Effects of myricetin and quercetin on ticagrelor metabolism and the underlying mechanism
Chem Biol Interact. 2024 Feb 22:110924. doi: 10.1016/j.cbi.2024.110924. Online ahead of print.ABSTRACTThe aim of this study was to investigate the potential drug-drug interactions (DDIs) between ticagrelor and other drugs as well as their underlying mechanisms. Rat liver microsome (RLM) reaction system was used to screen potential DDIs in vitro, and ultra performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) was applied to detect the levels of ticagrelor and AR-C124910XX, the main metabolite of ticagrelor. A total of 68 drugs were screened, 11 of which inhibited the production of AR-C124910XX to 20% or le...
Source: Chemico-Biological Interactions - February 24, 2024 Category: Molecular Biology Authors: Jing Wang Yingying Hu Qingqing Li Ya-Nan Liu Jingjing Lin Ren-Ai Xu Source Type: research
SIRT6 activates PPAR α to improve doxorubicin-induced myocardial cell aging and damage
Chem Biol Interact. 2024 Feb 21:110920. doi: 10.1016/j.cbi.2024.110920. Online ahead of print.ABSTRACTThe Sirtuins family, formally known as the Silent Information Regulator Factors, constitutes a highly conserved group of histone deacetylases. Recent studies have illuminated SIRT6's role in doxorubicin (DOX)-induced oxidative stress and apoptosis within myocardial cells. Nevertheless, the extent of SIRT6's impact on DOX-triggered myocardial cell aging and damage remains uncertain, with the associated mechanisms yet to be fully understood. In our research, we examined the influence of SIRT6 on DOX-induced cardiomyocyte sen...
Source: Chemico-Biological Interactions - February 23, 2024 Category: Molecular Biology Authors: Shulin Wang Xuan Zhang Yanhong Hou Yuliang Zhang Jiamin Chen Shuhan Gao Huiying Duan Shaoju Gu Shanshan Yu Yi Cai Source Type: research
Natural bioactive compounds targeting DNA methyltransferase enzymes in cancer: Mechanisms insights and efficiencies
Chem Biol Interact. 2024 Feb 21:110907. doi: 10.1016/j.cbi.2024.110907. Online ahead of print.ABSTRACTThe regulation of gene expression is fundamental to health and life and is essentially carried out at the promoter region of the DNA of each gene. Depending on the molecular context, this region may be accessible or non-accessible (possibility of integration of RNA polymerase or not at this region). Among enzymes that control this process, DNA methyltransferase enzymes (DNMTs), are responsible for DNA demethylation at the CpG islands, particularly at the promoter regions, to regulate transcription. The aberrant activity of...
Source: Chemico-Biological Interactions - February 23, 2024 Category: Molecular Biology Authors: Tarik Aanniz Abdelhakim Bouyahya Abdelaali Balahbib Kawtar El Kadiri Asaad Khalid Hafiz A Makeen Hassan A Alhazmi Nasreddine El Omari Younes Zaid Rebecca Shin-Yee Wong Chien Ing Yeo Bey Hing Goh Saad Bakrim Source Type: research
SIRT6 activates PPAR α to improve doxorubicin-induced myocardial cell aging and damage
Chem Biol Interact. 2024 Feb 21:110920. doi: 10.1016/j.cbi.2024.110920. Online ahead of print.ABSTRACTThe Sirtuins family, formally known as the Silent Information Regulator Factors, constitutes a highly conserved group of histone deacetylases. Recent studies have illuminated SIRT6's role in doxorubicin (DOX)-induced oxidative stress and apoptosis within myocardial cells. Nevertheless, the extent of SIRT6's impact on DOX-triggered myocardial cell aging and damage remains uncertain, with the associated mechanisms yet to be fully understood. In our research, we examined the influence of SIRT6 on DOX-induced cardiomyocyte sen...
Source: Chemico-Biological Interactions - February 23, 2024 Category: Molecular Biology Authors: Shulin Wang Xuan Zhang Yanhong Hou Yuliang Zhang Jiamin Chen Shuhan Gao Huiying Duan Shaoju Gu Shanshan Yu Yi Cai Source Type: research
Natural bioactive compounds targeting DNA methyltransferase enzymes in cancer: Mechanisms insights and efficiencies
Chem Biol Interact. 2024 Feb 21:110907. doi: 10.1016/j.cbi.2024.110907. Online ahead of print.ABSTRACTThe regulation of gene expression is fundamental to health and life and is essentially carried out at the promoter region of the DNA of each gene. Depending on the molecular context, this region may be accessible or non-accessible (possibility of integration of RNA polymerase or not at this region). Among enzymes that control this process, DNA methyltransferase enzymes (DNMTs), are responsible for DNA demethylation at the CpG islands, particularly at the promoter regions, to regulate transcription. The aberrant activity of...
