Unveiling drug induced nephrotoxicity using novel biomarkers and cutting-edge preventive strategies
Chem Biol Interact. 2023 Dec 15:110838. doi: 10.1016/j.cbi.2023.110838. Online ahead of print.ABSTRACTDrug-induced nephrotoxicity is still a significant obstacle in pharmacotherapy of various diseases and it accounts for around 25 % of serious side-effects reported after drug administration. Furthermore, some groups of drugs such as nonsteroidal anti-inflammatory drugs, antibiotics, antiviral drugs, antifungal drugs, immunosuppressants, and chemotherapeutic drugs have the "preference" for damaging the kidney and are often referred to as the kidney's "silent killer". Clinically, the onset of acute kidney injury associated w...
Source: Chemico-Biological Interactions - December 17, 2023 Category: Molecular Biology Authors: Amina D židić-Krivić Emina K Sher Jasna Kusturica Esma K Farhat Asma Nawaz Farooq Sher Source Type: research
Thallium(I) induces a prolonged inhibition of (6-4)photoproduct binding and UV damage excision repair activities in zebrafish (Danio rerio) embryos via protein inactivation
Chem Biol Interact. 2023 Dec 15:110837. doi: 10.1016/j.cbi.2023.110837. Online ahead of print.ABSTRACTCyclobutane pyrimidine dimer (CPD) and (6-4)photoproduct (6-4PP) are two major types of UV-induced DNA lesion and 6-4PP is more mutagenic than CPD. Activated by lesion detection, nucleotide excision repair (NER) eliminates CPDs and 6-4PPs. Thallium (Tl) is a toxic metal existing primarily as Tl+ in the aquatic environment. Ingestion of Tl+-contaminated foods and water is a major route of human poisoning. As Tl+ may inhibit enzyme activities via binding to sulfhydryl groups, this study explored if Tl+ could intensify UV mut...
Source: Chemico-Biological Interactions - December 17, 2023 Category: Molecular Biology Authors: Ya-Yun Huang Ganjai Vikram Paul Todd Hsu Source Type: research
Unveiling drug induced nephrotoxicity using novel biomarkers and cutting-edge preventive strategies
Chem Biol Interact. 2023 Dec 15:110838. doi: 10.1016/j.cbi.2023.110838. Online ahead of print.ABSTRACTDrug-induced nephrotoxicity is still a significant obstacle in pharmacotherapy of various diseases and it accounts for around 25 % of serious side-effects reported after drug administration. Furthermore, some groups of drugs such as nonsteroidal anti-inflammatory drugs, antibiotics, antiviral drugs, antifungal drugs, immunosuppressants, and chemotherapeutic drugs have the "preference" for damaging the kidney and are often referred to as the kidney's "silent killer". Clinically, the onset of acute kidney injury associated w...
Source: Chemico-Biological Interactions - December 17, 2023 Category: Molecular Biology Authors: Amina D židić-Krivić Emina K Sher Jasna Kusturica Esma K Farhat Asma Nawaz Farooq Sher Source Type: research
Thallium(I) induces a prolonged inhibition of (6-4)photoproduct binding and UV damage excision repair activities in zebrafish (Danio rerio) embryos via protein inactivation
Chem Biol Interact. 2023 Dec 15:110837. doi: 10.1016/j.cbi.2023.110837. Online ahead of print.ABSTRACTCyclobutane pyrimidine dimer (CPD) and (6-4)photoproduct (6-4PP) are two major types of UV-induced DNA lesion and 6-4PP is more mutagenic than CPD. Activated by lesion detection, nucleotide excision repair (NER) eliminates CPDs and 6-4PPs. Thallium (Tl) is a toxic metal existing primarily as Tl+ in the aquatic environment. Ingestion of Tl+-contaminated foods and water is a major route of human poisoning. As Tl+ may inhibit enzyme activities via binding to sulfhydryl groups, this study explored if Tl+ could intensify UV mut...
Source: Chemico-Biological Interactions - December 17, 2023 Category: Molecular Biology Authors: Ya-Yun Huang Ganjai Vikram Paul Todd Hsu Source Type: research
Enhanced potency of a chloro-substituted polyaromatic platinum(II) complex and its platinum(IV) prodrug against lung cancer
Chem Biol Interact. 2023 Dec 14:110834. doi: 10.1016/j.cbi.2023.110834. Online ahead of print.ABSTRACTThe present study investigates the anti-neoplastic activity of a platinum(II) complex, Pt(II)5ClSS, and its platinum(IV) di-hydroxido analogue, Pt(IV)5ClSS, against mesenchymal cells (MCs), lung (A549), melanoma (A375) and breast (MDA-MB-231) cancer cells. Both complexes exhibited up to 14-fold improved cytotoxicity compared to cisplatin. NMR was used to determine that ∼25 % of Pt(IV)5ClSS was reduced to Pt(II)5ClSS in the presence of GSH (Glutathione) after 72 hr. The complex 1H NMR spectra acquired for Pt(II)5ClSS with...
