The effect of major postoperative complications on recurrence and long-term survival after cytoreductive surgery for ovarian cancer
CONCLUSIONS: Patients who experienced major surgical complications had reduced DFS, compared with patients without major morbidity. Extensive peritonectomy and surgical timing were predictive factors of postoperative morbidity.PMID:35568582 | DOI:10.1016/j.ygyno.2022.05.002 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 14, 2022 Category: Cancer & Oncology Authors: Martina Aida Angeles Alicia Hern ández Asunci ón Pérez-Benavente Bastien Cabarrou Emanuela Spagnolo Agnieszka Rychlik Amel Daboussi Federico Migliorelli Sarah B étrian Gw énaël Ferron Antonio Gil-Moreno Fr édéric Guyon Alejandra Martinez Source Type: research

Quality of life after extended pelvic exenterations
CONCLUSIONS: EPEs had post-treatment QoL and oncological outcome comparable to traditional PE. These procedures offer a potentially curative treatment option for patients with persistent or recurrent pelvic tumour invading into pelvic wall structures without further compromise of patients´ QoL.PMID:35568583 | DOI:10.1016/j.ygyno.2022.04.022 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 14, 2022 Category: Cancer & Oncology Authors: D Cibula Š Lednický E H öschlová J Sl áma M Wiesnerov á P Mit áš Z Mat ějovský M Schneiderov á P Dundr K N ěmejcová A Burgetov á L Z ámečník M Vo čka R Koci án F Fr ühauf L Dost álek D Fischerov á M Bor činová Source Type: research

The effect of major postoperative complications on recurrence and long-term survival after cytoreductive surgery for ovarian cancer
CONCLUSIONS: Patients who experienced major surgical complications had reduced DFS, compared with patients without major morbidity. Extensive peritonectomy and surgical timing were predictive factors of postoperative morbidity.PMID:35568582 | DOI:10.1016/j.ygyno.2022.05.002 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 14, 2022 Category: Cancer & Oncology Authors: Martina Aida Angeles Alicia Hern ández Asunci ón Pérez-Benavente Bastien Cabarrou Emanuela Spagnolo Agnieszka Rychlik Amel Daboussi Federico Migliorelli Sarah B étrian Gw énaël Ferron Antonio Gil-Moreno Fr édéric Guyon Alejandra Martinez Source Type: research

Quality of life after extended pelvic exenterations
CONCLUSIONS: EPEs had post-treatment QoL and oncological outcome comparable to traditional PE. These procedures offer a potentially curative treatment option for patients with persistent or recurrent pelvic tumour invading into pelvic wall structures without further compromise of patients´ QoL.PMID:35568583 | DOI:10.1016/j.ygyno.2022.04.022 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 14, 2022 Category: Cancer & Oncology Authors: D Cibula Š Lednický E H öschlová J Sl áma M Wiesnerov á P Mit áš Z Mat ějovský M Schneiderov á P Dundr K N ěmejcová A Burgetov á L Z ámečník M Vo čka R Koci án F Fr ühauf L Dost álek D Fischerov á M Bor činová Source Type: research

The effect of major postoperative complications on recurrence and long-term survival after cytoreductive surgery for ovarian cancer
CONCLUSIONS: Patients who experienced major surgical complications had reduced DFS, compared with patients without major morbidity. Extensive peritonectomy and surgical timing were predictive factors of postoperative morbidity.PMID:35568582 | DOI:10.1016/j.ygyno.2022.05.002 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 14, 2022 Category: Cancer & Oncology Authors: Martina Aida Angeles Alicia Hern ández Asunci ón Pérez-Benavente Bastien Cabarrou Emanuela Spagnolo Agnieszka Rychlik Amel Daboussi Federico Migliorelli Sarah B étrian Gw énaël Ferron Antonio Gil-Moreno Fr édéric Guyon Alejandra Martinez Source Type: research

