Amino acid derivative of probenecid potentiates apoptosis-inducing effects of vinblastine by increasing oxidative stress in a cancer cell-specific manner
Chem Biol Interact. 2023 Dec 13:110833. doi: 10.1016/j.cbi.2023.110833. Online ahead of print.ABSTRACTMany chemotherapeutic drugs suffer from multidrug resistance (MDR). Efflux transporters, namely ATP-binding cassettes (ABCs), that pump the drugs out of the cancer cells comprise one major reason behind MDR. Therefore, ABC inhibitors have been under development for ages, but unfortunately, without clinical success. In the present study, an L-type amino acid transporter 1 (LAT1)-utilizing derivative of probenecid (PRB) was developed as a cancer cell-targeted efflux inhibitor for P-glycoprotein (P-gp), breast cancer resistan...
Source: Chemico-Biological Interactions - December 15, 2023 Category: Molecular Biology Authors: Johanna Huttunen Janne Tampio Juulia J ärvinen Ahmed B Montaser Magdalena Markowicz-Piasecka Kristiina M Huttunen Source Type: research
Exogenous 1,25(OH) < sub > 2 < /sub > D < sub > 3 < /sub > /VD < sub > 3 < /sub > counteracts RSL3-Induced ferroptosis by enhancing antioxidant capacity and regulating iron ion transport: Using zebrafish as a model
This study demonstrated the resistance of VD3 to RSL3-induced ferroptosis at different developmental stages in zebrafish.PMID:38081571 | DOI:10.1016/j.cbi.2023.110828 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - December 11, 2023 Category: Molecular Biology Authors: Ke Cheng Gang Yang Min Huang Yanqing Huang Chunfang Wang Source Type: research
Niacin treatment prevents bone loss in iron overload osteoporotic rats via activation of SIRT1 signaling pathway
Chem Biol Interact. 2023 Dec 9:110827. doi: 10.1016/j.cbi.2023.110827. Online ahead of print.ABSTRACTRecently, more and more studies have revealed that iron overload can lead to osteoporosis by inducing oxidative stress. Niacin (NAN), also known as nicotinate or vitamin B3, has been confirmed to possess potent antioxidative effects. In addition, very little is currently known about the protective effects of NAN on iron overload in osteoporotic bone tissue. Therefore, we aimed to evaluate the protective effect of niacin on iron overload-induced bone injury and to investigate the effect and underlying mechanisms of the niaci...
Source: Chemico-Biological Interactions - December 11, 2023 Category: Molecular Biology Authors: Zhou-Shan Tao Mao-Sheng Zhou Xing-Jing Wu Source Type: research
Exogenous 1,25(OH) < sub > 2 < /sub > D < sub > 3 < /sub > /VD < sub > 3 < /sub > counteracts RSL3-Induced ferroptosis by enhancing antioxidant capacity and regulating iron ion transport: Using zebrafish as a model
This study demonstrated the resistance of VD3 to RSL3-induced ferroptosis at different developmental stages in zebrafish.PMID:38081571 | DOI:10.1016/j.cbi.2023.110828 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - December 11, 2023 Category: Molecular Biology Authors: Ke Cheng Gang Yang Min Huang Yanqing Huang Chunfang Wang Source Type: research
Niacin treatment prevents bone loss in iron overload osteoporotic rats via activation of SIRT1 signaling pathway
Chem Biol Interact. 2023 Dec 9:110827. doi: 10.1016/j.cbi.2023.110827. Online ahead of print.ABSTRACTRecently, more and more studies have revealed that iron overload can lead to osteoporosis by inducing oxidative stress. Niacin (NAN), also known as nicotinate or vitamin B3, has been confirmed to possess potent antioxidative effects. In addition, very little is currently known about the protective effects of NAN on iron overload in osteoporotic bone tissue. Therefore, we aimed to evaluate the protective effect of niacin on iron overload-induced bone injury and to investigate the effect and underlying mechanisms of the niaci...
