Minimally invasive radical hysterectomy for early-stage cervical cancer: Volume-outcome relationship in the early experience period.
This study examined the association between hospital surgical volume for MIS-RH and perioperative outcomes for early-stage cervical cancer in the period of early adoption. METHODS: This population-based retrospective study queried the National Inpatient Sample from 2007 to 2011. Cervical cancer cases treated with MIS-RH were examined (n = 2202 from 163 hospitals). Annualized hospital surgical volume was defined as the average number of procedures performed per year in which at least one case was performed. Characteristics and outcomes related to MIS-RH use were assessed. The comparator cohort included RH by laparo...
Source: Gynecologic Oncology - May 27, 2020 Category: Cancer & Oncology Authors: Matsuo K, Matsuzaki S, Mandelbaum RS, Chang EJ, Klar M, Matsushima K, Grubbs BH, Roman LD, Wright JD Tags: Gynecol Oncol Source Type: research

Implications of extraperitoneal paraaortic lymphadenectomy to the left renal vein in locally advanced cervical cancer. A Spanish multicenter study.
CONCLUSIONS: In this study of patients with LACC undergoing surgical staging, paraaortic lymphadenectomy up to the left renal vein detected skip or isolated infrarenal metastasis in 9.6% of patients, with an acceptable surgical morbidity. PMID: 32467055 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 26, 2020 Category: Cancer & Oncology Authors: Díaz-Feijoo B, Franco S, Torné A, Benito V, Hernández A, Lago V, Rovira R, Acosta Ú, Agustí N, Gil-Moreno A, SEGO Spain-GOG Group Tags: Gynecol Oncol Source Type: research

Influence of uterine corpus invasion on prognosis in stage IA2-IIB cervical cancer: A multicenter retrospective cohort study.
Abstract OBJECTIVE: To determine the associations between the presence and depth of uterine corpus invasion and survival in patients with cervical cancer. METHODS: Clinical data of patients with stage IA2-IIB cervical cancer who underwent radical hysterectomy between 2004 and 2016 were retrospectively reviewed. Uterine corpus invasion was identified from a review of uterine pathology. Independent prognostic factors for 5-year disease-free survival (DFS) and overall survival (OS) were identified using multivariate forward stepwise Cox proportional hazards regression models. RESULTS: A total of 1414 patien...
Source: Gynecologic Oncology - May 26, 2020 Category: Cancer & Oncology Authors: He F, Li W, Liu P, Kang S, Sun L, Zhao H, Chen X, Yin L, Wang L, Chen J, Fan H, Li P, Yang H, Wang F, Chen C Tags: Gynecol Oncol Source Type: research

The prognostic role of horizontal and circumferential tumor extent in cervical cancer: Implications for the 2019 FIGO staging system.
Abstract OBJECTIVE: The FIGO 2019 update on cervical cancer staging removed horizontal tumor extent (HZTE) as a staging variable. Evidence is needed to substantiate this change. The prognostic significance of HZTE and a related variable, circumferential tumor extent (%CTE), is similarly unknown. We aimed to investigate the association of HZTE and %CTE with survival outcomes in cervical cancer patients. METHODS: We identified patients treated with primary surgery for stage I cervical cancer in a single institution during a 9-year period. HZTE and, when available, %CTE were obtained from pathology records. Case...
Source: Gynecologic Oncology - May 26, 2020 Category: Cancer & Oncology Authors: Zyla RE, Gien LT, Vicus D, Olkhov-Mitsel E, Mirkovic J, Nofech-Mozes S, Djordjevic B, Parra-Herran C Tags: Gynecol Oncol Source Type: research

Severe perioperative morbidity after robot-assisted versus conventional laparoscopy in gynecologic oncology: Results of the randomized ROBOGYN-1004 trial.
This study aimed to assess whether RL is superior to CL in terms of morbidity incidence. METHODS: ROBOGYN-1004 (ClinicalTrials.gov, NCT01247779) was a multicenter, phase III, superiority randomized trial that compared RL and CL in patients with gynecologic cancer requiring minimally invasive surgery. Patients were recruited between 2010 and 2015. The primary endpoint was incidence of severe perioperative morbidity (severe complications during or 6 months after surgery). RESULTS: Overall, 369 of 385 patients were included in the as-treated analysis: 176 and 193 underwent RL and CL, respectively. The median op...
Source: Gynecologic Oncology - May 25, 2020 Category: Cancer & Oncology Authors: Narducci F, Bogart E, Hebert T, Gauthier T, Collinet P, Classe JM, Lecuru F, Delest A, Motton S, Conri V, Ferrer C, Marchal F, Ferron G, Probst A, Thery J, Le Deley MC, Lefebvre D, Francon D, Leblanc E, Lambaudie E Tags: Gynecol Oncol Source Type: research