Quality of life after extended pelvic exenterations
CONCLUSIONS: EPEs had post-treatment QoL and oncological outcome comparable to traditional PE. These procedures offer a potentially curative treatment option for patients with persistent or recurrent pelvic tumour invading into pelvic wall structures without further compromise of patients´ QoL.PMID:35568583 | DOI:10.1016/j.ygyno.2022.04.022 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 14, 2022 Category: Cancer & Oncology Authors: D Cibula Š Lednický E H öschlová J Sl áma M Wiesnerov á P Mit áš Z Mat ějovský M Schneiderov á P Dundr K N ěmejcová A Burgetov á L Z ámečník M Vo čka R Koci án F Fr ühauf L Dost álek D Fischerov á M Bor činová Source Type: research

Efficacy of niraparib by time of surgery and postoperative residual disease status: A post hoc analysis of patients in the PRIMA/ENGOT-OV26/GOG-3012 study
CONCLUSIONS: In this post hoc analysis, niraparib efficacy was similar across PDS and NACT/IDS subgroups. Patients who had NACT/IDS and VRD had the highest reduction in the risk of progression with niraparib maintenance.PMID:35550709 | DOI:10.1016/j.ygyno.2022.04.012 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 13, 2022 Category: Cancer & Oncology Authors: Roisin E O'Cearbhaill Jose-Alejandro P érez-Fidalgo Bradley J Monk Ignacio Tusquets Colleen McCormick Jose Fuentes Richard G Moore Christof Vulsteke Mark S Shahin Fr édéric Forget William H Bradley Sakari Hietanen David M O'Malley Anne D ørum Brian M Source Type: research

Declining use of inguinofemoral lymphadenectomy in the treatment of clinically negative, pathologic node positive vulvar cancer
CONCLUSIONS: Among cN-/pN+ vulvar cancer patients in the NCDB, the practice of performing IFL decreased over time as SLNB-alone became more common and the majority received radiation +/- chemotherapy. There was no difference in OS between SLNB-alone vs. IFL +/- SLNB. Patients treated with adjuvant chemoradiation had improved survival. Whether the favorable outcomes in the SLNB-alone cohort may be attributed to radiotherapy dose escalation or use of chemotherapy warrants further study.PMID:35550710 | DOI:10.1016/j.ygyno.2022.05.001 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 13, 2022 Category: Cancer & Oncology Authors: Meriem Mokhtech Sarah J Gao Megan Kassick Gulden Menderes Shari Damast Source Type: research

Role of tertiary cytoreductive surgery in recurrent epithelial ovarian cancer: Systematic review and meta-analysis
CONCLUSION: In this systematic review and meta-analysis of observational studies examining tertiary cytoreductive surgery for recurrent ovarian cancer, optimal tertiary cytoreductive surgery was associated with improved OS and DSS survival compared to suboptimal tertiary cytoreductive surgery.PMID:35550711 | DOI:10.1016/j.ygyno.2022.04.005 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 13, 2022 Category: Cancer & Oncology Authors: Francesco Guida Shayan Dioun Anna Fagotti Alexander Melamed Adriano Grossi Giovanni Scambia Jason D Wright Ana I Tergas Source Type: research

Efficacy of niraparib by time of surgery and postoperative residual disease status: A post hoc analysis of patients in the PRIMA/ENGOT-OV26/GOG-3012 study
CONCLUSIONS: In this post hoc analysis, niraparib efficacy was similar across PDS and NACT/IDS subgroups. Patients who had NACT/IDS and VRD had the highest reduction in the risk of progression with niraparib maintenance.PMID:35550709 | DOI:10.1016/j.ygyno.2022.04.012 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 13, 2022 Category: Cancer & Oncology Authors: Roisin E O'Cearbhaill Jose-Alejandro P érez-Fidalgo Bradley J Monk Ignacio Tusquets Colleen McCormick Jose Fuentes Richard G Moore Christof Vulsteke Mark S Shahin Fr édéric Forget William H Bradley Sakari Hietanen David M O'Malley Anne D ørum Brian M Source Type: research

