Neutrophil extracellular traps promote gastric cancer cell metastasis via the NAT10-mediated N4-acetylcytidine modification of SMYD2
Cell Signal. 2023 Dec 16:111014. doi: 10.1016/j.cellsig.2023.111014. Online ahead of print.ABSTRACTIt has been reported that the formation of neutrophil extracellular traps (NETs) is associated with cancer metastasis. The current study aimed to explore the effects of NETs on gastric cancer (GC) cell metastasis and uncover their underlying mechanism. NETs were measured in the plasma of patients with GC. Then, GC cells were treated with NETs to assess cell viability, migration, and invasion using cell counting kit 8 and Transwell assay, The liver metastasis and xenograft tumor mouse models were established to assess tumor gr...
Source: Cellular Signalling - December 18, 2023 Category: Cytology Authors: Donghui Liu Xiaoyao Yang Xuyao Wang Source Type: research
The impact of LncRNA-SOX2-OT/let-7c-3p/SKP2 Axis on head and neck squamous cell carcinoma progression: Insights from bioinformatics analysis and experimental validation
CONCLUSIONS: Our study establishes the critical SOX2-OT/let-7c-3p/SKP2 axis as a pivotal regulator of HNSCC tumorigenesis and metastasis.PMID:38110167 | DOI:10.1016/j.cellsig.2023.111018 (Source: Cellular Signalling)
Source: Cellular Signalling - December 18, 2023 Category: Cytology Authors: Di Wang Xue Zhao Shuang Li Haixian Guo Shaonan Li Dan Yu Source Type: research
Neutrophil extracellular traps promote gastric cancer cell metastasis via the NAT10-mediated N4-acetylcytidine modification of SMYD2
Cell Signal. 2023 Dec 16:111014. doi: 10.1016/j.cellsig.2023.111014. Online ahead of print.ABSTRACTIt has been reported that the formation of neutrophil extracellular traps (NETs) is associated with cancer metastasis. The current study aimed to explore the effects of NETs on gastric cancer (GC) cell metastasis and uncover their underlying mechanism. NETs were measured in the plasma of patients with GC. Then, GC cells were treated with NETs to assess cell viability, migration, and invasion using cell counting kit 8 and Transwell assay, The liver metastasis and xenograft tumor mouse models were established to assess tumor gr...
Source: Cellular Signalling - December 18, 2023 Category: Cytology Authors: Donghui Liu Xiaoyao Yang Xuyao Wang Source Type: research
Targeting the prostate tumor microenvironment by plant-derived natural products
Cell Signal. 2023 Dec 15:111011. doi: 10.1016/j.cellsig.2023.111011. Online ahead of print.ABSTRACTProstate cancer is among the most common malignancies for men, with limited therapy options for last stages of the tumor. There are some different options for treatment and control of prostate tumor growth. However, targeting some specific molecules and cells within tumors has been attracted interests in recent years. The tumor microenvironment (TME) has an important role in the initiation of various malignancies, which can also expand the progression of tumor and facilitate invasion of malignant cells. By regulating immune r...
Source: Cellular Signalling - December 17, 2023 Category: Cytology Authors: Jiacheng Wu Hao Ji Tiantian Li Haifeng Guo HaiFei Xu Jinfeng Zhu Jiale Tian Mingde Gao Xiaolin Wang Aihua Zhang Source Type: research
Targeting the prostate tumor microenvironment by plant-derived natural products
Cell Signal. 2023 Dec 15:111011. doi: 10.1016/j.cellsig.2023.111011. Online ahead of print.ABSTRACTProstate cancer is among the most common malignancies for men, with limited therapy options for last stages of the tumor. There are some different options for treatment and control of prostate tumor growth. However, targeting some specific molecules and cells within tumors has been attracted interests in recent years. The tumor microenvironment (TME) has an important role in the initiation of various malignancies, which can also expand the progression of tumor and facilitate invasion of malignant cells. By regulating immune r...
