Antibodies Against Neuropeptides
Another Nod From Nature Scientific ReportsPublications referencing use of our antibodies continue to build. We are recognized for having potentNeuropeptide Antibodies.This most recent publication references ourGuinea Pig Substance-P Antibody: Khaled Abdallah, Francis Nadeau, Francis Bergeron, Sylvie Blouin, V éronique Blais, Kelly M. Bradbury, Christine L. Lavoie, Jean-Luc Parent;, Louis Gendron. (2018). Adeno-associated virus 2/9 delivery of Cre recombinase in mouse primary afferents. Scientific Reports volume 8, Article number: 7321 (2018) doi:10.1038/s41598-018-25626-yFigure: Distribution of the Cre-GFP in t...
Source: Neuromics - May 20, 2018 Category: Neuroscience Tags: Neuropeptide Antibodies Neuropeptides Substance P Antibodies Substance P Antibody Source Type: news

ONCOS-102 Mesothelioma Trial Moves Forward
Oncologists in Spain are recruiting patients for the randomized phase of the pleural mesothelioma clinical trial involving ONCOS-102, the promising immunotherapy vaccine. Optimism surrounding the trial stems from encouraging results obtained recently in the six-patient safety cohort used as a precautionary lead-in. The trial involves the vaccine in combination with standard-of-care chemotherapy for patients with inoperable disease. ONCOS-102 is a scientifically engineered adenovirus that is designed to activate a patient’s immune system to selectively target cancer cells. It is being developed by Targovax, a Scandina...
Source: Asbestos and Mesothelioma News - May 17, 2018 Category: Environmental Health Authors: Daniel King Source Type: news

Treatment of cancer could become possible with adenovirus
(Umea University) An international team of researchers led by professor Niklas Arnberg at Ume å University, shows that adenovirus binds to a specific type of carbohydrate that is overexpressed on certain types of cancer cells. The discovery opens up new opportunities for the development of virus-based cancer therapy. The study is published in the latest issue of the scientific journal " Proceedings of the National Academy of Sciences of USA " , PNAS PNAS April 19, 2018. 201716900 (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 20, 2018 Category: Biology Source Type: news

Notes from the Field: Fatalities Associated with Human Adenovirus Type 7 at a Substance Abuse Rehabilitation Facility — New Jersey, 2017
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - March 29, 2018 Category: American Health Source Type: news

Durham pharma pushing to fight a common cold virus that's deadly to some patients
For Durham-based Chimerix (Nasdaq: CMRX), fighting a virus known to cause the common cold is not a task it takes lightly.   That's because the company is currently setting up sites for a Phase 2 clinical trial of its lead antiviral drug brincidofovir for the treatment of adenovirus in pediatric transplant patients.  While the common virus is typically treated with over-the-counter medications, for patients with a w eakened immune system – such as pediatric transplant patients – it can be very… (Source: bizjournals.com Health Care:Physician Practices headlines)
Source: bizjournals.com Health Care:Physician Practices headlines - March 23, 2018 Category: American Health Authors: Jennifer Henderson Source Type: news

ZMapp antibody delivered by viral vector protects against Ebola infection
(Mary Ann Liebert, Inc./Genetic Engineering News) A new study comparing the effectiveness of individual ZMapp antibodies versus a cocktail of antibodies, administered to mice using recombinant adeno-associated virus (rAAV) delivery vectors, showed the ability to achieve 100% protection against infection by Ebola virus. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 9, 2018 Category: Biology Source Type: news

Adenovirus Type 4 Respiratory Infections Among Adults Adenovirus Type 4 Respiratory Infections Among Adults
Find out what there is to know about acute respiratory disease associated with human adenovirus type 4 among civilian adults.Emerging Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - March 8, 2018 Category: Consumer Health News Tags: Pulmonary Medicine Journal Article Source Type: news