Should endometrial biopsy under direct hysteroscopic visualization using the grasp technique become the new gold standard for the preoperative evaluation of the patient with endometrial cancer?
CONCLUSIONS: Preoperative hysteroscopic guided "grasp" endometrial biopsy provides a more accurate diagnosis of EC histology type and tumor grade when in presence of endometrioid type tumor compared to blind endometrial biopsy obtained using the Novak curette. PMID: 32467056 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 25, 2020 Category: Cancer & Oncology Authors: Di Spiezio Sardo A, De Angelis MC, Della Corte L, Carugno J, Zizolfi B, Guadagno E, Gencarelli A, Cecchi E, Simoncini T, Bifulco G, Zullo F, Insabato L Tags: Gynecol Oncol Source Type: research

Locally advanced squamous cell carcinoma of the vulva: A challenging question for gynecologic oncologists.
Abstract Squamous cell carcinoma of the vulva is a rare female malignancy, with an incidence increasing with age. Unfortunately, one third of the patients are diagnosed with locally advanced disease, which constitutes a clinical challenge for the clinicians who treat these patients. The main challenges are represented by: 1. The primary site of the disease, which can be proximal to anatomical structures like the anal canal posteriorly, or the urethra and the bladder anteriorly, that in some circumstances cannot be spared without a bowel and/or urinary stoma; 2. The locoregional nodes that can be involved by the tu...
Source: Gynecologic Oncology - May 25, 2020 Category: Cancer & Oncology Authors: Gadducci A, Aletti GD Tags: Gynecol Oncol Source Type: research

The impact of near-infrared angiography and proctoscopy after rectosigmoid resection and anastomosis performed during surgeries for gynecologic malignancies.
Abstract OBJECTIVES: Reducing anastomotic leak rates after rectosigmoid resection and anastomosis is a priority in patients undergoing gynecologic oncology surgery. Therefore, we investigated the implications of performing near-infrared angiography (NIR) via proctoscopy to assess anastomotic perfusion at the time of rectosigmoid resection and anastomosis. METHODS: We identified all patients who underwent rectosigmoid resection and anastomosis for a gynecologic malignancy between January 1, 2013 and December 31, 2018. NIR proctoscopy was assessed via the PINPOINT Endoscopic Imaging System (Stryker). RESUL...
Source: Gynecologic Oncology - May 24, 2020 Category: Cancer & Oncology Authors: Moukarzel LA, Byrne ME, Leiva S, Wu M, Zhou QC, Iasonos A, Abu-Rustum NR, Sonoda Y, Gardner G, Leitao MM, Broach VA, Chi DS, Roche KL, Zivanovic O Tags: Gynecol Oncol Source Type: research

An international randomized phase III trial of pulse actinomycin-D versus multi-day methotrexate for the treatment of low risk gestational trophoblastic neoplasia; NRG/GOG 275.
CONCLUSIONS: The complete response rate for multi-day methotrexate was higher than actinomycin-D, but did not reach statistical significance. The multi-day MTX regimens were associated with significantly more mucositis and were significantly less convenient. PMID: 32460997 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 24, 2020 Category: Cancer & Oncology Authors: Schink JC, Filiaci V, Huang HQ, Tidy J, Winter M, Carter J, Anderson N, Moxley K, Yabuno A, Taylor SE, Kushnir C, Horowitz N, Miller DS Tags: Gynecol Oncol Source Type: research

Cervical cancer incidence and mortality rates in Kentucky.
Abstract OBJECTIVES: The goal of this study was to assess how the incidence and mortality of cervical cancer in Kentucky has changed from 1995 through 2017. Additionally, trends in incidence and mortality across different geographic areas and between different races were evaluated. METHODS: Age-adjusted annual incidence and mortality rates for cervical cancer were collected from the Kentucky Cancer Registry (KCR). A quadratic fit model was used to evaluate changes in the incidence and mortality over time and to compare differences in cervical cancer incidence and mortality by: 1) rural versus urban counties, ...
Source: Gynecologic Oncology - May 23, 2020 Category: Cancer & Oncology Authors: Silva SR, Gaskins JT, Nichols MR, Metzinger DS, Todd SL, Eldredge-Hindy HB Tags: Gynecol Oncol Source Type: research

Travel distance, hospital volume and their association with ovarian cancer short- and long-term outcomes.
Abstract OBJECTIVE: To examine patterns of patient travel among women with ovarian cancer and to explore the association between travel distance and short and long-term outcomes. METHODS: Women with stage II-IV epithelial ovarian cancer diagnosed from 2004 to 2016 who underwent primary surgery were identified in the National Cancer Database. Mixed-effect log-linear models and proportional hazards models were developed to evaluate the association between travel distance and short and long-term outcomes after propensity score weighting. A further analysis was performed to compare patients who traveled a short d...
Source: Gynecologic Oncology - May 23, 2020 Category: Cancer & Oncology Authors: Knisely A, Huang Y, Melamed A, Tergas AI, St Clair CM, Hou JY, Khoury-Collado F, Ananth CV, Neugut AI, Hershman DL, Wright JD Tags: Gynecol Oncol Source Type: research

