Low-intensity pulsed ultrasound (LIPUS) promotes skeletal muscle regeneration by regulating PGC-1 α/AMPK/GLUT4 pathways in satellite cells/myoblasts
Cell Signal. 2024 Feb 13;117:111097. doi: 10.1016/j.cellsig.2024.111097. Online ahead of print.ABSTRACTLow-Intensity Pulsed Ultrasound (LIPUS) holds therapeutic potential in promoting skeletal muscle regeneration, a biological process mediated by satellite cells and myoblasts. Despite their central roles in regeneration, the detailed mechanistic of LIPUS influence on satellite cells and myoblasts are not fully underexplored. In the current investigation, we administrated LIPUS treatment to injured skeletal muscles and C2C12 myoblasts over five consecutive days. Muscle samples were collected on days 6 and 30 post-injury for...
Source: Cellular Signalling - February 14, 2024 Category: Cytology Authors: Huimin Duan Shujie Chen Xudong Mai Liping Fu Liujing Huang Lanling Xiao Miaomiao Liao Hong Chen Gang Liu Liwei Xie Source Type: research
Promoter A1312C mutation leads to microRNA-7 downregulation in human non-small cell lung cancer
In this study, based on clinical sample analysis, we found that the downregulated expression of miR-7 was dominantly attributed to the decreased level of pri-miR-7-2 in human NSCLC. Furthermore, there were four site mutations in the miR-7-2 promoter sequence. Notably, among these four sites, mutation at -1312 locus (A → C, termed as A1312C mutation) was dominate, and A1312C mutation further led to decreased expression of miR-7 in human NSCLC cells, accompanied with elevated transduction of NDUFA4/ERK/AKT signaling pathway. Mechanistically, homeobox A5 (HOXA5) is the key transcription factors regulating miR-7 expression i...
Source: Cellular Signalling - February 12, 2024 Category: Cytology Authors: Shipeng Chen Hui Wang Mengmeng Guo Xu Zhao Jing Yang Longqing Chen Juanjuan Zhao Chao Chen Ya Zhou Lin Xu Source Type: research
IL-36 antagonism blunts the proliferation and migration of oral squamous cell carcinoma cells
Cell Signal. 2024 Feb 10;117:111096. doi: 10.1016/j.cellsig.2024.111096. Online ahead of print.ABSTRACTIL-36 is known to mediate inflammation and fibrosis. Nevertheless, IL-36 signalling axis has also been implicated in cancer, although understanding of exact contribution of IL-36 to cancer progression is very limited, partly due to existence of multiple IL-36 ligands with agonistic and antagonistic function. Here we explored the role of IL-36 in oral squamous cell carcinoma (OSCC). Firstly, we analyzed expression of IL-36 ligands and receptor and found that the expression of IL-36γ was significantly higher in head and ne...
Source: Cellular Signalling - February 12, 2024 Category: Cytology Authors: Zihui Li Xiaoxin Zhang Ke Li Fuyan Li Jiahao Kou Yuhan Wang Xiaoyue Wei Yawei Sun Yue Jing Yuxian Song QiuYa Yu Haijia Yu Shuai Wang Shi Chen Yangtin Wang Simin Xie Xiangyang Zhu Yifan Zhan Guowen Sun Yanhong Ni Source Type: research
Hypoxia-inducible PRMT2 addiction in glioblastomas
Cell Signal. 2024 Feb 8;117:111094. doi: 10.1016/j.cellsig.2024.111094. Online ahead of print.ABSTRACTHypoxia-inducible transcription factors (HIFs) are key transcription factors for cellular response to low oxygen levels. However, the specific mediators responsible for activating downstream transcription are not well characterized. We previously identified Protein Arginine methyltransferase 2 (PRMT2), a highly expressed methyltransferase in glioblastoma multiforme, as a transcription co-activator. And we established a connection between PRMT2-mediated histone H3R8 asymmetric methylation (H3R8me2a) and transcription activa...
Source: Cellular Signalling - February 10, 2024 Category: Cytology Authors: Feng Dong Xiaoyu Sun Jiacheng Su Qian Li You He Wei Li Baofeng Wang Bo Wang Guogang Xu Xudong Wu Source Type: research
Circ-FOXO3 inhibits triple-negative breast cancer growth and metastasis via regulating WHSC1-H3K36me2-Zeb2 axis
In this study, we found that circ-FOXO3 was dramatically downregulated in TNBC tissues and blood samples from patients with TNBC. Notably, low circ-FOXO3 expression in TNBC tissues and bloods was associated with lymph node metastasis and unfavorable outcomes in patients with TNBC. Overexpression of circ-FOXO3 significantly inhibited the growth, invasion, and metastasis of TNBC cells both in vitro and in vivo. Moreover, we demonstrated that circ-FOXO3 was predominantly expressed in the cytoplasm and directly interacted with Wolf-Hirschhorn syndrome candidate 1 (WHSC1), thereby inhibiting WHSC1 nuclear localization and activ...