Virus That Mimics Flu Poses a Health Threat
2 days ago ... by Michael Hedges, AARP Bulletin, March 2018|Comments: 0. influenza virus. BSIP/UIG via Getty Images. Bugs known as adenoviruses can cause symptoms similar to influenza: fever, headache, body aches and breathing problems. A virus that mimics the symptoms of the flu and may be just as dangerous  ... (Source: AARP.org News)
Source: AARP.org News - February 21, 2018 Category: American Health Source Type: news

Is It Influenza or Adenovirus? Is It Influenza or Adenovirus?
Some cases among the ongoing influenza-like illness outbreaks in the United States may be not caused by influenza virus but by a human adenovirus type 4 variant usually found in military settings.Medscape Medical News (Source: Medscape Internal Medicine Headlines)
Source: Medscape Internal Medicine Headlines - February 2, 2018 Category: Internal Medicine Tags: Infectious Diseases News Source Type: news

Stealth virus for cancer therapy
(University of Zurich) Scientists from the University of Zurich have redesigned an adenovirus for use in cancer therapy. To achieve this they developed a new protein shield that hides the virus and protects it from being eliminated. Adapters on the surface of the virus enable the reconstructed virus to specifically infect tumor cells. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 31, 2018 Category: Cancer & Oncology Source Type: news

New study shows severe toxicity with high-dose AAV9-based gene therapy in animal models
(Mary Ann Liebert, Inc./Genetic Engineering News) Researchers have described severe, life-threatening toxicity in monkeys and piglets given high doses of gene therapy delivered using an adeno-associated virus (AAV9) vector capable of accessing spinal cord neurons. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - January 30, 2018 Category: International Medicine & Public Health Source Type: news

KIF22 coordinates CAR and EGFR dynamics to promote cancer cell proliferation
The coxsackievirus and adenovirus receptor (CAR) is a transmembrane receptor that plays a key role in cell-cell adhesion. CAR is found in normal epithelial cells and is increased in abundance in various human tumors, including lung carcinomas. We investigated the potential mechanisms by which CAR contributes to cancer cell growth and found that depletion of CAR in human lung cancer cells reduced anchorage-independent growth, epidermal growth factor (EGF)–dependent proliferation, and tumor growth in vivo. EGF induced the phosphorylation of CAR and its subsequent relocalization to cell junctions through the activation ...
Source: Signal Transduction Knowledge Environment - January 30, 2018 Category: Science Authors: Pike, R., Ortiz-Zapater, E., Lumicisi, B., Santis, G., Parsons, M. Tags: STKE Research Articles Source Type: news

Doctors warn another flu-like deadly virus is going round
The adenovirus  — which often infects the airways and the intestinal tract — shares several symptoms with the flu, including congestion, sore throat, cough and fever, and can cause the common cold. (Source: the Mail online | Health)
Source: the Mail online | Health - January 29, 2018 Category: Consumer Health News Source Type: news

Civilians Now Getting Flu-Like Illness Afflicting Troops (CME/CE)
(MedPage Today) -- Human adenovirus type 4 found in adults in northeastern states (Source: MedPage Today Public Health)
Source: MedPage Today Public Health - January 11, 2018 Category: American Health Source Type: news

Rice University lab modifies nanoscale virus to deliver peptide drugs to cells, tissues
(Rice University) Rice University bioengineers develop programmable adeno-associated viruses that may be used to deliver peptide drugs. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - January 8, 2018 Category: Cancer & Oncology Source Type: news

' Promise of a Cure': Gene Therapy for Hemophilia A'Promise of a Cure': Gene Therapy for Hemophilia A
A gene-therapy-based approach reports that an adenovirus-based cassette was able to carry and deliver the culprit missing gene for hemophilia A: factor VIII.Medscape Medical News (Source: Medscape Medical News Headlines)
Source: Medscape Medical News Headlines - December 10, 2017 Category: Consumer Health News Tags: Hematology-Oncology News Source Type: news