Source: Chemico-Biological Interactions - December 11, 2023 Category: Molecular Biology Authors: Zhou-Shan Tao Mao-Sheng Zhou Xing-Jing Wu Source Type: research
Exogenous 1,25(OH) < sub > 2 < /sub > D < sub > 3 < /sub > /VD < sub > 3 < /sub > counteracts RSL3-Induced ferroptosis by enhancing antioxidant capacity and regulating iron ion transport: Using zebrafish as a model
This study demonstrated the resistance of VD3 to RSL3-induced ferroptosis at different developmental stages in zebrafish.PMID:38081571 | DOI:10.1016/j.cbi.2023.110828 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - December 11, 2023 Category: Molecular Biology Authors: Ke Cheng Gang Yang Min Huang Yanqing Huang Chunfang Wang Source Type: research
Niacin treatment prevents bone loss in iron overload osteoporotic rats via activation of SIRT1 signaling pathway
Chem Biol Interact. 2023 Dec 9:110827. doi: 10.1016/j.cbi.2023.110827. Online ahead of print.ABSTRACTRecently, more and more studies have revealed that iron overload can lead to osteoporosis by inducing oxidative stress. Niacin (NAN), also known as nicotinate or vitamin B3, has been confirmed to possess potent antioxidative effects. In addition, very little is currently known about the protective effects of NAN on iron overload in osteoporotic bone tissue. Therefore, we aimed to evaluate the protective effect of niacin on iron overload-induced bone injury and to investigate the effect and underlying mechanisms of the niaci...
Source: Chemico-Biological Interactions - December 11, 2023 Category: Molecular Biology Authors: Zhou-Shan Tao Mao-Sheng Zhou Xing-Jing Wu Source Type: research
Exogenous 1,25(OH) < sub > 2 < /sub > D < sub > 3 < /sub > /VD < sub > 3 < /sub > counteracts RSL3-Induced ferroptosis by enhancing antioxidant capacity and regulating iron ion transport: Using zebrafish as a model
This study demonstrated the resistance of VD3 to RSL3-induced ferroptosis at different developmental stages in zebrafish.PMID:38081571 | DOI:10.1016/j.cbi.2023.110828 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - December 11, 2023 Category: Molecular Biology Authors: Ke Cheng Gang Yang Min Huang Yanqing Huang Chunfang Wang Source Type: research
Niacin treatment prevents bone loss in iron overload osteoporotic rats via activation of SIRT1 signaling pathway
Chem Biol Interact. 2023 Dec 9:110827. doi: 10.1016/j.cbi.2023.110827. Online ahead of print.ABSTRACTRecently, more and more studies have revealed that iron overload can lead to osteoporosis by inducing oxidative stress. Niacin (NAN), also known as nicotinate or vitamin B3, has been confirmed to possess potent antioxidative effects. In addition, very little is currently known about the protective effects of NAN on iron overload in osteoporotic bone tissue. Therefore, we aimed to evaluate the protective effect of niacin on iron overload-induced bone injury and to investigate the effect and underlying mechanisms of the niaci...
Source: Chemico-Biological Interactions - December 11, 2023 Category: Molecular Biology Authors: Zhou-Shan Tao Mao-Sheng Zhou Xing-Jing Wu Source Type: research
Bisdemethoxycurcumin, a curcumin derivative, ameliorates adjuvant-induced arthritis by suppressing inflammatory reactions and macrophage migration
Chem Biol Interact. 2023 Dec 5;387:110822. doi: 10.1016/j.cbi.2023.110822. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a highly prevalent and chronic inflammatory synovial joint disease manifested by hyperplasia and continuous inflammation. Curcumin (Cur) has been studied for alleviating RA. However, poor stability and oral bioavailability restrict its therapeutic value. Bisdemethoxycurcumin (BDMC), a curcumin (Cur) derivative, exerts better stability and oral bioavailability than Cur. However, the efficacy of BDMC on RA has not been fully clarified. The aim of the study was to investigate the therapeutic eď...
