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Human Adenovirus Surveillance — United States, 2003–2016
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - October 5, 2017 Category: American Health Source Type: news

Human Adenovirus Surveillance - United States, 2003-2016
Based on data from the National Adenovirus Type Reporting System, the most commonly reported types of HAdVs during 2003-2016 in the United States were HAdV types 1, 2, 3, 4, 7, and 14, which accounted for 85.5% (n = 1,283) of all types reported. (Source: PHPartners.org)
Source: PHPartners.org - October 5, 2017 Category: International Medicine & Public Health Source Type: news

New gene delivery approach could allow long-term persistence in proliferating cells
(Mary Ann Liebert, Inc./Genetic Engineering News) Researchers added a scaffold/matrix attachment region (S/MAR) to a conventional adeno-associated virus (AAV) vector used for gene transfer, and the modified vectors were able to establish colonies and maintain long-term transgene expression in HeLa cells. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 22, 2017 Category: Biology Source Type: news

Adenovirus Type 14 in Students With Influenza-Like Illness Adenovirus Type 14 in Students With Influenza-Like Illness
A better understanding of the genomic variants of human adenoviruses may help in the assessment and management of patients presenting with influenza-like illness.Emerging Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 12, 2017 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

New receptor found on scavenger cells
(University of Freiburg) Scientists demonstrate how adenovirus invades the immune system of mice. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - August 24, 2017 Category: Biology Source Type: news

NIAID herpesvirus study in mice leads to discovery of potential broad-spectrum antiviral
(NIH/National Institute of Allergy and Infectious Diseases) NIAID scientists studying herpes simplex virus infection have unexpectedly found that inhibiting a cellular enzyme complex, EZH2/1, suppresses viral infection. The researchers then demonstrated that EZH2/1 inhibitors also enhanced the cellular antiviral response in cultured cells and mice. They then showed that EZH2/1 inhibitors suppressed HSV infection, spread, and reactivation in mice and, in cell culture, suppressed human cytomegalovirus, adenovirus, and Zika virus infections. They suggest that EZH2/1 inhibitors have considerable potential as broad-spectrum ant...
Source: EurekAlert! - Medicine and Health - August 15, 2017 Category: International Medicine & Public Health Source Type: news

Notes from the Field: Epidemic Keratoconjunctivitis Outbreak Associated with Human Adenovirus Type 8 — U.S. Virgin Islands, June–November 2016
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - August 3, 2017 Category: American Health Source Type: news

Prednisone may improve effectiveness of AAV-based gene therapy by reducing immune response
(Mary Ann Liebert, Inc./Genetic Engineering News) A new study of gene transfer using adeno-associated virus (AAV)-based gene delivery into skeletal muscle of rhesus macaques showed that oral prednisone reduced immune responses to AAV that can weaken expression of the therapeutic transgene over time. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 9, 2017 Category: Biology Source Type: news

Homology Medicines Strengthens Manufacturing and Product Development Expertise with Appointment of Tim Kelly as Senior Vice President, Technical Operations
BEDFORD, Mass., May 31, 2017 -- (Healthcare Sales & Marketing Network) -- Homology Medicines, Inc., a genetic medicines company translating proprietary gene editing and gene therapy technologies into novel treatments for patients, announced today the appo... Biopharmaceuticals, Personnel Homology Medicines, adeno-associated virus (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - May 31, 2017 Category: Pharmaceuticals Source Type: news

What causes gene transfer to trigger T cell activation and exhaustion?
(Mary Ann Liebert, Inc./Genetic Engineering News) Researchers are beginning to gain a clearer understanding of how the immune system responds, in both a reactive and tolerant way, to gene therapy delivered using what has become the preferred gene delivery vector, adeno-associated viruses (AAV). A new review that takes a comprehensive look at both the AAV-mediated immune reactivation response to gene transfer and the role that regulatory and exhausted T cells play in the development of tolerance to AAV. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 27, 2017 Category: Global & Universal Source Type: news

