Andrographolide ameliorates oxidative stress, inflammation and histological outcome in complete Freund's adjuvant-induced arthritis
ConclusionsAndrographolide acts as a protective agent for the treatment of complete freund's adjuvant induced rheumatoid arthritis by inhibiting lipid peroxidation and nitrite/nitrate levels in a dose-dependent manner, enhancing antioxidant enzyme activity, reducing levels of chemokines and inflammatory factors, preventing neutrophil accumulation and infiltration.Graphical abstract (Source: Chemico Biological Interactions)
Source: Chemico Biological Interactions - February 14, 2020 Category: Biochemistry Source Type: research

Uremic toxin indoxyl sulfate suppresses myocardial Cx43 assembly and expression via JNK activation
Publication date: Available online 8 February 2020Source: Chemico-Biological InteractionsAuthor(s): Chih-Ying Changchien, Meng-Ho Sung, Hsin-Han Chang, Wen-Chiuan Tsai, Yu-Sen Peng, Ying ChenAbstractHeart rhythm disturbances have been widely recognized as major triggers of cardiovascular (CV) mortality in chronic kidney disease (CKD) patients. Connexin 43 (Cx43)-composed gap junctions are essential in cardiomyocyte synchronization and may be involved in the pathological response to uremic toxins. Indoxyl sulfate (IS) is one of the most dominant uremic toxins that contribute to CKD-related cardiovascular diseases. In primar...
Source: Chemico Biological Interactions - February 10, 2020 Category: Biochemistry Source Type: research

Orientin reduces the inhibitory effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on adipogenic differentiation and insulin signaling pathway in murine 3T3-L1 adipocytes
In this study, orientin suppressed TCDD-induced loss of lipid accumulation. Orientin inhibited TCDD-driven decreases in the levels of peroxisome proliferator-activated receptor γ and adiponectin. Orientin also reduced TCDD-induced prostaglandin E2, and cytosolic phospholipase A2α levels, and increased TCDD-inhibited peroxisome proliferator-activated receptor gamma coactivator 1-alpha levels in 3T3-L1 adipocytes. TCDD reduced the levels of insulin receptor substrate 1 and glucose transporter 4, and decreased insulin-stimulated glucose uptake activity; however, orientin diminished these TCDD-induced effects. Thes...
Source: Chemico Biological Interactions - February 8, 2020 Category: Biochemistry Source Type: research

In vivo efficacy of the Reactive Skin Decontamination Lotion (RSDL®) kit against organophosphate and carbamate pesticides
In this study, we assessed the efficacy of the Reactive Skin Decontamination Lotion (RSDL®) Kit against parathion and aldicarb pesticide dermal exposure in a guinea pig model. The pesticides inhibit acetylcholinesterase (AChE) leading to signs and symptoms of hyperactivity of organs due to accumulation of acetylcholine. The RSDL Kit has been shown to physically remove and chemically degrade chemical warfare agents. Degradation occurs from a nucleophilic substitution reaction between an active ingredient in the RSDL lotion, potassium 2,3-butanedione monoximate (KBDO), with susceptible sites in these compounds. In the pr...
Source: Chemico Biological Interactions - February 8, 2020 Category: Biochemistry Source Type: research

Lignin-derived low-molecular-weight oxidized lignophenol stimulates AMP-activated protein kinase and suppresses renal inflammation and interstitial fibrosis in high fat diet-fed mice
In conclusion, LOLP suppressed macrophage infiltration and the increase in fibrotic area, and upregulated AMPK phosphorylation in the kidneys of HFD-fed mice; thus, it may ameliorate HFD-induced kidney injury. (Source: Chemico Biological Interactions)
Source: Chemico Biological Interactions - February 7, 2020 Category: Biochemistry Source Type: research

The genus Jatropha (Euphorbiaceae): A review on secondary chemical metabolites and biological aspects
Publication date: Available online 6 February 2020Source: Chemico-Biological InteractionsAuthor(s): Noelly Bastos Cavalcante, Alan Diego da Conceição Santos, Jackson Roberto Guedes da Silva AlmeidaAbstractThe genus Jatropha belongs to the Euphorbiaceae family and has about 175 species. Originally from tropical America, the Jatropha genus can be found all over the tropics and subtropics of Asia and Africa. Jatropha species are recognized to be important sources of secondary metabolites with a broad spectrum of biological functions. Extracts and isolated compounds from species of this genus have been known to h...
Source: Chemico Biological Interactions - February 7, 2020 Category: Biochemistry Source Type: research

Corrigendum to “Chronic exposure to arsenic and high fat diet induces sex-dependent pathogenic effects on the kidney” [Chem. Biol. Interact. 310 (2019) 108719]
Publication date: Available online 5 February 2020Source: Chemico-Biological InteractionsAuthor(s): Yixian Zhang, Jamie L. Young, Lu Cai, Yong Guang Tong, Lining Miao, Jonathan H. Freedman (Source: Chemico Biological Interactions)
Source: Chemico Biological Interactions - February 6, 2020 Category: Biochemistry Source Type: research