Surgical training in gynecologic oncology: Past, present, future.
Abstract The purpose of this paper is to review the surgical care related to training in gynecologic oncology, from past, present and future perspectives. A marked decline in the incidence of cervical cancer as well as improvements in radiation therapy have led to a reduction in the numbers of radical hysterectomies and exenterations being performed. Utilization of neoadjuvant chemotherapy is reducing the extent of cytoreductive operations, including intestinal surgery. The incorporation of sentinel lymphatic mapping has reduced the number of pelvic, paraaortic and inguinal lymphadenectomies being performed. Coupl...
Source: Gynecologic Oncology - May 23, 2020 Category: Cancer & Oncology Authors: Hoffman MS, Chi DS, Clarke-Pearson DL, Cliby W, Creasman W, Underwood PB Tags: Gynecol Oncol Source Type: research

The development and evaluation of a nationwide training program for oncology health professionals in the provision of genetic testing for ovarian cancer patients.
CONCLUSIONS: Oncology healthcare professionals have demonstrated a willingness to be involved in the provision of genetic testing in a mainstreaming model. If oncology services are to hold responsibility for coordinating genetic testing, their readiness will require understanding of barriers not addressed by training alone to inform future intervention design. PMID: 32451123 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 22, 2020 Category: Cancer & Oncology Authors: Gleeson M, Kentwell M, Meiser B, Do J, Nevin S, Taylor N, Barlow-Stewart K, Kirk J, James P, Scott CL, Williams R, Gamet K, Burke J, Murphy M, Antill YC, Pearn A, Pachter N, Ebzery C, Poplawski N, Friedlander M, Tucker KM, Australian Genetic Testing Mains Tags: Gynecol Oncol Source Type: research

The immune suppressive factors CD155 and PD-L1 show contrasting expression patterns and immune correlates in ovarian and other cancers.
CONCLUSIONS: CD155 and PD-L1 exhibit contrasting expression patterns, TIL associations and prognostic significance, suggesting they represent non-redundant immunosuppressive mechanisms. The CD155/TIGIT pathway represents a compelling immunotherapeutic target for HGSC and for immunologically cold tumors in general. PMID: 32446718 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 20, 2020 Category: Cancer & Oncology Authors: Smazynski J, Hamilton PT, Thornton S, Milne K, Wouters MCA, Webb JR, Nelson BH Tags: Gynecol Oncol Source Type: research

Promoting health equity in the era of COVID-19.
PMID: 32446719 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 19, 2020 Category: Cancer & Oncology Authors: Farley JH, Hines J, Lee NK, Brooks SE, Nair N, Brown CL, Doll KM, Sullivan EJ, Chapman-Davis E Tags: Gynecol Oncol Source Type: research

Wait-time for hysterectomy and survival of women with early-stage cervical cancer: A clinical implication during the coronavirus pandemic.
This study examined the association between surgery wait-time of 8 weeks and oncologic outcome in women with early-stage cervical cancer. Methods: This is a single institution retrospective observational study at a tertiary referral medical center examining women who underwent primary hysterectomy or trachelectomy for clinical stage IA-IIA invasive cervical cancer between 2000 and 2017 (N = 217). Wait-time from the diagnosis of invasive cervical cancer via biopsy to definitive surgery was categorized as: short wait-time (
Source: Gynecologic Oncology - May 18, 2020 Category: Cancer & Oncology Authors: Matsuo K, Novatt H, Matsuzaki S, Hom MS, Castaneda AV, Licon E, Nusbaum DJ, Roman LD Tags: Gynecol Oncol Source Type: research

The use of indocyanine green fluorescence angiography to assess anastomotic perfusion following bowel resection in surgery for gynecologic malignancies - A report of 100 consecutive anastomoses.
CONCLUSIONS: ICG-FA enables objective and accurate intraoperative evaluation of anastomotic perfusion in surgeries for gynecologic malignancies. Its implementation and routine use were found to be safe and well-tolerated without side effects in our study cohort. ICG-FA can be used with other risk-assessment strategies to guide operative decision-making in Gynecologic Oncology. PMID: 32423604 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 15, 2020 Category: Cancer & Oncology Authors: Nguyen JMV, Hogen L, Laframboise S, Bouchard-Fortier G, Ferguson SE, Bernardini MQ, May T Tags: Gynecol Oncol Source Type: research

