Bioinformatics analysis and experimental validation of m6A and cuproptosis-related lncRNA NFE4 in clear cell renal cell carcinoma
ConclusionOverall, this study indicated that NFE4 and our constructed risk signature could predict outcomes and have potential clinical value. (Source: Hormones and Cancer)
Source: Hormones and Cancer - May 26, 2024 Category: Cancer & Oncology Source Type: research
A systematic review of antibody-drug conjugates and bispecific antibodies in head and neck squamous cell carcinoma and nasopharyngeal carcinoma: Charting the course of future therapies
Approximately 900,000 new diagnoses of neoplasms of the head and neck are made annually worldwide, leading to over 400,000 deaths. Head and neck squamous cell carcinoma (HNSCC) along with nasopharyngeal carcinoma (NPC), constitute roughly 90 % of these cases according the Global Cancer Observatory (GLOBOCAN) in 2020 [1]. Over the next two decades, a significant worldwide increase in the incidence of HNSCC, primarily those cases linked to the human papillomavirus (HPV), and NPC is predicted [2,3]. (Source: Cancer Treatment Reviews)
Source: Cancer Treatment Reviews - May 26, 2024 Category: Cancer & Oncology Authors: Pablo Jim énez-Labaig, Antonio Rullan, Alberto Hernando-Calvo, Sandra Llop, Shreerang Bhide, Ben O’Leary, Irene Braña, Kevin J. Harrington Tags: Systematic or Meta-analysis Studies Source Type: research
Viruses, Vol. 16, Pages 848: Two Concepts of Hepatitis B Core-Related Antigen Assay: A Highly Sensitive and Rapid Assay or an Effective Tool for Widespread Screening
anaka
Hepatitis B core-related antigen (HBcrAg) reflects the activity of intrahepatic covalently closed circular DNA. HBcrAg can be detected even in chronic hepatitis B patients in whom serum HBV DNA or hepatitis B surface antigen is undetectable. The HBcrAg measurement system was developed based on two concepts. One is a fully-automated and highly-sensitive HBcrAg assay (iTACT-HBcrAg) and the other is a point-of-care testing (POCT) that can be used in in resource-limited areas. iTACT-HBcrAg is an alternative to HBV DNA for monitoring HBV reactivation and predicting the development of hepatocellular carcinoma. This val...
Source: Viruses - May 26, 2024 Category: Virology Authors: Takako Inoue Shintaro Yagi Yasuhito Tanaka Tags: Review Source Type: research
Community-acquired pneumonia associated with immunosuppression due to follicular thyroid cancer: a case report
ConclusionThe case exemplifies the potential severity of community-acquired pneumonia in a patient with risk factors such as diabetes and immunosuppression. It highlights the complexity of treating multiple comorbidities and the importance of multidisciplinary management with close surveillance for timely interventions for complications. (Source: Journal of Medical Case Reports)
Source: Journal of Medical Case Reports - May 26, 2024 Category: General Medicine Source Type: research
Coptisine-mediated downregulation of E2F7 induces G2/M phase arrest in hepatocellular carcinoma cells through inhibition of E2F4/NFYA/NFYB transcription factors
In conclusion, our study demonstrated that COP downregulates E2F7 by affecting key transcription factors, thereby inducing cell cycle arrest and inhibits HCC cell growth. This provides further evidence of the efficacy of COP in the treatment of tumors.PMID:38795876 | DOI:10.1016/j.cbi.2024.111063 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - May 25, 2024 Category: Molecular Biology Authors: Hongmei Wang Zhengcai Ma Minmin Xu Mengyuan Xiong Xiantao Chen Yuan Zhou Wanyu Tang Xuegang Li Wanqun Chen Hang Ma Xiaoli Ye Source Type: research
Cationic liposomes as a drug-free system for efficient anticancer therapy by intracytoplasmic delivery of sodium bicarbonate
Colloids Surf B Biointerfaces. 2024 May 22;240:113984. doi: 10.1016/j.colsurfb.2024.113984. Online ahead of print.ABSTRACTDeveloping the delivery systems with high therapeutic efficacy and low side effects is of great interest and significance for anticancer therapy. Compared to the high cost in synthesizing new chemotherapeutic drugs, exploring the anticancer potentials of existing chemicals is more convenient and efficient. Sodium bicarbonate (BC), a simple inorganic salt, has shown its tumor inhibition capacity via regulating the acidity of tumor microenvironment. However, the effects of intracytoplasmic BC on tumor gro...
