Interfering TRIB3 protects the blood brain barrier through PI3K/Akt pathway to alleviate cerebral ischemia-reperfusion injury in diabetes mellitus mice
This study aimed to treat diabetic cerebral ischemia-reperfusion injury (CI/RI) by affecting blood brain barrier (BBB) permeability and integrity. The CI/RI model in DM mice and a high glucose (HG) treated oxygen and glucose deprivation/reoxygenation (OGD/R) brain endothelial cell model were established for the study. Evans blue (EB) staining was used to evaluate the permeability of BBB in vivo. TTC staining was used to analyze cerebral infarction. The location and expression of tribbles homolog 3 (TRIB3) in endothelial cells were detected by immunofluorescence. Western blotting was used to detect the protein expressions o...
Source: Chemico-Biological Interactions - November 19, 2023 Category: Molecular Biology Authors: Heng-Jun Zhou Xiao-Yi Wang Li-Qing Wang Jie-Sheng Zheng Ren-Ya Zhan Jian-Wei Pan Source Type: research
Cyclophosphamide reduces gene transcriptional activity and embryo in vitro development by inhibiting NF- κB expression through decreasing AcH4K12
This study aimed to investigate the potential impact of CTX on in vitro maturation (IVM) injury of porcine oocytes and subsequent embryonic development, as well as its effects on epigenetic modification and gene activation during early embryonic development. The results demonstrated that CTX treatment caused aberrant spindle structure and mitochondrial dysfunction during oocyte maturation, inducing DNA damage and early apoptosis, which consequently disrupted meiotic maturation. Indeed, CTX significantly reduced the in vitro developmental capacity of porcine embryos, and induced DNA damage and apoptosis in in vitro fertiliz...
Source: Chemico-Biological Interactions - November 19, 2023 Category: Molecular Biology Authors: Zhao-Bo Luo Liu-Hui Yang Sheng-Zhong Han Shuang-Yan Chang Hongye Liu Zhi-Yong An Xiu-Li Zhang Biao-Hu Quan Xi-Jun Yin Jin-Dan Kang Source Type: research
HIF-1 α: A potential therapeutic opportunity in renal fibrosis
This study reviews the regulation of HIF-1α and its mediated complex cascade reactions in renal fibrosis, and lists some drugs targeting HIF-1α that used in preclinical studies, to provide new insight for the study of the renal fibrosis mechanism.PMID:37980973 | DOI:10.1016/j.cbi.2023.110808 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - November 19, 2023 Category: Molecular Biology Authors: Disheng Liu Lu Wang Wuhua Ha Kan Li Rong Shen Degui Wang Source Type: research
Corrigendum to "Aluminum chloride induced splenic lymphocytes apoptosis through NF-kB inhibition" [Chemico-Biol. Interact. 257 (2016) 94-100]
Chem Biol Interact. 2023 Nov 16;387:110798. doi: 10.1016/j.cbi.2023.110798. Online ahead of print.NO ABSTRACTPMID:37979226 | DOI:10.1016/j.cbi.2023.110798 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - November 18, 2023 Category: Molecular Biology Authors: Cuicui Zhuang Hui Huo Wanfa Fu Wanyue Huang Lulu Han Miao Song Yanfei Li Source Type: research
Corrigendum to "Aluminum chloride induced splenic lymphocytes apoptosis through NF-kB inhibition" [Chemico-Biol. Interact. 257 (2016) 94-100]
Chem Biol Interact. 2023 Nov 16;387:110798. doi: 10.1016/j.cbi.2023.110798. Online ahead of print.NO ABSTRACTPMID:37979226 | DOI:10.1016/j.cbi.2023.110798 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - November 18, 2023 Category: Molecular Biology Authors: Cuicui Zhuang Hui Huo Wanfa Fu Wanyue Huang Lulu Han Miao Song Yanfei Li Source Type: research