Antibody delivery mediated by recombinant adeno-associated virus
(Bentham Science Publishers) Monoclonal antibody (mAb) based-therapies have revolutionized treatments of cancer and autoimmune diseases because of their specificity and limited toxicity (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 21, 2017 Category: Infectious Diseases Source Type: news

Membranes to remove viruses from drinking water
The'zwitterionic polymer hydrogel'repels the viruses from approaching and passing through the membrane. It contains both positive and negative charges and improves efficiency by weakening virus accumulation on the modified filter surface. The result was a significantly higher rate of removal of waterborne viruses, including human norovirus and adenovirus. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 19, 2017 Category: Science Source Type: news

Ben-Gurion U. researchers develop membranes that remove viruses from drinking water
(American Associates, Ben-Gurion University of the Negev) The 'zwitterionic polymer hydrogel' repels the viruses from approaching and passing through the membrane. It contains both positive and negative charges and improves efficiency by weakening virus accumulation on the modified filter surface. The result was a significantly higher rate of removal of waterborne viruses, including human norovirus and adenovirus. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 19, 2017 Category: Biology Source Type: news

Researchers improve vbectors for delivering hFVIII gene therapy to treat Hemophilia A
(Mary Ann Liebert, Inc./Genetic Engineering News) A new study examined 42 combinations of promoters and enhancers for human factor VIII (hFVIII) gene expression to identify the optimal adeno-associated virus (AAV)-based gene therapy delivery vector constructs to take forward into development. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 31, 2017 Category: Global & Universal Source Type: news

Will AAV vectors have a role in future novel gene therapy approaches?
(Mary Ann Liebert, Inc./Genetic Engineering News) Recombinant adeno-associated virus (rAAV) vectors for delivering therapeutic genes have demonstrated their safety in multiple diseases and clinical settings over the years and are a proven and effective tool that can be used to deliver new gene editing and replacement and genome modification technologies. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 20, 2017 Category: Biology Source Type: news

Ten million lives saved by 1962 breakthrough, study says
Nearly 200 million cases of polio, measles, mumps, rubella, varicella, adenovirus, rabies and hepatitis A -- and approximately 450,000 deaths from these diseases -- were prevented in the US alone between 1963 and 2015 by vaccination, researchers estimate. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 3, 2017 Category: Science Source Type: news

Ten million lives saved by 1962 breakthrough, study says
(University of Illinois at Chicago) Nearly 200 million cases of polio, measles, mumps, rubella, varicella, adenovirus, rabies and hepatitis A -- and approximately 450,000 deaths from these diseases -- were prevented in the US alone between 1963 and 2015 by vaccination, researchers estimate. The study is published in AIMS Public Health. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 3, 2017 Category: Global & Universal Source Type: news

AAV gene delivery vectors and cancer -- The debate continues
(Mary Ann Liebert, Inc./Genetic Engineering News) Overwhelming evidence from the biomedical literature shows that adeno-associated virus 2 (AAV2), a viral vector often used to deliver therapeutic genes, is not associated with cancer and, in fact, may protect against cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 23, 2017 Category: Cancer & Oncology Source Type: news

The smallest Cas9 genetic scissors (so far)
Scientists present the smallest member of the CRISPR-Cas9 family developed to date and show that it can fit inside adeno-associated viruses and mutate blindness-causing genes (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 21, 2017 Category: Science Source Type: news

The smallest Cas9 genetic scissors (so far)
(Institute for Basic Science) IBS scientists present the smallest member of the CRISPR-Cas9 family developed to date and show that it can fit inside adeno-associated viruses and mutate blindness-causing genes (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 21, 2017 Category: Global & Universal Source Type: news

Adenoviruses and the immune system join forces against cancer
(IDIBELL-Bellvitge Biomedical Research Institute) IDIBELL researchers have developed an oncolytic virus capable of redirecting the patient's immune system against their tumor cells. Their work may lead to the development of new therapeutic strategies for several types of cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 16, 2017 Category: Global & Universal Source Type: news