Source: Chemico-Biological Interactions - February 23, 2024 Category: Molecular Biology Authors: Tarik Aanniz Abdelhakim Bouyahya Abdelaali Balahbib Kawtar El Kadiri Asaad Khalid Hafiz A Makeen Hassan A Alhazmi Nasreddine El Omari Younes Zaid Rebecca Shin-Yee Wong Chien Ing Yeo Bey Hing Goh Saad Bakrim Source Type: research
Photoactivatable, mitochondria targeting dppz iridium(III) complex selectively interacts and damages mitochondrial DNA in cancer cells
Chem Biol Interact. 2024 Feb 19:110921. doi: 10.1016/j.cbi.2024.110921. Online ahead of print.ABSTRACTCyclometalated Ir(III) complex [Ir(L)2 (dppz)]PF6 (where L = 1-methyl-2-(thiophen-2-yl)-1H-benzo [d]imidazole and dppz = dipyrido [3,2-a:2',3'-c]phenazine) (Ir1) is potent anticancer agent whose potency can be significantly increased by irradiation with blue light. Structural features of the cyclometalated Ir(III) complex Ir1 investigated in this work, particularly the presence of dppz ligand possessing an extended planar area, suggest that this complex could interact with DNA. Here, we have shown that Ir1 accumulates pred...
Source: Chemico-Biological Interactions - February 21, 2024 Category: Molecular Biology Authors: Jana Kasparkova Vojtech Novohradsky Jos é Ruiz Viktor Brabec Source Type: research
Human CYP1A1-activated aneugenicity of aflatoxin B1 in mammalian cells and its combined effect with benzo(a)pyrene
In conclusion, AFB1 could be activated by human CYP1A1 for potent aneugenicity, which may be further enhanced by co-exposure to BaP.PMID:38382706 | DOI:10.1016/j.cbi.2024.110923 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - February 21, 2024 Category: Molecular Biology Authors: Huanhuan Wang Qin Fan Qian Liang Yao Wu Zhongming Ye Haipeng Wu Qian Sun Huanwen Tang Yungang Liu Qizhan Liu Yuting Chen Source Type: research
Photoactivatable, mitochondria targeting dppz iridium(III) complex selectively interacts and damages mitochondrial DNA in cancer cells
Chem Biol Interact. 2024 Feb 19:110921. doi: 10.1016/j.cbi.2024.110921. Online ahead of print.ABSTRACTCyclometalated Ir(III) complex [Ir(L)2 (dppz)]PF6 (where L = 1-methyl-2-(thiophen-2-yl)-1H-benzo [d]imidazole and dppz = dipyrido [3,2-a:2',3'-c]phenazine) (Ir1) is potent anticancer agent whose potency can be significantly increased by irradiation with blue light. Structural features of the cyclometalated Ir(III) complex Ir1 investigated in this work, particularly the presence of dppz ligand possessing an extended planar area, suggest that this complex could interact with DNA. Here, we have shown that Ir1 accumulates pred...
Source: Chemico-Biological Interactions - February 21, 2024 Category: Molecular Biology Authors: Jana Kasparkova Vojtech Novohradsky Jos é Ruiz Viktor Brabec Source Type: research
Human CYP1A1-activated aneugenicity of aflatoxin B1 in mammalian cells and its combined effect with benzo(a)pyrene
In conclusion, AFB1 could be activated by human CYP1A1 for potent aneugenicity, which may be further enhanced by co-exposure to BaP.PMID:38382706 | DOI:10.1016/j.cbi.2024.110923 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - February 21, 2024 Category: Molecular Biology Authors: Huanhuan Wang Qin Fan Qian Liang Yao Wu Zhongming Ye Haipeng Wu Qian Sun Huanwen Tang Yungang Liu Qizhan Liu Yuting Chen Source Type: research
Photoactivatable, mitochondria targeting dppz iridium(III) complex selectively interacts and damages mitochondrial DNA in cancer cells
Chem Biol Interact. 2024 Feb 19:110921. doi: 10.1016/j.cbi.2024.110921. Online ahead of print.ABSTRACTCyclometalated Ir(III) complex [Ir(L)2 (dppz)]PF6 (where L = 1-methyl-2-(thiophen-2-yl)-1H-benzo [d]imidazole and dppz = dipyrido [3,2-a:2',3'-c]phenazine) (Ir1) is potent anticancer agent whose potency can be significantly increased by irradiation with blue light. Structural features of the cyclometalated Ir(III) complex Ir1 investigated in this work, particularly the presence of dppz ligand possessing an extended planar area, suggest that this complex could interact with DNA. Here, we have shown that Ir1 accumulates pred...
