Nickel induces mitochondrial damage in renal cells in vitro and in vivo through its effects on mitochondrial biogenesis, fusion, and fission
This study provided novel insights into the mechanisms of nephrotoxicity of Ni and new ideas for the development of targeted treatments for Ni-induced kidney injury.PMID:38552765 | DOI:10.1016/j.cbi.2024.110975 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - March 29, 2024 Category: Molecular Biology Authors: Heng Yin Xinglai Li Chengbi Wang Xiaocong Li Jingbo Liu Source Type: research
Probing the anti-A β42 aggregation and protective effects of prenylated xanthone against Aβ42-induced toxicity in transgenic Caenorhabditis elegans model
In this study, we used a comprehensive approach encompassing in vitro assays, computational analyses, and an in vivo Caenorhabditis elegans model to evaluate the inhibitory effects of various xanthones, focusing on Garcinone D (GD), on Aβ42 oligomer formation. Dot blot analysis revealed concentration-dependent responses among xanthones, with GD consistently inhibiting Aβ42 oligomer formation at low concentrations (0.1 and 0.5 μM, inhibitions of 84.66 ± 2.25% and 85.06 ± 6.57%, respectively). Molecular docking and dynamics simulations provided insights into the molecular interactions between xanthones and Aβ42, highli...
Source: Chemico-Biological Interactions - March 29, 2024 Category: Molecular Biology Authors: Hin Yee Thew Khor Boon Keat Yong Chiang Tan Yong Sze Ong Marie-Odile Parat Vikneswaran Murugaiyah Bey Hing Goh Kooi Yeong Khaw Source Type: research
Interaction of 3,9-disubstituted acridine with single stranded poly(rA), double stranded poly(rAU) and triple stranded poly(rUAU): molecular docking - A spectroscopic tandem study
Chem Biol Interact. 2024 Mar 27:110965. doi: 10.1016/j.cbi.2024.110965. Online ahead of print.ABSTRACTRNA plays an important role in many biological processes which are crucial for cell survival, and it has been suggested that it may be possible to inhibit individual processes involved in many diseases by targeting specific sequences of RNA. The aim of this work is to determine the affinity of novel 3,9-disubstited acridine derivative 1 with three different RNA molecules, namely single stranded poly(rA), double stranded homopolymer poly(rAU) and triple stranded poly(rUAU). The results of the absorption titration assays sho...
Source: Chemico-Biological Interactions - March 29, 2024 Category: Molecular Biology Authors: Krist ína Krochtová Ladislav Janovec Vikt ória Bogárová Annam ária Halečková M ária Kožurková Source Type: research
Genotoxicity and heating Performance of V < sub > x < /sub > Fe < sub > 3-x < /sub > O < sub > 4 < /sub > nanoparticles in Health applications
Chem Biol Interact. 2024 Mar 26:110977. doi: 10.1016/j.cbi.2024.110977. Online ahead of print.ABSTRACTThe applications of magnetic nanoparticles (MNPs) as biocatalysts in different biomedical areas have been evolved very recently. One of the main challenges in this field is to design affective MNPs surfaces with catalytically active atomic centres, while producing minimal toxicological side effects on the hosting cell or tissues. MNPs of vanadium spinel ferrite (VFe2O4) are a promising material for mimicking the action of natural enzymes in degrading harmful substrates due to the presence of active V5+ centres. However, th...
Source: Chemico-Biological Interactions - March 28, 2024 Category: Molecular Biology Authors: Beatriz Sanz-Sagu é Amaia S áenz-Hernández A C Moreno Maldonado Jes ús A Fuentes-García Jorge M Nu ñez Bojana Zegura Alja Stern Katja Kolosa Iza Rozman Teobaldo E Torres Gerardo F Goya Source Type: research
Genotoxicity and heating Performance of V < sub > x < /sub > Fe < sub > 3-x < /sub > O < sub > 4 < /sub > nanoparticles in Health applications
Chem Biol Interact. 2024 Mar 26:110977. doi: 10.1016/j.cbi.2024.110977. Online ahead of print.ABSTRACTThe applications of magnetic nanoparticles (MNPs) as biocatalysts in different biomedical areas have been evolved very recently. One of the main challenges in this field is to design affective MNPs surfaces with catalytically active atomic centres, while producing minimal toxicological side effects on the hosting cell or tissues. MNPs of vanadium spinel ferrite (VFe2O4) are a promising material for mimicking the action of natural enzymes in degrading harmful substrates due to the presence of active V5+ centres. However, th...
