High incidence of sebaceous gland inflammation in aldose reductase-deficient mice
Chem Biol Interact. 2024 Feb 17:110905. doi: 10.1016/j.cbi.2024.110905. Online ahead of print.ABSTRACTAldose reductase is a member of the 1B1 subfamily of aldo-keto reductase gene superfamily. The action of aldose reductase (AR) has been implicated in the pathogenesis of a variety of disease states, most notably complications of diabetes mellitus including neuropathy, retinopathy, nephropathy, and cataracts. To explore for mechanistic roles for AR in disease pathogenesis, we established mutant strains produced using Crispr-Cas9 to inactivate the AKR1B3 gene in C57BL6 mice. Phenotyping AR-knock out (ARKO) strains confirmed ...
Source: Chemico-Biological Interactions - February 19, 2024 Category: Molecular Biology Authors: Anjali Mandava Binhan Pham Michelle Pedler Biehuoy Shieh Hari Gopalakrishnan J Mark Petrash Source Type: research
Assessment of anti-hyperglycemic and anti-hyperlipidemic effects of thiazolidine-2,4-dione derivatives in HFD-STZ diabetic animal model
In this study, we evaluated the metabolic effects of thiazolidine-2,4-dione derivatives in Wistar rats and Swiss mice that were fed a high-fat diet (HFD) for 4 weeks and received 90 mg/kg of streptozotocin (STZ) intraperitoneally as a T2DM model. The HFD consisted of 17% carbohydrate, 58% fat, and 25% protein, as a percentage of total kcal. The thiazolidine-2,4-dione derivatives treatments reduced fasting blood glucose (FBG) levels by an average of 23.98%-50.84%, which were also improved during the oral starch tolerance test (OSTT). Treatment with thiazolidine-2,4-dione derivatives also improved triglyceride (TG), low-dens...
Source: Chemico-Biological Interactions - February 17, 2024 Category: Molecular Biology Authors: Saad Fettach Fatima Zahra Thari Khalid Karrouchi Laila Benbacer Learn-Han Lee Abdelhakim Bouyahya Yahia Cherrah Hassan Sefrioui Khalid Bougrin My El Abbes Faouzi Source Type: research
Neurotoxicity of Pyrethroids in exacerbating neurodegenerative diseases: From animals' models to humans' studies
Chem Biol Interact. 2024 Feb 15:110911. doi: 10.1016/j.cbi.2024.110911. Online ahead of print.ABSTRACTNeurodegenerative diseases are associated with diverse symptoms, both motor and mental. Genetic and environmental factors can trigger neurodegenerative diseases. Chemicals as pesticides are constantly used in agriculture and also domestically. In this regard, pyrethroids (PY), are a class of insecticides in which its main mechanism of action is through disruption of voltage-dependent sodium channels function in insects. However, in mammals, they can also induce oxidative stress and enzyme dysfunction. This review investiga...
Source: Chemico-Biological Interactions - February 17, 2024 Category: Molecular Biology Authors: Rafael Arsuffi-Marcon Lizandra Gomes Souza Artur Santos-Miranda Julliane V Joviano-Santos Source Type: research
Loss of VRK1 alters the nuclear phosphoproteome in the DNA damage response to doxorubicin
Chem Biol Interact. 2024 Feb 15:110908. doi: 10.1016/j.cbi.2024.110908. Online ahead of print.ABSTRACTDynamic chromatin remodeling requires regulatory mechanisms for its adaptation to different nuclear function, which are likely to be mediated by signaling proteins. In this context, VRK1 is a nuclear Ser-Thr kinase that regulates pathways associated with transcription, replication, recombination, and DNA repair. Therefore, VRK1 is a potential regulatory, or coordinator, molecule in these processes. In this work we studied the effect that VRK1 depletion has on the basal nuclear and chromatin phosphoproteome, and their assoc...