Carbon monoxide and its donors - Chemical and biological properties
Publication date: Available online 6 February 2020Source: Chemico-Biological InteractionsAuthor(s): Weronika Adach, Mateusz Błaszczyk, Beata OlasAbstractCarbon monoxide (CO) is an inorganic chemical compound that can bind with hemoglobin with highly toxic effects. In living organisms, it is produced endogenously during the degradation of heme by oxygenase, which occurs in three isoforms: HO-1, HO-2 and HO-3. CO can play an important role in the regulation of many physiological functions. Carbon Oxide Releasing Molecules (CORMs) are a novel group of chemical compounds capable of controlled CO release directly in tissues or...
Source: Chemico Biological Interactions - February 6, 2020 Category: Biochemistry Source Type: research

Monotherapy of RAAS blockers and mobilization of aldosterone: A mechanistic perspective study in kidney disease
Publication date: Available online 4 February 2020Source: Chemico-Biological InteractionsAuthor(s): Gaurav Gupta, Rajiv Dahiya, Yogendra Singh, Anurag Mishra, Aseem Verma, Sunil Kumar Gothwal, Alaa A.A. Aljabali, Harish Dureja, Parteek Prasher, Poonam Negi, Deepak N. Kapoor, Rohit Goyal, Murtaza M. Tambuwala, Dinesh K. Chellappan, Kamal DuaAbstractIn patients with acute kidney injury progressively converting into chronic kidney disease (CKD), proteinuria and high blood pressure predict progression to end-stage renal disease (ESRD). Although, Renin-angiotensin-aldosterone system (RAAS) regulates blood pressure and kidney di...
Source: Chemico Biological Interactions - February 5, 2020 Category: Biochemistry Source Type: research

Effect of ion doping in silica-based nanoparticles on the hemolytic and oxidative activity in contact with human erythrocytes
ConclusionIon doping with magnesium in the investigated calcium silicate system induces a protective effect in erythrocyte membrane in compare with pure silica nanoparticles. (Source: Chemico Biological Interactions)
Source: Chemico Biological Interactions - February 5, 2020 Category: Biochemistry Source Type: research

Taurine protects against cardiac dysfunction induced by pressure overload through SIRT1–p53 activation
ConclusionThe mechanism responsible for cardiac-protective effects of taurine in HF induced by pressure overload is associated with the activation of the SIRT1–p53 pathway. (Source: Chemico Biological Interactions)
Source: Chemico Biological Interactions - February 1, 2020 Category: Biochemistry Source Type: research

Phoenixin-20 suppresses lipopolysaccharide-induced inflammation in dental pulp cells
In this study, we found that GPR173 was fairly expressed in isolated human dental pulp cells, and its expression was reduced in response to pro-inflammatory lipopolysaccharide (LPS) treatment. The activation of GPR173 by its ligand Phoenixin-20 reduced LPS-induced cytotoxicity, as revealed by a reduction in the release of LDH. Additionally, Phoenixin-20 suppressed LPS-induced release of pro-inflammatory cytokines and inflammatory mediators, including IL-6, MCP-1, VCAM-1, and ICAM-1, as well as MMP-2 and MMP-9. Mechanistically, we showed the suppressive action of Phoenixin-20 on LPS-induced activation of TLR-4 and Myd88 as ...
Source: Chemico Biological Interactions - February 1, 2020 Category: Biochemistry Source Type: research

Rosuvastatin and retinoic acid may act as ‘pleiotropic agents’ against β-adrenergic agonist-induced acute myocardial injury through modulation of multiple signalling pathways
Publication date: Available online 30 January 2020Source: Chemico-Biological InteractionsAuthor(s): Faheem Sultan, Rajdeep Kaur, Arshad Hussain Mir, Ishfaq Maqbool, Milindmitra Lonare, Digvijay Singh, Satyavan Rampal, Javeed Ahmad DarAbstractCardiovascular disorders constitute the principal cause of deaths worldwide and will continue as the major disease-burden by the year 2060. A significant proportion of heart failures occur because of use and misuse of drugs and most of the investigational agents fail to achieve any clinical relevance. Here, we investigated rosuvastatin and retinoic acid for their “pharmacological...
Source: Chemico Biological Interactions - February 1, 2020 Category: Biochemistry Source Type: research

Modified expression of antioxidant genes in lobster cockroach, Nauphoeta cinerea exposed to methylmercury and monosodium glutamate
Publication date: Available online 31 January 2020Source: Chemico-Biological InteractionsAuthor(s): Blessing A. Afolabi, Olawande C. Olagoke, Diogo O. Souza, Michael Aschner, João B.T. Rocha, Ana Lúcia Anversa Segatto1. AbstractMethylmercury (MeHg) is a neurotoxicant that poses risk to human health and the environment, while glutamate homeostasis is necessary for the proper functioning of the brain. We have previously shown an increase in oxidative stress after cockroach exposure to diet containing monosodium glutamate (MSG), both separately and combined with a low dose of methylmercury. We herein seek to cor...
Source: Chemico Biological Interactions - February 1, 2020 Category: Biochemistry Source Type: research