Source: Chemico-Biological Interactions - March 28, 2024 Category: Molecular Biology Authors: Beatriz Sanz-Sagu é Amaia S áenz-Hernández A C Moreno Maldonado Jes ús A Fuentes-García Jorge M Nu ñez Bojana Zegura Alja Stern Katja Kolosa Iza Rozman Teobaldo E Torres Gerardo F Goya Source Type: research
Fluorescence study of the interaction between albumin and layered double hydroxides
Chem Biol Interact. 2024 Mar 22;394:110974. doi: 10.1016/j.cbi.2024.110974. Online ahead of print.ABSTRACTLayered double hydroxides nanoparticles (LDH-NP) are increasingly studied for biomedical applications. Nevertheless, their interaction with biomolecules such as proteins needs further exploration for an effective application. In this work, the adsorption of bovine serum albumin (BSA) on LDH-NP and the conformation changes of the protein upon adsorption were characterized using fluorescence spectroscopy. First, the quenching of tryptophan residues of BSA by chloride-intercalated LDH-NP was explored and the BSA adsorptio...
Source: Chemico-Biological Interactions - March 24, 2024 Category: Molecular Biology Authors: Cecilia Vasti Corina Marengo-Viada Carla E Giacomelli Ricardo Rojas Source Type: research
Morusin inhibits breast cancer-induced osteolysis by decreasing phosphatidylinositol 3-kinase (PI3K)-mTOR signalling
This study is the first to report that MOR can prevent osteolysis induced by breast cancer cells. Specifically, our results revealed that MOR inhibits RANKL-induced osteoclastogenesis and restrains the proliferation, invasion and migration of MDA-MB-231 breast cells through restraining the PI3K/AKT/MTOR signalling pathway. Notably, MOR prevented bone loss caused by breast cancer cell-induced osteolysis in vivo, indicating that MOR inhibited the development of OCs and the resorption of bone, which are essential for cancer cell-associated bone distraction. This study showed that MOR treatment inhibited osteolysis induced by ...
Source: Chemico-Biological Interactions - March 24, 2024 Category: Molecular Biology Authors: Long Zhang Weibin Li Xiaohui Chen Dongmin Cao Siyuan You Fan Shi Zhengqiong Luo Hongyu Li Xiangchen Zeng Yabin Song Na Li Yoshie Akimoto Gang Rui Yu Chen Zuoxing Wu Ren Xu Source Type: research
Astragalus polysaccharides ameliorates experimental colitis by regulating memory B cells metabolism
Chem Biol Interact. 2024 Mar 24;394:110969. doi: 10.1016/j.cbi.2024.110969. Online ahead of print.ABSTRACTIt is well-established that the reduced Memory B cells (MBCs) play an important role in the pathogenesis of ulcerative colitis (UC), rendering them a potential therapeutic target for UC intervention. Astragalus polysaccharide (APS), a primary active constituent derived from the classic traditional Chinese medicine Astragalus membranaceus (AM), has been used for centuries in the treatment of UC in both human and animal subjects due to its renowned immunomodulatory properties. However, it is unknown whether APS can regul...
Source: Chemico-Biological Interactions - March 24, 2024 Category: Molecular Biology Authors: Yifei Deng Lizhao Song Jiaqi Huang Wen Zhou Yali Liu Xiuyun Lu Haimei Zhao Duanyong Liu Source Type: research
Fluorescence study of the interaction between albumin and layered double hydroxides
Chem Biol Interact. 2024 Mar 22:110974. doi: 10.1016/j.cbi.2024.110974. Online ahead of print.ABSTRACTLayered double hydroxides nanoparticles (LDH-NP) are increasingly studied for biomedical applications. Nevertheless, their interaction with biomolecules such as proteins needs further exploration for an effective application. In this work, the adsorption of bovine serum albumin (BSA) on LDH-NP and the conformation changes of the protein upon adsorption were characterized using fluorescence spectroscopy. First, the quenching of tryptophan residues of BSA by chloride-intercalated LDH-NP was explored and the BSA adsorption ca...
Source: Chemico-Biological Interactions - March 24, 2024 Category: Molecular Biology Authors: Cecilia Vasti Corina Marengo-Viada Carla E Giacomelli Ricardo Rojas Source Type: research
Morusin inhibits breast cancer-induced osteolysis by decreasing phosphatidylinositol 3-kinase (PI3K)-mTOR signalling
This study is the first to report that MOR can prevent osteolysis induced by breast cancer cells. Specifically, our results revealed that MOR inhibits RANKL-induced osteoclastogenesis and restrains the proliferation, invasion and migration of MDA-MB-231 breast cells through restraining the PI3K/AKT/MTOR signalling pathway. Notably, MOR prevented bone loss caused by breast cancer cell-induced osteolysis in vivo, indicating that MOR inhibited the development of OCs and the resorption of bone, which are essential for cancer cell-associated bone distraction. This study showed that MOR treatment inhibited osteolysis induced by ...
