E3 ubiquitin ligase CHIP interacts with transferrin receptor 1 for degradation and promotes cell proliferation through inhibiting ferroptosis in hepatocellular carcinoma
Cell Signal. 2024 Mar 21:111148. doi: 10.1016/j.cellsig.2024.111148. Online ahead of print.ABSTRACTHepatocellular carcinoma (HCC) is the major form of liver malignancy with high incidence and mortality. Identifying novel biomarkers and understanding regulatory mechanisms underlying the development and progression of HCC are critical for improving diagnosis, treatment and patient outcomes. Carboxyl terminus of Hsc-70-interacting protein (CHIP) is a well-described U-box-type E3 ubiquitin ligase which promotes the ubiquitination and degradation of numerous tumor-associated proteins. Recent studies have shown that CHIP can pla...
Source: Cellular Signalling - March 23, 2024 Category: Cytology Authors: Miaomiao Shao Kangwei Qi Lanxin Wang Xiaoxuan Yu Qingyu Zhang Long Yu Lan Wang Caiting Yang Lu Fan Source Type: research
Unraveling the mechanism in l-Caldesmon regulating the osteogenic differentiation of PDLSCs: An innovative perspective
Cell Signal. 2024 Mar 19:111147. doi: 10.1016/j.cellsig.2024.111147. Online ahead of print.ABSTRACTMaxillofacial bone defect is one of the common symptoms in maxillofacial, which affects the function and aesthetics of maxillofacial region. Periodontal ligament stem cells (PDLSCs) are extensively used in bone tissue engineering. The mechanism that regulates the osteogenic differentiation of PDLSCs remains not fully elucidated. Previous studies demonstrated that l-Caldesmon (l-Cad, or Cald1) might be involved in the osteogenic differentiation of PDLSCs. Here, the mechanism by which Cald1 regulates the osteogenic differentiat...
Source: Cellular Signalling - March 21, 2024 Category: Cytology Authors: Yuejia Li Ziyi Mei Pingmeng Deng Sha Zhou Aizhuo Qian Xiya Zhang Jie Li Source Type: research
Unraveling the mechanism in l-Caldesmon regulating the osteogenic differentiation of PDLSCs: An innovative perspective
Cell Signal. 2024 Mar 19:111147. doi: 10.1016/j.cellsig.2024.111147. Online ahead of print.ABSTRACTMaxillofacial bone defect is one of the common symptoms in maxillofacial, which affects the function and aesthetics of maxillofacial region. Periodontal ligament stem cells (PDLSCs) are extensively used in bone tissue engineering. The mechanism that regulates the osteogenic differentiation of PDLSCs remains not fully elucidated. Previous studies demonstrated that l-Caldesmon (l-Cad, or Cald1) might be involved in the osteogenic differentiation of PDLSCs. Here, the mechanism by which Cald1 regulates the osteogenic differentiat...
Source: Cellular Signalling - March 21, 2024 Category: Cytology Authors: Yuejia Li Ziyi Mei Pingmeng Deng Sha Zhou Aizhuo Qian Xiya Zhang Jie Li Source Type: research
MZB1 regulates cellular proliferation, mitochondrial dysfunction, and inflammation and targets the PI3K-Akt signaling pathway in acute pancreatitis
CONCLUSIONS: AP cells and tissues exhibited markedly elevated levels of MZB1 expression compared to their healthy counterparts. MZB1 overexpression promoted proliferation and supressed apoptosis, mitochondrial dysfunction, and inflammation in pancreatic cells through the positive regulation of the PI3K-Akt signaling pathway.PMID:38508349 | DOI:10.1016/j.cellsig.2024.111143 (Source: Cellular Signalling)
Source: Cellular Signalling - March 20, 2024 Category: Cytology Authors: Mengtao Xu Yong Feng Xuelian Xiang Li Liu Guodu Tang Source Type: research