AAVP Biosystems Hires Mark Shapiro, M.D., Ph.D. as Chief Medical Officer
NEW YORK, Feb. 9, 2017 -- (Healthcare Sales & Marketing Network) -- AAVP Biosystems, Inc. (AAVP), a developmental stage targeted gene therapy company focused on the pursuit of a new therapy for cancer indications, is pleased to announce the hire of Mark S... Biopharmaceuticals, Oncology, Personnel AAVP Biosystems, Adeno-associated virus phage (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - February 9, 2017 Category: Pharmaceuticals Source Type: news

What is in the Differential Diagnosis of Fatigue?
Discussion Fatigue is a subjective feeling of decreased energy, tiredness or feeling of exhaustion. Lethargy is often used synonymously, but lethargy is a state of being drowsiness or sleepy, and implies mental status changes. Both can cause the person to be apathetic or less active. Fatigue is a common state that almost everyone experiences multiple times in his or her lifetime. For most people it is a relatively acute or short-term chronic problem, often with a relatively easily identifiable problem cause, such as inadequate sleep, acute illness, or overexertion. For some, it can be less readily identifiable such as dep...
Source: PediatricEducation.org - January 23, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Suffering the hacking cough plaguing Britain that lasts THREE weeks? It could get WORSE...
ADENOVIRUSES can affect the respiratory tract and cause an infection similar to the common cold, with a nasty cough - but antibiotics won ’t help people infected by the condition. (Source: Daily Express - Health)
Source: Daily Express - Health - January 12, 2017 Category: Consumer Health News Source Type: news

Suffering with a hacking cough? YOU could have the virus which can cause PNEUMONIA
ADENOVIRUSES can affect the respiratory tract and cause an infection similar to the common cold - but antibiotics won ’t help people infected by the condition. (Source: Daily Express - Health)
Source: Daily Express - Health - January 10, 2017 Category: Consumer Health News Source Type: news

Hacking cough plaguing Britain could be caused by virus that gives sufferers PNEUMONIA
GP surgeries across Britain have reported seeing a large number of patients with a nasty cough. Experts warn it could be caused by the adenovirus which can lead to pneumonia. (Source: the Mail online | Health)
Source: the Mail online | Health - January 9, 2017 Category: Consumer Health News Source Type: news

AGTC Appoints Michael Goldstein, M.D. as Chief Medical Officer
GAINESVILLE, Fla., and CAMBRIDGE, Mass., Nov. 17, 2016 -- (Healthcare Sales & Marketing Network) -- Applied Genetic Technologies Corporation (AGTC), a biotechnology company conducting human clinical trials of adeno-associated virus (AAV)-based gene therapi... Biopharmaceuticals, Personnel Applied Genetic Technologies, gene therapy (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 18, 2016 Category: Pharmaceuticals Source Type: news

DNAtrix begins Phase II trial of DNX-2401 and KEYTRUDA to treat recurrent glioblastoma
DNAtrix has announced that the first patients have been treated in a multicentre Phase 2 trial investigating its oncolytic adenovirus, DNX-2401, in combination with KEYTRUDA (pembrolizumab), Merck ’s anti-PD-1 therapy, in patients suffering with recur… (Source: Drug Development Technology)
Source: Drug Development Technology - November 3, 2016 Category: Pharmaceuticals Source Type: news

[Research Article] Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys
Zika virus (ZIKV) is responsible for a major ongoing epidemic in the Americas and has been causally associated with fetal microcephaly. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Here we demonstrate that three different vaccine platforms protect against ZIKV challenge in rhesus monkeys. A purified inactivated virus vaccine induced ZIKV-specific neutralizing antibodies and completely protected monkeys against ZIKV strains from both Brazil and Puerto Rico. Purified immunoglobulin from vaccinated monkeys also conferred passive protection in adoptive transfer studies. A ...
Source: ScienceNOW - September 8, 2016 Category: Science Authors: Peter Abbink Source Type: news