Source: Colloids and Surfaces - May 25, 2024 Category: Biotechnology Authors: Xiaotong Yu Mengying Xia Yuanhong Li Geyun Chen Chenhao Yu Qianming Chen Qiang Peng Source Type: research
Biomimetic platelet-like nanoparticles enhance targeted hepatocellular carcinoma therapy
Colloids Surf B Biointerfaces. 2024 May 16;240:113973. doi: 10.1016/j.colsurfb.2024.113973. Online ahead of print.ABSTRACTCurcumin (CUR) is a promising natural product for hepatocellular carcinoma (HCC) therapy. However, its clinical application has been limited by some issues such as rapid clearance and inadequate tumor accumulation. To address these drawbacks, we developed platelet membrane-coated CUR-loaded PLGA nanoparticles (PCPNPs). In this work, due to the bioinspired strategy, the PCPNPs exhibited immune evasion, prolonged circulation, and improved accumulation at tumor sites compared to the traditional CUR formula...
Source: Colloids and Surfaces - May 25, 2024 Category: Biotechnology Authors: Yuesong Wu Qingze Fan Jiahan Zhou Haiyang Hu Zuyue Liao Xiaoqin Tang Mengyao Xu Shuo Yang Jia Lai Shengli Wan Jianming Wu Source Type: research
Functional characterization of single nucleotide polymorphic variants of DNA repair enzyme NEIL1 in South Asian populations
In this study, the most common South Asian variants of NEIL1 were expressed, purified, and functionally characterized. All tested variants exhibited activities and substrate specificities similar to wild type (wt)-NEIL1 on high-molecular weight DNA containing an array of oxidatively-induced base lesions. On short oligodeoxynucleotides (17-mers) containing either a site-specific apurinic/apyrimidinic (AP) site, thymine glycol (ThyGly), or AFB1-FapyGua, P206L-NEIL1 was catalytically comparable to wt-NEIL1, while the activities of NEIL1 variants Q67K and T278I on these substrates were ≈2-fold reduced. Variant T103A had a gr...
Source: DNA Repair - May 25, 2024 Category: Genetics & Stem Cells Authors: Jamie T Zuckerman Asia Sage Jackson Irina G Minko Melis Kant Pawel Jaruga Michael P Stone Miral Dizdaroglu Amanda K McCullough R Stephen Lloyd Source Type: research
Insights into incipient oral squamous cell carcinoma: a comprehensive south-american study
CONCLUSIONS: To the best of our knowledge, this is the largest cohort of incipient oral squamous cell carcinoma patients, which raises awareness of clinicians' inspection acuteness by demonstrating the most frequent clinical aspects of this disease, potentially improving oral cancer secondary prevention strategies.PMID:38794942 | DOI:10.4317/medoral.26551 (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - May 25, 2024 Category: ENT & OMF Authors: C Saldivia-Siracusa A-L Ara újo L-P Arboleda T Abrantes M-B Pinto N Mendon ça K Cordero-Torres G Gilligan E Piemonte R Panico F De-Abreu- Álves M Villaroel-Dorrego Source Type: research
Salivary cortisol levels in patients with potentially malignant oral disorders and oral mucosal cancer: a case-control study
CONCLUSIONS: The increase in salivary cortisol levels in patients with PMD and SCC, is related to stress conditions, being able to generate alterations tending to immunosuppression of the cellular microenvironment.PMID:38794939 | DOI:10.4317/medoral.26606 (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - May 25, 2024 Category: ENT & OMF Authors: E L ópez-D'alessandro J Palomino L Escovich Source Type: research
Squamous cell carcinoma and basal cell carcinoma of the lips: 25 years of experience in a northeast Brazilian population