Oncolytic Adenovirus Expressing BiTE Effectively Recruits T Cells to...
By expressing a secreted form of an EpCAM-specific BiTE molecule in the cancer cells it infects, a novel oncolytic virus both kills cells directly and induces a robust cytotoxic T cell response(PRWeb December 08, 2017)Read the full story at http://www.prweb.com/releases/2017/12/prweb14996998.htm (Source: PRWeb: Medical Pharmaceuticals)
Source: PRWeb: Medical Pharmaceuticals - December 8, 2017 Category: Pharmaceuticals Source Type: news

Third Respiratory Assay Now FDA Cleared on Hologic's New Panther Fusion(R) System
New Assay Detects Adenovirus, Human Metapneumovirus and Rhinovirus Modular Panels, Including Influenza, RSV and Paraflu, Increase Efficiency and Flexibility for the Laboratory MARLBOROUGH, Mass., Dec. 6, 2017 -- (Healthcare Sales & Marketing Network)... Diagnostics, FDA, Product Launch Hologic, Panther Fusion, Adenovirus, Metapneumovirus, Rhinovirus (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - December 6, 2017 Category: Pharmaceuticals Source Type: news

Human Adenovirus Surveillance -- United States, 2003-2016 Human Adenovirus Surveillance -- United States, 2003-2016
This report summarizes cases of human adenovirus voluntarily reported through the National Adenovirus Type Reporting System, which aims to determine patterns of circulation for individual HAdV types.Morbidity & Mortality Weekly Report (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - October 25, 2017 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

Human Adenovirus Surveillance — United States, 2003–2016
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - October 5, 2017 Category: American Health Source Type: news

Human Adenovirus Surveillance - United States, 2003-2016
Based on data from the National Adenovirus Type Reporting System, the most commonly reported types of HAdVs during 2003-2016 in the United States were HAdV types 1, 2, 3, 4, 7, and 14, which accounted for 85.5% (n = 1,283) of all types reported. (Source: PHPartners.org)
Source: PHPartners.org - October 5, 2017 Category: International Medicine & Public Health Source Type: news

New gene delivery approach could allow long-term persistence in proliferating cells
(Mary Ann Liebert, Inc./Genetic Engineering News) Researchers added a scaffold/matrix attachment region (S/MAR) to a conventional adeno-associated virus (AAV) vector used for gene transfer, and the modified vectors were able to establish colonies and maintain long-term transgene expression in HeLa cells. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - September 22, 2017 Category: Biology Source Type: news

Adenovirus Type 14 in Students With Influenza-Like Illness Adenovirus Type 14 in Students With Influenza-Like Illness
A better understanding of the genomic variants of human adenoviruses may help in the assessment and management of patients presenting with influenza-like illness.Emerging Infectious Diseases (Source: Medscape Today Headlines)
Source: Medscape Today Headlines - September 12, 2017 Category: Consumer Health News Tags: Infectious Diseases Journal Article Source Type: news

New receptor found on scavenger cells
(University of Freiburg) Scientists demonstrate how adenovirus invades the immune system of mice. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - August 24, 2017 Category: Biology Source Type: news

NIAID herpesvirus study in mice leads to discovery of potential broad-spectrum antiviral
(NIH/National Institute of Allergy and Infectious Diseases) NIAID scientists studying herpes simplex virus infection have unexpectedly found that inhibiting a cellular enzyme complex, EZH2/1, suppresses viral infection. The researchers then demonstrated that EZH2/1 inhibitors also enhanced the cellular antiviral response in cultured cells and mice. They then showed that EZH2/1 inhibitors suppressed HSV infection, spread, and reactivation in mice and, in cell culture, suppressed human cytomegalovirus, adenovirus, and Zika virus infections. They suggest that EZH2/1 inhibitors have considerable potential as broad-spectrum ant...
Source: EurekAlert! - Medicine and Health - August 15, 2017 Category: International Medicine & Public Health Source Type: news