Source: Cellular Signalling - February 10, 2024 Category: Cytology Authors: Danyang Chen Shanshan Zeng Huisi Qiu Mingqiang Yang Xin Lin Xinwu Lv Pan Li Shaojuan Weng Siyue Kou Kai Luo Zongcai Liu Yanmei Yi Hao Liu Source Type: research
Single-cell RNA sequencing reveals the MIF-ACKR3 receptor-ligand interaction between iCAFs and tumor cells in esophageal squamous cell carcinoma
CONCLUSIONS: This study exposes the features of the tumor microenvironment of ESCC via scRNA-seq and examines the dynamics of various cellular subpopulations, thus facilitating the identification of future therapeutic targets for ESCC.PMID:38336189 | DOI:10.1016/j.cellsig.2024.111093 (Source: Cellular Signalling)
Source: Cellular Signalling - February 9, 2024 Category: Cytology Authors: Jialu Liang Kai Lei Ruihao Liang Jing Huang Binhua Tan Huayue Lin Minghui Wang Source Type: research
Multifaceted antineoplastic curative potency of novel water-soluble methylimidazole-based oxidovanadium (IV) complex against triple negative mammary carcinoma
Cell Signal. 2024 Feb 7;117:111089. doi: 10.1016/j.cellsig.2024.111089. Online ahead of print.ABSTRACTA bunch of complexes harboring vanadium as metal centers have been reported to exhibit a wide array of antineoplastic properties that come under non‑platinum metallodrug series and emerge to offer alternative therapeutic strategies from the mechanistic behaviors of platinum-drugs. Though antineoplastic activities of vanado-complexes have been documented against several animal and xenografted human cancers, the definite mechanism of action is yet to unveil. In present study, a novel water soluble 1-methylimidazole substit...
Source: Cellular Signalling - February 8, 2024 Category: Cytology Authors: Noyel Ghosh Samhita De Nikhil Ranjan Pramanik Parames C Sil Source Type: research
SENP3 attenuates foam cell formation by deSUMOylating NLRP3 in macrophages stimulated with ox-LDL
Cell Signal. 2024 Feb 6;117:111092. doi: 10.1016/j.cellsig.2024.111092. Online ahead of print.ABSTRACTSUMO-specific protease 3 (SENP3) participates in the removal of SUMOylation and maintains the balance of the SUMO system, which ensures normal functioning of substrates and cellular activities. In the present study, we found that SENP3 expression was significantly reduced in ox-LDL-stimulated macrophages. SENP3 overexpression suppressed and SENP3 knockdown promoted macrophage foam cell formation. Moreover, SENP3 inhibited cholesterol uptake, CD36 expression, and NOD-like receptor thermal protein domain-associated protein 3...
Source: Cellular Signalling - February 8, 2024 Category: Cytology Authors: Jiaojiao Chen Xuan Sun Yuan Liu Yuze Zhang Min Zhao Luyao Shao Source Type: research
METTL3 modification of circStk4 affects mouse glomerular messangial cell autophagy, proliferation and apotosis by regulating miR-133a-3p/C1 axis
CONCLUSION: m6A modification of circStk4 mediated by METTL3 influenced circStk4 expression and impacted autophagy, proliferation and apoptosis in GMCs via the miR-133a-3p/C1 axis. This discovery introduces a novel therapeutic approach for CGN treatment.PMID:38331014 | DOI:10.1016/j.cellsig.2024.111091 (Source: Cellular Signalling)
Source: Cellular Signalling - February 8, 2024 Category: Cytology Authors: Xiujuan Qin Huiyu Chen Wenjia Zheng Xiaoli Zhu Jiarong Gao Source Type: research
Rap1GAP exacerbates myocardial infarction by regulating the AMPK/SIRT1/NF- κB signaling pathway
In conclusion, our results suggest that Rap1GAP promotes MI by modulating the AMPK/SIRT1/NF-κB signaling pathway and that Rap1GAP may be a therapeutic target for MI treatment in the future.PMID:38320624 | DOI:10.1016/j.cellsig.2024.111080 (Source: Cellular Signalling)
Source: Cellular Signalling - February 6, 2024 Category: Cytology Authors: Tiantian Shan Xiaoying Li Wenzhi Xie Shaoqin Wang Yan Gao Yan Zheng Guohai Su Ying Li Zhuo Zhao Source Type: research
The IGF2BP2-lncRNA TRPC7-AS1 axis promotes hepatocellular carcinoma cell proliferation and invasion
Cell Signal. 2024 Feb 4:111078. doi: 10.1016/j.cellsig.2024.111078. Online ahead of print.ABSTRACTHepatocellular carcinoma(HCC) is one of the most common tumors in the world. Human insulin-like growth factor 2(IGF2) mRNA binding protein 2(IGF2BP2) plays an important role in the progression of hepatocellular carcinoma. Additionally, long non-coding RNA(lncRNA) has been confirmed as a key regulator of hepatocellular carcinoma occurrence. However, the function of TRPC7-AS1 has not been verified in hepatocellular carcinoma. The research results revealed that high IGF2BP2 expression was associated with a decreased survival rate...