CONCLUSIONS: SCC was more frequent in male patients, while BCC showed more frequency in female patients. Both neoplasms mainly affect the lower lip. Understanding the epidemiological profile of these lesions in the lip, as well as their etiology and clinical features, is fundamental for appropriate clinical conduct and the creation and/or amplification of preventive measures.PMID:38794936 | DOI:10.4317/medoral.26454 (Source: Medicina Oral, Patologia Oral y Cirugia Bucal)
Source: Medicina Oral, Patologia Oral y Cirugia Bucal - May 25, 2024 Category: ENT & OMF Authors: W-R Silva M-M Bortoli S-R Leite C-C Barros M-D Brito L-T Montenegro R-J Vasconcellos D-P Iglesias A-P Sobral Source Type: research
Chitosan-modified manganese oxide-conjugated methotrexate nanoparticles delivering 5-aminolevulinic acid as a dual-modal T1-T2* MRI contrast agent in U87MG cell detection
CONCLUSION: This developed MnO2/CS@5-ALA-MTX nanoparticle system may exhibit great potential in the accurate diagnosis of folate receptor over-expressing cancers such as glioblastoma.PMID:38795276 | DOI:10.1007/s10334-024-01169-4 (Source: Magma)
Source: Magma - May 25, 2024 Category: Radiology Authors: Yasin Ayyami Marjan Ghorbani Masoumeh Dastgir Reza Malekzadeh Tohid Mortezazadeh Source Type: research
BIA-ALCL and BIA-SCC: Updates on Clinical Features and Genetic Mutations for Latest Recommendations
Medicina (Kaunas). 2024 May 10;60(5):793. doi: 10.3390/medicina60050793.ABSTRACTBreast Implant-Associated Anaplastic Large Cell Lymphoma (BIA-ALCL) and Breast Implant-Associated Squamous Cell Carcinoma (BIA-SCC) are emerging neoplastic complications related to breast implants. While BIA-ALCL is often linked to macrotextured implants, current evidence does not suggest an implant-type association for BIA-SCC. Chronic inflammation and genetics have been hypothesized as key pathogenetic players, although for both conditions, the exact mechanisms and specific risks related to breast implants are yet to be established. While the...
Source: Medicina (Kaunas) - May 25, 2024 Category: Universities & Medical Training Authors: Gennaro D'Orsi Martina Giacalone Alessio Calicchia Elettra Gagliano Lisa Vannucchi Gianluca Vanni Oreste Claudio Buonomo Valerio Cervelli Benedetto Longo Source Type: research
Clinicopathologic Analysis and Prognostic Factors for Survival in Patients with Operable Ampullary Carcinoma: A Multi-Institutional Retrospective Experience
Conclusions: Nodal status and a positive surgical margin were independent predictors of a poor mOS for patients with ampullary carcinomas. Additional studies are required to explore the role of adjuvant therapy in patients with ampullary carcinomas.PMID:38793001 | PMC:PMC11122928 | DOI:10.3390/medicina60050818 (Source: Medicina (Kaunas))
Source: Medicina (Kaunas) - May 25, 2024 Category: Universities & Medical Training Authors: Nebi Serkan Demirci Eyyup Cavdar Nuriye Yildirim Ozdemir Sinemis Yuksel Yakup Iriagac Gokmen Umut Erdem Hatice Odabas Ilhan Hacibekiroglu Mustafa Karaagac Mahmut Ucar Banu Ozturk Yakup Bozkaya Source Type: research
Long-term outcome of high-grade serous carcinoma established in risk-reducing salpingo-oophorectomy specimens in asymptomatic BRCA1/2 germline pathogenic variant carriers
CONCLUSION: Most asymptomatic BRCA1/2 GPV carriers with HGSC at RRSO were diagnosed at an early stage. Nevertheless, after a median follow-up of 13.5 years, nine of the 28 women with HGSC at RRSO developed a recurrence after a median of 6.9 years.PMID:38795508 | DOI:10.1016/j.ygyno.2024.05.024 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 25, 2024 Category: Cancer & Oncology Authors: Iris A S Stroot Joost Bart Harry Hollema Mathilde Jalving Marise M Wagner Refika Yigit Helena C van Doorn Joanne A de Hullu Katja N Gaarenstroom Marc van Beurden Luc R C W van Lonkhuijzen Brigitte F M Slangen Ronald P Zweemer Encarna B G ómez García Mar Source Type: research