Titanium dioxide nanoparticles promote oxidative stress, autophagy and reduce NLRP3 in primary rat astrocytes
Publication date: Available online 28 January 2020Source: Chemico-Biological InteractionsAuthor(s): José Antonio Pérez-Arizti, José Luis Ventura-Gallegos, Roberto Erasmo Galván Juárez, María del Pilar Ramos-Godinez, Zaira Colín-Val, Rebeca López-MarureAbstractTitanium dioxide nanoparticles (TiO2-NPs) are widely used in the food industry, cosmetics, personal care and paints among others. Through occupational exposure and daily consumption, and because of their small size, TiO2-NPs can enter the body through different routes such as oral, dermal and inhalation, and accu...
Source: Chemico Biological Interactions - January 29, 2020 Category: Biochemistry Source Type: research

Gastroprotective properties of Lupeol-derived ester: Pre-clinical evidences of Lupeol-stearate as a potent antiulcer agent
Publication date: Available online 29 January 2020Source: Chemico-Biological InteractionsAuthor(s): Lincon Bordignon Somensi, Philipe Costa, Thaise Boeing, Luísa Nathália Bolda Mariano, Bruna Longo, Cássia Gonçalves Magalhães, Priscila de Souza, Sérgio Faloni de Andrade, Luisa Mota da SilvaAbstractLupeol (1) was isolated from hexane branch extract of Maytenus salicifolia and the Lupeol stearate (2), Lupeol palmitate (3), Lupeol myristate (4), Lupeol laurate (5) and Lupeol caprylate (6) were obtained reacting 1 with an adequate carboxylic acid. Swiss mice were treated with vehicle, ...
Source: Chemico Biological Interactions - January 29, 2020 Category: Biochemistry Source Type: research

The protective effects of dulaglutide against advanced glycation end products (AGEs)-induced degradation of type Ⅱ collagen and aggrecan in human SW1353 chondrocytes
Publication date: Available online 29 January 2020Source: Chemico-Biological InteractionsAuthor(s): Hai Li, Jianhai Chen, Biao Li, Xiaoyan FangAbstractOsteoarthritis (OA) is one of the most prevalent degenerative joint diseases, and the risk of developing OA significantly increases with age as well as with concomitant diseases, such as diabetes. Advanced glycation end products (AGEs) accumulate in the body over time and are associated with increased expression of various molecules involved in the pathophysiology of OA. Prostaglandin E2 (PGE2), along with its precursor cyclooxygenase (COX)-2, plays an integral role in the p...
Source: Chemico Biological Interactions - January 29, 2020 Category: Biochemistry Source Type: research

Contribution of cholinergic system and Nrf2/HO-1 signaling to the anti-amnesic action of 7-fluoro-1,3-diphenylisoquinoline-1-amine in mice
This study investigated the contribution of oxidative stress, nuclear factor (erythroid-derived 2)-like 2 (Nrf2)/heme oxygenase (HO-1) signaling, and the cholinergic system to the anti-amnesic action of FDPI in mice. Adult male Swiss mice received FDPI for 5 days (5–25 mg/kg, i.g.); the animals received scopolamine (1 mg/kg, i.p) from day 3–5. The vehicle-control group was carried out. Afterward, mice performed object recognition tests (ORTs). Scopolamine induced amnesia and cholinergic dysfunction by increasing the acetylcholinesterase (AChE) activity and content, decreasing the muscarinic M1 receptor leve...
Source: Chemico Biological Interactions - January 29, 2020 Category: Biochemistry Source Type: research

S-adenosylhomocysteine (AdoHcy)-dependent methyltransferase inhibitor DZNep overcomes breast cancer tamoxifen resistance via induction of NSD2 degradation and suppression of NSD2-driven redox homeostasis
Publication date: Available online 28 January 2020Source: Chemico-Biological InteractionsAuthor(s): Qianqian Wang, Jianwei Zheng, June X. Zou, Jianzhen Xu, Fanghai Han, Songtao Xiang, Peiqing Liu, Hong-Wu Chen, Junjian WangAbstractEndocrine therapies (e.g. tamoxifen and aromatase inhibitors) targeting estrogen action are effective in decreasing mortality of breast cancer. However, their efficacy is limited by intrinsic and acquired resistance. Our previous study demonstrated that overexpression of a histone methyltransferase NSD2 drives tamoxifen resistance in breast cancer cells and that NSD2 is a potential biomarker of t...
Source: Chemico Biological Interactions - January 29, 2020 Category: Biochemistry Source Type: research