Notes from the Field: Epidemic Keratoconjunctivitis Outbreak Associated with Human Adenovirus Type 8 — U.S. Virgin Islands, June–November 2016
(Source: CDC Morbidity and Mortality Weekly Report)
Source: CDC Morbidity and Mortality Weekly Report - August 3, 2017 Category: American Health Source Type: news

Prednisone may improve effectiveness of AAV-based gene therapy by reducing immune response
(Mary Ann Liebert, Inc./Genetic Engineering News) A new study of gene transfer using adeno-associated virus (AAV)-based gene delivery into skeletal muscle of rhesus macaques showed that oral prednisone reduced immune responses to AAV that can weaken expression of the therapeutic transgene over time. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - June 9, 2017 Category: Biology Source Type: news

Homology Medicines Strengthens Manufacturing and Product Development Expertise with Appointment of Tim Kelly as Senior Vice President, Technical Operations
BEDFORD, Mass., May 31, 2017 -- (Healthcare Sales & Marketing Network) -- Homology Medicines, Inc., a genetic medicines company translating proprietary gene editing and gene therapy technologies into novel treatments for patients, announced today the appo... Biopharmaceuticals, Personnel Homology Medicines, adeno-associated virus (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - May 31, 2017 Category: Pharmaceuticals Source Type: news

What causes gene transfer to trigger T cell activation and exhaustion?
(Mary Ann Liebert, Inc./Genetic Engineering News) Researchers are beginning to gain a clearer understanding of how the immune system responds, in both a reactive and tolerant way, to gene therapy delivered using what has become the preferred gene delivery vector, adeno-associated viruses (AAV). A new review that takes a comprehensive look at both the AAV-mediated immune reactivation response to gene transfer and the role that regulatory and exhausted T cells play in the development of tolerance to AAV. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - April 27, 2017 Category: Global & Universal Source Type: news

Antibody delivery mediated by recombinant adeno-associated virus
(Bentham Science Publishers) Monoclonal antibody (mAb) based-therapies have revolutionized treatments of cancer and autoimmune diseases because of their specificity and limited toxicity (Source: EurekAlert! - Infectious and Emerging Diseases)
Source: EurekAlert! - Infectious and Emerging Diseases - April 21, 2017 Category: Infectious Diseases Source Type: news

Membranes to remove viruses from drinking water
The'zwitterionic polymer hydrogel'repels the viruses from approaching and passing through the membrane. It contains both positive and negative charges and improves efficiency by weakening virus accumulation on the modified filter surface. The result was a significantly higher rate of removal of waterborne viruses, including human norovirus and adenovirus. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - April 19, 2017 Category: Science Source Type: news

Ben-Gurion U. researchers develop membranes that remove viruses from drinking water
(American Associates, Ben-Gurion University of the Negev) The 'zwitterionic polymer hydrogel' repels the viruses from approaching and passing through the membrane. It contains both positive and negative charges and improves efficiency by weakening virus accumulation on the modified filter surface. The result was a significantly higher rate of removal of waterborne viruses, including human norovirus and adenovirus. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - April 19, 2017 Category: Biology Source Type: news

Researchers improve vbectors for delivering hFVIII gene therapy to treat Hemophilia A
(Mary Ann Liebert, Inc./Genetic Engineering News) A new study examined 42 combinations of promoters and enhancers for human factor VIII (hFVIII) gene expression to identify the optimal adeno-associated virus (AAV)-based gene therapy delivery vector constructs to take forward into development. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 31, 2017 Category: Global & Universal Source Type: news

Will AAV vectors have a role in future novel gene therapy approaches?
(Mary Ann Liebert, Inc./Genetic Engineering News) Recombinant adeno-associated virus (rAAV) vectors for delivering therapeutic genes have demonstrated their safety in multiple diseases and clinical settings over the years and are a proven and effective tool that can be used to deliver new gene editing and replacement and genome modification technologies. (Source: EurekAlert! - Biology)
Source: EurekAlert! - Biology - March 20, 2017 Category: Biology Source Type: news