How immune response differs for natural AAV infection compared to AAV vector for gene transfer?
(Mary Ann Liebert, Inc./Genetic Engineering News) A new, long-term study examined the antibody response to natural infection with adeno-associated virus in chimpanzees for the purpose of characterizing the broad-based immune responses that could reduce the effectiveness of AAV vector-based gene delivery strategies. The study, which demonstrated the production of antibodies able to cross-neutralize multiple AAV serotypes, is published in Human Gene Therapy Clinical Development. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 10, 2016 Category: Global & Universal Source Type: news

7 Infections Athletes Could Get From Rio's Contaminated Waters
By: Rachael Rettner, Senior Writer Published: 08/03/2016 06:02 PM EDT on LiveScience The coastal waters around Rio de Janeiro, where many Olympic water competitions will soon take place, are reportedly teeming with harmful viruses and bacteria. So what illnesses might people catch if they swallow some of the water? If the water has been contaminated with raw sewage, as has been reported, then a number of common pathogens could be lurking there and make people ill, experts say. “There are many types of microbes in raw sewage that have the potential to cause human disease,” said Stephen Morse, a professor of epid...
Source: Science - The Huffington Post - August 5, 2016 Category: Science Source Type: news

Three vaccine approaches protect monkeys against Zika infection
(NIH/National Institute of Allergy and Infectious Diseases) Three different investigational Zika virus vaccine platforms--an inactivated virus vaccine, a DNA-based vaccine, and an adenovirus vector-based vaccine--protected against infection, induced immune responses, and produced no adverse side effects when tested in rhesus macaques challenged with the Zika virus, according to findings appearing August 4 in the journal Science. The results suggest that each of the three approaches holds promise for designing an effective Zika vaccine, according to the authors. (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - August 4, 2016 Category: Infectious Diseases Source Type: news

New study shows long-term safety of gene therapy in Parkinson's disease
( Mary Ann Liebert, Inc./Genetic Engineering News ) New safety data from a study of patients with advanced Parkinson's disease five years after gene transfer-mediated delivery of the neuroprotective factor neurturin directly to patients' brains reveal no serious adverse events related to the treatment. The encouraging long-term safety profile of the surgically administered adeno-associated virus (AAV2)-neurturin gene therapy is described in an article in Human Gene Therapy. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - July 27, 2016 Category: Biology Source Type: news

Clinical advances in gene therapy for central nervous system disorders
( Mary Ann Liebert, Inc./Genetic Engineering News ) The encouraging results of early stage clinical studies and the tremendous amount of preclinical data demonstrating the feasibility and promise of gene therapy to treat disorders of the central nervous system are driving new advances for the treatment of both genetic and acquired neurodegenerative diseases. Recent progress in therapeutic adeno-associated virus-mediated gene transfer strategies and prospects for the future are presented in a Review article in Human Gene Therapy. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - July 25, 2016 Category: Global & Universal Source Type: news

ONCOS-102 Mesothelioma Clinical Trial Promises Hope
Scandinavian-based Targovax launched the latest immunotherapy clinical trial for pleural mesothelioma, hoping it delivers a better way to treat patients with asbestos-related diseases. The randomized phase Ib/II trial evaluates the performance of ONCOS-102, an engineered human adenovirus designed to induce systemic, anti-tumor responses. Researchers are administering the immunotherapy drug as first-line therapy in combination with chemotherapy using pemetrexed and cisplatin. “Based on what we’ve seen in our first study of patients with various solid tumor types, which is good tolerance and response in a couple ...
Source: Asbestos and Mesothelioma News - July 12, 2016 Category: Environmental Health Authors: Walter Pacheco Tags: immunotherapy clinical trial immunotherapy for cancer mesothelioma mesothelioma clinical trials mesothelioma immunotherapy ONCOS 102 Source Type: news

