New Ca < sup > 2+ < /sup > based anticancer nanomaterials trigger multiple cell death targeting Ca < sup > 2+ < /sup > homeostasis for cancer therapy
Chem Biol Interact. 2024 Mar 11:110948. doi: 10.1016/j.cbi.2024.110948. Online ahead of print.ABSTRACTCalcium ion (Ca2+) is a necessary element for human and Ca2+ homeostasis plays important roles in various cellular process and functions. Recent reaches have targeted on inducing Ca2+ overload (both intracellular and transcellular) for tumor therapy. With the development of nanotechnology, nanoplatform-mediated Ca2+ overload has been safe theranostic model for cancer therapy, and defined a special calcium overload-induced tumor cell death as "calcicoptosis". However, the underlying mechanism of calcicoptosis in cancer cell...
Source: Chemico-Biological Interactions - March 13, 2024 Category: Molecular Biology Authors: Junjie Liu Yimin Xie Jun Ma Hezhen Chu Source Type: research
The mechanism of anthracene degradation by tryptophan -2,3-dioxygenase (T23D) in Comamonas testosterone
Chem Biol Interact. 2024 Mar 11:110950. doi: 10.1016/j.cbi.2024.110950. Online ahead of print.ABSTRACTIt is well known that anthracene is a persistent organic pollutant. Among the four natural polycyclic aromatic hydrocarbons (PAHs) degrading strains, Comamonas testosterone (CT1) was selected as the strain with the highest degradation efficiency. In the present study, prokaryotic transcriptome analysis of CT1 revealed an increase in a gene that encodes tryptophane-2,3-dioxygenase (T23D) in the anthracene and erythromycin groups compared to CK. Compared to the wild-type CT1 strain, anthracene degradation by the CtT23D knock...
Source: Chemico-Biological Interactions - March 13, 2024 Category: Molecular Biology Authors: Miao Xu Xiao Yang Jinyuan Zhang Dong Liu Chuanzhi Zhang Ming Wu Elshan Musazade Edmund Maser Guangming Xiong Liquan Guo Source Type: research
Design, synthesis and mechanism study of coumarin-sulfonamide derivatives as carbonic anhydrase IX inhibitors with anticancer activity
In this study, twenty-nine coumarin-3-sulfonamide derivatives, twenty-seven of which are original were designed and synthesized. Cytotoxicity assay indicated that most of these derivatives exhibited moderated to good potency against A549 cells. Among them, compound 8q showed potent inhibition against the four tested cancer cell lines, especially A549 cells with IC50 value of 6.01 ± 0.81 μM, and much lower cytotoxicity on the normal cells was observed compared to the reference compounds. Bioinformatics analysis revealed human carbonic anhydrase IX (CAIX) was highly expressed in lung adenocarcinoma (LUAD) and associated wi...
Source: Chemico-Biological Interactions - March 13, 2024 Category: Molecular Biology Authors: Qianqian Lv Jing Zhang Jianghong Cai Lexian Chen Jiajie Liang Tianwan Zhang Jiahui Lin Ruiyao Chen Zhiling Zhang Peiting Guo Yue Hong Lingxue Pan Hong Ji Source Type: research
Protective role of forsythoside B in Kawasaki disease-induced cardiac injury: Inhibition of pyroptosis via the SIRT1-NF- κB-p65 signaling pathway
In this study, we investigated the effects of FTS-B on inflammation in cellular and murine models of KD. Our findings revealed that KD is associated with cardiac dysfunction and inflammatory injury to myocardial and human coronary artery endothelial cells (HCAECs), resulting in a pyroptosis-feedback loop. Both cellular and KD models were characterized by reduced SIRT1 expression and increased NF-κB p65 expression. Contrastingly, the rates of pyroptosis in both murine model myocardial tissues and HCAECs were significantly alleviated in response to FTS-B treatment. Also in both models, we detected an increase of SIRT1 expre...
Source: Chemico-Biological Interactions - March 12, 2024 Category: Molecular Biology Authors: Yitong Yang Nisha Wang Zhenyi Wang Miaomiao Zhao Luping Chen Zhaoling Shi Source Type: research
Protective role of forsythoside B in Kawasaki disease-induced cardiac injury: Inhibition of pyroptosis via the SIRT1-NF- κB-p65 signaling pathway
In this study, we investigated the effects of FTS-B on inflammation in cellular and murine models of KD. Our findings revealed that KD is associated with cardiac dysfunction and inflammatory injury to myocardial and human coronary artery endothelial cells (HCAECs), resulting in a pyroptosis-feedback loop. Both cellular and KD models were characterized by reduced SIRT1 expression and increased NF-κB p65 expression. Contrastingly, the rates of pyroptosis in both murine model myocardial tissues and HCAECs were significantly alleviated in response to FTS-B treatment. Also in both models, we detected an increase of SIRT1 expre...