Functional role of ferroptosison cancers, activation and deactivation by various therapeutic candidates-an update
Publication date: 1 February 2020Source: Chemico-Biological Interactions, Volume 317Author(s): The Hong Phong Nguyen, B. Mahalakshmi, Bharath Kumar VelmuruganAbstractFerroptosis is recently identified form of regulated cell death which differs from previously identified cell death in a way that it is driven by iron-dependent lipid peroxide accumulation. Morphologically, cell volume shrinkage and increased mitochondrial membrane density are main features which characterize this form of cell death. Molecular mechanism of ferroptosis induction involved suppression of the phospholipid glutathione peroxidase 4 (GPX4) and furthe...
Source: Chemico Biological Interactions - January 29, 2020 Category: Biochemistry Source Type: research

Benzalkonium chloride and cetylpyridinium chloride induce apoptosis in human lung epithelial cells and alter surface activity of pulmonary surfactant monolayers
Publication date: Available online 24 January 2020Source: Chemico-Biological InteractionsAuthor(s): Sanae Kanno, Seishiro Hirano, Hideaki Kato, Mamiko Fukuta, Toshiji Mukai, Yasuhiro AokiAbstractQuaternary ammonium compounds (e.g., benzalkonium chloride (BAC) and cetylpyridinium chloride (CPC)) constitute a group of cationic surfactants are widely used for personal hygiene and medical care despite the potential pulmonary toxicity. To examine whether BAC and CPC aerosols deposited in the alveolar region alter pulmonary function, we studied the effects on pulmonary surfactant using two-step in vitro models; cytotoxicity usin...
Source: Chemico Biological Interactions - January 26, 2020 Category: Biochemistry Source Type: research

Knockdown of TRIM47 inhibits breast cancer tumorigenesis and progression through the inactivation of PI3K/Akt pathway
Publication date: Available online 22 January 2020Source: Chemico-Biological InteractionsAuthor(s): Yaqiu Wang, Can Liu, Zhihui Xie, Hong LuAbstractTripartite motif (TRIM) protein family is a group of proteins, which belongs to RING family of ubiquitin E3 ligases. TRIM proteins are involved in oncogenesis, while the roles in different cancers are controversial. However, the expression pattern and biological functions of TRIM47 in breast cancer remain unclear. In the present study, we aimed to investigate the function of TRIM47 in the progression and metastasis of breast cancer. TRIM47 was found to be significantly up-regul...
Source: Chemico Biological Interactions - January 23, 2020 Category: Biochemistry Source Type: research

Role of epigenetic in leukemia: From mechanism to therapy
Publication date: Available online 21 January 2020Source: Chemico-Biological InteractionsAuthor(s): Xiao-liang Liu, Huan-qiu Liu, Ji Li, Cui-ying Mao, Xin Zhao, Jin-ting HeAbstractEpigenetic variations can play remarkable roles in different normal and abnormal situations. Such variations have been shown to have a direct role in the pathogenesis of various diseases either through inhibition of tumor suppressor genes or increasing the expression of oncogenes. Enzymes involving in epigenetic machinery are the main actors in tuning the epigenetic-based controls on gene expressions. Aberrant expression of these enzymes can trig...
Source: Chemico Biological Interactions - January 23, 2020 Category: Biochemistry Source Type: research

Enolate-forming compounds provide protection from platinum neurotoxicity
Publication date: Available online 21 January 2020Source: Chemico-Biological InteractionsAuthor(s): Brian C. Geohagen, Daniel A. Weiser, David M. Loeb, Lars U. Nordstroem, Richard M. LoPachinAbstractCisplatin (CisPt) and other platinum (Pt)-based antineoplastic drugs (e.g., carboplatin, oxaliplatin) are highly effective and widely used in the treatment of solid tumors in both pediatric and adult patients. Although considered to be life-saving as a cancer treatment, Pt-based drugs frequently result in dose-limiting toxicities such as chemotherapy-induced peripheral neuropathies (CIPN). Specifically, irreversible damage to o...
Source: Chemico Biological Interactions - January 23, 2020 Category: Biochemistry Source Type: research

Immunological axis of berberine in managing inflammation underlying chronic respiratory inflammatory diseases
Publication date: Available online 20 January 2020Source: Chemico-Biological InteractionsAuthor(s): Xin Nee Tew, Natalie Jia Xin Lau, Dinesh Kumar Chellappan, Thiagarajan Madheswaran, Farrukh Zeeshan, Murtaza M. Tambuwala, Alaa AA. Aljabali, Sri Renukadevi Balusamy, Haribalan Perumalsamy, Gaurav Gupta, Brian G. Oliver, Alan Hsu, Peter Wark, Karosham Reddy, Ridhima Wadhwa, Philip Michael Hansbro, Kamal DuaAbstractInflammatory responses play a remarkable role in the mechanisms of acute and chronic respiratory diseases such as chronic obstructive pulmonary disease (COPD), asthma, pulmonary fibrosis and lung cancer. Currently,...
Source: Chemico Biological Interactions - January 20, 2020 Category: Biochemistry Source Type: research

