LNTgate: How LNT benefited from editorial actions
Chem Biol Interact. 2022 May 17:109979. doi: 10.1016/j.cbi.2022.109979. Online ahead of print.ABSTRACTThis paper illustrates how the acceptance of the linear non-threshold (LNT) dose response model was unethically advocated and advanced both by key scientists within the radiation genetics community, and by editorial practices in Science, a leading international scientific journal. Four key papers became the cornerstones in the acceptance of the LNT model. In the publication process of these papers, editorial decisions to circumvent peer review occurred in at least two cases. As well, the summarized data of one paper were n...
Source: Chemico-Biological Interactions - May 20, 2022 Category: Molecular Biology Authors: Edward J Calabrese James Giordano Source Type: research

New sight into interaction between endoplasmic reticulum stress and autophagy induced by vanadium in duck renal tubule epithelial cells
Chem Biol Interact. 2022 May 16:109981. doi: 10.1016/j.cbi.2022.109981. Online ahead of print.ABSTRACTVanadium (V) is a common environmental and industrial pollutant that can cause nephrotoxicity in animals in excess. The purpose of this research was to explore the interaction between endoplasmic reticulum (ER) stress and autophagy induced by V in the kidney of ducks. Duck renal tubule epithelial cells were exposed to different concentrations of sodium metavanadate (NaVO3) (0, 100 and 200 μM) and PERK inhibitor (GSK, 1 μM), or autophagy inhibitor (chloroquine, 50 μM) alone for 24 h (chloroquine for the last 4 h). The re...
Source: Chemico-Biological Interactions - May 19, 2022 Category: Molecular Biology Authors: Li Wang Yueying Pan Fan Yang Xiaowang Guo Junjun Peng Xiaoyu Wang Yukun Fang Jing Chen Xin Yi Huabin Cao Guoliang Hu Source Type: research

New sight into interaction between endoplasmic reticulum stress and autophagy induced by vanadium in duck renal tubule epithelial cells
Chem Biol Interact. 2022 May 16:109981. doi: 10.1016/j.cbi.2022.109981. Online ahead of print.ABSTRACTVanadium (V) is a common environmental and industrial pollutant that can cause nephrotoxicity in animals in excess. The purpose of this research was to explore the interaction between endoplasmic reticulum (ER) stress and autophagy induced by V in the kidney of ducks. Duck renal tubule epithelial cells were exposed to different concentrations of sodium metavanadate (NaVO3) (0, 100 and 200 μM) and PERK inhibitor (GSK, 1 μM), or autophagy inhibitor (chloroquine, 50 μM) alone for 24 h (chloroquine for the last 4 h). The re...
Source: Chemico-Biological Interactions - May 19, 2022 Category: Molecular Biology Authors: Li Wang Yueying Pan Fan Yang Xiaowang Guo Junjun Peng Xiaoyu Wang Yukun Fang Jing Chen Xin Yi Huabin Cao Guoliang Hu Source Type: research

Fenbendazole and its synthetic analog interfere with HeLa cells' proliferation and energy metabolism via inducing oxidative stress and modulating MEK3/6-p38-MAPK pathway
In conclusion, fenbendazole and analog 6 have multiple targets and strong anti-tumor effects on HeLa cells in vitro and in vivo. The optimized analog 6 could inhibit the viability of HeLa cells with lower toxicity than normal human cells, promising to be developed as an antitumor active compound.PMID:35569513 | DOI:10.1016/j.cbi.2022.109983 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - May 15, 2022 Category: Molecular Biology Authors: Yi Peng Jie Pan Fengting Ou Wenchao Wang Haihong Hu Lu Chen Su Zeng Kui Zeng Lushan Yu Source Type: research

Diffractaic acid, a novel TrxR1 inhibitor, induces cytotoxicity, apoptosis, and antimigration in human breast cancer cells
In conclusion, these data reveal that diffractaic acid may be considered an effective therapeutic agent for breast cancer treatment.PMID:35569514 | DOI:10.1016/j.cbi.2022.109984 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - May 15, 2022 Category: Molecular Biology Authors: Şeyda Nur Kalın Ahmet Altay Harun Budak Source Type: research