Source: Chemico-Biological Interactions - March 12, 2024 Category: Molecular Biology Authors: Yitong Yang Nisha Wang Zhenyi Wang Miaomiao Zhao Luping Chen Zhaoling Shi Source Type: research
A systematic review on understanding the mechanistic pathways and clinical aspects of natural CDK inhibitors on cancer progression.: Unlocking cellular and biochemical mechanisms
Chem Biol Interact. 2024 Mar 9:110940. doi: 10.1016/j.cbi.2024.110940. Online ahead of print.ABSTRACTCell division, differentiation, and controlled cell death are all regulated by phosphorylation, a key biological function. This mechanism is controlled by a variety of enzymes, with cyclin-dependent kinases (CDKs) being particularly important in phosphorylating proteins at serine and threonine sites. CDKs, which contain 20 unique components, serve an important role in regulating vital physiological functions such as cell cycle progression and gene transcription. Methodologically, an extensive literature search was performed...
Source: Chemico-Biological Interactions - March 11, 2024 Category: Molecular Biology Authors: Andleeb Asghar Tahir Ali Chohan Umair Khurshid Hammad Saleem Mian Waqar Mustafa Anjum Khursheed Ahmed Alafnan Rahila Batul Mohammed Khaled Bin Break Khaled Almansour Sirajudheen Anwar Source Type: research
The copper transporter, SLC31A1, transcriptionally activated by ELF3, imbalances copper homeostasis to exacerbate cisplatin-induced acute kidney injury through mitochondrial dysfunction
This study explored the function of solute Carrier Family 31 Member 1 (SLC31A1) in cisplatin-induced AKI and its possible mechanism. Mice and HK-2 cells were exposed to cisplatin to establish the in vivo and in vitro AKI models. Cell viability was detected by CCK-8. Mitochondrial and oxidative damage was determined by Mito-Tracker Green staining, mtROS level, ATP production, mitochondrial membrane potential, MDA content and CAT activity. AKI was evaluated by renal function and histopathological changes. Apoptosis was detected by TUNEL and caspase-3 expression. Molecule expression was measured by RT-qPCR, Western blotting, ...
Source: Chemico-Biological Interactions - March 10, 2024 Category: Molecular Biology Authors: Zhimin Qiu Qicen Liu Ling Wang Yingfen Xiong Juan Wu Meijian Wang Xiluan Yan Huangying Deng Source Type: research
The copper transporter, SLC31A1, transcriptionally activated by ELF3, imbalances copper homeostasis to exacerbate cisplatin-induced acute kidney injury through mitochondrial dysfunction
This study explored the function of solute Carrier Family 31 Member 1 (SLC31A1) in cisplatin-induced AKI and its possible mechanism. Mice and HK-2 cells were exposed to cisplatin to establish the in vivo and in vitro AKI models. Cell viability was detected by CCK-8. Mitochondrial and oxidative damage was determined by Mito-Tracker Green staining, mtROS level, ATP production, mitochondrial membrane potential, MDA content and CAT activity. AKI was evaluated by renal function and histopathological changes. Apoptosis was detected by TUNEL and caspase-3 expression. Molecule expression was measured by RT-qPCR, Western blotting, ...
Source: Chemico-Biological Interactions - March 10, 2024 Category: Molecular Biology Authors: Zhimin Qiu Qicen Liu Ling Wang Yingfen Xiong Juan Wu Meijian Wang Xiluan Yan Huangying Deng Source Type: research
Transcriptomic and proteomic study of cancer cell lines exposed to actinomycin D and nutlin-3a reveals numerous, novel candidates for p53-regulated genes
In this study, using mass spectrometry and Western blotting, we detected expression of DRAXIN in a medium of A549 cells exposed to A + N. Thus, this protein functions not only in the development of the nervous system, but it may also have a new cancer-related function.PMID:38460933 | DOI:10.1016/j.cbi.2024.110946 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - March 9, 2024 Category: Molecular Biology Authors: Barbara Łasut-Szyszka Agnieszka Gdowicz-K łosok Beata Ma łachowska Ma łgorzata Krześniak Agnieszka B ędzińska Marta Gawin Monika Pietrowska Marek Rusin Source Type: research
Liposomal nanoformulations with trans-caryophyllene and caryophyllene oxide: do they have an inhibitory action on the efflux pumps NorA, Tet(K), MsrA, and MepA?
This study aimed to evaluate the antibacterial and inhibitory action of NorA, Tet(K), MsrA and MepA efflux pumps in S. aureus strains using the sesquiterpenes named trans-caryophyllene and caryophyllene oxide, both isolated and encapsulated in liposomes. The antibacterial and inhibitory action of these efflux pumps was evaluated through the serial microdilution test in 96-well microplates. Each sesquiterpene and liposome/sesquiterpene was combined with antibiotics and ethidium bromide (EtBr). The antibiotics named norfloxacin, tetracycline and erythromycin were used. The 1199 B, IS-58, RN4220 and K2068 S. aureus strains ca...