Cantharidin suppresses gastric cancer cell migration/invasion by inhibiting the PI3K/Akt signaling pathway via CCAT1
In conclusion, our results provide new point into the critical role of CTD in suppressing PI3K/Akt signaling via down-regulation of CCAT1, resulting in suppression GC cell growth and migration/invasion. (Source: Chemico Biological Interactions)
Source: Chemico Biological Interactions - January 14, 2020 Category: Biochemistry Source Type: research

Fasudil enhanced differentiation of BMSCs in vivo and vitro, involvement of P38 signaling pathway
Publication date: Available online 11 January 2020Source: Chemico-Biological InteractionsAuthor(s): Meihui Chen, Dan Luo, Jiheng Zhan, Yu Hou, Shudong Chen, Xing Li, Dingkun LinAbstractBone mesenchymal stem cells (BMSCs) are a well-known donor graft source due to their potential for self-renewal and differentiation into multi-lineage cell types, including osteoblasts that are critical for fracture healing. Fasudil (FAS), a Rho kinase inhibitor, has been proven to induce the differentiation of bone marrow stem cells (BMSCs) into neuron-like cells. However, its role in the osteogenesis of BMSCs remain uncertain. Herein, we f...
Source: Chemico Biological Interactions - January 12, 2020 Category: Biochemistry Source Type: research

Benzoquinone derivatives with antioxidant activity inhibit activated hepatic stellate cells and attenuate liver fibrosis in TAA-induced mice
In this study, we investigated four benzoquinones derivatives, including 5-isopropyl-2-methyl-1,4-benzoquinone (TQ), 2-tert-butyl-1,4-benzoquinone (tBu-Q) 2,5-dimethyl-p-benzoquinone (Dime-Q) and p-benzoquinone (Ph-Q), as well as the evaluation of their antioxidant activity and anti-fibrotic effects on activated hepatic stellate cells and TAA-induced mice. Electrochemical analysis showed that all compounds possessed antioxidant property. The result was first confirmed by in vitro experiments, which revealed potential anti-fibrotic activity of all four compounds at the cellular level. Benzoquinone derivatives act as ROS-sca...
Source: Chemico Biological Interactions - January 12, 2020 Category: Biochemistry Source Type: research

Trigonelline protects hippocampal neurons from oxygen-glucose deprivation-induced injury through activating the PI3K/Akt pathway
Publication date: Available online 11 January 2020Source: Chemico-Biological InteractionsAuthor(s): Zhengguo Qiu, Kefeng Wang, Chao Jiang, Yuqiang Su, Xiaoying Fan, Jing Li, Sha Xue, Li YaoAbstractTrigonelline is a plant alkaloid that has generated interest for its neuroprotective roles in brain pathology. However, the protective effect of trigonelline on cerebral ischemia/reperfusion (I/R) injury and the potential mechanism have not been fully evaluated. Our results showed that trigonelline pretreatment ameliorated oxygen-glucose deprivation/reperfusion (OGD/R)-induced hippocampal neurons injury. The OGD/R-caused reactive...
Source: Chemico Biological Interactions - January 12, 2020 Category: Biochemistry Source Type: research

Apigenin attenuates pulmonary hypertension by inducing mitochondria-dependent apoptosis of PASMCs via inhibiting the hypoxia inducible factor 1α–KV1.5 channel pathway
In this study, we investigated the biological effects of apigenin on PH. PH was induced in male Sprague-Dawley rats by chronic hypoxia exposure. Administration of apigenin prevented the development of PH, hypoxia-induced right ventricular hypertrophy and pulmonary arterial remodelling and prevented the progression of established PH in this model. Moreover, treatment with apigenin induced mitochondria-dependent apoptosis. To explore the underlying mechanisms, the mitochondrial membrane potential (Δψm) and the mitochondria-dependent apoptosis factors cytochrome C, BAX, Bcl-2, cleaved caspase 3, and cleaved caspase ...
Source: Chemico Biological Interactions - January 11, 2020 Category: Biochemistry Source Type: research

Cytoprotective effects of berry anthocyanins against induced oxidative stress and inflammation in primary human diabetic aortic endothelial cells
This study determined to explore the protective effects of berry-derived anthocyanins (AC) with potent antioxidant and anti-inflammatory activities in human diabetic endothelial cells upon oxidative and inflammatory stressors. Cultured healthy human aortic endothelial cells (HAEC) and diabetic human aortic endothelial cells (D-HAEC) exposed to oxidative stress by hydrogen peroxide (H2O2, 75 μM) and lipopolysaccharide (LPS, 1 μg/mL) as an inflammatory inducer before treatment with AC (50 μl/ml). The results from cytotoxicity assays showed that AC had no significant effects in cell viability (P-value 
Source: Chemico Biological Interactions - January 11, 2020 Category: Biochemistry Source Type: research

