome complex to promote neuroinflammation. Exposing activated mouse microglial cells to Mn2+ substantially augmented NLRP3 abundance, caspase-1 cleavage, and maturation of the inflammatory cytokine interleukin-1β (IL-1β). Exposure of mice to Mn2+ had similar effects in brain microglial cells. Furthermore, Mn2+ impaired mitochondrial ATP generation, basal respiratory rate, and spare capacity in microglial cells. These data suggest that Mn-induced mitochondrial defects drove the inflammasome signal amplification. We found that Mn induc...
Source: Signal Transduction Knowledge Environment - January 8, 2019 Category: Science Authors: Sarkar, S., Rokad, D., Malovic, E., Luo, J., Harischandra, D. S., Jin, H., Anantharam, V., Huang, X., Lewis, M., Kanthasamy, A., Kanthasamy, A. G. Tags: STKE Research Articles Source Type: news
An Experimental Procedure Could Help More Families Have Healthy Babies. But It ’s Not Allowed in the U.S.
When Noah Shulman was born a few days after Christmas 2016, his parents Kristelle and Evan had no reason to worry about him. The pregnancy went smoothly, and so did the birth.
But within a few days of taking his first breath, Noah began to struggle. He wasn’t feeding, so he started losing weight. He was also lethargic. Several pediatricians reassured the Shulmans that they were probably just overly sensitive to Noah’s symptoms because Kristelle is a nurse and Evan is a physician assistant–a case of first-time-parent-white-coat syndrome. “They kind of dismissed us as neurotic parents,” says Eva...
Source: TIME: Health - January 3, 2019 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized fertility Research Source Type: news
An Experimental Procedure Could Help More Families Have Healthy Babies. But It ’s Not Allowed in the U.S.
When Noah Shulman was born a few days after Christmas 2016, his parents Kristelle and Evan had no reason to worry about him. The pregnancy went smoothly, and so did the birth.
But within a few days of taking his first breath, Noah began to struggle. He wasn’t feeding, so he started losing weight. He was also lethargic. Several pediatricians reassured the Shulmans that they were probably just overly sensitive to Noah’s symptoms because Kristelle is a nurse and Evan is a physician assistant–a case of first-time-parent-white-coat syndrome. “They kind of dismissed us as neurotic parents,” says Eva...
Source: TIME: Science - January 3, 2019 Category: Science Authors: Alice Park Tags: Uncategorized fertility Research Source Type: news