Source: Chemico-Biological Interactions - March 24, 2024 Category: Molecular Biology Authors: Long Zhang Weibin Li Xiaohui Chen Dongmin Cao Siyuan You Fan Shi Zhengqiong Luo Hongyu Li Xiangchen Zeng Yabin Song Na Li Yoshie Akimoto Gang Rui Yu Chen Zuoxing Wu Ren Xu Source Type: research
Astragalus polysaccharides ameliorates experimental colitis by regulating memory B cells metabolism
Chem Biol Interact. 2024 Mar 24;394:110969. doi: 10.1016/j.cbi.2024.110969. Online ahead of print.ABSTRACTIt is well-established that the reduced Memory B cells (MBCs) play an important role in the pathogenesis of ulcerative colitis (UC), rendering them a potential therapeutic target for UC intervention. Astragalus polysaccharide (APS), a primary active constituent derived from the classic traditional Chinese medicine Astragalus membranaceus (AM), has been used for centuries in the treatment of UC in both human and animal subjects due to its renowned immunomodulatory properties. However, it is unknown whether APS can regul...
Source: Chemico-Biological Interactions - March 24, 2024 Category: Molecular Biology Authors: Yifei Deng Lizhao Song Jiaqi Huang Wen Zhou Yali Liu Xiuyun Lu Haimei Zhao Duanyong Liu Source Type: research
Fluorescence study of the interaction between albumin and layered double hydroxides
Chem Biol Interact. 2024 Mar 22:110974. doi: 10.1016/j.cbi.2024.110974. Online ahead of print.ABSTRACTLayered double hydroxides nanoparticles (LDH-NP) are increasingly studied for biomedical applications. Nevertheless, their interaction with biomolecules such as proteins needs further exploration for an effective application. In this work, the adsorption of bovine serum albumin (BSA) on LDH-NP and the conformation changes of the protein upon adsorption were characterized using fluorescence spectroscopy. First, the quenching of tryptophan residues of BSA by chloride-intercalated LDH-NP was explored and the BSA adsorption ca...
Source: Chemico-Biological Interactions - March 24, 2024 Category: Molecular Biology Authors: Cecilia Vasti Corina Marengo-Viada Carla E Giacomelli Ricardo Rojas Source Type: research
Morusin inhibits breast cancer-induced osteolysis by decreasing phosphatidylinositol 3-kinase (PI3K)-mTOR signalling
This study is the first to report that MOR can prevent osteolysis induced by breast cancer cells. Specifically, our results revealed that MOR inhibits RANKL-induced osteoclastogenesis and restrains the proliferation, invasion and migration of MDA-MB-231 breast cells through restraining the PI3K/AKT/MTOR signalling pathway. Notably, MOR prevented bone loss caused by breast cancer cell-induced osteolysis in vivo, indicating that MOR inhibited the development of OCs and the resorption of bone, which are essential for cancer cell-associated bone distraction. This study showed that MOR treatment inhibited osteolysis induced by ...
Source: Chemico-Biological Interactions - March 24, 2024 Category: Molecular Biology Authors: Long Zhang Weibin Li Xiaohui Chen Dongmin Cao Siyuan You Fan Shi Zhengqiong Luo Hongyu Li Xiangchen Zeng Yabin Song Na Li Yoshie Akimoto Gang Rui Yu Chen Zuoxing Wu Ren Xu Source Type: research
Astragalus polysaccharides ameliorates experimental colitis by regulating memory B cells metabolism
Chem Biol Interact. 2024 Mar 22:110969. doi: 10.1016/j.cbi.2024.110969. Online ahead of print.ABSTRACTIt is well-established that the reduced Memory B cells (MBCs) play an important role in the pathogenesis of ulcerative colitis (UC), rendering them a potential therapeutic target for UC intervention. Astragalus polysaccharide (APS), a primary active constituent derived from the classic traditional Chinese medicine Astragalus membranaceus (AM), has been used for centuries in the treatment of UC in both human and animal subjects due to its renowned immunomodulatory properties. However, it is unknown whether APS can regulate ...
Source: Chemico-Biological Interactions - March 24, 2024 Category: Molecular Biology Authors: Yifei Deng Lizhao Song Jiaqi Huang Wen Zhou Yali Liu Xiuyun Lu Haimei Zhao Duanyong Liu Source Type: research
Fluorescence study of the interaction between albumin and layered double hydroxides
Chem Biol Interact. 2024 Mar 22:110974. doi: 10.1016/j.cbi.2024.110974. Online ahead of print.ABSTRACTLayered double hydroxides nanoparticles (LDH-NP) are increasingly studied for biomedical applications. Nevertheless, their interaction with biomolecules such as proteins needs further exploration for an effective application. In this work, the adsorption of bovine serum albumin (BSA) on LDH-NP and the conformation changes of the protein upon adsorption were characterized using fluorescence spectroscopy. First, the quenching of tryptophan residues of BSA by chloride-intercalated LDH-NP was explored and the BSA adsorption ca...
Source: Chemico-Biological Interactions - March 24, 2024 Category: Molecular Biology Authors: Cecilia Vasti Corina Marengo-Viada Carla E Giacomelli Ricardo Rojas Source Type: research
