Studies find paediatric hepatitis cases in UK linked to infection with two viruses
Researchers from Glasgow& London suggest coinfection with 2 viruses —AAV2 and an adenovirus, may offer best explanation for recent cases of acute hepatitis in children. They postulate lockdown may have contributed due to lowered immunity& changes in patterns of virus circulation (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 28, 2022 Category: Consumer Health News Source Type: news

New needle-free nasal vaccine shows promise for COVID-19
New research shows that a needle-free mucosal bacteriophage (phage) T4-based COVID-19 vaccine is effective against SARS-CoV-2 infection. The findings were published in mBio, an open access journal of the American Society for Microbiology. In recent years, the Food and Drug Administration authorized mRNA- and adenovirus-based SARS-CoV-2 vaccines. (Source: World Pharma News)
Source: World Pharma News - July 28, 2022 Category: Pharmaceuticals Tags: Featured Research Research and Development Source Type: news

Little-known adeno-associated viruses may be key to unexplained hepatitis in kids, studies say
Scientists in the United Kingdom say they've found "strong circumstantial evidence" linking a mysterious type of sidekick virus called adeno-associated virus to unexplained cases of liver damage in children around the world. (Source: CNN.com - Health)
Source: CNN.com - Health - July 27, 2022 Category: Consumer Health News Source Type: news

Viral Infections and Gene Variant Are Linked to Child Hepatitis Cases
Some of the children were infected with adeno-associated virus 2 and shared a relatively uncommon gene variant, according to two small studies. (Source: NYT Health)
Source: NYT Health - July 26, 2022 Category: Consumer Health News Authors: Emily Anthes Tags: Children and Childhood Hepatitis Liver Viruses Research Genetics and Heredity World Health Organization Great Britain your-feed-healthcare Source Type: news

Little known adeno-associated viruses may be key to unexplained hepatitis in kids, studies say
Scientists in the United Kingdom say they've found "strong circumstantial evidence" linking an obscure type of sidekick virus called adeno-associated virus to unexplained cases of liver damage in children around the world. (Source: CNN.com - Health)
Source: CNN.com - Health - July 26, 2022 Category: Consumer Health News Source Type: news

Preprints Propose Constellation of Causes for Kids' Liver Disease
Two independent groups suggest the suite of recent unexplained hepatitis cases may stem from coinfection with an adeno-associated virus and a helper adeno- or herpesvirus, a duo which may be especially virulent in children with a particular genetic variant. (Source: The Scientist)
Source: The Scientist - July 25, 2022 Category: Science Tags: News & Opinion Source Type: news

Childhood hepatitis surge ‘probably linked to two common viruses’
Scientists say simultaneous infection with viruses may explain rise in cases, with 12 UK children requiring liver transplantsSimultaneous infection with two common viruses is thought to explain a recent surge inchildhood hepatitis cases, which has led to 12 UK children requiring liver transplants so far.Two research groups have detected high levels of adeno-associated virus 2 (AAV2) – a little-known virus not previously associated with human disease – in almost all of the affected British children they have tested. AAV2 is unable to replicate by itself but can do so in the presence of a second virus.Continue reading......
Source: Guardian Unlimited Science - July 25, 2022 Category: Science Authors: Linda Geddes Science correspondent Tags: Children's health Hepatitis B Hepatitis C Society Medical research Science Source Type: news

Mystery hepatitis cases in kids linked to unexpected viral suspect
Starting in April, young children in the United Kingdom and other countries suffering from mysterious cases of acute liver inflammation began to attract scientific —and media—attention. Most would recover, some after liver transplants, but a few died. Physicians could find no evidence in the children of the standard viruses that caused their hepatitis, but researchers homed in on an unexpected suspect: adenovirus, a family of cold-causing viruses common in kids. Now, a sweeping genetic search of these patients instead implicates another virus,  one thought to be completely harmless. In two independent,...
Source: ScienceNOW - July 25, 2022 Category: Science Source Type: news

Disinfection efficacy and mechanism of olanexidine gluconate against norovirus
Conclusions: This study suggests that olanexidine gluconate is a potential biological and environmental disinfectant against norovirus and adenovirus. (Source: Current Awareness Service for Health (CASH))
Source: Current Awareness Service for Health (CASH) - July 20, 2022 Category: Consumer Health News Source Type: news

Unexplained Acute Hepatitis in Children: More Evidence for Adenovirus 41
(MedPage Today) -- Two case series of children with unexplained acute hepatitis from the U.S. and U.K. pointed to human adenovirus viremia in most and strengthened the case for adenovirus 41 as a potential cause. Among nine such children seen... (Source: MedPage Today Gastroenterology)
Source: MedPage Today Gastroenterology - July 14, 2022 Category: Gastroenterology Source Type: news

Studies Probe Adenovirus Link to Childhood Hepatitis Cases
Two new papers add to the circumstantial evidence that a common childhood virus might be involved in the rare hepatitis cases, but many questions remain. (Source: NYT Health)
Source: NYT Health - July 13, 2022 Category: Consumer Health News Authors: Emily Anthes Tags: your-feed-science your-feed-health Hepatitis Children and Childhood Liver University of Alabama at Birmingham Birmingham (Ala) Great Britain Source Type: news

Link Between Pediatric Hepatitis and Adenovirus 41 Still Unclear Link Between Pediatric Hepatitis and Adenovirus 41 Still Unclear
90% of children in two new studies tested positive for the virus, but there was no evidence of viral infection in liver biopsies.Medscape Medical News (Source: Medscape General Surgery Headlines)
Source: Medscape General Surgery Headlines - July 13, 2022 Category: Surgery Tags: Infectious Diseases News Source Type: news

Cidofovir for Adenovirus-Related Hepatitis in Kids Clears Viremia Cidofovir for Adenovirus-Related Hepatitis in Kids Clears Viremia
Off-label use of cidofovir in children with acute liver failure and confirmed adenovirus infection cleared the virus or substantially reduced viremia in a small case series from London.Reuters Health Information (Source: Medscape Transplantation Headlines)
Source: Medscape Transplantation Headlines - July 1, 2022 Category: Transplant Surgery Tags: Pediatrics News Source Type: news

Interim Analysis of Acute Hepatitis of Unknown Etiology in Children Aged < 10 Years - United States, October 2021-June 2022
This report describes children diagnosed with hepatitis of unknown cause during October 2021 to June 2022. Preliminary analyses have not identified common exposures. (Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - June 30, 2022 Category: American Health Tags: Adenovirus Infection Children's Health Coronavirus [CoV] Hepatitis MMWR Morbidity & Mortality Weekly Report Public Health COVID-19 Source Type: news

Acute Hepatitis Cases in Children Show Declining Trend Acute Hepatitis Cases in Children Show Declining Trend
Experts update the latest case numbers for acute hepatitis in children and discuss possible factors that result in the disease, namely, adenovirus and COVID-19, either separately or together.Medscape Medical News (Source: Medscape Gastroenterology Headlines)
Source: Medscape Gastroenterology Headlines - June 24, 2022 Category: Gastroenterology Tags: Gastroenterology News Source Type: news