Selenium bioavailability modulates the sensitivity of thyroid cells to iodide excess
CONCLUSION: Our study suggests that Se bioavailability may improve the expression of antioxidant genes through the activation of Nrf2, interfere in PI3K/AKT signaling and NIS expression by redox modulation.PMID:38013145 | DOI:10.1016/j.cbi.2023.110810 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - November 28, 2023 Category: Molecular Biology Authors: Romina Oglio Carla Rodriguez Leonardo Salvarredi Luciano Rossich Marina Perona Alejandra Dagrosa Guillermo Juvenal Lisa Thomasz Source Type: research
Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease
Chem Biol Interact. 2023 Nov 26:110820. doi: 10.1016/j.cbi.2023.110820. Online ahead of print.ABSTRACTBaicalin, a potent anti-oxidative and anti-inflammatory flavonoid compound derived from Scutellaria baicalensis, has emerged as a neuroprotective agent. However, the mechanisms by which baicalin is neuroprotective in Parkinson's disease (PD) remain unclear. In this research, α-syn/MPP+ and MPTP were used to establish PD models in BV2 cells and C57BL/6 mice, respectively. The effect and mechanism of action of baicalin in PD were investigated by Western blotting, RT-qPCR, ELISA, immunohistochemistry (IHC) staining, immunofl...
Source: Chemico-Biological Interactions - November 28, 2023 Category: Molecular Biology Authors: Jiahua Huang Xinyue Zhang Xueping Yang Qingyun Yv Fanlong Ye Sheng Chen Ying Cui Linting Gu Min Zhu Wenwei Li Source Type: research
Selenium bioavailability modulates the sensitivity of thyroid cells to iodide excess
CONCLUSION: Our study suggests that Se bioavailability may improve the expression of antioxidant genes through the activation of Nrf2, interfere in PI3K/AKT signaling and NIS expression by redox modulation.PMID:38013145 | DOI:10.1016/j.cbi.2023.110810 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - November 28, 2023 Category: Molecular Biology Authors: Romina Oglio Carla Rodriguez Leonardo Salvarredi Luciano Rossich Marina Perona Alejandra Dagrosa Guillermo Juvenal Lisa Thomasz Source Type: research
Baicalin exerts neuroprotective actions by regulating the Nrf2-NLRP3 axis in toxin-induced models of Parkinson's disease
Chem Biol Interact. 2023 Nov 26:110820. doi: 10.1016/j.cbi.2023.110820. Online ahead of print.ABSTRACTBaicalin, a potent anti-oxidative and anti-inflammatory flavonoid compound derived from Scutellaria baicalensis, has emerged as a neuroprotective agent. However, the mechanisms by which baicalin is neuroprotective in Parkinson's disease (PD) remain unclear. In this research, α-syn/MPP+ and MPTP were used to establish PD models in BV2 cells and C57BL/6 mice, respectively. The effect and mechanism of action of baicalin in PD were investigated by Western blotting, RT-qPCR, ELISA, immunohistochemistry (IHC) staining, immunofl...
Source: Chemico-Biological Interactions - November 28, 2023 Category: Molecular Biology Authors: Jiahua Huang Xinyue Zhang Xueping Yang Qingyun Yv Fanlong Ye Sheng Chen Ying Cui Linting Gu Min Zhu Wenwei Li Source Type: research
Selenium bioavailability modulates the sensitivity of thyroid cells to iodide excess
CONCLUSION: Our study suggests that Se bioavailability may improve the expression of antioxidant genes through the activation of Nrf2, interfere in PI3K/AKT signaling and NIS expression by redox modulation.PMID:38013145 | DOI:10.1016/j.cbi.2023.110810 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - November 28, 2023 Category: Molecular Biology Authors: Romina Oglio Carla Rodriguez Leonardo Salvarredi Luciano Rossich Marina Perona Alejandra Dagrosa Guillermo Juvenal Lisa Thomasz Source Type: research
Retraction notice to "Agonism of GPR120 prevents ox-LDL-induced attachment of monocytes to endothelial cells" [Chem. Biol. Interact. 316 (2020) 108916]
Chem Biol Interact. 2023 Nov 26;387:110815. doi: 10.1016/j.cbi.2023.110815. Online ahead of print.NO ABSTRACTPMID:38011817 | DOI:10.1016/j.cbi.2023.110815 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - November 27, 2023 Category: Molecular Biology Authors: Tiechao Jiang Dongli Jiang Dong You Lirong Zhang Long Liu Qini Zhao Source Type: research
Exosomal derived miR-1246 from hydroquinone-transformed cells drives S phase accumulation arrest by targeting cyclin G2 in TK6 cells
CONCLUSION: HQ-transformed cells' exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.PMID:38006958 | DOI:10.1016/j.cbi.2023.110809 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - November 25, 2023 Category: Molecular Biology Authors: Yuting Chen Lin Chen Shiheng Zhu Hui Yang Zhongming Ye Huanhuan Wang Haipeng Wu Yao Wu Qian Sun Xiaoshan Liu Hairong Liang Huanwen Tang Source Type: research
Post-tuberculosis lung disease and inflammatory role players: can we characterise the myriad inflammatory pathways involved to gain a better understanding?