Effect of m-trifluoromethyl-diphenyl diselenide on acute and subchronic animal models of inflammatory pain: Behavioral, biochemical and molecular insights
Publication date: Available online 9 January 2020Source: Chemico-Biological InteractionsAuthor(s): Paulo Cesar Oliveira Araujo, Marcel Henrique Marcondes Sari, Natália Silva Jardim, Juliano Ten Kathen Jung, César Augusto BrüningAbstractm-Trifluoromethyl-diphenyl diselenide [(m-CF3-PhSe)2] is an organoselenium molecule that displays multiple pharmacological actions, including the antinociceptive effect. The current study investigated the (m-CF3-PhSe)2 restorative properties in models of acute and chronic inflammatory pain induced by complete Freund's adjuvant (CFA). Male adult Swiss mice received an intra...
Source: Chemico Biological Interactions - January 11, 2020 Category: Biochemistry Source Type: research

Nicotine-induced autophagy via AMPK/mTOR pathway exerts protective effect in colitis mouse model
Publication date: Available online 10 January 2020Source: Chemico-Biological InteractionsAuthor(s): Qian Gao, Pinduan Bi, Ding Luo, Ying Guan, Wanli Zeng, Haiying Xiang, Qili Mi, Guangyu Yang, Xuemei Li, Bin YangAbstractEpidemiological studies have shown that cigarette smoking is beneficial in ulcerative colitis and that nicotine may be responsible for this effect. However, the mechanism remains unclear. In a previous study, nicotine was found to induce autophagy in intestinal cells. Here, we evaluated the effect of nicotine-induced autophagy in a dextran sodium sulfate (DSS)-induced colitis mouse model. C57BL/6 adult male...
Source: Chemico Biological Interactions - January 11, 2020 Category: Biochemistry Source Type: research

Eugenol restricts Cancer Stem Cell population by degradation of β-catenin via N-terminal Ser37 phosphorylation-an in vivo and in vitro experimental evaluation
In this study, the effect of eugenol on CSC (Cancer Stem Cell) markers and its main regulator β-catenin both in vivo Ehrlich Ascites Carcinoma (EAC) cell line and in vitro MCF-7 cell line was investigated with that of the untreated group. The therapeutic doses were found to significantly induce apoptosis leaving normal mice and cells unaffected. The in-depth analysis revealed the downregulation of β-catenin thereby facilitating its degradation by N-terminal phosphorylation of Ser37 residue. Significant downregulation of various CSC markers was also observed in vivo after eugenol treatment those are regulated by...
Source: Chemico Biological Interactions - January 9, 2020 Category: Biochemistry Source Type: research

Comparison of long-term versus short-term effects of okadaic acid on the apoptotic status of human HepaRG cells
In conclusion, our results show a clear concentration- and time-dependency of OA-mediated apoptotic effects in HepaRG cells and contribute to the elucidation of molecular effects of OA. (Source: Chemico Biological Interactions)
Source: Chemico Biological Interactions - January 8, 2020 Category: Biochemistry Source Type: research

Ganoderic acid DM induces autophagic apoptosis in non-small cell lung cancer cells by inhibiting the PI3K/Akt/mTOR activity
In conclusion, our study indicated that GA-DM can induce autophagic apoptosis in NSCLC by inhibiting Akt/mTOR activity. (209 words). (Source: Chemico Biological Interactions)
Source: Chemico Biological Interactions - December 24, 2019 Category: Biochemistry Source Type: research

GSPE alleviates renal fibrosis by inhibiting the activation of C3/ HMGB1/ TGF-β1 pathway
In this study, we aimed to identify the effect of GSPE on C3 in the chronic kidney fibrosis and evaluate the possible mechanism. We observed that administration of GSPE relieves inflammation and chronic renal fibrosis in mouse models of UUO. GSPE inhibited C3 secreted by macrophages to relieve renal interstitial inflammation. In vitro, we found that C3 stimulated HMGB1 translocation form nucleus to cytoplasm and promote the expression of pro-inflammatory cytokines including TGF-β1 in primary renal tubular epithelial cells (PTEC), which could be inhibited by GSPE. Meanwhile, GSPE could also decreased HMGB1-induced EMT ...
Source: Chemico Biological Interactions - December 24, 2019 Category: Biochemistry Source Type: research

PDGFBB-modified stem cells from apical papilla and thermosensitive hydrogel scaffolds induced bone regeneration
Publication date: Available online 23 December 2019Source: Chemico-Biological InteractionsAuthor(s): Jiajia Deng, Jie Pan, Xinxin Han, Liming Yu, Jing Chen, Weihua Zhang, Luying Zhu, Wei Huang, Shangfeng Liu, Zhengwei You, Yuehua LiuAbstractBone defects caused by cancer surgery or trauma have a strong negative impact on human health. Treatment with cell and material-based complexes provides an alternative strategy for the regeneration of damaged bone tissue. The good physical properties and suitable biodegradability of a thermosensitive hydrogel has been shown to act as a valuable scaffold. Platelet derived growth factor B...
Source: Chemico Biological Interactions - December 24, 2019 Category: Biochemistry Source Type: research