Source: Chemico-Biological Interactions - February 17, 2024 Category: Molecular Biology Authors: Elena Navarro-Carrasco Aurora Campos-D íaz Eva Monte-Serrano Frank Rolfs Richard de Goeij-de Haas Thang V Pham Sander R Piersma Connie R Jim énez Pedro A Lazo Source Type: research
Assessment of anti-hyperglycemic and anti-hyperlipidemic effects of thiazolidine-2,4-dione derivatives in HFD-STZ diabetic animal model
In this study, we evaluated the metabolic effects of thiazolidine-2,4-dione derivatives in Wistar rats and Swiss mice that were fed a high-fat diet (HFD) for 4 weeks and received 90 mg/kg of streptozotocin (STZ) intraperitoneally as a T2DM model. The HFD consisted of 17% carbohydrate, 58% fat, and 25% protein, as a percentage of total kcal. The thiazolidine-2,4-dione derivatives treatments reduced fasting blood glucose (FBG) levels by an average of 23.98%-50.84%, which were also improved during the oral starch tolerance test (OSTT). Treatment with thiazolidine-2,4-dione derivatives also improved triglyceride (TG), low-dens...
Source: Chemico-Biological Interactions - February 17, 2024 Category: Molecular Biology Authors: Saad Fettach Fatima Zahra Thari Khalid Karrouchi Laila Benbacer Learn-Han Lee Abdelhakim Bouyahya Yahia Cherrah Hassan Sefrioui Khalid Bougrin My El Abbes Faouzi Source Type: research
Neurotoxicity of Pyrethroids in exacerbating neurodegenerative diseases: From animals' models to humans' studies
Chem Biol Interact. 2024 Feb 15:110911. doi: 10.1016/j.cbi.2024.110911. Online ahead of print.ABSTRACTNeurodegenerative diseases are associated with diverse symptoms, both motor and mental. Genetic and environmental factors can trigger neurodegenerative diseases. Chemicals as pesticides are constantly used in agriculture and also domestically. In this regard, pyrethroids (PY), are a class of insecticides in which its main mechanism of action is through disruption of voltage-dependent sodium channels function in insects. However, in mammals, they can also induce oxidative stress and enzyme dysfunction. This review investiga...
Source: Chemico-Biological Interactions - February 17, 2024 Category: Molecular Biology Authors: Rafael Arsuffi-Marcon Lizandra Gomes Souza Artur Santos-Miranda Julliane V Joviano-Santos Source Type: research
Loss of VRK1 alters the nuclear phosphoproteome in the DNA damage response to doxorubicin
Chem Biol Interact. 2024 Feb 15:110908. doi: 10.1016/j.cbi.2024.110908. Online ahead of print.ABSTRACTDynamic chromatin remodeling requires regulatory mechanisms for its adaptation to different nuclear function, which are likely to be mediated by signaling proteins. In this context, VRK1 is a nuclear Ser-Thr kinase that regulates pathways associated with transcription, replication, recombination, and DNA repair. Therefore, VRK1 is a potential regulatory, or coordinator, molecule in these processes. In this work we studied the effect that VRK1 depletion has on the basal nuclear and chromatin phosphoproteome, and their assoc...
Source: Chemico-Biological Interactions - February 17, 2024 Category: Molecular Biology Authors: Elena Navarro-Carrasco Aurora Campos-D íaz Eva Monte-Serrano Frank Rolfs Richard de Goeij-de Haas Thang V Pham Sander R Piersma Connie R Jim énez Pedro A Lazo Source Type: research
Sodium aescinate induces renal toxicity by promoting Nrf2/GPX4-mediated ferroptosis
Chem Biol Interact. 2024 Feb 15;391:110892. doi: 10.1016/j.cbi.2024.110892. Online ahead of print.ABSTRACTSodium aescinate (SA) is extracted from Aesculus wilsonii Rehd seeds and was first marketed as a medicament in German. With the wide application of SA in clinical practice, reports of adverse drug reactions and adverse events have gradually increased, including renal impairment. However, the pathogenic mechanisms of SA have not yet been fully elucidated. The toxic effects and underlying mechanisms of SA were explored in this study. Our data showed that SA significantly elevated the levels of blood urea nitrogen (BUN), ...