Source: Chemico-Biological Interactions - December 16, 2023 Category: Molecular Biology Authors: Joy Baz Aleen Khoury Maria George Elias Najwa Mansour Stephanie Mehanna Omar Hammoud Christopher P Gordon Robin I Taleb Janice R Aldrich-Wright Costantine F Daher Source Type: research
Rosmarinic acid against cognitive impairment via RACK1/HIF-1 α regulated microglial polarization in sepsis-surviving mice
Chem Biol Interact. 2023 Dec 14:110830. doi: 10.1016/j.cbi.2023.110830. Online ahead of print.ABSTRACTMicroglial polarization modulation has been considered the potential therapeutic strategy for relieving cognitive impairment in sepsis survivors. Rosmarinic acid (RA), a water-soluble polyphenolic natural compound, processes a strong protective effect on various types of neurological disorders including Parkinson's disease, depression, and anxiety. However, its role and potential molecular mechanisms in sepsis-associated cognitive impairment remain unclear. To investigate the preventive and therapeutic effect of RA on seps...
Source: Chemico-Biological Interactions - December 16, 2023 Category: Molecular Biology Authors: Dan-Yang Liu Yao Wu Zi-Qi Feng Yang Yu Hua-Wei Cai Shi-Ping Liao Tao Zeng Ling Zhu Xia Wang Li-Hong Wan Source Type: research
Noncovalent binding of carbofuran to acetylcholinesterase from Homo sapiens, Danio rerio, Apis mellifera and Caenorhabditis elegans: Homology modelling, molecular docking and dynamics, and quantum biochemistry description
Chem Biol Interact. 2023 Dec 13;388:110826. doi: 10.1016/j.cbi.2023.110826. Online ahead of print.ABSTRACTAlthough various regulatory agencies have banned or severely restricted the use of carbofuran (CAR), recent reports indicate the presence of CAR residues in both cultivated and wild areas. This pesticide is a potent inhibitor of acetylcholinesterase (AChE), which acts by preventing the hydrolysis of acetylcholine (ACh). Given the critical role of AChE::ACh in the proper functioning of the nervous system, we thought it appropriate to investigate the binding of CAR to AChEs from Homo sapiens, Danio rerio, Apis mellifera,...
Source: Chemico-Biological Interactions - December 15, 2023 Category: Molecular Biology Authors: Jo ão P C Veras Victor L B Fran ça Hernandes F Carvalho Valder N Freire Source Type: research
BDE-47-mediated cytotoxicity via autophagy blockade in 3D HepaRG spheroids cultured in alginate microcapsules
Chem Biol Interact. 2023 Dec 13;388:110831. doi: 10.1016/j.cbi.2023.110831. Online ahead of print.ABSTRACTPolybrominated Diphenyl Ethers (PBDEs) are a major class of brominated flame retardants, and their widespread use has led them to be considered contaminants with emerging concern. PBDEs have been detected in the indoor air, house dust, food, and all environmental compartments. The congener BDE-47 (2,2',4,4'-tetrabromodiphenyl ether) is the most prevalent, and hepatotoxicity, neurotoxicity, immunological changes, endocrine disruption, and genotoxic potential have been related to its exposure. Although the BDE-47 molecul...
Source: Chemico-Biological Interactions - December 15, 2023 Category: Molecular Biology Authors: Raul Ghiraldelli Miranda Gabriel Cicolin Guarache Anderson Henrique F F Le ão Gustavo Jos é Pereira Daniel Junqueira Dorta Source Type: research
Sunitinib induces cardiotoxicity through modulating oxidative stress and Nrf2-dependent ferroptosis in vitro and in vivo
This study suggested that oxidative stress and Nrf2-dependent ferroptosis played a vital role in SUN-induced cardiotoxicity.PMID:38101598 | DOI:10.1016/j.cbi.2023.110829 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - December 15, 2023 Category: Molecular Biology Authors: Dongjie Li Chengzhu Song Chunpu Song Xinrui Tian Huaibo Zhang Jie Zhang Xiaoyan Zhao Source Type: research
AMPK α is active in autophagy of endothelial cells in arsenic-induced vascular endothelial dysfunction by regulating mTORC1\ p70S6K\ULK1
Chem Biol Interact. 2023 Dec 13:110832. doi: 10.1016/j.cbi.2023.110832. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is the most common cause of death, environmental factors, such as arsenic, playing an important role in the progress of CVD. Vascular endothelial dysfunction (VED) is a crucial early feature for CVD, inorganic arsenic (iAs) can induce autophagy in various cells. However, the role of endothelial autophagy has rarely been studied in VED triggered by arsenic. Total of one hundred and twenty healthy male C57BL/6J mice weighing 18-22 g were randomly divided into an arsenic-exposure group and a contr...