Anti-cancer effects of Polyphyllin I: An update in 5 years
Publication date: Available online 20 December 2019Source: Chemico-Biological InteractionsAuthor(s): Ye Tian, Guan-Yu Gong, Liang-Liang Ma, Zhuo-Qun Wang, Dan Song, Mei-Yun FangAbstractChong-lou, the rhizome of Paris polyphylla, has been used in herbal regimes to treat parotitis, mastitis and certain malignant tumors for thousands of years in traditional medicine. Polyphyllin I (PPI) is the main bioactive component in Paris polyphylla. Recent studies of PPI in various types of cancers have shown that PPI may exert a broad spectrum of anti-tumor effects, including inducing cell cycle arrest, inducing cell apoptosis, inducin...
Source: Chemico Biological Interactions - December 21, 2019 Category: Biochemistry Source Type: research

Effects of inflammation on irinotecan pharmacokinetics and development of a best-fit PK model
In this study, we investigated the effects of inflammation on the pharmacokinetics (PK) of irinotecan (CPT-11) and its active metabolite, SN-38. Mice were i.p.-injected with either saline or lipopolysaccharide (LPS) to induce inflammation. After 16 h, irinotecan was administered orally. Blood was collected from the tail vein of mice from 0 to 24 h after dosing. Concentrations of irinotecan, SN-38 and SN-38G were analyzed using LC-MS/MS. The AUC, Cmax, and tmax were derived using WinNonlin® 5.2. A PK model was developed using Phoenix NLME® to describe the PK of irinotecan and SN-38 during inflammation. Results i...
Source: Chemico Biological Interactions - December 21, 2019 Category: Biochemistry Source Type: research

Osthole induces cell cycle arrest and apoptosis in head and neck squamous cell carcinoma by suppressing the PI3K/AKT signaling pathway
ConclusionsIn the current study, our in vitro and in vivo assay showed the suppressive effect of Osthole on HNSCC cells through induce cell cycle arrest (G2/M phase) and apoptosis. Moreover, the action mechanisms of Osthole on proliferation related signaling pathways was disclosed. Our present study suggests that osthole might be used as an effective therapeutic agent for patients with HNSCC. (Source: Chemico Biological Interactions)
Source: Chemico Biological Interactions - December 21, 2019 Category: Biochemistry Source Type: research

Agonism of GPR120 prevents ox-LDL-induced attachment of monocytes to endothelial cells
Publication date: Available online 21 December 2019Source: Chemico-Biological InteractionsAuthor(s): Tiechao Jiang, Dongli Jiang, Dong You, Lirong Zhang, Long Liu, Qini ZhaoAbstractOxidized low-density lipoprotein (ox-LDL)-induced endothelial inflammation plays an important role in the development of cardiovascular diseases. G protein-coupled receptors (GPCR) are gaining traction as potential treatment targets due to their roles in mediating a wide range of physiological processes. GPR120 is a recently identified omega-3 fatty acid receptor. We hypothesized that agonism of GPR120 might attenuate ox-LDL-induced endothelial ...
Source: Chemico Biological Interactions - December 21, 2019 Category: Biochemistry Source Type: research

Iron-based nanoparticles and their potential toxicity: Focus on oxidative stress and apoptosis
Publication date: Available online 21 December 2019Source: Chemico-Biological InteractionsAuthor(s): Jovana Paunovic, Danijela Vucevic, Tatjana Radosavljevic, Stefan Mandić-Rajčević, Igor PanticAbstractRecently, there have been several studies indicating that iron-based nanomaterials may exhibit certain toxic properties. Compared to conventional iron and iron oxides, iron nanoparticles (FeNPs) have some unique physical and chemical traits which impact their absorption, biodistribution and elimination. Facilitated passage through biological barriers enables FeNPs to reach various tissues and cells, and interact with a va...
Source: Chemico Biological Interactions - December 21, 2019 Category: Biochemistry Source Type: research

Functional role of ferroptosis on cancers, activation and deactivation by various therapeutic candidates-an update
Publication date: Available online 19 December 2019Source: Chemico-Biological InteractionsAuthor(s): B. Mahalakshmi, Hai-Liang Huang, Shin-Da Lee, Bharath Kumar VelmuruganAbstractFerroptosis is recently identified form of regulated cell death which differs from previously identified cell death in a way that it is driven by iron-dependent lipid peroxide accumulation. Morphologically, cell volume shrinkage and increased mitochondrial membrane density are main features which characterize this form of cell death. Molecular mechanism of ferroptosis induction involved suppression of the phospholipid glutathione peroxidase 4 (GPX...
Source: Chemico Biological Interactions - December 20, 2019 Category: Biochemistry Source Type: research