Source: Chemico-Biological Interactions - February 16, 2024 Category: Molecular Biology Authors: Haiyan Zhu Yenan Duan Yijing Yang Enqing Chen Hanxin Huang Xi Wang Jie Zhou Source Type: research
Development of substituted benzimidazoles as inhibitors of human aldehyde dehydrogenase 1A isoenzymes
Chem Biol Interact. 2024 Feb 14:110910. doi: 10.1016/j.cbi.2024.110910. Online ahead of print.ABSTRACTAldehyde dehydrogenase 1A (ALDH1A) isoforms may be a useful target for overcoming chemotherapy resistance in high-grade serous ovarian cancer (HGSOC) and other solid tumor cancers. However, as different cancers express different ALDH1A isoforms, isoform selective inhibitors may have a limited therapeutic scope. Furthermore, resistance to an ALDH1A isoform selective inhibitor could arise via induction of expression of other ALDH1A isoforms. As such, we have focused on the development of pan-ALDH1A inhibitors, rather than on...
Source: Chemico-Biological Interactions - February 16, 2024 Category: Molecular Biology Authors: Cyrus Takahashi Mikhail Chtcherbinine Brandt C Huddle Michael W Wilson Timothy Emmel Robert M Hohlman Stacy McGonigal Ronald J Buckanovich Scott D Larsen Thomas D Hurley Source Type: research
Sodium aescinate induces renal toxicity by promoting Nrf2/GPX4-mediated ferroptosis
Chem Biol Interact. 2024 Feb 15;391:110892. doi: 10.1016/j.cbi.2024.110892. Online ahead of print.ABSTRACTSodium aescinate (SA) is extracted from Aesculus wilsonii Rehd seeds and was first marketed as a medicament in German. With the wide application of SA in clinical practice, reports of adverse drug reactions and adverse events have gradually increased, including renal impairment. However, the pathogenic mechanisms of SA have not yet been fully elucidated. The toxic effects and underlying mechanisms of SA were explored in this study. Our data showed that SA significantly elevated the levels of blood urea nitrogen (BUN), ...
Source: Chemico-Biological Interactions - February 16, 2024 Category: Molecular Biology Authors: Haiyan Zhu Yenan Duan Yijing Yang Enqing Chen Hanxin Huang Xi Wang Jie Zhou Source Type: research
Development of substituted benzimidazoles as inhibitors of human aldehyde dehydrogenase 1A isoenzymes
Chem Biol Interact. 2024 Feb 14:110910. doi: 10.1016/j.cbi.2024.110910. Online ahead of print.ABSTRACTAldehyde dehydrogenase 1A (ALDH1A) isoforms may be a useful target for overcoming chemotherapy resistance in high-grade serous ovarian cancer (HGSOC) and other solid tumor cancers. However, as different cancers express different ALDH1A isoforms, isoform selective inhibitors may have a limited therapeutic scope. Furthermore, resistance to an ALDH1A isoform selective inhibitor could arise via induction of expression of other ALDH1A isoforms. As such, we have focused on the development of pan-ALDH1A inhibitors, rather than on...
Source: Chemico-Biological Interactions - February 16, 2024 Category: Molecular Biology Authors: Cyrus Takahashi Mikhail Chtcherbinine Brandt C Huddle Michael W Wilson Timothy Emmel Robert M Hohlman Stacy McGonigal Ronald J Buckanovich Scott D Larsen Thomas D Hurley Source Type: research
Trifluoperazine activates AMPK / mTOR / ULK1 signaling pathway to induce mitophagy in osteosarcoma cells
Chem Biol Interact. 2024 Feb 13:110904. doi: 10.1016/j.cbi.2024.110904. Online ahead of print.ABSTRACTOsteosarcoma is a prevalent kind of primary bone malignancy. Trifluoperazine, as an antipsychotic drug, has anti-tumor activity against a variety of cancers. Nevertheless, the impact of trifluoperazine on osteosarcoma is unclear. Our investigation aimed to explore the mechanism of trifluoperazine's effect on osteosarcoma. We found that trifluoperazine inhibited 143B and U2-OS osteosarcoma cell proliferation in a method based on the dose. Furthermore, it was shown that trifluoperazine induced the accumulation of reactive ox...