Ten million lives saved by 1962 breakthrough, study says
Nearly 200 million cases of polio, measles, mumps, rubella, varicella, adenovirus, rabies and hepatitis A -- and approximately 450,000 deaths from these diseases -- were prevented in the US alone between 1963 and 2015 by vaccination, researchers estimate. (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - March 3, 2017 Category: Science Source Type: news

Ten million lives saved by 1962 breakthrough, study says
(University of Illinois at Chicago) Nearly 200 million cases of polio, measles, mumps, rubella, varicella, adenovirus, rabies and hepatitis A -- and approximately 450,000 deaths from these diseases -- were prevented in the US alone between 1963 and 2015 by vaccination, researchers estimate. The study is published in AIMS Public Health. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - March 3, 2017 Category: Global & Universal Source Type: news

AAV gene delivery vectors and cancer -- The debate continues
(Mary Ann Liebert, Inc./Genetic Engineering News) Overwhelming evidence from the biomedical literature shows that adeno-associated virus 2 (AAV2), a viral vector often used to deliver therapeutic genes, is not associated with cancer and, in fact, may protect against cancer. (Source: EurekAlert! - Cancer)
Source: EurekAlert! - Cancer - February 23, 2017 Category: Cancer & Oncology Source Type: news

The smallest Cas9 genetic scissors (so far)
Scientists present the smallest member of the CRISPR-Cas9 family developed to date and show that it can fit inside adeno-associated viruses and mutate blindness-causing genes (Source: ScienceDaily Headlines)
Source: ScienceDaily Headlines - February 21, 2017 Category: Science Source Type: news

The smallest Cas9 genetic scissors (so far)
(Institute for Basic Science) IBS scientists present the smallest member of the CRISPR-Cas9 family developed to date and show that it can fit inside adeno-associated viruses and mutate blindness-causing genes (Source: EurekAlert! - Social and Behavioral Science)
Source: EurekAlert! - Social and Behavioral Science - February 21, 2017 Category: Global & Universal Source Type: news

Adenoviruses and the immune system join forces against cancer
(IDIBELL-Bellvitge Biomedical Research Institute) IDIBELL researchers have developed an oncolytic virus capable of redirecting the patient's immune system against their tumor cells. Their work may lead to the development of new therapeutic strategies for several types of cancer. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - February 16, 2017 Category: Global & Universal Source Type: news

AAVP Biosystems Hires Mark Shapiro, M.D., Ph.D. as Chief Medical Officer
NEW YORK, Feb. 9, 2017 -- (Healthcare Sales & Marketing Network) -- AAVP Biosystems, Inc. (AAVP), a developmental stage targeted gene therapy company focused on the pursuit of a new therapy for cancer indications, is pleased to announce the hire of Mark S... Biopharmaceuticals, Oncology, Personnel AAVP Biosystems, Adeno-associated virus phage (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - February 9, 2017 Category: Pharmaceuticals Source Type: news

What is in the Differential Diagnosis of Fatigue?
Discussion Fatigue is a subjective feeling of decreased energy, tiredness or feeling of exhaustion. Lethargy is often used synonymously, but lethargy is a state of being drowsiness or sleepy, and implies mental status changes. Both can cause the person to be apathetic or less active. Fatigue is a common state that almost everyone experiences multiple times in his or her lifetime. For most people it is a relatively acute or short-term chronic problem, often with a relatively easily identifiable problem cause, such as inadequate sleep, acute illness, or overexertion. For some, it can be less readily identifiable such as dep...
Source: PediatricEducation.org - January 23, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Suffering the hacking cough plaguing Britain that lasts THREE weeks? It could get WORSE...
ADENOVIRUSES can affect the respiratory tract and cause an infection similar to the common cold, with a nasty cough - but antibiotics won ’t help people infected by the condition. (Source: Daily Express - Health)
Source: Daily Express - Health - January 12, 2017 Category: Consumer Health News Source Type: news