Bristol-Myers Squibb and PsiOxus Therapeutics announce immuno-oncology clinical collaboration
-Bristol-Myers Squibb Company (NYSE: BMY) and PsiOxus Therapeutics, Ltd. (PsiOxus) today announced an exclusive clinical collaboration agreement to evaluate the safety, tolerability, and preliminary efficacy of PsiOxus' enadenotucirev, a systemically administered oncolytic adenovirus therapeutic, in combination with Bristol-Myers Squibb's Immuno-Oncology (I-O) agent Opdivo (nivolumab) to treat a range of tumor types in late-stage cancer patients. (Source: World Pharma News)
Source: World Pharma News - June 30, 2016 Category: Pharmaceuticals Tags: Featured Bristol-Myers Squibb Business and Industry Source Type: news

Homology Medicines Appoints James Warren, Ph.D. as Vice President of Manufacturing
Company Poised to Rapidly Advance Proprietary Next Generation Gene Editing Technology Using Novel Human Adeno-Associated Viruses LEXINGTON, Mass., June 6, 2016 -- (Healthcare Sales & Marketing Network) -- Homology Medicines, Inc., a recently formed gen... Biopharmaceuticals, PersonnelHomology Medicines, adeno-associated viruses, gene editing (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - June 6, 2016 Category: Pharmaceuticals Source Type: news

'Friendly' virus repairs damaged liver cells (but only in mice)
Conclusion This study showed it was possible to engineer and inject instructions that transform myofibroblasts into liver cells in mice with liver disease, which is quite a feat. Not all delivery mechanisms, called vectors, worked, but in those that did, the new liver cells looked normal, replaced some of the dying cells, and led to less damage due to collagen build up. Despite the alcoholism-related headline, the mice did not have alcohol-induced liver damage – although this is a major cause of liver damage in people. This study serves to prove this approach is feasible, and was successful in doing this. Researcher...
Source: NHS News Feed - June 3, 2016 Category: Consumer Health News Tags: Genetics/stem cells Lifestyle/exercise Medical practice Source Type: news

Does AAV-based gene delivery cause liver cancer? The debate heats up
(Mary Ann Liebert, Inc./Genetic Engineering News) Liver cancer can be triggered by mutations in cancer driver genes resulting from the insertion of adeno-associated virus vectors used to deliver therapeutic genes, although this tumor-inducing role of AAV remains highly controversial. Recently published evidence of AAV-associated hepatocellular carcinoma was previously re-examined in Human Gene Therapy. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - May 26, 2016 Category: Cancer & Oncology Source Type: news

Severe Infections With Human Adenovirus 7d in the USASevere Infections With Human Adenovirus 7d in the USA
Human adenovirus 7d was isolated from 2 adults with severe respiratory infections in Illinois. Does this mean genome type 7d could be circulating in the United States? Emerging Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - May 12, 2016 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

US researchers investigate gene therapy treatment for X-linked retinitis pigmentosa
Researchers from the University of Pennsylvania have revealed a new animal study data, which analyses the efficacy of an investigational, adeno-associated virus (AAV) vector gene therapy treatment for X-linked retinitis pigmentosa (XLRP). (Source: Pharmaceutical Technology)
Source: Pharmaceutical Technology - May 2, 2016 Category: Pharmaceuticals Source Type: news

Study examines safety, immune response of candidate Ebola vaccines
A phase 1 trial has been conducted to evaluate the tolerability and immunogenicity of two candidate Ebola vaccines, an adenovirus type 26 vector vaccine (Ad26.ZEBOV), and a modified Ankara vector vaccine (MVA-BN-Filo). (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 19, 2016 Category: Science Source Type: news

Study examines safety, immune response of candidate Ebola vaccines
(The JAMA Network Journals) In a study appearing in the April 19, 2016 issue of JAMA, Matthew D. Snape, F.R.C.P.C.H., M.D., of the University of Oxford, United Kingdom, and colleagues conducted a phase 1 trial to evaluate the tolerability and immunogenicity of two candidate Ebola vaccines, an adenovirus type 26 vector vaccine (Ad26.ZEBOV), and a modified Ankara vector vaccine (MVA-BN-Filo). (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 19, 2016 Category: Infectious Diseases Source Type: news