Chem Biol Interact. 2023 Nov 23:110817. doi: 10.1016/j.cbi.2023.110817. Online ahead of print.ABSTRACTTuberculosis (TB) remains a global health threat, and even after successful TB treatment, a subset of patients develops serious long-term lung impairments, recently termed post-tuberculosis lung disease (PTLD). Much remains to be discovered, as PTLD as a post-TB disease is a developing field, still in its infancy. The pathogenesis of PTLD is not fully elucidated but has been linked to elevated inflammatory pathways. The complexity of PTLD makes it challenging to pinpoint the specific inflammatory pathways involved in its p...
Source: Chemico-Biological Interactions - November 25, 2023 Category: Molecular Biology Authors: Lindiwe Malefane Gerald Maarman Source Type: research
PODO/TERT256 - A promising human immortalized podocyte cell line and its potential use for in vitro research at different oxygen levels
Chem Biol Interact. 2023 Nov 23:110813. doi: 10.1016/j.cbi.2023.110813. Online ahead of print.ABSTRACTPodocytes are of key interest for the prediction of nephrotoxicity as they are especially sensitive to toxic insults due to their central role in the glomerular filtration apparatus. However, currently, prediction of nephrotoxicity in humans remains insufficiently reliable, thus highlighting the need for advanced in vitro model systems using human cells with improved prediction capacity. Recent approaches for refining in vitro model systems focus on closely replicating physiological conditions as observed under the in vivo...
Source: Chemico-Biological Interactions - November 25, 2023 Category: Molecular Biology Authors: Nadja Schlichenmaier Alexander Zielinski Sascha Beneke Daniel R Dietrich Source Type: research
Exosomal derived miR-1246 from hydroquinone-transformed cells drives S phase accumulation arrest by targeting cyclin G2 in TK6 cells
CONCLUSION: HQ-transformed cells' exosomal miR-1246 targets CCNG2, regulating TK6 cell cycle arrest, highlighting its potential as a biomarker for HQ-induced malignant transformation.PMID:38006958 | DOI:10.1016/j.cbi.2023.110809 (Source: Chemico-Biological Interactions)
Source: Chemico-Biological Interactions - November 25, 2023 Category: Molecular Biology Authors: Yuting Chen Lin Chen Shiheng Zhu Hui Yang Zhongming Ye Huanhuan Wang Haipeng Wu Yao Wu Qian Sun Xiaoshan Liu Hairong Liang Huanwen Tang Source Type: research
Post-tuberculosis lung disease and inflammatory role players: can we characterise the myriad inflammatory pathways involved to gain a better understanding?
Chem Biol Interact. 2023 Nov 23:110817. doi: 10.1016/j.cbi.2023.110817. Online ahead of print.ABSTRACTTuberculosis (TB) remains a global health threat, and even after successful TB treatment, a subset of patients develops serious long-term lung impairments, recently termed post-tuberculosis lung disease (PTLD). Much remains to be discovered, as PTLD as a post-TB disease is a developing field, still in its infancy. The pathogenesis of PTLD is not fully elucidated but has been linked to elevated inflammatory pathways. The complexity of PTLD makes it challenging to pinpoint the specific inflammatory pathways involved in its p...