Suffering with a hacking cough? YOU could have the virus which can cause PNEUMONIA
ADENOVIRUSES can affect the respiratory tract and cause an infection similar to the common cold - but antibiotics won ’t help people infected by the condition. (Source: Daily Express - Health)
Source: Daily Express - Health - January 10, 2017 Category: Consumer Health News Source Type: news

Hacking cough plaguing Britain could be caused by virus that gives sufferers PNEUMONIA
GP surgeries across Britain have reported seeing a large number of patients with a nasty cough. Experts warn it could be caused by the adenovirus which can lead to pneumonia. (Source: the Mail online | Health)
Source: the Mail online | Health - January 9, 2017 Category: Consumer Health News Source Type: news

AGTC Appoints Michael Goldstein, M.D. as Chief Medical Officer
GAINESVILLE, Fla., and CAMBRIDGE, Mass., Nov. 17, 2016 -- (Healthcare Sales & Marketing Network) -- Applied Genetic Technologies Corporation (AGTC), a biotechnology company conducting human clinical trials of adeno-associated virus (AAV)-based gene therapi... Biopharmaceuticals, Personnel Applied Genetic Technologies, gene therapy (Source: HSMN NewsFeed)
Source: HSMN NewsFeed - November 18, 2016 Category: Pharmaceuticals Source Type: news

DNAtrix begins Phase II trial of DNX-2401 and KEYTRUDA to treat recurrent glioblastoma
DNAtrix has announced that the first patients have been treated in a multicentre Phase 2 trial investigating its oncolytic adenovirus, DNX-2401, in combination with KEYTRUDA (pembrolizumab), Merck ’s anti-PD-1 therapy, in patients suffering with recur… (Source: Drug Development Technology)
Source: Drug Development Technology - November 3, 2016 Category: Pharmaceuticals Source Type: news

[Research Article] Protective efficacy of multiple vaccine platforms against Zika virus challenge in rhesus monkeys
Zika virus (ZIKV) is responsible for a major ongoing epidemic in the Americas and has been causally associated with fetal microcephaly. The development of a safe and effective ZIKV vaccine is therefore an urgent global health priority. Here we demonstrate that three different vaccine platforms protect against ZIKV challenge in rhesus monkeys. A purified inactivated virus vaccine induced ZIKV-specific neutralizing antibodies and completely protected monkeys against ZIKV strains from both Brazil and Puerto Rico. Purified immunoglobulin from vaccinated monkeys also conferred passive protection in adoptive transfer studies. A ...
Source: ScienceNOW - September 8, 2016 Category: Science Authors: Peter Abbink Source Type: news

How immune response differs for natural AAV infection compared to AAV vector for gene transfer?
(Mary Ann Liebert, Inc./Genetic Engineering News) A new, long-term study examined the antibody response to natural infection with adeno-associated virus in chimpanzees for the purpose of characterizing the broad-based immune responses that could reduce the effectiveness of AAV vector-based gene delivery strategies. The study, which demonstrated the production of antibodies able to cross-neutralize multiple AAV serotypes, is published in Human Gene Therapy Clinical Development. (Source: EurekAlert! - Medicine and Health)
Source: EurekAlert! - Medicine and Health - August 10, 2016 Category: Global & Universal Source Type: news

7 Infections Athletes Could Get From Rio's Contaminated Waters
By: Rachael Rettner, Senior Writer Published: 08/03/2016 06:02 PM EDT on LiveScience The coastal waters around Rio de Janeiro, where many Olympic water competitions will soon take place, are reportedly teeming with harmful viruses and bacteria. So what illnesses might people catch if they swallow some of the water? If the water has been contaminated with raw sewage, as has been reported, then a number of common pathogens could be lurking there and make people ill, experts say. “There are many types of microbes in raw sewage that have the potential to cause human disease,” said Stephen Morse, a professor of epid...
Source: Science - The Huffington Post - August 5, 2016 Category: Science Source Type: news