Identification and validation of ferroptosis-related genes for diabetic retinopathy
This study sheds new light on the pathogenesis of DR.PMID:38084838 | DOI:10.1016/j.cellsig.2023.110955 (Source: Cellular Signalling)
Source: Cellular Signalling - December 12, 2023 Category: Cytology Authors: Changjin Lu Qingxia Lan Qiuyue Song Xiaoyi Yu Source Type: research
Prolyl isomerase Pin1 promotes autophagy and cancer cell viability through activating FoxO3 signalling
Cell Signal. 2024 Jan;113:110940. doi: 10.1016/j.cellsig.2023.110940. Epub 2023 Oct 30.ABSTRACTPin1-directed prolyl isomerization is a central common oncogenic mechanism to drive tumorigenic processes. However, the role of Pin1 in cellular autophagy is still poorly understood. Here we report that pharmacological inhibition of Pin1 decreased the formation of autophagosome/autolysosomes upon nutrient starvation. Inhibition of Pin1 reduced, whereas forced expression of Pin1 increased, the level of LC3 and viability of U2OS and PANC-1 cells. Pin1 could augment the accumulation of LC3 upon chloroquine treatment, while chloroqui...
Source: Cellular Signalling - December 12, 2023 Category: Cytology Authors: Juan Long Jiaxin Wang Yuanyuan Dong Jian Yang Gang Xie Ying Tong Source Type: research
Immunogenicity of cancer cells: An overview
Cell Signal. 2024 Jan;113:110952. doi: 10.1016/j.cellsig.2023.110952. Epub 2023 Oct 29.ABSTRACTThe immune system assumes a pivotal role in the organism's capacity to discern and obliterate malignant cells. The immunogenicity of a cancer cell pertains to its proficiency in inciting an immunological response. The prowess of immunogenicity stands as a pivotal determinant in the triumph of formulating immunotherapeutic methodologies. Immunotherapeutic strategies include immune checkpoint inhibitors, chimeric antigen receptor (CAR) T-cell therapy, and on vaccines. Immunogenic cell death (ICD) epitomizes a form of cellular demis...
Source: Cellular Signalling - December 12, 2023 Category: Cytology Authors: Tanya Singh Madhuri Bhattacharya Anil Kumar Mavi Anita Gulati None Rakesh Naresh Kumar Sharma Sonal Gaur Umesh Kumar Source Type: research
Rev-erb α attenuates diabetic myocardial injury through regulation of ferroptosis
Cell Signal. 2023 Dec 10:111006. doi: 10.1016/j.cellsig.2023.111006. Online ahead of print.ABSTRACTDiabetes is a widespread disease that threatens the life and health of human beings, and diabetic cardiomyopathy (DCM) is one of the major complications of diabetic patients. The pathological mechanisms of DCM are complex, including inflammation, endoplasmic reticulum stress, and oxidative stress that have been reported previously. Although recent studies suggested that ferroptosis is also involved in the progression of DCM, the exact mechanism remains unclear. Rev-erbα cardiac conditional knockout mice were generated and ty...
Source: Cellular Signalling - December 12, 2023 Category: Cytology Authors: Hao Tian Qin Huang Yonghong Xiong Zhongyuan Xia Source Type: research
LncRNA MAGI2-AS3 inhibites tumor progression by up-regulating STAM via interacting with miR-142-3p in clear cell renal cell carcinoma
Cell Signal. 2024 Jan;113:110954. doi: 10.1016/j.cellsig.2023.110954. Epub 2023 Oct 28.ABSTRACTRevealing the role of non-coding RNAs (ncRNAs) in inducing dysregulated pathological responses to external signals may identify therapeutic targets for inhibiting the progression of clear cell renal cell carcinoma (ccRCC). Non-coding RNAs belong to a class of RNA molecules that do not encode proteins but possess diverse biological functions, playing essential roles in the occurrence and development of metastatic and proliferative tumors. To investigate the impact of the upstream interaction between miR-142-3p and lncRNA MAGI2-AS3...
