Harnessing GMNP-loaded BMSC-derived EVs to target miR-3064-5p via MEG3 overexpression: Implications for diabetic osteoporosis therapy in rats

In conclusion, GMNPs loaded with BMSC-EVs, through the delivery of MEG3 targeting miR-3064-5p, can effectively promote NR4A3 expression, activate the PINK1/Parkin pathway, and thereby enhance osteoblast proliferation and differentiation, offering a promising treatment for DO.PMID:38246512 | DOI:10.1016/j.cellsig.2024.111055

Source: Cellular Signalling - January 21, 2024 Category: Cytology Authors: Chen Xu Zhaodong Wang Ya Jun Liu Keyou Duan Jianzhong Guan Source Type: research