Source: Chemico-Biological Interactions - March 9, 2024 Category: Molecular Biology Authors: Jorge Ederson Gon çalves Santana C ícera Datiane de Morais Oliveira-Tintino Gabriel Gon çalves Alencar Gustavo Miguel Siqueira Jos é Weverton Almeida-Bezerra Jo ão Pedro Viana Rodrigues Vanessa Barbosa Pinheiro Gon çalves Roberto Nicolete Saulo Reli Source Type: research
Transcriptomic and proteomic study of cancer cell lines exposed to actinomycin D and nutlin-3a reveals numerous, novel candidates for p53-regulated genes
In this study, using mass spectrometry and Western blotting, we detected expression of DRAXIN in a medium of A549 cells exposed to A + N. Thus, this protein functions not only in the development of the nervous system, but it may also have a new cancer-related function.PMID:38460933 | DOI:10.1016/j.cbi.2024.110946 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - March 9, 2024 Category: Molecular Biology Authors: Barbara Łasut-Szyszka Agnieszka Gdowicz-K łosok Beata Ma łachowska Ma łgorzata Krześniak Agnieszka B ędzińska Marta Gawin Monika Pietrowska Marek Rusin Source Type: research
Liposomal nanoformulations with trans-caryophyllene and caryophyllene oxide: do they have an inhibitory action on the efflux pumps NorA, Tet(K), MsrA, and MepA?
This study aimed to evaluate the antibacterial and inhibitory action of NorA, Tet(K), MsrA and MepA efflux pumps in S. aureus strains using the sesquiterpenes named trans-caryophyllene and caryophyllene oxide, both isolated and encapsulated in liposomes. The antibacterial and inhibitory action of these efflux pumps was evaluated through the serial microdilution test in 96-well microplates. Each sesquiterpene and liposome/sesquiterpene was combined with antibiotics and ethidium bromide (EtBr). The antibiotics named norfloxacin, tetracycline and erythromycin were used. The 1199 B, IS-58, RN4220 and K2068 S. aureus strains ca...
Source: Chemico-Biological Interactions - March 9, 2024 Category: Molecular Biology Authors: Jorge Ederson Gon çalves Santana C ícera Datiane de Morais Oliveira-Tintino Gabriel Gon çalves Alencar Gustavo Miguel Siqueira Jos é Weverton Almeida-Bezerra Jo ão Pedro Viana Rodrigues Vanessa Barbosa Pinheiro Gon çalves Roberto Nicolete Saulo Reli Source Type: research
Comparing the oxidative functions of neutrophil myeloperoxidase and cytochrome P450 enzymes in drug metabolism
Chem Biol Interact. 2024 Mar 6:110942. doi: 10.1016/j.cbi.2024.110942. Online ahead of print.ABSTRACTDrug metabolism is an essential process that chemically alters xenobiotic substrates to activate or terminate drug activity. Myeloperoxidase (MPO) is a neutrophil-derived enzyme that is involved in killing invading pathogens, although consequentially, this same oxidative activity can produce metabolites that damage host tissue and play a role in various human pathologies. Cytochrome P450 (CYPs) are a superfamily of haem-containing enzymes that are majorly involved in the metabolism of drugs by functioning as monooxygenases ...
Source: Chemico-Biological Interactions - March 8, 2024 Category: Molecular Biology Authors: Newton H Tran Farag E S Mosa Khaled Barakat Ayman O S El-Kadi Randy Whittal Arno G Siraki Source Type: research
Assessments of carbon nanotubes toxicities in zebrafish larvae using multiple physiological and molecular endpoints
Chem Biol Interact. 2024 Mar 5:110925. doi: 10.1016/j.cbi.2024.110925. Online ahead of print.ABSTRACTIn recent years, carbon nanotubes (CNTs) have become one of the most promising materials for the technology industry. However, due to the extensive usage of these materials, they may be released into the environment, and cause toxicities to the organism. Here, their acute toxicities in zebrafish embryos and larvae were evaluated by using various assessments that may provide us with a novel perspective on their effects on aquatic animals. Before conducting the toxicity assessments, the CNTs were characterized as multiwall ca...
Source: Chemico-Biological Interactions - March 7, 2024 Category: Molecular Biology Authors: Gilbert Audira Jiann-Shing Lee Ross D Vasquez Marri Jmelou M Roldan Yu-Heng Lai Chung-Der Hsiao Source Type: research
Assessments of carbon nanotubes toxicities in zebrafish larvae using multiple physiological and molecular endpoints
Chem Biol Interact. 2024 Mar 5:110925. doi: 10.1016/j.cbi.2024.110925. Online ahead of print.ABSTRACTIn recent years, carbon nanotubes (CNTs) have become one of the most promising materials for the technology industry. However, due to the extensive usage of these materials, they may be released into the environment, and cause toxicities to the organism. Here, their acute toxicities in zebrafish embryos and larvae were evaluated by using various assessments that may provide us with a novel perspective on their effects on aquatic animals. Before conducting the toxicity assessments, the CNTs were characterized as multiwall ca...
Source: Chemico-Biological Interactions - March 7, 2024 Category: Molecular Biology Authors: Gilbert Audira Jiann-Shing Lee Ross D Vasquez Marri Jmelou M Roldan Yu-Heng Lai Chung-Der Hsiao Source Type: research