Timely Access: The Waiting Game
Innovation in pharma is in itself a complex and drawn-out process – where inspiration and perspiration merge over years to produce a novel compound or molecule that will benefit human health. Yet while this process has been increasingly streamlined as science and technology progresses, drug approval processes remain a painstaking process that can significantly delay access to groundbreaking and effective therapies. Despite the central role of industry in healthcare delivery, outcomes and development, innovation in the form of lifesaving or life-prolonging medicines is now being scuppered by lengthy gaps between marke...
Source: EyeForPharma - February 25, 2016 Category: Pharmaceuticals Authors: Danielle Barron Source Type: news

Adenovirus dampens host DNA damage response -- implications for control and cancer therapy
(PLOS) Adenoviruses (Ad) are everywhere, and while they pose limited threat in individuals with healthy immune systems, they cause significant disease burden in immunocompromised patients. A study published on Feb. 11 in PLOS Pathogens reports on a new mechanism by which the virus interferes with the host's ability to detect and eliminate viral intruders. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 11, 2016 Category: Cancer & Oncology Source Type: news

[Report] In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
In this study, adeno-associated virus was used to deliver the clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9 system to the mdx mouse model of DMD to remove the mutated exon 23 from the dystrophin gene. This includes local and systemic delivery to adult mice and systemic delivery to neonatal mice. Exon 23 deletion by CRISPR-Cas9 resulted in expression of the modified dystrophin gene, partial recovery of functional dystrophin protein in skeletal myofibers and cardiac muscle, improvement of muscle biochemistry, and significant enhancement of muscle force. This work establishes CRISPR-Cas9–...
Source: ScienceNOW - January 22, 2016 Category: Science Authors: Christopher E. Nelson Source Type: news

[Report] In vivo gene editing in dystrophic mouse muscle and muscle stem cells
In this study, we developed and tested a direct gene-editing approach to induce exon deletion and recover dystrophin expression in the mdx mouse model of DMD. Delivery by adeno-associated virus (AAV) of clustered regularly interspaced short palindromic repeats (CRISPR)–Cas9 endonucleases coupled with paired guide RNAs flanking the mutated Dmd exon23 resulted in excision of intervening DNA and restored the Dmd reading frame in myofibers, cardiomyocytes, and muscle stem cells after local or systemic delivery. AAV-Dmd CRISPR treatment partially recovered muscle functional deficiencies and generated a pool of endogenousl...
Source: ScienceNOW - January 22, 2016 Category: Science Authors: Mohammadsharif Tabebordbar Source Type: news

A Rapid, Cost-Effective Method to Prepare Recombinant Adeno-Associated Virus for Efficient Gene Transfer to the Developing Mouse Inner Ear
There is keen interest to define gene therapies aimed at restoration of auditory and vestibular function in the diseased or damaged mammalian inner ear. A persistent limitation of regenerative medical strategies that seek to correct or modify gene expression in the sensory epithelia of the inner ear involves efficacious delivery of a therapeutic genetic construct. Our approach is to define methodologies that enable fetal gene transfer to the developing mammalian inner ear in an effort to correct defective gene expression during formation of the sensory epithelia or during early postnatal life. Conceptually, the goal is to ...
Source: Springer protocols feed by Molecular Medicine - December 31, 2015 Category: Molecular Biology Source Type: news

Intussusception By The Numbers
Discussion Intussusception occurs when one segment of the gastrointestinal tract telescopes into an adjacent segment. The outer receiving segment of bowel is known as the intussuscipiens and the inner inverting segment is known as the intussusceptum. It occurs most often in children between 2 months to 5 years, with a peak incidence between 4-10 months. Males are more often affected than females by 3:2. It also occurs more often after abdominal operations particularly in the first 2 weeks. It is the second most common acute abdominal emergency in children after appendicitis. In adults ~80% have an underlying cause or lead ...
Source: PediatricEducation.org - September 7, 2015 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news