Fenbendazole and its synthetic analog interfere with HeLa cells' proliferation and energy metabolism via inducing oxidative stress and modulating MEK3/6-p38-MAPK pathway
In conclusion, fenbendazole and analog 6 have multiple targets and strong anti-tumor effects on HeLa cells in vitro and in vivo. The optimized analog 6 could inhibit the viability of HeLa cells with lower toxicity than normal human cells, promising to be developed as an antitumor active compound.PMID:35569513 | DOI:10.1016/j.cbi.2022.109983 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - May 15, 2022 Category: Molecular Biology Authors: Yi Peng Jie Pan Fengting Ou Wenchao Wang Haihong Hu Lu Chen Su Zeng Kui Zeng Lushan Yu Source Type: research

Diffractaic acid, a novel TrxR1 inhibitor, induces cytotoxicity, apoptosis, and antimigration in human breast cancer cells
In conclusion, these data reveal that diffractaic acid may be considered an effective therapeutic agent for breast cancer treatment.PMID:35569514 | DOI:10.1016/j.cbi.2022.109984 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - May 15, 2022 Category: Molecular Biology Authors: Şeyda Nur Kalın Ahmet Altay Harun Budak Source Type: research

Fenbendazole and its synthetic analog interfere with HeLa cells' proliferation and energy metabolism via inducing oxidative stress and modulating MEK3/6-p38-MAPK pathway
In conclusion, fenbendazole and analog 6 have multiple targets and strong anti-tumor effects on HeLa cells in vitro and in vivo. The optimized analog 6 could inhibit the viability of HeLa cells with lower toxicity than normal human cells, promising to be developed as an antitumor active compound.PMID:35569513 | DOI:10.1016/j.cbi.2022.109983 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - May 15, 2022 Category: Molecular Biology Authors: Yi Peng Jie Pan Fengting Ou Wenchao Wang Haihong Hu Lu Chen Su Zeng Kui Zeng Lushan Yu Source Type: research

Diffractaic acid, a novel TrxR1 inhibitor, induces cytotoxicity, apoptosis, and antimigration in human breast cancer cells
In conclusion, these data reveal that diffractaic acid may be considered an effective therapeutic agent for breast cancer treatment.PMID:35569514 | DOI:10.1016/j.cbi.2022.109984 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - May 15, 2022 Category: Molecular Biology Authors: Şeyda Nur Kalın Ahmet Altay Harun Budak Source Type: research

Fenbendazole and its synthetic analog interfere with HeLa cells' proliferation and energy metabolism via inducing oxidative stress and modulating MEK3/6-p38-MAPK pathway
In conclusion, fenbendazole and analog 6 have multiple targets and strong anti-tumor effects on HeLa cells in vitro and in vivo. The optimized analog 6 could inhibit the viability of HeLa cells with lower toxicity than normal human cells, promising to be developed as an antitumor active compound.PMID:35569513 | DOI:10.1016/j.cbi.2022.109983 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - May 15, 2022 Category: Molecular Biology Authors: Yi Peng Jie Pan Fengting Ou Wenchao Wang Haihong Hu Lu Chen Su Zeng Kui Zeng Lushan Yu Source Type: research

Diffractaic acid, a novel TrxR1 inhibitor, induces cytotoxicity, apoptosis, and antimigration in human breast cancer cells
In conclusion, these data reveal that diffractaic acid may be considered an effective therapeutic agent for breast cancer treatment.PMID:35569514 | DOI:10.1016/j.cbi.2022.109984 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - May 15, 2022 Category: Molecular Biology Authors: Şeyda Nur Kalın Ahmet Altay Harun Budak Source Type: research

