USP36-mediated PARP1 deubiquitination in doxorubicin-induced cardiomyopathy

In conclusion, these findings suggest that Dox promotes DIC progression by activating USP36-mediated PARP1 deubiquitination. This novel USP36/PARP1 axis may play a significant regulatory role in the pathogenesis of DIC.PMID:38307305 | DOI:10.1016/j.cellsig.2024.111070

Source: Cellular Signalling - February 2, 2024 Category: Cytology Authors: Dongchen Wang Zihao Jiang Junyan Kan Xiaomin Jiang Chang Pan Shijie You Ruirui Chang Juan Zhang Hongfeng Yang Linlin Zhu Yue Gu Source Type: research