Source: Cellular Signalling - February 6, 2024 Category: Cytology Authors: Xu Zhang Zilin Li Huizong Nie Yue Huang Jingyang Du Yiling Xi Chaoqin Guo Mingshan Mu Xiangyu Li Xiaoliang Zheng Qiuran Xu Dongsheng Huang Linglan Tu Liyan Cheng Source Type: research
FATP2 activates PI3K/Akt/mTOR pathway by inhibiting ATF3 and promotes the occurrence and development of bladder cancer
This study delved into the function of FATP2 in BLCA through a succession of experiments in vivo and in vitro, employing techniques as quantitative real-time polymerase chain reaction (qRT-PCR), RNA sequencing, transwell assays, immunofluorescence, western blot,and others to dissect its mechanistic actions. The findings revealed that an oncogenic function is executed by FATP2 in bladder cancer, significantly impacting the proliferation and migration capabilities, thereby affecting the prognosis of BLCA patients. Furthermore, A suppression that relies on both time and concentration of BLCA proliferation and migration, trigg...
Source: Cellular Signalling - February 5, 2024 Category: Cytology Authors: Ming Jiang Ru Chen Bing Hu Situ Xiong Sheng Li Bin Fu Xiaoqiang Liu Source Type: research
TMEM16A inhibits renal tubulointerstitial fibrosis via Wnt/ β-catenin signaling during hypertension nephropathy
CONCLUSION: In angiotensin II (Ang II)-induced hypertensive nephropathy, TMEM16A was identified as a key player inhibiting the detrimental changes in renal tubules, suggesting a potential avenue for mitigating renal damage in hypertensive nephropathy.PMID:38316267 | DOI:10.1016/j.cellsig.2024.111088 (Source: Cellular Signalling)
Source: Cellular Signalling - February 5, 2024 Category: Cytology Authors: Feng Wang Yiqing Zhang Min Gao Xuelin Zeng Source Type: research
Machine learning combined with single-cell analysis reveals predictive capacity and immunotherapy response of T cell exhaustion-associated lncRNAs in uterine corpus endometrial carcinoma
CONCLUSIONS: The association between TEXLs and UCEC was methodically elucidated by our investigation. A stable pTEXLs risk prediction model and a diagnosis model for UCEC were also established.PMID:38311301 | DOI:10.1016/j.cellsig.2024.111077 (Source: Cellular Signalling)
Source: Cellular Signalling - February 4, 2024 Category: Cytology Authors: Feng Jiang Ziyu Tao Yun Zhang Xiaoyan Xie Yunlei Bao Yifang Hu Jingxin Ding Chuyan Wu Source Type: research
Drp1-mediated mitochondrial fission promotes pulmonary fibrosis progression through the regulation of lipid metabolic reprogramming by ROS/HIF-1 α
CONCLUSION: In PF, inhibition of Drp1 can prevent mitochondrial fission in fibroblasts and regulate lipid metabolism reprogramming through ROS/HIF-1α; thus, fibroblast activation was inhibited, alleviating the progression of PF.PMID:38311302 | DOI:10.1016/j.cellsig.2024.111075 (Source: Cellular Signalling)
Source: Cellular Signalling - February 4, 2024 Category: Cytology Authors: Zhongkai Tong Xuekui Du Ying Zhou Fangxue Jing JiangPo Ma Yingying Feng Saiyun Lou Qiong Wang Zhaoxing Dong Source Type: research