Source: Chemico-Biological Interactions - February 15, 2024 Category: Molecular Biology Authors: Wenhui Shen Xianhui Zeng Xiangchen Zeng Baoshan Hu Chong Ren Zhiming Lin Long Zhang Gang Rui Miersalijiang Yasen Xiaohui Chen Source Type: research
Trifluoperazine activates AMPK / mTOR / ULK1 signaling pathway to induce mitophagy in osteosarcoma cells
Chem Biol Interact. 2024 Feb 13:110904. doi: 10.1016/j.cbi.2024.110904. Online ahead of print.ABSTRACTOsteosarcoma is a prevalent kind of primary bone malignancy. Trifluoperazine, as an antipsychotic drug, has anti-tumor activity against a variety of cancers. Nevertheless, the impact of trifluoperazine on osteosarcoma is unclear. Our investigation aimed to explore the mechanism of trifluoperazine's effect on osteosarcoma. We found that trifluoperazine inhibited 143B and U2-OS osteosarcoma cell proliferation in a method based on the dose. Furthermore, it was shown that trifluoperazine induced the accumulation of reactive ox...
Source: Chemico-Biological Interactions - February 15, 2024 Category: Molecular Biology Authors: Wenhui Shen Xianhui Zeng Xiangchen Zeng Baoshan Hu Chong Ren Zhiming Lin Long Zhang Gang Rui Miersalijiang Yasen Xiaohui Chen Source Type: research
Pharmacokinetic interactions between tacrolimus and Wuzhi capsule in liver transplant recipients: Genetic polymorphisms affect the drug interaction
This study aims to evaluate the association between TAC dose-adjusted trough concentration (C/D) and specific genetic polymorphisms of CYP3A4/5, drug transporters and pregnane x receptor (PXR), and plasma levels of major WZC components, deoxyschisandrin and γ-schisandrin, in liver transplant patients receiving both TAC and WZC. Liquid chromatography-tandem-mass spectrometry was used to detect the plasma levels of deoxyschisandrin and γ-schisandrin, and nine polymorphisms related to metabolic enzymes, transporters and PXR were genotyped by sequencing. A linear mixed model was utilized to assess the impact of the interacti...
Source: Chemico-Biological Interactions - February 10, 2024 Category: Molecular Biology Authors: Siqi Huang Wei Song Shuangmiao Jiang Yuanchen Li Min Wang Na Yang Huaijun Zhu Source Type: research
Thyroid dysfunction caused by exposure to environmental endocrine disruptors and the underlying mechanism: A review
Chem Biol Interact. 2024 Feb 8;391:110909. doi: 10.1016/j.cbi.2024.110909. Online ahead of print.ABSTRACTThyroid disease has been rapidly increasing, but its causes remain unclear. At present, many studies have focused on the relationship between environmental endocrine disruptors (EEDs) and the pathogenesis of thyroid disease. Herein, we summarize such studies exploring the effects of exposure to common EEDs on thyrotoxicosis, finding that EEDs appear to contribute to the pathogenesis of thyroid-related diseases such as thyroid cancer, goiter, thyroiditis, hyperthyroidism, and hypothyroidism. To explore this causative eff...
Source: Chemico-Biological Interactions - February 10, 2024 Category: Molecular Biology Authors: Jie He Jie Xu Mucong Zheng Kai Pan Lilin Yang Lina Ma Chuyang Wang Jie Yu Source Type: research