The PIEZO1/miR-155-5p/GDF6/SMAD2/3 signaling axis is involved in inducing the occurrence and progression of osteoarthritis under excessive mechanical stress
CONCLUSION: GDF6 overexpression or miR-155-5p inhibition could attenuate overloading-induced chondrocyte senescence and OA through the PIEZO1-miR-155-5p-GDF6-SMAD2/3 signaling pathway. Our study provides a new therapeutic target for the treatment of overloading-induced OA.PMID:38508350 | DOI:10.1016/j.cellsig.2024.111142 (Source: Cellular Signalling)
Source: Cellular Signalling - March 20, 2024 Category: Cytology Authors: Chaoren Qin Yan Feng Zhaowei Yin Changjiang Wang Rui Yin Yang Li Kai Chen Tianqi Tao Kaibin Zhang Yiqiu Jiang Jianchao Gui Source Type: research
MZB1 regulates cellular proliferation, mitochondrial dysfunction, and inflammation and targets the PI3K-Akt signaling pathway in acute pancreatitis
CONCLUSIONS: AP cells and tissues exhibited markedly elevated levels of MZB1 expression compared to their healthy counterparts. MZB1 overexpression promoted proliferation and supressed apoptosis, mitochondrial dysfunction, and inflammation in pancreatic cells through the positive regulation of the PI3K-Akt signaling pathway.PMID:38508349 | DOI:10.1016/j.cellsig.2024.111143 (Source: Cellular Signalling)
Source: Cellular Signalling - March 20, 2024 Category: Cytology Authors: Mengtao Xu Yong Feng Xuelian Xiang Li Liu Guodu Tang Source Type: research
The PIEZO1/miR-155-5p/GDF6/SMAD2/3 signaling axis is involved in inducing the occurrence and progression of osteoarthritis under excessive mechanical stress
CONCLUSION: GDF6 overexpression or miR-155-5p inhibition could attenuate overloading-induced chondrocyte senescence and OA through the PIEZO1-miR-155-5p-GDF6-SMAD2/3 signaling pathway. Our study provides a new therapeutic target for the treatment of overloading-induced OA.PMID:38508350 | DOI:10.1016/j.cellsig.2024.111142 (Source: Cellular Signalling)
Source: Cellular Signalling - March 20, 2024 Category: Cytology Authors: Chaoren Qin Yan Feng Zhaowei Yin Changjiang Wang Rui Yin Yang Li Kai Chen Tianqi Tao Kaibin Zhang Yiqiu Jiang Jianchao Gui Source Type: research
Microglial uptake of hADSCs-Exo mitigates neuroinflammation in ICH
This study aims to investigate the role of hADSCs-Exo in ICH and its underlying mechanism involving miRNA-mediated regulation of formyl peptide receptor 1 (FPR1). Flow cytometry was used to identify hADSCs and extract exosomes. Transmission electron microscopy and Western blot were performed to confirm the characteristics of the exosomes. In vitro experiments were conducted to explore the uptake of hADSCs-Exo by microglia cells and their impact on inflammatory responses. In vivo, an ICH mouse model was established, and the therapeutic effects of hADSCs-Exo were evaluated through neurological function scoring, histological ...
Source: Cellular Signalling - March 18, 2024 Category: Cytology Authors: Lanqing Zhao Jinwei Li Source Type: research
Microglial uptake of hADSCs-Exo mitigates neuroinflammation in ICH
This study aims to investigate the role of hADSCs-Exo in ICH and its underlying mechanism involving miRNA-mediated regulation of formyl peptide receptor 1 (FPR1). Flow cytometry was used to identify hADSCs and extract exosomes. Transmission electron microscopy and Western blot were performed to confirm the characteristics of the exosomes. In vitro experiments were conducted to explore the uptake of hADSCs-Exo by microglia cells and their impact on inflammatory responses. In vivo, an ICH mouse model was established, and the therapeutic effects of hADSCs-Exo were evaluated through neurological function scoring, histological ...