Source: Chemico-Biological Interactions - December 6, 2023 Category: Molecular Biology Authors: Xuehui Sun Ying Liang Yu Wang Chuanfen Sun Xianbin Wang Source Type: research
Aureusidin ameliorates 6-OHDA-induced neurotoxicity via activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway in SH-SY5Y cells and Caenorhabditis elegans
In conclusion, Aureusidin showed a neuroprotective effect in the 6-OHDA-induced PD model via activating Nrf2/HO-1 signaling pathway and prevented mitochondria-dependent apoptosis pathway, and these findings suggested that Aureusidin may be an effective drug for the treatment of PD.PMID:38056806 | DOI:10.1016/j.cbi.2023.110824 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - December 6, 2023 Category: Molecular Biology Authors: Kun Hu Susu Zhu Fanyu Wu Yongzhen Zhang Minyue Li Ling Yuan Wenjing Huang Yichi Zhang Jie Wang Jie Ren Hao Yang Source Type: research
Inhibition of cisplatin-induced Acsl4-mediated ferroptosis alleviated ovarian injury
In this study, we demonstrated that cisplatin treatment caused the accumulation of iron ions which induced ferroptosis in ovarian tissue. And our results show that ferrostatin-1 was able to suppress the ovarian injury and granulosa cell death caused by cisplatin (Cis) in vivo and in vitro. At the same time, we observed significant changes in the expression levels of Acyl-CoA synthetase long-chain family member 4 (Acsl4) and glutathione peroxidase 4 (GPX4). Similarly, Rosiglitazone, an inhibitor of Acsl4, administration alleviated the ovary damage of the mice undergoing chemotherapy. Further mechanistic investigation showed...
Source: Chemico-Biological Interactions - December 6, 2023 Category: Molecular Biology Authors: Siyuan Wang Xuqing Li Jun Li Aiping Wang Fangfang Li Huiqing Hu Tengfei Long Xueting Pei Hongyan Li Fei Zhong Fengyu Zhu Source Type: research
Bisdemethoxycurcumin, a curcumin derivative, ameliorates adjuvant-induced arthritis by suppressing inflammatory reactions and macrophage migration
Chem Biol Interact. 2023 Dec 5;387:110822. doi: 10.1016/j.cbi.2023.110822. Online ahead of print.ABSTRACTRheumatoid arthritis (RA) is a highly prevalent and chronic inflammatory synovial joint disease manifested by hyperplasia and continuous inflammation. Curcumin (Cur) has been studied for alleviating RA. However, poor stability and oral bioavailability restrict its therapeutic value. Bisdemethoxycurcumin (BDMC), a curcumin (Cur) derivative, exerts better stability and oral bioavailability than Cur. However, the efficacy of BDMC on RA has not been fully clarified. The aim of the study was to investigate the therapeutic eď...
Source: Chemico-Biological Interactions - December 6, 2023 Category: Molecular Biology Authors: Xuehui Sun Ying Liang Yu Wang Chuanfen Sun Xianbin Wang Source Type: research
Aureusidin ameliorates 6-OHDA-induced neurotoxicity via activating Nrf2/HO-1 signaling pathway and preventing mitochondria-dependent apoptosis pathway in SH-SY5Y cells and Caenorhabditis elegans
In conclusion, Aureusidin showed a neuroprotective effect in the 6-OHDA-induced PD model via activating Nrf2/HO-1 signaling pathway and prevented mitochondria-dependent apoptosis pathway, and these findings suggested that Aureusidin may be an effective drug for the treatment of PD.PMID:38056806 | DOI:10.1016/j.cbi.2023.110824 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - December 6, 2023 Category: Molecular Biology Authors: Kun Hu Susu Zhu Fanyu Wu Yongzhen Zhang Minyue Li Ling Yuan Wenjing Huang Yichi Zhang Jie Wang Jie Ren Hao Yang Source Type: research
Inhibition of cisplatin-induced Acsl4-mediated ferroptosis alleviated ovarian injury
In this study, we demonstrated that cisplatin treatment caused the accumulation of iron ions which induced ferroptosis in ovarian tissue. And our results show that ferrostatin-1 was able to suppress the ovarian injury and granulosa cell death caused by cisplatin (Cis) in vivo and in vitro. At the same time, we observed significant changes in the expression levels of Acyl-CoA synthetase long-chain family member 4 (Acsl4) and glutathione peroxidase 4 (GPX4). Similarly, Rosiglitazone, an inhibitor of Acsl4, administration alleviated the ovary damage of the mice undergoing chemotherapy. Further mechanistic investigation showed...
Source: Chemico-Biological Interactions - December 6, 2023 Category: Molecular Biology Authors: Siyuan Wang Xuqing Li Jun Li Aiping Wang Fangfang Li Huiqing Hu Tengfei Long Xueting Pei Hongyan Li Fei Zhong Fengyu Zhu Source Type: research