Fallopian tube abnormalities in uterine serous carcinoma.
CONCLUSIONS: In conclusion, the presence of Fallopian tube abnormalities was shown in a high percentage of patients with USC, representing either true precursor lesions or metastasized disease. PMID: 32409160 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 11, 2020 Category: Cancer & Oncology Authors: Steenbeek MP, Bulten J, Snijders MPLM, Lombaers M, Hendriks J, van den Brand M, Kraayenbrink AA, Massuger LFAG, Sweegers S, de Hullu JA, Pijnenborg JMA, Küsters-Vandevelde HVN, Reijnen C Tags: Gynecol Oncol Source Type: research

EMA vs EMACO in the treatment of gestational trophoblastic neoplasia.
Abstract OBJECTIVE: To compare experiences with EMA versus EMACO in the treatment of gestational trophoblastic neoplasia. METHODS: The medical records of women diagnosed with GTN at the New England Trophoblastic Disease Center from 1986 to 2019 were reviewed, and women receiving EMA or EMACO as their first multiagent regimen were eligible. Clinical characteristics, treatment, outcomes, and adverse events were compared between the two groups. RESULTS: We identified 44 and 39 patients who received EMA and EMACO, respectively. The complete remission rate was significantly higher in the EMA group (97.7%) tha...
Source: Gynecologic Oncology - May 11, 2020 Category: Cancer & Oncology Authors: Jareemit N, Horowitz NS, Goldstein DP, Berkowitz RS, Elias KM Tags: Gynecol Oncol Source Type: research

Knowledge of endometrial cancer risk factors in a general gynecologic population.
CONCLUSIONS: Regardless of education level, age or obesity status, the majority of women did not know the common risks of EC. Increased efforts towards educating women regarding obesity and other risk factors of EC are necessary in order to reduce the rising incidence of EC, a predominantly obesity-driven disease. Interventions must include general obstetrician-gynecologists and primary care providers. PMID: 32402632 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 10, 2020 Category: Cancer & Oncology Authors: Washington CR, Haggerty A, Ronner W, Neff PM, Ko EM Tags: Gynecol Oncol Source Type: research

Minimally invasive surgery for early-stage ovarian cancer: Association between hospital surgical volume and short-term perioperative outcomes.
Abstract OBJECTIVE: To examine trends and associated characteristics and outcomes of minimally invasive surgery (MIS) for women with early-stage ovarian cancer. METHODS: The National Inpatient Sample was queried to examine early-stage ovarian cancer treated with MIS from 2001 to 2011. Annualized hospital surgical volume was defined in the unweighted model as the average number of procedures performed per year in which at least one case was performed. Trends, characteristics, and outcomes related to MIS use were assessed in the weighted model. RESULTS: Among 73,707 oophorectomy cases, there were 4822 (6.5...
Source: Gynecologic Oncology - May 10, 2020 Category: Cancer & Oncology Authors: Matsuo K, Chang EJ, Matsuzaki S, Mandelbaum RS, Matsushima K, Grubbs BH, Klar M, Roman LD, Sood AK, Wright JD Tags: Gynecol Oncol Source Type: research

Clonal tumor mutations in homologous recombination genes predict favorable clinical outcome in ovarian cancer treated with platinum-based chemotherapy.
CONCLUSIONS: HRR clonal mutations, but not subclonal mutations, were associated with improved survival, chemotherapy response, and genome instability compared with HRR wild-type. PMID: 32402633 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 8, 2020 Category: Cancer & Oncology Authors: Luo S, Zhang Y, Yang Y, Zhu S, Liu W, Zhu J, Liang X, Jiang Z, Sun S, Hou X, Xiao Y, Li X Tags: Gynecol Oncol Source Type: research

Gestational trophoblastic neoplasia lethality among Brazilian women: A retrospective national cohort study.
CONCLUSION: The risk of mortality from low and high-risk GTN can be reduced by referral of these patients to a Reference Center or, if not possible, to involve clinicians in a Reference Center with consultation regarding management. PMID: 32402634 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 8, 2020 Category: Cancer & Oncology Authors: Freitas F, Braga A, Viggiano M, Velarde LGC, Maesta I, Uberti E, Madi JM, Yela D, Fernandes K, Silveira E, Leal E, Sun SY, Dos Santos Esteves APV, Filho JR, Junior JA, Elias KM, Horowitz NS, Berkowitz RS Tags: Gynecol Oncol Source Type: research

Survival outcomes in endometrial cancer patients having lymphadenectomy, sentinel node mapping followed by lymphadectomy and sentinel node mapping alone: Long-term results of a propensity-matched analysis.
PMID: 32389376 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 7, 2020 Category: Cancer & Oncology Authors: Bogani G, Casarin J, Maggiore ULR, Ditto A, Pinelli C, Dell'acqua A, Lopez S, Chiappa V, Brusadelli C, Guerrisi R, Ferrero S, Ghezzi F, Raspagliesi F Tags: Gynecol Oncol Source Type: research