Source: Cellular Signalling - March 18, 2024 Category: Cytology Authors: Lanqing Zhao Jinwei Li Source Type: research
WDR4 promotes HCC pathogenesis through N < sup > 7 < /sup > -methylguanosine by regulating and interacting with METTL1
CONCLUSIONS: WDR4 may contribute to HCC pathogenesis by interacting with and regulating the expression of METTL1 to synergistically modulate the m7G modification of target mRNAs in tumor cells.PMID:38493882 | DOI:10.1016/j.cellsig.2024.111145 (Source: Cellular Signalling)
Source: Cellular Signalling - March 17, 2024 Category: Cytology Authors: Rui Dong Chuanxu Wang Bo Tang Yayu Cheng Xuehui Peng Xiaomin Yang Bing Ni Jing Li Source Type: research
The regulatory role of miRNA and lncRNA on autophagy in diabetic nephropathy
Cell Signal. 2024 Mar 15:111144. doi: 10.1016/j.cellsig.2024.111144. Online ahead of print.ABSTRACTDiabetic nephropathy (DN) is a serious complication of diabetes that causes glomerular sclerosis and end-stage renal disease, leading to ascending morbidity and mortality in diabetic patients. Excessive accumulation of aberrantly modified proteins or damaged organelles, such as advanced glycation end-products, dysfunctional mitochondria, and inflammasomes is associated with the pathogenesis of DN. As one of the main degradation pathways, autophagy recycles toxic substances to maintain cellular homeostasis and autophagy dysreg...
Source: Cellular Signalling - March 17, 2024 Category: Cytology Authors: Siming Yu Yue Li Xinxin Lu Zehui Han Chunsheng Li Xingxing Yuan Dandan Guo Source Type: research
WDR4 promotes HCC pathogenesis through N < sup > 7 < /sup > -methylguanosine by regulating and interacting with METTL1
CONCLUSIONS: WDR4 may contribute to HCC pathogenesis by interacting with and regulating the expression of METTL1 to synergistically modulate the m7G modification of target mRNAs in tumor cells.PMID:38493882 | DOI:10.1016/j.cellsig.2024.111145 (Source: Cellular Signalling)
Source: Cellular Signalling - March 17, 2024 Category: Cytology Authors: Rui Dong Chuanxu Wang Bo Tang Yayu Cheng Xuehui Peng Xiaomin Yang Bing Ni Jing Li Source Type: research
The regulatory role of miRNA and lncRNA on autophagy in diabetic nephropathy
Cell Signal. 2024 Mar 15:111144. doi: 10.1016/j.cellsig.2024.111144. Online ahead of print.ABSTRACTDiabetic nephropathy (DN) is a serious complication of diabetes that causes glomerular sclerosis and end-stage renal disease, leading to ascending morbidity and mortality in diabetic patients. Excessive accumulation of aberrantly modified proteins or damaged organelles, such as advanced glycation end-products, dysfunctional mitochondria, and inflammasomes is associated with the pathogenesis of DN. As one of the main degradation pathways, autophagy recycles toxic substances to maintain cellular homeostasis and autophagy dysreg...
Source: Cellular Signalling - March 17, 2024 Category: Cytology Authors: Siming Yu Yue Li Xinxin Lu Zehui Han Chunsheng Li Xingxing Yuan Dandan Guo Source Type: research
Circ_0007534 promotes cholangiocarcinoma stemness and resistance to anoikis through DDX3X-mediated positive feedback regulation of parental gene DDX42
In conclusion, this study sheds light on the pivotal role and molecular mechanism of circ_0007534 in the development of CCA, offering potential new targets for early diagnosis and treatment.PMID:38492624 | DOI:10.1016/j.cellsig.2024.111141 (Source: Cellular Signalling)
Source: Cellular Signalling - March 16, 2024 Category: Cytology Authors: Sidi Liu Canghai Guan Xiangjun Sha Xin Gao Xinlei Zou Chengru Yang Xinmiao Zhang Xiangyu Zhong Xingming Jiang Source Type: research
Exploration of gut microbiome and inflammation: A review on key signalling pathways
Cell Signal. 2024 Mar 16;118:111140. doi: 10.1016/j.cellsig.2024.111140. Online ahead of print.ABSTRACTThe gut microbiome, a crucial component of the human system, is a diverse collection of microbes that belong to the gut of human beings as well as other animals. These microbial communities continue to coexist harmoniously with their host organisms and perform various functions that affect the host's general health. Each person's gut microbiota has a unique makeup. The gut microbiota is well acknowledged to have a part in the local as well as systemic inflammation that underlies a number of inflammatory disorders (e.g., a...
Source: Cellular Signalling - March 16, 2024 Category: Cytology Authors: Manisha Nigam Kanchan Devi Henrique D M Coutinho Abhay Prakash Mishra Source Type: research