Source: Cellular Signalling - December 12, 2023 Category: Cytology Authors: Riwei Yang Zude Chen Shan Ao Leqi Liang Zugen Chen Xiaolu Duan Guohua Zeng Tuo Deng Source Type: research
Kindlin-2 regulates colonic cancer stem-like cells survival and self-renewal via Wnt/ β-catenin mediated pathway
CONCLUSION: Our study delineates the isoform-specific activity of Kindlin-2 in regulating Colonic CSC. Isoform-specific targeting of Kindlin-2 may be a novel strategy to tackle this devastating disease.PMID:38084837 | DOI:10.1016/j.cellsig.2023.110953 (Source: Cellular Signalling)
Source: Cellular Signalling - December 12, 2023 Category: Cytology Authors: Ravi Prakash Yadav Somesh Baranwal Source Type: research
Identification and validation of ferroptosis-related genes for diabetic retinopathy
This study sheds new light on the pathogenesis of DR.PMID:38084838 | DOI:10.1016/j.cellsig.2023.110955 (Source: Cellular Signalling)
Source: Cellular Signalling - December 12, 2023 Category: Cytology Authors: Changjin Lu Qingxia Lan Qiuyue Song Xiaoyi Yu Source Type: research
Prolyl isomerase Pin1 promotes autophagy and cancer cell viability through activating FoxO3 signalling
Cell Signal. 2024 Jan;113:110940. doi: 10.1016/j.cellsig.2023.110940. Epub 2023 Oct 30.ABSTRACTPin1-directed prolyl isomerization is a central common oncogenic mechanism to drive tumorigenic processes. However, the role of Pin1 in cellular autophagy is still poorly understood. Here we report that pharmacological inhibition of Pin1 decreased the formation of autophagosome/autolysosomes upon nutrient starvation. Inhibition of Pin1 reduced, whereas forced expression of Pin1 increased, the level of LC3 and viability of U2OS and PANC-1 cells. Pin1 could augment the accumulation of LC3 upon chloroquine treatment, while chloroqui...
Source: Cellular Signalling - December 12, 2023 Category: Cytology Authors: Juan Long Jiaxin Wang Yuanyuan Dong Jian Yang Gang Xie Ying Tong Source Type: research
Immunogenicity of cancer cells: An overview
Cell Signal. 2024 Jan;113:110952. doi: 10.1016/j.cellsig.2023.110952. Epub 2023 Oct 29.ABSTRACTThe immune system assumes a pivotal role in the organism's capacity to discern and obliterate malignant cells. The immunogenicity of a cancer cell pertains to its proficiency in inciting an immunological response. The prowess of immunogenicity stands as a pivotal determinant in the triumph of formulating immunotherapeutic methodologies. Immunotherapeutic strategies include immune checkpoint inhibitors, chimeric antigen receptor (CAR) T-cell therapy, and on vaccines. Immunogenic cell death (ICD) epitomizes a form of cellular demis...