Comparison of two Lynch screening strategies in endometrial cancer in a California health system.
Abstract OBJECTIVE: Compare detection of Lynch syndrome in endometrial cancer between regions of a health care system with different screening strategies. METHODS: A retrospective study of endometrial cancer (EC) cases from 2 regions of an integrated health care system (Kaiser Permanente Northern (KPNC) and Southern (KPSC) California). Within KPNC, immunohistochemistry tumor screening (IHC) was physician ordered and risk-based; within KPSC, IHC was universal and automated. Clinical risk factors associated with abnormal IHC and Lynch Syndrome (LS) were identified. RESULTS: During the study, there were 204...
Source: Gynecologic Oncology - May 6, 2020 Category: Cancer & Oncology Authors: Lentz SE, Salyer CV, Dontsi M, Armstrong MA, Hoodfar E, Alvarado MM, Avila M, Nguyen NT, Powell CB Tags: Gynecol Oncol Source Type: research

Oncologic outcomes and morbidity following heated intraperitoneal chemotherapy at cytoreductive surgery for primary epithelial ovarian cancer: A systematic review and meta-analysis.
CONCLUSION: One randomized trial suggests that HIPEC at time of interval cytoreductive surgery should be considered in patients with primary EOC. However, there is significant heterogeneity in literature with respect to an appropriate HIPEC regimen, short- and long-term outcomes. High-quality prospective randomized trials are urgently needed to clarify the role of HIPEC in the first-line treatment of primary EOC. PMID: 32387131 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 6, 2020 Category: Cancer & Oncology Authors: Bouchard-Fortier G, Cusimano MC, Fazelzad R, Sajewycz K, Lu L, Espin-Garcia O, May T, Bouchard-Fortier A, Ferguson SE Tags: Gynecol Oncol Source Type: research

Evaluating the impact of dose reductions and delays on progression-free survival in women with ovarian cancer treated with either three-weekly or dose-dense carboplatin and paclitaxel regimens in the national prospective OPAL cohort study.
Abstract OBJECTIVES: To determine the impact of chemotherapy dose reductions and dose delays on progression-free survival (PFS) in women with ovarian cancer receiving first line chemotherapy in a real world prospective cohort study. METHODS: Patients with newly diagnosed epithelial ovarian (or peritoneal, fallopian tube) cancer enrolled in a national Australian prospective study, OPAL, who commenced three-weekly carboplatin (AUC 5 or 6) and paclitaxel 175 mg/m2 (CP) or carboplatin (AUC 5 or 6) and dose-dense weekly paclitaxel 80 mg/m2 (DD-CP) were eligible. Primary endpoint was PFS. RESULTS: 63...
Source: Gynecologic Oncology - May 4, 2020 Category: Cancer & Oncology Authors: Sivakumaran T, Mileshkin L, Grant P, Na L, DeFazio A, Friedlander M, Obermair A, Webb PM, Au-Yeung G, OPAL Study Group Tags: Gynecol Oncol Source Type: research

Cervical cancer with ≤5 mm depth of invasion and > 7 mm horizontal spread - Is lymph node assessment only required in patients with LVSI?
Cervical cancer with ≤5 mm depth of invasion and>7 mm horizontal spread - Is lymph node assessment only required in patients with LVSI? Gynecol Oncol. 2020 May 04;: Authors: Wenzel HHB, Van Kol KGG, Nijman HW, Lemmens VEPP, Van der Aa MA, Ebisch RMF, Bekkers RLM Abstract OBJECTIVE: Cervical cancer with ≤5 mm depth of invasion and>7 mm horizontal spread is classified FIGO IA instead of FIGO IB in the revised staging system, as horizontal spread is no longer considered. We aimed to determine the incidence of lymph node metastasis (LNM) and, consequently, the necessity of pelvic lym...
Source: Gynecologic Oncology - May 4, 2020 Category: Cancer & Oncology Authors: Wenzel HHB, Van Kol KGG, Nijman HW, Lemmens VEPP, Van der Aa MA, Ebisch RMF, Bekkers RLM Tags: Gynecol Oncol Source Type: research

Survival of microsatellite-stable endometrioid endometrial cancer patients after minimally invasive surgery: An analysis of the Cancer Genome Atlas data.
CONCLUSIONS: Minimally invasive surgery is associated with more rapid recurrence in MSS endometrioid EC patients, thus indicating the necessity of microsatellite testing for guiding EC surgery. PMID: 32376044 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 4, 2020 Category: Cancer & Oncology Authors: Dai Y, Wang Z, Wang J Tags: Gynecol Oncol Source Type: research