Declining use of inguinofemoral lymphadenectomy in the treatment of clinically negative, pathologic node positive vulvar cancer
CONCLUSIONS: Among cN-/pN+ vulvar cancer patients in the NCDB, the practice of performing IFL decreased over time as SLNB-alone became more common and the majority received radiation +/- chemotherapy. There was no difference in OS between SLNB-alone vs. IFL +/- SLNB. Patients treated with adjuvant chemoradiation had improved survival. Whether the favorable outcomes in the SLNB-alone cohort may be attributed to radiotherapy dose escalation or use of chemotherapy warrants further study.PMID:35550710 | DOI:10.1016/j.ygyno.2022.05.001 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 13, 2022 Category: Cancer & Oncology Authors: Meriem Mokhtech Sarah J Gao Megan Kassick Gulden Menderes Shari Damast Source Type: research

Role of tertiary cytoreductive surgery in recurrent epithelial ovarian cancer: Systematic review and meta-analysis
CONCLUSION: In this systematic review and meta-analysis of observational studies examining tertiary cytoreductive surgery for recurrent ovarian cancer, optimal tertiary cytoreductive surgery was associated with improved OS and DSS survival compared to suboptimal tertiary cytoreductive surgery.PMID:35550711 | DOI:10.1016/j.ygyno.2022.04.005 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 13, 2022 Category: Cancer & Oncology Authors: Francesco Guida Shayan Dioun Anna Fagotti Alexander Melamed Adriano Grossi Giovanni Scambia Jason D Wright Ana I Tergas Source Type: research

Management and prognosis of cervical cancer patients treated with definitive radiation therapy who have partial metabolic response on post-therapy positron emission tomography
CONCLUSIONS: If PMR is identified on three-month FDG-PET following completion of radiation for cervical cancer, repeat FDG-PET and/or biopsy are indicated to detect persistence and assist in counseling. PMR predicts poor outcomes, particularly for those with positive cervical biopsies and lymphatic involvement.PMID:35537885 | DOI:10.1016/j.ygyno.2022.04.018 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 10, 2022 Category: Cancer & Oncology Authors: Tyler R Mckinnish Molly M Greenwade Ivy Wilkinson-Ryan Julie K Schwarz Matthew A Powell David G Mutch L Stewart Massad Perry W Grigsby Barry A Siegel Premal H Thaker Source Type: research

Management and prognosis of cervical cancer patients treated with definitive radiation therapy who have partial metabolic response on post-therapy positron emission tomography
CONCLUSIONS: If PMR is identified on three-month FDG-PET following completion of radiation for cervical cancer, repeat FDG-PET and/or biopsy are indicated to detect persistence and assist in counseling. PMR predicts poor outcomes, particularly for those with positive cervical biopsies and lymphatic involvement.PMID:35537885 | DOI:10.1016/j.ygyno.2022.04.018 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 10, 2022 Category: Cancer & Oncology Authors: Tyler R Mckinnish Molly M Greenwade Ivy Wilkinson-Ryan Julie K Schwarz Matthew A Powell David G Mutch L Stewart Massad Perry W Grigsby Barry A Siegel Premal H Thaker Source Type: research

Management and prognosis of cervical cancer patients treated with definitive radiation therapy who have partial metabolic response on post-therapy positron emission tomography
CONCLUSIONS: If PMR is identified on three-month FDG-PET following completion of radiation for cervical cancer, repeat FDG-PET and/or biopsy are indicated to detect persistence and assist in counseling. PMR predicts poor outcomes, particularly for those with positive cervical biopsies and lymphatic involvement.PMID:35537885 | DOI:10.1016/j.ygyno.2022.04.018 (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 10, 2022 Category: Cancer & Oncology Authors: Tyler R Mckinnish Molly M Greenwade Ivy Wilkinson-Ryan Julie K Schwarz Matthew A Powell David G Mutch L Stewart Massad Perry W Grigsby Barry A Siegel Premal H Thaker Source Type: research