Source: Cellular Signalling - December 17, 2023 Category: Cytology Authors: Jiacheng Wu Hao Ji Tiantian Li Haifeng Guo HaiFei Xu Jinfeng Zhu Jiale Tian Mingde Gao Xiaolin Wang Aihua Zhang Source Type: research
Integration of proteomics and metabolomics reveals energy and metabolic alterations induced by glucokinase (GCK) partial inactivation in hepatocytes
In conclusion, GCK knockdown reduced TCA cycle flux and oxidative stress in hepatocytes by influencing the levels of key transcription factors and enzymes, providing a comprehensive understanding of the effects of GCK partial inactivation on liver metabolism and molecular mechanisms.PMID:38092300 | DOI:10.1016/j.cellsig.2023.111009 (Source: Cellular Signalling)
Source: Cellular Signalling - December 13, 2023 Category: Cytology Authors: Ziyan Xie Jieying Liu Ting Xie Peng Liu Xiangyi Hui Qian Zhang Xinhua Xiao Source Type: research
NOX4 alleviates breast cancer cell aggressiveness by co-ordinating mitochondrial turnover through PGC1 α/Drp1 axis
This study investigates the complex molecular mechanism by which NADPH oxidase 4 (NOX4), a major ROS producer in mitochondria, affects the aggressiveness of luminal and triple-negative breast cancer cells (TNBCs). We found that NOX4 expression was differentially regulated in luminal and TNBC cells, with a positive correlation to their epithelial characteristics. Time dependent analysis revealed that TNBCs exhibits higher steady-state ROS levels than luminal cells, but NOX4 silencing increased ROS levels in luminal breast cancer cells and enhanced their ability to migrate and invade. In contrast, NOX4 over expression in TNB...
Source: Cellular Signalling - December 13, 2023 Category: Cytology Authors: Deepali Bhadane Dinisha Kamble Mangesh Deval Subhajit Das Sandhya Sitasawad Source Type: research
Integration of proteomics and metabolomics reveals energy and metabolic alterations induced by glucokinase (GCK) partial inactivation in hepatocytes
In conclusion, GCK knockdown reduced TCA cycle flux and oxidative stress in hepatocytes by influencing the levels of key transcription factors and enzymes, providing a comprehensive understanding of the effects of GCK partial inactivation on liver metabolism and molecular mechanisms.PMID:38092300 | DOI:10.1016/j.cellsig.2023.111009 (Source: Cellular Signalling)
Source: Cellular Signalling - December 13, 2023 Category: Cytology Authors: Ziyan Xie Jieying Liu Ting Xie Peng Liu Xiangyi Hui Qian Zhang Xinhua Xiao Source Type: research
NOX4 alleviates breast cancer cell aggressiveness by co-ordinating mitochondrial turnover through PGC1 α/Drp1 axis
This study investigates the complex molecular mechanism by which NADPH oxidase 4 (NOX4), a major ROS producer in mitochondria, affects the aggressiveness of luminal and triple-negative breast cancer cells (TNBCs). We found that NOX4 expression was differentially regulated in luminal and TNBC cells, with a positive correlation to their epithelial characteristics. Time dependent analysis revealed that TNBCs exhibits higher steady-state ROS levels than luminal cells, but NOX4 silencing increased ROS levels in luminal breast cancer cells and enhanced their ability to migrate and invade. In contrast, NOX4 over expression in TNB...
Source: Cellular Signalling - December 13, 2023 Category: Cytology Authors: Deepali Bhadane Dinisha Kamble Mangesh Deval Subhajit Das Sandhya Sitasawad Source Type: research
Integration of proteomics and metabolomics reveals energy and metabolic alterations induced by glucokinase (GCK) partial inactivation in hepatocytes
In conclusion, GCK knockdown reduced TCA cycle flux and oxidative stress in hepatocytes by influencing the levels of key transcription factors and enzymes, providing a comprehensive understanding of the effects of GCK partial inactivation on liver metabolism and molecular mechanisms.PMID:38092300 | DOI:10.1016/j.cellsig.2023.111009 (Source: Cellular Signalling)
Source: Cellular Signalling - December 13, 2023 Category: Cytology Authors: Ziyan Xie Jieying Liu Ting Xie Peng Liu Xiangyi Hui Qian Zhang Xinhua Xiao Source Type: research
NOX4 alleviates breast cancer cell aggressiveness by co-ordinating mitochondrial turnover through PGC1 α/Drp1 axis
This study investigates the complex molecular mechanism by which NADPH oxidase 4 (NOX4), a major ROS producer in mitochondria, affects the aggressiveness of luminal and triple-negative breast cancer cells (TNBCs). We found that NOX4 expression was differentially regulated in luminal and TNBC cells, with a positive correlation to their epithelial characteristics. Time dependent analysis revealed that TNBCs exhibits higher steady-state ROS levels than luminal cells, but NOX4 silencing increased ROS levels in luminal breast cancer cells and enhanced their ability to migrate and invade. In contrast, NOX4 over expression in TNB...