Tumor specific methylome in Chinese high-grade serous ovarian cancer characterized by gene expression profile and tumor genotype.
CONCLUSIONS: Our individual and integrated analyses contribute details about the tissue-specific genetic and DNA methylation landscape of Chinese HGSOC. PMID: 32362568 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - May 1, 2020 Category: Cancer & Oncology Authors: Song F, Li L, Zhang B, Zhao Y, Zheng H, Yang M, Li X, Tian J, Huang C, Liu L, Wang Q, Zhang W, Chen K Tags: Gynecol Oncol Source Type: research

Cardiometabolic comorbidities and epithelial ovarian cancer risk among African-American women in the African-American Cancer Epidemiology Study (AACES).
CONCLUSION: Hypertension was associated with an increased EOC risk in this patient population, whereas an inverse association was observed for diabetes and hyperlipidemia. The decreased risk of EOC identified with use of anti-hypertensive, anti-diabetes or lipid-lowering medications could have implications for risk reduction strategies. PMID: 32362566 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 30, 2020 Category: Cancer & Oncology Authors: Staples JN, Peres LC, Camacho F, Alberg AJ, Bandera EV, Barnholtz-Sloan J, Bondy ML, Cote ML, Funkhouser E, Moorman PG, Peters ES, Schwartz AG, Terry PD, Schildkraut JM Tags: Gynecol Oncol Source Type: research

How to triage HPV positive cases: Results of four million females.
CONCLUSION: This study involves the largest series in the world summarizing a real-world experience with primary HPV DNA screening and triage with a single visit. The results show the feasibility and applicability of such screening method in developing countries with acceptable colposcopy referral rates. Among triage tests, only pap-smear seems to be effective without a need for extended genotyping. PMID: 32362567 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 30, 2020 Category: Cancer & Oncology Authors: Gultekin M, Dundar S, Keskinkilic B, Turkyilmaz M, Ozgul N, Yuce K, Kara F Tags: Gynecol Oncol Source Type: research

Development of a screening tool to improve the referral of patients with breast and gynecological cancer to outpatient palliative care.
Abstract OBJECTIVE: New strategies that allow timely referral to outpatient palliative care (PC) for cancer patients are sought. The authors developed a 16-item checklist tool with 3 categories of care priorities based on patients' physical functionality. To evaluate the potential clinical impact of the use of these criteria in patients with advanced breast and gynecological cancer (ABGC) seen at oncology clinics. METHODS: The study was divided into 2 phases. In Phase I, research nurse prospectively assessed the referral criteria among patients with ABGC who had not yet been referred to PC. The oncologists' (...
Source: Gynecologic Oncology - April 30, 2020 Category: Cancer & Oncology Authors: Paiva CE, Paiva BSR, Menezes D, Zanini LE, Ciorlia JB, Miwa MU, Hui D Tags: Gynecol Oncol Source Type: research

Performance of lymphadenectomy for apparent early stage malignant ovarian germ cell tumors in the era of platinum-based chemotherapy.
CONCLUSIONS: While LN metastasis is common in apparent early stage MOGCTs, the performance of LND was not associated with a survival benefit. PMID: 32359845 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 28, 2020 Category: Cancer & Oncology Authors: Nasioudis D, Ko EM, Haggerty AF, Cory L, Giuntoli RL, Burger RA, Morgan MA, Latif NA Tags: Gynecol Oncol Source Type: research

Comparison of urologic complications between laparoscopic radical hysterectomy and abdominal radical hysterectomy: A nationwide study from the National Health Insurance.
This study aimed to assess the risks of intraoperative and postoperative urologic complications between laparoscopic radical hysterectomy (LRH) and abdominal radical hysterectomy (ARH). METHODS: Using the database of the National Health Insurance Service (NHIS) and Health Insurance Review & Assessment (HIRA), we identified all Korean women who underwent radical hysterectomy between 2006 and 2018. Intraoperative and postoperative urologic complications were compared between the ARH and LRH groups. RESULTS: A total of 11,399 patients were identified to ARH and 8435 patients to LRH. Urologic complications occurr...
Source: Gynecologic Oncology - April 27, 2020 Category: Cancer & Oncology Authors: Hwang JH, Kim BW, Jeong H, Kim H Tags: Gynecol Oncol Source Type: research

Effect of bilateral salpingo-oophorectomy on the overall survival of premenopausal patients with stage I low-grade endometrial stromal sarcoma; a National Cancer Database analysis.
Abstract OBJECTIVES: Investigate the prevalence of bilateral salpingo-oophorectomy (BSO) for women ≤50 years with early stage low-grade endometrial stromal sarcoma (LGESS) and its impact on overall survival (OS). METHODS: Women ≤50 years, diagnosed with stage I LGESS and managed with hysterectomy between 2004 and 2015 were identified from the National Cancer Database. Patient demographics were recorded and compared with the chi-square test. OS for patients diagnosed between 2004 and 2014 with at least one month of follow-up was assessed using Kaplan-Meier curves, and compared with the log-rank...
Source: Gynecologic Oncology - April 27, 2020 Category: Cancer & Oncology Authors: Nasioudis D, Mastroyannis SA, Latif NA, Ko EM, Haggerty AF, Kim SH, Morgan MA, Giuntoli RL Tags: Gynecol Oncol Source Type: research