Source: Chemico-Biological Interactions - November 25, 2023 Category: Molecular Biology Authors: Lindiwe Malefane Gerald Maarman Source Type: research
PODO/TERT256 - A promising human immortalized podocyte cell line and its potential use for in vitro research at different oxygen levels
Chem Biol Interact. 2023 Nov 23:110813. doi: 10.1016/j.cbi.2023.110813. Online ahead of print.ABSTRACTPodocytes are of key interest for the prediction of nephrotoxicity as they are especially sensitive to toxic insults due to their central role in the glomerular filtration apparatus. However, currently, prediction of nephrotoxicity in humans remains insufficiently reliable, thus highlighting the need for advanced in vitro model systems using human cells with improved prediction capacity. Recent approaches for refining in vitro model systems focus on closely replicating physiological conditions as observed under the in vivo...
Source: Chemico-Biological Interactions - November 25, 2023 Category: Molecular Biology Authors: Nadja Schlichenmaier Alexander Zielinski Sascha Beneke Daniel R Dietrich Source Type: research
Ovatodiolide induces autophagy-mediated cell death through the p62-Keap1-Nrf2 signaling pathway in chronic myeloid leukemia cells
Chem Biol Interact. 2023 Nov 22:110819. doi: 10.1016/j.cbi.2023.110819. Online ahead of print.ABSTRACTOvatodiolide is a macrocyclic diterpenoid compound with various biological activities that displays considerable anticancer potential in different tumor models. However, the underlying mechanism for this antineoplastic activity remains unclear. The aim of the present study was to investigate the anticancer effect and possible molecular mechanism of ovatodiolide in human chronic myeloid leukemia (CML). Ovatodiolide suppressed cell colony formation and induced apoptosis in the K562 and KU812 cells. We also observed that ovat...
Source: Chemico-Biological Interactions - November 24, 2023 Category: Molecular Biology Authors: Qingqing Xia Jing Xie Jianguo Zhang Lingmin Zhang Yingying Zhou Bihong Zhu Yanfang Wu Zaixing Yang Jie Li Source Type: research
Phytic acid improves osteogenesis and inhibits the senescence of human bone marrow mesenchymal stem cells under high-glucose conditions via the ERK pathway
Chem Biol Interact. 2023 Nov 22:110818. doi: 10.1016/j.cbi.2023.110818. Online ahead of print.ABSTRACTHyperglycaemia causes impairment of osteogenic differentiation and accelerates stem cell senescence, resulting in weakened osteogenesis and disordered bone metabolism. Phytic acid (PA) is an antioxidant that is reportedly beneficial to bone homeostasis. The present study aims to clarify how PA affects the osteogenic capacity and cellular senescence of bone marrow mesenchymal stem cells (BMSCs) exposed to high-glucose environments, as well as the potential molecular mechanisms. Our results indicate that osteogenic different...
Source: Chemico-Biological Interactions - November 24, 2023 Category: Molecular Biology Authors: Dong-Yu Liu Jin Wu He-Yang Zhou Jia-Xin Lv Kun-Zhan Cai Chun-Bo Tang Source Type: research
Targeting PKM2 improves the gemcitabine sensitivity of intrahepatic cholangiocarcinoma cells via inhibiting β-catenin signaling pathway
Chem Biol Interact. 2023 Nov 22:110816. doi: 10.1016/j.cbi.2023.110816. Online ahead of print.ABSTRACTGemcitabine is considered the standard first-line chemotherapeutic agent for patients with intrahepatic cholangiocarcinoma (ICC). However, its therapeutic efficacy is hampered by the development of chemoresistance. Pyruvate kinase M2 (PKM2), a crucial mediator of the final step in glycolysis, has been implicated in the origination and advancement of diverse malignancies. Its expression is increased in many tumor types and this may correlate with increased drug sensitivity. However, the specific effect of PKM2 on the gemcit...
Source: Chemico-Biological Interactions - November 24, 2023 Category: Molecular Biology Authors: Wenna Yu Fuling Zeng Yang Xiao Liuyan Chen Hengdong Qu Jian Hong Chen Qu Cheng Guohua Source Type: research