Source: Cellular Signalling - December 13, 2023 Category: Cytology Authors: Deepali Bhadane Dinisha Kamble Mangesh Deval Subhajit Das Sandhya Sitasawad Source Type: research
Integration of proteomics and metabolomics reveals energy and metabolic alterations induced by glucokinase (GCK) partial inactivation in hepatocytes
In conclusion, GCK knockdown reduced TCA cycle flux and oxidative stress in hepatocytes by influencing the levels of key transcription factors and enzymes, providing a comprehensive understanding of the effects of GCK partial inactivation on liver metabolism and molecular mechanisms.PMID:38092300 | DOI:10.1016/j.cellsig.2023.111009 (Source: Cellular Signalling)
Source: Cellular Signalling - December 13, 2023 Category: Cytology Authors: Ziyan Xie Jieying Liu Ting Xie Peng Liu Xiangyi Hui Qian Zhang Xinhua Xiao Source Type: research
NOX4 alleviates breast cancer cell aggressiveness by co-ordinating mitochondrial turnover through PGC1 α/Drp1 axis
This study investigates the complex molecular mechanism by which NADPH oxidase 4 (NOX4), a major ROS producer in mitochondria, affects the aggressiveness of luminal and triple-negative breast cancer cells (TNBCs). We found that NOX4 expression was differentially regulated in luminal and TNBC cells, with a positive correlation to their epithelial characteristics. Time dependent analysis revealed that TNBCs exhibits higher steady-state ROS levels than luminal cells, but NOX4 silencing increased ROS levels in luminal breast cancer cells and enhanced their ability to migrate and invade. In contrast, NOX4 over expression in TNB...
Source: Cellular Signalling - December 13, 2023 Category: Cytology Authors: Deepali Bhadane Dinisha Kamble Mangesh Deval Subhajit Das Sandhya Sitasawad Source Type: research
LncRNA MAGI2-AS3 inhibites tumor progression by up-regulating STAM via interacting with miR-142-3p in clear cell renal cell carcinoma
Cell Signal. 2024 Jan;113:110954. doi: 10.1016/j.cellsig.2023.110954. Epub 2023 Oct 28.ABSTRACTRevealing the role of non-coding RNAs (ncRNAs) in inducing dysregulated pathological responses to external signals may identify therapeutic targets for inhibiting the progression of clear cell renal cell carcinoma (ccRCC). Non-coding RNAs belong to a class of RNA molecules that do not encode proteins but possess diverse biological functions, playing essential roles in the occurrence and development of metastatic and proliferative tumors. To investigate the impact of the upstream interaction between miR-142-3p and lncRNA MAGI2-AS3...
Source: Cellular Signalling - December 12, 2023 Category: Cytology Authors: Riwei Yang Zude Chen Shan Ao Leqi Liang Zugen Chen Xiaolu Duan Guohua Zeng Tuo Deng Source Type: research
Kindlin-2 regulates colonic cancer stem-like cells survival and self-renewal via Wnt/ β-catenin mediated pathway
CONCLUSION: Our study delineates the isoform-specific activity of Kindlin-2 in regulating Colonic CSC. Isoform-specific targeting of Kindlin-2 may be a novel strategy to tackle this devastating disease.PMID:38084837 | DOI:10.1016/j.cellsig.2023.110953 (Source: Cellular Signalling)
Source: Cellular Signalling - December 12, 2023 Category: Cytology Authors: Ravi Prakash Yadav Somesh Baranwal Source Type: research