Endometrial cancer presentation is associated with social determinants of health in a public healthcare system: A population-based cohort study.
Abstract OBJECTIVE: Delay in diagnosis of endometrial cancer may be associated with disease progression and impact management and outcomes. Social and cultural barriers influence recognition of symptoms and self-advocacy in seeking care. Associations between social determinants of health (SDH) and disease presentation have been shown in some settings. Our objective was to investigate these in Ontario's universal access system. METHODS: Endometrial cancer patients in Ontario diagnosed 2009-2017 were identified, and clinical, social and demographic information extracted from administrative databases using ICES ...
Source: Gynecologic Oncology - April 27, 2020 Category: Cancer & Oncology Authors: Helpman L, Pond GR, Elit L, Anderson LN, Seow H Tags: Gynecol Oncol Source Type: research

Possibly carcinogenic HPV subtypes are a cause of HSIL and negative clinical HPV tests - A European prospective single center study.
CONCLUSIONS: Possibly carcinogenic HPV subtypes not included in the clinical HPV tests may account for the small gap of missed HSIL in clinical HPV screening. True HPV negative HSIL are exceedingly rare. Expanding HPV testing to include more possibly carcinogenic HPV subtypes may further reduce cervical cancer. PMID: 32354471 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 27, 2020 Category: Cancer & Oncology Authors: Reich O, Regauer S, Kashofer K Tags: Gynecol Oncol Source Type: research

The added value of sentinel node mapping in endometrial cancer.
CONCLUSION: Addition of SLN to LND was ultimately associated with improved clinical outcomes compared to LND alone in patients with endometrial cancer undergoing surgical staging, suggesting that the data provided by the analysis of the SLN added relevant clinical information, and improved the decision on adjuvant therapy. PMID: 32349874 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 27, 2020 Category: Cancer & Oncology Authors: Kogan L, Matanes E, Wissing M, Mitric C, How J, Amajoud Z, Abitbol J, Yasmeen A, López-Ozuna V, Eisenberg N, Lau S, Salvador S, Gotlieb WH Tags: Gynecol Oncol Source Type: research

Prolonged interruption of chemotherapy in patients undergoing delayed debulking surgery for advanced high grade serous ovarian cancer is associated with a worse prognosis.
CONCLUSION: Our study recommends that interruption to chemotherapy to allow patients to undergo ICS should be ≤10 weeks; otherwise, OS is significantly impacted. Patients with pre-existing medical comorbidities should receive additional support pre- and post-operatively to keep the chemotherapy interruption to a minimum. PMID: 32345546 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 25, 2020 Category: Cancer & Oncology Authors: Searle G, Pounds R, Phillips A, Kehoe S, Balega J, Singh K, Yap J Tags: Gynecol Oncol Source Type: research

The effectiveness of online interventions for patients with gynecological cancer: An integrative review.
CONCLUSIONS: Online interventions have been increasingly used as clinically promising interventions to promote health outcomes among patients with gynecological cancer. Studies with more rigorous designs and sufficient sample sizes are needed to elucidate the effectiveness of such online interventions. Healthcare workers can incorporate existing or new online interventions into their routine care to improve health outcomes for patients with gynecological cancer. PMID: 32340692 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 24, 2020 Category: Cancer & Oncology Authors: Lin H, Ye M, Chan SW, Zhu J, He H Tags: Gynecol Oncol Source Type: research

Quality assurance in surgical trials: An improvement is needed.
PMID: 32334828 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 22, 2020 Category: Cancer & Oncology Authors: Lecuru F, Osdoit M, Balaya V, Faron EL, Feron JG, Laki F, Fourchotte V, Reyal F, Asselain B Tags: Gynecol Oncol Source Type: research

Molecular subtypes of clear cell carcinoma of the endometrium: Opportunities for prognostic and predictive stratification.
CONCLUSION: CCC is a heterogeneous disease encompassing all four molecular subtypes and a wide range of clinical outcomes. Outcomes of patients with POLEmut, MMRd and p53abn CCC are not distinguishable from those of other patients with these respective subtypes of EC; p53wt CCC, however, differ from endometrioid p53wt EC in clinical, pathological, molecular features and outcomes. Thus, p53wt CCC of endometrium appear to be a distinct clinicopathological entity within the larger group of p53wt ECs. PMID: 32331700 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 21, 2020 Category: Cancer & Oncology Authors: Kim SR, Cloutier BT, Leung S, Cochrane D, Britton H, Pina A, Storness-Bliss C, Farnell D, Huang L, Shum K, Lum A, Senz J, Lee CH, Gilks CB, Hoang L, McAlpine JN Tags: Gynecol Oncol Source Type: research