Source: Chemico-Biological Interactions - February 21, 2024 Category: Molecular Biology Authors: Jana Kasparkova Vojtech Novohradsky Jos é Ruiz Viktor Brabec Source Type: research
Human CYP1A1-activated aneugenicity of aflatoxin B1 in mammalian cells and its combined effect with benzo(a)pyrene
In conclusion, AFB1 could be activated by human CYP1A1 for potent aneugenicity, which may be further enhanced by co-exposure to BaP.PMID:38382706 | DOI:10.1016/j.cbi.2024.110923 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - February 21, 2024 Category: Molecular Biology Authors: Huanhuan Wang Qin Fan Qian Liang Yao Wu Zhongming Ye Haipeng Wu Qian Sun Huanwen Tang Yungang Liu Qizhan Liu Yuting Chen Source Type: research
High incidence of sebaceous gland inflammation in aldose reductase-deficient mice
Chem Biol Interact. 2024 Feb 17:110905. doi: 10.1016/j.cbi.2024.110905. Online ahead of print.ABSTRACTAldose reductase is a member of the 1B1 subfamily of aldo-keto reductase gene superfamily. The action of aldose reductase (AR) has been implicated in the pathogenesis of a variety of disease states, most notably complications of diabetes mellitus including neuropathy, retinopathy, nephropathy, and cataracts. To explore for mechanistic roles for AR in disease pathogenesis, we established mutant strains produced using Crispr-Cas9 to inactivate the AKR1B3 gene in C57BL6 mice. Phenotyping AR-knock out (ARKO) strains confirmed ...
Source: Chemico-Biological Interactions - February 19, 2024 Category: Molecular Biology Authors: Anjali Mandava Binhan Pham Michelle Pedler Biehuoy Shieh Hari Gopalakrishnan J Mark Petrash Source Type: research
High incidence of sebaceous gland inflammation in aldose reductase-deficient mice
Chem Biol Interact. 2024 Feb 17:110905. doi: 10.1016/j.cbi.2024.110905. Online ahead of print.ABSTRACTAldose reductase is a member of the 1B1 subfamily of aldo-keto reductase gene superfamily. The action of aldose reductase (AR) has been implicated in the pathogenesis of a variety of disease states, most notably complications of diabetes mellitus including neuropathy, retinopathy, nephropathy, and cataracts. To explore for mechanistic roles for AR in disease pathogenesis, we established mutant strains produced using Crispr-Cas9 to inactivate the AKR1B3 gene in C57BL6 mice. Phenotyping AR-knock out (ARKO) strains confirmed ...
Source: Chemico-Biological Interactions - February 19, 2024 Category: Molecular Biology Authors: Anjali Mandava Binhan Pham Michelle Pedler Biehuoy Shieh Hari Gopalakrishnan J Mark Petrash Source Type: research
Assessment of anti-hyperglycemic and anti-hyperlipidemic effects of thiazolidine-2,4-dione derivatives in HFD-STZ diabetic animal model
In this study, we evaluated the metabolic effects of thiazolidine-2,4-dione derivatives in Wistar rats and Swiss mice that were fed a high-fat diet (HFD) for 4 weeks and received 90 mg/kg of streptozotocin (STZ) intraperitoneally as a T2DM model. The HFD consisted of 17% carbohydrate, 58% fat, and 25% protein, as a percentage of total kcal. The thiazolidine-2,4-dione derivatives treatments reduced fasting blood glucose (FBG) levels by an average of 23.98%-50.84%, which were also improved during the oral starch tolerance test (OSTT). Treatment with thiazolidine-2,4-dione derivatives also improved triglyceride (TG), low-dens...
Source: Chemico-Biological Interactions - February 17, 2024 Category: Molecular Biology Authors: Saad Fettach Fatima Zahra Thari Khalid Karrouchi Laila Benbacer Learn-Han Lee Abdelhakim Bouyahya Yahia Cherrah Hassan Sefrioui Khalid Bougrin My El Abbes Faouzi Source Type: research
Neurotoxicity of Pyrethroids in exacerbating neurodegenerative diseases: From animals' models to humans' studies
Chem Biol Interact. 2024 Feb 15:110911. doi: 10.1016/j.cbi.2024.110911. Online ahead of print.ABSTRACTNeurodegenerative diseases are associated with diverse symptoms, both motor and mental. Genetic and environmental factors can trigger neurodegenerative diseases. Chemicals as pesticides are constantly used in agriculture and also domestically. In this regard, pyrethroids (PY), are a class of insecticides in which its main mechanism of action is through disruption of voltage-dependent sodium channels function in insects. However, in mammals, they can also induce oxidative stress and enzyme dysfunction. This review investiga...
Source: Chemico-Biological Interactions - February 17, 2024 Category: Molecular Biology Authors: Rafael Arsuffi-Marcon Lizandra Gomes Souza Artur Santos-Miranda Julliane V Joviano-Santos Source Type: research