Source: Cellular Signalling - December 12, 2023 Category: Cytology Authors: Tanya Singh Madhuri Bhattacharya Anil Kumar Mavi Anita Gulati None Rakesh Naresh Kumar Sharma Sonal Gaur Umesh Kumar Source Type: research
The role and mechanism of HIF-1 α-mediated glypican-3 secretion in hypoxia-induced tumor progression in hepatocellular carcinoma
CONCLUSION: Hypoxia promoted secretion of exosomal GPC3 through the activation of HIF-1α. GPC3-deficient exosomes inhibited the proliferation, migration and EMT of HCC cells via the Wnt/β-catenin signaling pathway, and suppressed the angiogenic potential of HUVECs. This provided a novel understanding of the role of exosomal GPC3 in HCC progression.PMID:38081444 | DOI:10.1016/j.cellsig.2023.111007 (Source: Cellular Signalling)
Source: Cellular Signalling - December 11, 2023 Category: Cytology Authors: Pingfeng Wang Kun Tong Ying Li Xuejie Li Yuan Zhang Jiangxue Gu Panwei Lei Shirong Yan Pei Hu Source Type: research
Inhibition of SIRT7 promotes STAT1 activation and STAT1-dependent signaling in hepatocellular carcinoma
In conclusion, our data shed light on the intricate interplay between ubiquitination, STAT1, SIRT7, and Smurf1, elucidating their impact on STAT1-related signaling. These insights contribute to a more comprehensive understanding of the molecular mechanisms involved in STAT1 regulation and suggest potential avenues for the development of targeted therapies against cancer.PMID:38070755 | DOI:10.1016/j.cellsig.2023.111005 (Source: Cellular Signalling)
Source: Cellular Signalling - December 9, 2023 Category: Cytology Authors: Ling Dong Xufu Wei Le Yu Yixin Li Lixue Chen Source Type: research
Inhibition of SIRT7 promotes STAT1 activation and STAT1-dependent signaling in hepatocellular carcinoma
In conclusion, our data shed light on the intricate interplay between ubiquitination, STAT1, SIRT7, and Smurf1, elucidating their impact on STAT1-related signaling. These insights contribute to a more comprehensive understanding of the molecular mechanisms involved in STAT1 regulation and suggest potential avenues for the development of targeted therapies against cancer.PMID:38070755 | DOI:10.1016/j.cellsig.2023.111005 (Source: Cellular Signalling)
Source: Cellular Signalling - December 9, 2023 Category: Cytology Authors: Ling Dong Xufu Wei Le Yu Yixin Li Lixue Chen Source Type: research
Molecular mechanisms of pelvic organ prolapse influenced by FBLN5 via FOSL1/miR-222/MEIS1/COL3A1 axis
This study delves into the role of FBLN5 in pelvic organ prolapse (POP) and its molecular mechanisms, focusing on the FOSL1/miR-222/MEIS1/COL3A1 axis. Gene relationships linked to POP were confirmed using bioinformatics databases like GEO and StarBase. Primary human uterosacral ligament fibroblasts (hUSLF) were extracted and subjected to mechanical stretching. Cellular cytoskeletal changes were examined via phalloidin staining, intracellular ROS levels with a ROS kit, cell apoptosis through flow cytometry, and cell senescence using β-galactosidase staining. FBLN5's downstream targets were identified, and the interaction b...
Source: Cellular Signalling - December 6, 2023 Category: Cytology Authors: Rui Zhang Ya Li Jin Zhang Source Type: research
Molecular mechanisms of pelvic organ prolapse influenced by FBLN5 via FOSL1/miR-222/MEIS1/COL3A1 axis
This study delves into the role of FBLN5 in pelvic organ prolapse (POP) and its molecular mechanisms, focusing on the FOSL1/miR-222/MEIS1/COL3A1 axis. Gene relationships linked to POP were confirmed using bioinformatics databases like GEO and StarBase. Primary human uterosacral ligament fibroblasts (hUSLF) were extracted and subjected to mechanical stretching. Cellular cytoskeletal changes were examined via phalloidin staining, intracellular ROS levels with a ROS kit, cell apoptosis through flow cytometry, and cell senescence using β-galactosidase staining. FBLN5's downstream targets were identified, and the interaction b...
Source: Cellular Signalling - December 6, 2023 Category: Cytology Authors: Rui Zhang Ya Li Jin Zhang Source Type: research
Molecular mechanisms of pelvic organ prolapse influenced by FBLN5 via FOSL1/miR-222/MEIS1/COL3A1 axis
This study delves into the role of FBLN5 in pelvic organ prolapse (POP) and its molecular mechanisms, focusing on the FOSL1/miR-222/MEIS1/COL3A1 axis. Gene relationships linked to POP were confirmed using bioinformatics databases like GEO and StarBase. Primary human uterosacral ligament fibroblasts (hUSLF) were extracted and subjected to mechanical stretching. Cellular cytoskeletal changes were examined via phalloidin staining, intracellular ROS levels with a ROS kit, cell apoptosis through flow cytometry, and cell senescence using β-galactosidase staining. FBLN5's downstream targets were identified, and the interaction b...
Source: Cellular Signalling - December 6, 2023 Category: Cytology Authors: Rui Zhang Ya Li Jin Zhang Source Type: research