Common medications and survival in women with ovarian cancer: A systematic review and meta-analysis.
Abstract OBJECTIVES: Ovarian cancer is usually diagnosed at an advanced stage when five-year relative survival is
Source: Gynecologic Oncology - April 18, 2020 Category: Cancer & Oncology Authors: Majidi A, Na R, Dixon-Suen S, Jordan SJ, Webb PM Tags: Gynecol Oncol Source Type: research

Transcriptome profiling of gastric-type endocervical adenocarcinomas identifies key signaling pathways for tumor progression.
CONCLUSIONS: This transcriptomic study identified a signature that supports the classification of endocervical carcinomas as three distinct entities: usual-, intestinal- and gastric-type. It also points out to disruption of tight junctions as a potential mechanism of metastatic dissemination of these rare tumors. PMID: 32317172 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 18, 2020 Category: Cancer & Oncology Authors: Vasseur D, Lopez J, Croce S, Tondeur G, Bonin L, Descotes F, Golfier F, Devouassoux-Shisheboran M Tags: Gynecol Oncol Source Type: research

The impact of depressive symptoms on health value in patients with gynecologic cancer: A comparison with physical symptoms and performance status.
In this study, the effects of depressive symptoms on health utility value (HUV) in gynecologic cancer patients are evaluated. In addition, the effects were compared with those of performance status and physical symptoms. METHODS: Patient-reported outcome data from 274 gynecologic cancer patients were prospectively collected. HUV was measured using the 3-level version of the EuroQoL 5-dimension descriptive system (EQ-5D-3L) and the EuroQoL visual analog scale (EQ-VAS). The Patient Health Questionnaire-9 (PHQ-9) was used to measure the severity of depressive symptoms. The impact of depressive symptoms on HUV was analyze...
Source: Gynecologic Oncology - April 16, 2020 Category: Cancer & Oncology Authors: Yu YL, Yeo H, Kang S Tags: Gynecol Oncol Source Type: research

Gynecologic cancer incidence and mortality among American Indian/Alaska Native women in the Pacific Northwest, 1996-2016.
CONCLUSION: Our analysis of gynecologic cancers among AI/AN in the PNW found significant disparities relative to NHW women in cervical cancer incidence and mortality. These disparities persist despite advances in prevention strategies. PMID: 32305303 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 15, 2020 Category: Cancer & Oncology Authors: Bruegl AS, Joshi S, Batman S, Weisenberger M, Munro E, Becker T Tags: Gynecol Oncol Source Type: research

Corrigendum to "An update on the use of immunohistochemistry and molecular pathology in the diagnosis of pre-invasive and malignant lesions in gynecological oncology" [Gynecol. Oncol. 150 (2018) 378-386].
Corrigendum to "An update on the use of immunohistochemistry and molecular pathology in the diagnosis of pre-invasive and malignant lesions in gynecological oncology" [Gynecol. Oncol. 150 (2018) 378-386]. Gynecol Oncol. 2020 Apr 13;: Authors: Kalampokas E, Payne F, Nomikos A, Gurumurthy M PMID: 32299629 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 13, 2020 Category: Cancer & Oncology Authors: Kalampokas E, Payne F, Nomikos A, Gurumurthy M Tags: Gynecol Oncol Source Type: research

A novel laparoscopic technique for retro-aortic and retro-caval lymphadenectomy.
PMID: 32291117 [PubMed - as supplied by publisher] (Source: Gynecologic Oncology)
Source: Gynecologic Oncology - April 11, 2020 Category: Cancer & Oncology Authors: Liu C, Duan K, Liang X, Lv X, Liu D, Yang Y, Guan X Tags: Gynecol Oncol Source Type: research

Incidence of vulvar high-grade precancerous lesions and cancer in Denmark before and after introduction of HPV vaccination.
Abstract OBJECTIVE: To assess the incidence of vulvar high-grade precancerous lesions and cancer in Denmark during 1997-2018. METHODS: We identified incident vulvar cancer cases in the Danish Cancer Registry and incident cases of vulvar precancerous lesions in the Danish Pathology Register. We calculated age-standardized incidence rates of vulvar squamous cell carcinoma (VSCC), non-SCC and precancerous lesions, and age-specific incidence rates of VSCC and precancerous lesions. Incidence trends were evaluated using linear Poisson regression to estimate the average annual percentage change (AAPC). For vulvar pr...
Source: Gynecologic Oncology - April 7, 2020 Category: Cancer & Oncology Authors: Rasmussen CL, Thomsen LT, Aalborg GL, Kjaer SK Tags: Gynecol Oncol Source Type: research