Source: Chemico-Biological Interactions - December 15, 2023 Category: Molecular Biology Authors: Ziqi Xu Qiaoling Liu Jinyu Li Jingqiu Wang Zhihan Yang Juan Wang Lin Gao Jin Cheng Jing He Yishan Dong Xiangnan Guo Jing Cui Wei Zhang Source Type: research
Amino acid derivative of probenecid potentiates apoptosis-inducing effects of vinblastine by increasing oxidative stress in a cancer cell-specific manner
Chem Biol Interact. 2023 Dec 13:110833. doi: 10.1016/j.cbi.2023.110833. Online ahead of print.ABSTRACTMany chemotherapeutic drugs suffer from multidrug resistance (MDR). Efflux transporters, namely ATP-binding cassettes (ABCs), that pump the drugs out of the cancer cells comprise one major reason behind MDR. Therefore, ABC inhibitors have been under development for ages, but unfortunately, without clinical success. In the present study, an L-type amino acid transporter 1 (LAT1)-utilizing derivative of probenecid (PRB) was developed as a cancer cell-targeted efflux inhibitor for P-glycoprotein (P-gp), breast cancer resistan...
Source: Chemico-Biological Interactions - December 15, 2023 Category: Molecular Biology Authors: Johanna Huttunen Janne Tampio Juulia J ärvinen Ahmed B Montaser Magdalena Markowicz-Piasecka Kristiina M Huttunen Source Type: research
Noncovalent binding of carbofuran to acetylcholinesterase from Homo sapiens, Danio rerio, Apis mellifera and Caenorhabditis elegans: Homology modelling, molecular docking and dynamics, and quantum biochemistry description
Chem Biol Interact. 2023 Dec 13:110826. doi: 10.1016/j.cbi.2023.110826. Online ahead of print.ABSTRACTAlthough various regulatory agencies have banned or severely restricted the use of carbofuran (CAR), recent reports indicate the presence of CAR residues in both cultivated and wild areas. This pesticide is a potent inhibitor of acetylcholinesterase (AChE), which acts by preventing the hydrolysis of acetylcholine (ACh). Given the critical role of AChE::ACh in the proper functioning of the nervous system, we thought it appropriate to investigate the binding of CAR to AChEs from Homo sapiens, Danio rerio, Apis mellifera, and...
Source: Chemico-Biological Interactions - December 15, 2023 Category: Molecular Biology Authors: Jo ão P C Veras Victor L B Fran ça Hernandes F Carvalho Valder N Freire Source Type: research
BDE-47-mediated cytotoxicity via autophagy blockade in 3D HepaRG spheroids cultured in alginate microcapsules
Chem Biol Interact. 2023 Dec 13:110831. doi: 10.1016/j.cbi.2023.110831. Online ahead of print.ABSTRACTPolybrominated Diphenyl Ethers (PBDEs) are a major class of brominated flame retardants, and their widespread use has led them to be considered contaminants with emerging concern. PBDEs have been detected in the indoor air, house dust, food, and all environmental compartments. The congener BDE-47 (2,2',4,4'-tetrabromodiphenyl ether) is the most prevalent, and hepatotoxicity, neurotoxicity, immunological changes, endocrine disruption, and genotoxic potential have been related to its exposure. Although the BDE-47 molecular t...
Source: Chemico-Biological Interactions - December 15, 2023 Category: Molecular Biology Authors: Raul Ghiraldelli Miranda Gabriel Cicolin Guarache Anderson Henrique F F Le ão Gustavo Jos é da Silva Pereira Daniel Junqueira Dorta Source Type: research
Sunitinib induces cardiotoxicity through modulating oxidative stress and Nrf2-dependent ferroptosis in vitro and in vivo
This study suggested that oxidative stress and Nrf2-dependent ferroptosis played a vital role in SUN-induced cardiotoxicity.PMID:38101598 | DOI:10.1016/j.cbi.2023.110829 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - December 15, 2023 Category: Molecular Biology Authors: Dongjie Li Chengzhu Song Chunpu Song Xinrui Tian Huaibo Zhang Jie Zhang Xiaoyan Zhao Source Type: research
AMPK α is active in autophagy of endothelial cells in arsenic-induced vascular endothelial dysfunction by regulating mTORC1\ p70S6K\ULK1
Chem Biol Interact. 2023 Dec 13:110832. doi: 10.1016/j.cbi.2023.110832. Online ahead of print.ABSTRACTCardiovascular disease (CVD) is the most common cause of death, environmental factors, such as arsenic, playing an important role in the progress of CVD. Vascular endothelial dysfunction (VED) is a crucial early feature for CVD, inorganic arsenic (iAs) can induce autophagy in various cells. However, the role of endothelial autophagy has rarely been studied in VED triggered by arsenic. Total of one hundred and twenty healthy male C57BL/6J mice weighing 18-22 g were randomly divided into an arsenic-exposure group and a contr...
Source: Chemico-Biological Interactions - December 15, 2023 Category: Molecular Biology Authors: Ziqi Xu Qiaoling Liu Jinyu Li Jingqiu Wang Zhihan Yang Juan Wang Lin Gao Jin Cheng Jing He Yishan Dong Xiangnan Guo Jing Cui Wei Zhang Source Type: research