Upregulation of the TFEB-mediated lysosome function relieves 4-Hydroxynonenal-Induced apoptosis
Chem Biol Interact. 2022 May 9:109963. doi: 10.1016/j.cbi.2022.109963. Online ahead of print.ABSTRACT4-Hydroxynonenal (4-HNE), the most toxic end-product of lipid peroxidation formed during oxidative stress, has been implicated in many diseases including neurodegenerative diseases, metabolic diseases, myocardial diseases, cancer and age-related diseases. 4-HNE can actively react with DNA, proteins and lipids, causing rapid cell death. The accumulation of 4-HNE leads to induction of autophagy, which clears damaged proteins and organelles. However, the underlying mechanism of 4-HNE-regulated autophagy is still not known. Tra...
Source: Chemico-Biological Interactions - May 13, 2022 Category: Molecular Biology Authors: Kaili Du Jiahui Shi Shixue Cheng Shuqi Hang Zongxian Ding Siyu Liu Dan Li Source Type: research

BCL2 inhibitor ABT-199 and BCL2L1 inhibitor WEHI-539 coordinately promote NOXA-mediated degradation of MCL1 in human leukemia cells
Chem Biol Interact. 2022 May 10:109978. doi: 10.1016/j.cbi.2022.109978. Online ahead of print.ABSTRACTHuman leukemia U937 cells that were continuously treated with hydroquinone (HQ) were transformed into U937/HQ cells with increased MCL1 and BCL2L1 expression. Compared with their parental cells, U937/HQ cells were less sensitive to ABT-263 (BCL2/BCL2L1 inhibitor)/ABT-199 (BCL2 inhibitor) cytotoxicity. The combination of WEHI-539 (BCL2L1 inhibitor) with either ABT-199 or ABT-263 showed synergistic cytotoxicity to U937 and U937/HQ cells. Therefore, we further investigated the cytotoxic mechanism induced by the combination of...
Source: Chemico-Biological Interactions - May 13, 2022 Category: Molecular Biology Authors: Jing-Ting Chiou Yuan-Chin Lee Liang-Jun Wang Long-Sen Chang Source Type: research

Upregulation of the TFEB-mediated lysosome function relieves 4-Hydroxynonenal-Induced apoptosis
Chem Biol Interact. 2022 May 9:109963. doi: 10.1016/j.cbi.2022.109963. Online ahead of print.ABSTRACT4-Hydroxynonenal (4-HNE), the most toxic end-product of lipid peroxidation formed during oxidative stress, has been implicated in many diseases including neurodegenerative diseases, metabolic diseases, myocardial diseases, cancer and age-related diseases. 4-HNE can actively react with DNA, proteins and lipids, causing rapid cell death. The accumulation of 4-HNE leads to induction of autophagy, which clears damaged proteins and organelles. However, the underlying mechanism of 4-HNE-regulated autophagy is still not known. Tra...
Source: Chemico-Biological Interactions - May 13, 2022 Category: Molecular Biology Authors: Kaili Du Jiahui Shi Shixue Cheng Shuqi Hang Zongxian Ding Siyu Liu Dan Li Source Type: research

BCL2 inhibitor ABT-199 and BCL2L1 inhibitor WEHI-539 coordinately promote NOXA-mediated degradation of MCL1 in human leukemia cells
Chem Biol Interact. 2022 May 10:109978. doi: 10.1016/j.cbi.2022.109978. Online ahead of print.ABSTRACTHuman leukemia U937 cells that were continuously treated with hydroquinone (HQ) were transformed into U937/HQ cells with increased MCL1 and BCL2L1 expression. Compared with their parental cells, U937/HQ cells were less sensitive to ABT-263 (BCL2/BCL2L1 inhibitor)/ABT-199 (BCL2 inhibitor) cytotoxicity. The combination of WEHI-539 (BCL2L1 inhibitor) with either ABT-199 or ABT-263 showed synergistic cytotoxicity to U937 and U937/HQ cells. Therefore, we further investigated the cytotoxic mechanism induced by the combination of...
Source: Chemico-Biological Interactions - May 13, 2022 Category: Molecular Biology Authors: Jing-Ting Chiou Yuan-Chin Lee Liang-Jun Wang Long-Sen Chang Source Type: research