Sodium acetate protects against nicotine-induced excess hepatic lipid in male rats by suppressing xanthine oxidase activity
Publication date: Available online 16 December 2019Source: Chemico-Biological InteractionsAuthor(s): E.O. Dangana, T.E. Omolekulo, E.D. Areola, K.S. Olaniyi, A.O. Soladoye, L.A. OlatunjiAbstractFatty liver is the hepatic consequence of chronic insulin resistance (IR) and related syndromes. It is mostly accompanied by inflammatory and oxidative molecules. Increased activity of xanthine oxidase (XO) exerts both inflammatory and oxidative effects and has been implicated in metabolic derangements including non-alcoholic fatty liver disease. Short chain fatty acids (SCFAs) elicit beneficial metabolic alterations in IR and relat...
Source: Chemico Biological Interactions - December 18, 2019 Category: Biochemistry Source Type: research

HIPK2 overexpression relieves hypoxia/reoxygenation-induced apoptosis and oxidative damage of cardiomyocytes through enhancement of the Nrf2/ARE signaling pathway
Publication date: Available online 16 December 2019Source: Chemico-Biological InteractionsAuthor(s): Xiaoyan Dang, Rui Zhang, Zhuo Peng, Yong Qin, Jiangli Sun, Zequn Niu, Honghong PeiAbstractHomeodomain interacting protein kinase-2 (HIPK2) has emerged as a crucial stress-responsive kinase that plays a critical role in regulating cell survival and apoptosis. However, whether HIPK2 participates in regulating cardiomyocyte survival during myocardial ischemia/reperfusion injury remains unclear. Here, we investigated the regulatory effect of HIPK2 on hypoxia/reoxygenation (H/R)-induced cardiomyocyte injury and its potential und...
Source: Chemico Biological Interactions - December 18, 2019 Category: Biochemistry Source Type: research

Isoniazid promotes the anti-inflammatory response in zebrafish associated with regulation of the PPARγ/NF-κB/AP-1 pathway
ConclusionIn this study, different zebrafish inflammation models were used to confirm that INH has anti-inflammatory activity. The associated mechanism may occur through the inhibition of ROS release, activation of PPARγ expression, inhibition of the transcriptional regulatory activity of NF-κB and AP-1, and reduction of INH inflammatory factor expression to relieve inflammation. The results of this study provide references for the clinical application of INH.Graphical abstract (Source: Chemico Biological Interactions)
Source: Chemico Biological Interactions - December 18, 2019 Category: Biochemistry Source Type: research

The influence of carboxylesterase 1 polymorphism and cannabidiol on the hepatic metabolism of heroin
In this study, we sought to determine the contribution of the major hepatic hydrolase carboxylesterase 1 (CES1) to heroin metabolism in the liver as well as the potential influence of one of its known genetic variants, G143E (rs71647871). Furthermore, given the potential therapeutic application of cannabidiol (CBD) for heroin addiction and the frequent co-abuse of cannabis and heroin, we also assessed the effects of CBD on heroin metabolism. In vitro systems containing human liver, wild-type CES1, and G143E CES1 S9 fractions were utilized in the assessment. The contribution of CES1 to the hydrolysis of heroin to 6-MAM was ...
Source: Chemico Biological Interactions - December 18, 2019 Category: Biochemistry Source Type: research

Acetylation of cedrelone increases its cytotoxic activity and reverts the malignant phenotype of breast cancer cells in 3D culture
Publication date: Available online 16 December 2019Source: Chemico-Biological InteractionsAuthor(s): Amanda Blanque Becceneri, Angelina Maria Fuzer, Cecília Patrícia Popolin, Cristiane de Melo Cazal, Vanessa de Cássia Domingues, João Batista Fernandes, Paulo Cezar Vieira, Marcia Regina CominettiAbstractCedrelone is a limonoid isolated from the plant Trichilia catigua (Meliaceae). Previous studies have demonstrated that cedrelone (1) has several damaging effects on triple negative breast tumor (TNBC) cell line MDA-MB-231. In this work we investigated two new derivatives of cedrelone, the acetate ...
Source: Chemico Biological Interactions - December 16, 2019 Category: Biochemistry Source Type: research

Modification of stem cell states by alcohol and acetaldehyde
Publication date: Available online 14 December 2019Source: Chemico-Biological InteractionsAuthor(s): Ryan N. Serio, Lorraine J. GudasAbstractEthanol (EtOH) is a recreationally ingested compound that is both teratogenic and carcinogenic in humans. Because of its abundant consumption worldwide and the vital role of stem cells in the formation of birth defects and cancers, delineating the effects of EtOH on stem cell function is currently an active and urgent pursuit of scientific investigation to explicate some of the mechanisms contributing to EtOH toxicity. Stem cells represent a primordial, undifferentiated phase of devel...
Source: Chemico Biological Interactions - December 15, 2019 Category: Biochemistry Source Type: research